JP2002525327A - 原発性頭痛障害の治療のためのプロスタノイドアンタゴニストの使用 - Google Patents
原発性頭痛障害の治療のためのプロスタノイドアンタゴニストの使用Info
- Publication number
- JP2002525327A JP2002525327A JP2000571923A JP2000571923A JP2002525327A JP 2002525327 A JP2002525327 A JP 2002525327A JP 2000571923 A JP2000571923 A JP 2000571923A JP 2000571923 A JP2000571923 A JP 2000571923A JP 2002525327 A JP2002525327 A JP 2002525327A
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- antagonists
- treatment
- use according
- prostanoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2807—Headache; Migraine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Slide Fasteners, Snap Fasteners, And Hook Fasteners (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9720270.9A GB9720270D0 (en) | 1997-09-25 | 1997-09-25 | Medicaments for the treatment of migraine |
| PCT/GB1998/002895 WO2000018405A1 (en) | 1997-09-25 | 1998-09-25 | Use of prostanoid antagonists for the treatment of primary headache disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009235310A Division JP2010047583A (ja) | 2009-10-09 | 2009-10-09 | 原発性頭痛障害の治療のためのプロスタノイドアンタゴニストの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002525327A true JP2002525327A (ja) | 2002-08-13 |
| JP2002525327A5 JP2002525327A5 (OSRAM) | 2006-01-05 |
Family
ID=26312305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000571923A Pending JP2002525327A (ja) | 1997-09-25 | 1998-09-25 | 原発性頭痛障害の治療のためのプロスタノイドアンタゴニストの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8513027B2 (OSRAM) |
| EP (1) | EP1115404B1 (OSRAM) |
| JP (1) | JP2002525327A (OSRAM) |
| AT (1) | ATE257707T1 (OSRAM) |
| AU (1) | AU757265B2 (OSRAM) |
| CA (1) | CA2345248C (OSRAM) |
| DE (1) | DE69821142T2 (OSRAM) |
| DK (1) | DK1115404T3 (OSRAM) |
| ES (1) | ES2213914T3 (OSRAM) |
| GB (2) | GB9720270D0 (OSRAM) |
| PT (1) | PT1115404E (OSRAM) |
| WO (1) | WO2000018405A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720270D0 (en) | 1997-09-25 | 1997-11-26 | Pharmagene Lab Limited | Medicaments for the treatment of migraine |
| AU3445100A (en) * | 2000-03-24 | 2001-10-08 | Pharmagene Lab Ltd | Use of prostanoid ep4 receptor antagonists for the treatment of headache and assays for such antagonists |
| DE60222168T2 (de) * | 2001-10-31 | 2008-05-15 | Medical Research Council | Antagonisten der prostaglandin ep2 und/oder ep4 rezeptoren zur behandlung von menorrhagie |
| IL163720A0 (en) * | 2002-02-26 | 2005-12-18 | Ortho Mcneil Pharm Inc | Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| EP2846793A1 (en) | 2012-05-09 | 2015-03-18 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2028805B (en) | 1978-07-11 | 1982-11-03 | Glaxo Group Ltd | Prostanoid compounds |
| IL62734A (en) * | 1980-04-30 | 1985-10-31 | Glaxo Group Ltd | Aminocyclopentane alkenoic acids and esters,their preparation and pharmaceutical formulations |
| US4839384A (en) * | 1988-10-07 | 1989-06-13 | E. R. Squibb & Sons, Inc. | Method of inhibiting onset of or treating migraine headache using a thromboxane A2 receptor antagonist |
| US5182272A (en) | 1991-05-03 | 1993-01-26 | G. D. Searle & Co. | 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain |
| ATE194987T1 (de) | 1991-05-03 | 2000-08-15 | Searle & Co | Substituierte dibenzoxazepinverbindungen, pharmazeutische zusammensetzungen und anwendungsmethoden |
| US5212169A (en) | 1991-10-31 | 1993-05-18 | G. D. Searle & Co. | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain |
| AU2669992A (en) | 1991-11-05 | 1993-06-07 | G.D. Searle & Co. | 10-acyl-dibenz(b,f) (1,4)-oxazepines and their thiazepines analo gues useful as prostaglandin antagonists |
| WO1993013082A1 (en) | 1991-12-20 | 1993-07-08 | G.D. Searle & Co. | Substituted dibenzoxazepines or dibenzothiazepines and their use as prostaglandin e2 antagonists |
| US5266571A (en) * | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
| US5395932A (en) | 1993-04-30 | 1995-03-07 | G. D. Searle & Co. | 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| US5344991A (en) * | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
| US5488046A (en) | 1993-11-03 | 1996-01-30 | G. D. Searle & Co. | Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| JPH09506894A (ja) | 1993-12-20 | 1997-07-08 | 藤沢薬品工業株式会社 | ４，５−ジアリールオキサゾール誘導体 |
| KR100383305B1 (ko) | 1994-03-10 | 2003-11-01 | 후지사와 야꾸힝 고교 가부시키가이샤 | 프로스타글란딘i₂작용물질로서의나프탈렌유도체 |
| TW401408B (en) | 1995-07-21 | 2000-08-11 | Fujisawa Pharmaceutical Co | Heterocyclic compounds having prostaglandin I2 agonism |
| AUPO713297A0 (en) | 1997-06-02 | 1997-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compound |
| GB9720270D0 (en) | 1997-09-25 | 1997-11-26 | Pharmagene Lab Limited | Medicaments for the treatment of migraine |
| US20030158240A1 (en) * | 1998-09-25 | 2003-08-21 | Pharmagene Laboratories Limited | Methods for the treatment of primary headache disorders using prostanoid EP4 receptor antagonists, and assays for agents for such treatment |
| EP1071648A2 (en) | 1998-03-13 | 2001-01-31 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| CA2346038A1 (en) | 1998-10-15 | 2000-04-20 | Merck & Co., Inc. | Methods for inhibiting bone resorption |
| ATE348608T1 (de) | 1999-08-10 | 2007-01-15 | Glaxo Group Ltd | Ep4 rezeptor ligand und verwendung gegen neuropatischen schmerzen, colon krebs, hiv und migräne |
| CA2565628A1 (en) | 2004-05-03 | 2005-11-10 | Astellas Pharma Inc. | The combination of prostaglandin e2 receptor antagonist and renin-angiotensin system inhibitor for treating renal diseases |
-
1997
- 1997-09-25 GB GBGB9720270.9A patent/GB9720270D0/en not_active Ceased
-
1998
- 1998-09-25 ES ES98944111T patent/ES2213914T3/es not_active Expired - Lifetime
- 1998-09-25 DK DK98944111T patent/DK1115404T3/da active
- 1998-09-25 GB GB9820936A patent/GB2341799B/en not_active Expired - Fee Related
- 1998-09-25 AT AT98944111T patent/ATE257707T1/de active
- 1998-09-25 PT PT98944111T patent/PT1115404E/pt unknown
- 1998-09-25 WO PCT/GB1998/002895 patent/WO2000018405A1/en not_active Ceased
- 1998-09-25 AU AU91776/98A patent/AU757265B2/en not_active Ceased
- 1998-09-25 EP EP98944111A patent/EP1115404B1/en not_active Expired - Lifetime
- 1998-09-25 JP JP2000571923A patent/JP2002525327A/ja active Pending
- 1998-09-25 DE DE69821142T patent/DE69821142T2/de not_active Expired - Lifetime
- 1998-09-25 CA CA002345248A patent/CA2345248C/en not_active Expired - Fee Related
-
2007
- 2007-10-30 US US11/976,945 patent/US8513027B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69821142D1 (de) | 2004-02-19 |
| GB9820936D0 (en) | 1998-11-18 |
| EP1115404B1 (en) | 2004-01-14 |
| EP1115404A1 (en) | 2001-07-18 |
| CA2345248C (en) | 2008-03-18 |
| US8513027B2 (en) | 2013-08-20 |
| CA2345248A1 (en) | 2000-04-06 |
| PT1115404E (pt) | 2004-05-31 |
| AU757265B2 (en) | 2003-02-13 |
| GB9720270D0 (en) | 1997-11-26 |
| DK1115404T3 (da) | 2004-04-13 |
| ATE257707T1 (de) | 2004-01-15 |
| AU9177698A (en) | 2000-04-17 |
| US20080247954A1 (en) | 2008-10-09 |
| GB2341799B (en) | 2000-08-16 |
| DE69821142T2 (de) | 2004-11-11 |
| ES2213914T3 (es) | 2004-09-01 |
| GB2341799A (en) | 2000-03-29 |
| WO2000018405A1 (en) | 2000-04-06 |
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