ATE369420T1 - Kvlqt1 - im zusammenhang mit 'long qt syndrom' - Google Patents

Kvlqt1 - im zusammenhang mit 'long qt syndrom'

Info

Publication number
ATE369420T1
ATE369420T1 AT99922910T AT99922910T ATE369420T1 AT E369420 T1 ATE369420 T1 AT E369420T1 AT 99922910 T AT99922910 T AT 99922910T AT 99922910 T AT99922910 T AT 99922910T AT E369420 T1 ATE369420 T1 AT E369420T1
Authority
AT
Austria
Prior art keywords
syndrome
long
kvlqt1
disclosed
mutations
Prior art date
Application number
AT99922910T
Other languages
German (de)
English (en)
Inventor
Mark T Keating
Michael C Sanguinetti
Mark E Curran
Gregory M Landes
Timothy D Connors
Timothy C Burn
Igor Splawski
Qing Cn Wang
Original Assignee
Univ Utah Res Found
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found, Genzyme Corp filed Critical Univ Utah Res Found
Application granted granted Critical
Publication of ATE369420T1 publication Critical patent/ATE369420T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99922910T 1998-07-29 1999-05-12 Kvlqt1 - im zusammenhang mit 'long qt syndrom' ATE369420T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9447798P 1998-07-29 1998-07-29
US09/135,010 US6277978B1 (en) 1995-12-22 1998-08-17 KVLQT1—a long QT syndrome gene

Publications (1)

Publication Number Publication Date
ATE369420T1 true ATE369420T1 (de) 2007-08-15

Family

ID=26788931

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99922910T ATE369420T1 (de) 1998-07-29 1999-05-12 Kvlqt1 - im zusammenhang mit 'long qt syndrom'

Country Status (8)

Country Link
US (5) US6277978B1 (enExample)
EP (1) EP1100538B1 (enExample)
JP (1) JP2002521045A (enExample)
AT (1) ATE369420T1 (enExample)
AU (1) AU758048B2 (enExample)
CA (1) CA2336263A1 (enExample)
DE (1) DE69936781T2 (enExample)
WO (1) WO2000006199A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4052525B2 (ja) * 1996-09-11 2008-02-27 オレゴン ヘルス サイエンシーズ ユニバーシティー 低及び中間コンダクタンスのカルシウム活性化されたカリウムチャネル及びその使用
DE60131970T2 (de) * 2000-04-13 2008-12-11 Georgetown University Genetische diagnose zur feststellung von qt-verlängerungen als unerwünschte reaktion auf arzneimittel
TWI287984B (en) * 2000-10-17 2007-10-11 Wyeth Corp Pharmaceutical composition for modulating bladder function
CA2457365A1 (en) * 2001-08-20 2003-02-27 Genaissance Pharmaceuticals, Inc. Polymorphisms associated with ion-channel disease
JP2006511218A (ja) * 2002-12-21 2006-04-06 ファイザー・プロダクツ・インク 薬物誘発性不整脈に関連する方法および組成物
US7537928B2 (en) * 2003-08-22 2009-05-26 Masonic Medical Research Laboratory Mutations in ion channel proteins associated with sudden cardiac death
US7833718B2 (en) * 2006-11-06 2010-11-16 Masonic Medical Research Laboratory CACNA1C nucleic acid mutations as indicators of shorter than normal QT interval and ST segment elevation associated with sudden cardiac death

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0870041B1 (en) * 1995-12-22 2007-01-24 The University of Utah Research Foundation KVLQT1 - A LONG QT SYNDROME GENE WHICH ENCODES KVLQT1 WHICH COASSEMBLES WITH minK TO FORM CARDIAC Iks POTASSIUM CHANNELS
PT1007067E (pt) 1996-10-21 2002-07-31 Eurovita A S Composicoes farmaceuticas contendo partenio integrifolium ou partes dele ou um seu extracto ou componente o uso desse material vegetal para a preparacao de certos medicamentos e um processo para preparar um extracto de partenio integrifolium
HUP0101693A3 (en) 1998-03-26 2002-08-28 Phytopharm Plc Godmanchester Use of steroidal sapogenins and their derivatives for producing pharmaceutical compositions for the treatment of alzheimeirs disease
AUPP797598A0 (en) 1998-12-30 1999-01-28 Butters, Desley Therapeutic agent
US6194469B1 (en) 1998-12-11 2001-02-27 Board Of Trustees Operating Michigan State Univeristy Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids
US20010006686A1 (en) 1999-03-19 2001-07-05 David G. Corley Inflammatory mediation obtained from atractylodes lancea

Also Published As

Publication number Publication date
CA2336263A1 (en) 2000-02-10
US6582913B1 (en) 2003-06-24
WO2000006199A1 (en) 2000-02-10
US6277978B1 (en) 2001-08-21
EP1100538A2 (en) 2001-05-23
EP1100538B1 (en) 2007-08-08
US20030170708A1 (en) 2003-09-11
AU3980099A (en) 2000-02-21
DE69936781D1 (de) 2007-09-20
DE69936781T2 (de) 2008-06-05
US6420124B1 (en) 2002-07-16
WO2000006199A8 (en) 2001-04-12
AU758048B2 (en) 2003-03-13
EP1100538A4 (en) 2003-07-02
US6451534B1 (en) 2002-09-17
JP2002521045A (ja) 2002-07-16
US6972176B2 (en) 2005-12-06

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