JP2002523450A - ニトロソ化およびニトロシル化されたホスホジエステラーゼ阻害剤、組成物および使用方法 - Google Patents
ニトロソ化およびニトロシル化されたホスホジエステラーゼ阻害剤、組成物および使用方法Info
- Publication number
- JP2002523450A JP2002523450A JP2000567194A JP2000567194A JP2002523450A JP 2002523450 A JP2002523450 A JP 2002523450A JP 2000567194 A JP2000567194 A JP 2000567194A JP 2000567194 A JP2000567194 A JP 2000567194A JP 2002523450 A JP2002523450 A JP 2002523450A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- alkyl
- formula
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/145,142 | 1998-09-01 | ||
US09/145,142 US5958926A (en) | 1996-11-01 | 1998-09-01 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
PCT/US1999/020024 WO2000012076A1 (en) | 1998-09-01 | 1999-09-01 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002523450A true JP2002523450A (ja) | 2002-07-30 |
JP2002523450A5 JP2002523450A5 (US06316457-20011113-C00015.png) | 2006-10-19 |
Family
ID=22511772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000567194A Pending JP2002523450A (ja) | 1998-09-01 | 1999-09-01 | ニトロソ化およびニトロシル化されたホスホジエステラーゼ阻害剤、組成物および使用方法 |
Country Status (6)
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013518851A (ja) * | 2010-02-05 | 2013-05-23 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | sGC刺激剤又はsGC活性化剤単独及びPDE5阻害剤と組合せた嚢胞性線維症処置 |
JP2020520945A (ja) * | 2017-05-22 | 2020-07-16 | トパドゥール ファーマ アーゲー | 新規二重作用モード可溶性グアニル酸シクラーゼ活性化因子およびホスホジエステラーゼ阻害剤ならびにその使用 |
Families Citing this family (57)
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US5645839A (en) * | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
CA2306837C (en) * | 1997-10-28 | 2007-05-08 | Asivi, Llc. | Treatment of female sexual dysfunction |
US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
IT1301759B1 (it) * | 1998-06-19 | 2000-07-07 | Nicox Sa | Sali nitrati di farmaci antiipertensivi |
IL132460A0 (en) * | 1999-10-19 | 2001-03-19 | Laniado Shlomo | Sildenafil preparation |
US20050020547A1 (en) * | 1999-11-08 | 2005-01-27 | Pfizer Inc. | Compounds for the treatment of female sexual dysfunction |
IL139457A0 (en) | 1999-11-08 | 2001-11-25 | Pfizer | Compounds for the treatment of female sexual dysfunction |
GB0000561D0 (en) * | 2000-01-11 | 2000-03-01 | Pfizer Ltd | Treatment of diabetic ulcers |
US6476037B1 (en) * | 2000-03-23 | 2002-11-05 | The Regents Of The University Of California | L-arginine and phosphodiesterase (PDE) inhibitor synergism |
ES2291333T3 (es) | 2000-06-27 | 2008-03-01 | Qualilife Pharmaceuticals Inc. | Composiciones y metodos para el tratamiento de la respuesta sexual de las mujeres. |
IT1318673B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Farmaci per le disfunzioni sessuali. |
US6953774B2 (en) * | 2000-08-11 | 2005-10-11 | Applied Research Systems Ars Holding N.V. | Methods of inducing ovulation |
US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
CA2425489C (en) * | 2000-10-16 | 2011-05-17 | Duke University | Therapeutic use of aerosolized s-nitrosoglutathione in cystic fibrosis |
KR20100036390A (ko) | 2001-03-06 | 2010-04-07 | 셀러지 파마세우티칼스, 인크 | 비뇨생식기 장애 치료용 화합물 및 그 방법 |
EP1408757A4 (en) * | 2001-07-02 | 2006-12-27 | Wisconsin Alumni Res Found | METHOD AND COMPOSITION FOR EXTENDING DRUG STAY TIME IN INTESTINE |
US6444237B1 (en) | 2001-09-13 | 2002-09-03 | Pamela A. Heleen | Herbal composition for enhancing sexual response |
WO2003030823A2 (en) | 2001-10-05 | 2003-04-17 | Combinatorx, Incorporated | Combinations for the treatment of immunoinflammatory disorders |
EP1442042A1 (en) * | 2001-11-09 | 2004-08-04 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase v inhibitors |
US20030158184A1 (en) * | 2001-12-21 | 2003-08-21 | Garvey David S. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
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US7273616B2 (en) * | 2002-05-10 | 2007-09-25 | The Trustees Of Columbia University In The City Of New York | Genetically engineered cell lines and systems for propagating Varicella zoster virus and methods of use thereof |
CN100374441C (zh) * | 2003-06-06 | 2008-03-12 | 天津倍方科技发展有限公司 | 二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途 |
WO2005018561A2 (en) * | 2003-08-20 | 2005-03-03 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
JP2007504136A (ja) * | 2003-08-28 | 2007-03-01 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化利尿化合物、組成物、ならびに使用方法 |
TW200517114A (en) * | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
AU2005207037A1 (en) * | 2004-01-22 | 2005-08-04 | Nitromed, Inc. | Nitrosated and/or nitrosylated compounds, compositions and methods of use |
WO2006041855A2 (en) | 2004-10-04 | 2006-04-20 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
WO2006078995A1 (en) * | 2005-01-21 | 2006-07-27 | Nitromed, Inc. | Cardiovascular compounds comprising heterocyclic nitric oxide donor group compositions and methods of use |
AU2006336387A1 (en) * | 2005-02-16 | 2007-08-02 | Nicox S.A. | Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use |
US20090012057A1 (en) * | 2005-02-28 | 2009-01-08 | Nitromed, Inc. | Cardiovascular Compounds Comprising Nitric Oxide Enhancing Groups, Compositions and Methods of Use |
AU2006223392A1 (en) * | 2005-03-09 | 2006-09-21 | Nicox S.A. | Organic nitric oxide enhancing salts of angiotensin II antagonists, compositions and methods of use |
US20090048219A1 (en) * | 2005-05-23 | 2009-02-19 | Nitromed Inc. | Organic nitric oxide donor salts of nonsteroidal antiinflammatory compounds, compositions and methods of use |
US20090018091A1 (en) * | 2005-08-02 | 2009-01-15 | Nitromed, Inc. | Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use |
US20090054381A1 (en) * | 2005-10-04 | 2009-02-26 | Nitromed, Inc. | Methods for treating respiratory disorders |
EP1954685A4 (en) * | 2005-11-16 | 2009-11-11 | Nitromed Inc | FUROXANE COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
EP1968584A2 (en) * | 2005-12-20 | 2008-09-17 | Nitromed, Inc. | Nitric oxide enhancing glutamic acid compounds, compositions and methods of use |
US20080293702A1 (en) * | 2005-12-22 | 2008-11-27 | Nitromed, Inc. | Nitric Oxide Enhancing Pyruvate Compounds, Compositions and Methods of Use |
WO2007126609A1 (en) | 2006-03-29 | 2007-11-08 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
US20080003213A1 (en) * | 2006-05-22 | 2008-01-03 | Jan Lessem | Methods and compositions for the treatment of diseases or conditions associated with increased C-reactive protein, interleukin-6, or interferon-gamma levels |
US8065347B1 (en) | 2006-12-21 | 2011-11-22 | Clinphone Plc | Managing protocol amendments in electronically recorded clinical trials |
US10592999B2 (en) * | 2006-12-21 | 2020-03-17 | Clinphone Limited | Aggregation of compartmentalized clinical trial data |
EP2203174A4 (en) * | 2007-09-19 | 2010-09-29 | Combinatorx Inc | THERAPEUTIC REGIMES FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS |
MX2010006724A (es) * | 2007-12-17 | 2010-09-07 | Combinatorx Inc | Regimenes terapeuticos para el tratamiento de desordenes inmunoinflamatorios. |
US8359205B2 (en) | 2008-10-24 | 2013-01-22 | The Nielsen Company (Us), Llc | Methods and apparatus to perform audio watermarking and watermark detection and extraction |
US9667365B2 (en) | 2008-10-24 | 2017-05-30 | The Nielsen Company (Us), Llc | Methods and apparatus to perform audio watermarking and watermark detection and extraction |
US8666528B2 (en) | 2009-05-01 | 2014-03-04 | The Nielsen Company (Us), Llc | Methods, apparatus and articles of manufacture to provide secondary content in association with primary broadcast media content |
US10074147B2 (en) | 2010-06-16 | 2018-09-11 | Parexel International Corporation | Integrated clinical trial workflow system |
TW201309698A (zh) | 2011-03-18 | 2013-03-01 | Ono Pharmaceutical Co | 四氫咔啉衍生物 |
EP3099689B1 (en) * | 2014-01-30 | 2022-01-26 | Council of Scientific and Industrial Research | Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof |
DE102014114021A1 (de) | 2014-09-26 | 2016-03-31 | Obrist Technologies Gmbh | Batteriegehäuse |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
WO2022022669A1 (en) * | 2020-07-30 | 2022-02-03 | Biofront Therapeutics (Beijing) Co., Ltd. | Dual-functional compounds and methods of use |
TWI810622B (zh) * | 2020-07-30 | 2023-08-01 | 大陸商百放英庫醫藥科技(北京)有限公司 | 雙功能化合物及其使用方法 |
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Cited By (5)
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JP2013518851A (ja) * | 2010-02-05 | 2013-05-23 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | sGC刺激剤又はsGC活性化剤単独及びPDE5阻害剤と組合せた嚢胞性線維症処置 |
JP2016155857A (ja) * | 2010-02-05 | 2016-09-01 | アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 嚢胞性線維症処置用のsGC刺激剤又はsGC活性化剤単独及びPDE5阻害剤との組み合わせ物 |
JP2020520945A (ja) * | 2017-05-22 | 2020-07-16 | トパドゥール ファーマ アーゲー | 新規二重作用モード可溶性グアニル酸シクラーゼ活性化因子およびホスホジエステラーゼ阻害剤ならびにその使用 |
JP7182568B2 (ja) | 2017-05-22 | 2022-12-02 | トパドゥール ファーマ アーゲー | 新規二重作用モード可溶性グアニル酸シクラーゼ活性化因子およびホスホジエステラーゼ阻害剤ならびにその使用 |
US11905293B2 (en) | 2017-05-22 | 2024-02-20 | Topadur Pharma Ag | Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof |
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US6177428B1 (en) | 2001-01-23 |
US6197778B1 (en) | 2001-03-06 |
US5958926A (en) | 1999-09-28 |
AU6133499A (en) | 2000-03-21 |
US6133272A (en) | 2000-10-17 |
CA2339189A1 (en) | 2000-03-09 |
US6221881B1 (en) | 2001-04-24 |
EP1109543A1 (en) | 2001-06-27 |
US6211179B1 (en) | 2001-04-03 |
EP1109543A4 (en) | 2006-03-08 |
US6172060B1 (en) | 2001-01-09 |
AU773269B2 (en) | 2004-05-20 |
US6172068B1 (en) | 2001-01-09 |
WO2000012076A9 (en) | 2000-08-17 |
US6197782B1 (en) | 2001-03-06 |
US6316457B1 (en) | 2001-11-13 |
US6232321B1 (en) | 2001-05-15 |
WO2000012076A1 (en) | 2000-03-09 |
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