JP2002512533A5 - - Google Patents

Download PDF

Info

Publication number
JP2002512533A5
JP2002512533A5 JP1999555528A JP55552899A JP2002512533A5 JP 2002512533 A5 JP2002512533 A5 JP 2002512533A5 JP 1999555528 A JP1999555528 A JP 1999555528A JP 55552899 A JP55552899 A JP 55552899A JP 2002512533 A5 JP2002512533 A5 JP 2002512533A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1999555528A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002512533A (ja
Filing date
Publication date
Priority claimed from US09/071,739 external-priority patent/US6177545B1/en
Application filed filed Critical
Publication of JP2002512533A publication Critical patent/JP2002512533A/ja
Publication of JP2002512533A5 publication Critical patent/JP2002512533A5/ja
Pending legal-status Critical Current

Links

JP55552899A 1998-05-01 1999-04-29 ヘパラナーゼ特異分子プローブならびにその研究および医学応用用途 Pending JP2002512533A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/071,739 US6177545B1 (en) 1997-09-02 1998-05-01 Heparanase specific molecular probes and their use in research and medical applications
US09/071,739 1998-05-01
PCT/US1999/009255 WO1999057153A1 (en) 1998-05-01 1999-04-29 Heparanase specific molecular probes and their use in research and medical applications

Publications (2)

Publication Number Publication Date
JP2002512533A JP2002512533A (ja) 2002-04-23
JP2002512533A5 true JP2002512533A5 (cg-RX-API-DMAC10.html) 2006-09-21

Family

ID=22103268

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55552899A Pending JP2002512533A (ja) 1998-05-01 1999-04-29 ヘパラナーゼ特異分子プローブならびにその研究および医学応用用途

Country Status (11)

Country Link
US (6) US6177545B1 (cg-RX-API-DMAC10.html)
EP (2) EP1073682B1 (cg-RX-API-DMAC10.html)
JP (1) JP2002512533A (cg-RX-API-DMAC10.html)
AT (1) ATE328008T1 (cg-RX-API-DMAC10.html)
AU (1) AU754228B2 (cg-RX-API-DMAC10.html)
CA (1) CA2295323A1 (cg-RX-API-DMAC10.html)
DE (1) DE69931624T2 (cg-RX-API-DMAC10.html)
ES (1) ES2267266T3 (cg-RX-API-DMAC10.html)
IL (1) IL133265A0 (cg-RX-API-DMAC10.html)
NO (1) NO996229L (cg-RX-API-DMAC10.html)
WO (1) WO1999057153A1 (cg-RX-API-DMAC10.html)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699672B1 (en) * 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US5968822A (en) * 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US20030161823A1 (en) * 1998-08-31 2003-08-28 Neta Ilan Therapeutic and cosmetic uses of heparanases
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US6562950B2 (en) * 1997-09-02 2003-05-13 Insight Strategy & Marketing Ltd. Heparanase activity neutralizing anti-heparanase monoclonal antibody
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
AU2878600A (en) * 1999-03-01 2000-09-21 Hadasit Medical Research Services & Development Company Ltd Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
CA2377498A1 (en) * 1999-06-25 2001-01-04 Insight Strategy & Marketing Ltd. Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase
US20040161745A1 (en) * 1999-12-23 2004-08-19 Gerhard Siemeister Human heparanase-related polypeptide and nucleic acid
AU2001294563A1 (en) 2000-09-15 2002-03-26 Reddy Us Therapeutics, Inc Methods and compositions for glycosidase assays
WO2002050243A2 (en) * 2000-12-19 2002-06-27 Insight Strategy And Marketing Ltd. The use of ecm degrading enzymes for the improvement of cell transplantation
WO2002090574A1 (en) * 2001-05-09 2002-11-14 Insight Biopharmaceuticals Ltd. Methods and kits utilizing heparanase as a diagnostic marker for haemostatic disorders
WO2003006645A2 (en) * 2001-07-13 2003-01-23 Imclone Systems Incorporated Method and composition for inhibiting heparanase activity
US20030036103A1 (en) * 2001-07-31 2003-02-20 Sivaram Pillarisetti Methods and compositions for diagnosis and treatment of vascular conditions
US6671189B2 (en) * 2001-11-09 2003-12-30 Minebea Co., Ltd. Power converter having primary and secondary side switches
EP1382574A3 (en) * 2002-06-21 2004-05-26 Sanden Corporation Mineral water making apparatus
WO2004043989A2 (en) * 2002-11-07 2004-05-27 Medarex, Inc. Human monoclonal antibodies to heparanase
WO2004058959A1 (ja) * 2002-12-26 2004-07-15 Nippon Shinyaku Co., Ltd. PNPaseの製造法
WO2004108065A2 (en) * 2003-06-09 2004-12-16 Insight Biopharmaceuticals Ltd. Heparanase activity neutralizing anti- heparanase monoclonal antibody and other anti-heparanase antibodies
ITMI20031714A1 (it) 2003-09-05 2005-03-06 Gentium Spa Formazioni ad azione antitumorale.
HUE025328T2 (en) * 2003-12-10 2016-03-29 Squibb & Sons Llc IP-10 antibodies and their use
IL162276A0 (en) * 2004-06-01 2005-11-20 Hadasit Med Res Service Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
WO2006099126A2 (en) * 2005-03-11 2006-09-21 Ciphergen Biosystems, Inc. Biomarkers for ovarian cancer and endometrial cancer: hepcidin
EP1982722A1 (en) * 2007-04-16 2008-10-22 Gentium S.p.A. Use of oligotide for the treatment of renal diseases
US20100248260A1 (en) * 2007-12-05 2010-09-30 Massachusetts Institute Of Technology Glycosaminoglycan-coated particles and uses thereof
KR101578342B1 (ko) * 2008-03-31 2015-12-16 가부시키가이샤 시세이도 주름을 방지 또는 개선하기 위한 경구, 주사, 피부 외용제 및 미용 방법
EP2328944B1 (en) * 2008-09-16 2018-01-24 Dow Global Technologies LLC Polymeric compositions and foams, methods of making the same, and articles prepared from the same
EP2507265B1 (en) * 2009-12-01 2016-05-11 Compugen Ltd. Antibody specific for heparanase splice variant T5 and its use.
CN107007617A (zh) 2010-11-12 2017-08-04 真蒂奥姆责任有限公司 去纤维蛋白多核苷酸用于预防和/或治疗移植物抗宿主病(gvhd)
SG11201408481UA (en) 2012-06-22 2015-01-29 Gentium Spa Euglobulin-based method for determining the biological activity of defibrotide
US9943545B2 (en) * 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
WO2017064716A1 (en) 2015-10-13 2017-04-20 Rappaport Family Institute For Research Heparanase-neutralizing monoclonal antibodies
US10349968B2 (en) * 2016-05-02 2019-07-16 Covidien Lp Devices, systems, and methods for establishing electrical and fluid connections to surgical instruments

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US931129A (en) * 1904-03-30 1909-08-17 Henry La Casse Shaft-hanger.
US2295323A (en) * 1940-08-02 1942-09-08 Edwin H Armstrong Current limiting device
US4117841A (en) * 1977-02-07 1978-10-03 Anthony Perrotta Medicated bandage pocket
US4659581A (en) * 1981-09-16 1987-04-21 Takeda Chemical Industries, Ltd. Method of producing granular chemical seasoning of high specific volume and product
US4455296A (en) * 1982-02-02 1984-06-19 Board Of Regents, The University Of Texas System Hybrid cell lines producing monoclonal antibodies directed against Haemophilus influenzae
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4859581A (en) * 1986-03-10 1989-08-22 Board Of Regents, The University Of Texas System Endoglycosidase assay
IL79255A0 (en) * 1986-06-26 1986-09-30 Hadassah Med Org Composition for metastasis prevention
US5206223A (en) * 1986-06-26 1993-04-27 Yeda Research And Development Co. Ltd. Method for inhibiting heparanase activity
DK173067B1 (da) * 1986-06-27 1999-12-13 Univ Washington Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa
AU7852687A (en) * 1986-08-21 1988-03-08 University Of Texas System, The Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5061689A (en) * 1986-12-24 1991-10-29 Bioderm, Inc. Zinc bacitracin containing wound dressing
US4937747A (en) * 1988-02-16 1990-06-26 Amoco Corporation Iterative disjoint cluster and discriminant function processing of formation log responses and other data
US5129877A (en) * 1988-04-29 1992-07-14 University Of Georgia Research Foundation, Inc. Receptor-mediated delivery system
CA2045126A1 (en) * 1989-01-10 1990-07-11 Nicholas M. Gough Leukaemia inhibitory factor from livestock species and use thereof to enhance implantation and development of embryonic cells
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5571506A (en) * 1989-08-14 1996-11-05 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aromatic oligomeric compounds useful as mimics of bioactive macromolecules
DE69032406T2 (de) * 1989-08-23 1998-10-29 Zvi Fuks Wundheilmittel enthaltend heparanase
US5145679A (en) * 1989-10-05 1992-09-08 Hinson Joan B Topical emollient for prevention and treatment of circulatory induced lesions
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
US5633076A (en) * 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
EP0532695A1 (en) * 1990-05-31 1993-03-24 Board Of Regents, The University Of Texas System Immunochemical localization of heparanase in mouse and human melanomas
US5246698A (en) * 1990-07-09 1993-09-21 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
JPH04187408A (ja) 1990-11-21 1992-07-06 Toyo Ink Mfg Co Ltd 熱可塑性樹脂ペレットの製造方法およびその装置
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
US5714345A (en) * 1990-12-24 1998-02-03 Pharmaceutical Proteins Limited Increased expression of a gene by a second transferred mammary gland specific sequence transgenic
AU1228592A (en) * 1991-01-11 1992-08-17 American Red Cross Expression of active human protein c in mammary tissue of transgenic animals
US5300059A (en) 1991-11-19 1994-04-05 Hydro Slip Technologies Inc. Bloodbag and method of making same
US5360735A (en) * 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells
AU3882093A (en) 1992-03-23 1993-10-21 Geda International S.A. Use of antiviral coating for latex items such as condoms
FR2690162B1 (fr) * 1992-04-21 1995-08-04 Rhone Poulenc Rorer Sa Peptides ayant une activite de facteur d'echange du gdp, sequences d'acides nucleiques codant pour ces peptides, preparation et utilisation.
US5616483A (en) * 1992-06-11 1997-04-01 Aktiebolaget Astra Genomic DNA sequences encoding human BSSL/CEL
ATE314475T1 (de) * 1992-06-18 2006-01-15 Us Gov Health & Human Serv Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität
WO1994006442A1 (en) * 1992-09-11 1994-03-31 The Regents Of The University Of California Sulfated ligands for l-selectins and use of chlorates and or sulfatases for the treatment of inflammation
US5736137A (en) * 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
GB9225581D0 (en) * 1992-12-08 1993-01-27 Courtaulds Plc Wound dressings
US5474983A (en) * 1993-03-15 1995-12-12 The Research Foundation Of State University Of New York Method of inhibiting pro-inflammatory mediator release from basophils and mast cells
US5565193A (en) 1993-08-05 1996-10-15 Procter & Gamble Hair styling compositions containing a silicone grafted polymer and low level of a volatile hydrocarbon solvent
US5739115A (en) * 1993-10-07 1998-04-14 Glycomed Incorporated Sulfated maltooligosaccharides with heparin-like properties
US5618709A (en) * 1994-01-14 1997-04-08 University Of Pennsylvania Antisense oligonucleotides specific for STK-1 and method for inhibiting expression of the STK-1 protein
NZ281041A (en) * 1994-03-09 1998-04-27 Abbott Lab Non-human mammals transformed with a catalytic entity of enzymes or antibodies to produce a heterologous product in the animals milk
US5997863A (en) * 1994-07-08 1999-12-07 Ibex Technologies R And D, Inc. Attenuation of wound healing processes
US5830759A (en) * 1994-08-18 1998-11-03 The Trustees Of Columbia University In The City Of New York Unique associated Kaposi's sarcoma virus sequences and uses thereof
US5600366A (en) * 1995-03-22 1997-02-04 Npb Partners, Ltd. Methods and apparatus for digital advertisement insertion in video programming
US5799276A (en) * 1995-11-07 1998-08-25 Accent Incorporated Knowledge-based speech recognition system and methods having frame length computed based upon estimated pitch period of vocalic intervals
US5859929A (en) * 1995-12-01 1999-01-12 United Parcel Service Of America, Inc. System for character preserving guidelines removal in optically scanned text
WO1997023345A1 (en) 1995-12-21 1997-07-03 Contra-Shear Holdings Limited Screw press head
US5859660A (en) * 1996-02-29 1999-01-12 Perkins; Michael G. Non-seamless splicing of audio-video transport streams
US6314420B1 (en) * 1996-04-04 2001-11-06 Lycos, Inc. Collaborative/adaptive search engine
US6020931A (en) * 1996-04-25 2000-02-01 George S. Sheng Video composition and position system and media signal communication system
US5799311A (en) * 1996-05-08 1998-08-25 International Business Machines Corporation Method and system for generating a decision-tree classifier independent of system memory size
US5917830A (en) * 1996-10-18 1999-06-29 General Instrument Corporation Splicing compressed packetized digital video streams
US6699672B1 (en) * 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US6348344B1 (en) * 1997-09-02 2002-02-19 Insight Strategy & Marketing Ltd. Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same
US6153187A (en) * 1997-09-02 2000-11-28 Insight Strategy & Marketing Ltd. Use of glycosaminoglycans degrading enzymes for management of airway associated diseases
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US5968822A (en) * 1997-09-02 1999-10-19 Pecker; Iris Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells
US6190875B1 (en) * 1997-09-02 2001-02-20 Insight Strategy & Marketing Ltd. Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe
US6562950B2 (en) * 1997-09-02 2003-05-13 Insight Strategy & Marketing Ltd. Heparanase activity neutralizing anti-heparanase monoclonal antibody
US20030161823A1 (en) * 1998-08-31 2003-08-28 Neta Ilan Therapeutic and cosmetic uses of heparanases
BR9813296A (pt) * 1997-10-28 2000-08-22 Univ Australian Molécula isolada de ácido nucleico, processo para identificar uma molécula de ácido nucleico codificando um polipeptìdeo de endoglucuronidase de mamìfero, vetor de expressão, peptìdeo de heparanase isolado, polipeptìdeo recombinante ou isolado, molécula de anticorpo, processo para identificar um modulador da atividade de heparanase, uso de um oligossacarìdeo sulfatado, um sulfonato ou hspg compreendendo os mesmos, processos para tratamento de uma condição fisiológica ou médica em um sujeito humano ou animal em que a atividade de heparanase no referido sujeito é elevada, para intensificar a cura de feridas em um sujeito humano ou animal e para diagnosticar uma condição fisiológica ou médica associada com a super-expressão de heparanase, e, célula
EP1060252A2 (en) * 1998-02-24 2000-12-20 PHARMACIA & UPJOHN COMPANY Human platelet heparanase polypeptides, polynucleotide molecules that encode them, and methods for the identification of compounds that alter heparanase activity
US6230151B1 (en) * 1998-04-16 2001-05-08 International Business Machines Corporation Parallel classification for data mining in a shared-memory multiprocessor system
US6307965B1 (en) * 1998-04-30 2001-10-23 International Business Machines Corporation System and method for detecting clusters of information
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
US20030236215A1 (en) * 1998-08-31 2003-12-25 Insight Strategy & Marketing Ltd. Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
US6226792B1 (en) * 1998-10-14 2001-05-01 Unisys Corporation Object management system supporting the use of application domain knowledge mapped to technology domain knowledge
AU2878600A (en) * 1999-03-01 2000-09-21 Hadasit Medical Research Services & Development Company Ltd Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
JP3717420B2 (ja) * 2001-04-27 2005-11-16 シャープ株式会社 モバイルコンセント、電力供給ゲート装置、サーバ装置および電力利用管理システム
US20020194625A1 (en) * 2001-05-25 2002-12-19 Insight Strategy & Marketing Ltd. Transgenic animals expressing heparanase and its uses
AU2002351002A1 (en) * 2001-12-21 2003-07-09 Pfizer Products Inc. Transgenic expression of glycogen synthase kinase 3 in muscle
WO2004108065A2 (en) * 2003-06-09 2004-12-16 Insight Biopharmaceuticals Ltd. Heparanase activity neutralizing anti- heparanase monoclonal antibody and other anti-heparanase antibodies

Similar Documents

Publication Publication Date Title
JP2001517998A5 (cg-RX-API-DMAC10.html)
JP2002504007A5 (cg-RX-API-DMAC10.html)
JP2001517135A5 (cg-RX-API-DMAC10.html)
JP2001525151A5 (cg-RX-API-DMAC10.html)
JP2001518049A5 (cg-RX-API-DMAC10.html)
JP2001523302A5 (cg-RX-API-DMAC10.html)
JP2001524925A5 (cg-RX-API-DMAC10.html)
JP2001519989A5 (cg-RX-API-DMAC10.html)
JP2001525717A5 (cg-RX-API-DMAC10.html)
JP2001522401A5 (cg-RX-API-DMAC10.html)
JP2001522570A5 (cg-RX-API-DMAC10.html)
JP2002512533A5 (cg-RX-API-DMAC10.html)
JP2002500697A5 (cg-RX-API-DMAC10.html)
JP2001517276A5 (cg-RX-API-DMAC10.html)
JP2001523301A5 (cg-RX-API-DMAC10.html)
JP2001515691A5 (cg-RX-API-DMAC10.html)
JP2001520731A5 (cg-RX-API-DMAC10.html)
JP2001523358A5 (cg-RX-API-DMAC10.html)
JP2001516367A5 (cg-RX-API-DMAC10.html)
JP2001526842A5 (cg-RX-API-DMAC10.html)
JP2001527733A5 (cg-RX-API-DMAC10.html)
JP2001525682A5 (cg-RX-API-DMAC10.html)
JP2002500770A5 (cg-RX-API-DMAC10.html)
JP2001527696A5 (cg-RX-API-DMAC10.html)
JP2001520562A5 (cg-RX-API-DMAC10.html)