JP2002544234A5 - - Google Patents
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- Publication number
- JP2002544234A5 JP2002544234A5 JP2000617907A JP2000617907A JP2002544234A5 JP 2002544234 A5 JP2002544234 A5 JP 2002544234A5 JP 2000617907 A JP2000617907 A JP 2000617907A JP 2000617907 A JP2000617907 A JP 2000617907A JP 2002544234 A5 JP2002544234 A5 JP 2002544234A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- bone marrow
- brain
- spinal cord
- marrow stromal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004556 brain Anatomy 0.000 description 14
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 12
- 239000003814 drug Substances 0.000 description 11
- 210000000278 spinal cord Anatomy 0.000 description 9
- 210000002569 neuron Anatomy 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 210000001185 bone marrow Anatomy 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000002054 transplantation Methods 0.000 description 5
- 210000003169 central nervous system Anatomy 0.000 description 4
- 210000004958 brain cell Anatomy 0.000 description 3
- 208000029028 brain injury Diseases 0.000 description 3
- 208000020431 spinal cord injury Diseases 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000001361 intraarterial administration Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 230000000626 neurodegenerative effect Effects 0.000 description 2
- 210000004738 parenchymal cell Anatomy 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13434499P | 1999-05-14 | 1999-05-14 | |
| US60/134,344 | 1999-05-14 | ||
| PCT/US2000/012875 WO2000069448A1 (en) | 1999-05-14 | 2000-05-11 | Bone marrow transplantation for treatment of stroke |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002544234A JP2002544234A (ja) | 2002-12-24 |
| JP2002544234A5 true JP2002544234A5 (https=) | 2010-09-16 |
Family
ID=22462927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617907A Pending JP2002544234A (ja) | 1999-05-14 | 2000-05-11 | 発作の処置のための骨髄移植 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090162327A1 (https=) |
| EP (1) | EP1183035B1 (https=) |
| JP (1) | JP2002544234A (https=) |
| AU (1) | AU780994B2 (https=) |
| CA (1) | CA2373808C (https=) |
| DK (1) | DK1183035T3 (https=) |
| ES (1) | ES2531592T3 (https=) |
| PT (1) | PT1183035E (https=) |
| WO (1) | WO2000069448A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US20050169896A1 (en) * | 1999-05-14 | 2005-08-04 | Henry Ford Health System | Bone marrow transplantation for treatment of stroke |
| US8017112B2 (en) | 1999-05-14 | 2011-09-13 | Henry Ford Health System | Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases |
| IL148175A0 (en) * | 1999-08-18 | 2002-09-12 | Gen Hospital Corp | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
| US6749850B1 (en) | 1999-08-18 | 2004-06-15 | The General Hospital Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
| WO2001075094A1 (en) * | 2000-04-04 | 2001-10-11 | Thomas Jefferson University | Application of myeloid-origin cells to the nervous system |
| EP1302534A4 (en) | 2000-06-26 | 2004-06-16 | Renomedix Inst Inc | CELL FRACTION WITH CELLS WHICH ARE ABLE TO DIFFERENTIATE IN NERVOUS CELLS |
| ES2180433B1 (es) * | 2001-05-28 | 2004-05-16 | Universidad Miguel Hernandez De Elche. | Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales. |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| WO2003038075A1 (en) * | 2001-10-30 | 2003-05-08 | Renomedix Institute Inc. | Method of inducing differentiation of mesodermal stem cells, es cells or immortalized cells into nervous system cells |
| EP1469852A4 (en) * | 2002-01-04 | 2009-12-02 | Ford Henry Health System | NITROGEN DONORS FOR THE TREATMENT OF DISEASE AND INJURY |
| AU2003202988A1 (en) | 2002-01-14 | 2003-07-30 | The Board Of Trustees Of The University Of Illinois | Use of modified pyrimidine compounds to promote stem cell migration and proliferation |
| US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| WO2005007176A1 (ja) * | 2003-06-27 | 2005-01-27 | Renomedix Institute Inc. | 間葉系細胞を有効成分とする体内投与用脳神経疾患治療薬 |
| US20060210544A1 (en) | 2003-06-27 | 2006-09-21 | Renomedix Institute, Inc. | Internally administered therapeutic agents for cranial nerve diseases comprising mesenchymal cells as an active ingredient |
| RU2283121C2 (ru) * | 2004-11-29 | 2006-09-10 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Способ лечения инсульта |
| US20080107632A1 (en) * | 2006-09-06 | 2008-05-08 | Henrich Cheng | Fibrin glue composition for repairing nerve damage and methods thereof |
| EP2171043B1 (en) | 2007-06-15 | 2015-03-18 | Garnet BioTherapeutics, Inc | Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro |
| JP5276816B2 (ja) * | 2007-09-10 | 2013-08-28 | 肇 井上 | 神経機能改善剤 |
| WO2009108632A1 (en) * | 2008-02-28 | 2009-09-03 | Henry Ford Health System | Compositions and methods for using stromal cells to enhance treatment of central nervous system injuries |
| EP2953473B1 (en) | 2013-02-06 | 2018-11-28 | Nc Medical Research Inc. | Method of producing a heterogeneous subpopulation of bone marrow cells suitable for the treatement of neurodegeneration cased by ischemic stroke |
| CA2926575C (en) * | 2013-10-14 | 2023-01-31 | Hadasit Medical Research Services & Development Limited | Method of obtaining terminally differentiated neuronal lineages and uses thereof |
| WO2015174087A1 (ja) * | 2014-05-16 | 2015-11-19 | 公益財団法人先端医療振興財団 | 脳梗塞の予防及び／又は治療の為の医薬 |
| RU2612981C1 (ru) * | 2015-12-21 | 2017-03-14 | Алексей Сергеевич Бывальцев | Способ лечения ишемического инсульта |
| US11464804B1 (en) | 2017-11-15 | 2022-10-11 | Enrico Stazzone | Intrathecal multifactorial infusion of heterogeneous autologous cell therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666828A (en) * | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) * | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) * | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5612211A (en) * | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
| US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| PT696205E (pt) * | 1993-04-13 | 2002-07-31 | Us Gov Health & Human Serv | Utilizacao de linhas celulares fetais nauro-derivadas para terapia de transplantacao |
| US6653134B2 (en) * | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| AU3888699A (en) * | 1998-05-07 | 1999-11-23 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| GB9904281D0 (en) * | 1999-02-24 | 1999-04-21 | Reneuron Ltd | Transplantation |
-
2000
- 2000-05-11 ES ES00935910.0T patent/ES2531592T3/es not_active Expired - Lifetime
- 2000-05-11 EP EP00935910.0A patent/EP1183035B1/en not_active Expired - Lifetime
- 2000-05-11 DK DK00935910T patent/DK1183035T3/en active
- 2000-05-11 AU AU51300/00A patent/AU780994B2/en not_active Ceased
- 2000-05-11 CA CA2373808A patent/CA2373808C/en not_active Expired - Fee Related
- 2000-05-11 JP JP2000617907A patent/JP2002544234A/ja active Pending
- 2000-05-11 WO PCT/US2000/012875 patent/WO2000069448A1/en not_active Ceased
- 2000-05-11 PT PT00935910T patent/PT1183035E/pt unknown
-
2008
- 2008-10-10 US US12/249,687 patent/US20090162327A1/en not_active Abandoned
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