CA2373808C - Bone marrow transplantation for treatment of central nervous system damage - Google Patents

Bone marrow transplantation for treatment of central nervous system damage Download PDF

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Publication number
CA2373808C
CA2373808C CA2373808A CA2373808A CA2373808C CA 2373808 C CA2373808 C CA 2373808C CA 2373808 A CA2373808 A CA 2373808A CA 2373808 A CA2373808 A CA 2373808A CA 2373808 C CA2373808 C CA 2373808C
Authority
CA
Canada
Prior art keywords
cells
bone marrow
brain
spinal cord
transplantation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2373808A
Other languages
English (en)
French (fr)
Other versions
CA2373808A1 (en
Inventor
Yi Li
Michael Chopp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henry Ford Health System
Original Assignee
Henry Ford Health System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henry Ford Health System filed Critical Henry Ford Health System
Publication of CA2373808A1 publication Critical patent/CA2373808A1/en
Application granted granted Critical
Publication of CA2373808C publication Critical patent/CA2373808C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CA2373808A 1999-05-14 2000-05-11 Bone marrow transplantation for treatment of central nervous system damage Expired - Fee Related CA2373808C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13434499P 1999-05-14 1999-05-14
US60/134,344 1999-05-14
PCT/US2000/012875 WO2000069448A1 (en) 1999-05-14 2000-05-11 Bone marrow transplantation for treatment of stroke

Publications (2)

Publication Number Publication Date
CA2373808A1 CA2373808A1 (en) 2000-11-23
CA2373808C true CA2373808C (en) 2011-04-19

Family

ID=22462927

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2373808A Expired - Fee Related CA2373808C (en) 1999-05-14 2000-05-11 Bone marrow transplantation for treatment of central nervous system damage

Country Status (9)

Country Link
US (1) US20090162327A1 (https=)
EP (1) EP1183035B1 (https=)
JP (1) JP2002544234A (https=)
AU (1) AU780994B2 (https=)
CA (1) CA2373808C (https=)
DK (1) DK1183035T3 (https=)
ES (1) ES2531592T3 (https=)
PT (1) PT1183035E (https=)
WO (1) WO2000069448A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US20050169896A1 (en) * 1999-05-14 2005-08-04 Henry Ford Health System Bone marrow transplantation for treatment of stroke
US8017112B2 (en) 1999-05-14 2011-09-13 Henry Ford Health System Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases
BR0013388A (pt) * 1999-08-18 2002-08-27 Gen Hospital Corp Processos, composições e kits para promover a recuperação de lesões do sistema nervoso central
US6749850B1 (en) 1999-08-18 2004-06-15 The General Hospital Corporation Methods, compositions and kits for promoting recovery from damage to the central nervous system
US20010038836A1 (en) * 2000-04-04 2001-11-08 Matthew During Application of myeloid-origin cells to the nervous system
CA2413910A1 (en) 2000-06-26 2002-12-27 Renomedix Institute Inc. Cell fractions containing cells capable of differentating into neural cells
ES2180433B1 (es) * 2001-05-28 2004-05-16 Universidad Miguel Hernandez De Elche. Empleo de celulas madre hematopoyeticas en la generacion de celulas madre neurales.
US9969980B2 (en) 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
US20040259254A1 (en) * 2001-10-30 2004-12-23 Osamu Honmou Method for inducing differentiation mesodermal stem cells, es cells or immortalized cells into nervous system cells
WO2003056899A2 (en) 2002-01-04 2003-07-17 Henry Ford Health System Nitric oxide donors for treatment of disease and injury
EP1471970A4 (en) 2002-01-14 2006-08-02 Univ Illinois NOVEL MULTIPOTENT STEM CELLS OF MAMMALIAN ORIGIN, METHODS OF PREPARATION AND METHODS OF ADMINISTRATION OF SAID CELLS
US9969977B2 (en) 2002-09-20 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
US20060210544A1 (en) 2003-06-27 2006-09-21 Renomedix Institute, Inc. Internally administered therapeutic agents for cranial nerve diseases comprising mesenchymal cells as an active ingredient
JPWO2005007176A1 (ja) * 2003-06-27 2006-08-31 株式会社レノメディクス研究所 間葉系細胞を有効成分とする体内投与用脳神経疾患治療薬
RU2283121C2 (ru) * 2004-11-29 2006-09-10 Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН Способ лечения инсульта
US20080107632A1 (en) * 2006-09-06 2008-05-08 Henrich Cheng Fibrin glue composition for repairing nerve damage and methods thereof
NZ582616A (en) 2007-06-15 2012-07-27 Garnet Biotherapeutics Inc Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro
JP5276816B2 (ja) * 2007-09-10 2013-08-28 肇 井上 神経機能改善剤
JP2011513318A (ja) * 2008-02-28 2011-04-28 ヘンリ フオルド ヘルス システム 中枢神経系損傷の治療を強化するために間質細胞を使用する組成物及び方法
JP6156889B2 (ja) 2013-02-06 2017-07-05 Ｎｃメディカルリサーチ株式会社 神経変性の治療のための不均質な骨髄細胞の亜集団を調製する方法
CN105814196A (zh) * 2013-10-14 2016-07-27 哈达斯特医疗研究服务和开发有限公司 终末分化的神经元谱系的获得方法及其用途
JPWO2015174087A1 (ja) * 2014-05-16 2017-04-20 公益財団法人先端医療振興財団 脳梗塞の予防及び／又は治療の為の医薬
RU2612981C1 (ru) * 2015-12-21 2017-03-14 Алексей Сергеевич Бывальцев Способ лечения ишемического инсульта
US11464804B1 (en) 2017-11-15 2022-10-11 Enrico Stazzone Intrathecal multifactorial infusion of heterogeneous autologous cell therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666828A (en) * 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) * 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) * 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) * 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5612211A (en) * 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US5851832A (en) * 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
JPH08509215A (ja) * 1993-04-13 1996-10-01 アメリカ合衆国 移植治療のための神経由来胎児セルラインの使用
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
WO1999056759A1 (en) * 1998-05-07 1999-11-11 University Of South Florida Bone marrow cells as a source of neurons for brain and spinal cord repair
GB9904281D0 (en) * 1999-02-24 1999-04-21 Reneuron Ltd Transplantation

Also Published As

Publication number Publication date
DK1183035T3 (en) 2015-03-09
PT1183035E (pt) 2015-03-04
JP2002544234A (ja) 2002-12-24
US20090162327A1 (en) 2009-06-25
AU5130000A (en) 2000-12-05
CA2373808A1 (en) 2000-11-23
ES2531592T3 (es) 2015-03-17
EP1183035A4 (en) 2003-05-07
EP1183035B1 (en) 2014-12-03
AU780994B2 (en) 2005-04-28
EP1183035A1 (en) 2002-03-06
WO2000069448A1 (en) 2000-11-23

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Effective date: 20170511