JP2002541114A5 - - Google Patents

Info

Publication number

JP2002541114A5

JP2002541114A5 JP2000609081A JP2000609081A JP2002541114A5 JP 2002541114 A5 JP2002541114 A5 JP 2002541114A5 JP 2000609081 A JP2000609081 A JP 2000609081A JP 2000609081 A JP2000609081 A JP 2000609081A JP 2002541114 A5 JP2002541114 A5 JP 2002541114A5

Authority

JP

Japan

Prior art keywords

dna

prostate cancer

mycobacterium

medicament

growth

Prior art date

2000-03-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 206010060862 Prostate cancer Diseases 0.000 description 47
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 47
• 239000003814 drug Substances 0.000 description 40
• 241000186359 Mycobacterium Species 0.000 description 27
• 210000004027 cell Anatomy 0.000 description 24
• 230000012010 growth Effects 0.000 description 19
• 239000000203 mixture Substances 0.000 description 19
• 241000187481 Mycobacterium phlei Species 0.000 description 14
• 239000003937 drug carrier Substances 0.000 description 14
• 102000004127 Cytokines Human genes 0.000 description 11
• 108090000695 Cytokines Proteins 0.000 description 11
• 241001465754 Metazoa Species 0.000 description 10
• 239000003153 chemical reaction reagent Substances 0.000 description 10
• 230000015572 biosynthetic process Effects 0.000 description 9
• 210000002421 cell wall Anatomy 0.000 description 9
• 230000002401 inhibitory effect Effects 0.000 description 9
• 229940055036 mycobacterium phlei Drugs 0.000 description 9
• 238000003786 synthesis reaction Methods 0.000 description 9
• 230000006698 induction Effects 0.000 description 6
• 230000001939 inductive effect Effects 0.000 description 6
• 210000002307 prostate Anatomy 0.000 description 6
• MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
• 239000003098 androgen Substances 0.000 description 4
• 239000005556 hormone Substances 0.000 description 4
• 229940088597 hormone Drugs 0.000 description 4
• 239000007788 liquid Substances 0.000 description 4
• 230000000717 retained effect Effects 0.000 description 4
• 239000007787 solid Substances 0.000 description 4
• 230000001629 suppression Effects 0.000 description 4
• 230000006907 apoptotic process Effects 0.000 description 3
• 210000002865 immune cell Anatomy 0.000 description 3
• 241000186367 Mycobacterium avium Species 0.000 description 2
• 241000186366 Mycobacterium bovis Species 0.000 description 2
• 241000186365 Mycobacterium fortuitum Species 0.000 description 2
• 241000186363 Mycobacterium kansasii Species 0.000 description 2
• 241000187480 Mycobacterium smegmatis Species 0.000 description 2
• 241000187644 Mycobacterium vaccae Species 0.000 description 2
• 230000002280 anti-androgenic effect Effects 0.000 description 2
• 239000000051 antiandrogen Substances 0.000 description 2
• 239000002246 antineoplastic agent Substances 0.000 description 2
• 230000001580 bacterial effect Effects 0.000 description 2
• 229940127089 cytotoxic agent Drugs 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 210000000987 immune system Anatomy 0.000 description 2
• 229940124452 immunizing agent Drugs 0.000 description 2
• 230000006882 induction of apoptosis Effects 0.000 description 2
• 239000008194 pharmaceutical composition Substances 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2
• 150000003431 steroids Chemical class 0.000 description 2
• 229960003604 testosterone Drugs 0.000 description 2
• 201000008827 tuberculosis Diseases 0.000 description 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• 206010053759 Growth retardation Diseases 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 206010028980 Neoplasm Diseases 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 201000011510 cancer Diseases 0.000 description 1
• 230000009702 cancer cell proliferation Effects 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 238000000034 method Methods 0.000 description 1