JP2002503687A5 - - Google Patents
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- Publication number
- JP2002503687A5 JP2002503687A5 JP2000532105A JP2000532105A JP2002503687A5 JP 2002503687 A5 JP2002503687 A5 JP 2002503687A5 JP 2000532105 A JP2000532105 A JP 2000532105A JP 2000532105 A JP2000532105 A JP 2000532105A JP 2002503687 A5 JP2002503687 A5 JP 2002503687A5
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- inner ear
- nucleic acid
- acid molecule
- ingredient according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004480 active ingredient Substances 0.000 description 28
- 210000003027 ear inner Anatomy 0.000 description 15
- 108020004707 nucleic acids Proteins 0.000 description 12
- 102000039446 nucleic acids Human genes 0.000 description 12
- 150000007523 nucleic acids Chemical class 0.000 description 12
- 230000006378 damage Effects 0.000 description 6
- 230000001953 sensory effect Effects 0.000 description 6
- 229940126074 CDK kinase inhibitor Drugs 0.000 description 5
- 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 description 5
- 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 5
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 description 5
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229940123587 Cell cycle inhibitor Drugs 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000004064 dysfunction Effects 0.000 description 4
- 239000013598 vector Substances 0.000 description 4
- 102000003903 Cyclin-dependent kinases Human genes 0.000 description 2
- 108090000266 Cyclin-dependent kinases Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 206010011891 Deafness neurosensory Diseases 0.000 description 1
- 208000009966 Sensorineural Hearing Loss Diseases 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002479 lipoplex Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 231100000879 sensorineural hearing loss Toxicity 0.000 description 1
- 208000023573 sensorineural hearing loss disease Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19807426.3 | 1998-02-23 | ||
| DE19807426A DE19807426A1 (de) | 1998-02-23 | 1998-02-23 | Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs |
| PCT/EP1999/001153 WO1999042088A2 (de) | 1998-02-23 | 1999-02-23 | Verfahren zur behandlung von erkrankungen oder störungen des innenohrs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002503687A JP2002503687A (ja) | 2002-02-05 |
| JP2002503687A5 true JP2002503687A5 (https=) | 2006-04-13 |
Family
ID=7858563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000532105A Pending JP2002503687A (ja) | 1998-02-23 | 1999-02-23 | 内耳の疾患又は機能障害の治療方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7087581B1 (https=) |
| EP (1) | EP1056467B1 (https=) |
| JP (1) | JP2002503687A (https=) |
| AT (1) | ATE250936T1 (https=) |
| AU (1) | AU763868B2 (https=) |
| CA (1) | CA2320717C (https=) |
| DE (2) | DE19807426A1 (https=) |
| DK (1) | DK1056467T3 (https=) |
| ES (1) | ES2211055T3 (https=) |
| PT (1) | PT1056467E (https=) |
| WO (1) | WO1999042088A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1471926E (pt) | 1999-06-01 | 2011-03-11 | Baylor College Medicine | Composições e métodos para a utilização terapêutica de uma sequência associada a atonal |
| DE10027777A1 (de) * | 2000-06-07 | 2001-12-13 | Otogene Ag | Transfektionsverfahren |
| KR100896489B1 (ko) * | 2000-07-11 | 2009-05-08 | 사운드 파마슈티칼스 인코퍼레이티드 | 내이에서 세포 재생 및 분화의 자극 |
| EP1547618B1 (en) | 2002-10-02 | 2010-05-26 | AnGes MG, Inc. | Drug for auditory dysfunction |
| DE60323876D1 (de) * | 2002-12-17 | 2008-11-13 | Centre Nat Rech Scient | Verwendung von purinderivaten zur induktion der differenzierung überzähliger haarzellen und deiter-zellen im entwickelnden corti-organ zur behandlung von taubheit |
| JP5524189B2 (ja) | 2008-06-06 | 2014-06-18 | クォーク ファーマシューティカルズ インコーポレーティッド | 耳障害治療のための組成物および方法 |
| DE102010007281A1 (de) | 2010-02-08 | 2011-08-11 | EMC microcollections GmbH, 72070 | Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger |
| RU2480195C1 (ru) * | 2011-11-02 | 2013-04-27 | Федеральное государственное учреждение "Российский научный центр восстановительной медицины и курортологии Федерального агентства по здравоохранению и социальному развитию РФ" (ФГУ "РНЦВМиК Росздрава РФ") | Способ лечения заболеваний внутреннего уха |
| EP2802657B1 (en) | 2012-01-12 | 2018-05-02 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
| WO2013134022A1 (en) * | 2012-03-05 | 2013-09-12 | Wake Forest University Health Sciences | Regeneration of inner ear cells |
| TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19528388A1 (de) | 1995-08-02 | 1997-02-06 | Hans Peter Prof Dr Med Zenner | Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs |
| JP2000505781A (ja) * | 1995-11-13 | 2000-05-16 | ケンブリッジ ニューロサイエンス インコーポレイテッド | 非視覚性感覚上皮の疾患の治療方法 |
| US5962224A (en) | 1995-12-19 | 1999-10-05 | Dana-Farber Cancer Institute | Isolated DNA encoding p62 polypeptides and uses therefor |
| AU3591597A (en) | 1996-06-28 | 1998-01-21 | Regents Of The University Of California, The | Transformation and genetherapy of cells of the inner ear |
| WO1998013048A1 (en) * | 1996-09-27 | 1998-04-02 | Trustees Of The University Of Pennsylvania | Novel methods for inducing proliferation in auditory receptor epithelium |
| US6043221A (en) | 1997-07-30 | 2000-03-28 | Amgen Inc. | Method for preventing and treating hearing loss using a neuturin protein product |
-
1998
- 1998-02-23 DE DE19807426A patent/DE19807426A1/de not_active Withdrawn
-
1999
- 1999-02-23 CA CA002320717A patent/CA2320717C/en not_active Expired - Fee Related
- 1999-02-23 PT PT99910259T patent/PT1056467E/pt unknown
- 1999-02-23 EP EP99910259A patent/EP1056467B1/de not_active Expired - Lifetime
- 1999-02-23 AU AU29281/99A patent/AU763868B2/en not_active Ceased
- 1999-02-23 JP JP2000532105A patent/JP2002503687A/ja active Pending
- 1999-02-23 DE DE59907195T patent/DE59907195D1/de not_active Expired - Fee Related
- 1999-02-23 WO PCT/EP1999/001153 patent/WO1999042088A2/de not_active Ceased
- 1999-02-23 ES ES99910259T patent/ES2211055T3/es not_active Expired - Lifetime
- 1999-02-23 US US09/622,719 patent/US7087581B1/en not_active Expired - Lifetime
- 1999-02-23 DK DK99910259T patent/DK1056467T3/da active
- 1999-02-23 AT AT99910259T patent/ATE250936T1/de not_active IP Right Cessation
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