JP2002520286A5 - - Google Patents
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- Publication number
- JP2002520286A5 JP2002520286A5 JP2000558822A JP2000558822A JP2002520286A5 JP 2002520286 A5 JP2002520286 A5 JP 2002520286A5 JP 2000558822 A JP2000558822 A JP 2000558822A JP 2000558822 A JP2000558822 A JP 2000558822A JP 2002520286 A5 JP2002520286 A5 JP 2002520286A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- formula
- caffeine
- compound
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 20
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 10
- 229960001948 caffeine Drugs 0.000 description 10
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 10
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
- 229960002870 gabapentin Drugs 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 description 3
- 229960001233 pregabalin Drugs 0.000 description 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9213198P | 1998-07-09 | 1998-07-09 | |
| US60/092,131 | 1998-07-09 | ||
| PCT/US1999/013670 WO2000002562A1 (en) | 1998-07-09 | 1999-06-18 | Compositions comprising gaba analogs and caffeine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520286A JP2002520286A (ja) | 2002-07-09 |
| JP2002520286A5 true JP2002520286A5 (US07794700-20100914-C00152.png) | 2006-08-10 |
Family
ID=22231777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000558822A Withdrawn JP2002520286A (ja) | 1998-07-09 | 1999-06-18 | Ｇａｂａ類縁体及びカフェインを含んでなる組成物 |
Country Status (13)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003167A1 (en) | 1996-07-24 | 1998-01-29 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
| US6992109B1 (en) * | 1999-04-08 | 2006-01-31 | Segal Catherine A | Method for the treatment of incontinence |
| DK1169060T3 (da) * | 1999-04-09 | 2006-01-16 | Euro Celtique Sa | Natriumkanalblokkerpræparater og anvendelse deraf |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| MXPA04002009A (es) | 2001-09-03 | 2004-07-08 | Newron Pharm Spa | Composicion farmaceutica que comprende gabapentina o un analogo de la misma y alfa-aminoamida y su uso como analgesico. |
| ATE371496T1 (de) * | 2004-03-12 | 2007-09-15 | Warner Lambert Co | C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin |
| JP2007530657A (ja) * | 2004-04-01 | 2007-11-01 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | Ｐキラル性ホスホランの調製および不斉合成でのその使用 |
| DE602005018965D1 (de) * | 2004-06-21 | 2010-03-04 | Warner Lambert Co | Herstellung von pregabalin und verwandten verbindungen |
| KR101277520B1 (ko) * | 2004-09-10 | 2013-06-21 | 뉴론 파마슈티칼즈 에스. 피. 에이. | （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물 |
| ES2556937T3 (es) | 2005-12-22 | 2016-01-21 | Newron Pharmaceuticals S.P.A. | Derivados de 2-feniletilamino como moduladores de los canales de calcio y/o sodio |
| US7645767B2 (en) * | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| CH699327B1 (de) | 2007-02-14 | 2010-03-15 | Oerlikon Heberlein Temco Wattw | Vorrichtung zum gleichzeitigen Behandeln von mehreren multifilen Fäden. |
| US10300031B2 (en) | 2007-08-06 | 2019-05-28 | Trinity Laboratories Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| JP2010043063A (ja) * | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| US20100190752A1 (en) * | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
| WO2011141923A2 (en) | 2010-05-14 | 2011-11-17 | Lupin Limited | Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin |
| WO2012059797A1 (en) | 2010-11-04 | 2012-05-10 | Lupin Limited | Process for synthesis of (s) - pregabalin |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4656177A (en) | 1982-07-22 | 1987-04-07 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US5248678A (en) * | 1992-06-30 | 1993-09-28 | Fractal Laboratories, Inc. | Methods for increasing arousal and alertness and for the amelioration of comatose states |
| AU7604194A (en) | 1993-09-07 | 1995-03-27 | Procter & Gamble Company, The | Compositions containing an amino acid salt of propionic acid non-steroidal anti-inflammatory agents and caffeine |
| US5443838A (en) | 1993-09-15 | 1995-08-22 | Koenig, Jr.; Steven M. | Nutritional supplementation system |
| ES2167717T3 (es) | 1996-03-14 | 2002-05-16 | Warner Lambert Co | Nuevos aminoacidos ciclicos sustituidos como agentes farmaceuticos. |
| AU4078897A (en) * | 1996-08-23 | 1998-03-06 | Algos Pharmaceutical Corporation | Anticonvulsant containing composition for treating neuropathic pain |
| ATE361909T1 (de) * | 1996-10-23 | 2007-06-15 | Warner Lambert Co | Substituierte gamma-aminobuttersäurederivate als arzneimittel |
| ATE311867T1 (de) * | 1997-09-08 | 2005-12-15 | Warner Lambert Co | Analgetische zusammensetzung enthaltend antiepileptische arzneistoffe und deren verwendungen |
-
1999
- 1999-06-18 NZ NZ508490A patent/NZ508490A/en unknown
- 1999-06-18 WO PCT/US1999/013670 patent/WO2000002562A1/en not_active Application Discontinuation
- 1999-06-18 PL PL99345340A patent/PL345340A1/xx not_active Application Discontinuation
- 1999-06-18 ID IDW20010054A patent/ID28277A/id unknown
- 1999-06-18 US US09/743,371 patent/US6326374B1/en not_active Expired - Fee Related
- 1999-06-18 KR KR1020017000260A patent/KR20010071777A/ko not_active Application Discontinuation
- 1999-06-18 JP JP2000558822A patent/JP2002520286A/ja not_active Withdrawn
- 1999-06-18 CA CA002332915A patent/CA2332915C/en not_active Expired - Fee Related
- 1999-06-18 EP EP99930357A patent/EP1094817A1/en not_active Ceased
- 1999-06-18 AU AU46910/99A patent/AU772156B2/en not_active Ceased
- 1999-06-18 BR BR9911917-0A patent/BR9911917A/pt not_active Application Discontinuation
-
2000
- 2000-12-04 ZA ZA200007168A patent/ZA200007168B/en unknown
-
2001
- 2001-01-08 NO NO20010119A patent/NO20010119L/no unknown
