JP2002532382A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002532382A5 JP2002532382A5 JP2000568511A JP2000568511A JP2002532382A5 JP 2002532382 A5 JP2002532382 A5 JP 2002532382A5 JP 2000568511 A JP2000568511 A JP 2000568511A JP 2000568511 A JP2000568511 A JP 2000568511A JP 2002532382 A5 JP2002532382 A5 JP 2002532382A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- vegf
- agonist
- hypertension
- native
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 15
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 15
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- 239000000556 agonist Substances 0.000 description 10
- 239000002870 angiogenesis inducing agent Substances 0.000 description 8
- 206010020772 Hypertension Diseases 0.000 description 7
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 5
- 229960002897 heparin Drugs 0.000 description 5
- 229920000669 heparin Polymers 0.000 description 5
- 102000005862 Angiotensin II Human genes 0.000 description 2
- 101800000733 Angiotensin-2 Proteins 0.000 description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 2
- 229950006323 angiotensin ii Drugs 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 150000003384 small molecules Chemical group 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 208000007530 Essential hypertension Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9969498P | 1998-09-09 | 1998-09-09 | |
| US60/099,694 | 1998-09-09 | ||
| US12640699P | 1999-03-26 | 1999-03-26 | |
| US60/126,406 | 1999-03-26 | ||
| US12661599P | 1999-03-27 | 1999-03-27 | |
| US60/126,615 | 1999-03-27 | ||
| PCT/US1999/020481 WO2000013703A2 (en) | 1998-09-09 | 1999-09-09 | Methods of treating hypertension and compositions for use therein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002532382A JP2002532382A (ja) | 2002-10-02 |
| JP2002532382A5 true JP2002532382A5 (https=) | 2006-10-26 |
Family
ID=27378887
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000568511A Pending JP2002532382A (ja) | 1998-09-09 | 1999-09-09 | 高血圧を処置する方法およびそこでの使用のための組成物 |
| JP2000568510A Pending JP2002524421A (ja) | 1998-09-09 | 1999-09-09 | 微小血管障害の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000568510A Pending JP2002524421A (ja) | 1998-09-09 | 1999-09-09 | 微小血管障害の処置 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6352975B1 (https=) |
| EP (2) | EP1112083B1 (https=) |
| JP (2) | JP2002532382A (https=) |
| AT (2) | ATE260675T1 (https=) |
| AU (2) | AU5910599A (https=) |
| BR (2) | BR9913533A (https=) |
| CA (2) | CA2340320C (https=) |
| DE (2) | DE69912815T2 (https=) |
| DK (2) | DK1109571T3 (https=) |
| ES (2) | ES2216630T3 (https=) |
| IL (2) | IL141686A0 (https=) |
| PT (2) | PT1109571E (https=) |
| WO (2) | WO2000013702A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2216630T3 (es) * | 1998-09-09 | 2004-10-16 | Scios Inc | Metodos de tratar la hipertension dependiente de la sal. |
| US6783954B2 (en) * | 1999-03-05 | 2004-08-31 | Compugen Ltd. | VEGF nucleic acid and amino acid sequences |
| US7078382B1 (en) | 1999-11-02 | 2006-07-18 | Genentech, Inc. | Modulation of eNOS activity and therapeutic uses thereof |
| IL148674A0 (en) * | 1999-11-02 | 2002-09-12 | Genentech Inc | Modulation of enos activity and therapeutic uses thereof |
| US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
| US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| US7820178B2 (en) | 2001-08-01 | 2010-10-26 | University of Brisol | VEGF isoforms and their use as anti-angiogenic, anti-vasodilatory, anti-permeability and anti-proliferative agents |
| WO2003015605A2 (en) * | 2001-08-20 | 2003-02-27 | University Of Virginia Patent Foundation | Use of s-nitrosothiol signaling to treat disordered control of breathing |
| US7981863B2 (en) * | 2001-09-19 | 2011-07-19 | Neuronova Ab | Treatment of Parkinson's disease with PDGF |
| US7795213B2 (en) | 2001-12-13 | 2010-09-14 | Posco | Methods of contacting β amyloid protein with VEGF |
| US20030171556A1 (en) * | 2001-12-13 | 2003-09-11 | Chi-Bom Chae | Beta-amyloid binding factors and inhibitors thereof |
| US7335362B2 (en) | 2002-07-19 | 2008-02-26 | Beth Israel Deaconess Medical Center | Methods of treating pre-eclampsia or eclampsia |
| JP2006068401A (ja) * | 2004-09-03 | 2006-03-16 | Kyushu Institute Of Technology | 人工血管 |
| US7893244B2 (en) * | 2005-04-12 | 2011-02-22 | Intradigm Corporation | Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases |
| JP2008537752A (ja) * | 2005-04-12 | 2008-09-25 | イントラディグム コーポレイション | がんおよび他の新血管形成疾患を処置するためのＲＮＡｉ治療用の組成物および方法 |
| EP1964568B1 (en) * | 2005-08-31 | 2014-03-26 | National University Corporation Kagawa University | Utilization of hypertension/hypercardia-preventing effect of d-allose |
| ES2600781T3 (es) | 2008-12-04 | 2017-02-10 | Curna, Inc. | Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf |
| GB0921525D0 (en) * | 2009-12-08 | 2010-01-27 | Isis Innovation | Product and method |
| AU2018244776B2 (en) | 2017-03-30 | 2023-12-14 | Wake Forest University Health Sciences | Methods of treatment for kidney disease |
| CN113418940B (zh) * | 2021-06-24 | 2023-03-14 | 电子科技大学 | 一种基于x射线示踪颗粒的检测方法及检测装置 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456550A (en) | 1982-11-22 | 1984-06-26 | President And Fellows Of Harvard College | Vascular permeability factor |
| US5240848A (en) | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
| WO1990011084A1 (en) | 1989-03-24 | 1990-10-04 | The Regents Of The University Of California | Endothelial cell growth factor, isolation and expression |
| US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| US5219739A (en) | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
| US5194596A (en) | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5240714A (en) * | 1989-08-29 | 1993-08-31 | Rof Jose M S | Non-digoxin-like Na+, K+ -ATPase inhibitory factor |
| US5318957A (en) * | 1992-09-02 | 1994-06-07 | The United States Of America As Represented By The Department Of Health And Human Services | Method of stimulating angiogenesis |
| EP0941116B1 (en) * | 1996-11-01 | 2005-01-19 | Ark Therapeutics Limited | Use of vegf for the manufacture of a medicament for the treatment or prevention of intimal hyperplasia and delivery device |
| US6485942B1 (en) * | 1997-02-14 | 2002-11-26 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production |
| ES2216630T3 (es) * | 1998-09-09 | 2004-10-16 | Scios Inc | Metodos de tratar la hipertension dependiente de la sal. |
-
1999
- 1999-09-09 ES ES99968631T patent/ES2216630T3/es not_active Expired - Lifetime
- 1999-09-09 JP JP2000568511A patent/JP2002532382A/ja active Pending
- 1999-09-09 AT AT99968631T patent/ATE260675T1/de not_active IP Right Cessation
- 1999-09-09 JP JP2000568510A patent/JP2002524421A/ja active Pending
- 1999-09-09 IL IL14168699A patent/IL141686A0/xx unknown
- 1999-09-09 DK DK99968631T patent/DK1109571T3/da active
- 1999-09-09 CA CA002340320A patent/CA2340320C/en not_active Expired - Fee Related
- 1999-09-09 ES ES99946776T patent/ES2211165T3/es not_active Expired - Lifetime
- 1999-09-09 DE DE69912815T patent/DE69912815T2/de not_active Expired - Fee Related
- 1999-09-09 DE DE69915310T patent/DE69915310T2/de not_active Expired - Fee Related
- 1999-09-09 AU AU59105/99A patent/AU5910599A/en not_active Abandoned
- 1999-09-09 EP EP99946776A patent/EP1112083B1/en not_active Expired - Lifetime
- 1999-09-09 PT PT99968631T patent/PT1109571E/pt unknown
- 1999-09-09 CA CA002340728A patent/CA2340728C/en not_active Expired - Fee Related
- 1999-09-09 EP EP99968631A patent/EP1109571B1/en not_active Expired - Lifetime
- 1999-09-09 AT AT99946776T patent/ATE253934T1/de not_active IP Right Cessation
- 1999-09-09 BR BR9913533-7A patent/BR9913533A/pt not_active Application Discontinuation
- 1999-09-09 US US09/392,932 patent/US6352975B1/en not_active Expired - Lifetime
- 1999-09-09 BR BR9913564-7A patent/BR9913564A/pt not_active Application Discontinuation
- 1999-09-09 DK DK99946776T patent/DK1112083T3/da active
- 1999-09-09 WO PCT/US1999/020480 patent/WO2000013702A2/en not_active Ceased
- 1999-09-09 WO PCT/US1999/020481 patent/WO2000013703A2/en not_active Ceased
- 1999-09-09 PT PT99946776T patent/PT1112083E/pt unknown
- 1999-09-09 AU AU60285/99A patent/AU6028599A/en not_active Abandoned
- 1999-09-09 IL IL14168799A patent/IL141687A0/xx unknown
-
2002
- 2002-02-26 US US10/083,817 patent/US20020193288A1/en not_active Abandoned
-
2003
- 2003-12-31 US US10/749,706 patent/US20040224885A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002532382A5 (https=) | ||
| Timpl et al. | [47] Laminin | |
| Mollenhauer et al. | Isolation and characterization of a collagen‐binding glycoprotein from chondrocyte membranes. | |
| Avnur et al. | The removal of extracellular fibronectin from areas of cell-substrate contact | |
| Mann et al. | Solubilization of protein BM‐40 from a basement membrane tumor with cheating agents and evidence for its identity with osteonectin and SPARC | |
| Power et al. | Intra‐articular injection of rhFGF‐18 improves the healing in microfracture treated chondral defects in an ovine model | |
| Vogel et al. | Proteins in the tensile region of adult bovine deep flexor tendon. | |
| KR920703642A (ko) | 사람 인터루킨-4의 항체 길항제 | |
| JP2002527052A5 (https=) | ||
| NO975435L (no) | Modifiserte/kimeriske proteiner samt anvendelse derav | |
| EA199900262A1 (ru) | Ангиогенный фактор и способ его применения в лечении сердечно-сосудистого заболевания | |
| PL1626985T3 (pl) | Generowanie sztucznych białek wiążących na bazie białek ubikwitynowych | |
| JP2002517245A5 (https=) | ||
| Center | Chronic liver disease: current concepts of disease mechanisms | |
| Nakatani et al. | Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis | |
| Cahill et al. | Vascular atrial natriuretic factor receptor subtypes are not independently regulated by atrial peptides. | |
| FR2816410B1 (fr) | Necessaire de detection de la proteine esm-1 et procede de detection mettant en oeuvre ledit necessaire | |
| Duzen et al. | Identification of specific amino acid residues in the E. coli β processivity clamp involved in interactions with DNA polymerase III, UmuD and UmuD′ | |
| Zippel et al. | In vivo phosphorylation and dephosphorylation of the platelet-derived growth factor receptor studied by immunoblot analysis with phosphotyrosine antibodies | |
| WO2002058589A3 (en) | Agents and methods for promoting bone growth | |
| Khew et al. | The specific recognition of a cell binding sequence derived from type I collagen by Hep3B and L929 cells | |
| WO1994014471A9 (en) | Methods and compositions for inhibition of hepatic clearance of tissue-type plasminogen activator | |
| Yurchenco et al. | Laminin Self-Assembly: A Three-Arm Interaction Hypothesis for the Formation | |
| Shaeffer et al. | Differential effects of ubiquitin aldehyde on ubiquitin and ATP-dependent protein degradation | |
| Potter et al. | Effects of differing purification methods on properties of keratose biomaterials |