JP2002544234A5 - - Google Patents
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- Publication number
- JP2002544234A5 JP2002544234A5 JP2000617907A JP2000617907A JP2002544234A5 JP 2002544234 A5 JP2002544234 A5 JP 2002544234A5 JP 2000617907 A JP2000617907 A JP 2000617907A JP 2000617907 A JP2000617907 A JP 2000617907A JP 2002544234 A5 JP2002544234 A5 JP 2002544234A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- bone marrow
- brain
- spinal cord
- marrow stromal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004556 brain Anatomy 0.000 description 14
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 12
- 239000003814 drug Substances 0.000 description 11
- 210000000278 spinal cord Anatomy 0.000 description 9
- 210000002569 neuron Anatomy 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 210000001185 bone marrow Anatomy 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000002054 transplantation Methods 0.000 description 5
- 210000003169 central nervous system Anatomy 0.000 description 4
- 210000004958 brain cell Anatomy 0.000 description 3
- 208000029028 brain injury Diseases 0.000 description 3
- 208000020431 spinal cord injury Diseases 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000001361 intraarterial administration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 230000000626 neurodegenerative effect Effects 0.000 description 2
- 210000004738 parenchymal cell Anatomy 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13434499P | 1999-05-14 | 1999-05-14 | |
| US60/134,344 | 1999-05-14 | ||
| PCT/US2000/012875 WO2000069448A1 (en) | 1999-05-14 | 2000-05-11 | Bone marrow transplantation for treatment of stroke |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002544234A JP2002544234A (ja) | 2002-12-24 |
| JP2002544234A5 true JP2002544234A5 (https=) | 2010-09-16 |
Family
ID=22462927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617907A Pending JP2002544234A (ja) | 1999-05-14 | 2000-05-11 | 発作の処置のための骨髄移植 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090162327A1 (https=) |
| EP (1) | EP1183035B1 (https=) |
| JP (1) | JP2002544234A (https=) |
| AU (1) | AU780994B2 (https=) |
| CA (1) | CA2373808C (https=) |
| DK (1) | DK1183035T3 (https=) |
| ES (1) | ES2531592T3 (https=) |
| PT (1) | PT1183035E (https=) |
| WO (1) | WO2000069448A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US20050169896A1 (en) * | 1999-05-14 | 2005-08-04 | Henry Ford Health System | Bone marrow transplantation for treatment of stroke |
| US8017112B2 (en) | 1999-05-14 | 2011-09-13 | Henry Ford Health System | Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases |
| BR0013388A (pt) * | 1999-08-18 | 2002-08-27 | Gen Hospital Corp | Processos, composições e kits para promover a recuperação de lesões do sistema nervoso central |
| US6749850B1 (en) | 1999-08-18 | 2004-06-15 | The General Hospital Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
| US20010038836A1 (en) * | 2000-04-04 | 2001-11-08 | Matthew During | Application of myeloid-origin cells to the nervous system |
| CA2413910A1 (en) | 2000-06-26 | 2002-12-27 | Renomedix Institute Inc. | Cell fractions containing cells capable of differentating into neural cells |
| ES2180433B1 (es) * | 2001-05-28 | 2004-05-16 | Universidad Miguel Hernandez De Elche. | Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales. |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US20040259254A1 (en) * | 2001-10-30 | 2004-12-23 | Osamu Honmou | Method for inducing differentiation mesodermal stem cells, es cells or immortalized cells into nervous system cells |
| WO2003056899A2 (en) | 2002-01-04 | 2003-07-17 | Henry Ford Health System | Nitric oxide donors for treatment of disease and injury |
| EP1471970A4 (en) | 2002-01-14 | 2006-08-02 | Univ Illinois | NOVEL MULTIPOTENT STEM CELLS OF MAMMALIAN ORIGIN, METHODS OF PREPARATION AND METHODS OF ADMINISTRATION OF SAID CELLS |
| US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US20060210544A1 (en) | 2003-06-27 | 2006-09-21 | Renomedix Institute, Inc. | Internally administered therapeutic agents for cranial nerve diseases comprising mesenchymal cells as an active ingredient |
| JPWO2005007176A1 (ja) * | 2003-06-27 | 2006-08-31 | 株式会社レノメディクス研究所 | 間葉系細胞を有効成分とする体内投与用脳神経疾患治療薬 |
| RU2283121C2 (ru) * | 2004-11-29 | 2006-09-10 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Способ лечения инсульта |
| US20080107632A1 (en) * | 2006-09-06 | 2008-05-08 | Henrich Cheng | Fibrin glue composition for repairing nerve damage and methods thereof |
| NZ582616A (en) | 2007-06-15 | 2012-07-27 | Garnet Biotherapeutics Inc | Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro |
| JP5276816B2 (ja) * | 2007-09-10 | 2013-08-28 | 肇 井上 | 神経機能改善剤 |
| JP2011513318A (ja) * | 2008-02-28 | 2011-04-28 | ヘンリ フオルド ヘルス システム | 中枢神経系損傷の治療を強化するために間質細胞を使用する組成物及び方法 |
| JP6156889B2 (ja) | 2013-02-06 | 2017-07-05 | Ｎｃメディカルリサーチ株式会社 | 神経変性の治療のための不均質な骨髄細胞の亜集団を調製する方法 |
| CN105814196A (zh) * | 2013-10-14 | 2016-07-27 | 哈达斯特医疗研究服务和开发有限公司 | 终末分化的神经元谱系的获得方法及其用途 |
| JPWO2015174087A1 (ja) * | 2014-05-16 | 2017-04-20 | 公益財団法人先端医療振興財団 | 脳梗塞の予防及び／又は治療の為の医薬 |
| RU2612981C1 (ru) * | 2015-12-21 | 2017-03-14 | Алексей Сергеевич Бывальцев | Способ лечения ишемического инсульта |
| US11464804B1 (en) | 2017-11-15 | 2022-10-11 | Enrico Stazzone | Intrathecal multifactorial infusion of heterogeneous autologous cell therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666828A (en) * | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) * | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) * | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5612211A (en) * | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
| US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| JPH08509215A (ja) * | 1993-04-13 | 1996-10-01 | アメリカ合衆国 | 移植治療のための神経由来胎児セルラインの使用 |
| US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| WO1999056759A1 (en) * | 1998-05-07 | 1999-11-11 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| GB9904281D0 (en) * | 1999-02-24 | 1999-04-21 | Reneuron Ltd | Transplantation |
-
2000
- 2000-05-11 JP JP2000617907A patent/JP2002544234A/ja active Pending
- 2000-05-11 ES ES00935910.0T patent/ES2531592T3/es not_active Expired - Lifetime
- 2000-05-11 WO PCT/US2000/012875 patent/WO2000069448A1/en not_active Ceased
- 2000-05-11 AU AU51300/00A patent/AU780994B2/en not_active Ceased
- 2000-05-11 CA CA2373808A patent/CA2373808C/en not_active Expired - Fee Related
- 2000-05-11 PT PT00935910T patent/PT1183035E/pt unknown
- 2000-05-11 EP EP00935910.0A patent/EP1183035B1/en not_active Expired - Lifetime
- 2000-05-11 DK DK00935910T patent/DK1183035T3/en active
-
2008
- 2008-10-10 US US12/249,687 patent/US20090162327A1/en not_active Abandoned
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