JP2002519425A5 - - Google Patents
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- JP2002519425A5 JP2002519425A5 JP2000558102A JP2000558102A JP2002519425A5 JP 2002519425 A5 JP2002519425 A5 JP 2002519425A5 JP 2000558102 A JP2000558102 A JP 2000558102A JP 2000558102 A JP2000558102 A JP 2000558102A JP 2002519425 A5 JP2002519425 A5 JP 2002519425A5
- Authority
- JP
- Japan
- Prior art keywords
- carbons
- halide
- conr
- patient
- nhcor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000004820 halides Chemical class 0.000 description 12
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000000753 cycloalkyl group Chemical group 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000030951 Phosphotransferases Human genes 0.000 description 2
- 108091000081 Phosphotransferases Proteins 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/109,131 US6013646A (en) | 1998-07-02 | 1998-07-02 | Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
| US09/109,131 | 1998-07-02 | ||
| PCT/EP1999/004369 WO2000001699A1 (en) | 1998-07-02 | 1999-06-23 | Novel indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002519425A JP2002519425A (ja) | 2002-07-02 |
| JP2002519425A5 true JP2002519425A5 (US07794700-20100914-C00152.png) | 2006-08-10 |
Family
ID=22325955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000558102A Pending JP2002519425A (ja) | 1998-07-02 | 1999-06-23 | 神経変性疾患および癌の処置に有用な新規なインドロカルバゾール誘導体 |
Country Status (6)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6013646A (en) | 1998-07-02 | 2000-01-11 | Bayer Corporation | Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
| US6660750B2 (en) | 2000-02-15 | 2003-12-09 | University Of Iowa Research Foundation | Flavopiridol methods and compositions for HIV therapy |
| WO2001064199A2 (en) * | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with taxane compounds |
| WO2001085151A2 (en) * | 2000-05-08 | 2001-11-15 | Psoriasis Research Institute | Chimeric animal model and treatment of psoriasis |
| US7129250B2 (en) * | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| JP2005511719A (ja) * | 2001-12-13 | 2005-04-28 | ファーマサイクリクス，インコーポレイテッド | 神経性進行に影響を与えるためのプロセス |
| DE10161940A1 (de) * | 2001-12-17 | 2003-07-03 | Nad Ag | N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren |
| CA2477604A1 (en) * | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| DE10255343B4 (de) * | 2002-11-27 | 2006-09-07 | Nad Ag | N,N-Verbrückte, Stickstoff-Substituierte Carbacyclische Indolocarbazole als Proteinkinase-Inhibitoren |
| EP1737472B1 (en) | 2004-03-29 | 2014-08-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine |
| US20100028339A1 (en) * | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| US20110008327A1 (en) * | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
| US20060058250A1 (en) * | 2004-09-10 | 2006-03-16 | Cephalon, Inc. | Methods of treating proliferative skin diseases using carbazole derivatives |
| EP1843734A4 (en) * | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | COMPOSITIONS AND METHOD FOR INTENSIFYING COGNITIVE FUNCTIONS |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| WO2006118630A2 (en) * | 2005-05-02 | 2006-11-09 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of alzheimer's disease |
| US20070249590A1 (en) * | 2005-10-28 | 2007-10-25 | Wilson Lawrence J | Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders |
| CN1870631B (zh) * | 2005-11-11 | 2010-04-14 | 华为技术有限公司 | 媒体网关的门控方法 |
| CA2672650C (en) * | 2006-12-14 | 2015-09-08 | Tautatis, Inc. | Compositions and methods for the treatment of cancer |
| US20100273769A1 (en) * | 2009-01-26 | 2010-10-28 | Hanno Roder | Composition and method for the treatment of parkinson's disease |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968690A (en) * | 1986-05-27 | 1990-11-06 | United States Government As Represented By The Secretary Of The Dept. Of Health And Human Services | 3-deazaneplanocin, intermediates for it, and antiviral composition and method of treatment using it |
| EP0303697B1 (en) * | 1987-03-09 | 1997-10-01 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance k-252 |
| JPH07113027B2 (ja) * | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
| US5618809A (en) * | 1989-12-14 | 1997-04-08 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 |
| US5189046A (en) * | 1990-08-14 | 1993-02-23 | Nova Pharmaceutical Corporation | Protein kinase C modulators |
| JPH04187686A (ja) * | 1990-11-20 | 1992-07-06 | Meiji Seika Kaisha Ltd | インドロカルバゾール誘導体 |
| EP1026237B1 (en) * | 1991-08-09 | 2004-03-24 | Massachusetts Institute Of Technology | Use of an inhibitor of Tau/neurofilament protein kinase PK40 |
| US5955444A (en) | 1991-08-09 | 1999-09-21 | Massachusetts Institute Of Technology | Method of inhibiting abnormal tau hyper phosphorylation in a cell |
| NZ245203A (en) * | 1991-11-29 | 1997-07-27 | Banyu Pharma Co Ltd | 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates |
| US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| EP0575955B1 (en) * | 1992-06-22 | 1999-09-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing staurosporine derivatives |
| US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| CA2140653A1 (en) * | 1992-08-12 | 1994-03-03 | Irene Abraham | Protein kinase inhibitors and related compounds combined with taxol |
| EP0643966A4 (en) * | 1993-03-03 | 1995-08-09 | Kyowa Hakko Kogyo Kk | SENSITIVITY BOOSTER FOR ANTINEOPLASTIC AGENT. |
| US5516771A (en) * | 1993-05-28 | 1996-05-14 | Cephalon, Inc. | Use of indolocarbazole derivatives to treat a pathological condition of the prostate |
| US5468872A (en) * | 1993-09-16 | 1995-11-21 | Cephalon, Inc. | K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| EP1449529B1 (en) * | 1993-12-23 | 2010-01-27 | Eli Lilly And Company | Protein Kinase C Inhibitors |
| US5654307A (en) * | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| WO1995022331A1 (en) * | 1994-02-18 | 1995-08-24 | Cephalon, Inc. | Aqueous indolocarbazole solutions |
| US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5594009A (en) * | 1994-10-14 | 1997-01-14 | Cephalon, Inc. | Fused pyrrolocarbazoles |
| US5648378A (en) * | 1995-06-07 | 1997-07-15 | Research Corporation Technologies, Inc. | 2-iminochromene derivatives as inhibitors of protein tyrosine kinase |
| US6013646A (en) | 1998-07-02 | 2000-01-11 | Bayer Corporation | Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
-
1998
- 1998-07-02 US US09/109,131 patent/US6013646A/en not_active Expired - Fee Related
-
1999
- 1999-06-23 WO PCT/EP1999/004369 patent/WO2000001699A1/en not_active Application Discontinuation
- 1999-06-23 CA CA002336419A patent/CA2336419A1/en not_active Abandoned
- 1999-06-23 AU AU47766/99A patent/AU754399B2/en not_active Ceased
- 1999-06-23 JP JP2000558102A patent/JP2002519425A/ja active Pending
- 1999-06-23 EP EP99931158A patent/EP1091962A1/en not_active Withdrawn
- 1999-08-25 US US09/382,539 patent/US6541468B1/en not_active Expired - Fee Related
