JP2002521045A - Ｋｖｌｑｔ１−ｑｔ延長症候群 - Google Patents

Ｋｖｌｑｔ１−ｑｔ延長症候群

Info

Publication number
JP2002521045A
JP2002521045A JP2000562052A JP2000562052A JP2002521045A JP 2002521045 A JP2002521045 A JP 2002521045A JP 2000562052 A JP2000562052 A JP 2000562052A JP 2000562052 A JP2000562052 A JP 2000562052A JP 2002521045 A JP2002521045 A JP 2002521045A
Authority
JP
Japan
Prior art keywords
kvlqt1
seq
base
kcne1
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000562052A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002521045A5 (enExample
Inventor
マーク・ティ・キィーティング
マイケル・シー・サングイネッティ
マーク・イー・カラン
グレゴリー・エム・ランズ
ティモシー・ディ・コナーズ
ティモシー・シー・バーン
イゴア・スプラウスキ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of JP2002521045A publication Critical patent/JP2002521045A/ja
Publication of JP2002521045A5 publication Critical patent/JP2002521045A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2000562052A 1998-07-29 1999-05-12 Ｋｖｌｑｔ１−ｑｔ延長症候群 Pending JP2002521045A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9447798P 1998-07-29 1998-07-29
US60/094,477 1998-07-29
US09/135,010 1998-08-17
US09/135,010 US6277978B1 (en) 1995-12-22 1998-08-17 KVLQT1—a long QT syndrome gene
PCT/US1999/010260 WO2000006199A1 (en) 1998-07-29 1999-05-12 Kvlqt1 - a long qt syndrome gene

Publications (2)

Publication Number Publication Date
JP2002521045A true JP2002521045A (ja) 2002-07-16
JP2002521045A5 JP2002521045A5 (enExample) 2006-07-13

Family

ID=26788931

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000562052A Pending JP2002521045A (ja) 1998-07-29 1999-05-12 Ｋｖｌｑｔ１−ｑｔ延長症候群

Country Status (8)

Country Link
US (5) US6277978B1 (enExample)
EP (1) EP1100538B1 (enExample)
JP (1) JP2002521045A (enExample)
AT (1) ATE369420T1 (enExample)
AU (1) AU758048B2 (enExample)
CA (1) CA2336263A1 (enExample)
DE (1) DE69936781T2 (enExample)
WO (1) WO2000006199A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797486B2 (en) * 1996-09-11 2004-09-28 Icagen, Incorporated Small and intermediate conductance, calcium-activated potassium channels and uses thereof
US7179597B2 (en) 2000-04-13 2007-02-20 Georgetown University Genetic diagnosis for QT prolongation related adverse drug reactions
US6348486B1 (en) * 2000-10-17 2002-02-19 American Home Products Corporation Methods for modulating bladder function
CA2457365A1 (en) * 2001-08-20 2003-02-27 Genaissance Pharmaceuticals, Inc. Polymorphisms associated with ion-channel disease
JP2006511218A (ja) * 2002-12-21 2006-04-06 ファイザー・プロダクツ・インク 薬物誘発性不整脈に関連する方法および組成物
US7537928B2 (en) * 2003-08-22 2009-05-26 Masonic Medical Research Laboratory Mutations in ion channel proteins associated with sudden cardiac death
US7833718B2 (en) * 2006-11-06 2010-11-16 Masonic Medical Research Laboratory CACNA1C nucleic acid mutations as indicators of shorter than normal QT interval and ST segment elevation associated with sudden cardiac death

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2085478A1 (en) * 1995-12-22 2009-08-05 University Of Utah Research Foundation A long QT syndrome gene which encodes KVLQT1 and its association with minK
ATE211918T1 (de) 1996-10-21 2002-02-15 Morten Sloth Weidner Pharmazeutische zusammenstellungen mit parthenium integrifolium oder mit einem extrakt oder einer komponente davon, verwendung dieses pflanzenmaterials zur herstellung von medizin und ein verfahren zur extraktherstellung von parthenium integrifolium
DK1066042T3 (da) 1998-03-26 2006-12-18 Phytopharm Plc Steroidale saponiner til behandling af Alzheimers sygdom
AUPP797598A0 (en) 1998-12-30 1999-01-28 Butters, Desley Therapeutic agent
US6194469B1 (en) 1998-12-11 2001-02-27 Board Of Trustees Operating Michigan State Univeristy Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids
US20010006686A1 (en) 1999-03-19 2001-07-05 David G. Corley Inflammatory mediation obtained from atractylodes lancea

Also Published As

Publication number Publication date
US20030170708A1 (en) 2003-09-11
US6451534B1 (en) 2002-09-17
AU3980099A (en) 2000-02-21
WO2000006199A8 (en) 2001-04-12
US6972176B2 (en) 2005-12-06
DE69936781D1 (de) 2007-09-20
US6582913B1 (en) 2003-06-24
AU758048B2 (en) 2003-03-13
CA2336263A1 (en) 2000-02-10
ATE369420T1 (de) 2007-08-15
DE69936781T2 (de) 2008-06-05
EP1100538B1 (en) 2007-08-08
US6277978B1 (en) 2001-08-21
EP1100538A2 (en) 2001-05-23
EP1100538A4 (en) 2003-07-02
US6420124B1 (en) 2002-07-16
WO2000006199A1 (en) 2000-02-10

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CA2416545C (en) Common polymorphism in scn5a implicated in drug-induced cardiac arrhythmia
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