JP2002524393A5 - - Google Patents
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- Publication number
- JP2002524393A5 JP2002524393A5 JP2000563294A JP2000563294A JP2002524393A5 JP 2002524393 A5 JP2002524393 A5 JP 2002524393A5 JP 2000563294 A JP2000563294 A JP 2000563294A JP 2000563294 A JP2000563294 A JP 2000563294A JP 2002524393 A5 JP2002524393 A5 JP 2002524393A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- condition
- peptide antagonist
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 16
- 229940083963 Peptide antagonist Drugs 0.000 description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 210000001578 tight junction Anatomy 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 108700012359 toxins Proteins 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 102100025255 Haptoglobin Human genes 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 108010027843 zonulin Proteins 0.000 description 2
- -1 Amino Chemical group 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010048962 Brain oedema Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010064147 Gastrointestinal inflammation Diseases 0.000 description 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 102000000591 Tight Junction Proteins Human genes 0.000 description 1
- 108010002321 Tight Junction Proteins Proteins 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/127,815 US6458925B1 (en) | 1998-08-03 | 1998-08-03 | Peptide antagonists of zonulin and methods for use of the same |
| US09/127,815 | 1998-08-03 | ||
| PCT/US1999/016683 WO2000007609A1 (en) | 1998-08-03 | 1999-07-28 | Peptide antagonists of zonulin and methods for use of the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002524393A JP2002524393A (ja) | 2002-08-06 |
| JP2002524393A5 true JP2002524393A5 (https=) | 2006-09-14 |
| JP4822585B2 JP4822585B2 (ja) | 2011-11-24 |
Family
ID=22432094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000563294A Expired - Lifetime JP4822585B2 (ja) | 1998-08-03 | 1999-07-28 | ゾヌリンのペプチドアンタゴニストおよびその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (10) | US6458925B1 (https=) |
| EP (2) | EP1698345B1 (https=) |
| JP (1) | JP4822585B2 (https=) |
| KR (1) | KR100610389B1 (https=) |
| CN (2) | CN100348266C (https=) |
| AT (2) | ATE329606T1 (https=) |
| AU (1) | AU745507B2 (https=) |
| CA (1) | CA2338005C (https=) |
| DE (2) | DE69942753D1 (https=) |
| DK (1) | DK1102596T3 (https=) |
| ES (1) | ES2267282T3 (https=) |
| HU (1) | HU228079B1 (https=) |
| IL (2) | IL141082A0 (https=) |
| NO (1) | NO326552B1 (https=) |
| NZ (1) | NZ509579A (https=) |
| RU (1) | RU2214267C2 (https=) |
| WO (1) | WO2000007609A1 (https=) |
| ZA (1) | ZA200100829B (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458925B1 (en) * | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| AU2001249067A1 (en) * | 2000-05-19 | 2001-12-03 | University Of Maryland, Baltimore | Method of use of peptide antagonists of zonulin to prevent or delay the onset ofdiabetes |
| FR2844201A1 (fr) * | 2002-09-06 | 2004-03-12 | Rytek | Compositions pour le traitement de pathologies fonctionnelles digestives |
| AU2003244690A1 (en) | 2002-03-15 | 2003-09-29 | Rytek | Compositions for treating digestive functional pathologies |
| KR20080056318A (ko) * | 2003-07-15 | 2008-06-20 | 유니버시티 오브 메릴랜드, 볼티모어 | Ｚｏｔ 및 조눌린에 대한 수용체의 작용제 폴리펩티드 |
| US7067385B2 (en) | 2003-09-04 | 2006-06-27 | Micron Technology, Inc. | Support for vertically oriented capacitors during the formation of a semiconductor device |
| US7125781B2 (en) * | 2003-09-04 | 2006-10-24 | Micron Technology, Inc. | Methods of forming capacitor devices |
| US20080038843A1 (en) * | 2006-08-11 | 2008-02-14 | University Of Maryland - Baltimore | Method of diagnosing celiac disease |
| US7387939B2 (en) * | 2004-07-19 | 2008-06-17 | Micron Technology, Inc. | Methods of forming semiconductor structures and capacitor devices |
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| US20060046055A1 (en) | 2004-08-30 | 2006-03-02 | Nan Ya Plastics Corporation | Superfine fiber containing grey dope dyed component and the fabric made of the same |
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| FR2879100B1 (fr) | 2004-12-09 | 2007-07-06 | Lionel Bueno | Compositions pour le traitement des pathologies oculaires de surface et de la retine |
| TW200637573A (en) * | 2005-01-14 | 2006-11-01 | Univ Maryland | Peptide for delivery of mucosal vaccines |
| US7557015B2 (en) * | 2005-03-18 | 2009-07-07 | Micron Technology, Inc. | Methods of forming pluralities of capacitors |
| GB2425654B (en) * | 2005-04-29 | 2010-03-17 | Seiko Epson Corp | A method of fabricating a heterojunction of organic semiconducting polymers |
| EP1722466A1 (en) * | 2005-05-13 | 2006-11-15 | STMicroelectronics S.r.l. | Method and relative circuit for generating a control voltage of a synchronous rectifier |
| US7544563B2 (en) | 2005-05-18 | 2009-06-09 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| US7517753B2 (en) * | 2005-05-18 | 2009-04-14 | Micron Technology, Inc. | Methods of forming pluralities of capacitors |
| AR057058A1 (es) * | 2005-06-09 | 2007-11-14 | Alba Therapeutics Corp | Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas |
| US7282401B2 (en) | 2005-07-08 | 2007-10-16 | Micron Technology, Inc. | Method and apparatus for a self-aligned recessed access device (RAD) transistor gate |
| US7199005B2 (en) * | 2005-08-02 | 2007-04-03 | Micron Technology, Inc. | Methods of forming pluralities of capacitors |
| US7867851B2 (en) | 2005-08-30 | 2011-01-11 | Micron Technology, Inc. | Methods of forming field effect transistors on substrates |
| US7700441B2 (en) | 2006-02-02 | 2010-04-20 | Micron Technology, Inc. | Methods of forming field effect transistors, methods of forming field effect transistor gates, methods of forming integrated circuitry comprising a transistor gate array and circuitry peripheral to the gate array, and methods of forming integrated circuitry comprising a transistor gate array including first gates and second grounded isolation gates |
| MX2008010221A (es) | 2006-02-09 | 2009-03-05 | Alba Therapeutics Corp | Formulaciones para un efector de union ajustada. |
| US7557013B2 (en) | 2006-04-10 | 2009-07-07 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| US7602001B2 (en) | 2006-07-17 | 2009-10-13 | Micron Technology, Inc. | Capacitorless one transistor DRAM cell, integrated circuitry comprising an array of capacitorless one transistor DRAM cells, and method of forming lines of capacitorless one transistor DRAM cells |
| US7772632B2 (en) | 2006-08-21 | 2010-08-10 | Micron Technology, Inc. | Memory arrays and methods of fabricating memory arrays |
| US7589995B2 (en) | 2006-09-07 | 2009-09-15 | Micron Technology, Inc. | One-transistor memory cell with bias gate |
| WO2008043107A2 (en) * | 2006-10-06 | 2008-04-10 | Alba Therapeutics Corporation | Use of tight junction antagonists to treat inflammatory bowel disease |
| US7902081B2 (en) | 2006-10-11 | 2011-03-08 | Micron Technology, Inc. | Methods of etching polysilicon and methods of forming pluralities of capacitors |
| US8034776B2 (en) * | 2006-10-26 | 2011-10-11 | Alba Therapeutics Corporation | Materials and methods for the treatment of celiac disease |
| US20100144646A1 (en) * | 2006-11-03 | 2010-06-10 | Blake Paterson | Method of diagnosing and treating asthma |
| US7785962B2 (en) | 2007-02-26 | 2010-08-31 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| WO2009023311A2 (en) * | 2007-05-07 | 2009-02-19 | Alba Therapeutics Corporation | Transcutaneous delivery of therapeutic agents |
| WO2008150981A2 (en) * | 2007-05-30 | 2008-12-11 | Alba Therapeutics Corporation | Novel short peptides that inhibit the opening of mammalian tight junctions |
| US7923373B2 (en) | 2007-06-04 | 2011-04-12 | Micron Technology, Inc. | Pitch multiplication using self-assembling materials |
| WO2008154493A2 (en) * | 2007-06-07 | 2008-12-18 | Alba Therapeutics Corporation | Novel peptides that inhibit the opening of mammalian tight junctions |
| WO2008154350A2 (en) * | 2007-06-08 | 2008-12-18 | Alba Therapeutics Corporation | Use of tight junction agonists to suppress immune responses |
| US20110201543A1 (en) * | 2007-06-29 | 2011-08-18 | Blake Paterson | Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress |
| US8198233B2 (en) | 2007-07-26 | 2012-06-12 | Alba Therapeutics Corporation | Synthetic peptides that enhance tight junction permeability |
| US7682924B2 (en) | 2007-08-13 | 2010-03-23 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| WO2009052489A2 (en) * | 2007-10-19 | 2009-04-23 | Alba Therapeutics Corporation | Novel inhibitors of mammalian tight junction opening |
| EP2062909A1 (en) * | 2007-11-21 | 2009-05-27 | SOLVAY (Société Anonyme) | Peptide production and purification process |
| US9051349B2 (en) | 2007-11-21 | 2015-06-09 | Alba Therapeutics Corporation | Larazotide acetate compositions |
| WO2009110947A2 (en) * | 2007-12-19 | 2009-09-11 | Alba Therapeutics Corporation | Compositions and methods for inhibiting cytokine production |
| US8388851B2 (en) | 2008-01-08 | 2013-03-05 | Micron Technology, Inc. | Capacitor forming methods |
| US8274777B2 (en) * | 2008-04-08 | 2012-09-25 | Micron Technology, Inc. | High aspect ratio openings |
| WO2009137572A2 (en) * | 2008-05-06 | 2009-11-12 | Alba Therapeutics Corporation | Inhibition of gliadin peptides |
| US7759193B2 (en) | 2008-07-09 | 2010-07-20 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| CN102481362A (zh) * | 2009-06-10 | 2012-05-30 | 马里兰巴尔的摩大学 | 表皮生长因子受体(egfr)与蛋白酶活化受体2(par2)对肠道通透性的调节 |
| RU2410765C1 (ru) * | 2009-07-21 | 2011-01-27 | Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Федерального агентства по здравоохранению и социальному развитию | Способ профилактики токсического действия никеля у экспериментальных животных при хроническом отравлении |
| RU2412489C1 (ru) * | 2009-09-01 | 2011-02-20 | Государственное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Федерального агентства по здравоохранению и социальному развитию | Способ профилактики хронической токсической кардиопатии у экспериментальных животных |
| US8518788B2 (en) | 2010-08-11 | 2013-08-27 | Micron Technology, Inc. | Methods of forming a plurality of capacitors |
| US9076680B2 (en) | 2011-10-18 | 2015-07-07 | Micron Technology, Inc. | Integrated circuitry, methods of forming capacitors, and methods of forming integrated circuitry comprising an array of capacitors and circuitry peripheral to the array |
| US8946043B2 (en) | 2011-12-21 | 2015-02-03 | Micron Technology, Inc. | Methods of forming capacitors |
| SI3677252T1 (sl) | 2012-03-19 | 2024-02-29 | Cidara Therapeutics, Inc. | Sheme odmerjanja za spojine iz razreda ehinokandinov |
| US8652926B1 (en) | 2012-07-26 | 2014-02-18 | Micron Technology, Inc. | Methods of forming capacitors |
| WO2015069718A2 (en) | 2013-11-05 | 2015-05-14 | Bio-Rad Laboratories, Inc. | Pre-haptoglobin-2 monoclonal antibodies and uses thereof |
| EP3125870A4 (en) * | 2014-04-04 | 2017-12-13 | Alba Therapeutics Corporation | Methods of treating celiac disease with larazotide |
| US11058902B2 (en) | 2017-02-10 | 2021-07-13 | 9 Meters Biopharma, Inc. | Compositions and methods for treating disease associated with permeability of intestinal epithelium |
| WO2019165346A1 (en) | 2018-02-23 | 2019-08-29 | Innovate Biopharmaceuticals, Inc. | Compounds and methods for treating tight junction permeability |
| EP4326304A1 (en) | 2021-04-19 | 2024-02-28 | Ebris S.r.l. | Zonulin antagonists for the treatment of multisystem inflammatory syndrome in children (mis-c) and adults (mis-a) |
| CN118873629B (zh) * | 2024-09-27 | 2024-12-10 | 北京大学口腔医学院 | 醋酸拉唑肽在制备促进成骨药物中的用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US667048A (en) * | 1900-07-06 | 1901-01-29 | Edson F Whitman | Torpedo-projectile. |
| US2419898A (en) | 1943-12-10 | 1947-04-29 | Int Harvester Co | Shelled corn saver for husking devices |
| US5395750A (en) * | 1992-02-28 | 1995-03-07 | Hoffmann-La Roche Inc. | Methods for producing proteins which bind to predetermined antigens |
| AU5896394A (en) * | 1992-11-10 | 1994-06-08 | Washington University | Pars planitis specific polypeptides |
| WO1994011508A2 (en) * | 1992-11-13 | 1994-05-26 | Cancer Research Fund Of Contra Costa | Polypeptides with specificity for neoplasias, kit, and diagnostic, vaccination, and therapeutic methods |
| EP0674710B1 (en) * | 1992-11-16 | 2003-05-02 | Cancer Research Fund Of Contra Costa | Peptides with broad neoplastic specificity |
| JP2996864B2 (ja) * | 1994-03-30 | 2000-01-11 | 寳酒造株式会社 | 抗体可変領域ｄｎａ |
| US5665389A (en) | 1995-05-24 | 1997-09-09 | University Of Maryland At Baltimore | Oral dosage composition for intestinal delivery and method of treating diabetes |
| NZ331866A (en) * | 1996-03-15 | 2000-05-26 | Corixa Corp | Compounds for immunotherapy and immunodiagnosis of prostate cancer |
| US5912323A (en) * | 1997-02-20 | 1999-06-15 | University Of Maryland, Baltimore | Zonula occludens toxin receptors |
| US5945510A (en) * | 1997-05-21 | 1999-08-31 | University Of Maryland, Baltimore | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
| US6506577B1 (en) * | 1998-03-19 | 2003-01-14 | The Regents Of The University Of California | Synthesis and crosslinking of catechol containing copolypeptides |
| US6458925B1 (en) * | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| DE69925496T2 (de) * | 1998-09-14 | 2006-02-02 | University Of Maryland, Baltimore | In-vitro verfahren zur verwendung von zot oder zonulin zur inhibierung der lymphozyten proliferation in einer antigen-spezifischen weise |
| AU2001249067A1 (en) * | 2000-05-19 | 2001-12-03 | University Of Maryland, Baltimore | Method of use of peptide antagonists of zonulin to prevent or delay the onset ofdiabetes |
| US8034776B2 (en) * | 2006-10-26 | 2011-10-11 | Alba Therapeutics Corporation | Materials and methods for the treatment of celiac disease |
-
1998
- 1998-08-03 US US09/127,815 patent/US6458925B1/en not_active Expired - Lifetime
-
1999
- 1999-07-28 IL IL14108299A patent/IL141082A0/xx unknown
- 1999-07-28 DE DE69942753T patent/DE69942753D1/de not_active Expired - Lifetime
- 1999-07-28 EP EP06006483A patent/EP1698345B1/en not_active Expired - Lifetime
- 1999-07-28 AT AT99940809T patent/ATE329606T1/de active
- 1999-07-28 KR KR1020017001503A patent/KR100610389B1/ko not_active Expired - Lifetime
- 1999-07-28 DK DK99940809T patent/DK1102596T3/da active
- 1999-07-28 CN CNB2005100077127A patent/CN100348266C/zh not_active Expired - Lifetime
- 1999-07-28 AU AU54590/99A patent/AU745507B2/en not_active Expired
- 1999-07-28 DE DE69931929T patent/DE69931929T2/de not_active Expired - Lifetime
- 1999-07-28 RU RU2001106615/14A patent/RU2214267C2/ru active
- 1999-07-28 AT AT06006483T patent/ATE480252T1/de not_active IP Right Cessation
- 1999-07-28 EP EP99940809A patent/EP1102596B1/en not_active Expired - Lifetime
- 1999-07-28 WO PCT/US1999/016683 patent/WO2000007609A1/en not_active Ceased
- 1999-07-28 HU HU0103321A patent/HU228079B1/hu unknown
- 1999-07-28 CA CA2338005A patent/CA2338005C/en not_active Expired - Lifetime
- 1999-07-28 CN CN998100315A patent/CN1217697C/zh not_active Expired - Lifetime
- 1999-07-28 NZ NZ509579A patent/NZ509579A/en not_active IP Right Cessation
- 1999-07-28 JP JP2000563294A patent/JP4822585B2/ja not_active Expired - Lifetime
- 1999-07-28 ES ES99940809T patent/ES2267282T3/es not_active Expired - Lifetime
-
2001
- 2001-01-24 IL IL141082A patent/IL141082A/en not_active IP Right Cessation
- 2001-01-30 ZA ZA2001/00829A patent/ZA200100829B/en unknown
- 2001-02-02 NO NO20010567A patent/NO326552B1/no not_active IP Right Cessation
-
2002
- 2002-03-13 US US10/095,450 patent/US6670448B2/en not_active Expired - Lifetime
-
2003
- 2003-08-27 US US10/648,642 patent/US6936689B2/en not_active Expired - Lifetime
-
2005
- 2005-03-09 US US11/074,727 patent/US7189696B2/en not_active Expired - Fee Related
-
2006
- 2006-08-08 US US11/500,429 patent/US7531504B2/en not_active Expired - Fee Related
-
2007
- 2007-08-21 US US11/842,763 patent/US7582603B2/en not_active Expired - Fee Related
- 2007-08-21 US US11/842,738 patent/US20090082279A1/en not_active Abandoned
-
2010
- 2010-10-20 US US12/908,709 patent/US20110183923A1/en not_active Abandoned
-
2013
- 2013-01-09 US US13/737,517 patent/US20130190247A1/en not_active Abandoned
- 2013-11-01 US US14/070,208 patent/US20140128328A1/en not_active Abandoned
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