|
US6465188B1
(en)
*
|
1990-06-11 |
2002-10-15 |
Gilead Sciences, Inc. |
Nucleic acid ligand complexes
|
|
US6232071B1
(en)
*
|
1990-06-11 |
2001-05-15 |
Gilead Sciences, Inc. |
Tenascin-C nucleic acid ligands
|
|
US6395888B1
(en)
*
|
1996-02-01 |
2002-05-28 |
Gilead Sciences, Inc. |
High affinity nucleic acid ligands of complement system proteins
|
|
US6346611B1
(en)
|
1990-06-11 |
2002-02-12 |
Gilead Sciences, Inc. |
High affinity TGfβ nucleic acid ligands and inhibitors
|
|
US8071737B2
(en)
*
|
1995-05-04 |
2011-12-06 |
Glead Sciences, Inc. |
Nucleic acid ligand complexes
|
|
US6699843B2
(en)
|
1995-06-07 |
2004-03-02 |
Gilead Sciences, Inc. |
Method for treatment of tumors using nucleic acid ligands to PDGF
|
|
US6376604B2
(en)
|
1999-12-22 |
2002-04-23 |
Shearwater Corporation |
Method for the preparation of 1-benzotriazolylcarbonate esters of poly(ethylene glycol)
|
|
WO2001087351A1
(en)
*
|
2000-05-17 |
2001-11-22 |
Gilead Sciences, Inc. |
Method for treatment of tumors using nucleic acid ligands to pdgf
|
|
WO2002036073A2
(en)
*
|
2000-11-02 |
2002-05-10 |
Smithkline Beecham Corporation |
Receptor antagonist-lipid conjugates and delivery vehicles containing same
|
|
WO2002067849A2
(en)
*
|
2001-02-26 |
2002-09-06 |
Sabina Glozman |
Systems devices and methods for intrabody targeted delivery and reloading of therapeutic agents
|
|
PT1401853E
(pt)
|
2001-05-25 |
2010-12-07 |
Univ Duke |
Modulador de oligonucleotídeos
|
|
EP1481090A4
(en)
*
|
2002-02-15 |
2006-08-09 |
Somalogic Inc |
METHOD AND REAGENTS FOR DETECTING BINDING OF TARGET MOLECULES BY NUCLEIC ACID ELECTRODES
|
|
US20040249130A1
(en)
*
|
2002-06-18 |
2004-12-09 |
Martin Stanton |
Aptamer-toxin molecules and methods for using same
|
|
CA2487809A1
(en)
*
|
2002-06-18 |
2003-12-24 |
Archemix Corp. |
Aptamer-toxin molecules and methods for using same
|
|
JP2005533862A
(ja)
*
|
2002-07-25 |
2005-11-10 |
アーケミックス コーポレイション |
調節されたアプタマー治療剤
|
|
AU2003294437A1
(en)
*
|
2002-11-21 |
2004-06-18 |
Archemix Corporation |
Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same
|
|
US20040253243A1
(en)
*
|
2003-01-21 |
2004-12-16 |
David Epstein |
Aptamer therapeutics useful in ocular pharmacotherapy
|
|
US20090053138A1
(en)
*
|
2002-11-21 |
2009-02-26 |
Preiss Jeffrey R |
Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics
|
|
WO2006050498A2
(en)
|
2004-11-02 |
2006-05-11 |
Archemix Corp. |
Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
|
|
US10100316B2
(en)
*
|
2002-11-21 |
2018-10-16 |
Archemix Llc |
Aptamers comprising CPG motifs
|
|
US20050124565A1
(en)
*
|
2002-11-21 |
2005-06-09 |
Diener John L. |
Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
|
|
US8039443B2
(en)
*
|
2002-11-21 |
2011-10-18 |
Archemix Corporation |
Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
|
|
US8853376B2
(en)
*
|
2002-11-21 |
2014-10-07 |
Archemix Llc |
Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
|
|
EP1620547B1
(en)
|
2003-04-21 |
2014-06-18 |
Archemix LLC |
Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
|
|
US7727969B2
(en)
*
|
2003-06-06 |
2010-06-01 |
Massachusetts Institute Of Technology |
Controlled release nanoparticle having bound oligonucleotide for targeted delivery
|
|
US20040260034A1
(en)
|
2003-06-19 |
2004-12-23 |
Haile William Alston |
Water-dispersible fibers and fibrous articles
|
|
US7892993B2
(en)
|
2003-06-19 |
2011-02-22 |
Eastman Chemical Company |
Water-dispersible and multicomponent fibers from sulfopolyesters
|
|
US8513147B2
(en)
|
2003-06-19 |
2013-08-20 |
Eastman Chemical Company |
Nonwovens produced from multicomponent fibers
|
|
AU2004268614C1
(en)
*
|
2003-08-27 |
2010-10-28 |
Ophthotech Corporation |
Combination therapy for the treatment of ocular neovascular disorders
|
|
US7803931B2
(en)
|
2004-02-12 |
2010-09-28 |
Archemix Corp. |
Aptamer therapeutics useful in the treatment of complement-related disorders
|
|
HUE050481T2
(hu)
*
|
2004-02-12 |
2020-12-28 |
Archemix Llc |
Aptamer terapeutikumok, amelyek használhatók komplementtel kapcsolatos rendellenességek kezelésében
|
|
EP1756138A4
(en)
*
|
2004-03-05 |
2009-07-01 |
Archemix Corp |
APTAMERS FACILITATED TO THE FAMILY OF HUMAN IL-12 CYTOKINS AND THEIR USE AS THERAPEUTICS AGAINST AUTOIMMUNE DISEASES
|
|
US20060193821A1
(en)
*
|
2004-03-05 |
2006-08-31 |
Diener John L |
Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
|
|
US20080214489A1
(en)
*
|
2004-04-19 |
2008-09-04 |
Anthony Dominic Keefe |
Aptamer-mediated intracellular delivery of oligonucleotides
|
|
US7579450B2
(en)
*
|
2004-04-26 |
2009-08-25 |
Archemix Corp. |
Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
|
|
US7566701B2
(en)
*
|
2004-09-07 |
2009-07-28 |
Archemix Corp. |
Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
|
|
CA2578046A1
(en)
*
|
2004-09-07 |
2006-03-16 |
Archemix Corp. |
Aptamer medicinal chemistry
|
|
KR20070101227A
(ko)
|
2004-09-07 |
2007-10-16 |
아케믹스 코포레이션 |
폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도
|
|
DE602005012155D1
(de)
*
|
2004-11-03 |
2009-02-12 |
Liplasome Pharma As |
Arzneimittelabgabesysteme auf lipidbasis mit unnatürlichen phospholipase-a2-abbaubaren lipid-derivaten und ihre therapeutische verwendung
|
|
DE502005009920D1
(de)
*
|
2004-11-29 |
2010-08-26 |
Noxxon Pharma Ag |
Vasopressin bindende l-nukleinsäure
|
|
US20090075342A1
(en)
*
|
2005-04-26 |
2009-03-19 |
Sharon Cload |
Metabolic profile directed aptamer medicinal chemistry
|
|
US8101385B2
(en)
|
2005-06-30 |
2012-01-24 |
Archemix Corp. |
Materials and methods for the generation of transcripts comprising modified nucleotides
|
|
EP1907590B1
(en)
|
2005-06-30 |
2012-09-19 |
Archemix LLC |
T7 rna polymerase and methods for the generation of fully 2'-modified nucleic acid transcripts
|
|
US7922000B2
(en)
*
|
2006-02-15 |
2011-04-12 |
Miraial Co., Ltd. |
Thin plate container with a stack of removable loading trays
|
|
CA3009846C
(en)
|
2006-03-08 |
2021-08-31 |
David Epstein |
Complement binding aptamers and anti-c5 agents useful in the treatment of ocular disorders
|
|
US20090203766A1
(en)
*
|
2007-06-01 |
2009-08-13 |
Archemix Corp. |
vWF aptamer formulations and methods for use
|
|
US20090233295A1
(en)
*
|
2008-01-29 |
2009-09-17 |
Elias Georges |
Trim59 directed diagnostics for neoplastic disease
|
|
US8207298B2
(en)
*
|
2008-05-01 |
2012-06-26 |
Archemix Corp. |
Methods of separating biopolymer conjugated molecules from unconjugated molecules
|
|
EP2400985A2
(en)
|
2009-02-25 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor
|
|
JP2012519282A
(ja)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
|
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
EP2401614A1
(en)
|
2009-02-27 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
|
US8512519B2
(en)
|
2009-04-24 |
2013-08-20 |
Eastman Chemical Company |
Sulfopolyesters for paper strength and process
|
|
EP3028707A1
(en)
*
|
2009-05-01 |
2016-06-08 |
Ophthotech Corporation |
Methods for treating or preventing ophthalmological diseases
|
|
US8318923B2
(en)
*
|
2009-06-03 |
2012-11-27 |
Regado Biosciences, Inc. |
Nucleic acid modulators of glycoprotein VI
|
|
US8236570B2
(en)
|
2009-11-03 |
2012-08-07 |
Infoscitex |
Methods for identifying nucleic acid ligands
|
|
US8841429B2
(en)
|
2009-11-03 |
2014-09-23 |
Vivonics, Inc. |
Nucleic acid ligands against infectious prions
|
|
WO2012054668A2
(en)
*
|
2010-10-21 |
2012-04-26 |
Useastman Chemical Company |
Sulfopolyester binders
|
|
US9896730B2
(en)
|
2011-04-25 |
2018-02-20 |
OSI Pharmaceuticals, LLC |
Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
|
|
US8735367B2
(en)
*
|
2011-06-27 |
2014-05-27 |
University Of Utah Research Foundation |
Small molecule-dependent split aptamer ligation
|
|
ES2742284T3
(es)
|
2012-03-28 |
2020-02-13 |
Somalogic Inc |
Aptámeros contra PDGF y VEGF y su utilización en el tratamiento de afecciones mediadas por PDGF y VEGF
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
CN103290019B
(zh)
*
|
2013-06-14 |
2014-03-12 |
严鹏科 |
一种动脉粥样硬化的靶向适配子及其制备方法和应用
|
|
EA201690212A8
(ru)
*
|
2013-07-12 |
2016-08-31 |
Офтотек Корпорейшн |
Способы лечения или профилактики офтальмологических патологических состояний
|
|
CA3221709A1
(en)
|
2013-09-09 |
2015-03-12 |
Somalogic Operating Co., Inc. |
Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders
|
|
BR112016021547A2
(pt)
|
2014-03-17 |
2017-10-03 |
Glaxosmithkline Ip Dev Ltd |
Aptâmeros para envio tópico
|
|
WO2019109046A1
(en)
|
2017-11-30 |
2019-06-06 |
Arrakis Therapeutics, Inc. |
Nucleic acid-binding photoprobes and uses thereof
|