JP2002540077A5 - - Google Patents
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- Publication number
- JP2002540077A5 JP2002540077A5 JP2000606266A JP2000606266A JP2002540077A5 JP 2002540077 A5 JP2002540077 A5 JP 2002540077A5 JP 2000606266 A JP2000606266 A JP 2000606266A JP 2000606266 A JP2000606266 A JP 2000606266A JP 2002540077 A5 JP2002540077 A5 JP 2002540077A5
- Authority
- JP
- Japan
- Prior art keywords
- chitosan
- polycationic carbohydrate
- polycationic
- composition according
- carbohydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000014633 carbohydrates Nutrition 0.000 description 27
- 150000001720 carbohydrates Chemical class 0.000 description 26
- 238000000034 method Methods 0.000 description 22
- 239000000203 mixture Substances 0.000 description 22
- 229920001661 Chitosan Polymers 0.000 description 17
- 125000002091 cationic group Chemical group 0.000 description 11
- 230000003308 immunostimulating effect Effects 0.000 description 11
- 239000013543 active substance Substances 0.000 description 9
- 239000002245 particle Substances 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 229920002101 Chitin Polymers 0.000 description 7
- 229960001438 immunostimulant agent Drugs 0.000 description 6
- 239000003022 immunostimulating agent Substances 0.000 description 6
- 244000052769 pathogen Species 0.000 description 5
- 230000001717 pathogenic effect Effects 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 239000003223 protective agent Substances 0.000 description 4
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- 229930195712 glutamate Natural products 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 229920001983 poloxamer Polymers 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 101710168515 Cell surface glycoprotein Proteins 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 101710099182 S-layer protein Proteins 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- -1 cationic carbohydrate Chemical class 0.000 description 1
- 229960002798 cetrimide Drugs 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000002077 nanosphere Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229920001432 poly(L-lactide) Polymers 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9906694.6A GB9906694D0 (en) | 1999-03-24 | 1999-03-24 | Vaccine composition |
| GBGB9906696.1A GB9906696D0 (en) | 1999-03-24 | 1999-03-24 | Vaccine composition |
| GB9906694.6 | 1999-03-24 | ||
| GB9906696.1 | 1999-03-24 | ||
| PCT/GB2000/001118 WO2000056362A2 (en) | 1999-03-24 | 2000-03-23 | Polycationic carbohydrates as immunostimulants in vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011204971A Division JP2012031186A (ja) | 1999-03-24 | 2011-09-20 | ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002540077A JP2002540077A (ja) | 2002-11-26 |
| JP2002540077A5 true JP2002540077A5 (https=) | 2007-05-24 |
| JP5124066B2 JP5124066B2 (ja) | 2013-01-23 |
Family
ID=26315329
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000606265A Withdrawn JP2002540076A (ja) | 1999-03-24 | 2000-03-23 | ワクチン組成物 |
| JP2000606266A Expired - Fee Related JP5124066B2 (ja) | 1999-03-24 | 2000-03-23 | ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用 |
| JP2011204971A Pending JP2012031186A (ja) | 1999-03-24 | 2011-09-20 | ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000606265A Withdrawn JP2002540076A (ja) | 1999-03-24 | 2000-03-23 | ワクチン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011204971A Pending JP2012031186A (ja) | 1999-03-24 | 2011-09-20 | ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080057083A1 (https=) |
| EP (2) | EP1163001A2 (https=) |
| JP (3) | JP2002540076A (https=) |
| AT (1) | ATE403436T1 (https=) |
| AU (2) | AU755502C (https=) |
| CA (2) | CA2366908A1 (https=) |
| DE (1) | DE60039754D1 (https=) |
| DK (1) | DK1163002T3 (https=) |
| ES (1) | ES2311451T3 (https=) |
| NZ (1) | NZ514323A (https=) |
| WO (2) | WO2000056361A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2272447T3 (es) * | 2000-03-22 | 2007-05-01 | The Secretary Of State For Defence | Composicion farmaceutica para aplicar en superficies mucosas. |
| US7767197B2 (en) | 2000-06-22 | 2010-08-03 | Endo Pharmaceuticals Colorado LLC | Delivery vehicle composition and methods for delivering antigens and other drugs |
| BR0111948A (pt) | 2000-06-26 | 2004-08-24 | Rxkinetix Inc | Composição para entrega de fator de crescimento hematopoiético |
| EP2241309A3 (en) * | 2001-07-10 | 2012-12-26 | Corixa Corporation | Methods for encapsulation of proteins and adjuants in microspheres |
| CN1543338B (zh) | 2001-08-16 | 2010-06-16 | Cmp医疗有限公司 | 壳多糖微粒及其医疗用途 |
| CA2383259A1 (en) | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| WO2003028696A2 (en) * | 2001-10-03 | 2003-04-10 | Celator Technologies Inc. | Compositions for delivery of drug combinations |
| US7850990B2 (en) | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| GB0300885D0 (en) * | 2003-01-15 | 2003-02-12 | Secr Defence | Pharmaceutical composition |
| ATE426412T1 (de) * | 2003-01-30 | 2009-04-15 | Novartis Vaccines & Diagnostic | Adjuvante influenza-vakzine |
| JP2006516609A (ja) * | 2003-01-30 | 2006-07-06 | カイロン ソチエタ ア レスポンサビリタ リミタータ | 粘膜髄膜炎菌性ワクチン |
| EP1631264B8 (en) | 2003-06-02 | 2017-05-24 | GlaxoSmithKline Biologicals SA | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
| JP4669665B2 (ja) * | 2004-04-12 | 2011-04-13 | 正彦 阿部 | 細胞毒性のないポリカチオン修飾リポソームおよびその製造方法 |
| GB0519871D0 (en) | 2005-09-30 | 2005-11-09 | Secr Defence | Immunogenic agents |
| WO2007100699A2 (en) * | 2006-02-24 | 2007-09-07 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| WO2008041703A1 (en) * | 2006-10-02 | 2008-04-10 | Osaka University | Adjuvant for influenza vaccine and influenza vaccine |
| JP5297009B2 (ja) * | 2007-07-24 | 2013-09-25 | 大日精化工業株式会社 | 免疫アジュバント水溶液 |
| MY148321A (en) * | 2007-10-02 | 2013-03-29 | Malaysian Palm Oil Board Mpob | Vitamin e supplementation to tetanus toxoid |
| GB0721937D0 (en) | 2007-11-08 | 2007-12-19 | Secr Defence | Rodenticide |
| CA2733147A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | Microparticles for use in immunogenic compositions |
| GB0900455D0 (en) | 2009-01-13 | 2009-02-11 | Secr Defence | Vaccine |
| ES2728653T3 (es) | 2011-05-18 | 2019-10-28 | Matrivax Inc | Composiciones vacunales con una matriz proteica que incluye policationes |
| WO2012164480A1 (en) * | 2011-05-30 | 2012-12-06 | National Institute Of Immunology | A vaccine composition capable of inducing memory antibody response from single point immunization |
| CN107200788B (zh) * | 2017-05-11 | 2020-04-14 | 暨南大学 | 一种季鏻化壳聚糖及其作为疫苗免疫佐剂的应用 |
| CN107899021A (zh) * | 2017-11-06 | 2018-04-13 | 扬州大学 | 一种表面修饰s‑层蛋白的壳聚糖微球、制备及应用 |
| KR102384808B1 (ko) * | 2018-12-20 | 2022-04-08 | 주식회사 스킨메드 | 키토산으로 코팅된 나노 캡슐 및 이의 용도 |
| EP3960203A1 (en) | 2020-08-25 | 2022-03-02 | Université de Liège | Complexes for the delivery of proteinaceous agents |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3740421A (en) * | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
| GB1290141A (https=) * | 1968-05-31 | 1972-09-20 | ||
| FR2306684A1 (fr) * | 1975-04-11 | 1976-11-05 | Crinex Lab | Nouvelle composition a action immunostimulante |
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US5811128A (en) * | 1986-10-24 | 1998-09-22 | Southern Research Institute | Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor |
| EP0283085B1 (en) * | 1987-03-17 | 1992-11-11 | Akzo N.V. | Adjuvant mixture |
| EP0382271B1 (en) * | 1989-02-04 | 1994-12-21 | Akzo Nobel N.V. | Tocols as adjuvant in vaccine |
| US5562910A (en) * | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
| US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
| US5709860A (en) * | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| US5292513A (en) * | 1992-05-18 | 1994-03-08 | Anthony G. Gristina | Method for nonspecific cellular immune stimulation |
| EP0688205A1 (en) * | 1993-03-11 | 1995-12-27 | Secretech, Inc. | Polymeric mucoadhesives in the delivery of immunogens at mucosal surfaces |
| US6913767B1 (en) * | 1993-10-25 | 2005-07-05 | Genentech, Inc. | Compositions for microencapsulation of antigens for use as vaccines |
| US5643605A (en) * | 1993-10-25 | 1997-07-01 | Genentech, Inc. | Methods and compositions for microencapsulation of adjuvants |
| US5902565A (en) * | 1993-12-24 | 1999-05-11 | Csl Limited | Spray dried vaccine preparation comprising aluminium adsorbed immunogens |
| GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
| EP0805678B1 (en) * | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
| CA2215203C (en) * | 1995-03-13 | 2008-12-09 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Vaccines for plague |
| US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| GB9525083D0 (en) * | 1995-12-07 | 1996-02-07 | Danbiosyst Uk | Vaccine compositions |
| DE19603649A1 (de) * | 1996-02-01 | 1997-08-07 | Werner Lubitz | Rekombinante Expression von S-Layer-Proteinen |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| GB9810126D0 (https=) * | 1998-05-13 | 1998-07-08 | Glaxo Group Ltd | |
| EP1126826B3 (en) * | 1998-11-02 | 2019-05-15 | Alkermes Pharma Ireland Limited | Multiparticulate modified release composition of methylphenidate |
| US20030171258A1 (en) * | 1999-03-24 | 2003-09-11 | Alpar Hazire Oya | Particle based vaccine composition |
| US20020103165A1 (en) * | 2000-02-29 | 2002-08-01 | Alliance Pharmaceutical Corp., | Engineered spray-dried lipid-based microparticles for cellular targeting |
| ES2272447T3 (es) * | 2000-03-22 | 2007-05-01 | The Secretary Of State For Defence | Composicion farmaceutica para aplicar en superficies mucosas. |
| GB0300885D0 (en) * | 2003-01-15 | 2003-02-12 | Secr Defence | Pharmaceutical composition |
-
2000
- 2000-03-23 NZ NZ514323A patent/NZ514323A/xx unknown
- 2000-03-23 CA CA002366908A patent/CA2366908A1/en not_active Abandoned
- 2000-03-23 WO PCT/GB2000/001104 patent/WO2000056361A2/en not_active Ceased
- 2000-03-23 AU AU34435/00A patent/AU755502C/en not_active Ceased
- 2000-03-23 DK DK00912788T patent/DK1163002T3/da active
- 2000-03-23 JP JP2000606265A patent/JP2002540076A/ja not_active Withdrawn
- 2000-03-23 AT AT00912788T patent/ATE403436T1/de active
- 2000-03-23 AU AU34424/00A patent/AU762078B2/en not_active Ceased
- 2000-03-23 JP JP2000606266A patent/JP5124066B2/ja not_active Expired - Fee Related
- 2000-03-23 DE DE60039754T patent/DE60039754D1/de not_active Expired - Lifetime
- 2000-03-23 EP EP00912777A patent/EP1163001A2/en not_active Withdrawn
- 2000-03-23 EP EP00912788A patent/EP1163002B1/en not_active Expired - Lifetime
- 2000-03-23 WO PCT/GB2000/001118 patent/WO2000056362A2/en not_active Ceased
- 2000-03-23 CA CA2366216A patent/CA2366216C/en not_active Expired - Fee Related
- 2000-03-23 ES ES00912788T patent/ES2311451T3/es not_active Expired - Lifetime
-
2007
- 2007-10-29 US US11/926,468 patent/US20080057083A1/en not_active Abandoned
-
2011
- 2011-09-20 JP JP2011204971A patent/JP2012031186A/ja active Pending
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