JP2002515500A5 - - Google Patents

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Publication number
JP2002515500A5
JP2002515500A5 JP2000549611A JP2000549611A JP2002515500A5 JP 2002515500 A5 JP2002515500 A5 JP 2002515500A5 JP 2000549611 A JP2000549611 A JP 2000549611A JP 2000549611 A JP2000549611 A JP 2000549611A JP 2002515500 A5 JP2002515500 A5 JP 2002515500A5
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JP
Japan
Prior art keywords
alkyl
residue
aryl
heteroaryl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000549611A
Other languages
English (en)
Japanese (ja)
Other versions
JP4503176B2 (ja
JP2002515500A (ja
Filing date
Publication date
Priority claimed from EP98109077A external-priority patent/EP0960882A1/en
Application filed filed Critical
Publication of JP2002515500A publication Critical patent/JP2002515500A/ja
Publication of JP2002515500A5 publication Critical patent/JP2002515500A5/ja
Application granted granted Critical
Publication of JP4503176B2 publication Critical patent/JP4503176B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2000549611A 1998-05-19 1999-05-05 骨吸収防止剤及びビトロネクチン受容体拮抗薬としての新規のチエニル置換アシルグアニジン Expired - Lifetime JP4503176B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98109077.2 1998-05-19
EP98109077A EP0960882A1 (en) 1998-05-19 1998-05-19 Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
PCT/EP1999/003064 WO1999059992A1 (en) 1998-05-19 1999-05-05 Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists

Publications (3)

Publication Number Publication Date
JP2002515500A JP2002515500A (ja) 2002-05-28
JP2002515500A5 true JP2002515500A5 (https=) 2006-04-20
JP4503176B2 JP4503176B2 (ja) 2010-07-14

Family

ID=8231959

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000549611A Expired - Lifetime JP4503176B2 (ja) 1998-05-19 1999-05-05 骨吸収防止剤及びビトロネクチン受容体拮抗薬としての新規のチエニル置換アシルグアニジン

Country Status (9)

Country Link
US (2) US6566366B1 (https=)
EP (2) EP0960882A1 (https=)
JP (1) JP4503176B2 (https=)
AR (1) AR018358A1 (https=)
AT (1) ATE322490T1 (https=)
AU (1) AU4138599A (https=)
DE (1) DE69930740T2 (https=)
TW (2) TW546294B (https=)
WO (1) WO1999059992A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405149B1 (en) 1998-12-21 2008-07-29 Megica Corporation Post passivation method for semiconductor chip or wafer
US7381642B2 (en) 2004-09-23 2008-06-03 Megica Corporation Top layers of metal for integrated circuits
US6965165B2 (en) 1998-12-21 2005-11-15 Mou-Shiung Lin Top layers of metal for high performance IC's
WO2000075129A1 (en) * 1999-06-07 2000-12-14 Shire Biochem Inc. Thiophene integrin inhibitors
EP1108721A1 (en) 1999-12-15 2001-06-20 Aventis Pharma Deutschland GmbH Thienylalanine derivatives as inhibitors of cell adhesion
FR2806082B1 (fr) * 2000-03-07 2002-05-17 Adir Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE10041428A1 (de) * 2000-08-23 2002-03-07 Merck Patent Gmbh Biphenylderivate
DE10061876A1 (de) * 2000-12-12 2002-06-20 Aventis Pharma Gmbh Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
CN101624391A (zh) * 2001-06-11 2010-01-13 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
US7402608B2 (en) * 2002-12-10 2008-07-22 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of Flavivirus infections
US7098241B2 (en) * 2002-12-16 2006-08-29 Hoffmann-La Roche Inc. Thiophene hydroxamic acid derivatives
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
GB0412553D0 (en) * 2004-06-04 2004-07-07 Univ Aberdeen Therapeutic agents for the treatment of bone conditions
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
BRPI0610283A2 (pt) * 2005-05-13 2010-10-19 Virochem Pharma Inc composto, uso do mesmo na preparação de um medicamento para o tratamento ou prevenção de uma infecção por vìrus de hepatite c, composição farmacêutica e combinação farmacêutica
CA2670260A1 (en) 2006-11-15 2008-05-22 Virochem Pharma Inc. Thiophene analogues for the treatment or prevention of flavivirus infections
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
JPWO2015137408A1 (ja) * 2014-03-11 2017-04-06 Ｅａファーマ株式会社 ヘテロアリールカルボン酸エステル誘導体の製造方法及びその製造中間体
SG11201609050UA (en) 2014-05-30 2016-12-29 Pfizer Carbonitrile derivatives as selective androgen receptor modulators
SI3262028T1 (sl) 2014-12-17 2022-02-28 Pimco 2664 Limited N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamidne in N-(-4hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamidne spojine in njihova terapevtska uporaba
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5125050A (en) * 1991-05-03 1992-06-23 Bell Communications Research, Inc. Vertical metallically loaded polarization splitter and polarization-diversified optical receiver
US5204350A (en) * 1991-08-09 1993-04-20 Merck & Co., Inc. Method of inhibiting osteoclast-mediated bone resorption by administration of n-heterocyclicalkyl-substituted phenyl derivatives
AU674553B2 (en) * 1992-10-14 1997-01-02 Merck & Co., Inc. Fibrinogen receptor antagonists
JPH10501222A (ja) * 1994-05-27 1998-02-03 メルク エンド カンパニー インコーポレーテッド 破骨細胞仲介骨吸収を抑制するための化合物
FR2742752B1 (fr) * 1995-12-21 1998-01-30 Adir Nouveaux composes du thiophene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19629816A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten

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