JP2002501722A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002501722A5 JP2002501722A5 JP2000518692A JP2000518692A JP2002501722A5 JP 2002501722 A5 JP2002501722 A5 JP 2002501722A5 JP 2000518692 A JP2000518692 A JP 2000518692A JP 2000518692 A JP2000518692 A JP 2000518692A JP 2002501722 A5 JP2002501722 A5 JP 2002501722A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- conjugate
- conjugate peptide
- virus
- peptide according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 94
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 11
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 11
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 10
- 241000700605 Viruses Species 0.000 description 10
- 230000003115 biocidal effect Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 244000052769 pathogen Species 0.000 description 10
- 230000001717 pathogenic effect Effects 0.000 description 10
- ATEBXHFBFRCZMA-VXTBVIBXSA-N rifabutin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC(=C2N3)C(=O)C=4C(O)=C5C)C)OC)C5=C1C=4C2=NC13CCN(CC(C)C)CC1 ATEBXHFBFRCZMA-VXTBVIBXSA-N 0.000 description 10
- 229960000885 rifabutin Drugs 0.000 description 10
- 230000000890 antigenic effect Effects 0.000 description 9
- 150000001413 amino acids Chemical class 0.000 description 8
- 230000028993 immune response Effects 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 230000004962 physiological condition Effects 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 239000012148 binding buffer Substances 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- BXQZTMMXFKFJIY-UHFFFAOYSA-N 7-methoxy-2,6-dimethylisoquinoline-3,5,8-trione Chemical compound O=C1N(C)C=C2C(=O)C(OC)=C(C)C(=O)C2=C1 BXQZTMMXFKFJIY-UHFFFAOYSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 238000003776 cleavage reaction Methods 0.000 description 4
- 244000045947 parasite Species 0.000 description 4
- 230000007017 scission Effects 0.000 description 4
- MCAHMSDENAOJFZ-UHFFFAOYSA-N Herbimycin A Natural products N1C(=O)C(C)=CC=CC(OC)C(OC(N)=O)C(C)=CC(C)C(OC)C(OC)CC(C)C(OC)C2=CC(=O)C=C1C2=O MCAHMSDENAOJFZ-UHFFFAOYSA-N 0.000 description 3
- QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 description 3
- MCAHMSDENAOJFZ-BVXDHVRPSA-N herbimycin Chemical compound N1C(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@@H](OC)[C@@H](OC)C[C@H](C)[C@@H](OC)C2=CC(=O)C=C1C2=O MCAHMSDENAOJFZ-BVXDHVRPSA-N 0.000 description 3
- 241000224489 Amoeba Species 0.000 description 2
- 206010003571 Astrocytoma Diseases 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 241000194033 Enterococcus Species 0.000 description 2
- 241000709661 Enterovirus Species 0.000 description 2
- 241000588722 Escherichia Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 description 2
- SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical group NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 description 2
- 208000007514 Herpes zoster Diseases 0.000 description 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
- 241000701806 Human papillomavirus Species 0.000 description 2
- 241000588748 Klebsiella Species 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 102000018697 Membrane Proteins Human genes 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 241001430197 Mollicutes Species 0.000 description 2
- 241000186359 Mycobacterium Species 0.000 description 2
- 241000202934 Mycoplasma pneumoniae Species 0.000 description 2
- 102000029797 Prion Human genes 0.000 description 2
- 108091000054 Prion Proteins 0.000 description 2
- 241000725643 Respiratory syncytial virus Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 241000223109 Trypanosoma cruzi Species 0.000 description 2
- 241000607598 Vibrio Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 208000005017 glioblastoma Diseases 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- CNTFNBGPIPSDNW-UHFFFAOYSA-N mimosamycin Natural products COC1=C(C)C(=O)C2=CC(=C)N(C)C=C2C1=O CNTFNBGPIPSDNW-UHFFFAOYSA-N 0.000 description 2
- 230000002611 ovarian Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 241001430294 unidentified retrovirus Species 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000000837 carbohydrate group Chemical group 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 230000036211 photosensitivity Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96170797A | 1997-10-31 | 1997-10-31 | |
| US08/961,707 | 1997-10-31 | ||
| PCT/US1998/022335 WO1999022761A1 (en) | 1997-10-31 | 1998-10-22 | Conjugate heat shock protein-binding peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002501722A JP2002501722A (ja) | 2002-01-22 |
| JP2002501722A5 true JP2002501722A5 (https=) | 2006-01-05 |
Family
ID=25504878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000518692A Pending JP2002501722A (ja) | 1997-10-31 | 1998-10-22 | 熱ショックタンパク質結合性コンジュゲートペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20030134787A1 (https=) |
| EP (1) | EP1027070A4 (https=) |
| JP (1) | JP2002501722A (https=) |
| AU (1) | AU761432B2 (https=) |
| CA (1) | CA2308299A1 (https=) |
| IL (1) | IL135860A0 (https=) |
| WO (1) | WO1999022761A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6761892B1 (en) | 1995-08-18 | 2004-07-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US7235649B2 (en) * | 2000-03-24 | 2007-06-26 | Duke University | Isolated GRP94 ligand binding domain polypeptide and nucleic acid encoding same, and screening methods employing same |
| CA2406472A1 (en) * | 2000-04-17 | 2001-10-25 | James E. Rothman | Javelinization of protein antigens to heat shock proteins |
| EP1551957A4 (en) * | 2001-10-01 | 2007-01-24 | Univ Duke | ISOLATED POLYPEPTIDE OF THE GRP94 LIGANDEN BINDING DOMAIN AND NUCLEIC ACID, CRYSTALLINE FORM THEREOF, CODING THEREOF, AND SCRAPPING METHOD WHERE IT IS USED |
| US20030216315A1 (en) * | 2002-02-13 | 2003-11-20 | Duke University | Modulation of immune response by non-peptide binding stress response polypeptides |
| WO2003090686A2 (en) * | 2002-04-25 | 2003-11-06 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
| US7420037B2 (en) | 2003-02-13 | 2008-09-02 | Antigenics Inc. | Heat shock protein-based vaccines and immunotherapies |
| US7309491B2 (en) | 2003-04-11 | 2007-12-18 | Antigenics Inc. | Heat shock protein-based vaccines and immunotherapies |
| EP1617804A4 (en) * | 2003-04-11 | 2007-07-25 | Antigenics Inc | IMPROVED VACCINE BASED ON HEAT SHOCK PROTEINS AND IMMUNOTHERAPIES |
| US9296797B2 (en) * | 2007-07-03 | 2016-03-29 | Wisconsin Alumni Research Foundation | Phytochrome-based fluorophores |
| WO2010138727A1 (en) * | 2009-05-27 | 2010-12-02 | Wisconsin Alumni Research Foundation | Cyanochrome fluorophores |
| WO2011040421A1 (ja) | 2009-09-29 | 2011-04-07 | 武田薬品工業株式会社 | スクリーニング方法 |
| EA201792501A1 (ru) | 2015-05-13 | 2018-10-31 | Эйдженус Инк. | Вакцины для лечения и профилактики рака |
| MA52363A (fr) * | 2018-04-26 | 2021-03-03 | Agenus Inc | Compositions peptidiques de liaison à une protéine de choc thermique (hsp) et leurs méthodes d'utilisation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| US5348945A (en) * | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
| ES2171454T3 (es) * | 1993-06-04 | 2002-09-16 | Whitehead Biomedical Inst | Proteinas de estres y sus usos. |
| US5750119A (en) * | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
| US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| US5541109A (en) * | 1994-04-19 | 1996-07-30 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Expression cloning of c-src SH3-domain binding proteins |
| US6719974B1 (en) * | 1995-08-18 | 2004-04-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| IL123218A0 (en) * | 1995-08-18 | 1998-09-24 | Sloan Kettering Inst Cancer | Heat shock protein-based vaccines and immunotherapies |
| US5837251A (en) * | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
| US5935576A (en) * | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US5985270A (en) * | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
| US6127393A (en) * | 1995-12-29 | 2000-10-03 | Novactyl, Inc. | Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method |
| US6017540A (en) * | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| US5962262A (en) * | 1997-07-25 | 1999-10-05 | Incyte Pharmaceuticals, Inc. | Human heat shock 27 like protein |
-
1998
- 1998-10-22 IL IL13586098A patent/IL135860A0/xx unknown
- 1998-10-22 AU AU11130/99A patent/AU761432B2/en not_active Ceased
- 1998-10-22 WO PCT/US1998/022335 patent/WO1999022761A1/en not_active Ceased
- 1998-10-22 CA CA002308299A patent/CA2308299A1/en not_active Abandoned
- 1998-10-22 JP JP2000518692A patent/JP2002501722A/ja active Pending
- 1998-10-22 EP EP98953865A patent/EP1027070A4/en not_active Ceased
-
2002
- 2002-01-17 US US10/052,578 patent/US20030134787A1/en not_active Abandoned
- 2002-01-17 US US10/053,520 patent/US20030166530A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002501722A5 (https=) | ||
| US12297232B2 (en) | Compositions and methods for mucosal vaccination against SARS-CoV-2 | |
| JP4976653B2 (ja) | 免疫刺激性ＣｐＧオリゴヌクレオチドを用いてバイオテロ病原体による感染症を予防する方法 | |
| Moyle et al. | Modern subunit vaccines: development, components, and research opportunities | |
| Mizel et al. | Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates | |
| US7208478B2 (en) | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates | |
| JP5344558B2 (ja) | カチオン性ナノゲルを用いる粘膜ワクチン | |
| US20040057962A1 (en) | Immunogenic complex | |
| US8182821B2 (en) | Flu vaccine admixture of mannan and flu antigen | |
| US20080233181A1 (en) | Nanoparticle adjuvants for sub-unit vaccines | |
| KR20070029730A (ko) | 애쥬번트 처리된 시가 독소 ｂ-서브유닛을 기재로 하는 백신 | |
| CA2297101A1 (en) | Receptor specific transepithelial transport of therapeutics | |
| CN117897487A (zh) | 人工合成的含CpG单链脱氧寡核苷酸在疫苗中的应用 | |
| US20210107862A1 (en) | Methods and compositions for substance use disorder vaccine formulations and uses thereof | |
| NZ220027A (en) | Antigens or haptens coupled to escherichia coli outer membrane proteins for enhancement of immune response | |
| Zhong et al. | Lipid core peptide system for gene, drug, and vaccine delivery | |
| Dahhas et al. | Role of site-directed mutagenesis and adjuvants in the stability and potency of anthrax protective antigen | |
| MX2007014390A (es) | Composicion de vacuna que comprende subunidad b de termo toxina e. coli y antigeno y adyuvante. | |
| Kimishima et al. | Investigations into the efficacy of multi-component cocaine vaccines | |
| Eng et al. | PCEP enhances IgA mucosal immune responses in mice following different immunization routes with influenza virus antigens | |
| Shivachandra et al. | Immunogenicity of recombinant Omp16 protein of Pasteurella multocida B: 2 in mouse model | |
| EP0166548A2 (en) | Broad spectrum vaccine against gonorrhea | |
| US4622223A (en) | Broad spectrum vaccine against gonorrhea | |
| US20030068324A1 (en) | Conjugate vaccine composed of the polysaccharide moiety of the lipopolysaccharide of Vibrio cholerae O139 bound to tetanus toxoid | |
| Lobaina et al. | A nasal vaccine candidate based on S2 and N proteins from SARS-CoV-2 generates a broad antibody response systemically and in the lower respiratory tract |