JP2002532535A5 - - Google Patents
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- Publication number
- JP2002532535A5 JP2002532535A5 JP2000589161A JP2000589161A JP2002532535A5 JP 2002532535 A5 JP2002532535 A5 JP 2002532535A5 JP 2000589161 A JP2000589161 A JP 2000589161A JP 2000589161 A JP2000589161 A JP 2000589161A JP 2002532535 A5 JP2002532535 A5 JP 2002532535A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- delivery system
- vesicle
- drug delivery
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012377 drug delivery Methods 0.000 description 20
- 239000004094 surface-active agent Substances 0.000 description 20
- 238000000034 method Methods 0.000 description 18
- 229940079593 drug Drugs 0.000 description 16
- 239000003814 drug Substances 0.000 description 16
- 239000006185 dispersion Substances 0.000 description 9
- 239000003960 organic solvent Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- AYUNIORJHRXIBJ-TXHRRWQRSA-N tanespimycin Chemical compound N1C(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC2=C(NCC=C)C(=O)C=C1C2=O AYUNIORJHRXIBJ-TXHRRWQRSA-N 0.000 description 3
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical group CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- -1 carboxamide triazole Chemical class 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000012929 tonicity agent Substances 0.000 description 2
- 102100029469 WD repeat and HMG-box DNA-binding protein 1 Human genes 0.000 description 1
- 101710097421 WD repeat and HMG-box DNA-binding protein 1 Proteins 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940043274 prophylactic drug Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11342398P | 1998-12-22 | 1998-12-22 | |
| US60/113,423 | 1998-12-22 | ||
| PCT/US1999/030631 WO2000037050A1 (en) | 1998-12-22 | 1999-12-22 | Water-insoluble drug delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002532535A JP2002532535A (ja) | 2002-10-02 |
| JP2002532535A5 true JP2002532535A5 (https=) | 2007-02-01 |
Family
ID=22349322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000589161A Pending JP2002532535A (ja) | 1998-12-22 | 1999-12-22 | 水不溶性薬剤送達システム |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1140017B9 (https=) |
| JP (1) | JP2002532535A (https=) |
| AT (1) | ATE289801T1 (https=) |
| AU (1) | AU773618B2 (https=) |
| CA (1) | CA2356959C (https=) |
| DE (1) | DE69924004T2 (https=) |
| WO (1) | WO2000037050A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US7037528B2 (en) | 2000-12-22 | 2006-05-02 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| BR0212833A (pt) | 2001-09-26 | 2004-10-13 | Baxter Int | Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| WO2004096229A1 (ja) * | 2003-04-30 | 2004-11-11 | Dainippon Sumitomo Pharma Co., Ltd. | 溶液医薬組成物 |
| US20050020534A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites |
| US20050256097A1 (en) * | 2004-05-11 | 2005-11-17 | Kosan Biosciences, Inc. | Pharmaceutical solution formulations containing 17-AAG |
| ATE515288T1 (de) * | 2004-09-24 | 2011-07-15 | Rfe Pharma Llc | Carboxy-amido-triazole zur lokalisierten behandlung von augenerkrankungen |
| US20160106717A1 (en) | 2004-09-24 | 2016-04-21 | Gen Pharma Holdings LLC | Cai-based systems and methods for the localized treatment of uveitis |
| AU2013204188B2 (en) * | 2005-02-18 | 2017-01-12 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| AU2006230447A1 (en) | 2005-03-30 | 2006-10-05 | Conforma Therapeutics Corporation | Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors |
| WO2008055386A1 (fr) * | 2006-11-10 | 2008-05-15 | Shenzhen Shengeryimei Biotech Co., Ltd. | Composition pharmaceutique hydrosoluble pour injection de 17-allyl amino-17-déméthoxy geldanamycine (17-aag) |
| PE20081506A1 (es) | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| GB2451811A (en) | 2007-08-09 | 2009-02-18 | Ems Sa | Delivery composition for solubilising water-insoluble pharmaceutical active ingredients |
| EP2525819B1 (en) * | 2010-01-19 | 2018-06-06 | Robert Coifman | Immunotherapy compositions and methods of treatment |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55111469A (en) * | 1979-02-19 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient |
| FR2609631A1 (fr) * | 1987-01-15 | 1988-07-22 | Sanofi Sa | Compositions liquides stables a base de bithionol |
| EP0467954B1 (en) * | 1989-03-31 | 1996-05-01 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| DE4125255A1 (de) * | 1991-07-31 | 1993-02-04 | Knoll Ag | Prostaglandin e (pfeil abwaerts)1(pfeil abwaerts)-formulierung |
| AU688782B2 (en) * | 1993-09-30 | 1998-03-19 | Wyeth | Rapamycin formulations for oral administration |
| GB9500116D0 (en) * | 1995-01-05 | 1995-03-01 | Ciba Geigy Ag | Pharmaceutical compositions |
| DE69633566T2 (de) * | 1995-07-21 | 2005-12-08 | Savvipharm Inc. | Orotatsalze von 5-amino- oder substituierten amino-1,2,3-triazolen zur behandlung von neoplasmen |
| US5877205A (en) * | 1996-06-28 | 1999-03-02 | Board Of Regents, The University Of Texas System | Parenteral paclitaxel in a stable non-toxic formulation |
| US6110492A (en) * | 1997-05-28 | 2000-08-29 | Jenner Biotherapies, Inc. | Immunogenic compositions |
| WO2000002534A1 (fr) * | 1998-07-10 | 2000-01-20 | Welfide Corporation | Kit a preparer avant usage avec preparation contenant un medicament et solvant destine a cette fin |
-
1999
- 1999-12-22 AU AU31278/00A patent/AU773618B2/en not_active Ceased
- 1999-12-22 EP EP99965336A patent/EP1140017B9/en not_active Expired - Lifetime
- 1999-12-22 AT AT99965336T patent/ATE289801T1/de not_active IP Right Cessation
- 1999-12-22 CA CA002356959A patent/CA2356959C/en not_active Expired - Fee Related
- 1999-12-22 DE DE69924004T patent/DE69924004T2/de not_active Expired - Lifetime
- 1999-12-22 WO PCT/US1999/030631 patent/WO2000037050A1/en not_active Ceased
- 1999-12-22 JP JP2000589161A patent/JP2002532535A/ja active Pending
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