JP2002330794A - 新規遺伝子及びそれにコードされる蛋白質 - Google Patents

Abstract

(57)【要約】 （修正有） 【課題】ヒト成人全脳、ヒト成人海馬及びヒト胎児全脳
由来のｃＤＮＡライブラリーから、蛋白質をコードして
いる領域を含む新規なＤＮＡを直接クローニングし、そ
れらの塩基配列を決定し、更にそれらの機能を同定する
こと。 【解決手段】以下の（ａ）又は（ｂ）のポリペプチドを
コードする塩基配列を含むＤＮＡ：（ａ）特定の配列：
１乃至４５のいずれか一つで示されるアミノ酸配列と同
一又は実質的に同一のアミノ酸配列から成るポリペプチ
ド、（ｂ）特定の配列：１乃至４５のいずれか一つで示
されるアミノ酸配列において、一部のアミノ酸が欠失、
置換又は付加されたアミノ酸配列から成り、（ａ）のポ
リペプチドの機能と実質的に同質の生物学的活性を有す
るポリペプチド、上記ＤＮＡにコードされる組換えポリ
ペプチド、及び該ポリペプチドを含む蛋白質。

Description

【発明の詳細な説明】

【０００１】

【発明の属する技術分野】本発明は、ＤＮＡ及び該ＤＮ
Ａを含む遺伝子、並びに該ＤＮＡにコードされる組換え
ポリペプチド及び該ポリペプチドを含む新規組換え蛋白
質に関する。

【０００２】

【従来の技術】ヒトゲノム計画における大規模シークエ
ンシングによって、ヒトゲノムの塩基配列に関する情報
が日々産出されている。ヒトゲノム計画の最終目的は単
にゲノム全塩基配列を決定することではなく、その構造
情報、即ち、ＤＮＡの塩基配列情報からヒトのさまざま
な生命現象を読み解くことにあろう。ヒトゲノム配列中
で蛋白質をコードしている領域はその極一部であり、現
在は、ニュートラルネットワークや隠れマルコフモデル
と呼ばれる情報科学の手法を用いて、そのコード領域の
予測が行われている。しかしながら、それらの予測精度
はまだ充分なものではない。

【０００３】今回、本発明者は新規な遺伝子を見出すべ
く、ヒト成人全脳、ヒト成人海馬及びヒト胎児全脳由来
のｃＤＮＡライブラリーから、蛋白質をコードしている
領域を含む新規なＤＮＡを直接クローニングすることに
成功し、それらの塩基配列を決定して本発明を完成させ
た。

【０００４】

【課題を解決するための手段】即ち、本発明は第一の態
様として、以下の（ａ）又は（ｂ）のポリペプチドをコ
ードする塩基配列を含むＤＮＡに係る： （ａ）配列番号：１乃至４５のいずれか一つで示される
アミノ酸配列と同一又は実質的に同一のアミノ酸配列か
ら成るポリペプチド、（ｂ）配列番号：１乃至４５のい
ずれか一つで示されるアミノ酸配列において、一部のア
ミノ酸が欠失、置換又は付加されたアミノ酸配列から成
り、（ａ）のポリペプチドの機能と実質的に同質の生物
学的活性を有するポリペプチド。本発明の第二の態様と
して、以下の（ａ）又は（ｂ）のＤＮＡに係る： （ａ）配列番号：１乃至４５のいずれか一つで示される
塩基配列において、夫々の配列で示されるアミノ酸配列
をコードする塩基配列を含むＤＮＡ、(ｂ）（ａ）のＤ
ＮＡとストリンジェントな条件下でハイブリダイズし、
（ａ）のポリペプチドの機能と実質的に同質の生物学的
活性を有する蛋白質をコードするＤＮＡ。以上の本発明
の第一及び第二の態様であるＤＮＡをまとめて、以下、
「本発明ＤＮＡ」ともいう。又、本発明はこれらＤＮＡ
を含む遺伝子にも係る。更に、本発明は上記ＤＮＡ又は
遺伝子にコードされる組換えポリペプチド（以下、「本
発明ポリペプチド」ともいう。）、及び該ポリペプチド
を含む組換え蛋白質に係る。

【０００５】本発明ＤＮＡを有するクローンの名称、本
発明ポリペプチド又は蛋白質の長さ、その機能について
は、表１乃至表３に示されている。

【０００６】本発明ＤＮＡは、市販されている（クロン
テック社）ヒト成人全脳、ヒト成人海馬及びヒト胎児全
脳のｍＲＮＡを出発材料として、本発明者が調製したｃ
ＤＮＡライブラリーから、ｃＤＮＡ断片として単離した
後に、塩基配列を決定し同定したものである。即ち、具
体的には、小原他の方法（DNA Research Vol.4,53−59
（1997））に従って調製したヒト成人全脳、ヒト成人海
馬及びヒト胎児全脳由来のｃＤＮＡライブラリーからク
ローンをランダムに単離する。次に、ハイブリダイゼー
ションにより、重複クローン（繰り返し出てくるクロー
ン）を除き、その後インビトロでの転写翻訳を行い５０
ｋＤａ以上の産物が認められるクローンについてその両
末端の塩基配列を決定する。更に、こうして得られた末
端塩基配列をクエリーとして既知遺伝子のデータベース
に相同性検索を行い、その結果、新規であることが判明
したクローンについて全塩基配列を決定する。このよう
にして既知の遺伝子に依存した従来のクローニング方法
では得られなかった未知の遺伝子も、システマチックに
クローニングを行なうことができる。又、短い断片や得
られた配列に人工的な間違いが起こらないように十分な
注意を払いながら、ＲＡＣＥ等のＰＣＲ法を使用するこ
とによっても、本発明ＤＮＡを含むヒト由来遺伝子の全
領域を調製することも可能である。

【０００７】更に、本発明は、本発明ＤＮＡ又は本発明
ＤＮＡを含む遺伝子を含有する組換えベクター、該組換
えベクターを保持する形質転換体、該形質転換体を培養
し、本発明ポリペプチド若しくは該ポリペプチドを含む
組換え蛋白質を生成、蓄積せしめ、これを採取すること
を特徴とする、本発明ポリペプチド若しくは該ポリペプ
チドを含む組換え蛋白質、又はその塩の製造方法、及
び、こうして得られる本発明ポリペプチド若しくは該ポ
リペプチドを含む組換え蛋白質又はその塩を提供する。

【０００８】又、本発明は、本発明ＤＮＡ又は遺伝子を
含有してなる医薬、本発明ポリペプチド若しくはその部
分ポリペプチド又は該ポリペプチドを含む組換え蛋白質
をコードする塩基配列を含むポリヌクレオチド（ＤＮ
Ａ）、それら塩基配列に実質的に相補的な塩基配列を有
するアンチセンスヌクレオチド、該ポリヌクレオチド又
はアンチセンスヌクレオチドを含有してなる医薬、本発
明ポリペプチド若しくはその部分ポリペプチド、及び、
該ポリペプチド又はそれらを含む組換え蛋白質を含有し
てなる医薬に係る。更に、本発明は、本発明ポリペプチ
ド若しくはその部分ポリペプチド又は該ポリペプチドを
含む組換え蛋白質又はそれらの塩に対する抗体、及び、
本発明ポリペプチド、その部分ポリペプチド若しくは該
ポリペプチドを含む組換え蛋白質又はそれらの塩、又は
それらに対する抗体を用いることを特徴とする、それら
物質と特異的に相互作用する物質のスクリーニング方
法、スクリーニング用キット、並びに、該スクリーニン
グ方法によって同定される物質（化合物）自体等にも係
る。

【０００９】

【発明の実施の形態】本発明ＤＮＡとしては、前述した
本発明ポリペプチドをコードする塩基配列から成るもの
であればいかなるものであってもよい。また、ヒトの
脳、又は、それ以外の組織、例えば、心臓、肺、肝臓、
脾臓、腎臓、精巣、等の細胞・組織に由来するｃＤＮＡ
ライブラリー等から同定・単離されたｃＤＮＡ、又は、
合成ＤＮＡのいずれでもよい。ライブラリー作成に使用
するベクターは、バクテリオファージ、プラスミド、コ
スミド、ファージミドなどいずれであってもよい。ま
た、前記した細胞・組織よりtotalＲＮＡ画分またはｍ
ＲＮＡ画分を調製したものを用いて、直接ReverseTrans
cription coupled Polymerase Chain Reaction（以下、
「ＲＴ-ＰＣＲ法」と略称する）によって増幅すること
もできる。

【００１０】配列番号：１乃至４５のいずれか一つで示
されるアミノ酸配列と実質的に同一のアミノ酸配列と
は、配列番号：１乃至４５のいずれか一つで示される全
アミノ酸配列との相同性の程度が、全体の平均で約７０
％以上、好ましくは約８０％以上、更に好ましくは約９
０％以上、特に好ましくは約９５％以上であるアミノ酸
配列を意味する。従って、本発明の配列番号：１乃至４
５のいずれか一つで示されるアミノ酸配列と実質的に同
一のアミノ酸配列から成るポリペプチドとしては、例え
ば、前記の各配列番号で示されるアミノ酸配列に対して
上記の相同性を有し、各配列番号で示されるアミノ酸配
列から成るポリペプチドの機能と実質的に同質の生物学
的活性（機能）を有するポリペプチドを挙げることが出
来る。ここで、実質的に同質とは、それらの活性（機
能）が性質的に同質であることを示す。又、本発明ポリ
ペプチドには、例えば、配列番号：１乃至４５のいずれ
か一つで示されるアミノ酸配列中の一部（好ましくは、
１〜２０個程度、より好ましくは１〜１０個程度、さら
に好ましくは数個）のアミノ酸が欠失、置換又は付加し
たアミノ酸配列、或いはそれらを組み合わせたアミノ酸
配列から成り、配列番号：１乃至４５のいずれか一つで
示されるアミノ酸配列から成るポリペプチドの機能と実
質的に同質の生物学的活性（機能）を有するポリペプチ
ドも含まれる。

【００１１】上記の配列番号：１乃至４５のいずれか一
つで示されるアミノ酸配列と実質的に同一のアミノ酸配
列から成るポリペプチド、又はその一部のアミノ酸が欠
失、置換又は付加したアミノ酸配列から成るポリペプチ
ドは、例えば、部位特異的変異導入法、遺伝子相同組換
え法、プライマー伸長法、及びＰＣＲ法等の当業者に周
知の方法を適宜組み合わせて、容易に作成することが可
能である。尚、その際に、実質的に同質の生物学的活性
を有するためには、当該ポリペプチドを構成するアミノ
酸のうち、同族アミノ酸（極性・非極性アミノ酸、疎水
性・親水性アミノ酸、陽性・陰性荷電アミノ酸、芳香族
アミノ酸など）同士の置換が可能性として考えられる。
又、実質的に同質の生物学的活性の維持のためには、本
発明の各ポリペプチドに含まれる機能ドメイン内のアミ
ノ酸は保持されることが望ましい。

【００１２】更に、本発明ＤＮＡは、配列番号：１乃至
４５のいずれか一つで示される塩基配列において、夫々
の配列で示されるアミノ酸配列をコードする塩基配列を
含むＤＮＡ、及び、該ＤＮＡとストリンジェントな条件
下でハイブリダイズし、各配列で示されるアミノ酸配列
から成るポリペプチドの機能と同質の生物学的活性（機
能）を有するポリペプチド（蛋白質）をコードするＤＮ
Ａを包含する。かかる条件下で、配列番号：１乃至４５
のいずれか一つで示される塩基配列において、夫々の配
列で示されるアミノ酸配列をコードする塩基配列を含む
ＤＮＡとハイブリダイズできるＤＮＡとしては、例え
ば、該ＤＮＡの全塩基配列との相同性の程度が、全体の
平均で約８０％以上、好ましくは約９０％以上、より好
ましくは約９５％以上である塩基配列を含有するＤＮＡ
等を挙げることが出来る。ハイブリダイゼーションは、
カレント・プロトコールズ・イン・モレキュラー・バイ
オロジー（Current protocols in molecular biology
（edited by Frederick M. Ausubel et al., 1987））
に記載の方法等、当業界で公知の方法あるいはそれに準
じる方法に従って行なうことができる。また、市販のラ
イブラリーを使用する場合、添付の使用説明書に記載の
方法に従って行なうことができる。ここで、「ストリン
ジェントな条件」とは、例えば、６５℃の1mM EDTA ナ
トリウム、0.5M リン酸水素ナトリウム（pH7.2）、７％
SDS 水溶液中でハイブリダイズさせ、６５℃の1mM EDTA
ナトリウム、４０mM リン酸水素ナトリウム（pH7.
2）、１％SDS 水溶液中でメンブレンを洗浄する条件で
のサザンブロットハイブリダイゼーションで本発明ＤＮ
Ａプローブにハイブリダイズする程度の条件である。

【００１３】本発明ＤＮＡのクローニングの手段として
は、本発明ポリペプチドの部分等の適当な塩基配列を有
する合成ＤＮＡプライマーを用いてＰＣＲ法によって増
幅するか、または適当なベクターに組み込んだＤＮＡを
本発明ポリペプチドの一部あるいは全領域をコードする
ＤＮＡ断片もしくは合成ＤＮＡを用いて標識したものと
のハイブリダイゼーションによって選別することができ
る。ハイブリダイゼーションの方法は、例えば、上記の
Current protocols in molecular biology（edited by
Frederick M. Ausubel et al., 1987）に記載の方法な
どに従って行なうことができる。また、市販のライブラ
リーを使用する場合、添付の使用説明書に記載の方法に
従って行なうことができる。クローン化されたポリペプ
チドをコードするＤＮＡは目的によりそのまま、または
所望により制限酵素で消化したり、リンカーを付加した
りして使用することができる。該ＤＮＡはその５’末端
側に翻訳開始コドンとしてのＡＴＧを有し、また３’末
端側には翻訳終止コドンとしてのＴＡＡ、ＴＧＡまたは
ＴＡＧを有していてもよい。これらの翻訳開始コドンや
翻訳終止コドンは、適当な合成ＤＮＡアダプターを用い
て付加することもできる。

【００１４】本発明の蛋白質の発現ベクターは、当該技
術分野で公知の方法に従って作成することが出来る。例
えば、（１）本発明ＤＮＡ又は本発明ＤＮＡを含む遺伝
子を含有するＤＮＡ断片を切り出し、（２）該ＤＮＡ断
片を適当な発現ベクター中のプロモーターの下流に連結
することにより製造することができる。ベクターとして
は、大腸菌由来のプラスミド（例、ｐＢＲ３２２，ｐＢ
Ｒ３２５，ｐＵＣ１８，ｐＵＣ１１８）、枯草菌由来の
プラスミド（例、ｐＵＢ１１０，ｐＴＰ５，ｐＣ１９
４）、酵母由来プラスミド（例、ｐＳＨ１９，ｐＳＨ１
５）、λファージなどのバクテリオファージ、レトロウ
イルス，ワクシニアウイルス，バキュロウイルスなどの
動物ウイルス等を利用することが出来る。本発明で用い
られるプロモーターとしては、遺伝子の発現に用いる宿
主に対応した適切なプロモーターであればいかなるもの
でもよい。例えば、宿主が大腸菌である場合は、ｔｒｐ
プロモーター、ｌａｃプロモーター、ｒｅｃＡプロモー
ター、λＰLプロモーター、ｌｐｐプロモーターなど
が、宿主が枯草菌である場合は、ＳＰＯ１プロモータ
ー、ＳＰＯ２プロモーター、ｐｅｎＰプロモーターな
ど、宿主が酵母である場合は、ＰＨＯ５プロモーター、
ＰＧＫプロモーター、ＧＡＰプロモーター、ＡＤＨプロ
モーターなどが好ましい。動物細胞を宿主として用いる
場合は、ＳＲαプロモーター、ＳＶ４０プロモーター、
ＬＴＲプロモーター、ＣＭＶプロモーター、ＨＳＶ-Ｔ
Ｋプロモーターなどが挙げられる。

【００１５】発現ベクターには、以上の他に、所望によ
り当該技術分野で公知の、エンハンサー、スプライシン
グシグナル、ポリＡ付加シグナル、選択マーカー、ＳＶ
４０複製オリジン等を付加することができる。また、必
要に応じて、本発明のＤＮＡにコードされた蛋白質を他
の蛋白質（例えば、グルタチオンＳトランスフェラーゼ
及びプロテインＡ）との融合蛋白質として発現させるこ
とも可能である。このような融合蛋白質は、適当なプロ
テアーゼを使用して切断し、それぞれの蛋白質に分離す
ることが出来る。

【００１６】宿主細胞としては、例えば、エシェリヒア
属菌、バチルス属菌、酵母、昆虫細胞、昆虫、動物細胞
などが用いられる。エシェリヒア属菌の具体例として
は、エシェリヒア・コリ（Escherichia coli）Ｋ１２・
ＤＨ１（Proc. Natl. Acad. Sci. ＵＳＡ，６０巻，１
６０(１９６８)），ＪＭ１０３（Nucleic Acids Resear
ch，９巻，３０９(１９８１)），ＪＡ２２１（Journal
of Molecular Biology，１２０巻，５１７(１９７
８)），及びＨＢ１０１（Journal of Molecular Biolog
y，４１巻，４５９(１９６９)）等が用いられる。バチ
ルス属菌としては、例えば、バチルス・サチルス（Baci
llus subtilis）ＭＩ１１４（Gene，２４巻，２５５(１
９８３)），２０７−２１〔Journal of Biochemistry，
９５巻，８７(１９８４)〕等が用いられる。酵母として
は、例えば、サッカロマイセス セレビシエ（Saccaromy
ces cerevisiae）ＡＨ２２，ＡＨ２２Ｒ-，ＮＡ８７−
１１Ａ，ＤＫＤ−５Ｄ，２０Ｂ−１２、シゾサッカロマ
イセス ポンベ（Schizosaccaromyces pombe）ＮＣＹＣ
１９１３，ＮＣＹＣ２０３６、サッカロマイセス ピキ
ア パストリス（Saccaromycespicjia pastoris）等が用
いられる。動物細胞としては、例えば、サル細胞ＣＯＳ
−７，Ｖero，チャイニーズハムスター細胞ＣＨＯ（以
下、ＣＨＯ細胞と略記），ｄｈｆｒ遺伝子欠損ＣＨＯ細
胞，マウスＬ細胞，マウスＡｔＴ−２０，マウスミエロ
ーマ細胞，ラットＧＨ３，ヒトＦＬ細胞などが用いられ
る。

【００１７】これら宿主細胞の形質転換は、当該技術分
野で公知の方法に従って行うことが出来る。例えば、以
下に記載の文献を参照することが出来る。Proc. Natl.
Acad. Sci. ＵＳＡ，６９巻，２１１０(１９７２)； Ge
ne，１７巻，１０７(１９８２)；Molecular ＆ General
Genetics，１６８巻，１１１(１９７９)；Methods in
Enzymology，１９４巻，１８２−１８７（１９９１）；
Proc. Natl. Acad. Sci. ＵＳＡ），７５巻，１９２９
(１９７８)；細胞工学別冊８ 新 細胞工学実験プロトコ
ール．２６３−２６７（１９９５）（秀潤社発行）；及
び Virology，５２巻，４５６(１９７３)。

【００１８】このようにして得られた、本発明ＤＮＡ又
は本発明ＤＮＡを含む遺伝子を含有する発現ベクターで
形質転換された形質転換体は、当該技術分野で公知の方
法に従って培養することが出来る。例えば、以下に記載
の文献を参照することが出来る。例えば、宿主がエシェ
リヒア属菌の場合、培養は通常約１５〜４３℃で約３〜
２４時間行ない、必要により、通気や撹拌を加えること
もできる。宿主がバチルス属菌の場合、培養は通常、約
３０〜４０℃で約６〜２４時間行ない、必要により通気
や撹拌を加えることもできる。宿主が酵母である形質転
換体を培養する際、培養は通常、ｐＨ約５〜８に調整さ
れた培地を用いて約２０℃〜３５℃で約２４〜７２時間
行ない、必要に応じて通気や撹拌を加えることもでき
る。宿主が動物細胞である形質転換体を培養する際、ｐ
Ｈは約６〜８に調整された培地を用いて、通常約３０℃
〜４０℃で約１５〜６０時間行ない、必要に応じて通気
や撹拌を加えることもできる。

【００１９】上記培養物から本発明ポリペプチド又は蛋
白質を分離精製するには、例えば、培養後、公知の方法
で菌体あるいは細胞を集め、これを適当な緩衝液に懸濁
し、超音波、リゾチームおよび／または凍結融解などに
よって菌体あるいは細胞を破壊したのち、遠心分離やろ
過により蛋白質の粗抽出液を得る。緩衝液の中に尿素や
塩酸グアニジンなどの蛋白質変性剤や、トリトンＸ−１
００^TMなどの界面活性剤が含まれていてもよい。培養液
中に蛋白質が分泌される場合には、培養終了後、公知の
方法で菌体あるいは細胞と上清とを分離し、上清を集め
る。このようにして得られた培養上清、あるいは抽出液
中に含まれる蛋白質の精製は、公知の分離・精製法を適
切に組み合わせて行なうことができる。こうして得られ
た本発明ポリペプチド（蛋白質）は、公知の方法あるい
はそれに準じる方法によって塩に変換することができ、
逆に塩で得られた場合には公知の方法あるいはそれに準
じる方法により、遊離体または他の塩に変換することが
できる。更に、組換え体が産生する蛋白質を、精製前ま
たは精製後に、トリプシン及びキモトリプシンのような
適当な蛋白修飾酵素を作用させることにより、任意に修
飾を加えたり、ポリペプチドを部分的に除去することも
できる。本発明ポリペプチド（蛋白質）又はその塩の存
在は、様々な結合アッセイ及び特異抗体を用いたエンザ
イムイムノアッセイ等により測定することができる。

【００２０】本発明ポリペプチド（蛋白質）は、Ｃ末端
が通常カルボキシル基（−ＣＯＯＨ）またはカルボキシ
レート(−ＣＯＯ-）であるが、Ｃ末端がアミド（−ＣＯ
ＮＨ ₂）またはエステル（−ＣＯＯＲ）であってもよ
い。ここでエステルにおけるＲとしては、例えば、メチ
ル、エチル、ｎ−プロピル、イソプロピルもしくはｎ−
ブチルなどのＣ1-6アルキル基、例えば、シクロペンチ
ル、シクロヘキシルなどのＣ3-8シクロアルキル基、例
えば、フェニル、α−ナフチルなどのＣ6-12アリール
基、例えば、ベンジル、フェネチルなどのフェニル−Ｃ
1-2アルキル基もしくはα−ナフチルメチルなどのα−
ナフチル−Ｃ1-2アルキル基などのＣ7-14アラルキル基
のほか、経口用エステルとして汎用されるピバロイルオ
キシメチルエステルなどが用いられる。

【００２１】本発明ポリペプチド（蛋白質）がＣ末端以
外にカルボキシル基（またはカルボキシレート）を有し
ている場合、カルボキシル基がアミド化またはエステル
化されているものも本発明の蛋白質に含まれる。この場
合のエステルとしては、例えば上記したＣ末端のエステ
ルなどが用いられる。さらに、本発明の蛋白質には、Ｎ
末端のメチオニン残基のアミノ基が保護基（例えば、ホ
ルミル基、アセチル基などのＣ1-6アシル基など）で保
護されているもの、生体内で切断されて生成するＮ末端
のグルタミン酸残基がピログルタミン化したもの、分子
内のアミノ酸の側鎖上にある、例えばＯＨ、ＣＯＯＨ、
ＮＨ₂、ＳＨなどが適当な保護基（例えば、ホルミル
基、アセチル基などのＣ1-6アシル基など）で保護され
ているもの、あるいは糖鎖が結合したいわゆる糖蛋白質
などの複合蛋白質なども含まれる。

【００２２】本発明の蛋白質の部分ポリペプチドとして
は、前記した本発明ポリペプチド（蛋白質）の部分ペプ
チドであって、実質的に同質の活性を有するものであれ
ばいずれのものでもよい。例えば、本発明ポリペプチド
（蛋白質）の構成アミノ酸配列のうち少なくとも１０個
以上、好ましくは５０個以上、さらに好ましくは７０個
以上、より好ましくは１００個以上、最も好ましくは２
００個以上のアミノ酸配列を有し、例えば、本発明のポ
リペプチドの機能と実質的に同質の生物学的活性を有す
るするペプチドなどが用いられる。本発明の部分ポリペ
プチドとしては、例えば、各機能ドメインを含むものが
好ましい。又、本発明の部分ペプチドはＣ末端が通常カ
ルボキシル基（−ＣＯＯＨ）またはカルボキシレート
（−ＣＯＯ-）であるが、前記した本発明の蛋白質のご
とく、Ｃ末端がアミド（−ＣＯＮＨ₂）またはエステル
（−ＣＯＯＲ）であってもよい。さらに、本発明の部分
ペプチドには、前記した本発明の蛋白質と同様に、Ｎ末
端のメチオニン残基のアミノ基が保護基で保護されてい
るもの、Ｎ端側が生体内で切断され生成したグルタミル
基がピログルタミン酸化したもの、分子内のアミノ酸の
側鎖上の置換基が適当な保護基で保護されているもの、
あるいは糖鎖が結合したいわゆる糖ペプチドなどの複合
ペプチドなども含まれる。本発明の部分ペプチドは、例
えば、試薬、実験の際の標準物質、又は免疫源若しくは
その一部として使用することが出来る。

【００２３】本発明ポリペプチド（蛋白質）又はその部
分ペプチドの塩としては、とりわけ生理学的に許容され
る酸付加塩が好ましい。この様な塩としては、例えば、
無機酸（例えば、塩酸、リン酸、臭化水素酸、硫酸）と
の塩、あるいは有機酸（例えば、酢酸、ギ酸、プロピオ
ン酸、フマル酸、マレイン酸、コハク酸、酒石酸、クエ
ン酸、リンゴ酸、蓚酸、安息香酸、メタンスルホン酸、
ベンゼンスルホン酸）との塩などが用いられる。

【００２４】本発明ポリペプチド（蛋白質）、その部分
ペプチドもしくはそれらの塩またはそれらのアミド体
は、当該技術分野で公知の化学合成方法を用いて調製す
ることも出来る。例えば、通常市販されている蛋白質合
成用樹脂を用い、α−アミノ基と側鎖官能基を適当に保
護したアミノ酸を、目的とする蛋白質の配列通りに、当
業界において自体公知の各種縮合方法に従い、樹脂上で
縮合させる。反応の最後に樹脂から蛋白質を切り出すと
同時に各種保護基を除去し、さらに高希釈溶液中で分子
内ジスルフィド結合形成反応を実施し、目的の蛋白質、
その部分ペプチドまたはそれらのアミド体を取得する。
上記した保護アミノ酸の縮合に関しては、例えば、DC
C、N,N'-ジイソプロピルカルボジイミド、及びN-エチル
-N'-(3-ジメチルアミノプロリル）カルボジイミドのよ
うなカルボジイミド類に代表される蛋白質合成に使用で
きる各種活性化試薬を用いることができる。これらによ
る活性化にはラセミ化抑制添加剤（例えば、HOBt, HOOB
t)とともに保護アミノ酸を直接樹脂に添加するかまた
は、対称酸無水物またはHOBtエステルあるいはHOOBtエ
ステルとしてあらかじめ保護アミノ酸の活性化を行なっ
た後に樹脂に添加することができる。

【００２５】保護アミノ酸の活性化や樹脂との縮合に用
いられる溶媒としては、酸アミド類、ハロゲン化炭化水
素類、アルコール類、スルオキシド類、及びエーテル類
等、当業界において蛋白質縮合反応に使用しうることが
知られている溶媒から適宜選択されうる。反応温度は蛋
白質結合形成反応に使用され得ることが知られている範
囲から適宜選択される。活性化されたアミノ酸誘導体は
通常１.５〜４倍過剰で用いられる。ニンヒドリン反応
を用いたテストの結果、縮合が不十分な場合には保護基
の脱離を行うことなく縮合反応を繰り返すことにより十
分な縮合を行なうことができる。反応を繰り返しても十
分な縮合が得られないときには、無水酢酸またはアセチ
ルイミダゾールを用いて未反応アミノ酸をアセチル化し
て、後の反応に影響を及ぼさないようにすることができ
る。原料の各アミノ基、カルボキシル基、及びセリン水
酸基等の保護基としても、当該技術分野において、通常
使用される基を使用することができる。原料の反応に関
与すべきでない官能基の保護ならびに保護基、およびそ
の保護基の脱離、反応に関与する官能基の活性化などは
公知の基または公知の手段から適宜選択しうる。

【００２６】本発明の部分ペプチドまたはそれらの塩
は、当該技術分野において自体公知のペプチドの合成法
に従って、あるいは本発明の蛋白質を適当なペプチダー
ゼで切断することによって製造することができる。ペプ
チドの合成法としては、例えば、固相合成法、液相合成
法のいずれによっても良い。公知の縮合方法や保護基の
脱離としては、例えば、以下の（１）〜（３）に記載さ
れた方法が挙げられる。 （１）泉屋信夫他、ペプチド合成の基礎と実験、 丸善
(株) （1975年） （２）矢島治明 および榊原俊平、生化学実験講座 1、
蛋白質の化学IV、 205、(1977年) （３）矢島治明監修、続医薬品の開発 第14巻 ペプチド
合成 広川書店 反応後の精製も自体公知の方法、例えば、溶媒抽出・蒸
留・カラムクロマトグラフィー・液体クロマトグラフィ
ー・再結晶などを組み合わせて本発明の部分ペプチドを
精製単離することができる。上記方法で得られる部分ペ
プチドが遊離体である場合は、公知の方法によって適当
な塩に変換することができるし、逆に塩で得られた場合
は、公知の方法によって遊離体に変換することができ
る。

【００２７】本発明ポリペプチド（蛋白質）、その部分
ペプチドまたはそれらの塩に対する抗体は、それらを認
識し得るものであれば、ポリクローナル抗体、モノクロ
ーナル抗体の何れであってもよい。本発明ポリペプチド
（蛋白質）、その部分ペプチドまたはそれらの塩に対す
る抗体は、本発明ポリペプチド（蛋白質）又はその部分
ペプチドを抗原として用い、公知の抗体または抗血清の
製造法に従って製造することができる。本発明の抗体
は、体液や組織などの被検体中に存在する本発明ポリペ
プチド（蛋白質）等を検出するために使用することがで
きる。また、これらを精製するために使用する抗体カラ
ムの作製、精製時の各分画中の本発明ポリペプチド（蛋
白質）の検出、被検細胞内における本発明ポリペプチド
（蛋白質）の挙動の分析などのために使用することがで
きる。

【００２８】更に、本発明の抗体は、公知の方法による
被検液中の本発明ポリペプチド（蛋白質）等の定量、特
に、モノクローナル抗体を使用したサンドイッチ免疫測
定法による定量、及び組織染色等による検出などに使用
することができる。それによって、例えば、本発明ポリ
ペプチド（蛋白質）等が関与する疾病の診断を行なうこ
とができる。これらの目的には、抗体分子そのものを用
いてもよく、また、抗体分子のＦ(ａｂ')2 、Ｆａｂ'、
あるいはＦａｂ画分を用いてもよい。本発明の抗体を用
いる本発明の蛋白質等の定量法は、特に制限されるべき
ものではなく、被測定液中の抗原量（例えば、蛋白質
量）に対応した抗体、抗原もしくは抗体−抗原複合体の
量を化学的または物理的手段により検出し、これを既知
量の抗原を含む標準液を用いて作製した標準曲線より算
出する測定法であれば、いずれの測定法を用いてもよ
い。例えば、ネフロメトリー、競合法、イムノメトリッ
ク法およびサンドイッチ法が好適に用いられるが、感
度、特異性の点で、後述するサンドイッチ法を用いるの
が好ましい。標識物質を用いる測定法に用いられる標識
剤としては、当該技術分野で公知の、例えば、放射性同
位元素、酵素、蛍光物質、発光物質などを用いることが
出来る。

【００２９】これらの測定・検出方法に関する一般的な
技術手段の詳細については、総説、成書などを参照する
ことができる。例えば、入江 寛編「続ラジオイムノア
ッセイ〕（講談社、昭和５４年発行）、石川栄治ら編
「酵素免疫測定法」（第３版）（医学書院、昭和６２年
発行）、「Methods in ENZYMOLOGY」Vol. 70(Immunoche
mical Techniques(Part A))、 同書 Vol. 73(Immunoche
mical Techniques(PartB))、 同書 Vol. 74(Immunochem
ical Techniques(Part C))、 同書 Vol. 84(Immunochem
ical Techniques(Part D:Selected Immunoassays))、
同書 Vol. 92(Immunochemical Techniques(Part E:Mono
clonal Antibodies and General Immunoassay Method
s))、 同書 Vol. 121(Immunochemical Techniques(Part
I:HybridomaTechnology and Monoclonal Antibodies))
(以上、アカデミックプレス社発行)などを参照すること
ができる。

【００３０】本発明ポリペプチド（蛋白質）又はその部
分ポリペプチドをコードするＤＮＡに実質的に相補的な
塩基配列を有するアンチセンスオリゴヌクレオチド（Ｄ
ＮＡ）としては、当該ＤＮＡの塩基配列に実質的に相補
的な塩基配列を有し、該ＤＮＡの発現を抑制し得る作用
を有するものであれば、いずれのアンチセンスＤＮＡで
あってもよい。実質的に相補的な塩基配列とは、例え
ば、本発明ＤＮＡに相補的な塩基配列の全塩基配列また
は部分塩基配列と好ましくは約９０以上、より好ましく
は約９５％以上、最も好ましくは１００％の相同性を有
する塩基配列などが挙げられる。又、これらアンチセン
スＤＮＡと同様の作用を有する核酸配列（ＲＮＡまたは
ＤＮＡの修飾体）も本発明でいうアンチセンスＤＮＡに
含まれる。これらのアンチセンスＤＮＡは、公知のＤＮ
Ａ合成装置などを用いて製造することができる。

【００３１】更に、本発明ポリペプチド（蛋白質）等
は、これら物質と特異的に相互作用する化合物をスクリ
ーニングする為の試薬として有用である。すなわち、本
発明は、本発明ポリペプチド（蛋白質）、その部分ペプ
チド若しくはそれらの塩、又はそれらに対する抗体を用
いることを特徴とする、該物質又はそれらの塩と特異的
に相互作用する化合物のスクリーニング方法、及びその
為のスクリーニング用キットを提供する。本発明のスク
リーニング方法またはスクリーニング用キットを用いて
同定される化合物またはその塩は、上記した試験化合物
から選ばれた化合物であり、本発明ポリペプチド（蛋白
質）等と相互作用し、その生物学的活性を調節、阻害、
促進、又は拮抗等する化合物である。該化合物またはそ
の塩は、本発明の蛋白質等の活性に直接作用するもので
あってもよいし、本発明ポリペプチド（蛋白質）等の発
現に作用することによって間接的に本発明ポリペプチド
（蛋白質）等の活性に作用するものであってもよい。該
化合物の塩としては、例えば、薬学的に許容可能な塩な
どが用いられる。例えば、無機塩基との塩、有機塩基と
の塩、無機酸との塩、有機酸との塩、塩基性または酸性
アミノ酸との塩などがあげられる。本発明ポリペプチド
（蛋白質）等の生物学的活性を阻害する化合物も上記各
種疾病に対する治療・予防剤などの医薬として使用でき
る可能性がある。

【００３２】本発明ＤＮＡ及び該ＤＮＡを含む遺伝子を
プローブとして使用することにより、本発明ポリペプチ
ド又はその部分ペプチドをコードするＤＮＡまたはｍＲ
ＮＡの異常（遺伝子異常）を検出することができるの
で、例えば、該ＤＮＡまたはｍＲＮＡの損傷、突然変異
あるいは発現低下や、該ＤＮＡまたはｍＲＮＡの増加あ
るいは発現過多などの遺伝子診断剤として有用である。
本発明のＤＮＡを用いる上記の遺伝子診断は、例えば、
公知のノーザンハイブリダイゼーションやＰＣＲ−ＳＳ
ＣＰ法（Genomics，第５巻，８７４〜８７９頁（１９８
９年）、Proceedings of the National Academy of Sci
ences of the United States of America，第８６巻，
２７６６〜２７７０頁（１９８９年））などにより実施
することができる。更に、本発明ＤＮＡ又は遺伝子に異
常があったり、欠損している場合あるいは発現量が減少
している場合、生体内において正常な機能を発揮できな
い患者に対しては、公知手段に従って（１）レトロウイ
ルスベクター、アデノウイルスベクター、アデノウイル
スアソシエーテッドウイルスベクターなどの適当なベク
ターをベヒクルとして使用する遺伝子治療によって、本
発明ＤＮＡ又は遺伝子を該患者体内に導入し、発現させ
るか、又は（２）本発明の蛋白質等を該患者に注入する
こと等によって、該患者において本発明の蛋白質等の機
能を発揮させることができるものと考えられる。本発明
ＤＮＡ又は遺伝子を、該ＤＮＡを単独、又は、摂取促進
のための補助剤とともに、遺伝子銃やハイドロゲルカテ
ーテルのようなカテーテルによって投与することも可能
である。

【００３３】本明細書において、塩基やアミノ酸などを
略号で表示する場合、ＩＵＰＡＣ−ＩＵＢ Commision o
n Biochemical Nomenclature による略号あるいは当該
分野における慣用略号に基づくものであり、またアミノ
酸に関し光学異性体があり得る場合は、特に明示しなけ
ればＬ体を示すものとする。

【００３４】

【実施例】以下に、実施例により本発明をさらに具体的
に説明するが、本発明はそれに限定されるものではな
い。なお、実施例における各種遺伝子操作は、上記のCu
rrent protocols in molecular biology（edited by Fr
ederick M. Ausubel et al.,1987）に記載されている方
法に従った。

【００３５】（１）ヒト成人全脳、ヒト成人海馬及びヒ
ト胎児全脳由来ｃＤＮＡライブラリーの構築 ＮｏｔＩ部位を有するオリゴヌクレオチド（ＧＡＣＴＡ
ＧＴＴＣＴＡＧＡＴＣＧＣＧＡＧＣＧＧＣＣＧＣＣＣ
（Ｔ）_１５）（インビトロジェン）をプライマーとし
て、ヒト成人全脳、ヒト成人海馬及びヒト胎児全脳由来
ｍＲＮＡ（クローンテック社）を鋳型にSuperScriptII
逆転写酵素キット（インビトロジェン）で２本鎖ｃＤＮ
Ａを合成した。ＳａｌＩ部位を有するアダプター（イン
ビトロジェン）をｃＤＮＡとライゲーションした。その
後、ＮｏｔＩ消化し、１％濃度の低融解アガロース電気
泳動により、３ｋｂ以上のＤＮＡ断片を精製した。精製
ｃＤＮＡ断片を、ＳａｌＩ−ＮｏｔＩ制限酵素処理した
pBluescript IISK＋ プラスミドとライゲーションし
た。大腸菌 ElectroMax DH10B 株（インビトロジェン）
にエレクトロポレーション法によりこの組換えプラスミ
ドを導入した。

【００３６】（２）スクリーニング 次いで、こうして構築したｃＤＮＡライブラリーからラ
ンダムにクローンをピックアップし、メンブランにスポ
ッティングした。次に、これまでに本発明者等によって
既に全長の解析が行われている約1,300個のクローンの
塩基配列に基づき作成したオリゴＤＮＡ（各２１塩基）
の混合物の各３’末端をターミナルトランスフェラーゼ
でＤＩＧラベルし、これらをプルーブとして使用してド
ットハイブリダイゼーション（Current protocols in m
olecular biology（edited by Frederick M. Ausubel e
t al., 1987））により、重複クローン（繰り返し出て
くるクローン）を除いた。次に、インビトロでの転写翻
訳（プロメガ社TNT T7 Quick Coupled Transcription/T
ranslation System cat.no.L1107）を行い、５０ｋＤａ
以上の産物が認められるクローンを選択した。次に、選
択したクローンの末端塩基配列を決定し、得られた配列
をクエリーとして相同検索プログラムBLASTN 2.0.14 (A
ltschul, Stephen F., Thomas L. Madden, Alejandro
A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Mill
er, andDavid J. Lipman (1997), "Gapped BLAST and P
SI-BLAST: a new generation of protein database sea
rch programs", Nucleic Acids Res. 25:3389-3402)を
用いて、nr(All GenBank+EMBL+DDBJ+PDB sequences (bu
t no EST, STS,GSS, orphase 0,1 or 2 HTGS sequence
s))データベースに対して相同検索を行った。その結
果、相同遺伝子が存在しなかったもの、即ち、新規遺伝
子であるものについて全塩基配列を決定した。配列決定
には、ＰＥアプライドバイオシステム社製のＤＮＡシー
クエンサー（ABI PRISM377）と同社製反応キットを使用
した。大部分の配列はショットガンクローンをダイター
ミネーター法を用いて決定した。一部の塩基配列につい
ては、決定した塩基配列を元にしてオリゴヌクレオチド
を合成し、プライマーウォーキング法で決定した。

【００３７】このようにして新規ＤＮＡ又は遺伝子のス
クリーニングを行なった。その結果、配列表の配列番号
１乃至４５のいずれか一つに示された新規ＤＮＡ又は遺
伝子が検出された。これらの新規ＤＮＡ又は遺伝子につ
いて、上記の配列決定方法によりその塩基配列を決定し
た。本発明ＤＮＡ又は遺伝子を有するクローンの名称は
表１及び表２に示されている。

【００３８】（３）本発明ＤＮＡの相同性検索 次に、こうして得られた全塩基配列に基づき、クローン
のアミノ酸配列を既知配列ライブラリーnr release 122
に対して解析プログラムBLASTP 2.0.14 (Altschul, Ste
phen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang,Zheng Zhang, Webb Miller, and David
J. Lipman (1997), "Gapped BLAST andPSI-BLAST: a ne
w generation of protein database search programs",
Nucleic Acids Res. 25:3389-3402)を用いて検索した
ところ表３〜表５に示した各相同遺伝子と相同性を示す
ことが明らかになった。尚、表３〜表５には、これら相
同遺伝子に関する情報、即ち、その名称、データベース
ＩＤ、生物種、蛋白質長、及び記載文献が挙げられてい
る。又、これら各表中の「生物種」の略号の意味は表６
で説明されている。

【００３９】更に、各クローンに含まれる本発明ＤＮＡ
又は遺伝子と表３〜表５に示した各相同遺伝子との相同
性に関する各種データを表７及び表８にまとめた。これ
ら表中の各項目の意味は以下の通りである。 「Score」この値が高ければ高いほど信頼度が高い 「E-value」この値が0に近ければ近いほど信頼度が高い 「相同性」相同領域のアミノ酸残基の一致の割合 「相同範囲率」相同遺伝子中の相同領域の割合

【００４０】（４）各種ドメインの検索 次に、クローンに含まれるＤＮＡがコードするアミノ酸
配列をクエリーとし、Pfam 6.0に含まれる検索ツールPf
am HMM ver 2.1 Search (HMMPFAM) (Sonnhammer ELL, E
ddy SR, Birney E, Bateman A, Durbin R (1998) Pfam:
multiple sequence alignments and HMM-profiles of
protein domains, Nucleic Acids Research 26:320-32
2)を用いて機能ドメインを検索した。更に、膜蛋白予測
プログラムであるSOSUI system (ver. 1.0 / 10, Mar.,
1996) (Takatsugu Hirokawa, Seah Boon-Chieng and S
higeki Mitaku, SOSUI: Classification and Secondary
Structure Prediction System for Membrane Protein
s, Bioinformatics (formerly CABIOS) 1998 May;14
(4):378-379.) を用いて膜貫通ドメインを検索した。こ
れらの検出された機能ドメイン及び膜貫通ドメインを表
９〜表１５にそれぞれのクローンについて示した。これ
ら表中の各項目の意味は以下の通りである。 「機能ドメイン」Pfam SOSUIにより検出されたドメイン 「クローン from」機能ドメインの起点 「クローン to」機能ドメインの終点 「相同遺伝子 from」機能ドメインの起点 「相同遺伝子 to」機能ドメインの終点 「Score(Pfamのみ)」この値が高ければ高いほど信頼度
が高い 「Exp(Pfamのみ)」この値が0に近ければ近いほど信頼度
が高い 又、各機能ドメインの完全標記を表１６に示した。

【００４１】（５）発現部位 RT-PCR ELISAを用いて、組織と脳の部位での発現を、そ
れぞれで一番強い発現を示したものを表１７及び表１８
に示した。尚、組織及び脳の部位の完全標記を表１９に
示した。 （６）染色体位置 クローンのDNA酸配列をクエリーとし、既知配列ライブ
ラリーGenbank release119に対応するヒトゲノム配列に
対して解析プログラムBLASTN 2.0.14 (Altschul, Steph
en F., Thomas L. Madden, Alejandro A. Schaffer, Ji
nghui Zhang, Zheng Zhang, Webb Miller, and David
J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a n
ew generation of protein database search program
s", NucleicAcids Res. 25:3389-3402)を用いて検索し
た。適合したクローンの説明(Definition)の中からこの
クローンが由来した染色体の番号の記述を抽出し、これ
を表１７及び表１８に示した。

【００４２】以上の、相同性、相同性遺伝子に関する情
報、各種ドメイン、発現部位、及び染色体位置、等に基
づき、当業者であれば、本発明のＤＮＡ又は遺伝子が表
１及び表２に示した各機能を有するものと予測すること
が出来る。尚、以下のクローンに含まれる遺伝子が完全
長であることは、以下の理由により判定した。 aj00273：マウスEos proteinとのアライメントからヒト
Eos proteinの完全長であると考えられる。

【００４３】本発明で得られた新規なＤＮＡ又は遺伝子
を所謂ＤＮＡチップ等に集積させ、これに、例えば、精
神病等の脳が関与する疾患の患者と対照としての正常人
の血液又は組織等から作成したプローブをハイブリダイ
ゼーションさせることによって、これら疾患の診断、治
療等に役立てることが出来る。又、本発明のＤＮＡ若し
くは遺伝子又はそれらの一部の塩基配列に基づき作成し
た合成ＤＮＡプライマーを使用し、ヒトの血液又は組織
から抽出した染色体ＤＮＡを用いてＰＣＲを行い、その
産物の塩基配列を決定することにより、本発明のＤＮＡ
又は遺伝子中にある個体によって異なる一塩基の変異、
即ち、ｃＳＮＩＰｓを見出すことが出来る。これによ
り、個体の体質等が予測され、各自に適した医薬の開発
等が可能となる。又、クロスハイブリダイゼーションに
より、マウス等のモデル生物における本発明のＤＮＡ又
は遺伝子に対するオルソログ（ホモログ、カウンターパ
ート）遺伝子を単離し、例えば、これら遺伝子をノック
アウトすることによってヒトの疾患モデル動物を作成
し、ヒトの病因となる遺伝子を探索・同定することも可
能である。更に、本発明のＤＮＡ又は遺伝子に対する抗
体を網羅的に作成し、それらを集積させて所謂ＰＲＯＴ
ＥＩＮチップを作成し、患者と正常人との蛋白質発現量
の差異を検出する等のプロテオーム解析から、病気の診
断・治療等に役立てることが出来る。

【００４４】

【表１】

【００４５】

【表２】

【００４６】

【表３】

【００４７】

【表４】

【００４８】

【表５】

【００４９】

【表６】

【００５０】

【表７】

【００５１】

【表８】

【００５２】

【表９】

【００５３】

【表１０】

【００５４】

【表１１】

【００５５】

【表１２】

【００５６】

【表１３】

【００５７】

【表１４】

【００５８】

【表１５】

【００５９】

【表１６】

【００６０】

【表１７】

【００６１】

【表１８】

【００６２】

【表１９】

【００６３】

【配列表】 SEQUENCE LISTING <110> Kazusa DNA Research Institute <120> Novel Genes and Proteins Encoded by the Genes <130> AB02009 <160> 45 <170> PatentIn Ver. 2.1 <210> 1 <211> 7484 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(6344) <400> 1 tg ctc act tct gac agc cag aca agg gct gtg ctc agg ggc agc tcg 47 Leu Thr Ser Asp Ser Gln Thr Arg Ala Val Leu Arg Gly Ser Ser 1 5 10 15 gct ggg cac aca gta ggt gct tta gcg gac agc act gag gcc ccc agc 95 Ala Gly His Thr Val Gly Ala Leu Ala Asp Ser Thr Glu Ala Pro Ser 20 25 30 aag aag ccc atg agc tcc tcc ccc tcc cgc agt gcc gcc gac atc tac 143 Lys Lys Pro Met Ser Ser Ser Pro Ser Arg Ser Ala Ala Asp Ile Tyr 35 40 45 atc cgg gag tat ttc cac agc cac gtc agc ggc ggc cac ccc gag gcc 191 Ile Arg Glu Tyr Phe His Ser His Val Ser Gly Gly His Pro Glu Ala 50 55 60 act cct ctc cgt gtg atg tac acg gac cgg ccg ctg agc cag acg gac 239 Thr Pro Leu Arg Val Met Tyr Thr Asp Arg Pro Leu Ser Gln Thr Asp 65 70 75 cca gtc acg ctg cag tac tgt tgc ctg acc gac gac cgc cag gct ttc 287 Pro Val Thr Leu Gln Tyr Cys Cys Leu Thr Asp Asp Arg Gln Ala Phe 80 85 90 95 cgc ccg ccc aca cgg gca gag ctg gcg cgg cac cgc gtg gtg gtc acc 335 Arg Pro Pro Thr Arg Ala Glu Leu Ala Arg His Arg Val Val Val Thr 100 105 110 acc acc tcc cag gcc cgt gag ctc agg gtg ccg gtc ggc ttc ttc tcc 383 Thr Thr Ser Gln Ala Arg Glu Leu Arg Val Pro Val Gly Phe Phe Ser 115 120 125 cac att ctc atc gat gag gcg gcc cag atg ctg gag tgc gag gcc ctc 431 His Ile Leu Ile Asp Glu Ala Ala Gln Met Leu Glu Cys Glu Ala Leu 130 135 140 acc ccg ctg gcc tac gcc tcg cac ggc acc cgc ctc gtg ctg gcg ggc 479 Thr Pro Leu Ala Tyr Ala Ser His Gly Thr Arg Leu Val Leu Ala Gly 145 150 155 gac cac atg cag gtc aca ccc cgg ctg ttc agt gtg gcc agg gcc cgg 527 Asp His Met Gln Val Thr Pro Arg Leu Phe Ser Val Ala Arg Ala Arg 160 165 170 175 gcg gcc gag cac acg ctg ctg cac cgc ctc ttc ctg tgc tac cag cag 575 Ala Ala Glu His Thr Leu Leu His Arg Leu Phe Leu Cys Tyr Gln Gln 180 185 190 gag act cac gag gtg gcg cgg cag agc cgc ctg gtc ttc cac gag aac 623 Glu Thr His Glu Val Ala Arg Gln Ser Arg Leu Val Phe His Glu Asn 195 200 205 tac cgc tgc acg gac gcc att gtc agc ttc atc tcg cgg cac ttc tac 671 Tyr Arg Cys Thr Asp Ala Ile Val Ser Phe Ile Ser Arg His Phe Tyr 210 215 220 gtg gcc aag ggc aac ccc atc cac gcc agg ggc aag gtt ccg ccc cac 719 Val Ala Lys Gly Asn Pro Ile His Ala Arg Gly Lys Val Pro Pro His 225 230 235 ccc cgg cac tac ccg ctc atg ttc tgc cac gtg gcg ggc aac cca gac 767 Pro Arg His Tyr Pro Leu Met Phe Cys His Val Ala Gly Asn Pro Asp 240 245 250 255 cgg gac atg tcc atg gcg tcc tgg ctg aat ctg gct gag att gcg cag 815 Arg Asp Met Ser Met Ala Ser Trp Leu Asn Leu Ala Glu Ile Ala Gln 260 265 270 gtc gtc gag aag gtg cag gag gcc tac aac acc tgg ccc agc tgc tgg 863 Val Val Glu Lys Val Gln Glu Ala Tyr Asn Thr Trp Pro Ser Cys Trp 275 280 285 ggc ggc cgt gag cag agg tgc atc tgt gtc gtt tcc cac ggt gcc cag 911 Gly Gly Arg Glu Gln Arg Cys Ile Cys Val Val Ser His Gly Ala Gln 290 295 300 gtc agt gca ctg agg cag gag ctg agg agg cgg gac cta ggc cag gtg 959 Val Ser Ala Leu Arg Gln Glu Leu Arg Arg Arg Asp Leu Gly Gln Val 305 310 315 tct gtc ggc agt ttt gag atc ctg cca ggg cgg cag ttc cgg gtc gtg 1007 Ser Val Gly Ser Phe Glu Ile Leu Pro Gly Arg Gln Phe Arg Val Val 320 325 330 335 gtg ctc agc act gtg cac acc tgc cag agc ctg ctc agc cct ggg gca 1055 Val Leu Ser Thr Val His Thr Cys Gln Ser Leu Leu Ser Pro Gly Ala 340 345 350 ctg gcc cct gag ttc ttc acc gac gcc cgc gtg ctc aac acc gtc ctg 1103 Leu Ala Pro Glu Phe Phe Thr Asp Ala Arg Val Leu Asn Thr Val Leu 355 360 365 acc cgc gcc cag tcc cag ctg gtg gta gtg ggg gac gcc gtg gcc ctc 1151 Thr Arg Ala Gln Ser Gln Leu Val Val Val Gly Asp Ala Val Ala Leu 370 375 380 tgc tcc ttc ggg gcc tgc ggc aag ctc tgg gag agc ttc atc cgt gag 1199 Cys Ser Phe Gly Ala Cys Gly Lys Leu Trp Glu Ser Phe Ile Arg Glu 385 390 395 tgc gtg gag cgg cac agt gtc tgc ccc gag ggc ctg tcc atg gag cag 1247 Cys Val Glu Arg His Ser Val Cys Pro Glu Gly Leu Ser Met Glu Gln 400 405 410 415 gtc gag cag ggt gtg gcg cag aga cgg cgc tgg cct ccc cga ggc aca 1295 Val Glu Gln Gly Val Ala Gln Arg Arg Arg Trp Pro Pro Arg Gly Thr 420 425 430 cag gct ggg gca gcg ggg aac tgg gag gct gcc cca gag cca gta ggg 1343 Gln Ala Gly Ala Ala Gly Asn Trp Glu Ala Ala Pro Glu Pro Val Gly 435 440 445 gac ctg gcc gag gag cag gcg gct gtg gtg acg gcc atg gtg aag gca 1391 Asp Leu Ala Glu Glu Gln Ala Ala Val Val Thr Ala Met Val Lys Ala 450 455 460 gag ccg gga gat gag gct ctg agc cca gca tcc cgt gac atc acg gca 1439 Glu Pro Gly Asp Glu Ala Leu Ser Pro Ala Ser Arg Asp Ile Thr Ala 465 470 475 acc aca gcg cag acg gag gct gcg gca gca cca gca gga gac gca gtg 1487 Thr Thr Ala Gln Thr Glu Ala Ala Ala Ala Pro Ala Gly Asp Ala Val 480 485 490 495 aag gaa gac gtg gtg ccc ggg gcc tgt gcg gca gga gcg gct gct gca 1535 Lys Glu Asp Val Val Pro Gly Ala Cys Ala Ala Gly Ala Ala Ala Ala 500 505 510 gcg ggc gtg gag tcc acg gag gct gag gat gca gag gct gac ttc tgg 1583 Ala Gly Val Glu Ser Thr Glu Ala Glu Asp Ala Glu Ala Asp Phe Trp 515 520 525 ccg tgg gac ggg gag ctc aac gct gac gac gcc atc cta cgg gag ctt 1631 Pro Trp Asp Gly Glu Leu Asn Ala Asp Asp Ala Ile Leu Arg Glu Leu 530 535 540 ctg gac gag agc cag aag gtg atg gtg acc gtc ggg gag gac ggg ctg 1679 Leu Asp Glu Ser Gln Lys Val Met Val Thr Val Gly Glu Asp Gly Leu 545 550 555 ctg gac acc gtc gcc agg ccc gag tcc ctg cag cag gcc cgg ctg tac 1727 Leu Asp Thr Val Ala Arg Pro Glu Ser Leu Gln Gln Ala Arg Leu Tyr 560 565 570 575 gag aac ctg ccc ccg gct gcg cta cgg aag ctg ctg cgc gcg gag ccc 1775 Glu Asn Leu Pro Pro Ala Ala Leu Arg Lys Leu Leu Arg Ala Glu Pro 580 585 590 gag cgg tac cgc cac tgc tct ttc gtg cca gag acc ttc gag cgg gcg 1823 Glu Arg Tyr Arg His Cys Ser Phe Val Pro Glu Thr Phe Glu Arg Ala 595 600 605 tca gcc atc ccg ctg gac gat gcc tcc tcg ggc ccc atc cag gtc agg 1871 Ser Ala Ile Pro Leu Asp Asp Ala Ser Ser Gly Pro Ile Gln Val Arg 610 615 620 ggc cgc ctg gac tgt ggg atg gcc ttc gcc ggg gat gag gtg ctg gtg 1919 Gly Arg Leu Asp Cys Gly Met Ala Phe Ala Gly Asp Glu Val Leu Val 625 630 635 cag ctc ctt tcg gga gac aag gcg ccc gag ggg cgg ctt cgg ggc cgc 1967 Gln Leu Leu Ser Gly Asp Lys Ala Pro Glu Gly Arg Leu Arg Gly Arg 640 645 650 655 gtg ctg ggc gtg ctg aag agg aag agg cac gag ctg gcg ttt gtg tgc 2015 Val Leu Gly Val Leu Lys Arg Lys Arg His Glu Leu Ala Phe Val Cys 660 665 670 cgc atg gac acg tgg gac ccg cgc atc atg gtc ccc atc aat ggc tcc 2063 Arg Met Asp Thr Trp Asp Pro Arg Ile Met Val Pro Ile Asn Gly Ser 675 680 685 gtg acc aag atc ttc gtg gcc gag ctg aag gac cca tcg cag gtc ccc 2111 Val Thr Lys Ile Phe Val Ala Glu Leu Lys Asp Pro Ser Gln Val Pro 690 695 700 atc tac agc ctc cgg aag ggc cgg ctg cag cgt gtg ggg ctt gag agg 2159 Ile Tyr Ser Leu Arg Lys Gly Arg Leu Gln Arg Val Gly Leu Glu Arg 705 710 715 ctc acc gcc gag gcc cgg cac agc cgg ctc ttc tgg gtc caa att gtc 2207 Leu Thr Ala Glu Ala Arg His Ser Arg Leu Phe Trp Val Gln Ile Val 720 725 730 735 ctg tgg cgg caa ggc ttc tac tac ccg ctg ggc atc gtc cgg gag gtg 2255 Leu Trp Arg Gln Gly Phe Tyr Tyr Pro Leu Gly Ile Val Arg Glu Val 740 745 750 ctg cct gag gcc agc acc tgg gag cag ggc ctc cgc atc ctc ggc ctg 2303 Leu Pro Glu Ala Ser Thr Trp Glu Gln Gly Leu Arg Ile Leu Gly Leu 755 760 765 gag tac agc ttg agg gtg ccc ccg tcg gac cag gcc acc atc acc aag 2351 Glu Tyr Ser Leu Arg Val Pro Pro Ser Asp Gln Ala Thr Ile Thr Lys 770 775 780 gtg ctg cag aaa tac cac acg gag ctt ggc cgg gtt gcc ggc cgc cga 2399 Val Leu Gln Lys Tyr His Thr Glu Leu Gly Arg Val Ala Gly Arg Arg 785 790 795 gag gac tgc cgc gcc ttc ttg acc ttc act gtg gac ccc cag ggc gcc 2447 Glu Asp Cys Arg Ala Phe Leu Thr Phe Thr Val Asp Pro Gln Gly Ala 800 805 810 815 tgc aac ctc gat gat gcc ctc agt gtc cga gac ctg ggt ccc agg tgc 2495 Cys Asn Leu Asp Asp Ala Leu Ser Val Arg Asp Leu Gly Pro Arg Cys 820 825 830 gag gtg gct gtg cac atc act gat gtg gcc agc ttc gtg ccc agg gac 2543 Glu Val Ala Val His Ile Thr Asp Val Ala Ser Phe Val Pro Arg Asp 835 840 845 ggg gtg ctg gac gtg gag gcg cga agg cag ggc gct gcg ttc tat gcc 2591 Gly Val Leu Asp Val Glu Ala Arg Arg Gln Gly Ala Ala Phe Tyr Ala 850 855 860 ccc ggc agg gag cca gtg ccc atg ctg ccg gcc agc ctc tgc cag gac 2639 Pro Gly Arg Glu Pro Val Pro Met Leu Pro Ala Ser Leu Cys Gln Asp 865 870 875 gtc ctc agc ctc ctg cct ggc cgg gac cgc ctg gcc atc tcc ctg ttc 2687 Val Leu Ser Leu Leu Pro Gly Arg Asp Arg Leu Ala Ile Ser Leu Phe 880 885 890 895 ctc acc atg gag aag gcc agt ggc cag ctg aag agc ctg cgc ttt gca 2735 Leu Thr Met Glu Lys Ala Ser Gly Gln Leu Lys Ser Leu Arg Phe Ala 900 905 910 ccc tcc gtg gtc cag tct gac cgc cag ctg tcc tac gag gag gcg gag 2783 Pro Ser Val Val Gln Ser Asp Arg Gln Leu Ser Tyr Glu Glu Ala Glu 915 920 925 gag gtg atc agg cag cac ccg ggt gcc ggc cgt gag ctg ccg gcc cgc 2831 Glu Val Ile Arg Gln His Pro Gly Ala Gly Arg Glu Leu Pro Ala Arg 930 935 940 ctg gac tcc gtg gac gcc tgc gtc gtg gcc gcg tgc tac ttc tct cgg 2879 Leu Asp Ser Val Asp Ala Cys Val Val Ala Ala Cys Tyr Phe Ser Arg 945 950 955 ctg ctg cgc cgg cac cgc ctg cgg tcc gac tgc ttc tat gag cag ccg 2927 Leu Leu Arg Arg His Arg Leu Arg Ser Asp Cys Phe Tyr Glu Gln Pro 960 965 970 975 gac gag gac ggc acc ctg ggc ttc cgc gcg gcc cac atc atg gtg aag 2975 Asp Glu Asp Gly Thr Leu Gly Phe Arg Ala Ala His Ile Met Val Lys 980 985 990 gag tac atg att cag ttt aat agg ctc gtg gct gag ttc ctg gtg ggc 3023 Glu Tyr Met Ile Gln Phe Asn Arg Leu Val Ala Glu Phe Leu Val Gly 995 1000 1005 agc gag tgc acg cgg acg gtc acg cct ctg cgg tgg cag cca gca ccc 3071 Ser Glu Cys Thr Arg Thr Val Thr Pro Leu Arg Trp Gln Pro Ala Pro 1010 1015 1020 cgc agc cag cag ctc aag gcc ctg tgt gag aag cat ggg gac cgg gtg 3119 Arg Ser Gln Gln Leu Lys Ala Leu Cys Glu Lys His Gly Asp Arg Val 1025 1030 1035 ccc ctg tca ctg cac ctc ggc cac cac ctg cac ggc ggc ggg ggc agt 3167 Pro Leu Ser Leu His Leu Gly His His Leu His Gly Gly Gly Gly Ser 1040 1045 1050 1055 ccc ccc gac acg cgg ctg cac ctc ctg gcc tcc ctc tgg aag cag gtc 3215 Pro Pro Asp Thr Arg Leu His Leu Leu Ala Ser Leu Trp Lys Gln Val 1060 1065 1070 cag ttt gct gcc cgc acc cag gac tac gaa cag atg gtg gac ttg gtc 3263 Gln Phe Ala Ala Arg Thr Gln Asp Tyr Glu Gln Met Val Asp Leu Val 1075 1080 1085 acc acg gac gac atg cac cca ttc ctg gct cct gca ggc cgc gac ctc 3311 Thr Thr Asp Asp Met His Pro Phe Leu Ala Pro Ala Gly Arg Asp Leu 1090 1095 1100 cgc aag gcc ctg gag cgc tcg gcg ttc ggc cgc tgc gcc cgg ggc cac 3359 Arg Lys Ala Leu Glu Arg Ser Ala Phe Gly Arg Cys Ala Arg Gly His 1105 1110 1115 cag cag cag ggc ggc cac tac tcg ctg cag gtg gac tgg tac acg tgg 3407 Gln Gln Gln Gly Gly His Tyr Ser Leu Gln Val Asp Trp Tyr Thr Trp 1120 1125 1130 1135 gcc acc tcg ccc atc cgc agg tac ctg gac gtg gtg ttg cag cgg cag 3455 Ala Thr Ser Pro Ile Arg Arg Tyr Leu Asp Val Val Leu Gln Arg Gln 1140 1145 1150 atc ctg ctg gcg ctg ggc cat ggg ggc tct gcc tac tct gcc agg gac 3503 Ile Leu Leu Ala Leu Gly His Gly Gly Ser Ala Tyr Ser Ala Arg Asp 1155 1160 1165 atc gat ggg ctc tgc cag gcc ttc agc ctc cag cac gca ctt gcc cag 3551 Ile Asp Gly Leu Cys Gln Ala Phe Ser Leu Gln His Ala Leu Ala Gln 1170 1175 1180 agc tat cag cgg cgg gcg cgc agc ctg cac ctg gcc gtg cag ctc aag 3599 Ser Tyr Gln Arg Arg Ala Arg Ser Leu His Leu Ala Val Gln Leu Lys 1185 1190 1195 gcc cag cct ctg gac aag ctg ggc ttc gtg gtg gac gtg gag gcg ggc 3647 Ala Gln Pro Leu Asp Lys Leu Gly Phe Val Val Asp Val Glu Ala Gly 1200 1205 1210 1215 tcc cgc tgc ttc cgg ctg ctc ttc ccc agc aac cgg gag acg ctg cct 3695 Ser Arg Cys Phe Arg Leu Leu Phe Pro Ser Asn Arg Glu Thr Leu Pro 1220 1225 1230 gac ccc tgc ccc gtc ccc tac ggc tcc ctg cag ctg gcc gag cac ccc 3743 Asp Pro Cys Pro Val Pro Tyr Gly Ser Leu Gln Leu Ala Glu His Pro 1235 1240 1245 cac gcc ctg gca ggc cgg ccg ggc ctg cgg ctc ctg tgg cgg cgc cgt 3791 His Ala Leu Ala Gly Arg Pro Gly Leu Arg Leu Leu Trp Arg Arg Arg 1250 1255 1260 gtc tac tca gcg cag gga tcc agc ccg ccc ctg cca ctg cct ggc act 3839 Val Tyr Ser Ala Gln Gly Ser Ser Pro Pro Leu Pro Leu Pro Gly Thr 1265 1270 1275 gtg ccg gac cca cac acc ctg gcc gtg gag acg gcc ctg tgg aag cag 3887 Val Pro Asp Pro His Thr Leu Ala Val Glu Thr Ala Leu Trp Lys Gln 1280 1285 1290 1295 ctg ctg gag ctg gtg gag ctg cag cgc tgg ccg gag gcg gct gct ctc 3935 Leu Leu Glu Leu Val Glu Leu Gln Arg Trp Pro Glu Ala Ala Ala Leu 1300 1305 1310 atc cag gag aag ggc gag gcg tcc cag cgg cgg gag ctg gtg cag gtg 3983 Ile Gln Glu Lys Gly Glu Ala Ser Gln Arg Arg Glu Leu Val Gln Val 1315 1320 1325 cag cgg agc cac tgt ggc cat ttc ctg gag gtg gcc cgg gag ctg ggc 4031 Gln Arg Ser His Cys Gly His Phe Leu Glu Val Ala Arg Glu Leu Gly 1330 1335 1340 agt ggg gac acc ctg cag gtg cag ctc ggc acc agc ctg cag cac ggc 4079 Ser Gly Asp Thr Leu Gln Val Gln Leu Gly Thr Ser Leu Gln His Gly 1345 1350 1355 ttc ctg gta ccg agc cct cag ctc tgg acg gtg gca ccg ggc ttc agc 4127 Phe Leu Val Pro Ser Pro Gln Leu Trp Thr Val Ala Pro Gly Phe Ser 1360 1365 1370 1375 ctc tgc ctg gag cac gtg gag cgg ccc gga gac tgc ttc tca ggc cgt 4175 Leu Cys Leu Glu His Val Glu Arg Pro Gly Asp Cys Phe Ser Gly Arg 1380 1385 1390 gtg tac cgg gcc ccg agg gac cgg tac cgc gac gtg gat gag tac gcc 4223 Val Tyr Arg Ala Pro Arg Asp Arg Tyr Arg Asp Val Asp Glu Tyr Ala 1395 1400 1405 tgc gtg tgg gaa cca ttc tgc gcc ctg gag tcg gcc acc ggc gcg gtt 4271 Cys Val Trp Glu Pro Phe Cys Ala Leu Glu Ser Ala Thr Gly Ala Val 1410 1415 1420 gcc gag aat gac tcc gtc aca ctt cag cac ctg agt gtc tcc tgg gag 4319 Ala Glu Asn Asp Ser Val Thr Leu Gln His Leu Ser Val Ser Trp Glu 1425 1430 1435 gcg tca cgg acg ccg cag ggg cag ctg cag ggc gcc ttc cgc ctg gag 4367 Ala Ser Arg Thr Pro Gln Gly Gln Leu Gln Gly Ala Phe Arg Leu Glu 1440 1445 1450 1455 gcc gcc ttc ctc gag gag aac tgt gcc gac atc aac ttc agc tgc tgc 4415 Ala Ala Phe Leu Glu Glu Asn Cys Ala Asp Ile Asn Phe Ser Cys Cys 1460 1465 1470 tac ctc tgc atc cgg ctc gag ggg ctg ctg gct ccc acg gcc agc cca 4463 Tyr Leu Cys Ile Arg Leu Glu Gly Leu Leu Ala Pro Thr Ala Ser Pro 1475 1480 1485 cgc ccc ggg ccc agc agc ctc ggc cct ggc ctg aat gtt gac ccc ggc 4511 Arg Pro Gly Pro Ser Ser Leu Gly Pro Gly Leu Asn Val Asp Pro Gly 1490 1495 1500 acg tat acc tgg gtg gcc cac ggg cag acg gag gac tgg gac cag gag 4559 Thr Tyr Thr Trp Val Ala His Gly Gln Thr Glu Asp Trp Asp Gln Glu 1505 1510 1515 cgc cgg gca gac cgg cag gag gct ccc aga cgg gtg cac ctc ttc gtc 4607 Arg Arg Ala Asp Arg Gln Glu Ala Pro Arg Arg Val His Leu Phe Val 1520 1525 1530 1535 cac cac atg ggc atg gag aag gtt ccg gaa gag gtg ctg agg ccg ggc 4655 His His Met Gly Met Glu Lys Val Pro Glu Glu Val Leu Arg Pro Gly 1540 1545 1550 acc ctg ttc acc gtt gag ctg ctg ccc aag cag ctt cct gat ctc cgc 4703 Thr Leu Phe Thr Val Glu Leu Leu Pro Lys Gln Leu Pro Asp Leu Arg 1555 1560 1565 aag gag gaa gcc gtg cgt gga cta gag gag gcg tcc ccg ctg gtc acc 4751 Lys Glu Glu Ala Val Arg Gly Leu Glu Glu Ala Ser Pro Leu Val Thr 1570 1575 1580 agc atc gca ctg ggc cgg cct gtc ccg cag ccc ctc tgc aga gtg atc 4799 Ser Ile Ala Leu Gly Arg Pro Val Pro Gln Pro Leu Cys Arg Val Ile 1585 1590 1595 ccc agc agg ttc ctg gag cgg cag acc tac aac atc ccc gga ggc cgc 4847 Pro Ser Arg Phe Leu Glu Arg Gln Thr Tyr Asn Ile Pro Gly Gly Arg 1600 1605 1610 1615 cac aag ctg aac ccc agc cag aac gtg gcg gtc agg gag gct ctg gag 4895 His Lys Leu Asn Pro Ser Gln Asn Val Ala Val Arg Glu Ala Leu Glu 1620 1625 1630 aag cct ttc acg gtc att cag ggc cca cca ggt aca ggg aag acg atc 4943 Lys Pro Phe Thr Val Ile Gln Gly Pro Pro Gly Thr Gly Lys Thr Ile 1635 1640 1645 gtg ggc ctc cac atc gta ttc tgg ttt cat aaa tca aac cag gag cag 4991 Val Gly Leu His Ile Val Phe Trp Phe His Lys Ser Asn Gln Glu Gln 1650 1655 1660 gtg cag ccc gga ggc ccc ccc cgt ggg gag aag cgg ctg ggg ggt ccc 5039 Val Gln Pro Gly Gly Pro Pro Arg Gly Glu Lys Arg Leu Gly Gly Pro 1665 1670 1675 tgc atc ttg tac tgc ggc ccc tcc aac aag tcg gtg gat gtc ctg gca 5087 Cys Ile Leu Tyr Cys Gly Pro Ser Asn Lys Ser Val Asp Val Leu Ala 1680 1685 1690 1695 gga ctg ctc ctg aga agg atg gag ctg aag ccc ctc cgt gtg tac agt 5135 Gly Leu Leu Leu Arg Arg Met Glu Leu Lys Pro Leu Arg Val Tyr Ser 1700 1705 1710 gag cag gct gag gcc agc gag ttc cca gtg ccg cgt gtg ggc agc agg 5183 Glu Gln Ala Glu Ala Ser Glu Phe Pro Val Pro Arg Val Gly Ser Arg 1715 1720 1725 aag ctg ctc agg aag agc ccc cgg gag ggg agg ccg aac cag agc ctc 5231 Lys Leu Leu Arg Lys Ser Pro Arg Glu Gly Arg Pro Asn Gln Ser Leu 1730 1735 1740 agg agc atc acc ctg cac cac cgg atc cgg cag gcc ccc aac cct tac 5279 Arg Ser Ile Thr Leu His His Arg Ile Arg Gln Ala Pro Asn Pro Tyr 1745 1750 1755 tcg tcg gaa atc aag gcc ttt gac acc cgg ctg cag aga ggg gag ctc 5327 Ser Ser Glu Ile Lys Ala Phe Asp Thr Arg Leu Gln Arg Gly Glu Leu 1760 1765 1770 1775 ttc tcc agg gag gac ctg gtc tgg tac aag aag gtc ttg tgg gag gct 5375 Phe Ser Arg Glu Asp Leu Val Trp Tyr Lys Lys Val Leu Trp Glu Ala 1780 1785 1790 cgg aag ttc gag ctg gac cgg cat gag gtc atc ctc tgc acc tgc tcc 5423 Arg Lys Phe Glu Leu Asp Arg His Glu Val Ile Leu Cys Thr Cys Ser 1795 1800 1805 tgt gca gcc tct gcc agc ctc aaa atc ctg gac gtg agg cag atc ctt 5471 Cys Ala Ala Ser Ala Ser Leu Lys Ile Leu Asp Val Arg Gln Ile Leu 1810 1815 1820 gtt gac gag gca ggc atg gcc acg gaa cct gaa acc ctc atc ccc ctg 5519 Val Asp Glu Ala Gly Met Ala Thr Glu Pro Glu Thr Leu Ile Pro Leu 1825 1830 1835 gtg cag ttc cca cag gcc gag aag gtg gtt ctt ctc gga gac cac aag 5567 Val Gln Phe Pro Gln Ala Glu Lys Val Val Leu Leu Gly Asp His Lys 1840 1845 1850 1855 cag ctg cgg cct gtg gtc aag aat gag cgg ctg caa aac ctg ggt ctg 5615 Gln Leu Arg Pro Val Val Lys Asn Glu Arg Leu Gln Asn Leu Gly Leu 1860 1865 1870 gac cgg tct ctg ttc gag cgg tac cac gag gac gca cat atg ctg gac 5663 Asp Arg Ser Leu Phe Glu Arg Tyr His Glu Asp Ala His Met Leu Asp 1875 1880 1885 act cag tac cgc atg cat gag ggc atc tgt gcc ttc ccc tct gtg gcg 5711 Thr Gln Tyr Arg Met His Glu Gly Ile Cys Ala Phe Pro Ser Val Ala 1890 1895 1900 ttc tac aag agc aag ctg aag acg tgg cag ggc ctg agg agg ccg ccc 5759 Phe Tyr Lys Ser Lys Leu Lys Thr Trp Gln Gly Leu Arg Arg Pro Pro 1905 1910 1915 agt gtc ctg ggc cac gct ggc aag gag agc tgt cct gtc atc ttt ggc 5807 Ser Val Leu Gly His Ala Gly Lys Glu Ser Cys Pro Val Ile Phe Gly 1920 1925 1930 1935 cac gtg cag ggc cac gag cgg agc ctg ctg gtg tcc acg gac gaa ggg 5855 His Val Gln Gly His Glu Arg Ser Leu Leu Val Ser Thr Asp Glu Gly 1940 1945 1950 aat gag aac tcc aag gcc aac ctg gag gag gtg gct gag gtg gtc cgt 5903 Asn Glu Asn Ser Lys Ala Asn Leu Glu Glu Val Ala Glu Val Val Arg 1955 1960 1965 atc acc aag cag ctg acc ctg ggg agg acc gta gag ccc cag gac atc 5951 Ile Thr Lys Gln Leu Thr Leu Gly Arg Thr Val Glu Pro Gln Asp Ile 1970 1975 1980 gcc gtc ctc acg ccc tac aac gcg cag gcc tct gag atc agc aag gcc 5999 Ala Val Leu Thr Pro Tyr Asn Ala Gln Ala Ser Glu Ile Ser Lys Ala 1985 1990 1995 ctt cgg cga gag ggc atc gcc ggg gtg gcc gtg tcc tcc atc acc aag 6047 Leu Arg Arg Glu Gly Ile Ala Gly Val Ala Val Ser Ser Ile Thr Lys 2000 2005 2010 2015 agc cag ggg agc gag tgg cgc tat gtg ctg gtg agc acc gtc cgc acc 6095 Ser Gln Gly Ser Glu Trp Arg Tyr Val Leu Val Ser Thr Val Arg Thr 2020 2025 2030 tgt gcc aag agc gac ctg gac cag cgg ccc acc aag agc tgg ctc aag 6143 Cys Ala Lys Ser Asp Leu Asp Gln Arg Pro Thr Lys Ser Trp Leu Lys 2035 2040 2045 aag ttt ctg ggc ttc gtt gtg gac ccc aac caa gtg aac gtg gct gtc 6191 Lys Phe Leu Gly Phe Val Val Asp Pro Asn Gln Val Asn Val Ala Val 2050 2055 2060 acg cgg gcc cag gag ggg ctc tgc ctg atc gga gac cac ctc ctt ctg 6239 Thr Arg Ala Gln Glu Gly Leu Cys Leu Ile Gly Asp His Leu Leu Leu 2065 2070 2075 cgc tgc tgc ccc ctc tgg cgt agc ctc ctg gac ttc tgc gag gct cag 6287 Arg Cys Cys Pro Leu Trp Arg Ser Leu Leu Asp Phe Cys Glu Ala Gln 2080 2085 2090 2095 cag acc ctc gtg cct gcc ggc cag gtg cgc gtc tgc agg agg cca act 6335 Gln Thr Leu Val Pro Ala Gly Gln Val Arg Val Cys Arg Arg Pro Thr 2100 2105 2110 atg cct tcc tgaagagccc tctccacctg caaggtgcca ggactgggag 6384 Met Pro Ser ggaaagtcca gggccccccc accctcccca ccaccctccg ccatcagcct gcctgggcca 6444 gcctgcctcc tggcctcagg atctccctgg ggcaggaagt gggtggactt ggaggaggaa 6504 cggcaagggc cggtccccac actcttgctt ctcctgggca tctggggaca ggaacacctc 6564 tcagggtggc caagaggggc ttccttggga ccagtgtaag gaagttctgc tgtccctggg 6624 aagtctcaga accaggaagg aaaccctgtg gaggctgccc tttgaccttt ggacgccacc 6684 tgtaatcact ctggatggtg tctgtggagt tcaggtttat tttctattta aatgaactaa 6744 aagccagcat cctgccgggc gtggtggctc acgcccataa tccagcactt tgggaagccg 6804 aggcgggcag atcacctgag gtcaggagtt cgagaccatc ctggccaaca tggtgaaacc 6864 ccgtctccac taaaaataca aaattagctg ggcgtggtgg cgggcgcctg taatcccagc 6924 tacttgggag gctgaggcag gagaatcgct tgactccagg aggcgcaggc tgcagtgagc 6984 tctgatggta ccactgcact ccagcctggg tgacagagcg agaccctgtc ttaaaaaaaa 7044 aaaaacaaaa caaaaccagc atctgttact ggaacagaga cctcagccca agctcaggac 7104 aaggaggcct ccctgggaga gggggccttt ctcccaccat caccgcctgt gtccttcagg 7164 ggctgctgga gggcagccca aagccagggg cccaccccgc cccaccccac cccaccccac 7224 cctctgaaat gtgaaaagcc tgcactcttc ctgtgggctg cgcagtgggc tcgggggttg 7284 gggggtgccg gggcgatgct tccaccctgg actgagtgtt cggggcagcc tgctcggctg 7344 tatgtttctc gcacgctcac ccgcttcagt gcggctctgt ccctgctgcc gcctccagtc 7404 ctgagggagg ggcttgcccc accttctaca ttccaatttt tatatctttg aattatgtga 7464 ttagatatta atttaatgat 7484 <210> 2 <211> 4396 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (257)..(1888) <400> 2 cccattttcc tctccgccct ggcgcaccca gcctcagccc tgcttcctgt ggacgtcagg 60 cagtgatgct cttgccctca ggcctagata aaggtagggt aggcaaggcc cagccactga 120 gctcacagaa ggcagcacca ggcatccaga ctggcggggg cacaaggtat ggtgcccagc 180 atacaacact gctttgtaca tggctatgaa ggaaatgttt gtgaaattta actgaatttt 240 tttaaaagat taggca atg gac agt aga tat ctc cag ctc cag ctt tac ctg 292 Met Asp Ser Arg Tyr Leu Gln Leu Gln Leu Tyr Leu 1 5 10 ccc tct tgt tct ctc ctc caa ggt agc ggg gac tca tct ctg gag aag 340 Pro Ser Cys Ser Leu Leu Gln Gly Ser Gly Asp Ser Ser Leu Glu Lys 15 20 25 gag ttc ctc ggg gcc cca gtg ggg ccc tcg gtg agc acc ccc aac agc 388 Glu Phe Leu Gly Ala Pro Val Gly Pro Ser Val Ser Thr Pro Asn Ser 30 35 40 cag cac tct tct cct agc cgc tca ctc agt gcc aac tcc atc aag gtg 436 Gln His Ser Ser Pro Ser Arg Ser Leu Ser Ala Asn Ser Ile Lys Val 45 50 55 60 gag atg tac agc gat gag gag tca agc aga ctg ctg ggg cca gat gag 484 Glu Met Tyr Ser Asp Glu Glu Ser Ser Arg Leu Leu Gly Pro Asp Glu 65 70 75 cgg ctc ctg gaa aag gac gac agc gtg att gtg gaa gat tca ttg tct 532 Arg Leu Leu Glu Lys Asp Asp Ser Val Ile Val Glu Asp Ser Leu Ser 80 85 90 gag ccc ctg ggc tac tgt gat ggg agt ggg cca gag cct cac tcc cct 580 Glu Pro Leu Gly Tyr Cys Asp Gly Ser Gly Pro Glu Pro His Ser Pro 95 100 105 ggg ggc atc cgg ctg ccc aat ggc aag ctc aag tgt gac gtc tgc ggc 628 Gly Gly Ile Arg Leu Pro Asn Gly Lys Leu Lys Cys Asp Val Cys Gly 110 115 120 atg gtc tgt att gga ccc aac gtg ctc atg gtg cac aag cgc agt cac 676 Met Val Cys Ile Gly Pro Asn Val Leu Met Val His Lys Arg Ser His 125 130 135 140 act ggt gaa agg ccc ttc cat tgc aac cag tgt ggt gcc tcc ttc acc 724 Thr Gly Glu Arg Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr 145 150 155 cag aag ggg aac ctg ctg cgc cac atc aag ctg cac tct ggg gag aag 772 Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys 160 165 170 ccc ttt aaa tgt ccc ttc tgc aac tat gcc tgc cgc cgg cgt gat gca 820 Pro Phe Lys Cys Pro Phe Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala 175 180 185 ctc act ggt cac ctc cgc aca cac tca gtc tcc tct ccc aca gtg ggc 868 Leu Thr Gly His Leu Arg Thr His Ser Val Ser Ser Pro Thr Val Gly 190 195 200 aag ccc tac aag tgt aac tac tgt ggc cgg agc tac aaa cag cag agt 916 Lys Pro Tyr Lys Cys Asn Tyr Cys Gly Arg Ser Tyr Lys Gln Gln Ser 205 210 215 220 acc ctg gag gag cac aag gag cgg tgc cat aac tac cta cag agt ctc 964 Thr Leu Glu Glu His Lys Glu Arg Cys His Asn Tyr Leu Gln Ser Leu 225 230 235 agc act gaa gcc caa gct ttg gct ggc caa cca ggt gac gaa ata cgt 1012 Ser Thr Glu Ala Gln Ala Leu Ala Gly Gln Pro Gly Asp Glu Ile Arg 240 245 250 gac ctg gag atg gtg cca gac tcc atg ctg cac tca tcc tct gag cgg 1060 Asp Leu Glu Met Val Pro Asp Ser Met Leu His Ser Ser Ser Glu Arg 255 260 265 cca act ttc atc gat cgt ctg gcc aat agc ctc acc aaa cgc aag cgt 1108 Pro Thr Phe Ile Asp Arg Leu Ala Asn Ser Leu Thr Lys Arg Lys Arg 270 275 280 tcc aca ccc cag aag ttt gta ggc gaa aag cag atg cgc ttc agc ctc 1156 Ser Thr Pro Gln Lys Phe Val Gly Glu Lys Gln Met Arg Phe Ser Leu 285 290 295 300 tca gac ctc ccc tat gat gtg aac tcg ggt ggc tat gaa aag gat gtg 1204 Ser Asp Leu Pro Tyr Asp Val Asn Ser Gly Gly Tyr Glu Lys Asp Val 305 310 315 gag ttg gtg gca cac cac agc cta gag cct ggc ttt gga agt tcc ctg 1252 Glu Leu Val Ala His His Ser Leu Glu Pro Gly Phe Gly Ser Ser Leu 320 325 330 gcc ttt gtg ggt gca gag cat ctg cgt ccc ctc cgc ctt cca ccc acc 1300 Ala Phe Val Gly Ala Glu His Leu Arg Pro Leu Arg Leu Pro Pro Thr 335 340 345 aat tgc atc tca gaa ctc acg cct gtc atc agc tct gtc tac acc cag 1348 Asn Cys Ile Ser Glu Leu Thr Pro Val Ile Ser Ser Val Tyr Thr Gln 350 355 360 atg cag ccc ctc cct ggt cga ctg gag ctt cca gga tcc cga gaa gca 1396 Met Gln Pro Leu Pro Gly Arg Leu Glu Leu Pro Gly Ser Arg Glu Ala 365 370 375 380 ggt gag gga cct gag gac ctg gct gat gga ggt ccc ctc ctc tac cgg 1444 Gly Glu Gly Pro Glu Asp Leu Ala Asp Gly Gly Pro Leu Leu Tyr Arg 385 390 395 ccc cga ggc ccc ctg act gac cct ggg gca tcc ccc agc aat ggc tgc 1492 Pro Arg Gly Pro Leu Thr Asp Pro Gly Ala Ser Pro Ser Asn Gly Cys 400 405 410 cag gac tcc aca gac aca gaa agc aac cac gaa gat cgg gtt gcg ggg 1540 Gln Asp Ser Thr Asp Thr Glu Ser Asn His Glu Asp Arg Val Ala Gly 415 420 425 gtg gta tcc ctc cct cag ggt ccc cca ccc cag cca cct ccc acc att 1588 Val Val Ser Leu Pro Gln Gly Pro Pro Pro Gln Pro Pro Pro Thr Ile 430 435 440 gtg gtg ggc cgg cac agt cct gcc tac gcc aaa gag gac ccc aag cca 1636 Val Val Gly Arg His Ser Pro Ala Tyr Ala Lys Glu Asp Pro Lys Pro 445 450 455 460 cag gag ggg tta ttg cgg ggc acc cca ggc ccc tcc aag gaa gtg ctt 1684 Gln Glu Gly Leu Leu Arg Gly Thr Pro Gly Pro Ser Lys Glu Val Leu 465 470 475 cgg gtg gtg ggc gag agt ggt gag cct gtg aag gcc ttc aag tgt gag 1732 Arg Val Val Gly Glu Ser Gly Glu Pro Val Lys Ala Phe Lys Cys Glu 480 485 490 cac tgc cgt atc ctc ttc ctg gac cac gtc atg ttc act atc cac atg 1780 His Cys Arg Ile Leu Phe Leu Asp His Val Met Phe Thr Ile His Met 495 500 505 ggc tgc cat ggc ttc aga gac cct ttt gag tgc aac atc tgt ggt tat 1828 Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Ile Cys Gly Tyr 510 515 520 cac agc cag gac cgg tac gaa ttc tct tcc cac att gtc cgg ggg gag 1876 His Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu 525 530 535 540 cat aag gtg ggc tagcaacctc tccctctctc ctcagtccac cactccactg 1928 His Lys Val Gly ccctgactac aggcattgat ccctgtcccc accatttccc aaggagtttt gctttgtagc 1988 cctcactact ggccacctga cctcacacct gaccctgacc cctcctcacc tattctcttc 2048 ctctatcctg accgatgtaa gcattgtgat gaaacagatc ttttgcttat gtttttcctt 2108 tttatcttct ctcatcccag catactgagt tatttattaa ttagttgatt tatttttgcc 2168 tttttaaatt ttaacttata tcagtcactt gccactcccc caccctcctg tccacaactc 2228 ctttccactt taggccaatt tttctctctt agatcttcca gcagccccag gggtaggaag 2288 ctcctcttag tactaagaga cttcaagctt cttgctttaa gtcctcaccc tttacattat 2348 ctaattcttc agttttgatg ctgatacctg cccccggccc taccttagct ctgtggcatt 2408 atatctcctc tctgggactc ttcaacctgg tactccatac ctcttgtgcc ctctcacttt 2468 aggcagcttg cactattctt gaatgaatga agaattattt cctcatttgg aagtaggagg 2528 gactgaagaa attctcccca ggcactgtgg gactgagagt cctattcccc tagtaatagg 2588 tcatattccc ctagtaatat gagttctcaa agcctacatt caggatctcc ctctaggatg 2648 tgatagatct ggtccctctc cttgaactac ccctccacac gctctagtcc cttcaaccta 2708 ccggtctatt aagtggtggc ttttctctcc ttggagtgcc ccaattttat attctcaggg 2768 gccaaggcta ggtctgcaac cctctgtctc tgacagattg ggagccacag gtgcctaatt 2828 gggaaccagg gcatgggaaa ggagtgggtc aaaattcttc tctttctcct ccacctctca 2888 aacttcttca ctatagtgac cttcctaggc tctcaggggc tccttcagtc cccatcctat 2948 gagaaactag tgggttgctg cctgatgaca aggggttgtt tcagcccctc agtcatgctg 3008 ccttctgctg ctccctccca gcaggattca ccctctcatt cccgggctcc tgggccctgt 3068 tcttaggatc agtggcaggg agaaacgggt atctcttttc tctcttctaa ttttcagtat 3128 aaccaaaaat tatcccagca tgagcacggg cacgtgccct tcaccccatt ccacccttgt 3188 tccagcaaga ctgggatggg tacaactgaa ctggggtctt cctttactac ccccttctac 3248 actcagctcc cagacacagg gtaggagggg ggactgctgg ctactgcaga gacccttggc 3308 tatttgagta acctaggatt agtgagaagg ggcagaagga gatacaactc cactgcaagt 3368 ggaggtttct ttctacaaga gttttctgcc caaggccaca gccatcccac tctctgcttc 3428 cttgagattc aaaccaaagg ctgtttttct atgtttaaag aaaaaaaaaa gtaaaaacca 3488 aacacaacac ctcacaagtt gtaactcttg gtccttctct ctctcctttt ctcttccctt 3548 ccttcccctt ccatctttct ttccacatgt cctttcctta ttggctcttt tacctcctac 3608 ttttctcact ccctatcagg gatattttgg ggggggatgg taaagggtgg gctaaggaac 3668 agaccctggg attagggcct taagggctct gagaggagtc taccttgcct tcttatggga 3728 agggagaccc taaaaaactt tctcctcttt gtcctccttt ttctccccca ctctgaggtt 3788 tccccaagag aaccagattg gcagggagaa gcattgtggg gcaattgttc ctccttgaca 3848 atgtagcaat aaatagatgc tgccaagggc agaaaatggg gaggttagct cagagcagag 3908 tagtctctag agaaaggaag aatcctcaac ggcaccctgg ggtgctagct cctttttaga 3968 atgtcagcag agctgagatt aatatctggg cttttcctga actattctgg ttattgagcc 4028 cttcctgtta gacctaccgc ctcccacctc ttctgtgtct gctgtgtatt tggtgacact 4088 tcataaggac tagtcccttc tggggtatca gagccttagg gtgcccccat ccccttcccc 4148 agtcaactgt ggcacctgta acctcccgga acatgaagga ctatgctctg aggctatact 4208 ctgtgcccat gagagcagag actggaaggg caagaccagg tgctaaggag gggagagggg 4268 gcatcctgtc tctctccaga ccatcactgc actttaacca gggtcttagg tacaaaatcc 4328 tacttttcag agccttccag ctctggaacc tcaaacatcc tcatgctctc tcccagctcc 4388 ttttgcat 4396 <210> 3 <211> 8010 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(5334) <400> 3 cag gcc cag aac tgc ctc act aag cta tac aag cta gat aag atg cag 48 Gln Ala Gln Asn Cys Leu Thr Lys Leu Tyr Lys Leu Asp Lys Met Gln 1 5 10 15 ttc cga caa acc atg agg gac tat gtg aac aag gac tct ctc aat aat 96 Phe Arg Gln Thr Met Arg Asp Tyr Val Asn Lys Asp Ser Leu Asn Asn 20 25 30 gta gtg gac ttc ttg cat gct ttg cta gga ttt tgt atg gag ccg gtc 144 Val Val Asp Phe Leu His Ala Leu Leu Gly Phe Cys Met Glu Pro Val 35 40 45 act gac aac aag gct ggg ttt gga aat aac ttc acc aca gtg gac aac 192 Thr Asp Asn Lys Ala Gly Phe Gly Asn Asn Phe Thr Thr Val Asp Asn 50 55 60 aaa tcc aca gcc caa aat gtg gaa ggc att atc gtc agc gcc atg ttt 240 Lys Ser Thr Ala Gln Asn Val Glu Gly Ile Ile Val Ser Ala Met Phe 65 70 75 80 aaa tcc ctc atc aca cgc tgc gct tca acc aca cat gaa ttg cac agc 288 Lys Ser Leu Ile Thr Arg Cys Ala Ser Thr Thr His Glu Leu His Ser 85 90 95 cct gag aat ctg gga ctg tat tgt gac att cgt cag ctg gtc cag ttt 336 Pro Glu Asn Leu Gly Leu Tyr Cys Asp Ile Arg Gln Leu Val Gln Phe 100 105 110 atc aaa gag gct cat ggg aat gtc ttc agg aga gtg gcc ctc agc gct 384 Ile Lys Glu Ala His Gly Asn Val Phe Arg Arg Val Ala Leu Ser Ala 115 120 125 ctg ctt gac agt gcc gag aag tta gca cca ggg aaa aag gtg gag gag 432 Leu Leu Asp Ser Ala Glu Lys Leu Ala Pro Gly Lys Lys Val Glu Glu 130 135 140 aat gaa cag gaa tct aag cct gca ggc agt aaa agg tca gag gcg gga 480 Asn Glu Gln Glu Ser Lys Pro Ala Gly Ser Lys Arg Ser Glu Ala Gly 145 150 155 160 agc att gtg gat aaa ggc cag gta tcc tct gca cct gag gaa tgt cgc 528 Ser Ile Val Asp Lys Gly Gln Val Ser Ser Ala Pro Glu Glu Cys Arg 165 170 175 agc ttc atg tct ggt cgc ccc tca cag act cca gag cac gat gaa caa 576 Ser Phe Met Ser Gly Arg Pro Ser Gln Thr Pro Glu His Asp Glu Gln 180 185 190 atg caa gga gcc aac ttg ggg cgg aaa gat ttc tgg cgt aag atg ttc 624 Met Gln Gly Ala Asn Leu Gly Arg Lys Asp Phe Trp Arg Lys Met Phe 195 200 205 aag tcc cag agt gca gca agt gac acc agc agc cag tct gaa cag gac 672 Lys Ser Gln Ser Ala Ala Ser Asp Thr Ser Ser Gln Ser Glu Gln Asp 210 215 220 act tca gaa tgc acg act gcc cac tca ggg acc acc tct gac cga cgt 720 Thr Ser Glu Cys Thr Thr Ala His Ser Gly Thr Thr Ser Asp Arg Arg 225 230 235 240 gcc cgc tca cga tcc cgc aga att tcc ctc cga aag aag ctt aaa ctc 768 Ala Arg Ser Arg Ser Arg Arg Ile Ser Leu Arg Lys Lys Leu Lys Leu 245 250 255 ccc ata ggt aaa agg aac tgg ctg aag aga tca tcc ctc tca ggc ctg 816 Pro Ile Gly Lys Arg Asn Trp Leu Lys Arg Ser Ser Leu Ser Gly Leu 260 265 270 gca gat ggt gtg gag gac ctc ctg gac att agc tct gtg gac cga ctc 864 Ala Asp Gly Val Glu Asp Leu Leu Asp Ile Ser Ser Val Asp Arg Leu 275 280 285 tct ttc atc agg caa agc tcc aag gtc aaa ttc act agt gct gtg aag 912 Ser Phe Ile Arg Gln Ser Ser Lys Val Lys Phe Thr Ser Ala Val Lys 290 295 300 ctt tct gaa ggt ggg cca gga agt ggc atg gaa aat gga aga gat gaa 960 Leu Ser Glu Gly Gly Pro Gly Ser Gly Met Glu Asn Gly Arg Asp Glu 305 310 315 320 gag gag aat ttc ttc aag cgt ctt ggt tgc cac agt ttt gat gat cat 1008 Glu Glu Asn Phe Phe Lys Arg Leu Gly Cys His Ser Phe Asp Asp His 325 330 335 ctc tct ccc aac caa gat ggt gga aaa agc aaa aac gtg gtg aat ctt 1056 Leu Ser Pro Asn Gln Asp Gly Gly Lys Ser Lys Asn Val Val Asn Leu 340 345 350 gga gca atc cga caa ggc atg aaa cgc ttc caa ttt ctg tta aac tgc 1104 Gly Ala Ile Arg Gln Gly Met Lys Arg Phe Gln Phe Leu Leu Asn Cys 355 360 365 tgt gag cca ggg aca att cct gat gcc tcc atc cta gca gct gcc ttg 1152 Cys Glu Pro Gly Thr Ile Pro Asp Ala Ser Ile Leu Ala Ala Ala Leu 370 375 380 gat cta gaa gcc cct gtg gtg gcc aga gca gcc ttg ttc ctg gaa tgt 1200 Asp Leu Glu Ala Pro Val Val Ala Arg Ala Ala Leu Phe Leu Glu Cys 385 390 395 400 gct cgt ttt gtt cac cgc tgc aac cgt ggc aac tgg cca gag tgg atg 1248 Ala Arg Phe Val His Arg Cys Asn Arg Gly Asn Trp Pro Glu Trp Met 405 410 415 aaa ggg cac cac gtg aac atc acc aag aaa gga ctt tcc cgg gga cgc 1296 Lys Gly His His Val Asn Ile Thr Lys Lys Gly Leu Ser Arg Gly Arg 420 425 430 tct ccc att gtg ggc aac aag cga aac cag aag ctg cag tgg aat gca 1344 Ser Pro Ile Val Gly Asn Lys Arg Asn Gln Lys Leu Gln Trp Asn Ala 435 440 445 gcc aag ctc ttc tac caa tgg gga gac gca att ggc gtc cga ttg aat 1392 Ala Lys Leu Phe Tyr Gln Trp Gly Asp Ala Ile Gly Val Arg Leu Asn 450 455 460 gag ctg tgc cac ggg gaa agt gag agc cca gcc aac ctg ctg ggt ctc 1440 Glu Leu Cys His Gly Glu Ser Glu Ser Pro Ala Asn Leu Leu Gly Leu 465 470 475 480 att tac gat gaa gag acc aag agg aga ctt aga aag gag gat gag gag 1488 Ile Tyr Asp Glu Glu Thr Lys Arg Arg Leu Arg Lys Glu Asp Glu Glu 485 490 495 gaa gac ttt tta gat gac agt act gtg aac ccc tct aaa tgc ggt tgc 1536 Glu Asp Phe Leu Asp Asp Ser Thr Val Asn Pro Ser Lys Cys Gly Cys 500 505 510 ccc ttt gcc ttg aag atg gca gca tgt cag ctt ctt ctg gag att acc 1584 Pro Phe Ala Leu Lys Met Ala Ala Cys Gln Leu Leu Leu Glu Ile Thr 515 520 525 acc ttc ctg cga gag acc ttt tct tgc ctg ccc aga cct cgc act gag 1632 Thr Phe Leu Arg Glu Thr Phe Ser Cys Leu Pro Arg Pro Arg Thr Glu 530 535 540 cct ctg gtg gac ttg gag agc tgc aga ctt cgt ttg gat ccc gag ttg 1680 Pro Leu Val Asp Leu Glu Ser Cys Arg Leu Arg Leu Asp Pro Glu Leu 545 550 555 560 gac cgg cac aga tat gag agg aag atc agc ttt gct ggg gtc ctg gac 1728 Asp Arg His Arg Tyr Glu Arg Lys Ile Ser Phe Ala Gly Val Leu Asp 565 570 575 gaa aat gaa gac tca aaa gat tct ctc cac agc agc agc cac act ctc 1776 Glu Asn Glu Asp Ser Lys Asp Ser Leu His Ser Ser Ser His Thr Leu 580 585 590 aaa tca gat gca gga gtc gag gag aag aaa gaa ggg agt cct tgg agt 1824 Lys Ser Asp Ala Gly Val Glu Glu Lys Lys Glu Gly Ser Pro Trp Ser 595 600 605 gca agc gag ccc agc att gag cca gag gga atg agt aat gcc ggc gcg 1872 Ala Ser Glu Pro Ser Ile Glu Pro Glu Gly Met Ser Asn Ala Gly Ala 610 615 620 gag gag aat tac cac aga aac atg tcg tgg ctt cat gtg atg atc ttg 1920 Glu Glu Asn Tyr His Arg Asn Met Ser Trp Leu His Val Met Ile Leu 625 630 635 640 ctg tgc aat cag cag agt ttc atc tgc act cac gtt gac tac tgc cat 1968 Leu Cys Asn Gln Gln Ser Phe Ile Cys Thr His Val Asp Tyr Cys His 645 650 655 ccc cac tgc tac ctg cac cac agc cgc tcc tgt gcc cga ctg gtc aga 2016 Pro His Cys Tyr Leu His His Ser Arg Ser Cys Ala Arg Leu Val Arg 660 665 670 gcc atc aag cta ctc tat gga gac agt gtg gac tcc ctg agg gaa agc 2064 Ala Ile Lys Leu Leu Tyr Gly Asp Ser Val Asp Ser Leu Arg Glu Ser 675 680 685 agc aac atc agc agt gtg gct ctc cgg ggc aag aaa cag aaa gaa tgc 2112 Ser Asn Ile Ser Ser Val Ala Leu Arg Gly Lys Lys Gln Lys Glu Cys 690 695 700 tca gat aag tca tgc ctg agg aca cct tct cta aag aag aga gtt tca 2160 Ser Asp Lys Ser Cys Leu Arg Thr Pro Ser Leu Lys Lys Arg Val Ser 705 710 715 720 gat gcc aat ctg gaa gga aaa aaa gat tcc gga atg ctg aag tac atc 2208 Asp Ala Asn Leu Glu Gly Lys Lys Asp Ser Gly Met Leu Lys Tyr Ile 725 730 735 aga ctt cag gtg atg agc ttg tcg cct gct ccc tta tct ctg tta atc 2256 Arg Leu Gln Val Met Ser Leu Ser Pro Ala Pro Leu Ser Leu Leu Ile 740 745 750 aag gca gca cca att ctg aca gag gag atg tac gga gac atc cag cca 2304 Lys Ala Ala Pro Ile Leu Thr Glu Glu Met Tyr Gly Asp Ile Gln Pro 755 760 765 gct gcc tgg gag ctc ctg ctc agc atg gat gag cac atg gca ggg gca 2352 Ala Ala Trp Glu Leu Leu Leu Ser Met Asp Glu His Met Ala Gly Ala 770 775 780 gca gct gcc atg ttc ctg ctg tgt gca gtg aag gtg cct gag gcc gtg 2400 Ala Ala Ala Met Phe Leu Leu Cys Ala Val Lys Val Pro Glu Ala Val 785 790 795 800 tcc gac atg ctg atg tca gag ttc cac cac ccg gag act gtg cag agg 2448 Ser Asp Met Leu Met Ser Glu Phe His His Pro Glu Thr Val Gln Arg 805 810 815 ctg aac gct gtc ctc aag ttc cac acg ctc tgg agg ttt cgc tat cag 2496 Leu Asn Ala Val Leu Lys Phe His Thr Leu Trp Arg Phe Arg Tyr Gln 820 825 830 gtc tgg ccc cgg atg gag gaa ggg gca cag cag att ttt aag att ccg 2544 Val Trp Pro Arg Met Glu Glu Gly Ala Gln Gln Ile Phe Lys Ile Pro 835 840 845 cct ccc agt atc aat ttc acc ctt ccc tcg ccg gtg ctt gga atg cca 2592 Pro Pro Ser Ile Asn Phe Thr Leu Pro Ser Pro Val Leu Gly Met Pro 850 855 860 tcc gtc cca atg ttt gac cca ccg tgg gtt cct cag tgc agc ggg agt 2640 Ser Val Pro Met Phe Asp Pro Pro Trp Val Pro Gln Cys Ser Gly Ser 865 870 875 880 gtc cag gac ccc att aat gaa gac cag tct aaa tcc ttt tca gcc cgg 2688 Val Gln Asp Pro Ile Asn Glu Asp Gln Ser Lys Ser Phe Ser Ala Arg 885 890 895 gct gtg tcc cgc tcc cat caa agg gca gaa cac atc tta aag aac ttg 2736 Ala Val Ser Arg Ser His Gln Arg Ala Glu His Ile Leu Lys Asn Leu 900 905 910 cag cag gag gaa gaa aag aaa cga ctt ggt aga gaa gcc agc ctc atc 2784 Gln Gln Glu Glu Glu Lys Lys Arg Leu Gly Arg Glu Ala Ser Leu Ile 915 920 925 act gcc atc ccc atc acc cag gag gct tgc tat gag ccc aca tgc acg 2832 Thr Ala Ile Pro Ile Thr Gln Glu Ala Cys Tyr Glu Pro Thr Cys Thr 930 935 940 ccc aac tca gaa ccg gaa gaa gaa gta gaa gaa gtc acc aat ctg gca 2880 Pro Asn Ser Glu Pro Glu Glu Glu Val Glu Glu Val Thr Asn Leu Ala 945 950 955 960 tcc cgt cga ctg tct gtg agt cca tcc tgc acc tcc agc act tcc cac 2928 Ser Arg Arg Leu Ser Val Ser Pro Ser Cys Thr Ser Ser Thr Ser His 965 970 975 agg aat tat tcc ttc cgc cgc ggg tca gtc tgg tca gtg cgt tca gcc 2976 Arg Asn Tyr Ser Phe Arg Arg Gly Ser Val Trp Ser Val Arg Ser Ala 980 985 990 gtc agt gct gaa gat gag gaa cat acc act gaa cac acg ccg aac cac 3024 Val Ser Ala Glu Asp Glu Glu His Thr Thr Glu His Thr Pro Asn His 995 1000 1005 cat gtg cct cag ccc cca caa gca gtg ttc cca gca tgc atc tgt gca 3072 His Val Pro Gln Pro Pro Gln Ala Val Phe Pro Ala Cys Ile Cys Ala 1010 1015 1020 gca gta ctt ccc att gtt cat ctg atg gag gat ggt gag gtg cgg gaa 3120 Ala Val Leu Pro Ile Val His Leu Met Glu Asp Gly Glu Val Arg Glu 1025 1030 1035 1040 gat gga gta gca gtg agt gct gtg gct caa caa gtc tta tgg aac tgt 3168 Asp Gly Val Ala Val Ser Ala Val Ala Gln Gln Val Leu Trp Asn Cys 1045 1050 1055 cta att gaa gat cca tca acg gtt ctt cga cat ttt ctg gaa aaa ctg 3216 Leu Ile Glu Asp Pro Ser Thr Val Leu Arg His Phe Leu Glu Lys Leu 1060 1065 1070 acc atc agc aat aga caa gat gag tta atg tac atg ctg cgc aaa ctt 3264 Thr Ile Ser Asn Arg Gln Asp Glu Leu Met Tyr Met Leu Arg Lys Leu 1075 1080 1085 ctc ttg aat att gga gac ttt cct gct cag aca tct cac atc cta ttc 3312 Leu Leu Asn Ile Gly Asp Phe Pro Ala Gln Thr Ser His Ile Leu Phe 1090 1095 1100 aac tat ttg gta gga tta atc atg tac ttt gtg cgg acc ccc tgc gag 3360 Asn Tyr Leu Val Gly Leu Ile Met Tyr Phe Val Arg Thr Pro Cys Glu 1105 1110 1115 1120 tgg ggg atg gat gcc att tca gcc acc ctg aca ttc ctg tgg gag gtg 3408 Trp Gly Met Asp Ala Ile Ser Ala Thr Leu Thr Phe Leu Trp Glu Val 1125 1130 1135 gtg ggt tac gtg gag ggc ctc ttc ttc aag gat ctc aag cag acg atg 3456 Val Gly Tyr Val Glu Gly Leu Phe Phe Lys Asp Leu Lys Gln Thr Met 1140 1145 1150 aag aag gag cag tgt gag gtg aag ctc ctg gtg acc gct tca atg cca 3504 Lys Lys Glu Gln Cys Glu Val Lys Leu Leu Val Thr Ala Ser Met Pro 1155 1160 1165 ggt act aaa acc ttg gta gtt cat gga cag aat gag tgc gat atc cca 3552 Gly Thr Lys Thr Leu Val Val His Gly Gln Asn Glu Cys Asp Ile Pro 1170 1175 1180 acc cag tta cca gtc cat gaa gac act caa ttt gaa gcc ctg ttg aag 3600 Thr Gln Leu Pro Val His Glu Asp Thr Gln Phe Glu Ala Leu Leu Lys 1185 1190 1195 1200 gag tgt ctg gag ttt ttt aat atc cca gaa tcc cag tca aca cat tat 3648 Glu Cys Leu Glu Phe Phe Asn Ile Pro Glu Ser Gln Ser Thr His Tyr 1205 1210 1215 ttt ctt atg gat aaa cga tgg aac ctt atc cac tac aat aag acc tat 3696 Phe Leu Met Asp Lys Arg Trp Asn Leu Ile His Tyr Asn Lys Thr Tyr 1220 1225 1230 gtt cga gat att tat cct ttc cgg agg tca gta tct ccc cag ctg aat 3744 Val Arg Asp Ile Tyr Pro Phe Arg Arg Ser Val Ser Pro Gln Leu Asn 1235 1240 1245 ctt gta cat atg cat cca gag aag gga cag gag ctc att cag aaa cag 3792 Leu Val His Met His Pro Glu Lys Gly Gln Glu Leu Ile Gln Lys Gln 1250 1255 1260 gtg ttc acc cga aag ctg gaa gaa gta ggg cgg gtg ttg ttt ctc atc 3840 Val Phe Thr Arg Lys Leu Glu Glu Val Gly Arg Val Leu Phe Leu Ile 1265 1270 1275 1280 tcc cta acc cag aag atc ccc aca gcc cac aaa cag tcc cac gtc tcc 3888 Ser Leu Thr Gln Lys Ile Pro Thr Ala His Lys Gln Ser His Val Ser 1285 1290 1295 atg ctt cag gaa gac ctc ctc cgc ctg ccc tca ttc cct cgt agt gct 3936 Met Leu Gln Glu Asp Leu Leu Arg Leu Pro Ser Phe Pro Arg Ser Ala 1300 1305 1310 att gat gct gag ttt tca ctc ttc agt gat cct caa gct gga aag gaa 3984 Ile Asp Ala Glu Phe Ser Leu Phe Ser Asp Pro Gln Ala Gly Lys Glu 1315 1320 1325 ctg ttt ggc ctc gac act ctt cag aaa agc ttg tgg atc cag ctg ctg 4032 Leu Phe Gly Leu Asp Thr Leu Gln Lys Ser Leu Trp Ile Gln Leu Leu 1330 1335 1340 gag gaa atg ttc ctg ggc atg ccg agc gag ttt cca tgg gga gac gaa 4080 Glu Glu Met Phe Leu Gly Met Pro Ser Glu Phe Pro Trp Gly Asp Glu 1345 1350 1355 1360 atc atg ctt ttc ctc aac gtt ttt aac ggg gct ctg atc ctc cac ccg 4128 Ile Met Leu Phe Leu Asn Val Phe Asn Gly Ala Leu Ile Leu His Pro 1365 1370 1375 gaa gac agt gcc ctg ctc agg cag tat gct gcc acc gtc atc aac acc 4176 Glu Asp Ser Ala Leu Leu Arg Gln Tyr Ala Ala Thr Val Ile Asn Thr 1380 1385 1390 gcg gtg cac ttc aac cac ctc ttc tct ctc agc ggc tac cag tgg att 4224 Ala Val His Phe Asn His Leu Phe Ser Leu Ser Gly Tyr Gln Trp Ile 1395 1400 1405 ctc ccc acc atg ctg cag gtg tac tcc gac tat gaa agc aat ccc cag 4272 Leu Pro Thr Met Leu Gln Val Tyr Ser Asp Tyr Glu Ser Asn Pro Gln 1410 1415 1420 ctg cgt caa gcc atc gaa ttt gcc tgt cac cag ttc tat att cta cac 4320 Leu Arg Gln Ala Ile Glu Phe Ala Cys His Gln Phe Tyr Ile Leu His 1425 1430 1435 1440 cgg aag ccc ttt gtg ctc cag ctg ttt gct agt gtg gcc cct ctc ctg 4368 Arg Lys Pro Phe Val Leu Gln Leu Phe Ala Ser Val Ala Pro Leu Leu 1445 1450 1455 gaa ttt cct gat gct gcc aat aat ggg ccc agc aaa ggt gtg tca gct 4416 Glu Phe Pro Asp Ala Ala Asn Asn Gly Pro Ser Lys Gly Val Ser Ala 1460 1465 1470 cag tgc ctg ttt gac ttg ctg cag tcc cta gag gga gag acc acc gac 4464 Gln Cys Leu Phe Asp Leu Leu Gln Ser Leu Glu Gly Glu Thr Thr Asp 1475 1480 1485 ata tta gac atc tta gag ctg gtc aaa gct gag aag cct ctc aag tca 4512 Ile Leu Asp Ile Leu Glu Leu Val Lys Ala Glu Lys Pro Leu Lys Ser 1490 1495 1500 tta gat ttc tgc tat gga aac gaa gat ctg aca ttt tct atc agt gaa 4560 Leu Asp Phe Cys Tyr Gly Asn Glu Asp Leu Thr Phe Ser Ile Ser Glu 1505 1510 1515 1520 gcc att aag ctc tgt gtc act gtg gtg gcg tat gct ccc gaa tca ttc 4608 Ala Ile Lys Leu Cys Val Thr Val Val Ala Tyr Ala Pro Glu Ser Phe 1525 1530 1535 aga agt ctt cag atg ctg atg gtc tta gaa gcc tta gtt cca tgt tac 4656 Arg Ser Leu Gln Met Leu Met Val Leu Glu Ala Leu Val Pro Cys Tyr 1540 1545 1550 cta caa aag cta aag agg cag aca tca cag gtg gag aca gta cct gct 4704 Leu Gln Lys Leu Lys Arg Gln Thr Ser Gln Val Glu Thr Val Pro Ala 1555 1560 1565 gcc cga gag gag att gcg gcc act gct gct ctt gcg acg tcc cta cag 4752 Ala Arg Glu Glu Ile Ala Ala Thr Ala Ala Leu Ala Thr Ser Leu Gln 1570 1575 1580 gcc ctt ttg tac agt gta gag gtc ctc acc agg ccc atg aca gcc cca 4800 Ala Leu Leu Tyr Ser Val Glu Val Leu Thr Arg Pro Met Thr Ala Pro 1585 1590 1595 1600 cag atg agc agg tgt gac caa ggt cat aag gga acc acc aca gcc aat 4848 Gln Met Ser Arg Cys Asp Gln Gly His Lys Gly Thr Thr Thr Ala Asn 1605 1610 1615 cac acc atg tcg tct ggg gtg aac acc agg tac cag gaa caa gga gcc 4896 His Thr Met Ser Ser Gly Val Asn Thr Arg Tyr Gln Glu Gln Gly Ala 1620 1625 1630 aaa ctg cac ttt atc agg gaa aac ctt cat tta ctg gag gaa ggg caa 4944 Lys Leu His Phe Ile Arg Glu Asn Leu His Leu Leu Glu Glu Gly Gln 1635 1640 1645 ggc att ccc aga gag gaa ctg gat gaa cga att gct cgg gaa gag ttc 4992 Gly Ile Pro Arg Glu Glu Leu Asp Glu Arg Ile Ala Arg Glu Glu Phe 1650 1655 1660 aga aga ccc cgg gag tcc tta ctg aat att tgc act gag ttc tat aag 5040 Arg Arg Pro Arg Glu Ser Leu Leu Asn Ile Cys Thr Glu Phe Tyr Lys 1665 1670 1675 1680 cac tgt ggg cca cgg ctg aag atc ttg caa aat ctg gct ggg gag cct 5088 His Cys Gly Pro Arg Leu Lys Ile Leu Gln Asn Leu Ala Gly Glu Pro 1685 1690 1695 cgg gtc att gcc ttg gaa ctg ctg gat gtg aag tct cac atg agg ttg 5136 Arg Val Ile Ala Leu Glu Leu Leu Asp Val Lys Ser His Met Arg Leu 1700 1705 1710 gca gaa att gca cac tcc ctt ctg aag ctg gca cca tat gac act cag 5184 Ala Glu Ile Ala His Ser Leu Leu Lys Leu Ala Pro Tyr Asp Thr Gln 1715 1720 1725 aca atg gag agt cgt ggg ctt cgg cgc tac atc atg gag atg cta ccc 5232 Thr Met Glu Ser Arg Gly Leu Arg Arg Tyr Ile Met Glu Met Leu Pro 1730 1735 1740 att act gac tgg aca gct gag gca gtg agg ccg gcc ctc atc ctc att 5280 Ile Thr Asp Trp Thr Ala Glu Ala Val Arg Pro Ala Leu Ile Leu Ile 1745 1750 1755 1760 tta aaa aga ttg gat aga atg ttc aac aaa att cat aag atg cct act 5328 Leu Lys Arg Leu Asp Arg Met Phe Asn Lys Ile His Lys Met Pro Thr 1765 1770 1775 ttg agg tgagaatgcc tccgagttag ctgttgctat cacaaatgtc aaagttaaga 5384 Leu Arg tttgtcattt tttaagatgg tggatcattc tggagttgaa tggatgactt gaaagttttc 5444 tttggtatat gtgcatagtt aatagggtct atgaatgcct aagtagcaaa gcctacattt 5504 tgagaaaaat aacattttct ttaaaagtat atgtgctcat cttgaaaaaa atctatccat 5564 ttcttagcta tcatgctcct catctgacac atataaaaat ttcaattagt accctttaat 5624 cccttttaaa ataagggagg gttggcctta taaatgaaac aactaatgag aaaagaaaag 5684 gaattttatg ttcaaaatac tatatttaac atagctagtt aacatattta ggtaccagtt 5744 tagagaaatt ccaagcttta caataatcgc caagcagaag cttaaaaatt cgcaggattg 5804 aaaacaaaca cctagttttc acttttttac ctaattcagt gtggtactaa atgaacacta 5864 ttaatgcttg atctttgttc agtgacctgg gaaatattaa ttggtagcct acatattagc 5924 agatgttttt gaaccactct acttagagat gtgagccgag tttggaaact gtagtgatag 5984 tgagcagata gttcaacaga ttaacactgg taaacccact tactcggaaa tttcaagttt 6044 aggttagtga gaaaattttc tgtcctttta aactaaaccc aaaaatcagt gtgactcctt 6104 cccaagaatt tatagcactt aatgttcaat tcatcagaat ttttcaggta ttagtccata 6164 atctccttca cactaatcca gctttcagga gtcattaaaa aaacaaatgg aaaagtttta 6224 ttctaataat tgattatttg tttttatatt cttttatacc gtggtgatga ctacctatac 6284 attatttcaa ggttatttat ttcaatggca tggaaatgct tgttttaaaa cactatttct 6344 ttagtgatcc caatagaaca tttgtgtcta tcagcaaatg gcttatcaaa gatttataac 6404 tgtctcacaa gggtgcgtca aaataaattc ctttcttaaa tacttcatat ctaaagacgt 6464 taaacatctc caaaaatgac ccatttatgc ttcccgaaag tagatttctg gattagtaca 6524 taggcttggt cagttatagg caattttctc gggagatagg ctatgaatat ggagttggct 6584 tggatttaaa ttcattaggt gatctcagtt caacacaaga aatgttgact gaacctgacc 6644 tgcatattac cttcagtgtc ggagatgtca catagcctca tttatgaata catttccatt 6704 tgtcattgca gattccattt cgctagaaaa tataagctta gaaagtattg ccaggaaaat 6764 ataaggaaat actgttaata tcagtaaagc ccaagctgtt tattttgggg ccacagggat 6824 gaatcagtac tagaagaatt atgaaatgga ttgactttta ttacagaaaa tcccatattc 6884 atttaattgg gttatgtata cagtaacacc atttatacta ccatagaaag tagccaaaaa 6944 atacatatca tgtcttggga ggccaagaaa gaacattgtt taaataaact attttcttct 7004 aatgtgatct tcttggcagg agttaagcta tataaatcaa attagtggta gtctggtgta 7064 aaaactgatg ggcgtgtgta atctgataaa caggtttcag aaatgtagct ggggtcagat 7124 tagttctatt gggagtaatt acccctgtga tcagttttct atgatggtag tcttaggacc 7184 ctctgtcaaa gctaaaacca gggaaattaa aatgcaaccc attcatcatc tctgtttttt 7244 cttcaataga tttagtcgag tggggcaggc ctgcctctgc tacgttttca gtatcttctt 7304 cccctcccag tatgctctgt gcttttggaa caatatgggt aaacttcatc ccagagacac 7364 atcctgtctt agatggcatc agaatcactg tctcattcac ttgtttcaga ctctccagaa 7424 gggagccaag acgctaatgg cgcctatatt gtattccagg cgacaggttg agtgggagcc 7484 tgccagcaat ttgattgaag gggtttgttt gacacttcag aggcagccaa tcatatcctt 7544 cctgcctcac cttaggtcac tgatcaatgt ctgtgtcaat ctggtgagta gccaagtggc 7604 aatcttatga aactttgcac aatgtaactc tgctattgac ttctctgaat tgaagattta 7664 caggtcaacc actttgtgcc cctatctgcc catgaaaaca gacagctcag gtgacactga 7724 aaatagtgag gtacatttca aggtggtgtg tggggagatc caggaaccca tccctacaca 7784 gaagggattt tggtgtgctg cttcccatgc actactttga caattcacct cttcaagttg 7844 cgctgagagt tgagggctgc cagttggaga gtggggtggc ggagcctgca caattggcta 7904 gaagttgagg tagtctgggg tggggaactt aaaatgcaaa gaggatattt ttctcttatg 7964 gtgcaaaatg acactatgag ttggccagtc taggatttat gtgaag 8010 <210> 4 <211> 7981 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(6168) <400> 4 cag gag ctt acc agg ctg gct tgc tct gag ctg cgg tta ctg tgt cca 48 Gln Glu Leu Thr Arg Leu Ala Cys Ser Glu Leu Arg Leu Leu Cys Pro 1 5 10 15 ggc ccc ggg ttc tca gaa ctg tca tac ata aag tac aca gaa atg aag 96 Gly Pro Gly Phe Ser Glu Leu Ser Tyr Ile Lys Tyr Thr Glu Met Lys 20 25 30 aga aaa gtc gtg aat act cac aag ctg aga ttg agt cct aat gag gaa 144 Arg Lys Val Val Asn Thr His Lys Leu Arg Leu Ser Pro Asn Glu Glu 35 40 45 gcc ttc att ttg aag gaa gat tat gaa aga agg cga aaa cta aga ttg 192 Ala Phe Ile Leu Lys Glu Asp Tyr Glu Arg Arg Arg Lys Leu Arg Leu 50 55 60 cta cag gtt cga gaa caa gaa aga gat atc gcc tta cag ata aga gaa 240 Leu Gln Val Arg Glu Gln Glu Arg Asp Ile Ala Leu Gln Ile Arg Glu 65 70 75 80 gac ata aaa cag agg aga aat caa caa ttt aca cgt ttg gca gag gag 288 Asp Ile Lys Gln Arg Arg Asn Gln Gln Phe Thr Arg Leu Ala Glu Glu 85 90 95 cta agg gca gaa tgg gaa gaa tca caa act cag aaa ata cag aac ttg 336 Leu Arg Ala Glu Trp Glu Glu Ser Gln Thr Gln Lys Ile Gln Asn Leu 100 105 110 gaa aaa ctg tat ttg gca agt tta aga agt atg gga gag gga cat cga 384 Glu Lys Leu Tyr Leu Ala Ser Leu Arg Ser Met Gly Glu Gly His Arg 115 120 125 cag gcc aaa gaa aat gaa cct gat ttg gat gct ttg gca cag cgg gca 432 Gln Ala Lys Glu Asn Glu Pro Asp Leu Asp Ala Leu Ala Gln Arg Ala 130 135 140 gca gaa agg aaa aga aaa gca gat ttg agg cat aaa gaa gcc ttg aaa 480 Ala Glu Arg Lys Arg Lys Ala Asp Leu Arg His Lys Glu Ala Leu Lys 145 150 155 160 gta cag aaa aat caa aaa gaa ata tta ctg aaa caa aaa aca tgg cat 528 Val Gln Lys Asn Gln Lys Glu Ile Leu Leu Lys Gln Lys Thr Trp His 165 170 175 ata aaa gct cga aag gaa gca ctg ctt gtg gaa aaa gag aga tca gcc 576 Ile Lys Ala Arg Lys Glu Ala Leu Leu Val Glu Lys Glu Arg Ser Ala 180 185 190 aaa att aca agt ctg cca cct cct cct cca act ctt ttt gag aac atc 624 Lys Ile Thr Ser Leu Pro Pro Pro Pro Pro Thr Leu Phe Glu Asn Ile 195 200 205 gaa gta aaa aga att tct gca gtc aaa acc aat agt tct acc tac cat 672 Glu Val Lys Arg Ile Ser Ala Val Lys Thr Asn Ser Ser Thr Tyr His 210 215 220 cat ctt cac act ttt gtg aat aga gag aca gac aca aaa cag cca gat 720 His Leu His Thr Phe Val Asn Arg Glu Thr Asp Thr Lys Gln Pro Asp 225 230 235 240 gct cgt ttg gct gct gaa gag gaa gct aaa cga ttg gaa gaa cta caa 768 Ala Arg Leu Ala Ala Glu Glu Glu Ala Lys Arg Leu Glu Glu Leu Gln 245 250 255 aaa cag gca gca caa gag aga atg gaa cgg ttt gaa aag gca cat gta 816 Lys Gln Ala Ala Gln Glu Arg Met Glu Arg Phe Glu Lys Ala His Val 260 265 270 cgg gga ttc caa gca atg aag aag atc cat ttg gct caa aat cag gag 864 Arg Gly Phe Gln Ala Met Lys Lys Ile His Leu Ala Gln Asn Gln Glu 275 280 285 aaa cta atg aaa gaa ctc aaa cag cta cag caa gag gac ctg gca cgt 912 Lys Leu Met Lys Glu Leu Lys Gln Leu Gln Gln Glu Asp Leu Ala Arg 290 295 300 agg aga cag act gta gca caa atg cca cca caa cta gtt gaa ctt cca 960 Arg Arg Gln Thr Val Ala Gln Met Pro Pro Gln Leu Val Glu Leu Pro 305 310 315 320 tac aaa cgc agt gaa atg aaa gaa gac tgg cag aga gaa ttg gaa ttt 1008 Tyr Lys Arg Ser Glu Met Lys Glu Asp Trp Gln Arg Glu Leu Glu Phe 325 330 335 gcc ttt gaa gat atg tac aat gca gac agg aag gtg aaa ggg aat ctg 1056 Ala Phe Glu Asp Met Tyr Asn Ala Asp Arg Lys Val Lys Gly Asn Leu 340 345 350 att ctg cac ctt gaa cca gag ccc ttg ccc act gtg act aat cag atc 1104 Ile Leu His Leu Glu Pro Glu Pro Leu Pro Thr Val Thr Asn Gln Ile 355 360 365 caa gat gaa gag ctg gac ctt tca atg gaa caa gaa aat ttg ggt gca 1152 Gln Asp Glu Glu Leu Asp Leu Ser Met Glu Gln Glu Asn Leu Gly Ala 370 375 380 gct gaa gac ctt cca gtg aca gaa gct gaa ata tgt tct agt gaa aca 1200 Ala Glu Asp Leu Pro Val Thr Glu Ala Glu Ile Cys Ser Ser Glu Thr 385 390 395 400 gat gtt ccc ttg gta atg aag acc caa cag att cct tca aaa gtt ctt 1248 Asp Val Pro Leu Val Met Lys Thr Gln Gln Ile Pro Ser Lys Val Leu 405 410 415 ttt aaa aaa tta tta aat aag atc cga agc caa aaa tct ctc tgg aca 1296 Phe Lys Lys Leu Leu Asn Lys Ile Arg Ser Gln Lys Ser Leu Trp Thr 420 425 430 att aaa tct atg tct gag gat gaa agt gaa atg att acg act gtt agt 1344 Ile Lys Ser Met Ser Glu Asp Glu Ser Glu Met Ile Thr Thr Val Ser 435 440 445 gaa att gag agt aaa gca cca acg gtt gag tca gga aca att gcc agc 1392 Glu Ile Glu Ser Lys Ala Pro Thr Val Glu Ser Gly Thr Ile Ala Ser 450 455 460 aaa gag aga acg tta tcc tct ggg cag gaa caa gtt gtt gaa agt gat 1440 Lys Glu Arg Thr Leu Ser Ser Gly Gln Glu Gln Val Val Glu Ser Asp 465 470 475 480 aca cta aca att gag tct gga cca ctt gct agt gaa gat aaa cca ctt 1488 Thr Leu Thr Ile Glu Ser Gly Pro Leu Ala Ser Glu Asp Lys Pro Leu 485 490 495 tcg tgt ggt aca aac tct gga aaa gaa caa gaa ata aat gag act ctg 1536 Ser Cys Gly Thr Asn Ser Gly Lys Glu Gln Glu Ile Asn Glu Thr Leu 500 505 510 cct atc aca act gta gct cag agt tca gtt cta ctt cat cct caa gaa 1584 Pro Ile Thr Thr Val Ala Gln Ser Ser Val Leu Leu His Pro Gln Glu 515 520 525 gaa gca gcc agg att aga atg tca gca agg cag aaa cac ata atg gaa 1632 Glu Ala Ala Arg Ile Arg Met Ser Ala Arg Gln Lys His Ile Met Glu 530 535 540 ata gaa gag cag aag caa aag caa ttg gaa tta ctt gaa caa att gaa 1680 Ile Glu Glu Gln Lys Gln Lys Gln Leu Glu Leu Leu Glu Gln Ile Glu 545 550 555 560 cag cag aaa tta aga tta gaa act gac tgc ttc agg gct cag ctg gaa 1728 Gln Gln Lys Leu Arg Leu Glu Thr Asp Cys Phe Arg Ala Gln Leu Glu 565 570 575 gaa gaa aaa aga aaa aaa act caa ccg act ggg gtt ggc att gct cca 1776 Glu Glu Lys Arg Lys Lys Thr Gln Pro Thr Gly Val Gly Ile Ala Pro 580 585 590 gca tca tgc cct gta att tct gat gaa gat agt cat agg cag atg att 1824 Ala Ser Cys Pro Val Ile Ser Asp Glu Asp Ser His Arg Gln Met Ile 595 600 605 cgt aac tat caa cat cag ctt tta caa caa aac agg tta cac agg cag 1872 Arg Asn Tyr Gln His Gln Leu Leu Gln Gln Asn Arg Leu His Arg Gln 610 615 620 tct gtt gaa aca gcc agg aaa caa tta ctt gaa tat caa act atg tta 1920 Ser Val Glu Thr Ala Arg Lys Gln Leu Leu Glu Tyr Gln Thr Met Leu 625 630 635 640 aaa gga agg tgc cca tcg gtg tca gct cca tca ttg ata act gat tct 1968 Lys Gly Arg Cys Pro Ser Val Ser Ala Pro Ser Leu Ile Thr Asp Ser 645 650 655 gtt ata tca gtg cca tca tgg aaa tct gag aga ccg act gct ata tca 2016 Val Ile Ser Val Pro Ser Trp Lys Ser Glu Arg Pro Thr Ala Ile Ser 660 665 670 gag cat tgg gat caa ggt cag aga ctc aag ttg agt cct aac aaa tac 2064 Glu His Trp Asp Gln Gly Gln Arg Leu Lys Leu Ser Pro Asn Lys Tyr 675 680 685 caa ccc ata caa cct ata cag acc tcc aaa tta gaa caa gat cat ttt 2112 Gln Pro Ile Gln Pro Ile Gln Thr Ser Lys Leu Glu Gln Asp His Phe 690 695 700 cag gta gcg aga caa aat cac ttt cca caa aga cag gtg gaa aca aca 2160 Gln Val Ala Arg Gln Asn His Phe Pro Gln Arg Gln Val Glu Thr Thr 705 710 715 720 gaa aca tta cgc gct tca gat att tta acc aat caa gct tta gaa tca 2208 Glu Thr Leu Arg Ala Ser Asp Ile Leu Thr Asn Gln Ala Leu Glu Ser 725 730 735 caa gaa cat cta agg caa ttc tct cag act gaa aca caa cag aga gac 2256 Gln Glu His Leu Arg Gln Phe Ser Gln Thr Glu Thr Gln Gln Arg Asp 740 745 750 tat aaa ttg gtc ccc aaa gat tct gag aca ctt tca agg gct ttg tca 2304 Tyr Lys Leu Val Pro Lys Asp Ser Glu Thr Leu Ser Arg Ala Leu Ser 755 760 765 cat gac agg cag cta ata tca cag gat gct aga aaa ata tct gaa aca 2352 His Asp Arg Gln Leu Ile Ser Gln Asp Ala Arg Lys Ile Ser Glu Thr 770 775 780 ttt ggg gca aca act ttt caa agt tta gaa tcc caa caa ttg ttc tca 2400 Phe Gly Ala Thr Thr Phe Gln Ser Leu Glu Ser Gln Gln Leu Phe Ser 785 790 795 800 gag aat agt gaa aat ata tct tac cat tta act gaa cct tct tca ttt 2448 Glu Asn Ser Glu Asn Ile Ser Tyr His Leu Thr Glu Pro Ser Ser Phe 805 810 815 gta cca ctg gta cct cag cat tct ttt agt tct ctg cct gtt aaa gtt 2496 Val Pro Leu Val Pro Gln His Ser Phe Ser Ser Leu Pro Val Lys Val 820 825 830 gag tca gga aaa att caa gaa ccc ttt tca gcc atg agc aaa agt aca 2544 Glu Ser Gly Lys Ile Gln Glu Pro Phe Ser Ala Met Ser Lys Ser Thr 835 840 845 gtt tcc aca agc cat tct ata atc agc caa atg cat gat agg cct ttg 2592 Val Ser Thr Ser His Ser Ile Ile Ser Gln Met His Asp Arg Pro Leu 850 855 860 ctg ccg tca gag aat atc aca gcc cag caa ggt aat atg aag gcc ctc 2640 Leu Pro Ser Glu Asn Ile Thr Ala Gln Gln Gly Asn Met Lys Ala Leu 865 870 875 880 caa gaa cag tta gac cta cag aag aaa gtt ctt cag gca act cag gaa 2688 Gln Glu Gln Leu Asp Leu Gln Lys Lys Val Leu Gln Ala Thr Gln Glu 885 890 895 gct cag gaa cag ttg ctt ttg tgc aaa cag aaa gaa gtg gaa cag caa 2736 Ala Gln Glu Gln Leu Leu Leu Cys Lys Gln Lys Glu Val Glu Gln Gln 900 905 910 acg ggc ctc tcg gta ttc ctt ccc ttg gta act cca gat tca tct gct 2784 Thr Gly Leu Ser Val Phe Leu Pro Leu Val Thr Pro Asp Ser Ser Ala 915 920 925 tta ttg cct tct gcc aaa gca gat ttg ggg aga atc cag gaa tct tca 2832 Leu Leu Pro Ser Ala Lys Ala Asp Leu Gly Arg Ile Gln Glu Ser Ser 930 935 940 cca acc aag aat aat att gca gtt tcc tca gac cat cat gtg atc tca 2880 Pro Thr Lys Asn Asn Ile Ala Val Ser Ser Asp His His Val Ile Ser 945 950 955 960 caa ctt cag gat aag cgt ttg agt ctt tca cag cct atc cta tca cag 2928 Gln Leu Gln Asp Lys Arg Leu Ser Leu Ser Gln Pro Ile Leu Ser Gln 965 970 975 caa aat aat ttt aaa ttt ctc caa gag cag ttg aat att cag aag gat 2976 Gln Asn Asn Phe Lys Phe Leu Gln Glu Gln Leu Asn Ile Gln Lys Asp 980 985 990 agc ctt cag gct agg cga gaa gcc cag gaa gta ttg tat gta cat aaa 3024 Ser Leu Gln Ala Arg Arg Glu Ala Gln Glu Val Leu Tyr Val His Lys 995 1000 1005 cag agt gaa ttg gat aga aga gta tgt tcc gaa cag gct gag ccc tct 3072 Gln Ser Glu Leu Asp Arg Arg Val Cys Ser Glu Gln Ala Glu Pro Ser 1010 1015 1020 ttc cca ttt cag gta gct cag cat aca ttt act tca cta cca tct gct 3120 Phe Pro Phe Gln Val Ala Gln His Thr Phe Thr Ser Leu Pro Ser Ala 1025 1030 1035 1040 gat aca aaa tct gga aaa ata cag gag caa cat tca tct aag agc gag 3168 Asp Thr Lys Ser Gly Lys Ile Gln Glu Gln His Ser Ser Lys Ser Glu 1045 1050 1055 aaa gga ctt gtt tca tgc caa tct gac atc ccc ata tct cag gat ggg 3216 Lys Gly Leu Val Ser Cys Gln Ser Asp Ile Pro Ile Ser Gln Asp Gly 1060 1065 1070 tct ttg agt ttc cta cag cag ttc cta cct cta cat gat agt ttg aag 3264 Ser Leu Ser Phe Leu Gln Gln Phe Leu Pro Leu His Asp Ser Leu Lys 1075 1080 1085 ttg ctc caa gaa cag ttg act aaa cag agg gat act ctt cag gct agg 3312 Leu Leu Gln Glu Gln Leu Thr Lys Gln Arg Asp Thr Leu Gln Ala Arg 1090 1095 1100 cat gaa gct cag gtg gaa tta ctt tta cat aga caa aga gat ttg ggg 3360 His Glu Ala Gln Val Glu Leu Leu Leu His Arg Gln Arg Asp Leu Gly 1105 1110 1115 1120 gac agt aag tct ggg ctg gtg agc tct tca tcc tca cca gtg gtt gtt 3408 Asp Ser Lys Ser Gly Leu Val Ser Ser Ser Ser Ser Pro Val Val Val 1125 1130 1135 cag cat tca gtt gct tca caa gct tct gct aaa gct gag cct agg aga 3456 Gln His Ser Val Ala Ser Gln Ala Ser Ala Lys Ala Glu Pro Arg Arg 1140 1145 1150 att cag gag ctt tat tta tct gag aag gag aat gta ggt ccc tcc tgt 3504 Ile Gln Glu Leu Tyr Leu Ser Glu Lys Glu Asn Val Gly Pro Ser Cys 1155 1160 1165 cat ttg ata atc cca aca ttt cag gat aag tct ctt agt ttt cca cag 3552 His Leu Ile Ile Pro Thr Phe Gln Asp Lys Ser Leu Ser Phe Pro Gln 1170 1175 1180 cat agc ctg gca cag caa gaa aat ttg aca ata ctc caa gaa cag tca 3600 His Ser Leu Ala Gln Gln Glu Asn Leu Thr Ile Leu Gln Glu Gln Ser 1185 1190 1195 1200 caa ata caa agg gta ata ctt ggt gct aaa gaa gga act cag gaa ttt 3648 Gln Ile Gln Arg Val Ile Leu Gly Ala Lys Glu Gly Thr Gln Glu Phe 1205 1210 1215 gta cac aca gaa agt gaa ttg gag aaa aga att tct tct gaa cag act 3696 Val His Thr Glu Ser Glu Leu Glu Lys Arg Ile Ser Ser Glu Gln Thr 1220 1225 1230 ggc acc tcc tca tcc ctt tcc cag gtg gat gaa tct gag aga ttc cag 3744 Gly Thr Ser Ser Ser Leu Ser Gln Val Asp Glu Ser Glu Arg Phe Gln 1235 1240 1245 gaa tgt ata tca atc aag agt gac agt acc att ccc tta agc cat cct 3792 Glu Cys Ile Ser Ile Lys Ser Asp Ser Thr Ile Pro Leu Ser His Pro 1250 1255 1260 aag atc cca aga tgt cag gaa aga ctt ttg aga gtt tca caa cat atg 3840 Lys Ile Pro Arg Cys Gln Glu Arg Leu Leu Arg Val Ser Gln His Met 1265 1270 1275 1280 cta cct cta caa gat aat ttg gag gaa cac caa gca tgg cta gac act 3888 Leu Pro Leu Gln Asp Asn Leu Glu Glu His Gln Ala Trp Leu Asp Thr 1285 1290 1295 gag aaa gaa gcc ttt cat ttc agc cag aaa acc caa gaa aat aca tct 3936 Glu Lys Glu Ala Phe His Phe Ser Gln Lys Thr Gln Glu Asn Thr Ser 1300 1305 1310 tct gaa caa act ggt tca tct tca ttc ata ccc cag ttg gta cag ctt 3984 Ser Glu Gln Thr Gly Ser Ser Ser Phe Ile Pro Gln Leu Val Gln Leu 1315 1320 1325 tca ttt act tcg tta gct tca gct gag tct ggc aca atc ctg gaa cct 4032 Ser Phe Thr Ser Leu Ala Ser Ala Glu Ser Gly Thr Ile Leu Glu Pro 1330 1335 1340 ctt ttt aca gag agt gaa agt aaa att ttt tca agc cac ctt cag atc 4080 Leu Phe Thr Glu Ser Glu Ser Lys Ile Phe Ser Ser His Leu Gln Ile 1345 1350 1355 1360 cca caa ttg cag gat agg ctt ttg agg ata tcg caa ctt atc cag cct 4128 Pro Gln Leu Gln Asp Arg Leu Leu Arg Ile Ser Gln Leu Ile Gln Pro 1365 1370 1375 caa caa gat aat ttg aag gca ctt caa gaa cag tta gct aca cag aga 4176 Gln Gln Asp Asn Leu Lys Ala Leu Gln Glu Gln Leu Ala Thr Gln Arg 1380 1385 1390 gaa gcc atc att cta gct aga caa gaa gct cgg gaa gaa tta ctt tta 4224 Glu Ala Ile Ile Leu Ala Arg Gln Glu Ala Arg Glu Glu Leu Leu Leu 1395 1400 1405 cat cag agt gaa tgg gag gga aga ata tct ccc gag cag gtt gac acc 4272 His Gln Ser Glu Trp Glu Gly Arg Ile Ser Pro Glu Gln Val Asp Thr 1410 1415 1420 tct tcc tta ccc cta gta cca cag cat tca ttc gcc tca tta cct ctt 4320 Ser Ser Leu Pro Leu Val Pro Gln His Ser Phe Ala Ser Leu Pro Leu 1425 1430 1435 1440 aat gaa tct gaa aga aac caa gaa cca tgt tca att aac agt gat aat 4368 Asn Glu Ser Glu Arg Asn Gln Glu Pro Cys Ser Ile Asn Ser Asp Asn 1445 1450 1455 ata gta tcc tca ggt cac tca gag ata cca aca ttg cct gat ggg ctg 4416 Ile Val Ser Ser Gly His Ser Glu Ile Pro Thr Leu Pro Asp Gly Leu 1460 1465 1470 ttg ggt tta tca cat ctt gtt tta cct caa caa gat aat ttg att gca 4464 Leu Gly Leu Ser His Leu Val Leu Pro Gln Gln Asp Asn Leu Ile Ala 1475 1480 1485 ctt gaa gaa cac ttg cat gca cag aca gat ttc ctt cct tct att gag 4512 Leu Glu Glu His Leu His Ala Gln Thr Asp Phe Leu Pro Ser Ile Glu 1490 1495 1500 aaa acc cag aaa gaa ttg gtt ttg tca aaa cca tgt aaa ttt gag gaa 4560 Lys Thr Gln Lys Glu Leu Val Leu Ser Lys Pro Cys Lys Phe Glu Glu 1505 1510 1515 1520 aag gta tct tct gag cat ttt atc cag tct cac cat ggt gat ttg cag 4608 Lys Val Ser Ser Glu His Phe Ile Gln Ser His His Gly Asp Leu Gln 1525 1530 1535 gca ctt caa cag cag tta gat aca cag aag aaa gcc att cga tct ata 4656 Ala Leu Gln Gln Gln Leu Asp Thr Gln Lys Lys Ala Ile Arg Ser Ile 1540 1545 1550 cag gaa gtc caa gaa gaa ttg ctt ttg caa aga tta agt gaa ttg gag 4704 Gln Glu Val Gln Glu Glu Leu Leu Leu Gln Arg Leu Ser Glu Leu Glu 1555 1560 1565 aaa agg gta tca tct gaa caa gtt tgc tcc tct tca ttt gta tcc cag 4752 Lys Arg Val Ser Ser Glu Gln Val Cys Ser Ser Ser Phe Val Ser Gln 1570 1575 1580 gtg cct gtt gct gac tct gaa aga acc cag aag tct ttc cca acc aaa 4800 Val Pro Val Ala Asp Ser Glu Arg Thr Gln Lys Ser Phe Pro Thr Lys 1585 1590 1595 1600 agt aat gat act ctt ccc tca agt cat cgt gag att cca aga tta cag 4848 Ser Asn Asp Thr Leu Pro Ser Ser His Arg Glu Ile Pro Arg Leu Gln 1605 1610 1615 gat aga ctt ttg agt tta tca aag cct att ctg cct cag caa gat aat 4896 Asp Arg Leu Leu Ser Leu Ser Lys Pro Ile Leu Pro Gln Gln Asp Asn 1620 1625 1630 atg aca gca caa ttg gat gca caa agg gaa gtg atg tat tct tat gag 4944 Met Thr Ala Gln Leu Asp Ala Gln Arg Glu Val Met Tyr Ser Tyr Glu 1635 1640 1645 aaa ccc cag gaa gaa ctg tct tta aac aaa caa aga aag ttg aac aaa 4992 Lys Pro Gln Glu Glu Leu Ser Leu Asn Lys Gln Arg Lys Leu Asn Lys 1650 1655 1660 agt gaa tct gct gag cat act atc ccc tct ttg ttt cta ccc aag gaa 5040 Ser Glu Ser Ala Glu His Thr Ile Pro Ser Leu Phe Leu Pro Lys Glu 1665 1670 1675 1680 aca gag cat tcg ttt att cca cta cct ttt gca gaa gct aaa cct aaa 5088 Thr Glu His Ser Phe Ile Pro Leu Pro Phe Ala Glu Ala Lys Pro Lys 1685 1690 1695 agc act tgt gaa ttg tat tca tcc cag aat gaa cat gca gcc ccc cca 5136 Ser Thr Cys Glu Leu Tyr Ser Ser Gln Asn Glu His Ala Ala Pro Pro 1700 1705 1710 agt aat cct gtg atc cca ggg ttt caa gat aga ctt ttg agt ttt tca 5184 Ser Asn Pro Val Ile Pro Gly Phe Gln Asp Arg Leu Leu Ser Phe Ser 1715 1720 1725 cag tct gtc tta act cag caa gat aac ttg gga ctt cag aaa cag ttg 5232 Gln Ser Val Leu Thr Gln Gln Asp Asn Leu Gly Leu Gln Lys Gln Leu 1730 1735 1740 gat cta caa aga gaa gtt ctg cat tat agc cag aaa gcc cag gaa aaa 5280 Asp Leu Gln Arg Glu Val Leu His Tyr Ser Gln Lys Ala Gln Glu Lys 1745 1750 1755 1760 ttg ctt gta cag aga caa aca gca ttg cag cag cag ata cag aaa cat 5328 Leu Leu Val Gln Arg Gln Thr Ala Leu Gln Gln Gln Ile Gln Lys His 1765 1770 1775 gaa gag act ttg aag gat ttc ttt aaa gac agt cag ata agt aag ccc 5376 Glu Glu Thr Leu Lys Asp Phe Phe Lys Asp Ser Gln Ile Ser Lys Pro 1780 1785 1790 aca gtt gaa aat gat tta aaa acc cag aag atg ggg cag ctc aga gac 5424 Thr Val Glu Asn Asp Leu Lys Thr Gln Lys Met Gly Gln Leu Arg Asp 1795 1800 1805 tgg ttt cct aat aca caa gac cta gca gga aat gat caa gaa aat att 5472 Trp Phe Pro Asn Thr Gln Asp Leu Ala Gly Asn Asp Gln Glu Asn Ile 1810 1815 1820 agg cat gca gat agg aac aac tct gat gat aat cat ttg gct tca gaa 5520 Arg His Ala Asp Arg Asn Asn Ser Asp Asp Asn His Leu Ala Ser Glu 1825 1830 1835 1840 gat act agt gcc aag caa agt ggt gag cat ctg gag aaa gat ctg ggg 5568 Asp Thr Ser Ala Lys Gln Ser Gly Glu His Leu Glu Lys Asp Leu Gly 1845 1850 1855 aga aga tcc tca aag cca cct gta gca aaa gtc aaa tgt ggt ttg gac 5616 Arg Arg Ser Ser Lys Pro Pro Val Ala Lys Val Lys Cys Gly Leu Asp 1860 1865 1870 tta aac cag cat gaa ctt agt gct ata caa gaa gta gag tca cca gca 5664 Leu Asn Gln His Glu Leu Ser Ala Ile Gln Glu Val Glu Ser Pro Ala 1875 1880 1885 att ggc aga act tct ata cta ggt aaa cca ggt att tat gaa gac aga 5712 Ile Gly Arg Thr Ser Ile Leu Gly Lys Pro Gly Ile Tyr Glu Asp Arg 1890 1895 1900 gac ccc ctg cga gtc tca ata agc cga gaa caa agt ttc ttt ggg agc 5760 Asp Pro Leu Arg Val Ser Ile Ser Arg Glu Gln Ser Phe Phe Gly Ser 1905 1910 1915 1920 cca ctg gcc cat gat ccg ttt agt tgt ctt caa ctg gtt ggc caa gag 5808 Pro Leu Ala His Asp Pro Phe Ser Cys Leu Gln Leu Val Gly Gln Glu 1925 1930 1935 aat gtc tgt ggt gat gac tat gat gaa gca gtt aag ctg aag gaa tct 5856 Asn Val Cys Gly Asp Asp Tyr Asp Glu Ala Val Lys Leu Lys Glu Ser 1940 1945 1950 gtt gtt gaa aat cat gca gtg tta agt tat gct gtg gag gaa gaa cat 5904 Val Val Glu Asn His Ala Val Leu Ser Tyr Ala Val Glu Glu Glu His 1955 1960 1965 gca tat ttg ggt cca act gtg aag cca gat gat aag gct aaa aca ctg 5952 Ala Tyr Leu Gly Pro Thr Val Lys Pro Asp Asp Lys Ala Lys Thr Leu 1970 1975 1980 tct tat gaa cca tta tct tca gca act gtt tcc act ggg agc ctt tta 6000 Ser Tyr Glu Pro Leu Ser Ser Ala Thr Val Ser Thr Gly Ser Leu Leu 1985 1990 1995 2000 agt tat gaa aac aca gat ttg agc ctt aca gat cca gag tca ttt tca 6048 Ser Tyr Glu Asn Thr Asp Leu Ser Leu Thr Asp Pro Glu Ser Phe Ser 2005 2010 2015 gag cac atg gat gat agc aag caa gaa tct acc acc agt aaa gaa gag 6096 Glu His Met Asp Asp Ser Lys Gln Glu Ser Thr Thr Ser Lys Glu Glu 2020 2025 2030 gaa aca aat att ata agt tcc ata gtt cct tca aca caa gat tta tca 6144 Glu Thr Asn Ile Ile Ser Ser Ile Val Pro Ser Thr Gln Asp Leu Ser 2035 2040 2045 gcg gca gaa ctc ttc aga cgt tca taaatctctg ttgcctgcag tggatgaaac 6198 Ala Ala Glu Leu Phe Arg Arg Ser 2050 2055 tacatgtggt cacacacact ttcagcaaat gatagacaag tacattaatg aagcaaattt 6258 gatacctgaa aaaacagatt tgcaagaatt ggaacacatt tttcctaatt tgcatcatca 6318 gctgtttaaa cccttagaac cacatccaga ttttgactta tcatcatcat cctctgggat 6378 ttctccagac aacagagact tttaccagag atcagattct tcatctgaaa gccactgtgc 6438 tactggatta tccaaaagta cagtttattt cacagcactg aggaggacca gcatgcattc 6498 ttctcttaac acaagtccga atcaacaacc tgacactaac ttggctcatg ttggagctca 6558 cagttttgct acagaaaata ttattggggg atctgaacaa tgttttgaac agcttcagcc 6618 agaatattct tcacaggagg agagccagca tgctgatcta ccaagtattt ttagcattga 6678 agcaagagat tcttcccaag gcatgaaaaa tcagaactat ccctctgaag aacatactga 6738 aatattacaa aacaagaaaa aaattgttca tttccagctt tctataggaa acttaagttc 6798 agtctacagt tcatctgatg aagctaatgt atttgatcag ttaaatgtac agcatagcac 6858 tccatgtggt tctaactcta gtgagtgctc aacaaaacac caactagaaa gcagaaagga 6918 aagtatgggc tttgaagaac tatcaaaaag aggggttgtt acaatgttac aaagtcaagg 6978 actcattgaa gataataaaa atgaaacctg tagggtttta gacataaatc cacaggtaga 7038 ggaaactgac tctcgattat gtgtaagaac agtggagatg ggaacttcaa ttcaggcacc 7098 atattcctta actactcaaa atgaaaaata ttttgagaat tcagctgaaa cagacattcc 7158 aaaaatcacc aaaaaactat ctcaactagg agaatcagag ctttttgcaa gttctggatc 7218 attttcatta cagagctcta taccagtctg ggaaacagaa actggccatg gtataatgga 7278 agaaccagaa cttactttaa taagcaccac tgataccagt attgctgaaa tggattttgc 7338 aaatttaacc ctagaagaga agagcgagaa tgaagcaaaa tgcttctttc aggtgagtgt 7398 gtttctgcct cttgtatcag caacagaagc ctcagattat ccagctgtat cagaactttc 7458 catagaaaaa ccaaggacag catctacaga aacccctcgc aggcttacac ctgtaccagg 7518 gagcttacaa gaagcattta taaagaggaa aaaatcattt atggagagat cccaccagag 7578 gcagaaagaa ataaggaata aaattcatgt ctctgaaaat tctcaaatca aaacagttaa 7638 agagaaacca tctataagtt catctgtgag tcgtctaaag ggcgtgaata aagtcagagc 7698 atcttttcct gaagacagaa agactacaca ggctctaagg caccaaaggg gtctaaggtt 7758 atacaatcaa ctagctgaag tgaaacaaca aaaggaagaa aaaacaaaac aagaagctta 7818 tgcccaaaac agagcaaggg caaaagaatt ccataagaaa acactagaga aacttcgagc 7878 caaaaataca tgctgacttt ctagaaatag tgtaaaggtt ttttaattgt gtatatgtag 7938 cattagacaa aattatttaa agtcaataaa ttgttattcg agg 7981 <210> 5 <211> 1936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (110)..(1360) <400> 5 cagggggcgc ggccgtggga agagacccgg agagggagga cgcggccgtg gagagggacg 60 cgggagcaag gggcggcggg aggaggagga gggcgcgcgg cgcggctga cgt ggg ccg 118 Arg Gly Pro 1 ggg tcg cgc agc ggg ctg tgg gcg gcg gcg gcg gcg cgc agc gac aga 166 Gly Ser Arg Ser Gly Leu Trp Ala Ala Ala Ala Ala Arg Ser Asp Arg 5 10 15 gcg tcc ccc ggc gag gac gag cga gca cgg cgc ccg cac ctc ccc gca 214 Ala Ser Pro Gly Glu Asp Glu Arg Ala Arg Arg Pro His Leu Pro Ala 20 25 30 35 ccg ccc gcg ctg cgc gcc cgg agg agc gac cgc cgc agt tct cga gct 262 Pro Pro Ala Leu Arg Ala Arg Arg Ser Asp Arg Arg Ser Ser Arg Ala 40 45 50 cca gct gca ttc cct ccg cgt ccg ccc cac gct tct ccc gct ccg ggc 310 Pro Ala Ala Phe Pro Pro Arg Pro Pro His Ala Ser Pro Ala Pro Gly 55 60 65 ccc gca atg gcc cag gca gtg tgg tcg cgc ctc ggc cgc atc ctc tgg 358 Pro Ala Met Ala Gln Ala Val Trp Ser Arg Leu Gly Arg Ile Leu Trp 70 75 80 ctt gcc tgc ctc ctg ccc tgg gcc ccg gca ggg gtg gcc gca ggc ctg 406 Leu Ala Cys Leu Leu Pro Trp Ala Pro Ala Gly Val Ala Ala Gly Leu 85 90 95 tat gaa ctc aat ctc acc acc gat agc cct gcc acc acg gga gcg gtg 454 Tyr Glu Leu Asn Leu Thr Thr Asp Ser Pro Ala Thr Thr Gly Ala Val 100 105 110 115 gtg acc atc tcg gcc agc ctg gtg gcc aag gac aac ggc agc ctg gcc 502 Val Thr Ile Ser Ala Ser Leu Val Ala Lys Asp Asn Gly Ser Leu Ala 120 125 130 ctg ccc gct gac gcc cac ctc tac cgc ttc cac tgg atc cac acc ccg 550 Leu Pro Ala Asp Ala His Leu Tyr Arg Phe His Trp Ile His Thr Pro 135 140 145 ctg gtg ctt act ggc aag atg gag aag ggt ctc agc tcc acc atc cgt 598 Leu Val Leu Thr Gly Lys Met Glu Lys Gly Leu Ser Ser Thr Ile Arg 150 155 160 gtt gtc ggc cac gtg ccc ggg gaa ttc ccg gtc tct gtc tgg gtc act 646 Val Val Gly His Val Pro Gly Glu Phe Pro Val Ser Val Trp Val Thr 165 170 175 gcc gct gac tgc tgg atg tgc cag cct gtg gcc agg ggc ttt gtg gtc 694 Ala Ala Asp Cys Trp Met Cys Gln Pro Val Ala Arg Gly Phe Val Val 180 185 190 195 ctc ccc atc aca gag ttc ctc gtg ggg gac ctt gtt gtc acc cag aac 742 Leu Pro Ile Thr Glu Phe Leu Val Gly Asp Leu Val Val Thr Gln Asn 200 205 210 act tcc cta ccc tgg ccc agc tcc tat ctc act aag acc gtc ctg aaa 790 Thr Ser Leu Pro Trp Pro Ser Ser Tyr Leu Thr Lys Thr Val Leu Lys 215 220 225 gtc tcc ttc ctc ctc cac gac ccg agc aac ttc ctc aag acc gcc ttg 838 Val Ser Phe Leu Leu His Asp Pro Ser Asn Phe Leu Lys Thr Ala Leu 230 235 240 ttt ctc tac agc tgg gac ttc ggg gac ggg acc cag atg gtg act gaa 886 Phe Leu Tyr Ser Trp Asp Phe Gly Asp Gly Thr Gln Met Val Thr Glu 245 250 255 gac tcc gtg gtc tat tat aac tat tcc atc atc ggg acc ttc acc gtg 934 Asp Ser Val Val Tyr Tyr Asn Tyr Ser Ile Ile Gly Thr Phe Thr Val 260 265 270 275 aag ctc aaa gtg gtg gcg gag tgg gaa gag gtg gag ccg gat gcc acg 982 Lys Leu Lys Val Val Ala Glu Trp Glu Glu Val Glu Pro Asp Ala Thr 280 285 290 agg gct gtg aag cag aag acc ggg gac ttc tcc gcc tcg ctg aag ctg 1030 Arg Ala Val Lys Gln Lys Thr Gly Asp Phe Ser Ala Ser Leu Lys Leu 295 300 305 cag gaa acc ctt cga ggc atc caa gtg ttg ggg ccc acc cta att cag 1078 Gln Glu Thr Leu Arg Gly Ile Gln Val Leu Gly Pro Thr Leu Ile Gln 310 315 320 acc ttc caa aag atg acc gtg acc ttg aac ttc ctg ggg agc cct cct 1126 Thr Phe Gln Lys Met Thr Val Thr Leu Asn Phe Leu Gly Ser Pro Pro 325 330 335 ctg act gtg tgc tgg cgt ctc aag cct gag tgc ctc ccg ctg gag gaa 1174 Leu Thr Val Cys Trp Arg Leu Lys Pro Glu Cys Leu Pro Leu Glu Glu 340 345 350 355 ggg gag tgc cac cct gtg tcc gtg gcc agc aca gcg tac aac ctg acc 1222 Gly Glu Cys His Pro Val Ser Val Ala Ser Thr Ala Tyr Asn Leu Thr 360 365 370 cac acc ttc agg gac cct ggg gac tac tgc ttc agc atc cgg gcc gag 1270 His Thr Phe Arg Asp Pro Gly Asp Tyr Cys Phe Ser Ile Arg Ala Glu 375 380 385 aat atc atc agc aag aca cac aca cac aca cag aga aat ata aac aca 1318 Asn Ile Ile Ser Lys Thr His Thr His Thr Gln Arg Asn Ile Asn Thr 390 395 400 tgc gtc aca tgg gca ttt cag atg atc agc tct gta tct ggt 1360 Cys Val Thr Trp Ala Phe Gln Met Ile Ser Ser Val Ser Gly 405 410 415 taagtcggtt gctgggatgc accctgcact agagctgaaa ggaaatttga cctccaagca 1420 gccctgacag gttctgggcc cgggccctcc ctttgtgctt tgtctctgca gttcttgcgc 1480 cctttataag gccatcctag tccctgctgg ctggcagggg gctggatggg gggcaggact 1540 aatactgagt gattgcagag tgctttataa atatcacctt attttatcga aacccatctg 1600 tgaaactttc actgaggaaa aggccttgca gcggtagaag aggttgagtc aaggccgggc 1660 gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggtg gatcacgaga 1720 tcaggagatc gagaccaccc tggctaacac ggtgaaaccc cgtctctact aaaaaaatac 1780 aaaaagttag ccgggcgtgg tggtgggtgc ctgtagtccc agctactcgg gaggctgagg 1840 caggagaatg gtgcgaaccc gggaggcgga gcttgcagtg agcccagatg gcgccactgc 1900 actccagcct gagtgacaga gcgagactct gtctcc 1936 <210> 6 <211> 2576 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (91)..(2373) <400> 6 gggggtgcac ggagaaaagg ggcggggtgg tccgggctgc tgtgctggca gcagtaggcg 60 agggcgcggc tgcggggttc ctggtgctga gga cgg acg cca ttg gag ttc ccg 114 Gly Arg Thr Pro Leu Glu Phe Pro 1 5 aga agg ctg agc tct cat ctc cct ggg acc cgc agc atg gct gag gga 162 Arg Arg Leu Ser Ser His Leu Pro Gly Thr Arg Ser Met Ala Glu Gly 10 15 20 agc ttc agc gtg caa tcg gaa agc tac agt gtt gaa gac atg gat gag 210 Ser Phe Ser Val Gln Ser Glu Ser Tyr Ser Val Glu Asp Met Asp Glu 25 30 35 40 ggt agc gac gaa gtc ggg gag gaa gag atg gtt gaa ggc aac gac tat 258 Gly Ser Asp Glu Val Gly Glu Glu Glu Met Val Glu Gly Asn Asp Tyr 45 50 55 gaa gaa ttc ggt gcg ttt ggt ggc tat ggc acc ctc acc agc ttt gac 306 Glu Glu Phe Gly Ala Phe Gly Gly Tyr Gly Thr Leu Thr Ser Phe Asp 60 65 70 atc cat atc ctc aga gcc ttc gga agc ttg ggt cca ggc ctt cgc atc 354 Ile His Ile Leu Arg Ala Phe Gly Ser Leu Gly Pro Gly Leu Arg Ile 75 80 85 tta tcg aat gag ccc tgg gaa ctg gaa aac cct gtg ctg gcc cag acc 402 Leu Ser Asn Glu Pro Trp Glu Leu Glu Asn Pro Val Leu Ala Gln Thr 90 95 100 ctg gtg gag gca ttg cag ctg gat ccg gaa aca ctt gcc aat gag acg 450 Leu Val Glu Ala Leu Gln Leu Asp Pro Glu Thr Leu Ala Asn Glu Thr 105 110 115 120 gcc gcc cgt gct gcc aac gta gcc cgc gcc gcc gcc tcc aac cgt gcg 498 Ala Ala Arg Ala Ala Asn Val Ala Arg Ala Ala Ala Ser Asn Arg Ala 125 130 135 gct cgg gcc gct gcc gcc gct gcc cgt acc gcc ttc agt cag gtg gtc 546 Ala Arg Ala Ala Ala Ala Ala Ala Arg Thr Ala Phe Ser Gln Val Val 140 145 150 gct agc cac cgg gtg gcc acg ccg cag gtc tca gga gag gat acc cag 594 Ala Ser His Arg Val Ala Thr Pro Gln Val Ser Gly Glu Asp Thr Gln 155 160 165 ccc acg acc tac gcc gcc gag gct cag ggg ccc acc cct gag cca ccc 642 Pro Thr Thr Tyr Ala Ala Glu Ala Gln Gly Pro Thr Pro Glu Pro Pro 170 175 180 ctt gct tct ccg cag acc tcc cag atg tta gtc acc agt aag atg gct 690 Leu Ala Ser Pro Gln Thr Ser Gln Met Leu Val Thr Ser Lys Met Ala 185 190 195 200 gcc ccc gag gct ccg gca acc tcc gca cag tcc cag aca ggc tcc ccg 738 Ala Pro Glu Ala Pro Ala Thr Ser Ala Gln Ser Gln Thr Gly Ser Pro 205 210 215 gcc cag gag gct gct act gag ggc cct agt agc gcc tgt gct ttc tct 786 Ala Gln Glu Ala Ala Thr Glu Gly Pro Ser Ser Ala Cys Ala Phe Ser 220 225 230 cag gct ccg tgt gcc agg gag gtg gac gcc aac cgg ccc agc aca gcc 834 Gln Ala Pro Cys Ala Arg Glu Val Asp Ala Asn Arg Pro Ser Thr Ala 235 240 245 ttc ctg ggc cag aat gat gtc ttc gat ttc act cag ccg gca ggt gtc 882 Phe Leu Gly Gln Asn Asp Val Phe Asp Phe Thr Gln Pro Ala Gly Val 250 255 260 agt ggc atg gcc ttc ccg cgc ccc aag aga cct gcc cca gcc caa gag 930 Ser Gly Met Ala Phe Pro Arg Pro Lys Arg Pro Ala Pro Ala Gln Glu 265 270 275 280 gct gcc aca gag ggc ccc agt gct gcc tct ggt gtg ccc cag acg gga 978 Ala Ala Thr Glu Gly Pro Ser Ala Ala Ser Gly Val Pro Gln Thr Gly 285 290 295 cct ggc agg gag gtg gca gcc acc cgg ccc aag acc acc aag tcg ggg 1026 Pro Gly Arg Glu Val Ala Ala Thr Arg Pro Lys Thr Thr Lys Ser Gly 300 305 310 aag gcg ctg gcc aag act cgg tgg gtg gag cct cag aat gtt gtg gca 1074 Lys Ala Leu Ala Lys Thr Arg Trp Val Glu Pro Gln Asn Val Val Ala 315 320 325 gca gct gct gcc aag gcc aag atg gcc acg agc atc cct gag ccg gag 1122 Ala Ala Ala Ala Lys Ala Lys Met Ala Thr Ser Ile Pro Glu Pro Glu 330 335 340 ggt gca gct gct gcc act gct cag cac agt gct gag ccc tgg gcc agg 1170 Gly Ala Ala Ala Ala Thr Ala Gln His Ser Ala Glu Pro Trp Ala Arg 345 350 355 360 atg gga ggc aag agg acc aag aag tcc aag cac ctg gat gat gag tat 1218 Met Gly Gly Lys Arg Thr Lys Lys Ser Lys His Leu Asp Asp Glu Tyr 365 370 375 gag agc agc gag gag gag aga gag act ccc gcg gtc cca ccc acc tgg 1266 Glu Ser Ser Glu Glu Glu Arg Glu Thr Pro Ala Val Pro Pro Thr Trp 380 385 390 aga gca tca cag ccc tca ttg acg gtg cgg gct cag ttg gcc cct cgg 1314 Arg Ala Ser Gln Pro Ser Leu Thr Val Arg Ala Gln Leu Ala Pro Arg 395 400 405 ccc ccg atg gcc ccg agg tcc cag ata ccc tca agg cac gta ctg tgc 1362 Pro Pro Met Ala Pro Arg Ser Gln Ile Pro Ser Arg His Val Leu Cys 410 415 420 ctg ccc ccc cgc aac gtg acc ctt ctg cag gag agg gca aat aag ttg 1410 Leu Pro Pro Arg Asn Val Thr Leu Leu Gln Glu Arg Ala Asn Lys Leu 425 430 435 440 gtg aaa tac ctg atg att aag gac tac aag aag atc ccc atc aag cgc 1458 Val Lys Tyr Leu Met Ile Lys Asp Tyr Lys Lys Ile Pro Ile Lys Arg 445 450 455 gca gac atg ctg aag gat gtc atc aga gaa tat gat gaa cat ttc cct 1506 Ala Asp Met Leu Lys Asp Val Ile Arg Glu Tyr Asp Glu His Phe Pro 460 465 470 gag atc att gaa cga gca acg tac acc ctg gaa aag aag ttt ggg atc 1554 Glu Ile Ile Glu Arg Ala Thr Tyr Thr Leu Glu Lys Lys Phe Gly Ile 475 480 485 cac ctg aag gag atc gac aag gaa gaa cac ctg tat att ctt gtc tgc 1602 His Leu Lys Glu Ile Asp Lys Glu Glu His Leu Tyr Ile Leu Val Cys 490 495 500 aca cgg gac tcc tca gct cgc ctc ctt gga aaa acc aag gac act ccc 1650 Thr Arg Asp Ser Ser Ala Arg Leu Leu Gly Lys Thr Lys Asp Thr Pro 505 510 515 520 agg ctg agt ctc ctc ttg gtg att ctg ggc gtc atc ttc atg aat ggc 1698 Arg Leu Ser Leu Leu Leu Val Ile Leu Gly Val Ile Phe Met Asn Gly 525 530 535 aac cgt gcc agc gag gct gtc ctc tgg gag gca cta cgc aag atg gga 1746 Asn Arg Ala Ser Glu Ala Val Leu Trp Glu Ala Leu Arg Lys Met Gly 540 545 550 ctg cgc cct ggg gtg agg cac cca ttc ctc ggc gat ctg agg aag ctc 1794 Leu Arg Pro Gly Val Arg His Pro Phe Leu Gly Asp Leu Arg Lys Leu 555 560 565 atc aca gat gac ttt gtg aag cag aag tac ctg gaa tac aag aag atc 1842 Ile Thr Asp Asp Phe Val Lys Gln Lys Tyr Leu Glu Tyr Lys Lys Ile 570 575 580 ccc aac agc aac cca cct gag tat gaa ttc ctc tgg ggc ctg cga gcc 1890 Pro Asn Ser Asn Pro Pro Glu Tyr Glu Phe Leu Trp Gly Leu Arg Ala 585 590 595 600 cgc cat gag acc agc aag atg agg gtc ctg aga ttc atc gcc cag aat 1938 Arg His Glu Thr Ser Lys Met Arg Val Leu Arg Phe Ile Ala Gln Asn 605 610 615 cag aac cga gac ccc cgg gaa tgg aag gct cat ttc ttg gag gct gtg 1986 Gln Asn Arg Asp Pro Arg Glu Trp Lys Ala His Phe Leu Glu Ala Val 620 625 630 gat gat gct ttc aag aca atg gat gtg gat atg gcc gag gaa cat gcc 2034 Asp Asp Ala Phe Lys Thr Met Asp Val Asp Met Ala Glu Glu His Ala 635 640 645 agg gcc cag atg agg gcc cag atg aat atc ggg gat gaa gcg ctg att 2082 Arg Ala Gln Met Arg Ala Gln Met Asn Ile Gly Asp Glu Ala Leu Ile 650 655 660 gga cgg tgg agc tgg gat gac ata caa gtc gag ctc ctg acc tgg gat 2130 Gly Arg Trp Ser Trp Asp Asp Ile Gln Val Glu Leu Leu Thr Trp Asp 665 670 675 680 gag gac gga gat ttt ggc gat gcc tgg gcc agg atc ccc ttt gct ttc 2178 Glu Asp Gly Asp Phe Gly Asp Ala Trp Ala Arg Ile Pro Phe Ala Phe 685 690 695 tgg gcc aga tac cat cag tac att ctg aat agc aac cgt gcc aac agg 2226 Trp Ala Arg Tyr His Gln Tyr Ile Leu Asn Ser Asn Arg Ala Asn Arg 700 705 710 agg gcc acg tgg aga gct ggc gtc agc agt ggc acc aat gga ggg gcc 2274 Arg Ala Thr Trp Arg Ala Gly Val Ser Ser Gly Thr Asn Gly Gly Ala 715 720 725 agc acc agc gtc cta gat ggc ccc agc acc agc tcc acc atc cgg acc 2322 Ser Thr Ser Val Leu Asp Gly Pro Ser Thr Ser Ser Thr Ile Arg Thr 730 735 740 aga aat gct gcc aga gct ggc gcc agc ttc ttc tcc tgg atc cag cac 2370 Arg Asn Ala Ala Arg Ala Gly Ala Ser Phe Phe Ser Trp Ile Gln His 745 750 755 760 cgt tgacgaactg cagcgatctt actggccaag ccagagcgcc tcctctcaga 2423 Arg ttccttctcg acacagcacc ctaggcggct tcttcctgtc agtcggaggt ggcatgcaag 2483 atgaagctct ctttgctctt cctgctttca ttttgtgctt ttccttgtgt tttcatgttt 2543 tgggtatcag tgttacatta aagttgcaaa att 2576 <210> 7 <211> 5515 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (211)..(1260) <400> 7 cttgctttgt cacccaggct ggagtgcaga ggcccgatct cggttcactg caacctccac 60 ctcccaggtt caagcgattc tcctgcctca gcctcccaag taaatgggat ttcaggcgtg 120 caccaccacg cccagctaat ttttgtattt ttagtagaga cggggtttca tcatgttggt 180 caggctggtc ttgaactcct gacctcgtga tcc gcc cgc ctc ggc ctc cca aag 234 Ser Ala Arg Leu Gly Leu Pro Lys 1 5 tgc tgg gat tac agg tgt ggg cca ccg cgc ccg gcc ggg aac atc ctt 282 Cys Trp Asp Tyr Arg Cys Gly Pro Pro Arg Pro Ala Gly Asn Ile Leu 10 15 20 ttc atc cgg tcc atg tct tgc ttg tgc ctt ggt ctc ttg tgg acc gac 330 Phe Ile Arg Ser Met Ser Cys Leu Cys Leu Gly Leu Leu Trp Thr Asp 25 30 35 40 agc tgc tgt ctc cct ggc cgg gtg ctg ggc cct ctg cac cca cca gcc 378 Ser Cys Cys Leu Pro Gly Arg Val Leu Gly Pro Leu His Pro Pro Ala 45 50 55 gcg ttc tcc ccg ccc cac ccc cct gca gta ccg ccc agt gac cgc gcc 426 Ala Phe Ser Pro Pro His Pro Pro Ala Val Pro Pro Ser Asp Arg Ala 60 65 70 cct gtc ccg cag acc gtg cag tcc ctc ggc ttc gcc atc tac cgc gcg 474 Pro Val Pro Gln Thr Val Gln Ser Leu Gly Phe Ala Ile Tyr Arg Ala 75 80 85 ctg gac tgg ggg ctg gac gag agc gag gag cgc gaa ctc agc cct cag 522 Leu Asp Trp Gly Leu Asp Glu Ser Glu Glu Arg Glu Leu Ser Pro Gln 90 95 100 ctg gag cgg ctc atc gac ctc atg gcc aac aac gac agc gag gac agc 570 Leu Glu Arg Leu Ile Asp Leu Met Ala Asn Asn Asp Ser Glu Asp Ser 105 110 115 120 ggc tgc ggt gcc gcc gat gag ggc tac ggg ggt ccc gag gag gag gag 618 Gly Cys Gly Ala Ala Asp Glu Gly Tyr Gly Gly Pro Glu Glu Glu Glu 125 130 135 gag gcc gag ggc gtc ccc cgc agc gtg cgc acc ttt gcc cag gcc atg 666 Glu Ala Glu Gly Val Pro Arg Ser Val Arg Thr Phe Ala Gln Ala Met 140 145 150 cgg ctg tgc gcg gcg cgg ctg acc gac ccc cgg ggc gca cag gcg cat 714 Arg Leu Cys Ala Ala Arg Leu Thr Asp Pro Arg Gly Ala Gln Ala His 155 160 165 tac cag gcc gtg tgc cgc gcg ctc ttc gtg gag acg ctg gag ctg cgg 762 Tyr Gln Ala Val Cys Arg Ala Leu Phe Val Glu Thr Leu Glu Leu Arg 170 175 180 gcc ttc ctg gcc agg gtc cgg gag gcc aag gag atg ctg cag aag ctt 810 Ala Phe Leu Ala Arg Val Arg Glu Ala Lys Glu Met Leu Gln Lys Leu 185 190 195 200 cgg gag gac gag ccg cat ctg gag acg cct cgg gca gag ctg gac agc 858 Arg Glu Asp Glu Pro His Leu Glu Thr Pro Arg Ala Glu Leu Asp Ser 205 210 215 ctg ggt cac aca gac tgg gcc cga ctg tgg gtt cag ctc atg cgg gag 906 Leu Gly His Thr Asp Trp Ala Arg Leu Trp Val Gln Leu Met Arg Glu 220 225 230 ctc cgc cgc gga gtg aag ctg aag aag gtg caa gag cag gag ttc aac 954 Leu Arg Arg Gly Val Lys Leu Lys Lys Val Gln Glu Gln Glu Phe Asn 235 240 245 ccc ctc ccc acc gag ttc cag ctc acg ccc ttc gag atg ctg atg cag 1002 Pro Leu Pro Thr Glu Phe Gln Leu Thr Pro Phe Glu Met Leu Met Gln 250 255 260 gac atc cgg gcc cgg aac tac aag ctg cgc aag gtc atg gtg gat ggg 1050 Asp Ile Arg Ala Arg Asn Tyr Lys Leu Arg Lys Val Met Val Asp Gly 265 270 275 280 gac atc ccg ccc cgg gtg gag aag gac gct cac gag ctc atc ctg gac 1098 Asp Ile Pro Pro Arg Val Glu Lys Asp Ala His Glu Leu Ile Leu Asp 285 290 295 ttt atc cgc tca cgg cct cca ctg aag cag gtg ctg ccc cag cct cct 1146 Phe Ile Arg Ser Arg Pro Pro Leu Lys Gln Val Leu Pro Gln Pro Pro 300 305 310 cct cct cag ggg ccg ccc ggg gcc tgg tgc tgt cct gta gcc agc ctg 1194 Pro Pro Gln Gly Pro Pro Gly Ala Trp Cys Cys Pro Val Ala Ser Leu 315 320 325 gga ggt gtc cca gca cgt ctt cct gtg gcc agc ctg gga ggt gtc cca 1242 Gly Gly Val Pro Ala Arg Leu Pro Val Ala Ser Leu Gly Gly Val Pro 330 335 340 gtg cgt ctg cgt cac ggg tgaggcgggc tggcttcctc ttgcctgtgt 1290 Val Arg Leu Arg His Gly 345 350 gccagcccgg ggctgtgtgg ccctgggccc tttttctggg aaggggccat gtgagccatg 1350 cccaccccac cccaggtgca tgcggagccc agagccccct gggagcagca ctccctccgg 1410 gtgggcctgg caggctcttc cgactccaga gtgggcccgt gtcatggtca cttccccacc 1470 acaggtcccg cttccccacc gcaggtcccg cttccccacc gcaggtcctg cttccccacc 1530 gcaggtctcg cttccccacc gcaggtctct gagaggcggc tgcgcccgtt gccaccaaag 1590 caaaggtccc tgcatgagaa gatcctggag gagatcaagc aggagcggag gctgcgcccg 1650 gtgcggggcg agggctgggc tgcccgcggg tttggctctc tgccctgcat cctcaacgcc 1710 tgctccggag atgccaagtc cacctcctgc atcaacctgt cagtcacaga tgctgggggc 1770 agcgcccagc gcccgcggcc ccgcgtgctg ctcaaggcgc ctaccttggc tgaaatggaa 1830 gagatgaata catctgagga agaagagtct ccgtgtgggg aggtgacgct gaaacgggac 1890 cgctccttct cagagcatga cctggcccag ctccgaagtg aggtggcctc tggcctgcag 1950 tcggccaccc accccccagg agggacggag ccaccacggc cccgagctgg cagtgcgcat 2010 gtgtggaggc ccggctcccg agaccagggt acctgtcccg cgagtgtctc tgaccccagc 2070 caccccctac tcagcaaccg gggctcctcg ggggacagac ccgaggcctc catgaccccc 2130 gatgccaaac acctgtggct ggtgagtgag ggtgcgattg tcgtccaggg cggcccaggg 2190 ggcgtctttg cacccacctt cccgccgcca gccaggtctg ggagatgggt ctgagcacct 2250 gtctgggggg tgtggcctga gcgtccgtct gggggggcgc ggtctgaaca tggggcacca 2310 gtggtggagc tgctggtctg gggccgtggt ctctgctgcc gcctgctggg gccgaaccgc 2370 actgcactgc ggccccggag cctggtccct aattgaaggg ttcagtgtgg ggttagggca 2430 gacggtgaac ctgcgtgccc tgtgcctgga ggtcagtgtg aggggggttc actgggtcga 2490 gaccttgact ctggccgtga cgccgccacg gtactgctca gcccctctgc cctcggtttc 2550 ttatctgacc tgtaattgtg aagagctcac ctttgctgac atcttgaggc ccacgtggac 2610 ctgagttctg gtgcaggatt taatcaactg aggtaagggg agtgtgcggc ccgtgggcca 2670 cggtggcagc atgcaggtgt tggagggatg tgaacggtgt ggttgctgtc actatttgag 2730 gttttatcca gcggctcaga tgagaacaga tgttaaaatg ctttgagaac tatgagcctt 2790 atataaatgc aaggcactgt gcgtatcccc accgaaacgc agggcctgcc ctgttagcct 2850 aggtcgtatc ccaccgaagg cagggcttgc cccgttagcc taggattagc tatatatcac 2910 tgcatcaaaa gttacctcaa aatgcagcat cttaaaataa caaatatata ttatctcaca 2970 gtttctgagg gttgggactc cggcagtgtc ttagctgtgt ggccatggct cagggtcttt 3030 cgtgaggctg cagttaggat ggcagtgggg cctgatctcg actgaagggt caaatcgggg 3090 ctggaggagc cgtctgaagt ggcgtcttca cccagctgtg agcaggaggc gtgagtccct 3150 tgctgtgtag gcctctctcg ggctgcttgg ggatccccac agcgtggtgg ctggcgtccc 3210 ccagagcacg tggttcaaga gtgagcgcag tgaaagccac tgagtattta tgaccaagtc 3270 cagcagtgcc acattgtccc aactcactag gaatgagtca ctaagtccag cctattctca 3330 aggggaggga gagaattaag gcccacttct tttttttttt ttttttgaga caagagtctg 3390 gctctgtcgc ccaggctgga gtgcagtggc gccatctcgg ctcactgcaa gctccgcctc 3450 ccgggttcat gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccac 3510 caccgcaccc ggctaatttt ttgtattttt agtagagacg gggtttcatc gtgttagcca 3570 ggatggtttc gatctcctga cctcatcatc cgccctcttc ggcctcccaa agtgctggga 3630 cctgacctcg tcatccgccc tcttcggcct cccaaagtgc tgggatcaca ggcgtgagcc 3690 accgcacccg gccaaggccc acttcttaag gaattagagg acacatttaa gatgaccaca 3750 ggtcacatga gtggttcttt agctctgaag tctcagaagt gctttctgaa ggggggctac 3810 tgagcaccac agaacctggc cttccatctg ccctgggctc acagcctcac ctggggagca 3870 ggcggccctt ctctgtacct ggcgtgaggt ctcctggcca cggacgttgt tggcgtcaca 3930 cctgtggcac ctgaggtgaa ttgttcagat ggaaacggca ccatcaggca actggcaaca 3990 gaagcctaaa gccctgggtg cctcaggtca gaggaaggaa ggaatgcaag ggccccgctc 4050 cccccaatgc caggagcgtg tgttcacagc tttagacagg acaacccact gcaaatccaa 4110 agcagaaaac atggtccaac tccatctctg tggcaccttc atagatggtg cccacctgcc 4170 ttggcagtga tgaccgacac tgcgaacgct gtgctggcag tgtgtttaag ggctttaact 4230 gaatcatctc gatggagctg aaatccagcc ccattttaca gaagagaaaa ctgaggctta 4290 gagagatcag gtgtcaagtt ctatgccaag cacagggaag caaaaacagg acacactcaa 4350 cataaggtgg ccccaggaat cagtggccag gacacgggag gtgtgctgag cgcagatggg 4410 cagatgcaag ctgaggtggc ctgttggagg gtcctggacc ttccagaaaa gaggacatca 4470 gctgctcagg gagggaaggt ttgagatgga ttctggctgg tgtggatcag cccatggtgt 4530 gtttgcaggc agggacacct tgaacagaca tgggctgagg ggagtttgtg tggagcgtgg 4590 ccagtgaagg ctgggctggc cggcagggtc cgctggtcat gggaggcctg gcctgcagca 4650 gcagggccca tcaaagacat ggggatggat ggctgatgga caagatggct gatggacagc 4710 gttttagaag gtcgcaggct tgtttaggct gaggccaggg agggttaggg tcctcaggga 4770 aggagagtaa gctaggggag cctcctgcat agaagacttc ctacctgagg ccgtccccta 4830 ggagttcagc caccccgtgg agagcctggc gctgactgtg gaagaggtga tggacgtgcg 4890 ccgtgtgctg gtgaaggccg agatggaaaa gtttttgcag aacaaggagc tcttcagcag 4950 tctgaagaag gggaagattt gctgctgctg ccgggccaag ttcccgctgt tctcgtggcc 5010 gcccagctgt ctcttctgca agagagccgt ctgcacttcc tgtagcataa agatgaagat 5070 gccttctaag aaatttggac acatccctgt ctacacactg ggctttgaga gtcctcagag 5130 ggtatcagct gccaaaaccg cgccaatcca gagaagagac atctttcagt ctctgcaagg 5190 gccacagtgg cagagcgtgg aggaggcgtt cccccacatc tactcccacg gctgtgtcct 5250 gaaggatgtc tgcagtgagt gcaccagctt tgtggcagac gtggtgcgtt ccagccgcaa 5310 gagcgtggac gtcctcaaca ctacgccacg acgcagtcgc cagacccaat ccctctacat 5370 ccctaacacc aggactcttg acttcaagtg acagccccag gtggccaggc ctccaggagg 5430 caccaggcag gccctgtatc aggctaggac gctctgagct gtgcatgtac atatatacat 5490 atatagatac atttataata tatac 5515 <210> 8 <211> 6103 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4704)..(5321) <400> 8 caggtgtcca agataacatt ttcgattgag gatctaggtg ggagggcaag gaaagccatt 60 ggcttgtgga aatgcagatg gcctccgctc caggacgtca cacgcccttg caccattcgg 120 gccgtttgac gacagacctg tgctagattt cagagcgagc tctcacctgc ctacgtcagc 180 ccttggtaca gtgggtcttg cagtggcttt tcagagcccc tgtgtcctgt gactgcgggg 240 agaggcgcat tgtctcctag acggagcacg gcagccgctg cgcagcacac agtcctgtgg 300 gctctggcag tggcgggacc tcttgaagct gggtggcaga tgagagatgc accatggccc 360 aggtgctctc cctggcttac ctgttgaacc tgattatttg gaaacttatt tctgcagagc 420 cttggatttc aaattggaaa tatgtcctat attctaactt ctgattcctt tttcaagcct 480 cagtttgccc atttccacct taagttaata gtgctctcat tctgatgtac gatgcaggaa 540 catgtttgcc gtggtgagaa agaaaggggt tctttaaaaa tgtgctggtt agagccagtg 600 tttccagctg tttacctata taagtcaaaa tccagtgtct atatagtcac ttaccatttc 660 agttctatga aacaataaaa tacagtacag ggtttttttt gttgttgttg ttttgttttt 720 tttttttaga tggaatctca ctcttgttgc ccaggctgga gtgcaatggc gcagtctcag 780 ctcactgcaa cctccacctc tggggttcaa gcagttctcc tgcctcagcc tcctgagtag 840 ctgggattac aggtgtgcac caccatgccc cgctactttt tgtattttta gtagagacag 900 ggtttcacta tgttgaccag gctggtctca aactcctgac ctcaggtgat ccgcctgcct 960 cagcctccca cggtgctggg gttacaggca tgagccaccg cgcctggcct gcttggtttg 1020 ttttttaacc agctgtatcc attctgatta aagtgatgtt tttccttccc cctccttcca 1080 atactaattc aatggaagac ttttatttgt tgtgttattt tcaggaatag tagataccaa 1140 cttatataat ttcactattg ttagttatgt gctattatta tgtgagtgcc ctaacattta 1200 tccctggttc agaatatgaa ggctctctgc cctggtgaaa tgtgtgtacc aagaaattga 1260 ctaggaagaa aaacattatt tctaataaac ctgttatcct tctctatatt ttaattttac 1320 gttaggggaa acgtccatgt ttaattggaa ctattcacca ctgtcatttt tagtctggat 1380 tgttggaagt gatgagcact gcactgaagt gtcctttgag tgggtgaatg ttctggcctc 1440 tgagctgttg ttagagggga agagtagagc acacgtgcat ccagagaggg ggccgccctc 1500 ttctgaattt cagacagtga agtgtctatt gacagcactc gttcattccc tgcacactca 1560 tttacctaat acttagtatg ggcctggtat tgttagtccc tgaaaatccc taccctgagg 1620 acgtagttcg catcttctag acccacacgg tctaataagg gagatagtta cattaacttt 1680 aaaacatgtg gtctgtgcat tgttagtgac aaccacatag aagcaccaag gaccagagag 1740 tctcacttat tgtagggaga aatggaaggc tcacagcagc cttcctgtag gaggtggcat 1800 cagagctgga cttagaggac agatttggaa tcagactagt gtttgtgttc tggttaaaga 1860 ttagtacata taaagtgcca attgcagtgc ctgaaacatg gtatgttctc taaaactgac 1920 aaccaccact gctgtcatca tcatcgccat catcatcatc atctgccaga ccttattcat 1980 agtaaaatat attgtgctag gaattaattg atttagttgt gtataaatac cacaaagaga 2040 agaaactttg gcagtagttc tgattattta tttgtggacc aaacaaaaca gttaatccaa 2100 aaaccaaaat tagcccctcc aaaagtcaca aactcttgta gcaaaagatt cacagaacct 2160 ggtagaaaat gtgtggaatg tttccagagc aataatttat tattgttatt tttaatgaat 2220 tagtaagtga atattttaaa catgtctgtt aaaacatgtt aaaaaaaaca tgtttttact 2280 tctaatgtga atatcaatag acataacata taaacaacct ctttagggtc ttcaatgatt 2340 tttttagagt ctgaagagat tctgagacca aaaagtctaa gaacccctgt tctagagaac 2400 aagatcttcc tggaactctg ttccccaggt gacgcttgtg ctgcagggaa gcaggagagc 2460 tcaggctgcc tggcccgtgt acaggctttt tttgaccaaa tattcgttaa catttgcttc 2520 cggtctctcc aagcgagtgg ttctcagtct tagcggcaca ttggaatcac ttggggtgat 2580 taacaaagat gccagtcctc acccctagac tgagtgatgt ggtcggtctg ggatgtagct 2640 ataacatcat gattttttaa atcccgaatg attttgatgt gaagttaagg ttgagaacca 2700 ctgttcaagc caatgagaag gtagccaact tggtaatggc ggaatagggc aacaacagcc 2760 tctagattac tcatttattt aactttcatt gctactaaaa atctcaggga aactacatca 2820 agtccttgtt atcaaagttc aaaatattac tttccataaa aaaggtgaca aataagaaat 2880 tttgacagca gtttaatcat tttgctatgt agatttttaa aaaatagtag ttagacatac 2940 tttgtctaaa caaggataga ttcttagcac acttcttagg ttcccccttc atataccatc 3000 aattagactc ttttttaatt atttatttat ttatgcattt atttattttt ttgagacaga 3060 gtctcactct gtcacccagg ctggagtgca atggagcgac ctcggctcac tgcaagctct 3120 gcctcctggg ttcaagcaat tctcctgcct cagcctcctg agtagctggg attacaggca 3180 cctgccaccg cgcctggcta attttttgta tttttagtag agacagggtt tcaccatgtt 3240 agccaagatg gtctcgatct cctgacctcc tgatctgccc gcctcggcct cccaaagtgc 3300 tgggattata ggcgtgagcc accgcgcccg gccactagac tcttttaact cagcctctga 3360 gttccgtatt gtgcagcagg acttgttaga cctttccaga ggctgctctc ctcttggtcg 3420 tccttgtggg cactgtcggc ccactctgat ttccatccac caacccctca ccaaaggatt 3480 caggtgcatt tagaagcatc catgttacca ttatattgga gcaatcaaaa cataatatgg 3540 atggcgcatc tattgccgtg aatactcttt aaatttatag atgatgggta cattccaaag 3600 cgcaactgaa attattttta tgctcacaat tttgtattac caagaatata actccattta 3660 ttttgtagtc gcatttatct ttatagatta ttactatttt aaactttatg atgagttggt 3720 agttaccact ctcaatgttg gtatgtttat ctccatacta aactttttga tgaagtttga 3780 tggatcatta agaatgatgc aggtgaatag aaatattaac agtttcaaat ttgaaacaac 3840 tgctctcttg aaatcaagag aatcctgctc ttgattctaa aaccacatct ccaagagtga 3900 atgttggaaa gagatgggaa gcaagcctct gtttaaggag gtggtctccg atcctccgag 3960 aggtcaacgt gaaaagaaat gagttttgca ttttgacttg tgcactcccc caacccttga 4020 ctagtgaaca tgcttggttg acccctctcc ttagcctttc aggacagcag gttttacaga 4080 ataattaggc aggtgcatat tctgaacccc aggagtcttt gctacaaacc cattccatcc 4140 catcccctgc tagtctagcc ttaaggatag acatctgctt atacacaggg caaaagtgtg 4200 cttttttctg cagtttttaa gtcatgcctt agaatatggt tctaaaccga gggtgtagtc 4260 cacctctcca aggccaggct tgcactaatg aaacgggaag ttgctgggtt tgtcttgaga 4320 atggccagta catctactcc aaatgctacc ccaggaggca agtatattcc tccccccacc 4380 ctgattaagt ttctaggttt aggcccttac aggggcgctt tgtaatgtcc ccttatagca 4440 cttcatttat ttgattttta aacgccagta tcatcacagc tgtgtatctg gccccccatc 4500 tgccagcact cacaccgcta ggctgagctc ctggaggggg catgtgctct gtttgttgac 4560 aaaaagatta gctaaagccc aaggatggaa actaaggccc cgggccgtga ttgcccgcgt 4620 ttctctgtgg acagtaaatc ttagaaacat catgggggaa ggggtgtgtg tgttccgcgc 4680 ttgtctgtgt gggaaggggt tga ttg gtt ggg tct gtt ctt tcg ctc ctg ata 4733 Leu Val Gly Ser Val Leu Ser Leu Leu Ile 1 5 10 gag tct tct caa aaa cct ctc aca ggc tcc gtc cat gcc aca tcg gta 4781 Glu Ser Ser Gln Lys Pro Leu Thr Gly Ser Val His Ala Thr Ser Val 15 20 25 gca gcc tca aga gtg gag cag gca ctg tcg gaa gtg gct tcg tct ctg 4829 Ala Ala Ser Arg Val Glu Gln Ala Leu Ser Glu Val Ala Ser Ser Leu 30 35 40 cag agc agt gcc cct aag cag ggc ccg ctg cac ccc tgg atg acg ctg 4877 Gln Ser Ser Ala Pro Lys Gln Gly Pro Leu His Pro Trp Met Thr Leu 45 50 55 gca cag atc tgg ctc cat gca gct gaa gtc tat atc ggc atc ggg aag 4925 Ala Gln Ile Trp Leu His Ala Ala Glu Val Tyr Ile Gly Ile Gly Lys 60 65 70 cct gca gaa gcc aca gcc tgt acc caa gaa gct gcc aac ctc ttc cca 4973 Pro Ala Glu Ala Thr Ala Cys Thr Gln Glu Ala Ala Asn Leu Phe Pro 75 80 85 90 atg tcc cac aat gtc ctc tac atg cgc ggc cag att gct gag ctc cgg 5021 Met Ser His Asn Val Leu Tyr Met Arg Gly Gln Ile Ala Glu Leu Arg 95 100 105 gga agc atg gac gag gcg cgg cgg tgg tat gaa gag gcc tta gcc atc 5069 Gly Ser Met Asp Glu Ala Arg Arg Trp Tyr Glu Glu Ala Leu Ala Ile 110 115 120 agc ccc acc cac gtg aag agc atg cag cga ctg gcc ctg atc ctt cac 5117 Ser Pro Thr His Val Lys Ser Met Gln Arg Leu Ala Leu Ile Leu His 125 130 135 cag cta ggc cgc tac agt ctg gcg gag aag atc ctc cgg gac gcg gtg 5165 Gln Leu Gly Arg Tyr Ser Leu Ala Glu Lys Ile Leu Arg Asp Ala Val 140 145 150 cag gtg aac tcg aca gcc cac gag gtc tgg aac ggg ctg ggc gag gtc 5213 Gln Val Asn Ser Thr Ala His Glu Val Trp Asn Gly Leu Gly Glu Val 155 160 165 170 ctc caa gct cag ggc aac gat gcg gcg gct acg gag tgc ttc ctg aca 5261 Leu Gln Ala Gln Gly Asn Asp Ala Ala Ala Thr Glu Cys Phe Leu Thr 175 180 185 gcc ttg gag ctg gag gcc agc agc ccc gcc gtg ccc ttc acc atc atc 5309 Ala Leu Glu Leu Glu Ala Ser Ser Pro Ala Val Pro Phe Thr Ile Ile 190 195 200 ccc cgc gtg ctc tgagcaggcg cctgccagcc tcacctgccg ctcaggcctc 5361 Pro Arg Val Leu 205 agaggccctg ccgggcacca gggcttgtgc catcgcccca aggggatgaa tctgccgcac 5421 tgaggccagg gacgagtgtt cagtgggcca cagtgaacca accaaaccaa ccccgaatca 5481 tcgctctcgc catgtgcgtt tctcttgttt tttttgccag cccaatggta gtttctgaac 5541 ctattgacat tgttcaaaat ggatcatgtg ccatattttg ttagttgaca tctgagtttt 5601 cagtaaaatg attatggaat taatcagcaa atgtagaaga atatattcaa agttaaaatt 5661 cagtggcagc acagattatt tttatcagag ctgtaaagaa aacaactgtc cttttctccc 5721 caccacccct cctgccccac tttggcccag aaaccaaatg tgaacttcct gtctcccacc 5781 tcagcactag tccatgccag gacaccagct gacaatttct tggttttact gtcaataatt 5841 gtaccatgtg atcaattact gtcctcactt agaacaaagc ctgagtccga gaatatttat 5901 attttaccaa tatatgcctg ttacaagaga aggaaatatg agttatttaa gtttaacttt 5961 tttatgtgaa ttcagagttt atttatcgag ggaaatatgt acaaagaagc ttcaaatgga 6021 atatttaccg acattcctta tacatgacag acacttggct acatgggaag atgatgttaa 6081 taataaaatg atttttaaat gg 6103 <210> 9 <211> 5269 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (380)..(790) <400> 9 gaacccatga ccctaaacgg tgctaatagt gcagacagcg acagtgaccc gaaagaaaac 60 ggcctagcgc ctgatggtgc cagctgccaa ggccagcctg ccctgcactc agaaaatccc 120 tttgctaagg caaacggtct tcctggaaag ttgatgcctg ctcctttgct gtctctccca 180 gaagacaaaa tcttagagac cttcaggctt agcaacaaac tgaaaggctc gacggatgaa 240 atgaggtaac gtaagagtac atctgaggca cgtgtggcag catagtagga aatccagtag 300 cctccagatg tgtcagtatt tgaatgctgt agaaatttta taatgaacat tttgaatcct 360 agaatgattt gaattataa tgt ata gga ttt att aac ttg cct ttt aga aga 412 Cys Ile Gly Phe Ile Asn Leu Pro Phe Arg Arg 1 5 10 gta aag aaa aag aaa tcc aaa gac aaa cac cga gac cgc gac tcc agg 460 Val Lys Lys Lys Lys Ser Lys Asp Lys His Arg Asp Arg Asp Ser Arg 15 20 25 cat cag cag gac tca gac ctc tca gca gcg tgc tct gac gct gac ctc 508 His Gln Gln Asp Ser Asp Leu Ser Ala Ala Cys Ser Asp Ala Asp Leu 30 35 40 cac aga cac aaa aaa aag aag aag aaa aag aag aga cat tca aga aaa 556 His Arg His Lys Lys Lys Lys Lys Lys Lys Lys Arg His Ser Arg Lys 45 50 55 tca gag gac ttt gtt aaa gat tca gaa ctg cac tta ccc agg gtc acc 604 Ser Glu Asp Phe Val Lys Asp Ser Glu Leu His Leu Pro Arg Val Thr 60 65 70 75 agc ttg gag act gtc gcc cag ttc cgg aga gcc cag ggt ggc ttt cct 652 Ser Leu Glu Thr Val Ala Gln Phe Arg Arg Ala Gln Gly Gly Phe Pro 80 85 90 ctc tct ggt ggc ccg cct ctg gaa ggc gtc gga cct ttc cgt gag aaa 700 Leu Ser Gly Gly Pro Pro Leu Glu Gly Val Gly Pro Phe Arg Glu Lys 95 100 105 acg aaa cac tta cgg atg gaa agc agg gat gac agg tgt cgt ctc ttt 748 Thr Lys His Leu Arg Met Glu Ser Arg Asp Asp Arg Cys Arg Leu Phe 110 115 120 gag tat ggc cag ggt aag agg aga tac ttg gaa tta gga aga 790 Glu Tyr Gly Gln Gly Lys Arg Arg Tyr Leu Glu Leu Gly Arg 125 130 135 tagaaactat ttcttaatac attttctttg caaaggtgat taacatgtag aaagaaaacc 850 tcaggtggca tcaaagggca cagttactca gagcacccct gccctgcctg gtctggcctc 910 agtgctcatc cctgcagtgt ggttccgttg cacagttaag cccttagcgt ttattgaagg 970 cctaagtgac acaggactga gggcagcact acctgtgtca ccaaagccct ggaacgtaca 1030 gctctaggca tctgactttg ccttgcaaag gaccagaact cttggtttgg tttggtttta 1090 ttttatttta ttttatttat tttatttttt gagacggagt cttgctctat tgcccaggct 1150 ggagtgcagt ggcggcgatc tcagctcact gcaacctctg cctcccaggt tcatgctgtt 1210 ctcctgcctc agcctcctga gtagccggga ctacaggcgc ccgccaccac gcccggctaa 1270 attttgtgtt tttagtagag acggtgtttc accgtgttag ccaggatggt ctcgagaact 1330 cttggtttta aagcattttt gatagaaata cttttgcagc gtatacgtta ctctcccgaa 1390 tccttaaacc tgtagcattc tgagtgcacc ctgatgctcg gtactgattt gctcgcttgg 1450 ttccttagaa gcgtgggcac cagcctctgc ttgagtgaca ctgcagaggc ctccatgtgg 1510 cagagcgctg gctgcccctg ccaggtgtcc tggattctct tctgccctgt ggggctgtgt 1570 ctccgtcctg tggccacacg ctgtgctctt actgcacttg aggcagcccc ccacttcctc 1630 tcccgttggt gtccggtgac cgctcaccct cgagaggagc tgtgagcctg ttagaagcgg 1690 atgtcactcg agtcagtgga cctagagcgg aggctggcaa actgcagccc tggggccaac 1750 ttcggccagt caccagactt tgtatgaact tggagttaag aatggtttta acctttttaa 1810 gtggttggaa ataatcccaa agaacaatgc gtttcacatg aaaatgatgt gaaattcaga 1870 cctcagtgtc tgtggcttga ttggggcgca gccaggtgcg ttcccacgct gtctggcggc 1930 ttcgctgtca ctgcctggca gaggtgagtg gctgcggcag ggcagggacc gtgtggctcg 1990 caaagcggaa aatgtttatt attgcccctt gacagaaagg gtttgtcacc cctgcctgga 2050 cgcccattgt ttgtgttcac gtgtgaagcg catcccctcc tcccaggggc ttttgacgaa 2110 tcttcagggc tgccctgagg ccttttgctt ctcggctgag ttgtgggtta ggtggagctg 2170 tgtgttctgg ggaaggcctg tccctcccag cagcccagag ccagcatgca ttgttgattg 2230 aggggtaaac ggtccttaga gtgtgtgaga gagagctggg ggttgcaggg tgagccccat 2290 gggggacatt tgcccatgga gtgctgggga aacagccgga gatgaggaca ggcaccagca 2350 ctgccggtga ggacgggttg cctgcgggcc ttgtagacgt tctggacatt tcagaattgg 2410 ttttgcgttc ccatttcagc gaatcgggga aggagattcg tgagggctgc ttggtacccg 2470 aggatccgag gatgcagtgg atgggctcat tctgagtgtg gtgcaggctc ccaggatcat 2530 gggcttccag ctggggctac tgggagacag tgatggcccc cgaggcagct ggtccagcgg 2590 gagggaggtt gaacgtgatc ttgtttgcct cgtgtctcgg gtgctgtggt caggcgttgt 2650 ctgtgtggtg gccctgtgtt tccgtccccg tcccactgca ccgatgacag ggtttgcagc 2710 tggcgcttct gctgcgagca gactgaggag cctttcttgt ccttctgaga aggccgctgc 2770 ccggccccgc ctcacccagc gtcctgtggt cctgcgggtc cccctctacc ctggacttcg 2830 gccccttgtc tttctctttc aaactcctcc tctggctctg ttccgcccag ttcagttctt 2890 gggcctgata tctgttctaa catcaggctg cgtgtgggtt ggatggagcc ctcagtcatc 2950 acgtaaaccc tttgacatca gtaaaaccct gggagcagcc gctgagcgct gggacatccc 3010 tgctcacctc actggggagt ggcctcaggc gctcacaggg aaccgcagtg actctgacca 3070 tagccactta acgcacacac acagcagagg ccctggcgat tttgcaacca tcattaaaat 3130 ctctttcctg acctttgctt tctaggtgat tgaaaactca gcctcaaaac aaaaaattca 3190 ctagttatgg taagctgttt tcctgtctgt ttcctcattg tttgtggtgg tgctgagggg 3250 acgcaggcag aggagtttta attctgcggc tctgcctggg ggctgggctc ataggagttg 3310 gcagagccat ggagaggccc cggcaggttc ccagccagcc cagacccagg ccacgcgctt 3370 ggggacagac ctagaccctc cacctcatca cgtttgcatt actggctggg gaagacccgc 3430 atccttcacg caggcagagt cgccctgttc ccttgtgcct cacttgggaa aagccaaccc 3490 ggctcacagc ggcagagccc acgggccttt gataaacatc tgggaaggga gaggcccggt 3550 ccccagcaca ggcacctcac tcaggagagc ggagccttgc tccctcgtcc gtcccgtccc 3610 ctgtgctgct gtctgcgccc cgaggtggca ctgagctgga gccagcaccc ccccagcagc 3670 caccgtacaa aaccatagga aggtggccca gggccgggcg gcagatcagg acctcggagc 3730 tgtggggctt tgttggatca cttcacacag cggtcctggg agagtcactg gttttatacc 3790 tgacccttgt ggagctagag gggacagtga accatttttc ccttgaaagg aaactttgtc 3850 caaatgtgtc tgtcacatgt agtcagcaag aggaatttaa aatgaattgc caagtgaaga 3910 gtctgtggat taattggccg ttaattaaca ggctttatca atgtgtcctc aagggagagg 3970 cccaacccta attaaggagc taaacttcct gagtgagggg ctgtgaggat ggaggtggag 4030 gaggcatctg gggcgggtgg tggccgggcc cagcagatgg cgcctccctg gctgagctgc 4090 ccgcaccgcc agttccctca tttccactca ggaaggcaga gaaggcagag tgatctcctc 4150 aaggaagagc ttccccagcc ttcgggagca gctggcaggg cgtccgggaa taagccctac 4210 acgccgccgc ctgcctccaa ctcactaacc ctgcgcctct tgtctttcag attcaacgcg 4270 ttcaacagaa gccatcccca gcccagctta aattataaag atagacaata actctgttcc 4330 aatctgcgtg gtgcttcttt agtaaatact gtacagattt taccatggag aacttttttt 4390 ttagttttta ccttttctta attaccctta ttccgaatgg acgaacactt tctaccactg 4450 ctgaccattg taaaataccg tgtatataaa tcccattgaa ataatgccct ggaatagaac 4510 atctcaaatg ctgcttaatt acagactcag gtcgattact tgtatttcat gtaatgttcc 4570 tccaagttag acatctggtg caagaccaac cgggagacca tggaattgtc aaaagtacaa 4630 actgacagtg tgtatattta atttaaagac ttatttaaaa actcacaagc tctcacctag 4690 actttggaga gcagtctgtt ttctgtaatg tctgatacta gaaactaatt tgcttatttt 4750 agttgtattc aagatttgaa gatgtatttt atagacaagt tctgtttttg aactttgtgg 4810 aactgttcca atcaatcaat ttcccagtta tgatgagtat ttacattatg aatgtataac 4870 ccagacatga tttgtaaagc cgacagtatg tttctattac acaacacttt ttgatacagc 4930 gtctcttgtc ttcactgata ctggagtctc cgttgtctgc ttggtccctt cgagtttcta 4990 gttacagaca caatcatact gtgattttat ttttaatatg gatatgctat caaactgtga 5050 tacacttata attcactggt cctgcatcag gagatggagt ggggaaaact gtatttaata 5110 cagtttgtat ctgaataatc tgtatggttt atacagtttg tgttgttcag agatgtttaa 5170 agtttgatct ttgtttttct aaagattaaa aaagcacttg ccccactgta aatatacagc 5230 atgtaaaatt tctatagtat ataaatggca gcaaatcac 5269 <210> 10 <211> 5363 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(1829) <400> 10 gc ggc cgc gac ccc gac ggc ttc ctg cgc gtg gag cgc gtc gcg gcg 47 Gly Arg Asp Pro Asp Gly Phe Leu Arg Val Glu Arg Val Ala Ala 1 5 10 15 ctc gga ctg cgc ttc ggc cag ggc gag gag gtg gaa aaa ctt gtg aaa 95 Leu Gly Leu Arg Phe Gly Gln Gly Glu Glu Val Glu Lys Leu Val Lys 20 25 30 tat ttg gat ccc aac gac ctg ggg aga atc aac ttc aag gac ttt tgc 143 Tyr Leu Asp Pro Asn Asp Leu Gly Arg Ile Asn Phe Lys Asp Phe Cys 35 40 45 cgg ggg gtg ttc gcc atg aaa ggg tgc gag gag ctg ctg aag gat gtg 191 Arg Gly Val Phe Ala Met Lys Gly Cys Glu Glu Leu Leu Lys Asp Val 50 55 60 ctg tcg gtg gag agc gcg ggg acg ctg ccg tgc gcg cca gag atc cca 239 Leu Ser Val Glu Ser Ala Gly Thr Leu Pro Cys Ala Pro Glu Ile Pro 65 70 75 gac tgc gtg gag cag ggc agc gag gtc aca ggc ccc acc ttt gct gat 287 Asp Cys Val Glu Gln Gly Ser Glu Val Thr Gly Pro Thr Phe Ala Asp 80 85 90 95 ggc gag ctc atc ccc agg gaa ccc ggc ttt ttt ccc gag gac gag gag 335 Gly Glu Leu Ile Pro Arg Glu Pro Gly Phe Phe Pro Glu Asp Glu Glu 100 105 110 gag gct atg acg ctg gcg cca cct gag ggc ccc cag gag ttg tac aca 383 Glu Ala Met Thr Leu Ala Pro Pro Glu Gly Pro Gln Glu Leu Tyr Thr 115 120 125 gac agc ccc atg gag agc act cag agc ctg gag ggg tct gtc ggg agt 431 Asp Ser Pro Met Glu Ser Thr Gln Ser Leu Glu Gly Ser Val Gly Ser 130 135 140 cct gcc gag aag gac ggg gga ctt ggg ggc ctg ttt ctg cca gaa gac 479 Pro Ala Glu Lys Asp Gly Gly Leu Gly Gly Leu Phe Leu Pro Glu Asp 145 150 155 aag tcc ctg gtc cac act cca tcc atg acg acc tca gac ctt tct aca 527 Lys Ser Leu Val His Thr Pro Ser Met Thr Thr Ser Asp Leu Ser Thr 160 165 170 175 cac tcc acc acc tcg ctc atc agc aat gag gag cag ttt gaa gac tat 575 His Ser Thr Thr Ser Leu Ile Ser Asn Glu Glu Gln Phe Glu Asp Tyr 180 185 190 ggg gag ggt gac gat gtg gac tgt gcc ccc agc agc cct tgc ccc gat 623 Gly Glu Gly Asp Asp Val Asp Cys Ala Pro Ser Ser Pro Cys Pro Asp 195 200 205 gat gag acc agg acc aac gtc tac tcg gac ctg ggg tct tcg gtg tct 671 Asp Glu Thr Arg Thr Asn Val Tyr Ser Asp Leu Gly Ser Ser Val Ser 210 215 220 tcc agt gcg ggg cag acg cct agg aaa atg cgg cac gtg tac aac agc 719 Ser Ser Ala Gly Gln Thr Pro Arg Lys Met Arg His Val Tyr Asn Ser 225 230 235 gaa ttg cta gat gtt tac tgc tct caa tgc tgc aag aaa atc aac ctg 767 Glu Leu Leu Asp Val Tyr Cys Ser Gln Cys Cys Lys Lys Ile Asn Leu 240 245 250 255 ctc aat gac ttg gaa gcc cga ctg aaa aac ctg aag gcc aac agc ccc 815 Leu Asn Asp Leu Glu Ala Arg Leu Lys Asn Leu Lys Ala Asn Ser Pro 260 265 270 aac cga aag atc tcc agc acg gcc ttt gga cgg cag ctc atg cac agc 863 Asn Arg Lys Ile Ser Ser Thr Ala Phe Gly Arg Gln Leu Met His Ser 275 280 285 agc aac ttc agc agc agc aat ggc agc acc gaa gac ctg ttc cgg gac 911 Ser Asn Phe Ser Ser Ser Asn Gly Ser Thr Glu Asp Leu Phe Arg Asp 290 295 300 agc att gac tct tgc gac aat gac atc aca gag aag gta agc ttc ctg 959 Ser Ile Asp Ser Cys Asp Asn Asp Ile Thr Glu Lys Val Ser Phe Leu 305 310 315 gaa aag aag gtg aca gag ctg gag aat gac agc ctg acc aat ggg gac 1007 Glu Lys Lys Val Thr Glu Leu Glu Asn Asp Ser Leu Thr Asn Gly Asp 320 325 330 335 ctg aag agc aag ctg aag caa gag aac aca cag ctg gtg cac agg gtg 1055 Leu Lys Ser Lys Leu Lys Gln Glu Asn Thr Gln Leu Val His Arg Val 340 345 350 cat gag ctg gag gag atg gtg aag gat cag gag acc acg gcc gag cag 1103 His Glu Leu Glu Glu Met Val Lys Asp Gln Glu Thr Thr Ala Glu Gln 355 360 365 gct ctg gag gag gag gcg cgg cgc cac cgc gag gcc tac ggc aag ctg 1151 Ala Leu Glu Glu Glu Ala Arg Arg His Arg Glu Ala Tyr Gly Lys Leu 370 375 380 gag agg gag aag gct acc gag gtg gag ctg ctc aat gcc agg gtg cag 1199 Glu Arg Glu Lys Ala Thr Glu Val Glu Leu Leu Asn Ala Arg Val Gln 385 390 395 cag ttg gag gaa gaa aat aca gag ctt aga aca aca gtg act cgg ctc 1247 Gln Leu Glu Glu Glu Asn Thr Glu Leu Arg Thr Thr Val Thr Arg Leu 400 405 410 415 aag tct caa aca gag aaa ctg gat gag gag cgg cag cgc atg tct gac 1295 Lys Ser Gln Thr Glu Lys Leu Asp Glu Glu Arg Gln Arg Met Ser Asp 420 425 430 cgt ctg gag gac acc agc ctg cgg ctc aaa gat gag atg gac ctg tac 1343 Arg Leu Glu Asp Thr Ser Leu Arg Leu Lys Asp Glu Met Asp Leu Tyr 435 440 445 aag cgc atg atg gac aag ctg cga cag aac cgc ctt gag ttc cag aag 1391 Lys Arg Met Met Asp Lys Leu Arg Gln Asn Arg Leu Glu Phe Gln Lys 450 455 460 gag cgg gag gcg acg cag gag ctc atc gag gac ttg cgg aag gag ctg 1439 Glu Arg Glu Ala Thr Gln Glu Leu Ile Glu Asp Leu Arg Lys Glu Leu 465 470 475 gag cac ctg cag atg tac aag ctg gac tgc gag cgg cca ggc agg ggc 1487 Glu His Leu Gln Met Tyr Lys Leu Asp Cys Glu Arg Pro Gly Arg Gly 480 485 490 495 cgc agt gcc tcc tct ggc cta ggc gag ttc aat gcc agg gcc cgc gag 1535 Arg Ser Ala Ser Ser Gly Leu Gly Glu Phe Asn Ala Arg Ala Arg Glu 500 505 510 gtg gag ctc gag cac gag gtc aag cgg ctc aag cag gag aat tat aag 1583 Val Glu Leu Glu His Glu Val Lys Arg Leu Lys Gln Glu Asn Tyr Lys 515 520 525 ctg cgg gat cag aac gac gac ttg aat ggg cag att ttg agc ctc agc 1631 Leu Arg Asp Gln Asn Asp Asp Leu Asn Gly Gln Ile Leu Ser Leu Ser 530 535 540 ctc tac gaa gca aaa aac ctc ttt gct gcc cag act aaa gcc cag tct 1679 Leu Tyr Glu Ala Lys Asn Leu Phe Ala Ala Gln Thr Lys Ala Gln Ser 545 550 555 ctg gct gca gag ata gac acc gcc tcg cgc gat gag cta atg gaa gcc 1727 Leu Ala Ala Glu Ile Asp Thr Ala Ser Arg Asp Glu Leu Met Glu Ala 560 565 570 575 ctg aag gag cag gag gag atc aac ttc cgg ctg agg cag tac atg gac 1775 Leu Lys Glu Gln Glu Glu Ile Asn Phe Arg Leu Arg Gln Tyr Met Asp 580 585 590 aag att atc ctc gcc atc ctg gac cac aat ccc tcc atc ctc gag atc 1823 Lys Ile Ile Leu Ala Ile Leu Asp His Asn Pro Ser Ile Leu Glu Ile 595 600 605 aaa cac taaggcacgg ggctggctgc agagcagcct taggaccctg ggaccaaggg 1879 Lys His cagaccctgc ccaaggatgc aggcctaagc cgggcctcac actcacactg taaatgtctc 1939 tctggccacc atgcgttacg tgtacccgtg tatatgtggg gaggctgtgc acacgagcga 1999 ggggtgagtg gccgtggctg tgggcagcat ccacacggtt agccgtgcat gcactttgtg 2059 gcccctttgc aaggggcaga gggtactgga agtgggagga ggcaaggtct gctatcagga 2119 gttactgtaa aaacaagaac tggaagctcg tgtttccggt actgggtaaa atgattctac 2179 ctctggggat aaggattcac attcgctcta gtacgatggg ctctttcacc ccactcctag 2239 tccccttggg agtgggagca aaattgtgat ctttcctagg agtttgaatg ccccatattt 2299 gtgtcctcgc cagctctttg gccacctttc aagccccagt gttcaagctc agagaggatg 2359 aaggggcatc tggagggtcc atgagatggg gccctcacca aatgccttgg ccaccggcca 2419 gcagccctct gtgatgtgtg tgcagagtga acagaggact caggtttcat agcagctagt 2479 gcggggcatc ctcatcctgt acctatagag ttcgtgcact cccccatcca tgctacctac 2539 ctccccgttt ctgtttcagt tttaagacaa tgaagcagca ttcactgcgt cattgtaaca 2599 tgaagggata aaaatgaagg agaaggaggg tttgggatgg gtgtctaagg caggagttga 2659 catcgggcaa ccaaagaaat gagttttggg gaggaacaca actcccatcc cagtcagttt 2719 ccttcccatg gctgcatctt aagatggatg cacggagaaa ccgtctgcct ggctccctgt 2779 cttcattctc cacgcagcct ggtgatggca ggcctgggtt tggatttcag aatcctagct 2839 ccgggctcca ctcgtgtggc agcaagactg cttcgttcca gcgtttagaa acacacctgt 2899 atttgattct cagccagggg agcactcgct gcactggtgg gaggcggttg ggaaagttgc 2959 aggaaaacct tagtcttcca tccttctgac ccatggtgga aattcacacc atggattttt 3019 aatggatctt tgttctaggc agctgggaat agacatggta cttaccttag agttttccaa 3079 tttatctcaa ttttatatgg cttgtgattc attttcttaa tccaaatata tataaacgtg 3139 tgtggtctta ttcttccccc tgcagtttct tgctttcttc agcacatctt atagtatgag 3199 aaggaaggtt tgggcatgtt gggaagggcg gtggagggcg agttgcagaa agagagggca 3259 gtgagggtga ggagagggga tctggggact tgggtgtgac acctgcttga cagaggcagg 3319 gctgtggcca ggaccaacct tcaattccat tccaatcagc ctttgcattt gttggatctc 3379 gtggcttctt tttaatcttt tgttggggat tagtttcatg ctgcacataa tggggttgca 3439 ctggtctgac ccaggacttt ggagccaccc acactgggaa gactaggcta ggcagtcggt 3499 cttctaggag tttctcagcc ccttaggacg cgggtctcct tgggctcccc caagggttct 3559 gcgaagaggc agtggaagaa ggcatgagga gagggtctct tgagaatttg ccaataggaa 3619 ggagtggcca cggctgaaag gaacaagaca gatcctgaca tagctttggc ctgggtgtta 3679 ggtcagaagg agtactggtg catgggggcc ttaccccagg gttgagtatt ttatatgtaa 3739 aatgttatct gccctttggc tgcattggaa tttcagagaa ggctgcagag gcctgggtta 3799 cacagcctga gtcacaacgt gggaaggaat ctctgccacg ggaaaggtgg gcggaagcag 3859 ctggcagcct ggggcgtgct tcaggctcct ccctctaagg ggcgccatgg gaacaggctc 3919 cggagggagc cggcgtctga aaggcccccg ggacctgctg cagtgccaga ggggcctctg 3979 gagcaggcct ggcttttaaa tggggggctg aattccagct cacacacacc tcaagtccaa 4039 ccttactttc ttcagccaga atacatttct tgtaaaacct ggcttgttgc ttggctttta 4099 aagatggtgt atgtttgtaa aaatattctt ctgggctcaa aagctagctt gagggggcag 4159 atgccccagg tgtcccagct ccacagcccc tggcagatcc cagacccctt ggtggcaggt 4219 cccagagcct aggtggtagg agcttgatct ttgtttctgc ccttacccct cagtagtggg 4279 gctgcgaggt agtagacagg atgcccagtt aagtttgaat ttcagataga aaataatttt 4339 agaataaata tgttctatct aatacatggg acagatgtta tttttagaga taggatcttg 4399 ctctgttgcc caggctggag tgtagtggta tgatcatagc tcaccacaac cttgaactcc 4459 caggctcaag cgatcctccc gccttaactg cctgagtagc tgggactaca ggcatgcacc 4519 accacgccca gctaattttt cttatttttt gtagagacag ggtctcactg tgttgcctca 4579 ctcgagctgc tgacctcaag tgatcctccc acctcagcct gccaaagcac tgggattaca 4639 ggcatgagcc accatgcctg gccaggacat atttgaaatg gggagatttt aaaaattctg 4699 atgattagac tgaatcctca gacgttctgg tttgattgtt gtgggtgtag cccaggcatg 4759 ggatttttta aagagctgct caggtaattc caatttaatt gcgtgtccta cttgggtttt 4819 ttgtttgttt ttattgtttt tgctaaacct ggcaacccta ccgagtaggg attagcagta 4879 acttatctga aatttagagg tgttttgggg gtggggcgag ggtttctgta gtagactcag 4939 attttacatg gccctgagct gcccttgcgt tcagttggaa gccacgcaaa atgaactgaa 4999 ccaggagtga gcttcgtgta cattatctat tagaaaatga agtaccttct ggttcagcta 5059 gtccctgtgc gttgagaggc tttaagaaac ttctagtaaa aatgtttttt tcttttagct 5119 ttgaattggc cagagtttat cctagattat tttattttaa attggtagaa ttctttgcga 5179 actgtcacag agaaattcct tttcatgact ttatttctga cctattaaaa catgaacagg 5239 ccaggcatgg tggctcacgc ctgtaatcct agcacttggg aggcagtggc aggcggatca 5299 cttgagctca ggagtcctaa accagcctgg gcaacatagt gataccttgt ctctaccaaa 5359 agtt 5363 <210> 11 <211> 5399 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(1601) <400> 11 gt ggc ttc ctg ggc att gcc ttc cac ccc agc ttc cag cac aac cgc 47 Gly Phe Leu Gly Ile Ala Phe His Pro Ser Phe Gln His Asn Arg 1 5 10 15 agg ctc tac gtc tac tac tca gtg ggt atc cgc agc agt gag tgg atc 95 Arg Leu Tyr Val Tyr Tyr Ser Val Gly Ile Arg Ser Ser Glu Trp Ile 20 25 30 cgc atc agc gag ttc aga gtc tcc gag gat gac gag aac gcc gtg gac 143 Arg Ile Ser Glu Phe Arg Val Ser Glu Asp Asp Glu Asn Ala Val Asp 35 40 45 cac agc tct gag agg ata atc ctg gag gtc aaa gaa cca gcc tca aac 191 His Ser Ser Glu Arg Ile Ile Leu Glu Val Lys Glu Pro Ala Ser Asn 50 55 60 cac aac ggg ggc cag ctg ctt ttc ggg gat gac ggg tac ctc tac atc 239 His Asn Gly Gly Gln Leu Leu Phe Gly Asp Asp Gly Tyr Leu Tyr Ile 65 70 75 ttc act gga gat ggc ggg atg gcc gga gac ccc ttt ggg aca ttt gga 287 Phe Thr Gly Asp Gly Gly Met Ala Gly Asp Pro Phe Gly Thr Phe Gly 80 85 90 95 aat gcc caa aac aag tcg gcg ctg ctg ggc aag gtg ctg cgc atc gac 335 Asn Ala Gln Asn Lys Ser Ala Leu Leu Gly Lys Val Leu Arg Ile Asp 100 105 110 gtg gac cgt aag gag cgc ggc ctg ccc tac ggc atc ccg ccc gac aac 383 Val Asp Arg Lys Glu Arg Gly Leu Pro Tyr Gly Ile Pro Pro Asp Asn 115 120 125 ccg ttc gtg ggc gac ccc gcg gcg cag ccc gag gtc tac gcc ctg ggc 431 Pro Phe Val Gly Asp Pro Ala Ala Gln Pro Glu Val Tyr Ala Leu Gly 130 135 140 gtg cgc aac atg tgg cgc tgc tcc ttc gac cgt ggc gac ccc tcc tcg 479 Val Arg Asn Met Trp Arg Cys Ser Phe Asp Arg Gly Asp Pro Ser Ser 145 150 155 ggc act ggc cgc ggg cgc ctc ttc tgc ggc gac gtg ggc cag aac aag 527 Gly Thr Gly Arg Gly Arg Leu Phe Cys Gly Asp Val Gly Gln Asn Lys 160 165 170 175 ttc gag gag gtg gac gtg gtg gag cgc ggc ggc aac tat ggc tgg cgc 575 Phe Glu Glu Val Asp Val Val Glu Arg Gly Gly Asn Tyr Gly Trp Arg 180 185 190 gcg cgc gaa ggg ttc gag tgc tac gac cgc agc ctg tgc gcc aac acc 623 Ala Arg Glu Gly Phe Glu Cys Tyr Asp Arg Ser Leu Cys Ala Asn Thr 195 200 205 tct ctc aat gac ttg ctg ccg att ttc gcc tac ccg cac acg gtt ggc 671 Ser Leu Asn Asp Leu Leu Pro Ile Phe Ala Tyr Pro His Thr Val Gly 210 215 220 aag tcg gtc aca ggg ggc tac gtg tac cgg ggc tgc gag tac ccc aac 719 Lys Ser Val Thr Gly Gly Tyr Val Tyr Arg Gly Cys Glu Tyr Pro Asn 225 230 235 ctg aac ggc ctc tac att ttt ggg gat ttc atg agc ggg cgt ctg atg 767 Leu Asn Gly Leu Tyr Ile Phe Gly Asp Phe Met Ser Gly Arg Leu Met 240 245 250 255 tcc ctc caa gag aac cca ggg aca ggc cag tgg cag tac agt gag atc 815 Ser Leu Gln Glu Asn Pro Gly Thr Gly Gln Trp Gln Tyr Ser Glu Ile 260 265 270 tgc atg ggc cac ggc cag acc tgt gag ttc cca ggc ctc atc aac aac 863 Cys Met Gly His Gly Gln Thr Cys Glu Phe Pro Gly Leu Ile Asn Asn 275 280 285 tac tac ccg tac atc atc tcc ttc ggg gag gac gag gcc ggg gag ctg 911 Tyr Tyr Pro Tyr Ile Ile Ser Phe Gly Glu Asp Glu Ala Gly Glu Leu 290 295 300 tac ttc atg tcg aca ggg gag ccg agt gcc aca gct cca cgc gga gtt 959 Tyr Phe Met Ser Thr Gly Glu Pro Ser Ala Thr Ala Pro Arg Gly Val 305 310 315 gtc tac aaa ata att gac gca tcc agg cgg gca cca cct ggc aaa tgt 1007 Val Tyr Lys Ile Ile Asp Ala Ser Arg Arg Ala Pro Pro Gly Lys Cys 320 325 330 335 cag atc cag cct gct cag gtg aag atc aga agc cgt ctc atc ccc ttt 1055 Gln Ile Gln Pro Ala Gln Val Lys Ile Arg Ser Arg Leu Ile Pro Phe 340 345 350 gtg ccc aaa gaa aag ttc atc ccg aag aca cgg agc acc ccg cgg cct 1103 Val Pro Lys Glu Lys Phe Ile Pro Lys Thr Arg Ser Thr Pro Arg Pro 355 360 365 aca gcg cgg gcg ccc acg cgg gcg ccc cgc cga ggg cgc ccc acg gcc 1151 Thr Ala Arg Ala Pro Thr Arg Ala Pro Arg Arg Gly Arg Pro Thr Ala 370 375 380 gct ccc ccc gcg cca acc ccg cgg cca gcg cgg ccc acc cag cag cca 1199 Ala Pro Pro Ala Pro Thr Pro Arg Pro Ala Arg Pro Thr Gln Gln Pro 385 390 395 ggg agc cgg agg ggc ggc ggg cgg cgg cgg ggg cgg ctg aac tcg gcg 1247 Gly Ser Arg Arg Gly Gly Gly Arg Arg Arg Gly Arg Leu Asn Ser Ala 400 405 410 415 agc cgg gcg ttc cgg gat ggc gag gtg cgc ctg gtg cgg ccc gcg ggc 1295 Ser Arg Ala Phe Arg Asp Gly Glu Val Arg Leu Val Arg Pro Ala Gly 420 425 430 ctg agc tct ggc agc ggg cgc gtg gag gtg ttc gtg ggc gga cgc tgg 1343 Leu Ser Ser Gly Ser Gly Arg Val Glu Val Phe Val Gly Gly Arg Trp 435 440 445 ggc acc gtg tgc gac gac tcc tgg aac atc agc ggc gcc gcc gtc gtg 1391 Gly Thr Val Cys Asp Asp Ser Trp Asn Ile Ser Gly Ala Ala Val Val 450 455 460 tgt cgc cag ctg ggg ttt gcc tac gcc gtg cgc gcc gtc aag aga gcc 1439 Cys Arg Gln Leu Gly Phe Ala Tyr Ala Val Arg Ala Val Lys Arg Ala 465 470 475 gag ttc ggc cag ggc ggc tcg ctg ccc att ctg ctg gac gat gtg cgc 1487 Glu Phe Gly Gln Gly Gly Ser Leu Pro Ile Leu Leu Asp Asp Val Arg 480 485 490 495 tgc gcg ggc tgg gag cgg aac ctg ctg gag tgc cag cac aac ggc gtg 1535 Cys Ala Gly Trp Glu Arg Asn Leu Leu Glu Cys Gln His Asn Gly Val 500 505 510 ggc acc cac aac tgc gag cac gac gag gat gcg ggc gtc gtg tgc agc 1583 Gly Thr His Asn Cys Glu His Asp Glu Asp Ala Gly Val Val Cys Ser 515 520 525 cac cag aac ccc gac ctg taggcaacac gccgctgccc caggccatcc 1631 His Gln Asn Pro Asp Leu 530 cgccggcggg ggagcctggc aggggccgct ccgccctgtg tgcgcccagc gggtgcacac 1691 gtgttctaga gtgaaggggg tgcgggtgtg tgctgtcctg gggacatgtg tgaggcgctg 1751 cagtgcatgt gtgtcctctg cagacccaag gcaggagtgt gtgttggggg cggtgtgggc 1811 tctggaagtg catggtccat catgggcggg aggagttcct ttcttacctc caagcgtttc 1871 agacaccagc aggaacagca gccgggctgt gggaccctga ggagggaggg cagccaggct 1931 tcgaggacgg acatggcccc tggctgtgct aacagaggca cagcttgcag actgagggcg 1991 gtggggagaa ccaggcttgt cctgcccaca gctggaatgg aaggtgcaag aacagccgga 2051 gggtggcctg aggaatgtgg cccggacagc atggcctggt gcccgcatcc cccccacccc 2111 ctggcagtca gaggcgctgg agagaaccgg aaggcatcca gtggggaagg gaaagccttc 2171 tggaaggtgg gagcagggtg agctgcaggc ctggggcccc actggagggg caggctgcgt 2231 ggaggagcca gcacctgctc agggaggatg gctgtgagga ctggatgacc tccaaggccg 2291 tatgctggag aagccactca gcagcatact cagtccttgt gggtgctcct gggatgggac 2351 cagcctcctc caaccctgag gcctgattct ctcttgctct tggggcagaa gccacccaca 2411 ctagctgggc agagctttca ccctggccct ccagtgagtc ggtgggcctc cactactttc 2471 aaagctgtgt ttgggccctg gggccacctc tgtcctttcc atccccatcc ctgctcagtg 2531 taaacccagg agacctgatt cctccagccc tacctcgggg ctgaccaggc tgggggtcca 2591 gtgaaactac tgacactttt tcacccaggg ctatgccaat aatgtggctg tttacacacc 2651 actttcctgc ctcctctctg acctgcacct gtgtgggagc cggggtggga accaggagaa 2711 aggggtgagg cctcccgctt cccacctgca tcacaggtgg aagctccttc actccaggga 2771 tgctcggccc tggctctgtg ccaggccgca gaggggcact tagtatgact gcgctcagcc 2831 tcggatggga gcacgggtgg gggtgggtaa gcagatgagt caccaggcag tgaggacagg 2891 atgtggccca tgtcgggggt tggaagaggt ctgggtgggg cacccaaacc caacctatgg 2951 gggggctttg ggagggggtg atgctgtgcc aagttctggg agctggcacc aggggtggct 3011 gggcaggcct tggggcaggc atgagtctgg cagggtctcc tagctgctag tatagggtct 3071 cctagccact agtataggat cctgggctgc agcagaaagc tttaggtcac tgtcttggac 3131 tcctcatact ctgtgcttta cagaatggga aactgaggca cacagaggtt agatatctta 3191 gggcaccaag ccagggaagg gagaagtcaa gtttgaatac agcagcttag tttagagtcc 3251 ccgcacccta accactgccc tccccagctc cactatgcct gcagagagcg gtgtgctggg 3311 gctcctgcct ggtgtgggag tgccagcctg gctgggaagc agctgatgga gatccctggg 3371 ggctcctctt gcctggcagg tgcccccgct gctggcctca tgctcctctc gggcctccag 3431 tggcccaggg gaggttgagt gggcatcttc ctgggatgca ggggagttct gagctctgac 3491 gccgggcgtg ttaggagata gcaggccgtt aatgaccatc ccagccgaat tcctcactgt 3551 gcagatgagg aagtgagctc agggaggctg agtgtcccag gcctgttgcc agatgaggcc 3611 acgctgagac tggagccagg gaaggtgcag caagccttga ggccctcaag aatgcagccg 3671 agccagggcc ctgcttgcct ggccccagaa gctgttttgc tcagagctgg attaggaggg 3731 ttggcaaagg gagctctggg tgcggcctca ggccctccag tacttctctg ggcagttcgg 3791 gctttggcct tcagtcttcc aggccaggcg ctcttcctcc ccagcctcca actcatcacc 3851 tctcaggccc caaaccaggc ctgggctagg ctgcagcctg cctcctgggg actcactcca 3911 cagtccccag gtcagtggtc cccaaccttt ttggcatcat ggactggttt catgtaagac 3971 aatttttcca tggatggggg ttggggggat ggttttggga tgaaatgtcc cacctcagat 4031 catcaggcat tagattctca taaggagttc acagcctaga tccctcgcat gcacagttca 4091 tagtaggttt catgttccta tgcggatcta atgccactgc tgatctggca ggaggcagag 4151 ctcaggtggg aatgcttgct ccccacacta ccctgcccca ctgccactca cctcctgctg 4211 tgtggcccgg ttcctaacag gccacccatc agtactggtc cgtggcccag ggtttggaga 4271 cctctgccct aggtagtaat aagagtggac agctgttata tgtaaatact tgttccccga 4331 tgctggaaag aaatagcact aaaacataaa tttaattctt tcagcaaggc aattttactt 4391 tctgcagaaa gggtgctcat cgcagatgga acaatagtga gaggacacct gaacaaagga 4451 gggaagcaat tgttagccct tatgcagttt gtccctgcta ctgtgtccta tgtccattgg 4511 cagaagccag accgcacaat ctaaactaaa acccgattgg ctgtttaaaa tttttctaaa 4571 taggtaaaag taatggaagg ataaaggaaa agaggaagtt gcttacgaaa ggacttagaa 4631 aagtaataat attcccaaat aaggaagggg tataggctgt gagctgggac atgcctgtga 4691 gcacgtccag cacagatatc ttggttaaag tataaggaca tagaacgtac tatgtgcctg 4751 tgagcacgtc taacagttac atagaatagg gcttgacaaa gagttattag cataaagcaa 4811 ggaggtttga aggaagttcg tctttaaaag aaaccattat ttctaacact tacgatttat 4871 tctttaacaa gaagggaaac tttcaagagg aacttttact ttctacaaca gctgacctct 4931 gctgagcgct tactacatgc caagcactgc tctgaaagtt taacatacca ttcactcatg 4991 taatcctcat attaatgcac atttactcac gtggaagccg agttccaggg catttgtcac 5051 ttaccaaatg tcacatagcc aaaatttgaa tttgagccca ggtagtccag ctctgggacc 5111 ctgctgtggg ccttcctgct gggccacctc aagggcattg aaagccagcc ccaccccact 5171 gggacacaag ttcagagaag ggcagagctg gctgcctgtc cagtgcttct ttcactccac 5231 cacctacagc tggccgctga gggagcattc acatgtgact ctgtccccag ggactccgat 5291 cttgccttaa agtcctccag ggcctctggg gatgggggca cagccttcac cctcaccccc 5351 tccctggatt ttatagccca cttaccatgc ataacagaca agtcccat 5399 <210> 12 <211> 5472 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (207)..(665) <400> 12 gtccggtgct caggcctgct ggccagcccc gagcttccaa agatacagca tgcaagggga 60 ggaggcacgg gctgcgctgc tccgtccctc tttcattcca caggaggtaa agctgtccat 120 tgaagggcgt tccaatgcgg gaaaatgaac ctcttcccca gaccaggact ggggctttac 180 cccagagcct cgcctcgccg ccgtga gca ggc aga gga ttt gca cac gcc gag 233 Ala Gly Arg Gly Phe Ala His Ala Glu 1 5 cag gga atg gct ttc ttg gca gtg aga ttt ggg gga aag ggg agg cat 281 Gln Gly Met Ala Phe Leu Ala Val Arg Phe Gly Gly Lys Gly Arg His 10 15 20 25 gaa gtc agc ctc cca agg cag gat ctg ttg ttc att acc cca tgg cat 329 Glu Val Ser Leu Pro Arg Gln Asp Leu Leu Phe Ile Thr Pro Trp His 30 35 40 cct ttc agg aca acc cca gag ggt gtt gtg atg ggg agc agc agg cct 377 Pro Phe Arg Thr Thr Pro Glu Gly Val Val Met Gly Ser Ser Arg Pro 45 50 55 ggg gca agg aag gaa ggg ggt gca cac agg aga aga aac att cca aaa 425 Gly Ala Arg Lys Glu Gly Gly Ala His Arg Arg Arg Asn Ile Pro Lys 60 65 70 tca ggg cct ccc tgt tct ttc ctc ccc atc cct agc tcc tgc aag aga 473 Ser Gly Pro Pro Cys Ser Phe Leu Pro Ile Pro Ser Ser Cys Lys Arg 75 80 85 aag tcc agg ctt tgg gag cag atg gca gag gga ggg agt aaa gaa aga 521 Lys Ser Arg Leu Trp Glu Gln Met Ala Glu Gly Gly Ser Lys Glu Arg 90 95 100 105 gcc aaa aat gat gat cca cag ctt ata gta gca gtt aaa ctg tca gaa 569 Ala Lys Asn Asp Asp Pro Gln Leu Ile Val Ala Val Lys Leu Ser Glu 110 115 120 gtt ttt ttt ctt ttt tgt ggt aga agg gca gga ggc ccc aag gtt gga 617 Val Phe Phe Leu Phe Cys Gly Arg Arg Ala Gly Gly Pro Lys Val Gly 125 130 135 aat aag agg gtt ccc acc cag aac cct tct tgt gag aga tgc gca ctt 665 Asn Lys Arg Val Pro Thr Gln Asn Pro Ser Cys Glu Arg Cys Ala Leu 140 145 150 taaagggtga ttttgttcca gatgtctatg gctgggtgtg tgggggagga gcactctcat 725 ctgcaggact ctgcttgatc ctctgcttca tagcccttcc ccatctctcc tcaccattct 785 gcctacaagg cttctagcag cacgggggcc cggagggaga gccccttcag ggttcagagt 845 gaagtactac cttgccaggg actcagtcag gggactttgg gagaaagact tgatagccag 905 gctgactggg ttctaggcag gccctctgga aaggtagctc acctaacaaa gctcctccaa 965 ctcagcatgc cagacccact ttgaaatctc acagaatctt gctggtaatg gtgactttag 1025 aactagtaga ccctttttcc caggcactga ccccccacct ttgtctgtgt tgtgcccaag 1085 tgcctgcgcc acccccaccc tcctgctgcg ctgaccgctg catggtgtcg tgacctgggc 1145 ctcatttgta gctgcactgc ctttccttgt ctgcaaagtt ggttttgtcc actctgacca 1205 agacctctag tttttggtgg gtagggggtc tctctggttt ccccttcagc tataatctct 1265 atttttaaaa tctcaaaatc atgtcccctc cacttccact gccaaacagc ttggtgaaga 1325 aacaagaagg gaactatgcc ctgggccagg gcgaatgcgt ggctgggcag tgcccatcat 1385 ggcattttca catgtcccat atgcccctcc tgtcttattc cactgcttct cccagcattc 1445 tggtgcctcc aagccatccc ctcccaccac cagctctaag attctaggat agtcttgata 1505 acatttcagt acctgaatag atgtcatttt gtgttggtat attcctctgc aaaaagtatt 1565 ttcaatcttg gttgcattgg caccccccct accccccacc aatgtcttaa tcccacattt 1625 tcttcacaac ttttagcatc agctcagacc gtggggttcc actgggtatt gggaattagg 1685 ctcccccact agctttcagg tgggtaagtt tttttgtttg ttttttgggg gtctttagac 1745 tcttgaaggc aactcagggt attgtccacg cagctctctg gttagacttc tcccaggcta 1805 tgatcctggc atgtccttta taaggtatac ttggattggc cgagacctgg cctggcatca 1865 ggagtccaaa cctctgaggt ctgatctctg ctctgtcaag gactttcggc aagtctcgtg 1925 acctctggct ctttcacttc ctccccacct gccaaatggg gataaataat cttacctacc 1985 tcctgggggg aggggaagtt ctgagaatgg agtcattctt agtgttcagg tgctaaaggt 2045 tgttctcctg ggggaacaga gtgactgaaa ctggcttgtt tgctacaagc cctaccctcc 2105 actctttcat tccttgaaag cagtttgcct ggtcagtcag cttttggggg tccatcaaag 2165 gaggttgctg acctgaccgt gagtgcttca gtatctggtt tgtgtcagaa ccagacgcca 2225 actttgtact gcatttggga tcatatcttt ccccttctct gtcccccatt ctctgaatgc 2285 tgctttctct ggcttgtttc ctacagtggg ggcctgtggg gttgagtctt gaggaatccc 2345 ctcaaatgag aaggccttgg gagaaggcct catctctggc tgtttcatga gcaactcatt 2405 cctagagttc attgtttgca tgggtttctc acaagcgtcc ttcctcatag gaaggctcat 2465 caactgaatt tagtgacatg tacacagtag atgctcaagc agtgtctgca aggacacaag 2525 ctgagctttc tccttatggg gcaaacctat gtctaaccag atacagacca attagtttag 2585 atcaaatcac cttccacttg ggctacttgt gactttccaa cctggtaact tccactgaat 2645 tctggaaaga gaaattcttg aggaccctgg caagttgggc cctgaccttt ctgttgctgt 2705 ctcttgctgg tgaagcaata ccagcagttc ctgtaatacc acaatatcgt tccatgcata 2765 tataacatat taatacttga ttttgctgag ctgcaaaggt atctgtcata aaatatggtc 2825 cccaggaaaa gaatctctgt gctctaaatc tcggtcagag ctgtggcctc ccccttgcct 2885 ttaacctcta gtttagtctt ttcctccagg catgaaaaat atgactaacc tgtggtgtgt 2945 ccattcttcc ttataggaat ttcctgagtt tgcaggagac atgagagcag tttttagcga 3005 gtattttagt gggaagttgc caacttttta agaatgagca gttgacaagg gccagagcct 3065 gtcccttgtc agcagtagga catttccagc tcttaggaat agaaaggagg actgctgact 3125 gtctggcgct gtataaaaat gtgtatacca atttgggaat aggggaaccc agtcatggat 3185 ggataataag ccaagtcttg aatcattcct atcaagatta gtatacatga ggaagaggtg 3245 gcatgggggg aaggggctct gggagttcag agctgagtac ttgtacctga gggagggccc 3305 ccagccaatc tgggctggtc cttctatatt cttggtccca gttggtcata acaccaaggg 3365 ctttgccctg cgctgctttg ccactgctgc tgtccgctca ctgtcctgcc tgctgtcctc 3425 tacagctccc tatccttcca tgtctttggc catgtagatt aagtgtaggc gtccggttca 3485 ttcttacctg tgttaggcca tgttatttta tagcgaagtc atgttcgata gggatggtat 3545 gaaatgctgc tggtgggctg gtaaatccaa agggataagg cttcagtgct gttgggagcc 3605 ctttggctcc aaatgtctga ctatcttgag ggagaaacaa gcaggtttct actagtggtg 3665 tcttctgttg tattaacttc tttcctttgt ggtatcttgt atcctgtttt aaaaactaaa 3725 tgaagggaac cacattaggg cccatgccag catcccagtg aagttcgtcc agctccagtt 3785 aggtggattc tggagttcgg agagggttta aagtttggct gaaatagcac ctcaagtggg 3845 gtttagtttt atttttacct gcgggcatca tgggcgattt agggggaagc acaggatggt 3905 ggtgtggttt aaacctgcag caagcaggca tgttgaagag ttgagtgatc acgctggaga 3965 tgaagggttg gacatggatt gactgggaaa aggcctgggt ccattggagt aaagataacc 4025 tagtcgattg aattggccat gggaagttag gtcacagtct tataaacaaa gtaaatagga 4085 cagagactaa gttttaggga gacatcttgg cctcctaggc taagtttact aaaccacact 4145 gaagctatag taccttccag atgggcaaaa gtgtacacta cagttgagga gctgaacctt 4205 attaggttgg atgtcgatca ggaacctgtt tgccctttgc tgggaagcct tcactctcca 4265 gctttcctgg ggtagggaag gtctcccaca ttatgcaata ataaaataag catctgggtc 4325 tttgcagctg tcagttgctc tttcaactct aggatccatc tttggaccag aagcctggtc 4385 tgtgcctagg atgacactgg ccccagagat gctagagtcg actgcactct ctccttagct 4445 gcagaccatg cacagtgcct ggggcggaag gaggagaggt gttgcggttt gccctgctgc 4505 ctccccagca ggaacaatag tcataaatgc acttttcaca ctaaaggttt ctttattagt 4565 tctccagtta aacctagatc cctccctggt agattgcgaa ctcaaagttt tgtgatccca 4625 aagccattcc actgcaaatg cccagcagtg aagatggcct caaattgggt tcttgcctgc 4685 agtgtgtgtg gcagcagccc atgtgccttt acctgttgtc aaacttgcaa gcatttattt 4745 gtctttatga ctgtcatggg gactgaggtt cttcagagaa agagtgtgag ctgatgacac 4805 agtggtttta cacccacccc ctgggcaggg agtttgcacg tagttgtgag ctgtgagtgg 4865 ttagtgcatt gctggtattg ctgaaggcag ggttgatccc tcacttgact gatacttgca 4925 ttcaagagaa tctagattgt gttgggggag ggactgactg tactcatggc taacttaaaa 4985 tattaaaata aggctgtccc ctacaacctt cttagtcaca caggatccct gtagccaaaa 5045 cagtatatga tccagctgca gagagcagac tgctctcagc ttgcacagca ccttaggcga 5105 gggaagaata tacggatagg gaatggggtg gagaaaggat gggaatgttg tcatccaggt 5165 ggctttaggg tcctaaggag tggagaagga tggcactggg gaggtctgga tggatctgtg 5225 taggagttcc ctgtagataa attactgatc ccccatctac tatccccagt atgtaatggc 5285 tgaattaata tgtaatcaac tgcattgtat ctaaagcctt agaactagtc aggtgctccc 5345 tccacccaat accatttctt accctctaat cctacctgat ctttaacaaa gcattaataa 5405 ttctaaggat aatctctatt ttgttgtgct tttttgtaac tgttttaaat aaatcaattt 5465 gtactgt 5472 <210> 13 <211> 5546 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(1201) <400> 13 g ttg aca tct aca gcc ttt gga aac atg gac aaa ttt ccc ttc aac tgg 49 Leu Thr Ser Thr Ala Phe Gly Asn Met Asp Lys Phe Pro Phe Asn Trp 1 5 10 15 aaa ttg aaa tcc cac atc ctt gac agc tcc atc tac tcc aac aga ccc 97 Lys Leu Lys Ser His Ile Leu Asp Ser Ser Ile Tyr Ser Asn Arg Pro 20 25 30 aaa gtg cag acc ttg ttt tat gtc act ggc atg ggc tgg gat gac agc 145 Lys Val Gln Thr Leu Phe Tyr Val Thr Gly Met Gly Trp Asp Asp Ser 35 40 45 gac ctt acg gaa gat cta ccc tgt gtc aag atg ttt gct ttc cct gag 193 Asp Leu Thr Glu Asp Leu Pro Cys Val Lys Met Phe Ala Phe Pro Glu 50 55 60 gcc agg gaa gtg gca gcc agc tgt cgg ctg caa ggg gcc cca ggg ctg 241 Ala Arg Glu Val Ala Ala Ser Cys Arg Leu Gln Gly Ala Pro Gly Leu 65 70 75 80 tgt gtg gct gag ctg gag ctg ctg ccc gag tgg ttc agc tca ggc ctg 289 Cys Val Ala Glu Leu Glu Leu Leu Pro Glu Trp Phe Ser Ser Gly Leu 85 90 95 gac ctg gaa cca gag gag gag atc cca gcc ctg ctc ggg ggc acc acg 337 Asp Leu Glu Pro Glu Glu Glu Ile Pro Ala Leu Leu Gly Gly Thr Thr 100 105 110 atg gag ctc ttc ttc acg ctc tac cca gct gac aag gct ggc cag tgt 385 Met Glu Leu Phe Phe Thr Leu Tyr Pro Ala Asp Lys Ala Gly Gln Cys 115 120 125 cct ctg gag gag gaa ggc aag tgg gag aac aat atc cac tcg ggc ctg 433 Pro Leu Glu Glu Glu Gly Lys Trp Glu Asn Asn Ile His Ser Gly Leu 130 135 140 gag agc ccc cag caa gcg ttt cca gcc cga gag agg att ggg agt gtg 481 Glu Ser Pro Gln Gln Ala Phe Pro Ala Arg Glu Arg Ile Gly Ser Val 145 150 155 160 gtg gtc tac cca acc caa gat gat ctg aag tgg tcc ctg gtg agc ttg 529 Val Val Tyr Pro Thr Gln Asp Asp Leu Lys Trp Ser Leu Val Ser Leu 165 170 175 gac gag aat gtg gtc atc tcg gta cct ctg aat cta gtc cgg gaa ggg 577 Asp Glu Asn Val Val Ile Ser Val Pro Leu Asn Leu Val Arg Glu Gly 180 185 190 gac acg gcc acc ttt ttg gtc tct ctg acc agt agc tct gtg gca gac 625 Asp Thr Ala Thr Phe Leu Val Ser Leu Thr Ser Ser Ser Val Ala Asp 195 200 205 cag ttc act ctt aga att aag gcg gca gca ggt gtg aag ata acg gca 673 Gln Phe Thr Leu Arg Ile Lys Ala Ala Ala Gly Val Lys Ile Thr Ala 210 215 220 gtg aga gtc agc agt gag gac caa tgg gca gtc cag gag gaa att gat 721 Val Arg Val Ser Ser Glu Asp Gln Trp Ala Val Gln Glu Glu Ile Asp 225 230 235 240 aat ggc agc act cag acg tcg gcc acc ctc acc tgc atg ggc cat cgc 769 Asn Gly Ser Thr Gln Thr Ser Ala Thr Leu Thr Cys Met Gly His Arg 245 250 255 ccg gac acg cag agc agg gta aat gga tcc ttc tat gag atc ttg caa 817 Pro Asp Thr Gln Ser Arg Val Asn Gly Ser Phe Tyr Glu Ile Leu Gln 260 265 270 gtg gac ttt gga att gat aat agc agt gac ctg gct ggg gcc cag cag 865 Val Asp Phe Gly Ile Asp Asn Ser Ser Asp Leu Ala Gly Ala Gln Gln 275 280 285 att acc tgg cag gtg gag tac ccg att gag gac tcc atg agt gag ctg 913 Ile Thr Trp Gln Val Glu Tyr Pro Ile Glu Asp Ser Met Ser Glu Leu 290 295 300 gtc gtc tcc gag atc ttc gtc agc cag aca acc ttc gtg ggc atc gtc 961 Val Val Ser Glu Ile Phe Val Ser Gln Thr Thr Phe Val Gly Ile Val 305 310 315 320 cct ctt gcc atg gac acc gag gtt ttg aac act gcc att ctc act gga 1009 Pro Leu Ala Met Asp Thr Glu Val Leu Asn Thr Ala Ile Leu Thr Gly 325 330 335 aag cct gtt tca gtt cct gtc aaa gtc gtg ggg gtc cag gag gat ggt 1057 Lys Pro Val Ser Val Pro Val Lys Val Val Gly Val Gln Glu Asp Gly 340 345 350 tct gtg gtc gat gtg tct gag tct gtg gaa tgc aag tct gcc gat gaa 1105 Ser Val Val Asp Val Ser Glu Ser Val Glu Cys Lys Ser Ala Asp Glu 355 360 365 gat gtc att aag gta agg ggg gat tta tct aca gct gtc cta agt gct 1153 Asp Val Ile Lys Val Arg Gly Asp Leu Ser Thr Ala Val Leu Ser Ala 370 375 380 cag agc ttt ttg tcg ttc ctt ctt ttg tct cca agg tct tgt tct cac 1201 Gln Ser Phe Leu Ser Phe Leu Leu Leu Ser Pro Arg Ser Cys Ser His 385 390 395 400 tgagcatccc atgctctaaa gggctggagg ccagaatgac ctcacgaagg aggaaacagc 1261 tgaccgcaga gactccctgg aatcagcagg cggctgcagc aggtgatgct gcttccctct 1321 ccctggaaag gggaatccct gacccttaat ctccagcaga aagaatttat tctcctcccc 1381 ttcttgtctc ccctattctt ctctctatct ttcctcgtaa gacaatattt tcctaacttt 1441 agcaatccaa ataagacctt ctcatttttt gcaaactcac tgtgcctaat aatattattt 1501 actcaatata ttttctttaa atgccttgct tctttcgggt agccagttag ctcagtgggt 1561 tagagtgtgg tgctaataaa tgcattactt tttcaaactt aaaaactaat ttagcttcat 1621 tataagacaa taaagtccgt gagcttggtg tattacattt tttgttaata tgcattaaaa 1681 taaataacta ttcaaataaa attaagttca cccatgtgcc acctaactga acttgaatat 1741 aaccagtggg atacagttta ggaaatggga catttctgct agattcttca ctcaaattag 1801 ctatgtttct gactccaaat tctgctagga accagaaaat atttttttca tgctctctga 1861 aggggtcttt ttgaaccacc aaatttaata tttctgccta ttttttctta gcacattggt 1921 tgctattgct tttgcagcag agacctcagg gagaaaggat ttgaattttt agaatgactg 1981 atccttcctc ctttaaatta ttaagagagc cccaaagtcc aatctattca gctattttag 2041 aaaaatacaa taactcagag ttctgccctt cctcacattc tacaagctct tgtttagagg 2101 ttacatgaaa cttggtctca gtattgaaaa cttcgtggta gacaggaaaa cctttagggg 2161 tttccctata gtagaaaagg tctgggaggg gttgatttct tcttgttgtg acctacagga 2221 tgctgtgtct taagcaagag acagtttcgg aaaaaaagac tgatgtattc gtgaggtcta 2281 attaacaaag aaattaattc ctaggaaact caagtttggc atagactctt tcctggacat 2341 ggaatgctca tcgtccttag atatggaagg tggactggct taaaacctgc acacatagcc 2401 ctgcctgggg ttcctggtgg tccttgtatt ctgtaggcag gtttgattaa atatatggcc 2461 ttaaatattc agagtttaga aagagctgag ccaagtcaca ggagattata tgcaccaatg 2521 acaaatatgg atgatgaact gctgttggtt gctattgaca atgcgcaagt tttacactat 2581 ttttactatt cccatgtcat tctagaaagg agacactgat aagagatggt atctgtatgc 2641 ttacgtcata atgggctcaa acaaatgatt cagtctgtag tttcctaagc cttttgttct 2701 gacctaagag cctgctatga agccccatgg ggtggaatcc tccttctctt gccctgaaga 2761 gctctactct agaggggcag gtccaagttc acagatcccg ttattgccat atacctggtt 2821 ttctccactc cacacaaatg tactaaaagt atcctctgct catcctcata gacgttgttt 2881 tggaagatga tacctttttg ctcagctgtc acctatatag cctcaggagg atggggattc 2941 gtctaacaaa ttattgccca gtcttcagag gaacaaagtg aaacctgcag atcgcaagct 3001 cagagctgta ttcacacttt ttaaggggat tccaggactg ttgcaagttt gggggcttgt 3061 gtcaattgag gcgatttaat taaatggctg tgatgcattt actatggctt cagtgtcaat 3121 gtttgtagta aattttacta taactccaag ttgaatggag ttgtccacag agctatgacc 3181 ttggcatcat cccagggaca tcctcaaata catggcacat tcattagcac cctttggaga 3241 gatcctctga gtctgtggag ttgtcacaca gtcatacttc agagtacaga aaacactgaa 3301 tgatttttag ggagagtctt gcagggctca ccaaagatct ttgtgccttg gaaccatgag 3361 ttagataagg gaaaaatgtg aatttagaaa gatgtaagtt atggtaatat ccaaacaaat 3421 gaacttgttt ggcctgtgat tgtatgactt ttgcgggaca gaatcagagg acatacatga 3481 ttttgaaaag ctggaacctt ggcctaatct ggcaagatta aaagagataa atgtaaaatt 3541 tcaagttgac aactatagta gtccttcctt atctgtggtt tcactttccg tggtttcatt 3601 tcactgtggt caatcacagt ccaaaaacgt taaatgaaaa ttttcagaaa gaagcaattc 3661 atgttttaaa ttgtgtactg ttctgagtat cgtgaagaaa tcttgagtct tcctgctcca 3721 tcccacctgg gttgtaactc atgactttgt ctggcatatc catgctgtag ataccaccca 3781 cctctgagtc atttagtagc tgcctgggtg atcaaataga ctgtcgcggt atcacagtgc 3841 ttgtgttcaa gtcaccctta tgttatttac aaatgacccc aaagtataag agtagtgatg 3901 ctggcaattc ggctagacca acaagaagtc ataaagtgct tcttttaagt gaaaaggtga 3961 gagttcttga cttaataagg aaggaaaaag atcatatgct ggagttacta agatctacag 4021 tcagagcgaa tcgtctatcc atgaaatcgt gatgaaggaa aaaacattca tcgtagtttt 4081 gctgtcacat ctcaaataca aaagttaagg ccacagtgtg tgataaattc ttcattaaga 4141 tgtgaaaaga cattaaattt aggtgaaaga catgaacaga aacttgttct gctggatgac 4201 agtctgattc agttctatct gtggtttcag gcatccactg ggggtcttag actatattac 4261 ccatggatgg gaggagactg ggagactgct gtacttttag gttaaaaaaa aaaaaaacaa 4321 gtagaggatt gtgtgtgtgt gtgtgtgtgt gtgtgcgcac acacacaaga agccttagcg 4381 tttttatcag tattgggatc cagtgagtca actgtttgat aaggctgcta caggttgatt 4441 tttattagca tgaatgggtg tgtgcctcag agcagaggtc acaggcaggc agtctgcaga 4501 ccagatctga cccagaagtg tgtggggggt gcggggaggg tctgcatagt ttaaaaattg 4561 ttacttaatt tgttgccccc atgtaaaaat tggcaagttc gcacagaaat ctggatttac 4621 agtttcttat gaaaaatcac aggaccaggt ggtcctgggt ctccatgatt tcctgtgaac 4681 ctcgtctgga gttgaagaga ggatgctcct ctgcataaaa cctgtgccct ccagctcact 4741 gtagtctcca ccactccctt ttgtctttca catggaggtt gaaggatatt tgtcatttct 4801 ggtcacactt gtgctcctag tttttgatag tggatttcag aggaaggtga gatatttttt 4861 gtactccagt ctctaaaaat aaataagcaa caaatgatag acttcactct ctcactctga 4921 tggagaattc tgtatctttc taggccgtaa gaagaacaat aaaaaattgg gttgtgctct 4981 gccaaaaagt gtctgagagg ctgaggactc ttgaaatcaa atcacaggag aaatgattga 5041 aggaagtgtg agtgttaagc ctattgatga gaagaaaagg ctcaggggtg aggtggagag 5101 ggagacatga cagctttttg taagtctttc aagggccatc atgtagaaga tggagtagct 5161 ttgtgctttt tagattccaa gaatggaagt tgaaaggtac cagttttagc tcaatataaa 5221 gaaaaagact gcagaggtag tgagttcttt ggttgagctt ccagacatgt gatgttgcta 5281 aagatcctga ctccaccttc ctcaccgttt gaccttgggc aaattactta ccatctctga 5341 gcctagtttc cttatctata aaatggggat ggtaatgata cagtggaaac gtacttttct 5401 agagatttgt tctaaagtca cagcaaacgg cagaactaac aataaccaaa ctactcccta 5461 atccttgaaa atccccagtc tcgctgggtc atccgagatt gcgccactgc accccagccc 5521 gggtgacaga gcgagactcc gtctc 5546 <210> 14 <211> 5185 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(4693) <400> 14 a gcg gag atg gcg gca ggg tcg ggt ggg agt ggg ggc tct ggg gga ggc 49 Ala Glu Met Ala Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly 1 5 10 15 cct gga ccg ggg ccg ggc ggg ggt ggg ggc ccc agc ggg agc ggc tca 97 Pro Gly Pro Gly Pro Gly Gly Gly Gly Gly Pro Ser Gly Ser Gly Ser 20 25 30 gga ccg ggg tcc aac ggg ggt ctg ggc agc ggc ggg gaa ctg cac ccg 145 Gly Pro Gly Ser Asn Gly Gly Leu Gly Ser Gly Gly Glu Leu His Pro 35 40 45 cgc act ggg cgc ttg gtg agc ctg tcg gcc tgt ggg cgt acg gcg cgg 193 Arg Thr Gly Arg Leu Val Ser Leu Ser Ala Cys Gly Arg Thr Ala Arg 50 55 60 cgg cag cag ccg ggc cag gag ttt aac cac ggg ctg gtg ttg agc cga 241 Arg Gln Gln Pro Gly Gln Glu Phe Asn His Gly Leu Val Leu Ser Arg 65 70 75 80 gaa ccc ttg cgc gat gga cgc gtc ttc acc gtc cgc atc gac cgc aag 289 Glu Pro Leu Arg Asp Gly Arg Val Phe Thr Val Arg Ile Asp Arg Lys 85 90 95 gtc aac tcc tgg agc ggc tcc att gag att ggg gtg aca gcg ctg gac 337 Val Asn Ser Trp Ser Gly Ser Ile Glu Ile Gly Val Thr Ala Leu Asp 100 105 110 ccc agt gtg ctg gac ttt cca agc agt gcc acg ggc ctg aag ggg ggc 385 Pro Ser Val Leu Asp Phe Pro Ser Ser Ala Thr Gly Leu Lys Gly Gly 115 120 125 tcg tgg gta gtg tcg ggc tgc tct gtg ctg aga gat gga cgc tct gtg 433 Ser Trp Val Val Ser Gly Cys Ser Val Leu Arg Asp Gly Arg Ser Val 130 135 140 ttg gag gag tat ggt cag gac ctg gac cag ctt ggt gaa ggg gac cgc 481 Leu Glu Glu Tyr Gly Gln Asp Leu Asp Gln Leu Gly Glu Gly Asp Arg 145 150 155 160 gtg ggc gtg gag cgc aca gtt gct ggg gag ctt cgg ctc tgg gtg aat 529 Val Gly Val Glu Arg Thr Val Ala Gly Glu Leu Arg Leu Trp Val Asn 165 170 175 ggg cgg gat tgc ggt gtg gct gcc aca ggc ctg ccc cct cgt gtc tgg 577 Gly Arg Asp Cys Gly Val Ala Ala Thr Gly Leu Pro Pro Arg Val Trp 180 185 190 gcc gtc gtg gac ctt tat ggc aag tgc acc cag atc acc gtg cta ccc 625 Ala Val Val Asp Leu Tyr Gly Lys Cys Thr Gln Ile Thr Val Leu Pro 195 200 205 cct gag cca ggc ttc agc ccc cct act ccc atc ccc aca cct ccc ctc 673 Pro Glu Pro Gly Phe Ser Pro Pro Thr Pro Ile Pro Thr Pro Pro Leu 210 215 220 gag ccc ttg gcc ccc act gaa gac tct gcc ttg gct gaa cag ggg acc 721 Glu Pro Leu Ala Pro Thr Glu Asp Ser Ala Leu Ala Glu Gln Gly Thr 225 230 235 240 tct gca gat gaa gcc ttc atg gtg tcc cca gcg cag gcc cgg ccg gag 769 Ser Ala Asp Glu Ala Phe Met Val Ser Pro Ala Gln Ala Arg Pro Glu 245 250 255 acg ttt cct aac agc ctt gag tcg cat aat gac ttt gcc aac atg gag 817 Thr Phe Pro Asn Ser Leu Glu Ser His Asn Asp Phe Ala Asn Met Glu 260 265 270 ctg tct gag gtg gtg agc aac acc atc ctg tct gcc tac aat gga ggg 865 Leu Ser Glu Val Val Ser Asn Thr Ile Leu Ser Ala Tyr Asn Gly Gly 275 280 285 ctc ctg aat gtg aac ctg agc tcc cca ccg gca ggg gaa ggc ctg gga 913 Leu Leu Asn Val Asn Leu Ser Ser Pro Pro Ala Gly Glu Gly Leu Gly 290 295 300 tct agc ggt gct gcc acc tcg ccc att ctc act tcc aac gat gcc ctg 961 Ser Ser Gly Ala Ala Thr Ser Pro Ile Leu Thr Ser Asn Asp Ala Leu 305 310 315 320 ctc ttt cat gaa aag tgc ggg acc ctc atc aaa ctc agc aac aat aat 1009 Leu Phe His Glu Lys Cys Gly Thr Leu Ile Lys Leu Ser Asn Asn Asn 325 330 335 aag acg gct gag cgc cgg cgg ccc ctg gat gaa ttc aac aat ggg gtt 1057 Lys Thr Ala Glu Arg Arg Arg Pro Leu Asp Glu Phe Asn Asn Gly Val 340 345 350 gtc atg acc aat cgc ccc ctt cgg gac aat gag atg ttt gag atc cgt 1105 Val Met Thr Asn Arg Pro Leu Arg Asp Asn Glu Met Phe Glu Ile Arg 355 360 365 atc gac aag ctt gtt gat aag tgg tca ggc tcc att gag att ggg gtc 1153 Ile Asp Lys Leu Val Asp Lys Trp Ser Gly Ser Ile Glu Ile Gly Val 370 375 380 acc acc cac aac ccc aac agt ttg gag tac cca gcc acc atg acc aac 1201 Thr Thr His Asn Pro Asn Ser Leu Glu Tyr Pro Ala Thr Met Thr Asn 385 390 395 400 ctc cag tca ggc acc atc atg atg agc ggc tgt gga atc ctg acc aat 1249 Leu Gln Ser Gly Thr Ile Met Met Ser Gly Cys Gly Ile Leu Thr Asn 405 410 415 ggc aag ggc acc cgc cgg gag tac tgc gaa ttc agt ctg gat gag ttg 1297 Gly Lys Gly Thr Arg Arg Glu Tyr Cys Glu Phe Ser Leu Asp Glu Leu 420 425 430 cag gag ggt gac cac att ggc ctc aca agg aag tcc aac tct gcc cta 1345 Gln Glu Gly Asp His Ile Gly Leu Thr Arg Lys Ser Asn Ser Ala Leu 435 440 445 cac ttc ttc att aat ggt atc gat cag gga gtg gca acc ccc ttg acg 1393 His Phe Phe Ile Asn Gly Ile Asp Gln Gly Val Ala Thr Pro Leu Thr 450 455 460 ccc cca gtg gtg tat ggt gtg gtg gac ttg tac ggg atg gca gtg aag 1441 Pro Pro Val Val Tyr Gly Val Val Asp Leu Tyr Gly Met Ala Val Lys 465 470 475 480 gtg acc atc gtc cac aat aac aac cac agt gac cgt ctc cgc cga aac 1489 Val Thr Ile Val His Asn Asn Asn His Ser Asp Arg Leu Arg Arg Asn 485 490 495 aac gcc atc ctg cgg gcg ctg tcc ccc gag ggt gct ctc cgc cgt gct 1537 Asn Ala Ile Leu Arg Ala Leu Ser Pro Glu Gly Ala Leu Arg Arg Ala 500 505 510 gcc cct gcc gcc cag gca gaa cct gag cgc ctg ctc ttc cac ccc aac 1585 Ala Pro Ala Ala Gln Ala Glu Pro Glu Arg Leu Leu Phe His Pro Asn 515 520 525 tgt ggg cag aag gca gcc atc acc cac gag gga cgc act gcc ctg agg 1633 Cys Gly Gln Lys Ala Ala Ile Thr His Glu Gly Arg Thr Ala Leu Arg 530 535 540 ccc cat gcc acc gat gac ttc aat cac ggc gtg gtg ctg agc agc aga 1681 Pro His Ala Thr Asp Asp Phe Asn His Gly Val Val Leu Ser Ser Arg 545 550 555 560 gcc ctg cgg gat gga gag gtg ttc cag gtg cgc atc gac aag atg gtg 1729 Ala Leu Arg Asp Gly Glu Val Phe Gln Val Arg Ile Asp Lys Met Val 565 570 575 gac aaa tgg gct ggc tcc att gaa att ggt gtc acc acc cac aac cct 1777 Asp Lys Trp Ala Gly Ser Ile Glu Ile Gly Val Thr Thr His Asn Pro 580 585 590 gcc tac ctc cag ttg ccc tcc acc atg acc aac ttg cgc tct ggg acc 1825 Ala Tyr Leu Gln Leu Pro Ser Thr Met Thr Asn Leu Arg Ser Gly Thr 595 600 605 tgg atg atg act ggg aat ggg gtg atg cac aat ggg acg acc atc ctg 1873 Trp Met Met Thr Gly Asn Gly Val Met His Asn Gly Thr Thr Ile Leu 610 615 620 gat gaa tac ggg cac aat ctg gac cgc ctc aag gca ggg gac acg gtg 1921 Asp Glu Tyr Gly His Asn Leu Asp Arg Leu Lys Ala Gly Asp Thr Val 625 630 635 640 ggc gtg gta cgg cgg gag gac ggg act ctc cac ttc ttt gtc aat ggg 1969 Gly Val Val Arg Arg Glu Asp Gly Thr Leu His Phe Phe Val Asn Gly 645 650 655 atg act cag ggc cct gct gcc tgg aac gtg ccc ccg ggc gtc tat gct 2017 Met Thr Gln Gly Pro Ala Ala Trp Asn Val Pro Pro Gly Val Tyr Ala 660 665 670 gtc gtc gat ctc tat ggc cag gcg gcc cag gcc acc att gtg gac gac 2065 Val Val Asp Leu Tyr Gly Gln Ala Ala Gln Ala Thr Ile Val Asp Asp 675 680 685 gtg gag gtg gct cca gtt cct gaa cca ctc cct gag ggg aac aac cag 2113 Val Glu Val Ala Pro Val Pro Glu Pro Leu Pro Glu Gly Asn Asn Gln 690 695 700 gtg tct cca agc tct ccg tcc tca ggg gcc ggg ggc tct gac ctg cgc 2161 Val Ser Pro Ser Ser Pro Ser Ser Gly Ala Gly Gly Ser Asp Leu Arg 705 710 715 720 ttc cat cag ctg cac ggc agt aac gca gtc atc act aac ggg ggc cgc 2209 Phe His Gln Leu His Gly Ser Asn Ala Val Ile Thr Asn Gly Gly Arg 725 730 735 acc gcc ctc cgc cac aac tgt cgc agc gag ttt aat gac gcc atc gtc 2257 Thr Ala Leu Arg His Asn Cys Arg Ser Glu Phe Asn Asp Ala Ile Val 740 745 750 atc tcc aac cgg gcc ctg cgg gat gga gag ctg ttt gaa att gtc att 2305 Ile Ser Asn Arg Ala Leu Arg Asp Gly Glu Leu Phe Glu Ile Val Ile 755 760 765 cag aag atg gtg gac cgc tgg tca ggc tcc att gag gct gga gtg act 2353 Gln Lys Met Val Asp Arg Trp Ser Gly Ser Ile Glu Ala Gly Val Thr 770 775 780 gct att cgg cct gaa gac ctg gaa ttc ccc aac acc atg aca gac att 2401 Ala Ile Arg Pro Glu Asp Leu Glu Phe Pro Asn Thr Met Thr Asp Ile 785 790 795 800 gac tat gac aca tgg atg ctg agt ggt aca gcc atc atg caa gac ggt 2449 Asp Tyr Asp Thr Trp Met Leu Ser Gly Thr Ala Ile Met Gln Asp Gly 805 810 815 aac acg atg cgc aac aat tat ggg tgt gac ctg gat gcg ctg ggc aca 2497 Asn Thr Met Arg Asn Asn Tyr Gly Cys Asp Leu Asp Ala Leu Gly Thr 820 825 830 ggt gca cgc att ggc atg atg cga act gcc aag ggc gac ctg cac tac 2545 Gly Ala Arg Ile Gly Met Met Arg Thr Ala Lys Gly Asp Leu His Tyr 835 840 845 ttc atc aac ggc cag gac caa ggc gct gcc tgc tcg ggc ctg cct ccg 2593 Phe Ile Asn Gly Gln Asp Gln Gly Ala Ala Cys Ser Gly Leu Pro Pro 850 855 860 ggt aaa gag gtg tat gcg gta gtc gat ctc tat ggc cag tgt gtc caa 2641 Gly Lys Glu Val Tyr Ala Val Val Asp Leu Tyr Gly Gln Cys Val Gln 865 870 875 880 gtg tcc atc acc aat gcc acc ggc ccc atg gac aac agc ctg gcg acc 2689 Val Ser Ile Thr Asn Ala Thr Gly Pro Met Asp Asn Ser Leu Ala Thr 885 890 895 agc aac act gcc acc gag aag tcc ttc cca ctg cac tcc cca gtg gct 2737 Ser Asn Thr Ala Thr Glu Lys Ser Phe Pro Leu His Ser Pro Val Ala 900 905 910 ggc gtg gct cac cga ttc cac agt act tgc ggc aag aac gtc act cta 2785 Gly Val Ala His Arg Phe His Ser Thr Cys Gly Lys Asn Val Thr Leu 915 920 925 gag gag gat ggc acg agg gca gtg cgt gcc gct ggc tat gct cat ggc 2833 Glu Glu Asp Gly Thr Arg Ala Val Arg Ala Ala Gly Tyr Ala His Gly 930 935 940 ctt gtc ttc agt acc aag gag ctg agg gct gag gaa gtc ttt gag gtg 2881 Leu Val Phe Ser Thr Lys Glu Leu Arg Ala Glu Glu Val Phe Glu Val 945 950 955 960 aaa gtg gaa gag cta gat gag aag tgg gca ggt tcc ctg cgg ctg ggg 2929 Lys Val Glu Glu Leu Asp Glu Lys Trp Ala Gly Ser Leu Arg Leu Gly 965 970 975 ctg acc aca cta gca ccg ggg gag atg gga ccc ggg gca ggc ggt ggt 2977 Leu Thr Thr Leu Ala Pro Gly Glu Met Gly Pro Gly Ala Gly Gly Gly 980 985 990 ggc cca ggg ctg cct cct tcc ctg cca gag ctc cgg acg aag acc act 3025 Gly Pro Gly Leu Pro Pro Ser Leu Pro Glu Leu Arg Thr Lys Thr Thr 995 1000 1005 tgg atg gta tcc agc tgt gaa gtg agg cgt gat ggg cag ctc cag agg 3073 Trp Met Val Ser Ser Cys Glu Val Arg Arg Asp Gly Gln Leu Gln Arg 1010 1015 1020 atg aac tat ggc cgg aac cta gag agg ctg ggg gtg ggg agc cgt gtg 3121 Met Asn Tyr Gly Arg Asn Leu Glu Arg Leu Gly Val Gly Ser Arg Val 1025 1030 1035 1040 ggt gtt cgt cgg ggg gca gat gac acg atg cac atc ctg gtg gat gga 3169 Gly Val Arg Arg Gly Ala Asp Asp Thr Met His Ile Leu Val Asp Gly 1045 1050 1055 gag gat atg ggg cct gca gcc act ggc att gcc aag aac gtg tgg gct 3217 Glu Asp Met Gly Pro Ala Ala Thr Gly Ile Ala Lys Asn Val Trp Ala 1060 1065 1070 gtg ttg gat ctc tac ggg cca gtc cgc ggt gtg tca att gtc agt tcc 3265 Val Leu Asp Leu Tyr Gly Pro Val Arg Gly Val Ser Ile Val Ser Ser 1075 1080 1085 acg aga ctg gag gag tca gaa ggc acc cag cct cct tcc ccc agt tca 3313 Thr Arg Leu Glu Glu Ser Glu Gly Thr Gln Pro Pro Ser Pro Ser Ser 1090 1095 1100 gac acc ggc agt gag ggc gag gag gat gac gag ggc gag gag cat ggc 3361 Asp Thr Gly Ser Glu Gly Glu Glu Asp Asp Glu Gly Glu Glu His Gly 1105 1110 1115 1120 ctg gga ggc cag aat gaa gtg ggt att ata ccc acc acc ctc gag ttc 3409 Leu Gly Gly Gln Asn Glu Val Gly Ile Ile Pro Thr Thr Leu Glu Phe 1125 1130 1135 ctg gag aac cat ggg aag aat atc ctt ttg tct aat ggg aac cgt acg 3457 Leu Glu Asn His Gly Lys Asn Ile Leu Leu Ser Asn Gly Asn Arg Thr 1140 1145 1150 gcc aca cgg gtg gcc agc tac aat cag ggc atc gtt gtc atc aac caa 3505 Ala Thr Arg Val Ala Ser Tyr Asn Gln Gly Ile Val Val Ile Asn Gln 1155 1160 1165 cct ctg gtg ccc cag ctg ctg gtg cag gtg cgg ata gat ttc cta aac 3553 Pro Leu Val Pro Gln Leu Leu Val Gln Val Arg Ile Asp Phe Leu Asn 1170 1175 1180 cga cag tgg aca tct tcc ctt gtc ctg gga gtc atc acc tgc gcg cct 3601 Arg Gln Trp Thr Ser Ser Leu Val Leu Gly Val Ile Thr Cys Ala Pro 1185 1190 1195 1200 gag agg ctc aac ttc cct gct tct gcc tgt gcc ctc aaa cgg gca gcc 3649 Glu Arg Leu Asn Phe Pro Ala Ser Ala Cys Ala Leu Lys Arg Ala Ala 1205 1210 1215 tgg ctg ctg cgg ggc cgt ggg gtc ttc cac aac ggt ctc aag atc tgc 3697 Trp Leu Leu Arg Gly Arg Gly Val Phe His Asn Gly Leu Lys Ile Cys 1220 1225 1230 gag aag ttt ggg ccc aat ctg gac acg tgc cct gaa ggc acc atc ctg 3745 Glu Lys Phe Gly Pro Asn Leu Asp Thr Cys Pro Glu Gly Thr Ile Leu 1235 1240 1245 gga ctg cgg ctg gac agc tct ggg ggg ctg cat ctt cat gtt aat ggg 3793 Gly Leu Arg Leu Asp Ser Ser Gly Gly Leu His Leu His Val Asn Gly 1250 1255 1260 gtg gac cag ggg gta gct gtg cca gat gtg ccc cag ccc tgc cat gcg 3841 Val Asp Gln Gly Val Ala Val Pro Asp Val Pro Gln Pro Cys His Ala 1265 1270 1275 1280 ctt gtg gac ctc tat ggg cag tgt gag cag gtg aca atc gtg aac cct 3889 Leu Val Asp Leu Tyr Gly Gln Cys Glu Gln Val Thr Ile Val Asn Pro 1285 1290 1295 gag cca ggg gct gcc agt ggg aaa agt gct gga acc caa ggg gac atg 3937 Glu Pro Gly Ala Ala Ser Gly Lys Ser Ala Gly Thr Gln Gly Asp Met 1300 1305 1310 gag aaa gca gac atg gtg gac ggt atc aaa gag agt gtg tgc tgg ggt 3985 Glu Lys Ala Asp Met Val Asp Gly Ile Lys Glu Ser Val Cys Trp Gly 1315 1320 1325 cca cca cct gcc gct agt cct cta aag agc tgc gag tac cat gcc ctt 4033 Pro Pro Pro Ala Ala Ser Pro Leu Lys Ser Cys Glu Tyr His Ala Leu 1330 1335 1340 tgc tct cgc ttc caa gaa ctc ctg ctg ctt ccc gaa gat tat ttc atg 4081 Cys Ser Arg Phe Gln Glu Leu Leu Leu Leu Pro Glu Asp Tyr Phe Met 1345 1350 1355 1360 cct ccg cca aag cga agc ctg tgc tac tgt gag tct tgc cgg aag ctg 4129 Pro Pro Pro Lys Arg Ser Leu Cys Tyr Cys Glu Ser Cys Arg Lys Leu 1365 1370 1375 cga gga gac gag gcc cac agg cgc aga ggg gag cct ccc cgg gaa tat 4177 Arg Gly Asp Glu Ala His Arg Arg Arg Gly Glu Pro Pro Arg Glu Tyr 1380 1385 1390 gca ctg ccc ttt ggc tgg tgc agg ttc aac ctc aga gtg aat ccc cgc 4225 Ala Leu Pro Phe Gly Trp Cys Arg Phe Asn Leu Arg Val Asn Pro Arg 1395 1400 1405 ctg gag gct ggg aca cta acc aag aag tgg cac atg gca tat cac ggg 4273 Leu Glu Ala Gly Thr Leu Thr Lys Lys Trp His Met Ala Tyr His Gly 1410 1415 1420 agc aat gtt gcc gct gta cgg aga gtg ctg gac cga ggg gag ctg gga 4321 Ser Asn Val Ala Ala Val Arg Arg Val Leu Asp Arg Gly Glu Leu Gly 1425 1430 1435 1440 gca ggt act gcc tcc atc ctg agc tgc cgt cct ttg aag gga gaa cct 4369 Ala Gly Thr Ala Ser Ile Leu Ser Cys Arg Pro Leu Lys Gly Glu Pro 1445 1450 1455 ggg gta ggg ttc gag gag cct ggc gag aac tgt gca cct cct cgg gag 4417 Gly Val Gly Phe Glu Glu Pro Gly Glu Asn Cys Ala Pro Pro Arg Glu 1460 1465 1470 gag cag ccc cct cct gtg ctg ctt tcc ccc tcc ctt caa tat gct ggg 4465 Glu Gln Pro Pro Pro Val Leu Leu Ser Pro Ser Leu Gln Tyr Ala Gly 1475 1480 1485 gcg gag acc ctg gcc tcc aaa gtg caa ttc cgg gac ccc aaa tcc cag 4513 Ala Glu Thr Leu Ala Ser Lys Val Gln Phe Arg Asp Pro Lys Ser Gln 1490 1495 1500 cgg acg cac cag gct cag gtg gcg ttc cag gtg tgt gtg cgc cct ggc 4561 Arg Thr His Gln Ala Gln Val Ala Phe Gln Val Cys Val Arg Pro Gly 1505 1510 1515 1520 tcc tac acc ccg gga ccc cct tcc gct gcc ctt gga gaa cct cct gac 4609 Ser Tyr Thr Pro Gly Pro Pro Ser Ala Ala Leu Gly Glu Pro Pro Asp 1525 1530 1535 cct cac ttc agt cca gcc gaa ctt gag tgg gtc act aag gag aag ggg 4657 Pro His Phe Ser Pro Ala Glu Leu Glu Trp Val Thr Lys Glu Lys Gly 1540 1545 1550 gcc aca ctc ctc tgt gcc ctg ctg gta cgg gtg gaa tgaggggtga 4703 Ala Thr Leu Leu Cys Ala Leu Leu Val Arg Val Glu 1555 1560 gacaccacta ctacaagcac agtcgggccg cgggcccatg gactctgagt ggcgactgcc 4763 tccacctcat tcccgtgact cgtggcatgc gcaggtgctg gagcttggca gccgcgcagg 4823 agcatgtagg caggctctca gatgtaggtg gcaagtggca cagctccatg tccggaggcc 4883 cagcactccg tctgatggga ggagtcgtgg gagcccagct ccaggccctg gtacccctct 4943 tcatgcactg atttggggaa catgactccc ttttactccc ctaccccaca tcacttaatt 5003 tatttccgtt tttgtttctg gttactgtga atcccagagg agtctctccc tgtgcccaca 5063 tgaagctgct ttttccgggg ccaccgggcg ggagtgggga agggtgggcg cacggaagat 5123 gggggcctct gtacagttgt tactgactct gatttctaag gagccaataa acaccgtctc 5183 ag 5185 <210> 15 <211> 5776 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4489)..(4887) <400> 15 gaaattcaag attaatgttg gagaaacagt ataaagctct agtttttcag gctgtagaat 60 ataaaatcat cagacaaaac ctaaaaaggc aagatattag atgtaagaaa tgtcttgaaa 120 tgaatgtgaa gtgaattgaa aagagccgtg aataaagcaa aaaccactag gaattcaatt 180 ttgttggcta tttctgacat tcacaagtag acgtaccaga agaaataaaa tctaagaaga 240 gtttatcttc tacacaagtt atttccagca tctggcagtt catagcacaa agtaaacttc 300 tgcatatgtt tgtcagaata aactaaatcg tcttgttaat atactattga cactgatttt 360 cttaagaatg tagtaaaaaa gtaaatcatt cattaaaaaa aggaaaaaat agagaatggt 420 taagaccatg aagttgtaac tgaggaagat atttagattt tataagataa ggaacgattt 480 tagtttattc agtcattaca atggttcaac tgcatgcata tattaaaata ttattattat 540 gaacatttaa aaatgtatac aaaaataaaa cagtaaacag tttaatgtat ttagctccca 600 gcttcaagaa taatcaacat attctccaaa tttgtttcat attcttctcc acttttttca 660 tcttggacta gatgtttgaa gaaaatccta gatgtcatgc tgatatggtt ttaatgtgtc 720 cctatccaaa tctcatcttg aattctcaca tgttgtggga gggacccagt ggggggtact 780 tgaatcatgg gggcaagtct ttcccatgct gttctcatga cactgaataa gtctcatgag 840 atctgatggt tttataaaga tgaattcccc tgcacaagtt tcctctcttc gcctgccgcc 900 attcatgtaa gatgtgactt gctcctcctt gccttctgcc atgatagtga ggcttcccag 960 ccatgtggaa ctgtaagtcc aattaacttt ctttcttttg gaaattgccc agtctcaggt 1020 atgtctttat cagcagtgtg agaacagatt aatacagcaa attggtacta gtagagtggg 1080 gtgttgctta aaagattctt gaaaatgtgg aagcaatttt ggacctgggt aacagataga 1140 gggtgaaaca gttgggaggg ctcagaagaa gacaaggaaa tctgggaaag tttgaaactc 1200 cctagagact tgttgaatgg ctttgcccca aactgcttac aaggatatgg acaatgaatc 1260 caggctgaga tgatatcaga tggagatgag aaacttgttg ggaactggag caaatgtgac 1320 tcttgttatg ttttagcaaa gagactgatg gcattttgcc cctgccctag agatctgtgg 1380 aactttgaac ttgagagaaa tgatttaggg tatttggtga aagaaatttc taagcagcaa 1440 agtgttcaag aggtgacttg agtgctgtta aaagcattca gttttataag ggaagaagga 1500 catacaagtt cagaaaattt gcagcctgga aatgtgataa aaaagaaaaa ctcattttct 1560 gaggagaaat taaagccagc tgcagagatt tgcataagta agaaagagcc aaattttaat 1620 tcccaagaat atgggaaaaa tgtctccagg gcatgccaga ggtcttcatg gcagaacctc 1680 ccatcacagg tccaggggcc taggagaaaa tagtttcaat attgagtatg gtttaaatat 1740 tttatatttt acattttcaa atattgcagt tttattattt attttaaatt tcgccgtcat 1800 tatcacacag aaggaaattt gcaacatttt cttactgcca tctgtaaccc aaaataaacg 1860 tgccaattta tttcaaaatt cattttttac aatccattgg tttaaatcat gatccataag 1920 tcacacattg caattgattg ttgtcttgta agtcttttat aatctataac aactttgttt 1980 atctatgttt attttgttat gaattcatta tttgtctttt caaaaaaaca gatcattttg 2040 atacagtagg tagcttgtca ggcatgagca gggtaaggga gggctccctc ccccaaccag 2100 gaatgtcaag tgaccatcag gtcatggtca ggtggttgtt aaagtgtctc tctaaaataa 2160 taattggttg cagctggcac cagcaaaagg cagtctccca gcagaaagac aaaacctgaa 2220 acaggtgatc agcagcttcc cgataagatc acaggagttg gacaagtgtg ctcaagcatg 2280 catgttaaaa agcaaaatga tagagtttaa ctggtatatg accttctagg aaaattcagc 2340 tggtaaggga ataacacctc aaaagagcat acatacaact ttgtatgtat ttcattcttt 2400 ttttatggct gcatagtatt ccatggtgta tatgtatcac attttcttta ttcagtccat 2460 cactgatggg cacctaggtt gattccacgt ctttgccatt gtgaacagca caacaatgaa 2520 catatgagtc cacatgtctt tttggtataa tgatctgttt tccatactca gtaatgggat 2580 tcctaggtca agtggtagct ctgttttaag ttctctgaga aatctccaga ctgctttcca 2640 cagtgtgtga actatttgca ttcccaacga cggtgtataa gtgttcttta ttctctgcag 2700 cctctccagc atctgttgtt ttttgacttt tttttttgag atggagtttc cctcttgttg 2760 cccaggctgg ggtgcaatgg tttgatttcg ggtaactgca acctctgcct cctggtttca 2820 ggtgattctc ctgcctcagt ctccctagta gctgggattg caggcagatg ccatgatgcc 2880 cagctaattt ttgtattttt agtggagatg gggtttcacc ttgttggtca aagctggttt 2940 cgaactcttg acctgaggac atctgcctgc ctcggcctac aaaagtgctg ggattacaga 3000 tgtgagccac catgcatggc ctgttttttg actttttaat agccattctg actggtgtgg 3060 gatggcgtgt tattgtggtt ttgatttgca tttttcttac gatgtgtaat gagcattttt 3120 tcatgtttgt tggctgcttg tatgtcttct tttgagaagt gtctgttcat gtcctttgtc 3180 catttttaaa tggggttatc tgtcttttgc tggttgattt gcttaaattc cttacagatt 3240 ctattagtcc ttcgttgggt gcagtctgtg aatatttttt cccagtccat aggttgtctg 3300 tttactctgt tgatagtttc ttttgctgtg cagaagttct ttagtttaat taggacctac 3360 ttgtcgtttt tatttttgtt gcaattgctt ttggagactt agccaaaaat tcttcgccaa 3420 gaccaattca agaagggtat atcataagtt tttcacaatt tggagtctta cacttaaatc 3480 ctcaatgtga ttaacattta aatcagtaga cttggaataa atgattttac acaccgcaat 3540 gtagatggcc tcacctaatc agttgaaggc cttaagagaa aagactaggc aactcccttt 3600 gggtcccctc ccattgtatg ggagctctgt ttttattcta ttaaatcttg caactgcgca 3660 ctcttctggt ctgtgtttgt tacagtttga gctgagcttt tgcttgccat ccaccactgc 3720 tgtttgccgc cgtcccagat ctgccattga cttccacccc tccagatccg gcagtgtgtc 3780 cgctgcactc ctgatccagc gaggcaccca ttgctgctcc tgatcaggct aaaggctcgt 3840 cattgttgct gaacagctaa gtgtccaggg tcatcctaat tgagctgaac actggtcgct 3900 gggttccatg gttctcttcc atgacctatg gcttctaata gagctataac actcactgca 3960 tggcccaagg ttccattcct tggaatctgt gaggccaaga accccaggtc agagaacaaa 4020 aggccatctt gggagcagcc cacccctatc ttgggagtgg cccgccacat cttgggagct 4080 ctaagaacaa agaccatcct ataacatctg gtggcccgta tgggtattct tcaaagtgtc 4140 tccacaaacc ggaggactac ccccagactg cagtaagtgt tgtcatggag actacagctt 4200 tcgaggctac caaggccccc ctgggccacc gggccctcct ggcattccag gaaaccatgg 4260 aaacaatggc aacaatggag ccactggtca tgaaggagcc aaaggtgaga agggcgacaa 4320 aggtgacctg gggcctcgag gggagcgggg gcagcatggc cccaaaggag agaagggcta 4380 cccggggatt ccaccagaac ttcaggctgg agtgcagtgg tgtgatcttg gctcactgca 4440 gcctccacca aggttcaagc gattctcttg cctcagcctc tggagtag ctg gga tta 4497 Leu Gly Leu 1 cag att gca ttc atg gct tct ctg gca acc cac ttc agc aat cag aac 4545 Gln Ile Ala Phe Met Ala Ser Leu Ala Thr His Phe Ser Asn Gln Asn 5 10 15 agt ggg att atc ttc agc agt gtt gag acc aac att gga aac ttc ttt 4593 Ser Gly Ile Ile Phe Ser Ser Val Glu Thr Asn Ile Gly Asn Phe Phe 20 25 30 35 gat gtc atg act ggt aga ttt ggg gcc cca gta tca ggt gtg tat ttc 4641 Asp Val Met Thr Gly Arg Phe Gly Ala Pro Val Ser Gly Val Tyr Phe 40 45 50 ttc acc ttc agc atg atg aag cat gag gat gtt gag gaa gtg tat gtg 4689 Phe Thr Phe Ser Met Met Lys His Glu Asp Val Glu Glu Val Tyr Val 55 60 65 tac ctt atg cac aat ggc aac aca gtc ttc agc atg tac agc tat gaa 4737 Tyr Leu Met His Asn Gly Asn Thr Val Phe Ser Met Tyr Ser Tyr Glu 70 75 80 atg aag ggc aaa tca gat aca tcc agc aat cat gct gtg ctg aag cta 4785 Met Lys Gly Lys Ser Asp Thr Ser Ser Asn His Ala Val Leu Lys Leu 85 90 95 gcc aaa ggg gat gag gtt tgg ctg cga atg ggc aat ggc gct ctc cat 4833 Ala Lys Gly Asp Glu Val Trp Leu Arg Met Gly Asn Gly Ala Leu His 100 105 110 115 ggg gac cac caa cgc ttc tcc acc ttt gca gga ttc ctg ctc ttt gaa 4881 Gly Asp His Gln Arg Phe Ser Thr Phe Ala Gly Phe Leu Leu Phe Glu 120 125 130 act aag taaatatatg actagaatag ctccactttg gggaagactt gtagctgagc 4937 Thr Lys tgatttgtta cgatctgagg aacattaaag ttgagggttt tacattgctg tattcaaaaa 4997 attattggtt gcaatgttgt tcacgctaca ggtacaccaa taatgttgga caattcaggg 5057 gctcagaaga atcaaccaca aaatagtctt ctcagatgac cttgactaat atactcagca 5117 tctttatcac tctttccttg gcacctaaaa gataattctc ctctgacgca ggttggaaat 5177 atttttttct atcacagaag tcatttgcaa agaattttga ctactctgct tttaatttaa 5237 taccagtttt caggaacccc tgaagtttta agttcattat tctttataac atttgagaga 5297 atcggatgta gtgatatgac agggctgggg caagaacagg ggcactagct gccttattag 5357 ctaatttagt gccctccgtg ttcagcttag cctttgaccc tttccttttg atccacaaaa 5417 tacattaaaa ctctgaattc acatacaatg ctattttaaa gtcaatagat tttagctata 5477 aagtgcttga ccagtaatgt ggttgtaatt ttgtgtatgt tcccccacat cgcccccaac 5537 ttcggatgtg gggtcaggag gttgaggttc actattaaca aatgtcataa atatctcata 5597 gaggtacagt gccaatagat attcaaatgt tgcatgttga ccagagggat tttatatctg 5657 aagaacatac actattaata aataccttag agaaagattt tgacctggct ttagataaaa 5717 ctgtggcaag aaaaatgtaa tgagcaatat atggaaataa acacaccttt gttaaagat 5776 <210> 16 <211> 1796 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(733) <400> 16 c agc ctg cgg tct gag tgc tgc gcc acc ctc ggg gca gcc tgg ggg agc 49 Ser Leu Arg Ser Glu Cys Cys Ala Thr Leu Gly Ala Ala Trp Gly Ser 1 5 10 15 ccc tgc gaa cgc tgc gag atc gac cct gcc tgt gcc cgg ggc ttt gcc 97 Pro Cys Glu Arg Cys Glu Ile Asp Pro Ala Cys Ala Arg Gly Phe Ala 20 25 30 cgg atg acg ggt gtc acc tgc aat gat gtg aac gag tgt gag tcc ttc 145 Arg Met Thr Gly Val Thr Cys Asn Asp Val Asn Glu Cys Glu Ser Phe 35 40 45 ccg gga gtc tgt ccc aac ggg cgt tgc gtc aac act gct ggg tct ttc 193 Pro Gly Val Cys Pro Asn Gly Arg Cys Val Asn Thr Ala Gly Ser Phe 50 55 60 cgc tgt gag tgt cca gag ggc ctg atg ctg gac gcc tca ggc cgg ctg 241 Arg Cys Glu Cys Pro Glu Gly Leu Met Leu Asp Ala Ser Gly Arg Leu 65 70 75 80 tgc gtg gat gtg aga ttg gaa cca tgt ttc ctg cga tgg gat gag gat 289 Cys Val Asp Val Arg Leu Glu Pro Cys Phe Leu Arg Trp Asp Glu Asp 85 90 95 gag tgt ggg gtc acc ctg cct ggc aag tac cgg atg gac gtc tgc tgc 337 Glu Cys Gly Val Thr Leu Pro Gly Lys Tyr Arg Met Asp Val Cys Cys 100 105 110 tgc tcc atc ggg gcc gtg tgg gga gtc gag tgc gag gcc tgc ccg gat 385 Cys Ser Ile Gly Ala Val Trp Gly Val Glu Cys Glu Ala Cys Pro Asp 115 120 125 ccc gag tct ctg gag ttc gcc agc ctg tgc ccg cgg ggg ctg ggc ttc 433 Pro Glu Ser Leu Glu Phe Ala Ser Leu Cys Pro Arg Gly Leu Gly Phe 130 135 140 gcc agc cgg gac ttc ctg tct ggc cga cca ttc tat aaa gat gtg aat 481 Ala Ser Arg Asp Phe Leu Ser Gly Arg Pro Phe Tyr Lys Asp Val Asn 145 150 155 160 gaa tgc aag gtg ttc cct ggc ctc tgc acg cac ggt acc tgc aga aac 529 Glu Cys Lys Val Phe Pro Gly Leu Cys Thr His Gly Thr Cys Arg Asn 165 170 175 acg gtg ggc agc ttc cac tgc gcc tgt gcg ggg ggc ttc gcc ctg gat 577 Thr Val Gly Ser Phe His Cys Ala Cys Ala Gly Gly Phe Ala Leu Asp 180 185 190 gcc cag gaa cgg aac tgc aca gat atc gac gag tgt cgc atc tct cct 625 Ala Gln Glu Arg Asn Cys Thr Asp Ile Asp Glu Cys Arg Ile Ser Pro 195 200 205 gac ctc tgc ggc cag ggc acc tgt gtc aac acg ccg ggc agc ttt gag 673 Asp Leu Cys Gly Gln Gly Thr Cys Val Asn Thr Pro Gly Ser Phe Glu 210 215 220 tgc gag tgt ttt ccc ggc tac gag agt ggc ttc atg ctg atg aag aac 721 Cys Glu Cys Phe Pro Gly Tyr Glu Ser Gly Phe Met Leu Met Lys Asn 225 230 235 240 tgc atg ggt cgg tgactgccgg gcaggggtgt ggtgggcgcc ctgggcaggg 773 Cys Met Gly Arg agggcattga ggagagggag ggtggggacg gctgttgctg cgtggacgtg gatggagggg 833 gcaggaggag ggaggagctg taaattagct gaggtacagt gagtctgggc tccatgaggc 893 ctcgtcctta ggagagagac ctggggcctg agacctgggg gtggccggca cactggggtg 953 tggtctccca gggagggtgt gtagcttggg tagaggacag ggaccctcag agaagcctgg 1013 gaaatactgc cggttatgag gcctctcgtc cccatcattg acttcgttat tcatttgatg 1073 agcatttcac atgcatcctc tgagctagag gcactgcagg gagctctagc tccagggagc 1133 cctctttcct tggagctcac agcctaacag gaagacagac atgaataaca tgaatcgctg 1193 aggaaatgca aaactgggct gggtgcagtg gccctcgcct gtaatcccag cattttgaga 1253 ggctgaggca gtaggattgc ttgagtccag gagttcgagg ccagcctggg caacataaca 1313 agaccctgtc actacaaagt tttttaaaaa ttagctaggc atggtggcgc gtgctactcg 1373 ggaggctgag gagggaggat cccttgagcc caggaggttg aggctgcagt gaaccataat 1433 cgcacttttg cactccagcc tgggtgacag agtgagaccc tgtctaaaga aaaaaggaag 1493 gaaggaagag gaaaaagcca ggcatggtgg ctcatgcctg taatcccagc actttgggag 1553 gctgaggtgg gcagattgcc tgagttcagg agtttgaaac cagcctgggc aacatggtga 1613 aaccccgtct ctattaaaat acaaaaaatt agctgggtgt ggtggcgtgc acctgtaggt 1673 ccagctactc aggaggctga ggcaggagaa ttgcttgaac ccaggaggtg gaggttgcag 1733 tgagccgaga tcgcgccact gcactccagc ctgggcgaca gagcgagatt ctgtctccaa 1793 att 1796 <210> 17 <211> 5751 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3467)..(4897) <400> 17 gagggcataa ttttttctca attcatattt gcaaattgtt tattgagagt cagtgttgta 60 tagagggata aacatagatt tggagataca gtcacttgcc aagttgcacc gcagattcct 120 ctggtataaa atgaaaataa tgtgactcta caggattgaa taataattaa ctgaagtagt 180 atatatagta cccatcacag aataggtttg taacaaatgt taggtttgta aaaatgtttt 240 gtcctgtcat aattttaaaa taggtaaatt ggacattttc tgtttttctt tataacataa 300 atccgatatt cacatgcagt ttttttccaa cttttatttt aagttcatgg gtgcatgtgc 360 agatgtgaag gttcgttata taagtaaatg tgtgccatgg tggttttgct gcacagatca 420 tcccatcacc taggtattaa gcccagcgtt cattagcaat tcttcctgac agctgcagtt 480 ttgattatgt gcagctctca attggctttt ccccgtttaa gatgttagac cagtggttct 540 cagccttgac taattagaat catgtgagga gcttttagaa ctcccattgc tcaggccaac 600 cctccaatca attaaattac catctctggg acttacacat ttgtgttttg ttttctcttt 660 tttgactccc taagtgattt ttatatggag ccaagattga aaacagtgtt agacacacac 720 tttcccaatt tatgctttga aaacaaagac cttagttcag agacttatga gatagggtta 780 tgattagggg aagagtaggc cccacaagtt tcagggtagt gaagattctg aagggtacaa 840 gcgataaagg agcctgagtt tctgggtgaa ctcagaaaca aggaatccta gaagggctga 900 gagcagaaca gaacctcgga atagtctctg aaataaaaga gtggagagta taagaaacag 960 aatggaggca ggccccagga ggattcaatc aggaattctg accttggggc cataaatagg 1020 tttcatatct tcacagaaag ggtttacaca acttttgtat atcattttct gagatgtctg 1080 aatcctagaa aaagataaag aacatcagta tgtgaaaaag ccaagggcta aggtaatggt 1140 aatcagacta cagttctaga aatgcctctg gatctttaat acatgactgg cagctcttct 1200 aaacctctat gttacctcta ttagaatatt atttctgatg tagtttgtgg agaaacaaag 1260 caggaatgga ggagaacact gtatacagta tactttataa gcactaaata aatatgtaaa 1320 aactctgaaa tataatctga gtttatagtc ataatgaaga ttattagctc aataatctag 1380 ggtagaggtg tccaatcttt cggcttccat gggccacgtt ggaagaagaa ttaccttggg 1440 ccacacataa aatacactaa cactaacaat aactgatgag ttaaaaaaaa tcacataaaa 1500 atctcataat gttttaagaa catttgtgaa tttgtgttga gtcacattca aagacacctt 1560 gggccacatg tggcctgtgg gctgcaagtt ggacaagctt gatctagggc aagtgctcaa 1620 cagtggctgc acagttaaat cgtgtgtaaa gctttcaaaa agtaagggtg cctaattcca 1680 ctcctagaga ttctgattta attggtctga catggagttg taacatcaat atttttgaat 1740 ttttccatat gattctaatg tgtaaccagc attgagaacc actaatccag aggaaaccag 1800 gactcctgct tatcttgcac aacttgggta ccctcaaaat atatggtatt ggcaaagtta 1860 atctgagcct aagttccagc acctgtaaaa gatggtacga atttcctaaa agaggttgtt 1920 gtgaatatgt actctcctgg gtttagtcct tagctttgca agaagtccaa aatcttcaag 1980 atgatcagcc tcaaatcagg gactcactaa ccgcaaacaa acttgaaagt ggctgataac 2040 taactggaaa gatattactt taatatgttt ctcacaaagc ctgtgataat catttgccat 2100 atttgtgatc atagaaattt cttgtccctg ccctagaaac attgaatcat gttctccagg 2160 ggagagcctg ggaatctata tttttaactg acaccccagt tgatttttat caaagaagtc 2220 tgggaaacat tgtactttaa gttattgtat tgtcattctg gtattgattt atggtaagag 2280 gagatacata tttccatttc ctagtttttc ttgatgtctg tcatccaggg tatccttttc 2340 ttggtatcaa agaatatgaa aaaccaatta taatcagaaa gtgacttagt atgcatgaaa 2400 ttagagcata gaaaaggata gttttgaggg aacatttcat tcatattttg acataacctg 2460 ctgagttttc ctgggcccgc aatagccagt agtgtgcagc ctcattttct tcagagtcag 2520 catctttctt tccccttgca agcagtctcc tgtttctatg aatagtcttt gctcagacaa 2580 ggccaatata cttggtaata attaatttag cttctttgaa atgattaggt cactttttgg 2640 tttaaaagat taccatggtt gtccccaaaa tctttgcatg taccaattta tttcctcctc 2700 cctagggtca gaatgatttt atatttggct tatgaaatgt attaatttgc ttcttctggt 2760 caaagataag tggaaggatg atgagatttt taaaaaatta atgtatccct tgcttctaat 2820 tctacctaca aagtggaata gtgtgctagt tactatatag ttcccagtgt atagcttttg 2880 actcttttga agtggtaact agtagttttg ttttagaatt ttgctttcag cttttatcct 2940 gagagtgggg ctcactgaac ctctctcctt tctaaaatct gtggaaatta cttttggtaa 3000 ctaaggcact gcagtgatct caggtaagag agtaaaaaat ttgcctttat ttgtttttaa 3060 tgttttggga cgtttcaggt tttggttggg tggaaacaga gttggggcaa acaaaaagag 3120 gctggttaag agattcagag gcaaaggttg gttggccatg ctaaatttca ggtgcctgtt 3180 gcacctccat gtagcaacag taagtagaca gatagcagat tcttagggaa gaagttaagc 3240 tagagaagca gtgtggtgtg gtgtaaagaa ttctgggcat tcaattaaga ggtgtgggct 3300 ctgagaggct aacactacta ctaacttgct ctgtgacttt gaccaagtca tttgacctct 3360 ctgggcccca tctttattgg aaaatgtcaa gtagatggtc tctaataaat ttttgtccag 3420 ttctaacatt atgtgattct aaatgtattt atactgacct tcttaa ctt gaa ctc 3475 Leu Glu Leu 1 ttt gtt ttt tca gca ttt agt atg aga acc tat gtt tgc cat att tgt 3523 Phe Val Phe Ser Ala Phe Ser Met Arg Thr Tyr Val Cys His Ile Cys 5 10 15 agt att gct ttt aca tct tta gat atg ttc cgg tcc cac atg caa gga 3571 Ser Ile Ala Phe Thr Ser Leu Asp Met Phe Arg Ser His Met Gln Gly 20 25 30 35 agt gaa cat caa att aaa gaa tcc att gtt atc aat cta gtg aag aat 3619 Ser Glu His Gln Ile Lys Glu Ser Ile Val Ile Asn Leu Val Lys Asn 40 45 50 tca agg aag aca caa gac tct tac caa aat gag tgt gca gat tac atc 3667 Ser Arg Lys Thr Gln Asp Ser Tyr Gln Asn Glu Cys Ala Asp Tyr Ile 55 60 65 aat gtg cag aaa gcc aga gga cta gag gcc aag act tgt ttc aga aag 3715 Asn Val Gln Lys Ala Arg Gly Leu Glu Ala Lys Thr Cys Phe Arg Lys 70 75 80 atg gaa gag agt tct ttg gaa acc cgt aga tac aga gaa gtg gtc gat 3763 Met Glu Glu Ser Ser Leu Glu Thr Arg Arg Tyr Arg Glu Val Val Asp 85 90 95 tcc aga ccc aga cat aga atg ttt gaa caa aga ctc cca ttt gag act 3811 Ser Arg Pro Arg His Arg Met Phe Glu Gln Arg Leu Pro Phe Glu Thr 100 105 110 115 ttc cgg aca tac gca gca cca tac aat att tca caa gca atg gaa aag 3859 Phe Arg Thr Tyr Ala Ala Pro Tyr Asn Ile Ser Gln Ala Met Glu Lys 120 125 130 cag tta cct cat tca aag aag aca tat gac tct ttc caa gat gaa ctt 3907 Gln Leu Pro His Ser Lys Lys Thr Tyr Asp Ser Phe Gln Asp Glu Leu 135 140 145 gaa gat tac atc aaa gta cag aaa gcc aga gga cta gat cca aag act 3955 Glu Asp Tyr Ile Lys Val Gln Lys Ala Arg Gly Leu Asp Pro Lys Thr 150 155 160 tgt ttc aga aag atg aga gag aac tct gtg gat act cat ggg tac aga 4003 Cys Phe Arg Lys Met Arg Glu Asn Ser Val Asp Thr His Gly Tyr Arg 165 170 175 gaa atg gtt gat tct gga ccc aga tca aga atg tgt gag caa aga ttt 4051 Glu Met Val Asp Ser Gly Pro Arg Ser Arg Met Cys Glu Gln Arg Phe 180 185 190 195 tca cat gag gct tcc cag acc tac caa cga cca tac cat att tca cca 4099 Ser His Glu Ala Ser Gln Thr Tyr Gln Arg Pro Tyr His Ile Ser Pro 200 205 210 gtg gaa agc cag tta cct cag tgg cta cca acc cat tca aag agg aca 4147 Val Glu Ser Gln Leu Pro Gln Trp Leu Pro Thr His Ser Lys Arg Thr 215 220 225 tat gat tct ttc caa gat gaa ctt gaa gat tac ata aaa gtg cag aaa 4195 Tyr Asp Ser Phe Gln Asp Glu Leu Glu Asp Tyr Ile Lys Val Gln Lys 230 235 240 gcc aga gga cta gag cca aaa act tgt ttc aga aag ata gga gat agc 4243 Ala Arg Gly Leu Glu Pro Lys Thr Cys Phe Arg Lys Ile Gly Asp Ser 245 250 255 tct gta gaa aca cac agg aac aga gaa atg gtt gat gtc aga ccc aga 4291 Ser Val Glu Thr His Arg Asn Arg Glu Met Val Asp Val Arg Pro Arg 260 265 270 275 cat aga atg ttg gag caa aag ctc cca tgt gag act ttc cag acc tat 4339 His Arg Met Leu Glu Gln Lys Leu Pro Cys Glu Thr Phe Gln Thr Tyr 280 285 290 tca gga cca tat agt att tca caa gta gtg gaa aac cag tta cct cat 4387 Ser Gly Pro Tyr Ser Ile Ser Gln Val Val Glu Asn Gln Leu Pro His 295 300 305 tgc tta cca gct cat gat agc aaa cag aga cta gat tct att agc tac 4435 Cys Leu Pro Ala His Asp Ser Lys Gln Arg Leu Asp Ser Ile Ser Tyr 310 315 320 tgt caa ctc acc aga gac tgt ttc cca gaa aaa cca gta ccc ttg agc 4483 Cys Gln Leu Thr Arg Asp Cys Phe Pro Glu Lys Pro Val Pro Leu Ser 325 330 335 ctt aat cag caa gaa aat aac tct ggc tca tac agt gta gaa tct gaa 4531 Leu Asn Gln Gln Glu Asn Asn Ser Gly Ser Tyr Ser Val Glu Ser Glu 340 345 350 355 gtt tac aag cac ctc tct tca gaa aac aat act gct gac cat caa gca 4579 Val Tyr Lys His Leu Ser Ser Glu Asn Asn Thr Ala Asp His Gln Ala 360 365 370 ggt cat aaa cgg aaa cat cag aag aga aaa cga cac cta gaa gaa ggc 4627 Gly His Lys Arg Lys His Gln Lys Arg Lys Arg His Leu Glu Glu Gly 375 380 385 aaa gaa agg cca gag aaa gag cag tcc aag cat aaa agg aaa aag agt 4675 Lys Glu Arg Pro Glu Lys Glu Gln Ser Lys His Lys Arg Lys Lys Ser 390 395 400 tat gaa gat aca gat tta gac aaa gac aag agc atc aga caa agg aaa 4723 Tyr Glu Asp Thr Asp Leu Asp Lys Asp Lys Ser Ile Arg Gln Arg Lys 405 410 415 aga gag gag gat aga gtc aag gtc agt tca gga aag ctt aag cat cga 4771 Arg Glu Glu Asp Arg Val Lys Val Ser Ser Gly Lys Leu Lys His Arg 420 425 430 435 aaa aag aaa aaa agc cat gat gta ccc tcc gag aaa gaa gaa cgt aag 4819 Lys Lys Lys Lys Ser His Asp Val Pro Ser Glu Lys Glu Glu Arg Lys 440 445 450 cac agg aaa gag aaa aag aaa tct gtt gaa gaa agg aca gaa gag gaa 4867 His Arg Lys Glu Lys Lys Lys Ser Val Glu Glu Arg Thr Glu Glu Glu 455 460 465 atg ctt tgg gat gag tct att ctt gga ttt tgaatgttta gttttgttta 4917 Met Leu Trp Asp Glu Ser Ile Leu Gly Phe 470 475 cccaaggttg aattgaaaaa aaaaaacagt caatatggat ttagaaaaag gaacacctga 4977 tgaagaaaag gagaggtaga tacagtcagt gtcacttcag gacacttagg ttttttttgt 5037 ataaaaattt aaattgaatt aaaagaagga aaaaaaaagc ccaaacttaa cctctgagaa 5097 agaacataag aactcaagga gaacataaga gaaaaggaaa cctgttacag aaaagacaag 5157 aatctgtgtt ttggaatgag tctattcttg ggtattgaac ttttagtttt gtttgcccaa 5217 ggattaattg aggaaatcag ctaagaaaat ggactttaga caaaagcaag aggatcagat 5277 gaagaaaagg agaggtagat acagtcagtg tcacttcagg aaagctattt aaaaaaactt 5337 gaaatttaat tgaaagaaga aacaacaaca aaaaagccta aacctagcct ctgaacaaca 5397 ctaacatgag aacacaagaa cttaagagaa aaagaaacct actcaagaaa agacagaaga 5457 gacagtgatt tgggatgagt ctactctagg attttcaact ttttagtttt gttccttcaa 5517 agttgaagga aaaaaagttt ggttttataa aattcatgtt attgtaattt ttctaggtgg 5577 atggctattt taatctctaa aaaagccaag tgaagtaaaa gtattcagta tgccttttcc 5637 tcaagttact ttccttcatt ttcttaaaaa agaaaaaaaa ttattaaatg tttctcacat 5697 atctcacata taatgtaatt tccctaaatg aagttgtctc tacttctgct catc 5751 <210> 18 <211> 5370 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(4109) <400> 18 cc ccg cgc cag ggc aag tcc acc ctc ctg gag atc tta cag acg ggg 47 Pro Arg Gln Gly Lys Ser Thr Leu Leu Glu Ile Leu Gln Thr Gly 1 5 10 15 agg gcc ccc cag gtg gtg cat gga gag gcc acc atc agg acc acc aag 95 Arg Ala Pro Gln Val Val His Gly Glu Ala Thr Ile Arg Thr Thr Lys 20 25 30 tgg gag ctc cag agg ccg gct ggc tca aga gcc aag gtt gag tcc gtg 143 Trp Glu Leu Gln Arg Pro Ala Gly Ser Arg Ala Lys Val Glu Ser Val 35 40 45 gag ttc aac gtc tgg gac atc ggg gga ccg gcc agc atg gcc act gtc 191 Glu Phe Asn Val Trp Asp Ile Gly Gly Pro Ala Ser Met Ala Thr Val 50 55 60 aac cag tgc ttc ttc acg gac aag gcc ctg tac gtg gtg gtc tgg aac 239 Asn Gln Cys Phe Phe Thr Asp Lys Ala Leu Tyr Val Val Val Trp Asn 65 70 75 ctg gcg ctg ggg gag gag gcc gtg gcc aac ctc cag ttc tgg ctg ctc 287 Leu Ala Leu Gly Glu Glu Ala Val Ala Asn Leu Gln Phe Trp Leu Leu 80 85 90 95 aac atc gag gcc aag gcc cca aac gcc gtg gtg ctg gtg gtc ggg acg 335 Asn Ile Glu Ala Lys Ala Pro Asn Ala Val Val Leu Val Val Gly Thr 100 105 110 cac ctg gat tta att gaa gcc aag ttc cgt gtg gaa agg att gca acg 383 His Leu Asp Leu Ile Glu Ala Lys Phe Arg Val Glu Arg Ile Ala Thr 115 120 125 ctg cgt gcc tat gtg ctg gca ctc tgc cgc tcc ccc tcc ggc tcc agg 431 Leu Arg Ala Tyr Val Leu Ala Leu Cys Arg Ser Pro Ser Gly Ser Arg 130 135 140 gcc aca ggc ttc cca gac atc acc ttc aaa cac tta cat gag att tcc 479 Ala Thr Gly Phe Pro Asp Ile Thr Phe Lys His Leu His Glu Ile Ser 145 150 155 tgc aag agc ctg gaa ggt cag gaa ggg ctg cga cag ctg att ttc cac 527 Cys Lys Ser Leu Glu Gly Gln Glu Gly Leu Arg Gln Leu Ile Phe His 160 165 170 175 gtc acg tgc agc atg aag gac gtg ggc agc acc atc ggc tgc cag cga 575 Val Thr Cys Ser Met Lys Asp Val Gly Ser Thr Ile Gly Cys Gln Arg 180 185 190 ctg gca ggg cgg ctg atc ccc agg agc tac ctg agc ctg cag gag gcc 623 Leu Ala Gly Arg Leu Ile Pro Arg Ser Tyr Leu Ser Leu Gln Glu Ala 195 200 205 gtg ctg gca gag cag cag cgc cgc agc cgg gac gac gac gtg cag tac 671 Val Leu Ala Glu Gln Gln Arg Arg Ser Arg Asp Asp Asp Val Gln Tyr 210 215 220 ctg acg gac agg cag ctg gag cag ctg gtg gag cag acg ccc gac aac 719 Leu Thr Asp Arg Gln Leu Glu Gln Leu Val Glu Gln Thr Pro Asp Asn 225 230 235 gac atc aag gac tac gag gac ctg cag tca gcc atc agc ttc ctc ata 767 Asp Ile Lys Asp Tyr Glu Asp Leu Gln Ser Ala Ile Ser Phe Leu Ile 240 245 250 255 gaa acc ggc acc ctg ctc cat ttc ccg gac acc agc cac ggc ctg agg 815 Glu Thr Gly Thr Leu Leu His Phe Pro Asp Thr Ser His Gly Leu Arg 260 265 270 aac ctc tac ttc ctc gac cct att tgg ctc tcc gaa tgt ctg cag agg 863 Asn Leu Tyr Phe Leu Asp Pro Ile Trp Leu Ser Glu Cys Leu Gln Arg 275 280 285 atc ttt aat att aag ggc tct cgg tca gtg gcc aag aat ggg gtg atc 911 Ile Phe Asn Ile Lys Gly Ser Arg Ser Val Ala Lys Asn Gly Val Ile 290 295 300 aga gca gaa gac ctc agg atg ctg ctg gtg ggg act ggc ttc acg cag 959 Arg Ala Glu Asp Leu Arg Met Leu Leu Val Gly Thr Gly Phe Thr Gln 305 310 315 cag acg gaa gag cag tac ttc cag ttc ctg gcc aag ttt gag atc gcc 1007 Gln Thr Glu Glu Gln Tyr Phe Gln Phe Leu Ala Lys Phe Glu Ile Ala 320 325 330 335 ctg ccc gtc gcc aat gac agc tac ctc ctg ccc cat ctc ctt cca tct 1055 Leu Pro Val Ala Asn Asp Ser Tyr Leu Leu Pro His Leu Leu Pro Ser 340 345 350 aaa cct ggc ctg gac acc cac ggt atg cgg cac ccc aca gcc aac acc 1103 Lys Pro Gly Leu Asp Thr His Gly Met Arg His Pro Thr Ala Asn Thr 355 360 365 att cag agg gta ttt aag atg agc ttc gtt ccc gtt ggc ttc tgg caa 1151 Ile Gln Arg Val Phe Lys Met Ser Phe Val Pro Val Gly Phe Trp Gln 370 375 380 agg ttt ata gca cgg atg ctg atc agc ctg gcg gag atg gac ctg cag 1199 Arg Phe Ile Ala Arg Met Leu Ile Ser Leu Ala Glu Met Asp Leu Gln 385 390 395 ctt ttt gaa aac aag aag aat act aaa agc agg aac agg aaa gtc acc 1247 Leu Phe Glu Asn Lys Lys Asn Thr Lys Ser Arg Asn Arg Lys Val Thr 400 405 410 415 att tac agt ttt aca gga aac cag aga aat cgc tgt agc aca ttc aga 1295 Ile Tyr Ser Phe Thr Gly Asn Gln Arg Asn Arg Cys Ser Thr Phe Arg 420 425 430 gtg aaa aga aat cag acc atc tat tgg cag gaa ggg ctc ctg gtc act 1343 Val Lys Arg Asn Gln Thr Ile Tyr Trp Gln Glu Gly Leu Leu Val Thr 435 440 445 ttt gat ggg ggc tac ctc agt gtg gaa tct tcc gac gtg aac tgg aaa 1391 Phe Asp Gly Gly Tyr Leu Ser Val Glu Ser Ser Asp Val Asn Trp Lys 450 455 460 aag aag aaa agc gga gga atg aaa att gtt tgc caa tca gaa gtg agg 1439 Lys Lys Lys Ser Gly Gly Met Lys Ile Val Cys Gln Ser Glu Val Arg 465 470 475 gac ttc tca gcc atg gct ttc atc acg gac cac gtc aat tcc ttg att 1487 Asp Phe Ser Ala Met Ala Phe Ile Thr Asp His Val Asn Ser Leu Ile 480 485 490 495 gat cag tgg ttt ccc gcc ctg acg gcc aca gag agc gac ggg acg cca 1535 Asp Gln Trp Phe Pro Ala Leu Thr Ala Thr Glu Ser Asp Gly Thr Pro 500 505 510 ctc atg gag cag tac gtg ccc tgc ccg gtc tgc gag aca gcc tgg gcc 1583 Leu Met Glu Gln Tyr Val Pro Cys Pro Val Cys Glu Thr Ala Trp Ala 515 520 525 cag cac acg gac ccc agt gag aaa tca gag gat gtg cag tac ttc gac 1631 Gln His Thr Asp Pro Ser Glu Lys Ser Glu Asp Val Gln Tyr Phe Asp 530 535 540 atg gaa gac tgt gtc ctg acg gcc atc gag cgg gac ttc atc tcc tgc 1679 Met Glu Asp Cys Val Leu Thr Ala Ile Glu Arg Asp Phe Ile Ser Cys 545 550 555 ccc aga cac ccg gac ctc ccc gtg ccg ctg cag gag ctg gtc cct gaa 1727 Pro Arg His Pro Asp Leu Pro Val Pro Leu Gln Glu Leu Val Pro Glu 560 565 570 575 ctg ttc atg acc gac ttc ccg gcc agg ctc ttc ctg gag aac agc aag 1775 Leu Phe Met Thr Asp Phe Pro Ala Arg Leu Phe Leu Glu Asn Ser Lys 580 585 590 ctg gag cac agc gag gac gag ggc agc gtc ctg ggc cag ggc ggc agt 1823 Leu Glu His Ser Glu Asp Glu Gly Ser Val Leu Gly Gln Gly Gly Ser 595 600 605 ggc acc gtc atc tac cgg gcc cgg tac cag ggc cag cct gtg gcc gtc 1871 Gly Thr Val Ile Tyr Arg Ala Arg Tyr Gln Gly Gln Pro Val Ala Val 610 615 620 aag cgc ttc cac atc aaa aaa ttc aag aac ttt gct aac gta ccg gca 1919 Lys Arg Phe His Ile Lys Lys Phe Lys Asn Phe Ala Asn Val Pro Ala 625 630 635 gac acc atg ctg agg cac ctg cgg gcc acc gat gcc atg aag aac ttc 1967 Asp Thr Met Leu Arg His Leu Arg Ala Thr Asp Ala Met Lys Asn Phe 640 645 650 655 tcc gag ttc cgg cag gag gcc agc atg ctg cac gcg ctg cag cac ccc 2015 Ser Glu Phe Arg Gln Glu Ala Ser Met Leu His Ala Leu Gln His Pro 660 665 670 tgc atc gtg gcg ctc atc ggc atc agc atc cac ccg ctc tgc ttc gcc 2063 Cys Ile Val Ala Leu Ile Gly Ile Ser Ile His Pro Leu Cys Phe Ala 675 680 685 ctg gag ctc gcg ccg ctc agc agc ctc aac acc gtg ctg tcc gag aac 2111 Leu Glu Leu Ala Pro Leu Ser Ser Leu Asn Thr Val Leu Ser Glu Asn 690 695 700 gcc aga gat tct tcc ttt ata ccc ctg gga cac atg ctc acc caa aaa 2159 Ala Arg Asp Ser Ser Phe Ile Pro Leu Gly His Met Leu Thr Gln Lys 705 710 715 ata gcc tac cag atc gcc tcg ggc ctg gcc tac ctg cac aag aaa aac 2207 Ile Ala Tyr Gln Ile Ala Ser Gly Leu Ala Tyr Leu His Lys Lys Asn 720 725 730 735 atc atc ttc tgt gac ctg aag tcg gac aac att ctg gtg tgg tcc ctt 2255 Ile Ile Phe Cys Asp Leu Lys Ser Asp Asn Ile Leu Val Trp Ser Leu 740 745 750 gac gtc aag gag cac atc aac atc aag cta tct gac tac ggg att tcg 2303 Asp Val Lys Glu His Ile Asn Ile Lys Leu Ser Asp Tyr Gly Ile Ser 755 760 765 agg cag tca ttc cat gag ggc gcc cta ggc gtg gag ggc act cct ggc 2351 Arg Gln Ser Phe His Glu Gly Ala Leu Gly Val Glu Gly Thr Pro Gly 770 775 780 tac cag gcc cca gag atc agg cct cgc att gta tat gat gag aag gta 2399 Tyr Gln Ala Pro Glu Ile Arg Pro Arg Ile Val Tyr Asp Glu Lys Val 785 790 795 gat atg ttc tcc tat gga atg gtg ctc tac gag ttg ctg tca gga cag 2447 Asp Met Phe Ser Tyr Gly Met Val Leu Tyr Glu Leu Leu Ser Gly Gln 800 805 810 815 cgc cct gca ctg ggc cac cac cag ctc cag att gcc aag aag ctg tcc 2495 Arg Pro Ala Leu Gly His His Gln Leu Gln Ile Ala Lys Lys Leu Ser 820 825 830 aag ggc atc cgc ccg gtt ctg ggg cag ccg gag gaa gtg cag ttc cgg 2543 Lys Gly Ile Arg Pro Val Leu Gly Gln Pro Glu Glu Val Gln Phe Arg 835 840 845 cga ctg cag gcg ctc atg atg gag tgc tgg gac act aag cca gag aag 2591 Arg Leu Gln Ala Leu Met Met Glu Cys Trp Asp Thr Lys Pro Glu Lys 850 855 860 cga ccg ctg gcc ctg tcg gtg gtg agc cag atg aag gac ccg act ttt 2639 Arg Pro Leu Ala Leu Ser Val Val Ser Gln Met Lys Asp Pro Thr Phe 865 870 875 gcc acc ttc atg tat gaa ctg tgc tgt ggg aag cag aca gcc ttc ttc 2687 Ala Thr Phe Met Tyr Glu Leu Cys Cys Gly Lys Gln Thr Ala Phe Phe 880 885 890 895 tca tcc cag ggc cag gag tac acc gtg gtg ttt tgg gat gga aaa gag 2735 Ser Ser Gln Gly Gln Glu Tyr Thr Val Val Phe Trp Asp Gly Lys Glu 900 905 910 gag tcc agg aac tac acg gtg gtg aac aca gag aag ggc ctc atg gag 2783 Glu Ser Arg Asn Tyr Thr Val Val Asn Thr Glu Lys Gly Leu Met Glu 915 920 925 gtg cag agg atg tgc tgc cct ggg atg aag gtg agc tgc cag ctc cag 2831 Val Gln Arg Met Cys Cys Pro Gly Met Lys Val Ser Cys Gln Leu Gln 930 935 940 gtc cag aga tcc ctg tgg aca gcc acc gag gac cag aaa atc tac atc 2879 Val Gln Arg Ser Leu Trp Thr Ala Thr Glu Asp Gln Lys Ile Tyr Ile 945 950 955 tac acc ctc aag ggc atg tgc ccc tta aac aca ccc caa cag gcc ttg 2927 Tyr Thr Leu Lys Gly Met Cys Pro Leu Asn Thr Pro Gln Gln Ala Leu 960 965 970 975 gat act cca gct gtc gtc acc tgc ttc ttg gcc gtg cct gtt att aaa 2975 Asp Thr Pro Ala Val Val Thr Cys Phe Leu Ala Val Pro Val Ile Lys 980 985 990 aag aat tcc tac ctg gtc tta gcg ggc ctc gcc gat ggg ctt gtg gct 3023 Lys Asn Ser Tyr Leu Val Leu Ala Gly Leu Ala Asp Gly Leu Val Ala 995 1000 1005 gtg ttt ccc gtg gtg cgg ggc acc cca aag gac agc tgc tcc tac ctg 3071 Val Phe Pro Val Val Arg Gly Thr Pro Lys Asp Ser Cys Ser Tyr Leu 1010 1015 1020 tgc tca cac aca gcc aac agg tcc aag ttc agc atc gcg gat gaa gac 3119 Cys Ser His Thr Ala Asn Arg Ser Lys Phe Ser Ile Ala Asp Glu Asp 1025 1030 1035 gca cgg cag aac ccc tac cca gtg aag gcc atg gag gtg gtc aac agc 3167 Ala Arg Gln Asn Pro Tyr Pro Val Lys Ala Met Glu Val Val Asn Ser 1040 1045 1050 1055 ggc tct gag gtc tgg tac agc aat ggg ccg ggc ctc ctt gtc atc gac 3215 Gly Ser Glu Val Trp Tyr Ser Asn Gly Pro Gly Leu Leu Val Ile Asp 1060 1065 1070 tgt gcc tcc ctg gag atc tgc agg cgg ctg gag ccc tac atg gcc ccc 3263 Cys Ala Ser Leu Glu Ile Cys Arg Arg Leu Glu Pro Tyr Met Ala Pro 1075 1080 1085 tcc atg gtt acg tca gtc gtg tgc agc tct gag ggc aga ggg gag gag 3311 Ser Met Val Thr Ser Val Val Cys Ser Ser Glu Gly Arg Gly Glu Glu 1090 1095 1100 gtc gtc tgg tgc ctg gat gac aag gcc aac tcc ttg gtg atg tac cac 3359 Val Val Trp Cys Leu Asp Asp Lys Ala Asn Ser Leu Val Met Tyr His 1105 1110 1115 tcc acc acc tac cag ctg tgt gcc cgg tac ttc tgc ggg gtc ccc agc 3407 Ser Thr Thr Tyr Gln Leu Cys Ala Arg Tyr Phe Cys Gly Val Pro Ser 1120 1125 1130 1135 ccc ctc agg gac atg ttt ccc gtg cgg ccc ttg gac acg gaa ccc ccg 3455 Pro Leu Arg Asp Met Phe Pro Val Arg Pro Leu Asp Thr Glu Pro Pro 1140 1145 1150 gca gcc agc cac acg gcc aac cca aag gtg cct gag ggg gac tcc atc 3503 Ala Ala Ser His Thr Ala Asn Pro Lys Val Pro Glu Gly Asp Ser Ile 1155 1160 1165 gcg gac gtg agc atc atg tac agt gag gag ctg ggc acg cag atc ctg 3551 Ala Asp Val Ser Ile Met Tyr Ser Glu Glu Leu Gly Thr Gln Ile Leu 1170 1175 1180 atc cac cag gaa tca ctc act gac tac tgc tcc atg tcc tcc tac tcc 3599 Ile His Gln Glu Ser Leu Thr Asp Tyr Cys Ser Met Ser Ser Tyr Ser 1185 1190 1195 tca tcc cca ccc cgc cag gct gcc agg tcc ccc tca agc ctc ccc agc 3647 Ser Ser Pro Pro Arg Gln Ala Ala Arg Ser Pro Ser Ser Leu Pro Ser 1200 1205 1210 1215 tcc cca gca agt tct tcc agt gtg cct ttc tcc acc gac tgc gag gac 3695 Ser Pro Ala Ser Ser Ser Ser Val Pro Phe Ser Thr Asp Cys Glu Asp 1220 1225 1230 tca gac atg cta cat acg ccc ggt gct gcc tcc gac agg tct gag cat 3743 Ser Asp Met Leu His Thr Pro Gly Ala Ala Ser Asp Arg Ser Glu His 1235 1240 1245 gac ctg acc ccc atg gac ggg gag acc ttc agc cag cac ctg cag gcc 3791 Asp Leu Thr Pro Met Asp Gly Glu Thr Phe Ser Gln His Leu Gln Ala 1250 1255 1260 gtg aag atc ctc gcc gtc aga gac ctc att tgg gtc ccc agg cgc ggt 3839 Val Lys Ile Leu Ala Val Arg Asp Leu Ile Trp Val Pro Arg Arg Gly 1265 1270 1275 gga gat gtt atc gtc att ggc ctg gag aag gat tct gaa gcc cag cgg 3887 Gly Asp Val Ile Val Ile Gly Leu Glu Lys Asp Ser Glu Ala Gln Arg 1280 1285 1290 1295 ggc cga gtc att gcc gtc tta aaa gcc cga gag ctg act ccg cat ggg 3935 Gly Arg Val Ile Ala Val Leu Lys Ala Arg Glu Leu Thr Pro His Gly 1300 1305 1310 gtg ctg gtg gat gct gcc gtg gtg gca aag gac act gtt gtg tgc acc 3983 Val Leu Val Asp Ala Ala Val Val Ala Lys Asp Thr Val Val Cys Thr 1315 1320 1325 ttt gaa aat gaa aac aca gag tgg tgc ctg gcc gtc tgg agg ggc tgg 4031 Phe Glu Asn Glu Asn Thr Glu Trp Cys Leu Ala Val Trp Arg Gly Trp 1330 1335 1340 ggc gcc agg gag ttc gac att ttc tac cag tcc tac gag gag ctg ggc 4079 Gly Ala Arg Glu Phe Asp Ile Phe Tyr Gln Ser Tyr Glu Glu Leu Gly 1345 1350 1355 cgg ctg gag gct tgc act cgc aag aga agg taattcctgt ggaatgactg 4129 Arg Leu Glu Ala Cys Thr Arg Lys Arg Arg 1360 1365 tcacacatca gagctggctg gcccggggct gcagcctgac ccctctgcca tcggcctcta 4189 gttctccaag gacctagaag acagatggag ttctcccctg aactccttgc tgctaagaag 4249 tgctgagaag ttactcgcct ggcggtggct ccagggttct ctggttctct ggagcagagt 4309 tctctgaata ccccatcccc caactgctga ttttacagcc ccagggaaga cagtggtatc 4369 aggctgggag cggcctcctc tggcctcccc catcagtttg caggagcagg ggtgcaggat 4429 cctgttctga gctgggtcaa acaaagcagg gccgggcctt cctgccatcc ccaggtctca 4489 gatggaatta cactagaggc cctccgctgg gaagcacttg aggtagggca ggaggggggc 4549 tgtgacccct gccctttccc cgccagagac ctcgggctct cagcacattc cacaggctcc 4609 tgagtccccg aggcctgggc cagcttgggc aagccaagat cagatgtctc tgtgttcggg 4669 aaggtctccg tgtgggaaag cccttggggg atcccgggtg aggagtgttg ccccatccag 4729 agaatgaatg agttccttta agtgccaccg ccagcaagcc cagaggcaca cagtccgagt 4789 gcacccgctt agcctttaca ttcctctcca ccgacaaaag gaaggggaaa ctcaatcagc 4849 aggacttcag aaagggcctt gtgtttatag ctttgtcaag taaatttgga cgcagctgga 4909 gcacaggccc tgtttgtttg cacataataa tcttgtttat cactttaaaa aattcagtaa 4969 tatctcagca gtcaggcttc tggttgtgaa atcacattgt atgggattta taccaaatta 5029 tgtatttgct aaacattcac tgcacacgtg tacagcggag tacgaaaagg aacgttgtcc 5089 acaggggatt tatggataca acagcaaaca ttttataaac tatgcacatg cattacacac 5149 atgcacacac atatgcacac acatgtgcaa acatagccac ttttttgtca agagttaccc 5209 tttggggctc cttaaaccag aatgggagtt tgaaagagag atcatactcc agctgaagtt 5269 tgttgaccct tttctaaaat taaaaagatc aaatttagta tttgctggat atgcagggag 5329 atgagactct tttaatctca aaataaacag attctttcaa g 5370 <210> 19 <211> 5891 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1872) <400> 19 gag ggg cag gag cct gct ggt tgt gga gat ccc cag ggg gga cag ccc 48 Glu Gly Gln Glu Pro Ala Gly Cys Gly Asp Pro Gln Gly Gly Gln Pro 1 5 10 15 cgg cac agc ctg cac ctc aca gcc ctg gtg cag ctg gtg aag gag atc 96 Arg His Ser Leu His Leu Thr Ala Leu Val Gln Leu Val Lys Glu Ile 20 25 30 cca gag ttc ttg ttt gga gaa gtc aag ggc gct atg gac agc ccc gag 144 Pro Glu Phe Leu Phe Gly Glu Val Lys Gly Ala Met Asp Ser Pro Glu 35 40 45 agc gag agc cgg gga gcc agc ctg gat gga gag aga gcg agc ccc gag 192 Ser Glu Ser Arg Gly Ala Ser Leu Asp Gly Glu Arg Ala Ser Pro Glu 50 55 60 gct gcg gca aga gag ccc tgc cct ctc cga ggc ctg ctc agc tgc ctt 240 Ala Ala Ala Arg Glu Pro Cys Pro Leu Arg Gly Leu Leu Ser Cys Leu 65 70 75 80 cca gac ggc cct acc agc cag ccc cac ctg gcc acc acg ccc acc gac 288 Pro Asp Gly Pro Thr Ser Gln Pro His Leu Ala Thr Thr Pro Thr Asp 85 90 95 agc tcg tgt tcc agt ggc cca act ggt gac ggg gtc cag gga agt cct 336 Ser Ser Cys Ser Ser Gly Pro Thr Gly Asp Gly Val Gln Gly Ser Pro 100 105 110 ctc ccc atc aaa act gcc gac aaa ccg tgg cct aca agg aag gaa ggc 384 Leu Pro Ile Lys Thr Ala Asp Lys Pro Trp Pro Thr Arg Lys Glu Gly 115 120 125 cca gga gcc ctg ggc ggg gag ccc agc cct ccc acc cat agc ccc agc 432 Pro Gly Ala Leu Gly Gly Glu Pro Ser Pro Pro Thr His Ser Pro Ser 130 135 140 agg agg aag agc cac aga gga cag gag aga ggg acc tca gag gcc gga 480 Arg Arg Lys Ser His Arg Gly Gln Glu Arg Gly Thr Ser Glu Ala Gly 145 150 155 160 att tct cct ggg aac agc ccc ttg caa ggc ctc atc aac tgt ctg aag 528 Ile Ser Pro Gly Asn Ser Pro Leu Gln Gly Leu Ile Asn Cys Leu Lys 165 170 175 gaa atc ctt gtg cct ggg ccc cgg cac ccc gag aca tcc cca agc ttc 576 Glu Ile Leu Val Pro Gly Pro Arg His Pro Glu Thr Ser Pro Ser Phe 180 185 190 ttg cca cct ctc cct agc ctg ggc acg tcc agg cta acc aga gca gac 624 Leu Pro Pro Leu Pro Ser Leu Gly Thr Ser Arg Leu Thr Arg Ala Asp 195 200 205 ctg ggg cct ggg agc ccg ccc tgg gca gtg aag acc gag gcg gtt tca 672 Leu Gly Pro Gly Ser Pro Pro Trp Ala Val Lys Thr Glu Ala Val Ser 210 215 220 ggg gat tgt ccc ctc cag ggt ctg cta cac tgt ctg aag gag ctc ccc 720 Gly Asp Cys Pro Leu Gln Gly Leu Leu His Cys Leu Lys Glu Leu Pro 225 230 235 240 gag gcc cag gac agg cat ccc agt ccc tca gga gtg ggg aac cga cgg 768 Glu Ala Gln Asp Arg His Pro Ser Pro Ser Gly Val Gly Asn Arg Arg 245 250 255 cta cag gag aat cca gga gcc tgg aaa agg ggt tct gga ggg cct gga 816 Leu Gln Glu Asn Pro Gly Ala Trp Lys Arg Gly Ser Gly Gly Pro Gly 260 265 270 tac ctc ctg acc cct cct ccc cat cct gat ctt gga gct ggc ggt ctg 864 Tyr Leu Leu Thr Pro Pro Pro His Pro Asp Leu Gly Ala Gly Gly Leu 275 280 285 ctc tct gtg aag atg gag aac agc tgg gtc cag agc ccc cca gga cct 912 Leu Ser Val Lys Met Glu Asn Ser Trp Val Gln Ser Pro Pro Gly Pro 290 295 300 gca tcc tgt cag cct ggc agg cag ccc ctc agt ccc tca gcc act gga 960 Ala Ser Cys Gln Pro Gly Arg Gln Pro Leu Ser Pro Ser Ala Thr Gly 305 310 315 320 gac acc aga ggg gtc ccc caa ccc agc tgg ggc cct gag gct caa gct 1008 Asp Thr Arg Gly Val Pro Gln Pro Ser Trp Gly Pro Glu Ala Gln Ala 325 330 335 gcc agt gcc tca agc tca ccg ctg gaa gcc ctg gaa gcc tgt ctg aag 1056 Ala Ser Ala Ser Ser Ser Pro Leu Glu Ala Leu Glu Ala Cys Leu Lys 340 345 350 ggc att ccc cca aat ggg tcg tca cct tcc cag ctg cca ccc act tct 1104 Gly Ile Pro Pro Asn Gly Ser Ser Pro Ser Gln Leu Pro Pro Thr Ser 355 360 365 tgt tcc cag aac ccc cag cca gga gac tct agg tct cag aag cct gaa 1152 Cys Ser Gln Asn Pro Gln Pro Gly Asp Ser Arg Ser Gln Lys Pro Glu 370 375 380 ctg caa ccc cac aga tca cac agt gaa gaa gcg acc aga gag cct gtt 1200 Leu Gln Pro His Arg Ser His Ser Glu Glu Ala Thr Arg Glu Pro Val 385 390 395 400 ctg cct ctg ggt ctg cag agc tgt gtg aga gat ggc ccc agc agg ccc 1248 Leu Pro Leu Gly Leu Gln Ser Cys Val Arg Asp Gly Pro Ser Arg Pro 405 410 415 ctg gcc ccc cga gga acc ccc acc agc ttc tcc tca tcc agc agc acc 1296 Leu Ala Pro Arg Gly Thr Pro Thr Ser Phe Ser Ser Ser Ser Ser Thr 420 425 430 gac tgg gac ctg gat ttt ggg agt cct gtg ggg aac cag ggg cag cat 1344 Asp Trp Asp Leu Asp Phe Gly Ser Pro Val Gly Asn Gln Gly Gln His 435 440 445 cct gga aaa gga agc cca cca gga agc tcc cca ctg cag ggt ctg gag 1392 Pro Gly Lys Gly Ser Pro Pro Gly Ser Ser Pro Leu Gln Gly Leu Glu 450 455 460 aat tgt ctc aag gag ata cct gtg cct gtg ctg cgg cct gcc tgg ccc 1440 Asn Cys Leu Lys Glu Ile Pro Val Pro Val Leu Arg Pro Ala Trp Pro 465 470 475 480 tgc tcc tca gca gca gac agg gga ccg agg aga gca gag ccc agg aac 1488 Cys Ser Ser Ala Ala Asp Arg Gly Pro Arg Arg Ala Glu Pro Arg Asn 485 490 495 tgg aca gca gac aag gaa ggg tct gcc ccc aag ccc tcc ccg ctg cac 1536 Trp Thr Ala Asp Lys Glu Gly Ser Ala Pro Lys Pro Ser Pro Leu His 500 505 510 tgc ctg gag agc gcc ctg agg ggg atc ttg cct gta agg ccc ttg cgc 1584 Cys Leu Glu Ser Ala Leu Arg Gly Ile Leu Pro Val Arg Pro Leu Arg 515 520 525 ttc gcc tgc gtg gga ggc ccc agc ccc agc ccc agc ccc ggc tcc agc 1632 Phe Ala Cys Val Gly Gly Pro Ser Pro Ser Pro Ser Pro Gly Ser Ser 530 535 540 tcg agc ttc agc ggc tct gaa gga gaa gac ccg agg cca gag cct gag 1680 Ser Ser Phe Ser Gly Ser Glu Gly Glu Asp Pro Arg Pro Glu Pro Glu 545 550 555 560 ctc tgg aag ccg ctc ccc cag gag agg gac cgc ctt ccc agc tgt aag 1728 Leu Trp Lys Pro Leu Pro Gln Glu Arg Asp Arg Leu Pro Ser Cys Lys 565 570 575 cct cct gtc cct ctg tcc cca tgt cct ggt ggg acc cct gct ggc agc 1776 Pro Pro Val Pro Leu Ser Pro Cys Pro Gly Gly Thr Pro Ala Gly Ser 580 585 590 agt ggc ggc agc cct ggt gaa gac ccc agg aga aca gag ccc agg tac 1824 Ser Gly Gly Ser Pro Gly Glu Asp Pro Arg Arg Thr Glu Pro Arg Tyr 595 600 605 agc tca gga tcc ctg ccc ggt ttc tca gct gga gaa aag gcc cag ggt 1872 Ser Ser Gly Ser Leu Pro Gly Phe Ser Ala Gly Glu Lys Ala Gln Gly 610 615 620 tagtgaagca tccagaggcc tggagcttgg acatggaaga cccagagttg cagccaagac 1932 ccatgagagg ctgctccccc agggcccgcc tgagctgccc agtgagtctc cccctccgga 1992 gctgccccct ccggaagctg cgcctcctgt gttgccagcc tcctccctgc agccgccatg 2052 ccactgtggg aagcccctgc agcaggagct gcacagcctc ggtgctgccc ttgcggagaa 2112 gctggatcgg ctcgccacag cgctggcagg cctggctcag gaagtggcca ccatgaggac 2172 ccaggtgaat cggctgggga ggcgccccca aggccctggg ccaatgggcc aagcttcctg 2232 gatgtggacc ctcccacggg gacctcgctg ggctcatggc cctggtcaca gacatctgcc 2292 ctactggagg cagaagggac ccacgaggcc taaaccaaag atcctgcgtg gccagggaga 2352 gagctgcagg gctggtgacc tgcaaggact ctccagaggg accgctcgcc gggcacgtcc 2412 gctgcctcca gacgctcccc cggcagaacc tcctgggctc cactgcagct cttcccagca 2472 gctgctgtcc tctacaccca gctgccatgc tgcgccgcct gcacaccccc tcctcgcaca 2532 taccgggggc caccagagcc cccttccccc tttagtgcct gctgccttac ccctgcaggg 2592 agcctctcct cctgcagcca gtgcagatgc agacgtgccg acctcaggag tggcaccaga 2652 cgggatccca gagcggccca aggagccgag cagcctgctg ggaggagtgc agagggccct 2712 ccaggaagaa ctgtggggtg gggagcacag ggacccgaga tggggggcgc attgatggca 2772 ttcctcttct ccacatctgc tcgttcttgc cgagggtgca gtggtggcgt ggaagccctg 2832 tcaccccacc ccaggccacc ctctcccaga ggacgccatc tcccttactg ttgctgggag 2892 cctcgccctt tgtcccaact gggtagagcc cccaggtgct gtttgctcag gaggctgctg 2952 tgggggtgcc ttcctcagcc tctggccctc ttggctcaga ttcaatcaaa tgttgcttcc 3012 ctctcctgtc tttcccactg gagccgccca agcttgtagg tgggtggtgt gcataggcca 3072 cgtgtgcccc acatatgcag ggggtgcccc acacagctag agcggccagg agagcgcctc 3132 ctaaccacca gccgttcctg atctcaggag ccttgaaggg ctgggctctt gccttcctgg 3192 agtaaatatt ggcacagatt tcatttgaga gaactcagcc ccctggtcta agctggactt 3252 acctctgtgg attctgaaat taaagaagtg agttgctaag gaaggccctg actcctatag 3312 aagggaggtc catgtgggcc cacgctgggg cggggctggt tgtgccacca gcacgctgcc 3372 tcgtctccca gacatcctcg agaacattca ggagtgtgcc aggaagggtg gggcaattcc 3432 cacaggactc ctggggcaca ctctgagtcc cctggggctg cctcacagag gaaccctgcc 3492 tgggcagctt caacagcagc acatattgtc tctgtcctgg aggccagaag tctacaatcc 3552 aggtgtcagg ttcagttcct gctttgggct gggagggagg atcggtcccg gacctctccc 3612 cttgacctgt agatggctgt cttcctgttc agatggtgtt ttctacacag ctgtctccag 3672 atttcccctt catatcaggg cagcagttgt atggggttat gacccaccct aatgacttca 3732 ttttaacctg attacctctc taaacacccc ctctccaagt gaggtcacat ttggaggtac 3792 tggaggttag gccttcacca tacacatttg gggaggggca cagttcagcc tgtaacacac 3852 caaacgggct gggccagtct tcctggtttt gtcttgggaa aagacatgac caggtatcac 3912 tagcccactt ctgtcctggt taccggaatg tgcctgctcc cagcccgctc agctggcgct 3972 tggcaatgcg ttggaaccag cctgcctgtc attcccttgc atcatcttcc caagaggcag 4032 aatgcaacct gtgtgccccc aaatccctta tttgacctga ggtggtttca ggacctgtat 4092 gtgcacctgt tgactggcag ggccagcctg gtgtggactg gcagggccag cctggtgtgg 4152 actggcacac ttggccctgt cctcaggtcc ctgaggagcc tgggacacca gcactgtggc 4212 ctggggcaat gctggctgcc caccatgact acaggagcag tgccttgtgg ctgcagcgcc 4272 cagtgtgtcc ctcaagtcag ggtcactggg gacacactcg gggcctaagt gccctgcagc 4332 tgagcttggg agctgaagcc cttgctcttt gccaccctgt agaagcagca gggcaaggac 4392 acctgtcaga ggggaatgcc cgcaacagac tgaacatcac aaagggatgg gaagatgctt 4452 tcaggactag agtgagcccc gaggtgactg tctggaaaca gatcctaaga ccatacaagt 4512 aggatgtttg ttgaaatacg gaggctgttc gctcacagcc gtgcttgcac agaatcagga 4572 agggaaagtt tctaggttgc tcctgcctga ggagctctcc ttgtaataag cagggagcag 4632 tgccgggcac gtttcagagc cacggcaagg ggtgggacac agtttcagag gggggttgag 4692 aagcgaaact gcccctgccc tgactctggc tgtgaggaga ggactcttgc ccacccctgc 4752 tgcagctggt gcagtcccat cctgcctgcc tgtcctccca ttctcctttc ccttctaagc 4812 aggggtcact gggctgtcga ctcaatggga gggggggtca ccttacactt ctgtgtggca 4872 cattaaggtg gttttgcttt gctggcttcc gaaacagcca ccacgcaaac cctagttgac 4932 aggcacgact gaacaaatga gcatggtggc tgtaagtgac tgtcacagtt aggcagcctt 4992 caaccagcag agctaggaag agagctcgag ccctcaccag tgccgccagc actcggcgca 5052 tcctcaccct gggcacagat gccccctccc agcctttgcc tgctgggaca gaccagggta 5112 ttcaggactg agcctggtct aggtggtcca gacccagttg gaccatataa taagtttaaa 5172 gttgttttaa gaatgtggat tctaagtaat aagtggtaag aagttccatg gtctgcagct 5232 gcgttcctcc tgcagaagca gttccctagg tctaggtctc caggacctgt ccacagtcac 5292 tgaaacgcct tctagaattg atctagtgga aaatctagat gcagtttagg tctttggcac 5352 tgtgcccatc tcctttaaga actgtgcagt gtggcttgga agaggaaatg tggtcccttt 5412 gatgggagaa actgaaggac ctttttgaac tcaaaggagc tccagggttt ggaattgggg 5472 gcagagaagg ctccaggctg ctcattccat cctgggtgag ccgaacgggt cctggctgat 5532 ctgagtgcga ccttcccagt ctgccagcca gagtccccca gcaggcagga acatgtgaag 5592 gttccgcttc aaaatatgaa tgaatgggct cctcgtgccc ctattatttt ctggccaccc 5652 ccaggggtcc tgatggaagg gaggctggcc tgcggggtgc aagaaccacg attcactgct 5712 ccccgctgaa ggtgcttggt caagagcagc aggcatgctg ttaacctttg tgcgggtttg 5772 tgttttggat gtggctccta tgcacaacct atggatttta tctcataaac catcttgaca 5832 gattttgctc gtcaactggg agcccttaat ccatttaaat gtaattgact gactgattt 5891 <210> 20 <211> 3832 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(3610) <400> 20 g gcg gca gcg gcg gcg gtg ggc aac gcg gtg ccc tgc ggg gcc cgg cct 49 Ala Ala Ala Ala Ala Val Gly Asn Ala Val Pro Cys Gly Ala Arg Pro 1 5 10 15 tgc ggg gtc cgg cct gac ggg cag ccc aag ccc ggg ccg cag ccg cgc 97 Cys Gly Val Arg Pro Asp Gly Gln Pro Lys Pro Gly Pro Gln Pro Arg 20 25 30 gcg ctc ctt gcc gcc ggg ccg gcg ctc ata gcg aac ggt gac gag ctg 145 Ala Leu Leu Ala Ala Gly Pro Ala Leu Ile Ala Asn Gly Asp Glu Leu 35 40 45 gtg gct gcc gtg tgg ccg tac cgg cgg ttg gcg ctg ttg cgg cgc ctc 193 Val Ala Ala Val Trp Pro Tyr Arg Arg Leu Ala Leu Leu Arg Arg Leu 50 55 60 acg gtg ctg cca ttc gcc ggg ctg ctt tac ccg gcc tgg ttg ggt gcc 241 Thr Val Leu Pro Phe Ala Gly Leu Leu Tyr Pro Ala Trp Leu Gly Ala 65 70 75 80 gca gcc gct ggc tgc tgg ggc tgg ggc agc agt tgg gtg cag atc ccc 289 Ala Ala Ala Gly Cys Trp Gly Trp Gly Ser Ser Trp Val Gln Ile Pro 85 90 95 gaa gct gcg ctg ctc gtg ctt gcc acc atc tgc ctc gcg cac gcg ctc 337 Glu Ala Ala Leu Leu Val Leu Ala Thr Ile Cys Leu Ala His Ala Leu 100 105 110 act gtc ctc tcg ggg cat tgg tct gtg cac gcg cat tgc gcg ctc acc 385 Thr Val Leu Ser Gly His Trp Ser Val His Ala His Cys Ala Leu Thr 115 120 125 tgc acc ccg gag tac gac ccc agc aaa gcg acc ttt gtg aag gtg gtg 433 Cys Thr Pro Glu Tyr Asp Pro Ser Lys Ala Thr Phe Val Lys Val Val 130 135 140 cca acc ccc aac aat ggc tcc acg gag ctc gtg gcc ctg cac cgc aat 481 Pro Thr Pro Asn Asn Gly Ser Thr Glu Leu Val Ala Leu His Arg Asn 145 150 155 160 gag ggc gaa gac ggg ctt gag gtg ctg tcc ttc gaa ttc cag aag atc 529 Glu Gly Glu Asp Gly Leu Glu Val Leu Ser Phe Glu Phe Gln Lys Ile 165 170 175 aag tat tcc tac gat gcc ctg gag aag aag cag ttt ctc ccc gtg gcc 577 Lys Tyr Ser Tyr Asp Ala Leu Glu Lys Lys Gln Phe Leu Pro Val Ala 180 185 190 ttt cct gtg gga aac gcc ttc tca tac tat cag agc aac aga ggc ttc 625 Phe Pro Val Gly Asn Ala Phe Ser Tyr Tyr Gln Ser Asn Arg Gly Phe 195 200 205 cag gaa gac tca gag atc cga gca gct gag aag aaa ttt ggg agc aac 673 Gln Glu Asp Ser Glu Ile Arg Ala Ala Glu Lys Lys Phe Gly Ser Asn 210 215 220 aag gcc gag atg gtg gtg cct gac ttc tcg gag ctt ttc aag gag aga 721 Lys Ala Glu Met Val Val Pro Asp Phe Ser Glu Leu Phe Lys Glu Arg 225 230 235 240 gcc aca gcc ccc ttc ttt gta ttt cag gtg ttc tgt gtg ggg ctc tgg 769 Ala Thr Ala Pro Phe Phe Val Phe Gln Val Phe Cys Val Gly Leu Trp 245 250 255 tgc ctg gat gag tac tgg tac tac agc gtc ttt acg cta tcc atg ctg 817 Cys Leu Asp Glu Tyr Trp Tyr Tyr Ser Val Phe Thr Leu Ser Met Leu 260 265 270 gtg gcg ttc gag gcc tcg ctg gtg cag cag cag atg cgg aac atg tcg 865 Val Ala Phe Glu Ala Ser Leu Val Gln Gln Gln Met Arg Asn Met Ser 275 280 285 gag atc cgg aag atg ggc aac aag ccc cac atg atc cag gtc tac cga 913 Glu Ile Arg Lys Met Gly Asn Lys Pro His Met Ile Gln Val Tyr Arg 290 295 300 agc cgc aag tgg agg ccc att gcc agt gat gag atc gta cca ggg gac 961 Ser Arg Lys Trp Arg Pro Ile Ala Ser Asp Glu Ile Val Pro Gly Asp 305 310 315 320 atc gtc tcc atc ggc cgc tcc cca cag gag aac ctg gtg cca tgt gac 1009 Ile Val Ser Ile Gly Arg Ser Pro Gln Glu Asn Leu Val Pro Cys Asp 325 330 335 gtg ctt ctg ctg cga ggc cgc tgc atc gta gac gag gcc atg ctc acg 1057 Val Leu Leu Leu Arg Gly Arg Cys Ile Val Asp Glu Ala Met Leu Thr 340 345 350 ggg gag tcc gtg cca cag atg aag gag ccc atc gaa gac ctc agc cca 1105 Gly Glu Ser Val Pro Gln Met Lys Glu Pro Ile Glu Asp Leu Ser Pro 355 360 365 gac cgg gtg ctg gac ctc cag gct gat tcc cgg ctg cac gtc atc ttc 1153 Asp Arg Val Leu Asp Leu Gln Ala Asp Ser Arg Leu His Val Ile Phe 370 375 380 ggg ggc acc aag gtg gtg cag cac atc ccc cca cag aaa gcc acc acg 1201 Gly Gly Thr Lys Val Val Gln His Ile Pro Pro Gln Lys Ala Thr Thr 385 390 395 400 ggc ctg aag ccg gtt gac agc ggg tgc gtg gcc tac gtc ctg cgg acc 1249 Gly Leu Lys Pro Val Asp Ser Gly Cys Val Ala Tyr Val Leu Arg Thr 405 410 415 gga ttc aac aca tcc cag ggc aag ctg ctg cgc acc atc ctc ttc ggg 1297 Gly Phe Asn Thr Ser Gln Gly Lys Leu Leu Arg Thr Ile Leu Phe Gly 420 425 430 gtc aag agg gtg act gcg aac aac ctg gag acc ttc atc ttc atc ctc 1345 Val Lys Arg Val Thr Ala Asn Asn Leu Glu Thr Phe Ile Phe Ile Leu 435 440 445 ttc ctc ctg gtg ttt gcc atc gct gca gct gcc tat gta tgg att gaa 1393 Phe Leu Leu Val Phe Ala Ile Ala Ala Ala Ala Tyr Val Trp Ile Glu 450 455 460 ggt acc aag gac ccc agc cgg aac cgc tac aag ctg ttt ctg gag tgc 1441 Gly Thr Lys Asp Pro Ser Arg Asn Arg Tyr Lys Leu Phe Leu Glu Cys 465 470 475 480 acc ctg atc ctc acc tcg gtc gtg cct cct gag ctg ccc atc gag ctg 1489 Thr Leu Ile Leu Thr Ser Val Val Pro Pro Glu Leu Pro Ile Glu Leu 485 490 495 tcc ctg gcc gtc aac acc tcc ctc atc gcc ctg gcc aag ctc tac atg 1537 Ser Leu Ala Val Asn Thr Ser Leu Ile Ala Leu Ala Lys Leu Tyr Met 500 505 510 tac tgc aca gag ccc ttc cgg atc ccc ttt gct ggc aag gtc gag gtg 1585 Tyr Cys Thr Glu Pro Phe Arg Ile Pro Phe Ala Gly Lys Val Glu Val 515 520 525 tgc tgc ttt gac aag acg ggg acg ttg acc agt gac agc ctg gtg gtg 1633 Cys Cys Phe Asp Lys Thr Gly Thr Leu Thr Ser Asp Ser Leu Val Val 530 535 540 cgc ggt gtg gcc ggg ctg aga gac ggg aag gag gtg acc cca gtg tcc 1681 Arg Gly Val Ala Gly Leu Arg Asp Gly Lys Glu Val Thr Pro Val Ser 545 550 555 560 agc atc cct gta gaa aca cac cgg gcc ctg gcc tcg tgc cac tcg ctc 1729 Ser Ile Pro Val Glu Thr His Arg Ala Leu Ala Ser Cys His Ser Leu 565 570 575 atg cag ctg gac gac ggc acc ctc gtg ggt gac cct cta gag aag gcc 1777 Met Gln Leu Asp Asp Gly Thr Leu Val Gly Asp Pro Leu Glu Lys Ala 580 585 590 atg ctg acg gcc gtg gac tgg acg ctg acc aaa gat gag aaa gta ttc 1825 Met Leu Thr Ala Val Asp Trp Thr Leu Thr Lys Asp Glu Lys Val Phe 595 600 605 ccc cga agt att aaa act cag ggg ctg aaa att cac cag cgc ttt cat 1873 Pro Arg Ser Ile Lys Thr Gln Gly Leu Lys Ile His Gln Arg Phe His 610 615 620 ttt gcc agt gcc ctg aag cga atg tcc gtg ctt gcc tcg tat gag aag 1921 Phe Ala Ser Ala Leu Lys Arg Met Ser Val Leu Ala Ser Tyr Glu Lys 625 630 635 640 ctg ggc tcc acc gac ctc tgc tac atc gcg gcc gtg aag ggg gcc ccc 1969 Leu Gly Ser Thr Asp Leu Cys Tyr Ile Ala Ala Val Lys Gly Ala Pro 645 650 655 gaa act ctg cac tcc atg ttc tcc cag tgc ccg ccc gac tac cac cac 2017 Glu Thr Leu His Ser Met Phe Ser Gln Cys Pro Pro Asp Tyr His His 660 665 670 atc cac acc gag atc tcc cgg gaa gga gcc cgc gtc ctg gcg ctg ggg 2065 Ile His Thr Glu Ile Ser Arg Glu Gly Ala Arg Val Leu Ala Leu Gly 675 680 685 tac aag gag ctg gga cac ctc act cac cag cag gcc cgg gag gtc aag 2113 Tyr Lys Glu Leu Gly His Leu Thr His Gln Gln Ala Arg Glu Val Lys 690 695 700 cgg gag gcc ctg gag tgc agc ctc aag ttc gtc ggc ttc att gtg gtc 2161 Arg Glu Ala Leu Glu Cys Ser Leu Lys Phe Val Gly Phe Ile Val Val 705 710 715 720 tcc tgc ccg ctc aag gct gac tcc aag gcc gtg atc cgg gag atc cag 2209 Ser Cys Pro Leu Lys Ala Asp Ser Lys Ala Val Ile Arg Glu Ile Gln 725 730 735 aat gcg tcc cac cgg gtg gtc atg atc acg gga gac aac ccg ctc act 2257 Asn Ala Ser His Arg Val Val Met Ile Thr Gly Asp Asn Pro Leu Thr 740 745 750 gca tgc cac gtg gcc cag gag ctg cac ttc att gaa aag gcc cac acg 2305 Ala Cys His Val Ala Gln Glu Leu His Phe Ile Glu Lys Ala His Thr 755 760 765 ctg atc ctg cag cct ccc tcc gag aaa ggc cgg cag tgc gag tgg cgc 2353 Leu Ile Leu Gln Pro Pro Ser Glu Lys Gly Arg Gln Cys Glu Trp Arg 770 775 780 tcc att gac ggc agc atc gtg ctg ccc ctg gcc cgg ggc tcc cca aag 2401 Ser Ile Asp Gly Ser Ile Val Leu Pro Leu Ala Arg Gly Ser Pro Lys 785 790 795 800 gca ctg gcc ctg gag tac gca ctg tgc ctc aca ggc gac ggc ttg gcc 2449 Ala Leu Ala Leu Glu Tyr Ala Leu Cys Leu Thr Gly Asp Gly Leu Ala 805 810 815 cac ctg cag gcc acc gac ccc cag cag ctg ctc cgc ctc atc ccc cat 2497 His Leu Gln Ala Thr Asp Pro Gln Gln Leu Leu Arg Leu Ile Pro His 820 825 830 gtg cag gtg ttc gcc cgt gtg gct ccc aag cag aag gag ttt gtc atc 2545 Val Gln Val Phe Ala Arg Val Ala Pro Lys Gln Lys Glu Phe Val Ile 835 840 845 acc agc ctg aag gag ctg ggc tac gtg acc ctc atg tgt ggg gat ggc 2593 Thr Ser Leu Lys Glu Leu Gly Tyr Val Thr Leu Met Cys Gly Asp Gly 850 855 860 acc aac gac gtg ggc gcc ctg aag cat gct gac gtg ggt gtg gcg ctc 2641 Thr Asn Asp Val Gly Ala Leu Lys His Ala Asp Val Gly Val Ala Leu 865 870 875 880 ttg gcc aat gcc cct gag cgg gtt gtc gag cgg cga cgg cgg ccc cgg 2689 Leu Ala Asn Ala Pro Glu Arg Val Val Glu Arg Arg Arg Arg Pro Arg 885 890 895 gac agc cca acc ctg agc aac agt ggc atc aga gcc acc tcc agg aca 2737 Asp Ser Pro Thr Leu Ser Asn Ser Gly Ile Arg Ala Thr Ser Arg Thr 900 905 910 gcc aag cag cgg tcg ggg ctc cct ccc tcc gag gag cag cca acc tcc 2785 Ala Lys Gln Arg Ser Gly Leu Pro Pro Ser Glu Glu Gln Pro Thr Ser 915 920 925 cag agg gac cgc ctg agc cag gtg ctg cga gac ctc gag gac gag agt 2833 Gln Arg Asp Arg Leu Ser Gln Val Leu Arg Asp Leu Glu Asp Glu Ser 930 935 940 acg ccc att gtg aaa ctg ggg gat gcc agc atc gca gca ccc ttc acc 2881 Thr Pro Ile Val Lys Leu Gly Asp Ala Ser Ile Ala Ala Pro Phe Thr 945 950 955 960 tcc aag ctc tca tcc atc cag tgc atc tgc cac gtg atc aag cag ggc 2929 Ser Lys Leu Ser Ser Ile Gln Cys Ile Cys His Val Ile Lys Gln Gly 965 970 975 cgc tgc acg ctg gtg acc acg cta cag atg ttc aag atc ctg gcg ctc 2977 Arg Cys Thr Leu Val Thr Thr Leu Gln Met Phe Lys Ile Leu Ala Leu 980 985 990 aat gcc ctc atc ctg gcc tac agc cag agc gtc ctc tac ctg gag gga 3025 Asn Ala Leu Ile Leu Ala Tyr Ser Gln Ser Val Leu Tyr Leu Glu Gly 995 1000 1005 gtc aag ttc agt gac ttc cag gcc acc cta cag ggg ctg ctg ctg gcc 3073 Val Lys Phe Ser Asp Phe Gln Ala Thr Leu Gln Gly Leu Leu Leu Ala 1010 1015 1020 ggc tgc ttc ctc ttc atc tcc cgt tcc aag ccc ctc aag acc ctc tcc 3121 Gly Cys Phe Leu Phe Ile Ser Arg Ser Lys Pro Leu Lys Thr Leu Ser 1025 1030 1035 1040 cga gaa cgg ccc ctg ccc aac atc ttc aac ctg tac acc atc ctc acc 3169 Arg Glu Arg Pro Leu Pro Asn Ile Phe Asn Leu Tyr Thr Ile Leu Thr 1045 1050 1055 gtc atg ctc cag ttc ttt gtg cac ttc ctg agc ctt gtc tac ctg tac 3217 Val Met Leu Gln Phe Phe Val His Phe Leu Ser Leu Val Tyr Leu Tyr 1060 1065 1070 cgt gag gcc cag gcc cgg agc ccc gag aag cag gag cag ttc gtg gac 3265 Arg Glu Ala Gln Ala Arg Ser Pro Glu Lys Gln Glu Gln Phe Val Asp 1075 1080 1085 ttg tac aag gag ttt gag cca agc ctg gtc aac agc acc gtc tac atc 3313 Leu Tyr Lys Glu Phe Glu Pro Ser Leu Val Asn Ser Thr Val Tyr Ile 1090 1095 1100 atg gcc atg gcc atg cag atg gcc acc ttc gcc atc aat tac aaa ggc 3361 Met Ala Met Ala Met Gln Met Ala Thr Phe Ala Ile Asn Tyr Lys Gly 1105 1110 1115 1120 ccg ccc ttc atg gag agc ctg ccc gag aac aag ccc ctg gtg tgg agt 3409 Pro Pro Phe Met Glu Ser Leu Pro Glu Asn Lys Pro Leu Val Trp Ser 1125 1130 1135 ctg gca gtt tca ctc ctg gcc atc att ggc ctg ctc ctc ggc tcc tcg 3457 Leu Ala Val Ser Leu Leu Ala Ile Ile Gly Leu Leu Leu Gly Ser Ser 1140 1145 1150 ccc gac ttc aac agc cag ttt ggc ctc gtg gac atc cct gtg gag ttc 3505 Pro Asp Phe Asn Ser Gln Phe Gly Leu Val Asp Ile Pro Val Glu Phe 1155 1160 1165 aag ctg gtc att gcc cag gtc ctg ctc ctg gac ttc tgc ctg gcg ctc 3553 Lys Leu Val Ile Ala Gln Val Leu Leu Leu Asp Phe Cys Leu Ala Leu 1170 1175 1180 ctg gcc gac cgc gtc ctg cag ttc ttc ctg ggg acc ccg aag ctg aaa 3601 Leu Ala Asp Arg Val Leu Gln Phe Phe Leu Gly Thr Pro Lys Leu Lys 1185 1190 1195 1200 gtg cct tcc tgagatggca gtgctggtac ccactgccca ccctggctgc 3650 Val Pro Ser cgctgggcgg gaaccccaac agggccccgg gagggaaccc tgcccccaac cccccacagc 3710 aaggctgtac agtctcgccc ttggaagact gagctgggac ccccacagcc atccgctggc 3770 ttggccagca gaaccagccc caagccagca cctttggtaa ataaagcagc atctgagatt 3830 tt 3832 <210> 21 <211> 4270 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (83)..(1438) <400> 21 caaggggcca ggaccctgag ttttattggg ccttgactaa tgtgcctcct catctgtgtc 60 ctcaccctca ttgtggactt ag gtt tca gtt atc tca gag gca gac cca cag 112 Val Ser Val Ile Ser Glu Ala Asp Pro Gln 1 5 10 gct ctg ctc cag gcc atg aag gac ctg gac ggc atg gat gct gat atc 160 Ala Leu Leu Gln Ala Met Lys Asp Leu Asp Gly Met Asp Ala Asp Ile 15 20 25 tta ggt ctg aag aaa tct aat tca gcc cct agc aaa aaa gct gca aag 208 Leu Gly Leu Lys Lys Ser Asn Ser Ala Pro Ser Lys Lys Ala Ala Lys 30 35 40 gac cct ggg aaa gga gag ctg ccc aac cac ccc aag cct gca ggg ggt 256 Asp Pro Gly Lys Gly Glu Leu Pro Asn His Pro Lys Pro Ala Gly Gly 45 50 55 gcc att ccc acc aag aag tca ctt ccg tct ccc agc agc tct ggg cat 304 Ala Ile Pro Thr Lys Lys Ser Leu Pro Ser Pro Ser Ser Ser Gly His 60 65 70 cag aac agg agg ttt tcc tct gaa gac ttg gaa gac cca ttg gga gga 352 Gln Asn Arg Arg Phe Ser Ser Glu Asp Leu Glu Asp Pro Leu Gly Gly 75 80 85 90 ctt ctc tcc tat gat gaa gga gga atc acc aag cag ccg cct gtg aca 400 Leu Leu Ser Tyr Asp Glu Gly Gly Ile Thr Lys Gln Pro Pro Val Thr 95 100 105 cag agt aaa aca gct tct gac aag agc ccc agc aca gtg aga gat caa 448 Gln Ser Lys Thr Ala Ser Asp Lys Ser Pro Ser Thr Val Arg Asp Gln 110 115 120 ggt ccc tct att cct cta act cct ggg gac acc ccc atc cga aaa aaa 496 Gly Pro Ser Ile Pro Leu Thr Pro Gly Asp Thr Pro Ile Arg Lys Lys 125 130 135 gaa gaa ttg ttg ttt gat gat ggg gat gac atc atg gcc acc ttg ggg 544 Glu Glu Leu Leu Phe Asp Asp Gly Asp Asp Ile Met Ala Thr Leu Gly 140 145 150 ttt gga gac agc ccc aaa gca gag aag agg cag ata gga gac cag gaa 592 Phe Gly Asp Ser Pro Lys Ala Glu Lys Arg Gln Ile Gly Asp Gln Glu 155 160 165 170 ggg cct cgc cct gct cgc tcc acg ctg gat gag ctg ctg ggt cga ggc 640 Gly Pro Arg Pro Ala Arg Ser Thr Leu Asp Glu Leu Leu Gly Arg Gly 175 180 185 atg gcc acc aaa ctc ctg gcc cgc ccg ggc acc ggg gag cac agg gag 688 Met Ala Thr Lys Leu Leu Ala Arg Pro Gly Thr Gly Glu His Arg Glu 190 195 200 ttc aag cta gac aag aag tac cag agg cca cag gac agt gaa gat atg 736 Phe Lys Leu Asp Lys Lys Tyr Gln Arg Pro Gln Asp Ser Glu Asp Met 205 210 215 tgg ggt gac gag gac ttc acc ttt gga gcc tat cag ccc act gtg gtc 784 Trp Gly Asp Glu Asp Phe Thr Phe Gly Ala Tyr Gln Pro Thr Val Val 220 225 230 tcc tct gag ggc cgg cag tcc cgc cgg cag tct gtc agt agg ttc ttc 832 Ser Ser Glu Gly Arg Gln Ser Arg Arg Gln Ser Val Ser Arg Phe Phe 235 240 245 250 gca gac agt ggc gca gac ccc aag gga gaa cca ggc tcc aaa cag agc 880 Ala Asp Ser Gly Ala Asp Pro Lys Gly Glu Pro Gly Ser Lys Gln Ser 255 260 265 cct cca atg gct tcc agc ccc atc cag ccc agg aag gga gga gct gac 928 Pro Pro Met Ala Ser Ser Pro Ile Gln Pro Arg Lys Gly Gly Ala Asp 270 275 280 tgg ttg ggc ctc aag gac gag gac ttg gac ctg ttc cct gcc tca ccc 976 Trp Leu Gly Leu Lys Asp Glu Asp Leu Asp Leu Phe Pro Ala Ser Pro 285 290 295 acc aga gag gcc cat cgg gaa agt tca gtg cct gtc acg ccc tca gtg 1024 Thr Arg Glu Ala His Arg Glu Ser Ser Val Pro Val Thr Pro Ser Val 300 305 310 cct cct cct gcg agc cag cac tcc acg cca gct ggg ctg ccc ccc tcc 1072 Pro Pro Pro Ala Ser Gln His Ser Thr Pro Ala Gly Leu Pro Pro Ser 315 320 325 330 agg gca aag cca cca act gaa ggt gca ggg tcc cct gcc aaa gcc agc 1120 Arg Ala Lys Pro Pro Thr Glu Gly Ala Gly Ser Pro Ala Lys Ala Ser 335 340 345 cag gct tcc aag ctg cga gcc tcc aag gag gag aaa gag gac tgg ctg 1168 Gln Ala Ser Lys Leu Arg Ala Ser Lys Glu Glu Lys Glu Asp Trp Leu 350 355 360 agc cat gcc ctg tct cgg aag aag tcc caa ggc ctg gcc aga gag cag 1216 Ser His Ala Leu Ser Arg Lys Lys Ser Gln Gly Leu Ala Arg Glu Gln 365 370 375 cat gct ggg acc tct gag ggc ctg cat ttg gcg ggg aca gcg ggc cat 1264 His Ala Gly Thr Ser Glu Gly Leu His Leu Ala Gly Thr Ala Gly His 380 385 390 ccc cct tct ggc agc ctg acc tgg gcc ttc tgt cac ctt cac ctt gaa 1312 Pro Pro Ser Gly Ser Leu Thr Trp Ala Phe Cys His Leu His Leu Glu 395 400 405 410 cgc tgc ctt tcc tca gcc aac ctc tca cca gca cac aag ggc ttg agc 1360 Arg Cys Leu Ser Ser Ala Asn Leu Ser Pro Ala His Lys Gly Leu Ser 415 420 425 acg cag ctg ctg gag gga gtt ctg gaa caa ctg cac gag aaa gac cgt 1408 Thr Gln Leu Leu Glu Gly Val Leu Glu Gln Leu His Glu Lys Asp Arg 430 435 440 gtg tca ggc ctg gtg tct cgg ggt ccc ctg tgactcagaa ccatgccgcc 1458 Val Ser Gly Leu Val Ser Arg Gly Pro Leu 445 450 tcagcactcc ctacaggttc cccaaagagg ggaacagccc ctggagacct ctcagccact 1518 gagcctgcca cgtgtttccc gagcacccag aaacccacag agccttccgt gcccgtccag 1578 cccctgctcc cagagtccct ggcccggagc ctgctgccga gcacagaata ccagaagcag 1638 ctcctggcag cacaggtgca acttcagtgc agccccgctg agctccaggc cgagctgctg 1698 catagccagg cccggctggc agagctggag gcccaggtgc ggaagctgga gctagaacgg 1758 gcccagcatg agctgctgct ggggagtctg cagcagcagc accaggcaga cctggagctc 1818 atcgagagtg cacacagaag ccgcatcaag gtgctagaaa catcgtacca gcaacgggag 1878 gagcggctcc ggagagagaa cgaagagctg tcagctcggt atctgtcgca gtgccaggag 1938 gccgaacagg cccgtgctga gcttacggcc cagcaccagc ggcgcttggc ggccatagcg 1998 caggagaagg accaggaaat ggagcggctc cgggagctgc agcgggcgtc catcctagac 2058 atgcgcagag accacgagga gcagctgcag cggctaaagc tgctgaagga ccgagaggtc 2118 gatgcggcca ccagtgccac ctcccacacg cggtccctga atagcatcat ccaccagatg 2178 gagaagttct ccagcagcct gcacgagttg tcctcccgcg tggaggcctc gcacctcacc 2238 acctcccagg agcgggagct ggggatccgg cagcgtgacg agcagctgcg gggagcggct 2298 gggccagcag cagcgggaca tggaggagga gcggagccgg caacaggagg tcatcgggaa 2358 gatggaggca cggctgaatg agcagagccg gctgctggag caggaacgct ggcgggtgac 2418 tgccgagcag tccaaggcgg agtccatgca gcgcgcccta gaggagcaaa ggaaggtcac 2478 ggcccagcag atggccatgg aaagggcgga gctggaacgg gccaagagcg ccttgctgga 2538 ggagcagaag tctgtcatgc tcaagtgcgg ggaggagcgg cggcgcctgg ctgccgagtg 2598 ggcggagttc tccgcgcagc aaaagctgag agcaggctga gctgaagatc agggccagcg 2658 agctccgggc cgaggagaag cagctggcag cggagagagc agccctggag caggagcggc 2718 aggagctgcg gctggagaag gagaggatca acgccaccgc cctgcgtgtc aagctccgcg 2778 ccgaggaggt ggagagcatg agcaaggtgg cctccgagaa gtacgaggag ggggagcggg 2838 cattgcgcga ggcccagcag gtgcaggcag agcagcaggc ccggttgcag gcggtgcagc 2898 aacagcagga gcggctgcgg aagcaggagc agcacatgca ccaggagcat ctgagtctgg 2958 cccagcagag gctgcaactg gaccgcgcac gacaggacct gccctctagc ctcgtgggtc 3018 tgttccccag ggcccagggc cctgcagcct ccagccagag tgccctcatg cctcctgctc 3078 ccaccacccg ttggtgcagc cagccgccaa ctggcctgga ccccagcccc ttgcacctcc 3138 atgccaggct ggcactgctg aggcacatgg cagagcagca cctgcggtct gcggtggcac 3198 ctggcagctg gaccacagcc aggagaaggg tactattagc cctgcttcaa acatgcagaa 3258 actgaggccc ggggagatta aataacctgc ctgaaatgac accgtcctgg gccgccggac 3318 acccccgctg gggccgatgc ccaacagtga catcgacttg agcaacctgg agcggctgga 3378 gaagtaccgg agcttcgacc gctaccggcg ccgggcagag caggaggcgc aggccccgca 3438 ctggtggcgg acctaccgag agtatttcgg ggagaagaca gatcccaaag agaagattga 3498 tattgggctg cctccaccca aagtctcccg gacccaacag ctactggaac ggaaacaggc 3558 catccaggag cttcgggcca atgtggaaga ggagcgggct gcccgcctcc gcacagtgtc 3618 ccgctggatg ccgtgcgggc cgagtgggag aggacctgtg gcccctacca caagcagcgt 3678 ctggctgagt attacggcct ctaccgagac ctgttccacg gtgccacctt tgtgccccga 3738 gtccccctgc acgtggccta cgctgtgggt gaggatgacc tgatgcctgt gtactgtggc 3798 aatgaggtga ctccaaccga ggctgcccaa gcgccagagg tgacctatga ggcagaagag 3858 ggctccttgt ggacgttgct actcactagc ttggatgggc acctgctgga gccagatgct 3918 gagtacctcc actggctgct aaccaacatc ccgggtaacc gggtggctga aggacaggtg 3978 acgtgtccct acctcccccc cttccctgcc cgaggctccg gcatccaccg tcttgccttc 4038 ctgctcttca agcaggacca gccgattgac ttctctgagg acgcacgccc ctcaccctgc 4098 tatcagctgg cccagcggac cttccgcact tttgatttct acaagaaaca ccaagaaacc 4158 atgactccag ccggcttgtc cttcttccag tgccgctggg atgactccgt cacctacatc 4218 ttccaccagc ttctggacat gcgggagccg gtgtttgagt tcgtgcggcc gc 4270 <210> 22 <211> 4325 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (87)..(452) <400> 22 ggaaaaaaga aaagaaaaca tttttcctaa tgtaacaatg cgaatgctag aaaatgacaa 60 gactgatcgg ttttaaacca ttctga aga ctg act gag cgt gga agt tgc tca 113 Arg Leu Thr Glu Arg Gly Ser Cys Ser 1 5 aca aaa aaa gga acg ggt ata ttg aca gag tct tgc tct att gcc cag 161 Thr Lys Lys Gly Thr Gly Ile Leu Thr Glu Ser Cys Ser Ile Ala Gln 10 15 20 25 gct gca act ggt gtg atc tcg gct cac tac aac ctc tgc ctc ctg ggt 209 Ala Ala Thr Gly Val Ile Ser Ala His Tyr Asn Leu Cys Leu Leu Gly 30 35 40 tca agc gat tct cct gcc tca agc tcc caa gta gct ggg att aca agc 257 Ser Ser Asp Ser Pro Ala Ser Ser Ser Gln Val Ala Gly Ile Thr Ser 45 50 55 atg cac cac cat gcc tgg cta att ttt gta ttt tta gtg gag acg ggg 305 Met His His His Ala Trp Leu Ile Phe Val Phe Leu Val Glu Thr Gly 60 65 70 ttt cgc cac att ggc cag ggt ggt ctt gaa ctc ctg acc tca agt gat 353 Phe Arg His Ile Gly Gln Gly Gly Leu Glu Leu Leu Thr Ser Ser Asp 75 80 85 cca cct gcc ttg gcc tcc caa agt gct ggg att ata agc atg agc cac 401 Pro Pro Ala Leu Ala Ser Gln Ser Ala Gly Ile Ile Ser Met Ser His 90 95 100 105 tgc acc cag cct tat act gaa ctt tca atg ggt tca att cca cta gga 449 Cys Thr Gln Pro Tyr Thr Glu Leu Ser Met Gly Ser Ile Pro Leu Gly 110 115 120 gca taaaggccac tgcatatgag ttgtggaaag aagagattag aagaaggaag 502 Ala aacttgagat gagttcctcc cttcaacatt ctgtctcctc ctacctagca tcttctttct 562 tttagtcttt ctagaatgtc catctgtttt tggccattgc ggagagagaa gctgagcttt 622 aaaggagtag gagcttcaaa ggcttgctga gacaaaggaa aacccactcc cttggaggag 682 catgaccttt tcctgtaatt cttcctactg ctgttgttga gctccttgga tcctggctcc 742 tggacaccat catcaagaag actttatgga tgggctgtcc acccactgag agaagaggag 802 catcagctac agtttctctc tagattgcct tcttcatttt gagtaatgac tgtcagcagg 862 gtcagattaa acacaaaaca actggacaat tgcttggagg actaaactat aagggcacta 922 acatgtcaat agtaggctaa cacatccatg gaaaatatat ttaccagctc ttctctcagg 982 gaggattctg tgtggggttg gaagtaatga tttgttaaat tccttagggg tagaaagtag 1042 ggcataatca gaatatagag gaatatgctg tttgacttca gggtttctgt ttttcttact 1102 aggatatata aaacagggac tctagctaga ttgtttatga ccacagaggg taggctgagt 1162 gctcccatga tcttcctgct tggttcttgc ccatacagag gtcagccttt cctctaataa 1222 agattgaaca agtagtggtc tgagggagac accaattcat taccctacat gtctcttctc 1282 tgcactccag ggctttgata ataaagacac tggcagacta tctatcttcc atttctataa 1342 tgtgagccct tagggagtct tcgttcactt gggggtgagg gtcattgctc acagagtagt 1402 tcaagtcaaa tggaacttga actctttgcc tatgggcctg gtggtcagac tctgtgttga 1462 gttcattaga ttattggaga cacaaggtag agctggatgc ttcaaaaata tttggctaaa 1522 ggatgacatt gctggttatt tgtagataaa gccatgatgg aacctgcttg gaatcatgaa 1582 atatggaact ggtggtcatg tttaaaaata caactaatag ttaagtacct actggacact 1642 gtagagactt aggggctaga cagacatggt tcctgccccc ttggagctta cactgtagct 1702 tccccttagg tatgaagaac agtggctaca actaacaaat ggccacaaag atataattga 1762 gccagtgttc caattattag ggtaattcct atttccttaa tcattcctat tgaccatgtt 1822 ctataagcct gcattctata aatggcgtat gaccatgggc tgtttccccc cagcaagttg 1882 tacaaagttc tgtggtacca gggaaagggc ttaaggttag cagggcctct gcggaaggac 1942 atatgaagtg acttgggtta ggaaacagga agggatagga ttcaagaaca gctattgctt 2002 ctgttctata taggaaactg cagcgtgaaa aatgctgggc tgggaatttt gagacctggg 2062 ttttagtttg tgttctaata ctaacaagct atgtgactgt gggtaagtca tttcacattc 2122 catttggatg cctcttgagt gactccaggc ctctccagct ctaaaacatt aagatcaggc 2182 cctacgctac agctggccag tgtgtaattc ttctgtttct atgctgttag gtcaaataga 2242 tcttcaatag ttacttgatt gttattactt ttttctgaag tgggtgtttt atcaatgttt 2302 taggatacag tgagtctgct tctccccttt ggagttagga aggttgtagg aatatacact 2362 gtagagcata tgggagcttt atcccctcct tttttccctg ctacctttct ccctctcctt 2422 cccttcatca catttctatt gagcatatgc cattgccgtg taccaggtgt gtgctaggtt 2482 tggagataca aggtaaacct gagactttcc cagtctccag gagacaaaac cctaatttct 2542 ttcatctgct gtctttctct ttggaaagaa tcaacgatat cccaggggaa tgtgcccatg 2602 tcccagggta accaactaca gacagatgcc ccattctact caagcaactt ttagagtgcc 2662 ttgagataca catcagataa ttatgcaggg ccaggcatgg tgctgcacac ttgtaatcac 2722 agcactttgg caggccgagg cagcagattg cttgagccca ggaattcaag tgtagcctag 2782 ggaacatggc aaaaccccag ctctacaaaa aaatacacaa attagctgcg tgtggtggcc 2842 tatgacagga ggctgagatg ggaggattgc ttgagcctgt gaggtcgagg ctgcagtgag 2902 ccgagatcat gccattactc cagcctgggt gacataggga gaccctgtct tgaaaaaaaa 2962 aaaaaaaaga taattattca gccctagagt cattgtgaaa agatctatct tcagatataa 3022 ggaagaaaca atcttttatt tcttaggata aatctgtaga aggacctcca gacagtgaag 3082 gccactgact actttatact ctgtaagcca tccctccctg gtaggaagga ctatttccaa 3142 tcttacagag tacctctcag caaatagacg ttttcacata tactgtgatt catacatccc 3202 tatggctggt gacctcttta aaaaggaaag gaaaaagcct aatcaaacaa aaagatgctg 3262 ctagtaattc ttaccctatt gtgaatccta tataagcaaa tttgtatctt tgttttttcc 3322 tacattagca gatctatttg atatatctct gagtgcagaa aatattttat ggaaaaatca 3382 atatatggaa tttcaaattc agaattgctg atacacacta tttggtttca caattttatc 3442 ctaggaaata gtattagaga tttcaatttc tggcttaaat ggtagaatta attactctta 3502 actcttaatt ttacttctga gttgaggtca aggaacaggc agacacctgc agttaacgtc 3562 tatacctctc catggccaag agttttaatt ttctcgtctt caattttgta gatgttcatc 3622 attactaaat ggattgatta gtattttatc tcctctcctt gtccttactt tccctctggt 3682 aaatatgtta taaacagtgt aaggctccta agatagagta gctggtagga cttagaagag 3742 aaacaaaggg cactgataac tcacataaat ggaaaattgg ctctggaata actgacaaca 3802 tattcaagta ttttagtgca gtgtcactct cattaagaag aagagaatca gtaaatctat 3862 gtgactctaa acattctaat gaaaaaagga atattctgcc aattatctca catttctaaa 3922 tatctggata ttggccattg taaagacaaa acatacagat gatggacttg tctttccacc 3982 tctcatttgc atggtttgga gcattgtacc tccagccata gactctaagg caatttatat 4042 ttgcttcctc ttccctcttg agagaaaacg aaaatcttat ttttccaagc aattaaaact 4102 cttctgcttc agctaggatg aaagaattag gagttctgtc tccttgtatc taattgcatg 4162 tttcatcttt cttgttttaa tgattgacag aaaactaata aactgagaca tctttgaatc 4222 caggttgaat gtactctctt ggtggcccca ttgctaattt gtttgactat tttgcaggat 4282 ttcttactct gtaatggaaa ggtttattaa atatgagggg tgc 4325 <210> 23 <211> 4066 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1312)..(2451) <400> 23 ggcgaccgtg gggaggtgcc gccggggtcg caggtgagcg gttctatgct ggaggaggcg 60 gccagggaag cggcggctcc gtgaccagtg ggtgccctcg cagtgggtag ggtcccggag 120 gggtcagcgg caattggcgc aacgcttgct gccgggtttg gtccaagggc tgcgacgtag 180 cgggactgca cgctcgggag aagtgccacg cgcgtctgtc gcctgaccgg ggaggctggg 240 gagggcccag gccacggaaa caagactgca gaagtttctg ggcactcagt cgggactctc 300 atttaatacc cagagagagg agatcttcca ggttgccccg actcccaccg ggactcctac 360 cagcagcaac ctcatcattg tggccgaggc aggtgcgcgc ccctgctccc ctgggtggcc 420 ttccgggagc ccagtctaac tcgattcttc ccaggggctc tttttggacg gtcccaaagg 480 aggcagcggg agggaggtga aagatacttt gataaccgtc gacccataag tatacttgtt 540 atgcacctac cacgagtttt agagaagaac atactttttg gcagggaagt gaatccccta 600 taagaatata ggggagggga aagccacact ttaaagagaa tttgggtagg gtttgatatt 660 gtagatttgt gatgcttttc ttcttgaact gcttaactaa tttaccctca aatttttttg 720 atccggaact tgccgtctgg tttttctcag acttcttaat tctgacttat catgaagtat 780 ctaggaactt cattctcaag tttcagtgct tgtaaaaagt tgcctggtta tattatgcca 840 ttggcagtac atcatcttca caaggattac gtaagtgaac tacatctcat tcctgtttcc 900 aactagtgaa gaacgattgt gaaatgggat tttagaaaat ggctgttctc tgtgactggg 960 catagaaggt ttgtaagttt tagagactgc agctgttgaa tcctttctgc taagagagcg 1020 atgacaggca atagaaaagg gatagtgttt gacatctaaa atgacatatt ttcacatttt 1080 atgaggtgtt atatccccag caccaaaaat agtgcctttc acacagtagg agctcagtaa 1140 gtattttttg aggaaattat tggggaatga atggatggta gaaaacccaa gcttctgtta 1200 cttggatacc ggcatataaa ggagaggaca ggaagacaaa catttctgga aatggctttt 1260 atccaggaat tatccagact gccttgccac tagatgaatg gaagacaatg a ttt gaa 1317 Phe Glu 1 cta agg gcc agc aaa gaa tta tcc ctg gtt ttt gtg ctt tgc agc att 1365 Leu Arg Ala Ser Lys Glu Leu Ser Leu Val Phe Val Leu Cys Ser Ile 5 10 15 cct caa att gtt ttc aca tct ctt acc ata aaa act gca ttg aaa ttg 1413 Pro Gln Ile Val Phe Thr Ser Leu Thr Ile Lys Thr Ala Leu Lys Leu 20 25 30 aaa atg aag cag ttg aaa aga aaa agg aaa agc aat ttt agt gtt caa 1461 Lys Met Lys Gln Leu Lys Arg Lys Arg Lys Ser Asn Phe Ser Val Gln 35 40 45 50 gaa act cag acc ctt ttg aaa gaa att acg aaa agg aaa gaa gtc att 1509 Glu Thr Gln Thr Leu Leu Lys Glu Ile Thr Lys Arg Lys Glu Val Ile 55 60 65 ttt tcc aag cag ctc aat aca aca att aat gtg atg aag cga atg gct 1557 Phe Ser Lys Gln Leu Asn Thr Thr Ile Asn Val Met Lys Arg Met Ala 70 75 80 tgg gaa gag att gca cag tgt gtg aat gct gta gga gaa gga gaa cag 1605 Trp Glu Glu Ile Ala Gln Cys Val Asn Ala Val Gly Glu Gly Glu Gln 85 90 95 agg aca ggg acg gag gtg aaa aga agg tac ctt gac tgg cga gca ctt 1653 Arg Thr Gly Thr Glu Val Lys Arg Arg Tyr Leu Asp Trp Arg Ala Leu 100 105 110 atg aag aga aag agg atg aag gcc aac att aag ctg gtt ggt tca gga 1701 Met Lys Arg Lys Arg Met Lys Ala Asn Ile Lys Leu Val Gly Ser Gly 115 120 125 130 ttt ccc ctt ccc tcc tct gat ttg gat gac tct ctc act gaa gag ata 1749 Phe Pro Leu Pro Ser Ser Asp Leu Asp Asp Ser Leu Thr Glu Glu Ile 135 140 145 gat gaa aag att gga ttc cga aat gat gca aat ttt gac tgg caa aat 1797 Asp Glu Lys Ile Gly Phe Arg Asn Asp Ala Asn Phe Asp Trp Gln Asn 150 155 160 gtg gca gat ttc agg gat gca ggt gga tcc tta act gag gtc aag gtg 1845 Val Ala Asp Phe Arg Asp Ala Gly Gly Ser Leu Thr Glu Val Lys Val 165 170 175 gaa gag gaa gaa agg gat ccg cag agt cct gaa ttt gaa att gag gag 1893 Glu Glu Glu Glu Arg Asp Pro Gln Ser Pro Glu Phe Glu Ile Glu Glu 180 185 190 gag gaa gaa atg ttg tca tcc gtc ata cca gat tcc agg aga gaa aat 1941 Glu Glu Glu Met Leu Ser Ser Val Ile Pro Asp Ser Arg Arg Glu Asn 195 200 205 210 gaa ctt ccc gat ttc ccc cac att gat gag ttt ttt acc ctt aac tca 1989 Glu Leu Pro Asp Phe Pro His Ile Asp Glu Phe Phe Thr Leu Asn Ser 215 220 225 aca cca tct aga tct gca tat gat gag cct cat ttg ctc gta aat att 2037 Thr Pro Ser Arg Ser Ala Tyr Asp Glu Pro His Leu Leu Val Asn Ile 230 235 240 gag aaa cag aaa cta gag ttg gaa aaa cga cga ctg gat atc gag gcc 2085 Glu Lys Gln Lys Leu Glu Leu Glu Lys Arg Arg Leu Asp Ile Glu Ala 245 250 255 gaa agg ctg cag gta gaa aag gaa cgc cta caa atc gag aaa gag agg 2133 Glu Arg Leu Gln Val Glu Lys Glu Arg Leu Gln Ile Glu Lys Glu Arg 260 265 270 ctg cgg cat tta gac atg gaa cat gag cgg ctt cag cta gag aag gag 2181 Leu Arg His Leu Asp Met Glu His Glu Arg Leu Gln Leu Glu Lys Glu 275 280 285 290 cgg ctg cag att gaa aga gaa aag ttg agg tta cag ata gtc aat tca 2229 Arg Leu Gln Ile Glu Arg Glu Lys Leu Arg Leu Gln Ile Val Asn Ser 295 300 305 gag aaa ccg tcc ttg gaa aat gaa ctt ggt caa gga gaa aaa tcc atg 2277 Glu Lys Pro Ser Leu Glu Asn Glu Leu Gly Gln Gly Glu Lys Ser Met 310 315 320 ctt caa cca cag gac ata gaa aca gag aag tta aaa ctt gag cga gaa 2325 Leu Gln Pro Gln Asp Ile Glu Thr Glu Lys Leu Lys Leu Glu Arg Glu 325 330 335 cgc ttg caa ctg gaa aag gat agg ctg cag ttt ttg aag ttt gaa tct 2373 Arg Leu Gln Leu Glu Lys Asp Arg Leu Gln Phe Leu Lys Phe Glu Ser 340 345 350 gag aag ctg cag att gaa aag gaa cgc tta cag gta gag aaa gac aga 2421 Glu Lys Leu Gln Ile Glu Lys Glu Arg Leu Gln Val Glu Lys Asp Arg 355 360 365 370 ctt cga att cag aaa gaa gga cac ttg cag tgatttttcc aggcttccat 2471 Leu Arg Ile Gln Lys Glu Gly His Leu Gln 375 380 ttagcaaatg tttgaaaact ctagattttt ctcatatcag gtgatataat gatggttgct 2531 ggattagctg tggtttcttg tctaatgtca gtgttcagta ggaaaaagtt atatgtggat 2591 aactgtatgc ctaagtagta tataaaagct gtgccctagc gtaaacagta tagcagaaac 2651 ttactgtgct ggactcttta ccttataata ttacatagag tcttgtattg tctgtgtacc 2711 cagagtttac aattatgtcc atataaaatt ctagcccaga agttctcatc tggggtagat 2771 tttggccttc agaagaccaa tttggtgatg tctggagaca tgttgggttg tcaaaactgg 2831 ggtggggaaa aggttgctac tgtgcaatgc atacctcctc aacacccccc cacactcagt 2891 aaagaatttt ccaacccaaa atatcattag tcctgaggtt gagaaaccct gtcctagcct 2951 aactgtgtac ctctatagct atgttttata gttttagaat attaaaacct cagatattta 3011 tgtgggtagg tacttaaatg gccaaaaact ttaactatga aatgttactg tgtagtatat 3071 tgaatatagg aagtgatgaa gattataggt attttattcc catgtttcca tctataaata 3131 gccttctcag attcagaaaa caatacagag aacatcagaa attttctaaa atgggtcact 3191 ttgaaaagaa ttctttttct cactattaat gctttagaag caagacgcaa ttttaaagct 3251 ttagttcctt ttctttcagt cattgtctta gtttgggtac aaaaatgtca tttcagtaat 3311 gtactgaaat cttataagtg aatagttgaa gctagtaaaa atgataccag tataaaaatg 3371 gtacttgtag tccatgagct tgaacccaat gactgattgt ttgactttta aaataagtaa 3431 tagcagccat ttgggagtag ggggtaggtg gggaagatgt actccgtatc aaataataat 3491 gatgttgaaa taatgatagt aggtatgtat tatggattgg agaagcactt attacactat 3551 ctaacctaat atgtagaaca attcttgaga gttgtatctg tcgttatttc tgaatgtgaa 3611 gctcagagaa gtgacacaga gtaaatggct gatcttctat attgtagtat attttgtcct 3671 tccctcttcc ctgaggaaca aagcacgtat ctttagtctc tttgatattt attctgagac 3731 caagggcttg cttgacctga tgattttcct tcagctctct gaaggtgctt tttccacaat 3791 ccaagtgatt ctgatacaca ctaaagttga gaatcactgc actagatcac tttgtgtttt 3851 ctgattttca aggttgatac gtagctttaa tacagctctt ctgttgacag ttattacttt 3911 aattttgcat ttgttccttg taagaatggc tggaaactgt gtgttgacat ttgaggatgg 3971 gtatgcaagg aaaaaatata cttctgttta cttactctga ctttgaaata gtgttatttt 4031 tctatatctg aaataaatgc ttctaccata gaaat 4066 <210> 24 <211> 4315 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (53)..(1183) <400> 24 cattggcgct tctctcctgc agtccgcctc tgggccctgc cgcatttctt ga gac tta 58 Asp Leu 1 aag tgg cat tct aaa ggc aat tta aaa atc atg tca agc tca gtt gaa 106 Lys Trp His Ser Lys Gly Asn Leu Lys Ile Met Ser Ser Ser Val Glu 5 10 15 cag aaa aaa ggg cct aca aga cag cgc aaa tgt ggc ttt tgt aag tca 154 Gln Lys Lys Gly Pro Thr Arg Gln Arg Lys Cys Gly Phe Cys Lys Ser 20 25 30 aat aga gac aag gaa tgt gga cag tta cta ata tct gaa aac cag aag 202 Asn Arg Asp Lys Glu Cys Gly Gln Leu Leu Ile Ser Glu Asn Gln Lys 35 40 45 50 gtg gca gcg cac cat aag tgc atg ctc ttt tca tct gct ttg gta tca 250 Val Ala Ala His His Lys Cys Met Leu Phe Ser Ser Ala Leu Val Ser 55 60 65 tca cac tct gat aat gaa agt ctt ggt gga ttt tct att gaa gat gtc 298 Ser His Ser Asp Asn Glu Ser Leu Gly Gly Phe Ser Ile Glu Asp Val 70 75 80 caa aag gaa att aaa aga ggc acg aag ctg atg tgt tct ttg tgc cat 346 Gln Lys Glu Ile Lys Arg Gly Thr Lys Leu Met Cys Ser Leu Cys His 85 90 95 tgt cct gga gca aca att ggt tgt gat gtg aaa aca tgt cac agg aca 394 Cys Pro Gly Ala Thr Ile Gly Cys Asp Val Lys Thr Cys His Arg Thr 100 105 110 tac cac tac cac tgt gca ttg cat gat aaa gct caa ata cga gag aaa 442 Tyr His Tyr His Cys Ala Leu His Asp Lys Ala Gln Ile Arg Glu Lys 115 120 125 130 cct tca caa gga att tac atg gtc tat tgc cga aaa cac aag aaa act 490 Pro Ser Gln Gly Ile Tyr Met Val Tyr Cys Arg Lys His Lys Lys Thr 135 140 145 gca cat aac tcc gaa gct gat tta gaa gaa agt ttt aat gaa cat gaa 538 Ala His Asn Ser Glu Ala Asp Leu Glu Glu Ser Phe Asn Glu His Glu 150 155 160 ctg gag ccc tca tca cct aaa agt aaa aag aaa agt cgc aaa gga agg 586 Leu Glu Pro Ser Ser Pro Lys Ser Lys Lys Lys Ser Arg Lys Gly Arg 165 170 175 cca aga aaa act aat ttt aaa ggg ctg tca gaa gat acc agg tcc aca 634 Pro Arg Lys Thr Asn Phe Lys Gly Leu Ser Glu Asp Thr Arg Ser Thr 180 185 190 tcc tcc cat gga aca gat gaa atg gaa agt agt tcc tat aga gat agg 682 Ser Ser His Gly Thr Asp Glu Met Glu Ser Ser Ser Tyr Arg Asp Arg 195 200 205 210 tct cca cac aga agc agc cct agt gac acc agg cct aaa tgt gga ttt 730 Ser Pro His Arg Ser Ser Pro Ser Asp Thr Arg Pro Lys Cys Gly Phe 215 220 225 tgc cat gta ggg gag gaa gaa aat gaa gca cga gga aaa ctg cat ata 778 Cys His Val Gly Glu Glu Glu Asn Glu Ala Arg Gly Lys Leu His Ile 230 235 240 ttt aat gcc aag aag gca gct gcc cat tat aag tgc atg ttg ttt tct 826 Phe Asn Ala Lys Lys Ala Ala Ala His Tyr Lys Cys Met Leu Phe Ser 245 250 255 tct ggc aca gtc cag ctc aca aca aca tca aga gca gaa ttt gga gac 874 Ser Gly Thr Val Gln Leu Thr Thr Thr Ser Arg Ala Glu Phe Gly Asp 260 265 270 ttt gat att aaa act gta ctt cag gag att aaa cga gga aaa aga atg 922 Phe Asp Ile Lys Thr Val Leu Gln Glu Ile Lys Arg Gly Lys Arg Met 275 280 285 290 aaa tgt aca ctt tgc agt cag cct ggt gct act att gga tgt gaa ata 970 Lys Cys Thr Leu Cys Ser Gln Pro Gly Ala Thr Ile Gly Cys Glu Ile 295 300 305 aaa gcc tgt gtt aag act tac cat tac cac tgt gga gta caa gac aaa 1018 Lys Ala Cys Val Lys Thr Tyr His Tyr His Cys Gly Val Gln Asp Lys 310 315 320 gct aaa tac att gaa aat atg tca cga gga att tac aaa cta tac tgt 1066 Ala Lys Tyr Ile Glu Asn Met Ser Arg Gly Ile Tyr Lys Leu Tyr Cys 325 330 335 aaa aat cat agt gga aat gat gag aga gat gaa gaa gat gag gaa cga 1114 Lys Asn His Ser Gly Asn Asp Glu Arg Asp Glu Glu Asp Glu Glu Arg 340 345 350 gag agt aaa agc cga gga aaa gta gaa att gat cag caa caa cta act 1162 Glu Ser Lys Ser Arg Gly Lys Val Glu Ile Asp Gln Gln Gln Leu Thr 355 360 365 370 cag cag caa ctt aat gga aac taggttcatg ggacagagtt agaaaactgg 1213 Gln Gln Gln Leu Asn Gly Asn 375 gaatgaataa gacatccata actactattc ttttttcact gttttctaaa atcaaaaagg 1273 gtttgtaact ttttactgcc caactcttag atccttcatt gaactgccta aaaatgtctt 1333 gtttgtttta tgagccctca ctagaaggct gagtttgaca tgttgatatt acgtagctat 1393 agtttgcagt ttctgggaag caattgaaac actattaacc ctgtgtatag tgtcaacagt 1453 taaagcagac gaaacgaagt aagctatatt tctggactga acaaagctct gctgtttaga 1513 gcatttaagt ttgtttagtg gatccatact caaaggaaag cataagcaaa ttttccttta 1573 caatgcaaac atgccactgg tggcagcaca tggtaatttg tggatttttt tttcatactc 1633 aagtaatgga ggctagaaat gaagagaacc ttctttttct cttgactttg acagcacatg 1693 ctaaaaatct cttccaagaa gtatgctaaa gcttttcatt tggttcctgt taaagttgtt 1753 ctcactgacc agcatggact caggcaactg gtaatgataa gctatgagct ccagtgcttt 1813 tgccaaaatt ctcttgacag cacacctcct ctctttccat gttatacaaa ggacttctgg 1873 caaaatgatt gagtccttca agtttaaact aacatttggc aacagcaaat taaacgtttt 1933 taagatgtaa agaaagggtt accgcttgct aaggacttca gacaccatgt ccgaaacctg 1993 ttcctctcaa gtgccctgtt gtgtggaaca cttcacatat tggcgcacag tacgtaagga 2053 ggtctcatgt gctgtaggag taaaaaagtc tttgcataaa acagtattta tttttacttt 2113 tgtgaccact attttagaaa ctttatttaa tattttaatg ttttcagtca ttgctttggt 2173 tatctataaa ataggctttt gtgccctact tttcttcttg tagggcttgg tggtgtttta 2233 tcgattgtca gaattgtttt tgaaagccta agaacccagc tttttagaaa ggattttcac 2293 actggcattt ctaggtagtg atattttctt ccacttacct gctgaagcac atttatgcat 2353 ttctttatgg caaaaccaaa taactttagt tgtggtctgc ctgatactac catagcacct 2413 cagtaccaag gggagggatt ttgactagtt gaattattaa gccaccacaa taaagcagat 2473 ttttaaataa gatataataa tgttaacttg actgtacatt gagatattct gcagctgata 2533 gagcagcatt ttaaaaatgt aacaggtgga aaattacact gtgcttaatg actgattttt 2593 ttttaaactg cgagtccctt aagatcacgt ttgtcaagtg tgtattcaca catttactta 2653 aatcaaggga ctcaatgctt gcttttattt taaccatctt ttactatttt tagaaggaaa 2713 ctagctttag tagtgggttg ccctgtatgt tttctctttt tgctcttaat atgccattgg 2773 gtttttgtgt gtatgtgatt ttcaaaattc atgacttgaa gtgcaaggac agatctagat 2833 gtttgtttac caagctatgt gacttctccc aaaggatctg tactttcttt ccttacaaca 2893 gcttgaaaat cattatttta aaatccttaa atcactgtgt ctagatcatt ttttacattg 2953 tgtgccatag acttacccat gggacaacag agctccttca tttttggaca actactgtaa 3013 tcattttttt tttaggaaaa atggaaggtg ccgggggtaa tcatggccag tcaataatta 3073 tataaaggag ttcaaatact atagctgtca gttgatgaat ttgttatgta gtaaaatgta 3133 tgactttgta tgggtttctt cagccctttt tctgccacta gcaaccagaa tagcacttta 3193 ccttttggtt ggctagataa gtggctgact acctgttttt ctcactgtgg tgtgattggc 3253 taaacaatct cgcattaaaa attcaaatgt aaattgaatt cacatgaaaa atcatgtttg 3313 gttgtaaacc tccaatgttt tgattctcta atcatgtttt cgtcacatgc tgagtaaaag 3373 tgccttacaa tgtaaaaatt gtacagtact tatgttccca agtagcatca tcatcttctg 3433 ggtagtaatt acattgtggt attaatattt agaaaaatgg acctcagcag tgtatttact 3493 gtacatctct taagtcctta actgtagttt taataagcat gacattattt gataagtata 3553 taacatttac atcatttcaa aaaatactgc cgttactgtc ttttatgcat attttagcct 3613 gaaattttga agcgtctttt ttctttcttt tttctttttt tgttttgttt tttgttattg 3673 atattaaaca gtgtaatctt tgcaagcgta tattgaagat tattctggag catttattgc 3733 cttaccagaa atgttagtag gaaatgttct ttagagtaga aagatagact tgagtttcta 3793 tacttttaag aagagctctt tgttcctggg ggaggggggc agggggtgaa ttttactttc 3853 atctcaagtt attaaaaacc cacaactgaa gtaaatttta tttcaagaat cagcagtttt 3913 agaatttcag atagtacttg ctcagaagta catgctactc aagatattaa gagataacaa 3973 gatctgtaga tctgctattg aatcagaatc tgtgtacttg aacaaatgtg tgaatctcaa 4033 atatctcaaa gcaaaagaaa aagtgttcta gagtgttgtt gcttttttaa aaaaagcgct 4093 gaagttagac caaggtatac agttttgttc taacagacat ttaggttaat tgtaaagata 4153 aggaatgcat tatgggtcaa aaatcaaaca ttcctctcat gttatgtata ttttgttcct 4213 gttatattgg ctttattttc aaaattgtag tttgtagtat tagtttcctt ttattggtat 4273 tcttgcatat actattcatt caataaatga cttatgactt tc 4315 <210> 25 <211> 3555 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (50)..(2512) <400> 25 tttattccta ctttattgca gcagtattga aagtttttaa agaatataa ccg tgt gtg 58 Pro Cys Val 1 ttg gta aca gac aga aga atg gaa gca ttc cag gaa ctt cgt aaa cca 106 Leu Val Thr Asp Arg Arg Met Glu Ala Phe Gln Glu Leu Arg Lys Pro 5 10 15 tca gca cgt ttg gag tgt gac cat tgc agt ttc aga ggc aca gac tat 154 Ser Ala Arg Leu Glu Cys Asp His Cys Ser Phe Arg Gly Thr Asp Tyr 20 25 30 35 gaa aat gta caa atc cat atg ggt acc atc cat cca gaa ttt tgt gat 202 Glu Asn Val Gln Ile His Met Gly Thr Ile His Pro Glu Phe Cys Asp 40 45 50 gaa atg gat gct ggt ggg cta ggc aaa atg ata ttt tac cag aaa agt 250 Glu Met Asp Ala Gly Gly Leu Gly Lys Met Ile Phe Tyr Gln Lys Ser 55 60 65 gca aag tta ttt cac tgc cat aaa tgc ttc ttc acc agc aag atg tac 298 Ala Lys Leu Phe His Cys His Lys Cys Phe Phe Thr Ser Lys Met Tyr 70 75 80 tct aat gta tac tat cac atc aca tcc aaa cat gca tcc cca gac aaa 346 Ser Asn Val Tyr Tyr His Ile Thr Ser Lys His Ala Ser Pro Asp Lys 85 90 95 tgg aat gat aaa cca aaa aat cag ttg aac aaa gaa aca gat cct gtg 394 Trp Asn Asp Lys Pro Lys Asn Gln Leu Asn Lys Glu Thr Asp Pro Val 100 105 110 115 aaa agc cct cct ctt cct gaa cac cag aaa ata ccc tgc aat tca gca 442 Lys Ser Pro Pro Leu Pro Glu His Gln Lys Ile Pro Cys Asn Ser Ala 120 125 130 gaa cca aaa tcc ata cct gcc ctt tca atg gaa aca cag aaa ctt ggt 490 Glu Pro Lys Ser Ile Pro Ala Leu Ser Met Glu Thr Gln Lys Leu Gly 135 140 145 tca gtt ttg tct cca gaa tcg cca aaa cct act cct ctt act ccc ctg 538 Ser Val Leu Ser Pro Glu Ser Pro Lys Pro Thr Pro Leu Thr Pro Leu 150 155 160 gag cct cag aaa cct ggc tct gtt gtt tct cct gag cta cag aca cct 586 Glu Pro Gln Lys Pro Gly Ser Val Val Ser Pro Glu Leu Gln Thr Pro 165 170 175 ctt cct tct cct gag cct tca aaa cct gcc tct gtt tct tct cct gaa 634 Leu Pro Ser Pro Glu Pro Ser Lys Pro Ala Ser Val Ser Ser Pro Glu 180 185 190 195 cct cca aaa tca gtc cct gtt tgt gag tct cag aaa ctt gcc cct gtt 682 Pro Pro Lys Ser Val Pro Val Cys Glu Ser Gln Lys Leu Ala Pro Val 200 205 210 cct tct cca gaa cca cag aaa cct gcc cct gta tct cct gag tca gta 730 Pro Ser Pro Glu Pro Gln Lys Pro Ala Pro Val Ser Pro Glu Ser Val 215 220 225 aag gct act ctt agt aat ccc aaa ccc cag aag cag tct cat ttc ccg 778 Lys Ala Thr Leu Ser Asn Pro Lys Pro Gln Lys Gln Ser His Phe Pro 230 235 240 gaa aca ttg ggg cca cct tca gcc tca tct cca gag tca cca gtt cta 826 Glu Thr Leu Gly Pro Pro Ser Ala Ser Ser Pro Glu Ser Pro Val Leu 245 250 255 gct gct tcc cca gaa cct tgg gga cca tcc cca gct gca tct cca gaa 874 Ala Ala Ser Pro Glu Pro Trp Gly Pro Ser Pro Ala Ala Ser Pro Glu 260 265 270 275 tct cgg aag tca gcc cgg act acc tcc cct gag cca agg aag cca tcc 922 Ser Arg Lys Ser Ala Arg Thr Thr Ser Pro Glu Pro Arg Lys Pro Ser 280 285 290 cct tca gag tct cct gaa cct tgg aag ccg ttc cct gct gtc tcc cca 970 Pro Ser Glu Ser Pro Glu Pro Trp Lys Pro Phe Pro Ala Val Ser Pro 295 300 305 gag cct agg aga cca gcc ccc gct gtg tca cca ggc tct tgg aaa cca 1018 Glu Pro Arg Arg Pro Ala Pro Ala Val Ser Pro Gly Ser Trp Lys Pro 310 315 320 ggg cca cct ggg tcc cct agg cct tgg aaa tcc aat cct tca gca tca 1066 Gly Pro Pro Gly Ser Pro Arg Pro Trp Lys Ser Asn Pro Ser Ala Ser 325 330 335 tca gga cct tgg aag cca gct aaa cct gct cca tct gtg tct cct gga 1114 Ser Gly Pro Trp Lys Pro Ala Lys Pro Ala Pro Ser Val Ser Pro Gly 340 345 350 355 cct tgg aaa cca att cct tct gta tct cct gga cct tgg aaa cca act 1162 Pro Trp Lys Pro Ile Pro Ser Val Ser Pro Gly Pro Trp Lys Pro Thr 360 365 370 cca tct gtg tct tct gca tcc tgg aaa tct tca tca gtc tca ccc agc 1210 Pro Ser Val Ser Ser Ala Ser Trp Lys Ser Ser Ser Val Ser Pro Ser 375 380 385 tcc tgg aag tct ccc cct gca tct cct gag tca tgg aag tct ggc cca 1258 Ser Trp Lys Ser Pro Pro Ala Ser Pro Glu Ser Trp Lys Ser Gly Pro 390 395 400 cca gaa ctc cga aag aca gct ccc acg ttg tct cct gaa cat tgg aag 1306 Pro Glu Leu Arg Lys Thr Ala Pro Thr Leu Ser Pro Glu His Trp Lys 405 410 415 gca gtt ccc cca gtg tct cca gag ctt cgc aaa ccc ggc cca cca cta 1354 Ala Val Pro Pro Val Ser Pro Glu Leu Arg Lys Pro Gly Pro Pro Leu 420 425 430 435 tcc cca gag atc cgt agt cca gca gga tct cca gag ctc aga aaa ccc 1402 Ser Pro Glu Ile Arg Ser Pro Ala Gly Ser Pro Glu Leu Arg Lys Pro 440 445 450 tca ggg tca cca gat ctt tgg aag ctt tct cct gat cag cgg aaa act 1450 Ser Gly Ser Pro Asp Leu Trp Lys Leu Ser Pro Asp Gln Arg Lys Thr 455 460 465 tct cct gct tca ctt gat ttc cct gag tcc cag aaa agt tcc cgt ggt 1498 Ser Pro Ala Ser Leu Asp Phe Pro Glu Ser Gln Lys Ser Ser Arg Gly 470 475 480 ggt tct cct gat ctc tgg aag tct tcc ttt ttt att gag cct cag aaa 1546 Gly Ser Pro Asp Leu Trp Lys Ser Ser Phe Phe Ile Glu Pro Gln Lys 485 490 495 cct gtc ttc cct gag acc cga aaa cca ggt cct tct ggg cca tct gag 1594 Pro Val Phe Pro Glu Thr Arg Lys Pro Gly Pro Ser Gly Pro Ser Glu 500 505 510 515 tcc ccc aaa gca gcc tca gat atc tgg aag cct gtt ctc tct atc gat 1642 Ser Pro Lys Ala Ala Ser Asp Ile Trp Lys Pro Val Leu Ser Ile Asp 520 525 530 act gag cct aga aaa cct gcc ctg ttt ccc gag cct gcc aaa aca gcc 1690 Thr Glu Pro Arg Lys Pro Ala Leu Phe Pro Glu Pro Ala Lys Thr Ala 535 540 545 cct cct gct tct cca gaa gca cgc aaa cgt gcc ctt ttt cca gag ccc 1738 Pro Pro Ala Ser Pro Glu Ala Arg Lys Arg Ala Leu Phe Pro Glu Pro 550 555 560 cgg aag cat gcc ctt ttc cct gaa ctc ccc aaa tct gct cta ttc tca 1786 Arg Lys His Ala Leu Phe Pro Glu Leu Pro Lys Ser Ala Leu Phe Ser 565 570 575 gaa tca cag aag gct gtt gag ctt ggt gat gaa cta caa ata gat gcc 1834 Glu Ser Gln Lys Ala Val Glu Leu Gly Asp Glu Leu Gln Ile Asp Ala 580 585 590 595 ata gat gat caa aaa tgt gat att ttg gtt cag gaa gaa ctt cta gct 1882 Ile Asp Asp Gln Lys Cys Asp Ile Leu Val Gln Glu Glu Leu Leu Ala 600 605 610 tca cct aag aaa ctc tta gaa gat act tta ttt cct tcc tca aag aag 1930 Ser Pro Lys Lys Leu Leu Glu Asp Thr Leu Phe Pro Ser Ser Lys Lys 615 620 625 ctc aag aaa gac aac caa gag agc tca gac gct gag ctt agt agt agt 1978 Leu Lys Lys Asp Asn Gln Glu Ser Ser Asp Ala Glu Leu Ser Ser Ser 630 635 640 gag tac ata aaa aca gat ttg gat gcg atg gat att aag ggc cag gaa 2026 Glu Tyr Ile Lys Thr Asp Leu Asp Ala Met Asp Ile Lys Gly Gln Glu 645 650 655 tca agc agt gat caa gag cag gtt gat gtg gaa tcc att gat ttt agc 2074 Ser Ser Ser Asp Gln Glu Gln Val Asp Val Glu Ser Ile Asp Phe Ser 660 665 670 675 aaa gag aac aaa atg gac atg act agt cca gag cag tct aga aat gtg 2122 Lys Glu Asn Lys Met Asp Met Thr Ser Pro Glu Gln Ser Arg Asn Val 680 685 690 cta cag ttt act gaa gaa aaa gaa gct ttt atc tct gaa gag gag att 2170 Leu Gln Phe Thr Glu Glu Lys Glu Ala Phe Ile Ser Glu Glu Glu Ile 695 700 705 gca aaa tac atg aag cgt gga aaa gga aag tat tat tgc aaa att tgt 2218 Ala Lys Tyr Met Lys Arg Gly Lys Gly Lys Tyr Tyr Cys Lys Ile Cys 710 715 720 tgc tgt cgt gct atg aaa aaa ggt gct gtt ttg cat cat ttg gtt aat 2266 Cys Cys Arg Ala Met Lys Lys Gly Ala Val Leu His His Leu Val Asn 725 730 735 aag cat aat gtt cat agc cct tac aaa tgc aca atc tgt gga aag gct 2314 Lys His Asn Val His Ser Pro Tyr Lys Cys Thr Ile Cys Gly Lys Ala 740 745 750 755 ttt ctt ttg gaa tct ctc ctt aaa aat cat gta gca gcc cat ggg caa 2362 Phe Leu Leu Glu Ser Leu Leu Lys Asn His Val Ala Ala His Gly Gln 760 765 770 agt tta ctt aaa tgt cca cgt tgt aat ttt gaa tca aat ttc cca aga 2410 Ser Leu Leu Lys Cys Pro Arg Cys Asn Phe Glu Ser Asn Phe Pro Arg 775 780 785 ggt ttt aag aaa cat tta act cat tgt caa agc cgg cat aat gaa gag 2458 Gly Phe Lys Lys His Leu Thr His Cys Gln Ser Arg His Asn Glu Glu 790 795 800 gca aat aaa aag cta atg gaa gct ctt gaa ccg cca ctg gag gag cag 2506 Ala Asn Lys Lys Leu Met Glu Ala Leu Glu Pro Pro Leu Glu Glu Gln 805 810 815 caa att tgataacaca gtgtgaatat ttgttctaca aaggtgtttg ttggaaccat 2562 Gln Ile 820 tctttgtaag tatagcttat cagatagcat agttggatca gtagatgaca tgtatggtgt 2622 accgtgtttc actgtctcag ttgtgttact aagaatgagc atttgatcat ttttttctgg 2682 tctctgtcta tgtgactatc ttgtaagtca ataaatttct gtatagtcca gatggattaa 2742 acttctcatt tcttttaaat atgtatgaat aataatacaa ggaagtaggc attccattta 2802 ataatcaaga gcaagttgta ctcaaagcat tcagttaaag tgtatctgtg tgtggaacta 2862 atttcagaca atagaaaata ttagttgaaa tgtttaagaa ttaggcatga aaaataaatt 2922 tgagaaattt tgtttcctta catgtatttt taaatcataa gagttatttt ctatctgatg 2982 taaaattagt ttataaatct taatcagctt ctagatgttt attagctttt atgtcatgaa 3042 atgttggagt ctcagggttg ctgattttct gctaatggga aaaattgact aagtctttaa 3102 aatagtttgc agccttctcc cacaggagac aagtgaaaga taagtgtgat tttagatctt 3162 tcttgtccat agttgttttc agtggagtct tccattctgt atcttaccct aagatctggt 3222 tcttccctcc ccatccccac cccccaccca ccgcctgcca gctcacacta atagatgatt 3282 cttaattgcc aaatgtgtta gagtttgtat atcctactcc tgggccttac atgtcgcctg 3342 ttggggctta agaccaggtt gataagtagg aactgaaagt cttccagatt cacagtagaa 3402 aattttatag acatttctgt taaagaaata tatcgatttt atgtttttca attatgttac 3462 tgtaaatacc ttgtacctgt tcatggatta ttttattcta aaatattttg tcaaatgtgt 3522 atcaaccaaa ttaaaaagaa aggttttcat gtc 3555 <210> 26 <211> 4353 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(3898) <400> 26 g cag tgc tca tat acc tcc ccc tac ttc tat gca ctg agg aag cat atc 49 Gln Cys Ser Tyr Thr Ser Pro Tyr Phe Tyr Ala Leu Arg Lys His Ile 1 5 10 15 aag aaa gac cac ccc gcc ctg aaa gcc aca gtc acg tcc atc atg cga 97 Lys Lys Asp His Pro Ala Leu Lys Ala Thr Val Thr Ser Ile Met Arg 20 25 30 tgg gca ttt cta gat ggc ttg ata gaa gct ggc tac cac tgc gag tgg 145 Trp Ala Phe Leu Asp Gly Leu Ile Glu Ala Gly Tyr His Cys Glu Trp 35 40 45 tgc atc tac tcc cat acg gag ccc aac ggt ttg ctc ctg cat tac caa 193 Cys Ile Tyr Ser His Thr Glu Pro Asn Gly Leu Leu Leu His Tyr Gln 50 55 60 cgg agg cat cca gaa cac tat gtt gat tac acc tac atg gct act aaa 241 Arg Arg His Pro Glu His Tyr Val Asp Tyr Thr Tyr Met Ala Thr Lys 65 70 75 80 ctg tgg gct ggg cca gac cca tcc cct ccc tct ctc aca atg cca gcc 289 Leu Trp Ala Gly Pro Asp Pro Ser Pro Pro Ser Leu Thr Met Pro Ala 85 90 95 gaa gcc aaa acc tac aga tgc agg gac tgt gtt ttc gaa gct gtt tcc 337 Glu Ala Lys Thr Tyr Arg Cys Arg Asp Cys Val Phe Glu Ala Val Ser 100 105 110 atc tgg gac atc act aat cac tac caa gca ttc cac ccc tgg gcc atg 385 Ile Trp Asp Ile Thr Asn His Tyr Gln Ala Phe His Pro Trp Ala Met 115 120 125 aat ggt gat gag tca gtg cta ctg gac atc atc aag gag aaa gat gct 433 Asn Gly Asp Glu Ser Val Leu Leu Asp Ile Ile Lys Glu Lys Asp Ala 130 135 140 gtg gag aag ccc att ctt tca tcc gaa gag ttg gca ggc cct gtg aat 481 Val Glu Lys Pro Ile Leu Ser Ser Glu Glu Leu Ala Gly Pro Val Asn 145 150 155 160 tgt gaa aac agt ata ccc acc cct ttc ccg gag cag gaa gct gaa tgt 529 Cys Glu Asn Ser Ile Pro Thr Pro Phe Pro Glu Gln Glu Ala Glu Cys 165 170 175 cca gag gat gca aga ctg tcc cct gag aaa agc ctg cag cta gct tca 577 Pro Glu Asp Ala Arg Leu Ser Pro Glu Lys Ser Leu Gln Leu Ala Ser 180 185 190 gcc aac ccc gcc ata tcc tcc acc cca tac cag tgc acg gta tgc caa 625 Ala Asn Pro Ala Ile Ser Ser Thr Pro Tyr Gln Cys Thr Val Cys Gln 195 200 205 tct gag tat aac aac ttg cac ggc ctt ctc act cat tat ggg aag aag 673 Ser Glu Tyr Asn Asn Leu His Gly Leu Leu Thr His Tyr Gly Lys Lys 210 215 220 cac cct ggc atg aaa gtg aag gct gct gac ttt gcc cag gac att gac 721 His Pro Gly Met Lys Val Lys Ala Ala Asp Phe Ala Gln Asp Ile Asp 225 230 235 240 atc aac cca ggt gcc gtc tac aaa tgc agg cat tgc cca tac atc aac 769 Ile Asn Pro Gly Ala Val Tyr Lys Cys Arg His Cys Pro Tyr Ile Asn 245 250 255 acc cgc atc cac ggc gta ctg acc cac tac cag aag cga cac ccg tcc 817 Thr Arg Ile His Gly Val Leu Thr His Tyr Gln Lys Arg His Pro Ser 260 265 270 atc aag gtg acc gct gag gac ttt gtg cac gac gta gag cag tct gct 865 Ile Lys Val Thr Ala Glu Asp Phe Val His Asp Val Glu Gln Ser Ala 275 280 285 gac ata tcc cag aat gac gtg gag gag acg agc agg atc ttc aag caa 913 Asp Ile Ser Gln Asn Asp Val Glu Glu Thr Ser Arg Ile Phe Lys Gln 290 295 300 ggg tat ggc gcc tac cgg tgc aaa ctg tgt ccg tac aca cac ggc act 961 Gly Tyr Gly Ala Tyr Arg Cys Lys Leu Cys Pro Tyr Thr His Gly Thr 305 310 315 320 ttg gag aaa cta aaa atc cac tac gag aag tat cac aat cag cct gaa 1009 Leu Glu Lys Leu Lys Ile His Tyr Glu Lys Tyr His Asn Gln Pro Glu 325 330 335 ttt gat gtc ttt tcc cag tcg ccc ccg aag ctg cca gtc ccc ctc gag 1057 Phe Asp Val Phe Ser Gln Ser Pro Pro Lys Leu Pro Val Pro Leu Glu 340 345 350 ccc gag atg acc act gaa gtg agc cct tcc caa gtc tcc atc act gag 1105 Pro Glu Met Thr Thr Glu Val Ser Pro Ser Gln Val Ser Ile Thr Glu 355 360 365 gag gag gtg gga gag gag ccc gtg tcc act tct cac ttc tct acc tcc 1153 Glu Glu Val Gly Glu Glu Pro Val Ser Thr Ser His Phe Ser Thr Ser 370 375 380 cac ctg gtc tcc cac act gtg ttc cgg tgc cag ctc tgc aag tac ttc 1201 His Leu Val Ser His Thr Val Phe Arg Cys Gln Leu Cys Lys Tyr Phe 385 390 395 400 tgc tcc acg agg aag ggg atc gcc agg cac tac cgc atc aag cac aat 1249 Cys Ser Thr Arg Lys Gly Ile Ala Arg His Tyr Arg Ile Lys His Asn 405 410 415 aat gtc cga gcc cag cca gaa ggc aag aac aac ctc ttc aag tgt gcc 1297 Asn Val Arg Ala Gln Pro Glu Gly Lys Asn Asn Leu Phe Lys Cys Ala 420 425 430 ctg tgt gcc tac acc aac ccc atc cgc aaa ggt ctg gca gcc cac tac 1345 Leu Cys Ala Tyr Thr Asn Pro Ile Arg Lys Gly Leu Ala Ala His Tyr 435 440 445 cag aag cgc cac gac att gat gcg tat tac act cac tgc ttg gca gcc 1393 Gln Lys Arg His Asp Ile Asp Ala Tyr Tyr Thr His Cys Leu Ala Ala 450 455 460 tcc agg acc atc agc gac aag ccc aac aaa gtg atc atc cca tcc ccg 1441 Ser Arg Thr Ile Ser Asp Lys Pro Asn Lys Val Ile Ile Pro Ser Pro 465 470 475 480 ccc aag gac gac tcc cct cag ctg agc gag gaa ctc cgg cgg gca gtg 1489 Pro Lys Asp Asp Ser Pro Gln Leu Ser Glu Glu Leu Arg Arg Ala Val 485 490 495 gag aag aaa aag tgc tcc ttg tgc tct ttc cag tcg ttc agc aag aag 1537 Glu Lys Lys Lys Cys Ser Leu Cys Ser Phe Gln Ser Phe Ser Lys Lys 500 505 510 ggc atc gtg tcc cat tac atg aaa cgc cac cca ggg gtg ttc cca aag 1585 Gly Ile Val Ser His Tyr Met Lys Arg His Pro Gly Val Phe Pro Lys 515 520 525 aag cag cac gcc agc aag ttg ggg ggc tac ttc acg gcc gtc tat gca 1633 Lys Gln His Ala Ser Lys Leu Gly Gly Tyr Phe Thr Ala Val Tyr Ala 530 535 540 gat gag cat gag aag ccc aca ctg atg gaa gaa gag gag aga ggc aac 1681 Asp Glu His Glu Lys Pro Thr Leu Met Glu Glu Glu Glu Arg Gly Asn 545 550 555 560 ttt gag aaa gcc gag gtg gag ggt gaa gct cag gaa atc gag tgg ctc 1729 Phe Glu Lys Ala Glu Val Glu Gly Glu Ala Gln Glu Ile Glu Trp Leu 565 570 575 cca ttc cgc tgc atc aaa tgc ttc aag ctg tcc ttt agc act gca gag 1777 Pro Phe Arg Cys Ile Lys Cys Phe Lys Leu Ser Phe Ser Thr Ala Glu 580 585 590 ctg ctg tgc atg cat tac act gac cac cac agt cgg gac cta aag agg 1825 Leu Leu Cys Met His Tyr Thr Asp His His Ser Arg Asp Leu Lys Arg 595 600 605 gac ttc atc att ctg ggc aac ggc ccc cgc ttg cag aac tcc acc tac 1873 Asp Phe Ile Ile Leu Gly Asn Gly Pro Arg Leu Gln Asn Ser Thr Tyr 610 615 620 cag tgt aag cac tgt gat agc aaa ctg caa agc aca gcc gag ctg acc 1921 Gln Cys Lys His Cys Asp Ser Lys Leu Gln Ser Thr Ala Glu Leu Thr 625 630 635 640 tca cac ttg aac att cac aat gag gaa ttc cag aag cgt gcc aaa cgt 1969 Ser His Leu Asn Ile His Asn Glu Glu Phe Gln Lys Arg Ala Lys Arg 645 650 655 cag gag agg agg aaa cag ctt ttg agc aag cag aaa tat gca gat ggt 2017 Gln Glu Arg Arg Lys Gln Leu Leu Ser Lys Gln Lys Tyr Ala Asp Gly 660 665 670 gct ttt gca gat ttc aaa caa gag agg cct ttt ggt cac tta gaa gag 2065 Ala Phe Ala Asp Phe Lys Gln Glu Arg Pro Phe Gly His Leu Glu Glu 675 680 685 gtg cca aag atc aag gag agg aaa gtg gtg ggc tac aaa tgt aaa ttc 2113 Val Pro Lys Ile Lys Glu Arg Lys Val Val Gly Tyr Lys Cys Lys Phe 690 695 700 tgt gtg gaa gtg cac cca acg ctc cga gcc atc tgc aat cac ctc cga 2161 Cys Val Glu Val His Pro Thr Leu Arg Ala Ile Cys Asn His Leu Arg 705 710 715 720 aag cac gtc cag tat ggc aat gtc cca gct gtg tca gct gct gtg aag 2209 Lys His Val Gln Tyr Gly Asn Val Pro Ala Val Ser Ala Ala Val Lys 725 730 735 cag gag gcg gat gac cct gcc cac ttg ttc ctg gat gga ttg gaa gca 2257 Gln Glu Ala Asp Asp Pro Ala His Leu Phe Leu Asp Gly Leu Glu Ala 740 745 750 gcc aaa gac gcc agt ggc gcc ctg gtg ggc cgg gtg gat ggt gaa cac 2305 Ala Lys Asp Ala Ser Gly Ala Leu Val Gly Arg Val Asp Gly Glu His 755 760 765 tgc ttg ctt gat gga atg ttg gag gat gaa acc cgg ccg ggg gga tac 2353 Cys Leu Leu Asp Gly Met Leu Glu Asp Glu Thr Arg Pro Gly Gly Tyr 770 775 780 cat tgc agt caa tgt gac aga gtc ctg atg tcc atg cag ggg ctg cgt 2401 His Cys Ser Gln Cys Asp Arg Val Leu Met Ser Met Gln Gly Leu Arg 785 790 795 800 tct cat gag agg agc cac ctg gcc ctg gcc atg ttt acc cgc gag gac 2449 Ser His Glu Arg Ser His Leu Ala Leu Ala Met Phe Thr Arg Glu Asp 805 810 815 aag tac agc tgc cag tat tgc tcg ttt gtt tct gct ttc agg cac aat 2497 Lys Tyr Ser Cys Gln Tyr Cys Ser Phe Val Ser Ala Phe Arg His Asn 820 825 830 ttg gat cgc cat atg caa acc cac cac gga cac cat aaa cca ttc cga 2545 Leu Asp Arg His Met Gln Thr His His Gly His His Lys Pro Phe Arg 835 840 845 tgc aaa ctc tgc tcc ttc aag tcc tcc tat aac agc cgg ctg aaa aca 2593 Cys Lys Leu Cys Ser Phe Lys Ser Ser Tyr Asn Ser Arg Leu Lys Thr 850 855 860 cat ata ctc aaa gct cat gct ggt gag cat gcc tac aag tgt tct tgg 2641 His Ile Leu Lys Ala His Ala Gly Glu His Ala Tyr Lys Cys Ser Trp 865 870 875 880 tgc tca ttc tcc acc atg aca atc agc cag ctg aag gaa cac tcc ctc 2689 Cys Ser Phe Ser Thr Met Thr Ile Ser Gln Leu Lys Glu His Ser Leu 885 890 895 aag gtc cac gga aaa gcc ctg acc ctc ccc agg cca cgg atc gtc agt 2737 Lys Val His Gly Lys Ala Leu Thr Leu Pro Arg Pro Arg Ile Val Ser 900 905 910 ctc ctc tcc tca cac tcc cac cac tcc tcc caa aaa gct acc ccg gct 2785 Leu Leu Ser Ser His Ser His His Ser Ser Gln Lys Ala Thr Pro Ala 915 920 925 gaa gaa gtg gaa gac tcc aat gac tca tca tat tca gag ccc cca gat 2833 Glu Glu Val Glu Asp Ser Asn Asp Ser Ser Tyr Ser Glu Pro Pro Asp 930 935 940 gtt cag cag cag ttg aac cac tat cag tca gct gcc ctg gca agg aac 2881 Val Gln Gln Gln Leu Asn His Tyr Gln Ser Ala Ala Leu Ala Arg Asn 945 950 955 960 aac agc cgt gtt agc cct gtg cct ctt tct ggg gct gct gct ggc act 2929 Asn Ser Arg Val Ser Pro Val Pro Leu Ser Gly Ala Ala Ala Gly Thr 965 970 975 gag cag aaa act gaa gcc gtg ctt cac tgc gaa ttc tgt gaa ttc tcc 2977 Glu Gln Lys Thr Glu Ala Val Leu His Cys Glu Phe Cys Glu Phe Ser 980 985 990 tcc ggc tac atc cag agc atc agg cgt cat tac cgg gac aag cat ggt 3025 Ser Gly Tyr Ile Gln Ser Ile Arg Arg His Tyr Arg Asp Lys His Gly 995 1000 1005 ggg aag aag ctt ttc aag tgc aaa gac tgc tcc ttt tac aca ggc ttt 3073 Gly Lys Lys Leu Phe Lys Cys Lys Asp Cys Ser Phe Tyr Thr Gly Phe 1010 1015 1020 aaa tct gct ttt act atg cac gtg gaa gct ggg cac tca gca gtt ccc 3121 Lys Ser Ala Phe Thr Met His Val Glu Ala Gly His Ser Ala Val Pro 1025 1030 1035 1040 gag gag ggc ccc aaa gat ctt cgc tgt cct ctc tgc ctc tat cac acc 3169 Glu Glu Gly Pro Lys Asp Leu Arg Cys Pro Leu Cys Leu Tyr His Thr 1045 1050 1055 aaa tac aag cgc aac atg att gac cac atc gtg ctg cac cga gaa gag 3217 Lys Tyr Lys Arg Asn Met Ile Asp His Ile Val Leu His Arg Glu Glu 1060 1065 1070 cgt gtt gtc ccc att gaa gtt tgc cgg tcc aaa ctg tcc aaa tac ttg 3265 Arg Val Val Pro Ile Glu Val Cys Arg Ser Lys Leu Ser Lys Tyr Leu 1075 1080 1085 cag gga gta gtt ttc cgc tgt gat aag tgt acc ttc acc tgc tcc agt 3313 Gln Gly Val Val Phe Arg Cys Asp Lys Cys Thr Phe Thr Cys Ser Ser 1090 1095 1100 gat gag agc ctc cag caa cat ata gaa aag cac aat gaa ctg aaa cct 3361 Asp Glu Ser Leu Gln Gln His Ile Glu Lys His Asn Glu Leu Lys Pro 1105 1110 1115 1120 tac aaa tgc cag ctc tgc tac tat gag acc aag cac acg gag gaa ctg 3409 Tyr Lys Cys Gln Leu Cys Tyr Tyr Glu Thr Lys His Thr Glu Glu Leu 1125 1130 1135 gac agc cac ctt cgg gat gag cat aag gta agc cgt aac ttt gag ctg 3457 Asp Ser His Leu Arg Asp Glu His Lys Val Ser Arg Asn Phe Glu Leu 1140 1145 1150 gtt gga cgg gtt aac ttg gat cag ctg gaa cag atg aag gag aaa atg 3505 Val Gly Arg Val Asn Leu Asp Gln Leu Glu Gln Met Lys Glu Lys Met 1155 1160 1165 gag agc tcc agc agc gat gat gag gac aag gaa gaa gaa atg aac agc 3553 Glu Ser Ser Ser Ser Asp Asp Glu Asp Lys Glu Glu Glu Met Asn Ser 1170 1175 1180 aag gct gaa gac aga gag ctg atg aga ttt tct gac cac ggg gct gct 3601 Lys Ala Glu Asp Arg Glu Leu Met Arg Phe Ser Asp His Gly Ala Ala 1185 1190 1195 1200 ctt aac act gag aag cgt ttt cca tgt gaa ttt tgt gga cgg gcg ttt 3649 Leu Asn Thr Glu Lys Arg Phe Pro Cys Glu Phe Cys Gly Arg Ala Phe 1205 1210 1215 tca cag ggc tct gag tgg gaa aga cat gtg ctg aga cac ggc atg gca 3697 Ser Gln Gly Ser Glu Trp Glu Arg His Val Leu Arg His Gly Met Ala 1220 1225 1230 ttg aat gac acc aag cag gtg agc aga gaa gaa atc cac cca aaa gag 3745 Leu Asn Asp Thr Lys Gln Val Ser Arg Glu Glu Ile His Pro Lys Glu 1235 1240 1245 atc atg gag aac agt gtt aaa atg ccc tcc ata gag gaa aag gaa gat 3793 Ile Met Glu Asn Ser Val Lys Met Pro Ser Ile Glu Glu Lys Glu Asp 1250 1255 1260 gac gag gcc att ggg ata gac ttt tcc cta aag aat gaa aca gta gcc 3841 Asp Glu Ala Ile Gly Ile Asp Phe Ser Leu Lys Asn Glu Thr Val Ala 1265 1270 1275 1280 atc tgt gta gta act gcc gac aaa tct ctc ctg gag aat gca gag gcc 3889 Ile Cys Val Val Thr Ala Asp Lys Ser Leu Leu Glu Asn Ala Glu Ala 1285 1290 1295 aaa aaa gaa tgagcgtttg gtgaaattct taatcaaacc ttacttgaac 3938 Lys Lys Glu agtgatgaaa aagtgggagg gctggcttgg gctgagaagg gagggacaga aaagagaaga 3998 cagaacaaag ctgcttttta ggactgaaca atctattttc aaagcactgg tacctgtgtg 4058 agtgagtatg taaattaaag ttatttaaat ggttggaata tgtggctcct tttccatcac 4118 tacatctttt cttccggatc ttcatcatgg aagtttcatt tgttgcggaa tatggaagca 4178 cctcccaatg gtacggtgca ccctgtggtg gtcttggaca gtatgtggaa acagaagctc 4238 catgacggta gaagacttct cattggggag caactttttg acgcacaact tttggtgtgt 4298 ttttctagtt ttaatacctt aagctttttc aagacctaac tgcagccgct ttggg 4353 <210> 27 <211> 4007 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (97)..(1566) <400> 27 taattttctc attgttttca tgttttgagt aaggtagttt cacaactgat atgattcatt 60 tagctttttt aacaaagcca atattggtta atatga ttg ttg tgg tta ata tgg 114 Leu Leu Trp Leu Ile Trp 1 5 tta ata atg ttc ttt tta gtg act tca gat gaa agc aat aaa act tgg 162 Leu Ile Met Phe Phe Leu Val Thr Ser Asp Glu Ser Asn Lys Thr Trp 10 15 20 gga agg aac aca gtc ttt cga caa gaa gaa ttt gag gat gta aaa agg 210 Gly Arg Asn Thr Val Phe Arg Gln Glu Glu Phe Glu Asp Val Lys Arg 25 30 35 aat ttt aag aaa aaa ggt tgt acc tgg gga cca aat tcc att caa atg 258 Asn Phe Lys Lys Lys Gly Cys Thr Trp Gly Pro Asn Ser Ile Gln Met 40 45 50 aaa gat aga aca gat tgc aaa gaa agg ata aga cct ctc tcc gat ggc 306 Lys Asp Arg Thr Asp Cys Lys Glu Arg Ile Arg Pro Leu Ser Asp Gly 55 60 65 70 aac agt cct tgg tca act atc tta ata aaa aat cag aaa acc atg ccc 354 Asn Ser Pro Trp Ser Thr Ile Leu Ile Lys Asn Gln Lys Thr Met Pro 75 80 85 ttg gct tca ttg ttt gtg gac cag cca ggg tcc tgt gaa gag cca aaa 402 Leu Ala Ser Leu Phe Val Asp Gln Pro Gly Ser Cys Glu Glu Pro Lys 90 95 100 ctt tcc cct gat gga tta gaa cac aga aaa cca aaa caa ata aaa ttg 450 Leu Ser Pro Asp Gly Leu Glu His Arg Lys Pro Lys Gln Ile Lys Leu 105 110 115 cct agt cag gcc tac att gat cta cct ctt ggg aaa gat gct cag aga 498 Pro Ser Gln Ala Tyr Ile Asp Leu Pro Leu Gly Lys Asp Ala Gln Arg 120 125 130 gag aat cct gca gaa gct gaa agc tgg gag gag gca gcc tct gcg aat 546 Glu Asn Pro Ala Glu Ala Glu Ser Trp Glu Glu Ala Ala Ser Ala Asn 135 140 145 150 gct gcc aca gtc tcc att gag atg act cct acg aat agt ctg agt aga 594 Ala Ala Thr Val Ser Ile Glu Met Thr Pro Thr Asn Ser Leu Ser Arg 155 160 165 tcc ccc cag aga aag aaa acg gag tca gct ctg tat ggg tgc acc gtc 642 Ser Pro Gln Arg Lys Lys Thr Glu Ser Ala Leu Tyr Gly Cys Thr Val 170 175 180 ctt ctg gca tcg gtg gct ctg gga ctg gac ctc aga gag ctt cat aaa 690 Leu Leu Ala Ser Val Ala Leu Gly Leu Asp Leu Arg Glu Leu His Lys 185 190 195 gca cag gct gct gaa gaa ccg ttg ccc aag gaa gag aag aag aaa cga 738 Ala Gln Ala Ala Glu Glu Pro Leu Pro Lys Glu Glu Lys Lys Lys Arg 200 205 210 gag gga atc ttc cag cgg gct tcc aag tcc cgc aga agc gcc agt cct 786 Glu Gly Ile Phe Gln Arg Ala Ser Lys Ser Arg Arg Ser Ala Ser Pro 215 220 225 230 ccc aca agc ctg cca tcc acc tgt ggg gag gcc agc agc cca ccc tcc 834 Pro Thr Ser Leu Pro Ser Thr Cys Gly Glu Ala Ser Ser Pro Pro Ser 235 240 245 ctg cca ctg tca agt gcc ctg ggc atc ctc tcc aca cct tct ttc tcc 882 Leu Pro Leu Ser Ser Ala Leu Gly Ile Leu Ser Thr Pro Ser Phe Ser 250 255 260 aca aag tgc ctg ctg cag atg gac agt gaa gat cca ctg gtg gac agt 930 Thr Lys Cys Leu Leu Gln Met Asp Ser Glu Asp Pro Leu Val Asp Ser 265 270 275 gca cct gtc act tgt gac tct gag atg ctc act ccg gat ttt tgt ccc 978 Ala Pro Val Thr Cys Asp Ser Glu Met Leu Thr Pro Asp Phe Cys Pro 280 285 290 act gcc cca gga agt ggt cgt gag cca gcc ctc atg cca aga ctt gac 1026 Thr Ala Pro Gly Ser Gly Arg Glu Pro Ala Leu Met Pro Arg Leu Asp 295 300 305 310 act gat tgt agt gta tca aga aac ttg ccg tct tcc ttc cta cag cag 1074 Thr Asp Cys Ser Val Ser Arg Asn Leu Pro Ser Ser Phe Leu Gln Gln 315 320 325 aca tgt ggg aat gta cct tac tgt gct tct tca aaa cat aga cca tca 1122 Thr Cys Gly Asn Val Pro Tyr Cys Ala Ser Ser Lys His Arg Pro Ser 330 335 340 cat cac aga cgg acc atg tct gat gga aat ccg acc cca act ggt gca 1170 His His Arg Arg Thr Met Ser Asp Gly Asn Pro Thr Pro Thr Gly Ala 345 350 355 act att atc tca gcc act gga gcc tct gca ctg cca ctc tgc ccc tca 1218 Thr Ile Ile Ser Ala Thr Gly Ala Ser Ala Leu Pro Leu Cys Pro Ser 360 365 370 cct gct cct cac agt cat ctg cca agg gag gtc tca ccc aag aag cac 1266 Pro Ala Pro His Ser His Leu Pro Arg Glu Val Ser Pro Lys Lys His 375 380 385 390 agc act gtc cac atc gtg cct cag cgt cgc cct gcc tcc ctg aga agc 1314 Ser Thr Val His Ile Val Pro Gln Arg Arg Pro Ala Ser Leu Arg Ser 395 400 405 cgc tca gat ctg cct cag gct tac cca cag aca gca gtg tct cag ctg 1362 Arg Ser Asp Leu Pro Gln Ala Tyr Pro Gln Thr Ala Val Ser Gln Leu 410 415 420 gca cag act gcc tgt gta gtg ggt cgc cca gga cca cat ccc acc caa 1410 Ala Gln Thr Ala Cys Val Val Gly Arg Pro Gly Pro His Pro Thr Gln 425 430 435 ttc ctc gct gcc aag gag aga act aaa tcc cat gtg cct tca tta ctg 1458 Phe Leu Ala Ala Lys Glu Arg Thr Lys Ser His Val Pro Ser Leu Leu 440 445 450 gat gct gac gtg gaa ggt cag agc agg gac tac act gtg cca ctg tgc 1506 Asp Ala Asp Val Glu Gly Gln Ser Arg Asp Tyr Thr Val Pro Leu Cys 455 460 465 470 aga atg agg agc aaa acc agc cgg cca tct ata tat gaa ctg gag aaa 1554 Arg Met Arg Ser Lys Thr Ser Arg Pro Ser Ile Tyr Glu Leu Glu Lys 475 480 485 gaa ttc ctg tct taaactaagt gccttactgt tgtttaagca tttttttaag 1606 Glu Phe Leu Ser 490 gtgaacaaat gaacacaatg tatctacctt tgaactgttt catgctgctg tgttttcaaa 1666 agctgtggcc atgttcctaa attagtaaga tatatccagc ttctcaaaaa atgtatatga 1726 ttgctgttag ccatgtctat tgtttttcct ctggattctt ttcttataac ttggaataca 1786 caaaagtata aaacaagaga tgtgcaccaa tgaaaactat gctgggtcga attaccttca 1846 gcacaatgtt aatgttttcg ttctcattta tgcctttgtc catttgcaca caacagaaat 1906 tgtaatgagc ttcactattt ttgtttcttt ccttcctttt ttttcttttt tcctttcttt 1966 cctttttctt gtcttgtttc ttgttttttt ttcttgtagt ttcttttctt aattgtcatt 2026 tttgcaacaa aaagccaaga aagagcttta gtttcttggc aagaataatg tgatattagt 2086 aagtaaaggt tcttaaaagt ctgatgactg gaatagatat aaagtcctgt ttaaactacc 2146 taaccttggc tgtgggccga taatgcatat gtccagttct cacttaaatt atgcaatgat 2206 atttctctct gaggaaatta tacggaatgt aacttataaa agctttactg aatataagtt 2266 ataagcattt tattcattag aactccaaaa tagatgttca aagttcagtc cttgccattt 2326 gactgagacc acatggtgtg ccccttgagt gaggctaatc tttaggtttt tcctatagaa 2386 aacgttcttc ctccatcagt agccctttat ttgatattca gaagtggaaa gctttttcat 2446 tctccagtag aacttttaaa aattgttaca gatacctagc tcttcacaga tatcatgtat 2506 tgtaaacagt catgtgtctt aattttattt tctctatttg agtgcataat tatcctaata 2566 atcccaaaga cactgacaac tcaaggaaca gcagtacagt actattagaa gttaagtatg 2626 ttgttgttat ttcacatttc atttaattgt ggataaatgt tagacatctg ttgaaataag 2686 ctcatatggt ggaaacgaca actatattat gaattatttt cagaaatgga tctttgaata 2746 gcagatcagg atttaaataa taaaattatc tatgaatcac ttttatggtc atacatatat 2806 gatacaaatc cagagttatt ggtgcagaaa tggctacccg agagcttggt aaatttgcct 2866 tggtttctta tgttaaatgt attgtgcttc ccttctgtct ctagaatgtg gctcttcaga 2926 agacagacaa ttgacattta aatttttcca aacaatgaaa aactaaatta aaaacattgc 2986 ttgatatttc atttaaaatt gcaccttgct taaggtttac tgaataactg aaatgtcagc 3046 aatttaaaat aaattcaatt gtgtgataaa atatctcacc tataatagaa gaaaaggaaa 3106 atcatattat ttggcaattt tgcagcattg tggttgccta acaggtatat ccagcagatg 3166 agaaacagta tgaaaggatt gtattaacat ggtaagtttt gccctaagga aaacgatctt 3226 gcattctgga ttcttgcagc aaagtctcag gtacttaata cgttttcttg ttttatcatc 3286 tgttctatga ttcggcttca ctttgggtgg ttattgaatt atgtaacaga gatttggttt 3346 tcccaaaatg ttatcacatt tgaaactatg attgctttgt gttcagtcct tttggaacac 3406 gtagcttcca gcttaagggt agaggaaata tatacctaaa atcatcaata catgaaagaa 3466 aaaggatgga aactatgtcc tcagttttac ttctaccaaa acatccctgt atgtgtgtgc 3526 atgtatgttg gcgtgtgtgt gtgtgcatgc atattagtaa atgtgtgttt gcatgtgtgt 3586 gttggggagt gtatgtgatc tgggtgtttg tttatctctg ttattattcc cctttagctt 3646 tattttagtc aactctacat tatgatgaat ttcaaaatga agctgtatta aaataattgt 3706 aatataacaa ttcaatctca catgttactg cagatagtta acttttgctg caatctattg 3766 tacatttgca attttctgtg ttagtaaact tagcagaatc tggttattta tttttgtgta 3826 ggcttaatgt tcactgaaag ataagtcaat tactgttagt aaaaaattaa ggtactctca 3886 ctgcagagat ttaaggcctg ggcctaatgt gctgtattat gaagccttgt gactgaaaaa 3946 tatgtttaca tacgttgtct atttttttaa taaactttta tagctggtct atttgctcag 4006 t 4007 <210> 28 <211> 3237 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(1604) <400> 28 cc cag tgc tcc ata aag gat aat agt ttc cag tac act atc cct cat 47 Gln Cys Ser Ile Lys Asp Asn Ser Phe Gln Tyr Thr Ile Pro His 1 5 10 15 gat gac tcc tta agt ggt tca tcg tct gca tct tcg tgt gaa cca gtg 95 Asp Asp Ser Leu Ser Gly Ser Ser Ser Ala Ser Ser Cys Glu Pro Val 20 25 30 agt gat ttt cca gca tct ttc cga aaa tct acc tac tgg atg aag atg 143 Ser Asp Phe Pro Ala Ser Phe Arg Lys Ser Thr Tyr Trp Met Lys Met 35 40 45 aga aga atc aag cca gct gct act tct cat gtc gaa ggg tca ggt gga 191 Arg Arg Ile Lys Pro Ala Ala Thr Ser His Val Glu Gly Ser Gly Gly 50 55 60 gta tca gcc aag ggg aaa agg aaa ccc agg cag gaa gaa gat gaa gac 239 Val Ser Ala Lys Gly Lys Arg Lys Pro Arg Gln Glu Glu Asp Glu Asp 65 70 75 tat cga gaa ttt cct cag aag aag cat aag ctt tat ggg agg aag caa 287 Tyr Arg Glu Phe Pro Gln Lys Lys His Lys Leu Tyr Gly Arg Lys Gln 80 85 90 95 cgg cct aaa act cag ccc aat ccc aaa tcc cag gcc cgt cgt att cgg 335 Arg Pro Lys Thr Gln Pro Asn Pro Lys Ser Gln Ala Arg Arg Ile Arg 100 105 110 aag gaa cca cca gtt tat gca gca ggc agt ttg gag gag caa tgg tac 383 Lys Glu Pro Pro Val Tyr Ala Ala Gly Ser Leu Glu Glu Gln Trp Tyr 115 120 125 tta gaa atc gtt gat aaa ggc agt gtc tcc tgc cct acc tgc cag gca 431 Leu Glu Ile Val Asp Lys Gly Ser Val Ser Cys Pro Thr Cys Gln Ala 130 135 140 gtg ggg agg aag acc ata gag ggt tta aag aaa cac atg gaa aac tgc 479 Val Gly Arg Lys Thr Ile Glu Gly Leu Lys Lys His Met Glu Asn Cys 145 150 155 aag cag gaa atg ttt act tgt cat cat tgt ggg aaa caa ctt cgt tca 527 Lys Gln Glu Met Phe Thr Cys His His Cys Gly Lys Gln Leu Arg Ser 160 165 170 175 ctg gca ggg atg aag tat cat gtc atg gca aat cat aat agt ttg ccc 575 Leu Ala Gly Met Lys Tyr His Val Met Ala Asn His Asn Ser Leu Pro 180 185 190 att ttg aaa gcc gga gat gaa ata gat gag cca agt gag agg gaa agg 623 Ile Leu Lys Ala Gly Asp Glu Ile Asp Glu Pro Ser Glu Arg Glu Arg 195 200 205 ctc cga aca gtt cta aag aga ctg gga aag ctc agg tgc atg cgt gag 671 Leu Arg Thr Val Leu Lys Arg Leu Gly Lys Leu Arg Cys Met Arg Glu 210 215 220 agt tgc tcc agt agc ttc acc agc atc atg gga tat ctc tac cat gtc 719 Ser Cys Ser Ser Ser Phe Thr Ser Ile Met Gly Tyr Leu Tyr His Val 225 230 235 aga aaa tgt ggc aaa ggg gct gca gag ctg gaa aag atg acc ctg aaa 767 Arg Lys Cys Gly Lys Gly Ala Ala Glu Leu Glu Lys Met Thr Leu Lys 240 245 250 255 tgt cac cac tgt gga aaa cca tat agg tcg aag gct gga ctt gca tat 815 Cys His His Cys Gly Lys Pro Tyr Arg Ser Lys Ala Gly Leu Ala Tyr 260 265 270 cac ctg agg tca gag cat ggg cct ata tcc ttc ttt cca gag tca gga 863 His Leu Arg Ser Glu His Gly Pro Ile Ser Phe Phe Pro Glu Ser Gly 275 280 285 cag cca gag tgc tta aag gag atg aac cta gag tca aag agt ggg ggc 911 Gln Pro Glu Cys Leu Lys Glu Met Asn Leu Glu Ser Lys Ser Gly Gly 290 295 300 cga gtt cag aga cgt tct gcc aag ata gct gta tac cac cta cag gag 959 Arg Val Gln Arg Arg Ser Ala Lys Ile Ala Val Tyr His Leu Gln Glu 305 310 315 ctg gcc tct gct gaa ctg gcc aag gaa tgg ccc aag agg aag gtg ctt 1007 Leu Ala Ser Ala Glu Leu Ala Lys Glu Trp Pro Lys Arg Lys Val Leu 320 325 330 335 cag gac ctg gta cct gat gat cga aag tta aaa tat act cgt cca ggg 1055 Gln Asp Leu Val Pro Asp Asp Arg Lys Leu Lys Tyr Thr Arg Pro Gly 340 345 350 ctc cct acc ttc agc cag gaa gta cta cat aaa tgg aag aca gat atc 1103 Leu Pro Thr Phe Ser Gln Glu Val Leu His Lys Trp Lys Thr Asp Ile 355 360 365 aag aaa tat cat cgt att cag tgt cct aac cag ggc tgt gag gct gtc 1151 Lys Lys Tyr His Arg Ile Gln Cys Pro Asn Gln Gly Cys Glu Ala Val 370 375 380 tac agc agt gta tct ggc ctt aaa gct cac ctg ggc tct tgt aca ttg 1199 Tyr Ser Ser Val Ser Gly Leu Lys Ala His Leu Gly Ser Cys Thr Leu 385 390 395 gga aac ttt gtg gct gga aaa tac aaa tgt ctt cta tgt cag aaa gaa 1247 Gly Asn Phe Val Ala Gly Lys Tyr Lys Cys Leu Leu Cys Gln Lys Glu 400 405 410 415 ttt gtg tca gag agt ggt gtc aag tat cac atc aac tcc gtc cat gct 1295 Phe Val Ser Glu Ser Gly Val Lys Tyr His Ile Asn Ser Val His Ala 420 425 430 gag gac tgg ttc gtt gta aac cca aca aca acc aaa agc ttt gaa aag 1343 Glu Asp Trp Phe Val Val Asn Pro Thr Thr Thr Lys Ser Phe Glu Lys 435 440 445 ctg atg aag ata aag cag cgg cag caa gaa gaa gaa aag cgg agg cag 1391 Leu Met Lys Ile Lys Gln Arg Gln Gln Glu Glu Glu Lys Arg Arg Gln 450 455 460 cag cac agg agc aga agg tct cta aga agg cgg cag cag cct ggc att 1439 Gln His Arg Ser Arg Arg Ser Leu Arg Arg Arg Gln Gln Pro Gly Ile 465 470 475 gag ctt ccc gag aca gag ctg agt ctt aga gta ggg aag gat cag agg 1487 Glu Leu Pro Glu Thr Glu Leu Ser Leu Arg Val Gly Lys Asp Gln Arg 480 485 490 495 agg aat aat gag gaa ctg gta gtg tca gcc tcc tgt aag gaa cca gag 1535 Arg Asn Asn Glu Glu Leu Val Val Ser Ala Ser Cys Lys Glu Pro Glu 500 505 510 cag gag cca gtg cca gca cag ttc cag aaa gta aag ccc cca aag act 1583 Gln Glu Pro Val Pro Ala Gln Phe Gln Lys Val Lys Pro Pro Lys Thr 515 520 525 aat cat aaa cga gga agg aaa taggcagtca gtgtaaaagt gctcctagga 1634 Asn His Lys Arg Gly Arg Lys 530 aagcagatgt gatgctgttg tcacggggac ctgtgctggg aggactgagt gaagattctt 1694 tcagctgttt gtgtaaggct gtgactttct cagctccttc ctcctgtgta aatttcactg 1754 tcttcccttc ttacattttg attcccccct ccccttttag taggttttcc tgctattcct 1814 cgtcaagtcc tcttgttttt ttatcttgcc caaagagctc cctctcaagg ccaactatag 1874 gctcctcttg ccctgtacaa aactaagaaa cctctttggt tgtcctttcc ttcctggggt 1934 atagaatgtt cttggaagct ccattgattt agtagctgct ccatcatcta gcttgtgaaa 1994 ccattccaaa ctaatttttt aaaaccataa ctgatttgtc attttgtatt tgtgatataa 2054 caagtctaga agttagaact gttgtcattc acataataag attactctgt ctccttggga 2114 aaaaaacttt atggaggctg tttgtcctct caatatggtt ttaagattga aagtaagaaa 2174 acggatttag gatgaaaact ctagaactac cctatgctgt ttatactggg aaatgctttg 2234 taccaagtag cagtgactag acccacagac atgaaaagca accttaggag taaagtgacc 2294 caaacattaa aatgacagga aagagaaagt agaagcagca ataaatactg ccccaacttt 2354 cctggagccc gaggcctcat ccatagctat gatcacttgc cctctgaagc ttatttttgc 2414 ttctttggtt ttaagaattg agaaatatca cattgcccct gatgttttga cagtctccta 2474 gtgctcctgg tagtgccact aagggaaaac caaggtgcgc attccttctc cctggacttt 2534 accttacttg ttagtctacg ccccactgtt tccacccatc cccttagcca acctctgtct 2594 ttttgaattt tctgagaata ttgtcctatc ctcttttata tatggagttc tctcctcttt 2654 atatcctgag actttgacac cagatgtaga tatttatctg gagctggaaa gaaaaattct 2714 ttttctgtac ctcatgccta tctggtaatg tttaatgggt tatttctctt tgagggtggc 2774 tttctctgga acattggtta gagcagcttt gttgtcgtgt ttctggattc tcttccccat 2834 tttgcgtaaa tattggtctt atatattctt gcctattttg tggcatatgc cacataaaaa 2894 atgaacctga tatagacaag tactaccttt tcaaattctg aaaggctatt accactttaa 2954 ctctttgtgc tcctccaaat agctttaaaa tgtgggcttt tgtgaagacc actttcaaac 3014 aagggagcac tgaaacctga attggatact gccagaatag gtagttttga aacaagttaa 3074 ggacatggta tatgcactct gcattttcat tggcagtgtg cccttaaagc cctttcagta 3134 gatgagggtt gtcagggagg agaaatgaag aagctatgtt aatttctggt gagtaagacc 3194 tggggaatgt ttggcaatga caaaagaaat aaatgactct cag 3237 <210> 29 <211> 3079 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1443) <400> 29 gtg gag gaa gaa gct atg gct cct ggg ctg cca acc gcc tgt tca cag 48 Val Glu Glu Glu Ala Met Ala Pro Gly Leu Pro Thr Ala Cys Ser Gln 1 5 10 15 gaa cca gtc acc ttt gca gat gtg gct gtg gtg ttc acc cca gaa gaa 96 Glu Pro Val Thr Phe Ala Asp Val Ala Val Val Phe Thr Pro Glu Glu 20 25 30 tgg gtg ttt ctg gac tct act cag agg agc ctg tat aga gat gtg atg 144 Trp Val Phe Leu Asp Ser Thr Gln Arg Ser Leu Tyr Arg Asp Val Met 35 40 45 ctg gag aac tac agg aac ctg gcc tct gtg gct gat caa ctg tgc aaa 192 Leu Glu Asn Tyr Arg Asn Leu Ala Ser Val Ala Asp Gln Leu Cys Lys 50 55 60 ccc aat gcg ttg tct tat ttg gaa gaa aga gga gag cag tgg acc act 240 Pro Asn Ala Leu Ser Tyr Leu Glu Glu Arg Gly Glu Gln Trp Thr Thr 65 70 75 80 gac agg ggc gtc ctc tca gac acc tgt gca gaa cct cag tgt caa ccc 288 Asp Arg Gly Val Leu Ser Asp Thr Cys Ala Glu Pro Gln Cys Gln Pro 85 90 95 caa gag gca att cct agc caa gat act ttt aca gag atc ctg tcc att 336 Gln Glu Ala Ile Pro Ser Gln Asp Thr Phe Thr Glu Ile Leu Ser Ile 100 105 110 gat gtg aaa ggg gag caa cct cag cct gga gaa aaa ctc tat aaa tat 384 Asp Val Lys Gly Glu Gln Pro Gln Pro Gly Glu Lys Leu Tyr Lys Tyr 115 120 125 aat gaa ctt gag aaa cct ttt aac agc att gaa cca ctt ttc cag tac 432 Asn Glu Leu Glu Lys Pro Phe Asn Ser Ile Glu Pro Leu Phe Gln Tyr 130 135 140 cag aga att cat gct gga gag gca tcc tgt gaa tgt caa gag att aga 480 Gln Arg Ile His Ala Gly Glu Ala Ser Cys Glu Cys Gln Glu Ile Arg 145 150 155 160 aat tcc ttc ttc cag agt gcc cac cta att gtg ccc gag aaa atc cgt 528 Asn Ser Phe Phe Gln Ser Ala His Leu Ile Val Pro Glu Lys Ile Arg 165 170 175 agt ggg gat aaa tcc tat gca tgt aac aaa tgt gaa aaa tcc ttc aga 576 Ser Gly Asp Lys Ser Tyr Ala Cys Asn Lys Cys Glu Lys Ser Phe Arg 180 185 190 tac agc tct gac ctt atc agg cat gag aag act cat act gca gag aag 624 Tyr Ser Ser Asp Leu Ile Arg His Glu Lys Thr His Thr Ala Glu Lys 195 200 205 tgc ttt gac tgt caa gaa tgt ggg caa gcc ttc aaa tat tcc tcg aat 672 Cys Phe Asp Cys Gln Glu Cys Gly Gln Ala Phe Lys Tyr Ser Ser Asn 210 215 220 ctc cgg cga cac atg aga acc cat acc gga gag aag cca ttt gaa tgt 720 Leu Arg Arg His Met Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys 225 230 235 240 agt cag tgt ggg aaa acc ttc acg agg aac ttt aac ctg att ttg cac 768 Ser Gln Cys Gly Lys Thr Phe Thr Arg Asn Phe Asn Leu Ile Leu His 245 250 255 cag aga aac cac aca gga gag aag ccc tac gag tgt aaa gat tgt ggg 816 Gln Arg Asn His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Asp Cys Gly 260 265 270 aaa gcc ttc aat cag cca tca tcc ctc agg agc cac gtg aga act cac 864 Lys Ala Phe Asn Gln Pro Ser Ser Leu Arg Ser His Val Arg Thr His 275 280 285 act gga gag aag ccc ttt gaa tgc agc cag tgt ggg aaa gcc ttc agg 912 Thr Gly Glu Lys Pro Phe Glu Cys Ser Gln Cys Gly Lys Ala Phe Arg 290 295 300 gaa cac tct tca ctg aag aca cat ctg cga acc cat acc aga gag aaa 960 Glu His Ser Ser Leu Lys Thr His Leu Arg Thr His Thr Arg Glu Lys 305 310 315 320 cca tat gaa tgc aac cag tgt ggc aag ccc ttc cgg acg agc act cat 1008 Pro Tyr Glu Cys Asn Gln Cys Gly Lys Pro Phe Arg Thr Ser Thr His 325 330 335 ctg aac gtg cac aag agg ata cac aca ggg gag aaa ctg tat gag tgc 1056 Leu Asn Val His Lys Arg Ile His Thr Gly Glu Lys Leu Tyr Glu Cys 340 345 350 gcg act tgc ggt cag gtc ttg agt cgt ctt tca acc ctg aag agt cac 1104 Ala Thr Cys Gly Gln Val Leu Ser Arg Leu Ser Thr Leu Lys Ser His 355 360 365 atg cga act cac act gga gag aag ccc tat gtg tgc cag gaa tgt ggg 1152 Met Arg Thr His Thr Gly Glu Lys Pro Tyr Val Cys Gln Glu Cys Gly 370 375 380 cga gcc ttc agt gag ccc tca tcc ctc agg aaa cat gca agg act cac 1200 Arg Ala Phe Ser Glu Pro Ser Ser Leu Arg Lys His Ala Arg Thr His 385 390 395 400 agt ggc aag aag ccc tat gca tgc cag gaa tgc ggg cga gcc ttt ggt 1248 Ser Gly Lys Lys Pro Tyr Ala Cys Gln Glu Cys Gly Arg Ala Phe Gly 405 410 415 cag tct tca cat ctt att gta cat gtg aga aca cac agt gcc ggg aga 1296 Gln Ser Ser His Leu Ile Val His Val Arg Thr His Ser Ala Gly Arg 420 425 430 ccc tat caa tgt aat cag tgt gag aaa gcc ttc agg cac agc tcc tca 1344 Pro Tyr Gln Cys Asn Gln Cys Glu Lys Ala Phe Arg His Ser Ser Ser 435 440 445 ctc act gta cac aaa aga acc cat gtg gga aga gag acc att agg aat 1392 Leu Thr Val His Lys Arg Thr His Val Gly Arg Glu Thr Ile Arg Asn 450 455 460 ggc agc ctg cct tta tcc atg tct cat cca tac tgt ggg ccc ctt gct 1440 Gly Ser Leu Pro Leu Ser Met Ser His Pro Tyr Cys Gly Pro Leu Ala 465 470 475 480 aat taacttccat tttgtaaaaa tataaacaca tggggctatg actttccctc 1493 Asn gtaatactcc tttagctgca tcctgtgttt caatgtataa tattttcatt ttggtttaat 1553 tgtaagtatt gtcttaacct ccattatcgt ttattctttg acccatctat tatttggaat 1613 tagatttttc aaaactaata tgtggatata ttttcataga ggtataatga cttatagtga 1673 aatgcataca tctgaagtgt acagttggat gagtttgaca gatgcataca tgcatgtaac 1733 caccacccca ttccagatat agaatgtttc tatctctctg gaaggttcct gcatgttata 1793 tggctatttc ttagttgcct ttttgttgtt ggtttctaat ttaattacat ggtgagaaga 1853 gtatgtggcc tctttgttac tgagtcatag gtatttgctg agatttgcta ttaggtctgg 1913 tgtggcttat tcttctagct gccaacccaa attacccctt cctccttaga aaagaacctg 1973 ggttttctgt tcagattggc agtgtgcact attaaaaagc ttccatctcc cggctgggca 2033 cggtggctca tgcctctaat cccagcactt tgggaggctg aggctggggg atcacctgag 2093 gtcaggagtt cgagatcagc ctggccaaca tggtgaaatc ccctctctac taaaaatata 2153 aaaattagcc aagtttggtg gcatgcacct gtaatcccag ctacttggga ggctgaggca 2213 ggagaattct ttgaacccag gaggcagagg ttgcagtgag ccgagattgc gccactgcac 2273 tccagcctgg gcaacagagt gaaactctgt ctcaaaaata ataataataa aaaaaagctt 2333 ccatctccca gcccttcttg caagcaaggg caggccattt cctccggtcc tggctagtat 2393 gaatatgaga agtcactgga tgtgactctg gggaagatat tgtgttcagg gatggtttca 2453 tgtagccaca tctctccact tcttgccttt tggacaagta gacatgattt ctagacctag 2513 aggagccctc ctgtgaccat aagggtaaaa gccgcaagct aagaagaggg tggccggaag 2573 tcataaccat cttgcttctg taatctaaaa aatatttagg atagatttaa tagaattggc 2633 atatttatgt gattgcagca gccctggact atttatttct ggatgtccca tacatgaaaa 2693 atatgcactt cttactggta cagttttctt ttgtttgttt ttgtttttgg tgggaggttt 2753 atttcacctg aatataattc ctaactgatg cacttagtat atgtcagttt ttataaatgc 2813 ttcatggatg gttgaaatca atgtattgta ttctacaaat gtctgctaga tcaagcaaat 2873 gtgtttaaaa accatctaca catttataaa tgttgatctg tgatctagca tttattgaga 2933 gaggtatgtt aaactctccc accatgatta tgtattgctg aaaaatcttt gtcattctgt 2993 cagtttttaa atttatgtat atacatacat atatatgttt tgaagcaatg aaattaaata 3053 tagatactga cattttttac atttcc 3079 <210> 30 <211> 3567 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (701)..(2200) <400> 30 ctctgagtta gagtcggtaa aggaaaacaa gccatacata ttgcagcaga gcggctttaa 60 cacaaggagc tggctaccca gctgtgggag ggctagaaag caaatgggaa cgctgagtaa 120 cctaacagta gagattgcag ggagcagtta ccttgcctag ggctgagaaa ctaaacgaga 180 agattaggat ttccagaagc cacaagcatt gaggagagat cctgtggacc actgtccaag 240 tacggctgca gctctgaggg gcccaaggag ctggttatgg gatcattggg aaaagttgga 300 gtctgcaatc aactgcccct accgagagga ccctgatgag aacagcagca tgcagaaagg 360 agcaagcctg ctctgtcctc ctaccttcca gtcgccctct tggtccccct tttggctgta 420 cctaacagtt ggaaaaagga gaacatggtt tgcagggctc tggcatcact tagtagagga 480 tagaagagtg agtgtggagc agggacagtc gcttaataaa gggcaagggg ctgactcaca 540 agacctgccc aactcagcca gagctgttct gccaggggcc agaaaggcca tagggccctg 600 acttgcactg ccactgccag ctgtgactct agaactttgc aaagcacctt tccacttact 660 tataataact ggtagtaagt gacggccatg tcttccttag aat gta aaa tac tac 715 Asn Val Lys Tyr Tyr 1 5 caa ggt atc cgg gct gcc gtg agc agg gtg aag gac aga gga cag aag 763 Gln Gly Ile Arg Ala Ala Val Ser Arg Val Lys Asp Arg Gly Gln Lys 10 15 20 gcc ttg gtt ctc gac att ggc act ggc acg gga ctc ttg tca atg atg 811 Ala Leu Val Leu Asp Ile Gly Thr Gly Thr Gly Leu Leu Ser Met Met 25 30 35 gcg gtc aca gca ggt gcc gac ttc tgc tat gcc atc gag gaa aat tgt 859 Ala Val Thr Ala Gly Ala Asp Phe Cys Tyr Ala Ile Glu Glu Asn Cys 40 45 50 gag gcc gtg ccc cac aga gcc acc gtc tat gca cag ctg gtg gag tcc 907 Glu Ala Val Pro His Arg Ala Thr Val Tyr Ala Gln Leu Val Glu Ser 55 60 65 ggg agg atg tgg tcg tgg aac aag cta ttt ccc atc cac gtg cag acc 955 Gly Arg Met Trp Ser Trp Asn Lys Leu Phe Pro Ile His Val Gln Thr 70 75 80 85 agc ctc gga gag cag gtc atc gtc cct ccc gtt gac gtg gag agc tgc 1003 Ser Leu Gly Glu Gln Val Ile Val Pro Pro Val Asp Val Glu Ser Cys 90 95 100 cct ggc gca ccc tct gtc tgt gac att cag ctg aac cag gtg tca cca 1051 Pro Gly Ala Pro Ser Val Cys Asp Ile Gln Leu Asn Gln Val Ser Pro 105 110 115 gcc gac ttt aca gtc ctc agc gat gtg ctg ccc atg ttc agc ata gac 1099 Ala Asp Phe Thr Val Leu Ser Asp Val Leu Pro Met Phe Ser Ile Asp 120 125 130 ttc agc aag caa gtc agt agc tca gca gcc tgc cat agc agg cgg ttt 1147 Phe Ser Lys Gln Val Ser Ser Ser Ala Ala Cys His Ser Arg Arg Phe 135 140 145 gaa cct ctg aca tct ggc cga gct cag gtg gtt ctc tcg tgg tgg gac 1195 Glu Pro Leu Thr Ser Gly Arg Ala Gln Val Val Leu Ser Trp Trp Asp 150 155 160 165 att gaa atg gac cct gag ggg aag atc aag tgc acc atg gcc ccc ttc 1243 Ile Glu Met Asp Pro Glu Gly Lys Ile Lys Cys Thr Met Ala Pro Phe 170 175 180 tgg gca cac tca gac cca gag gag atg cag tgg cgg gac cac tgg atg 1291 Trp Ala His Ser Asp Pro Glu Glu Met Gln Trp Arg Asp His Trp Met 185 190 195 cag tgt gtg tac ttc ctg cca caa gag gag cct gtg gtg cag ggc tca 1339 Gln Cys Val Tyr Phe Leu Pro Gln Glu Glu Pro Val Val Gln Gly Ser 200 205 210 gcg ctc tat ctg gta gcc cac cac gat gac tac tgc gta tgg tac agc 1387 Ala Leu Tyr Leu Val Ala His His Asp Asp Tyr Cys Val Trp Tyr Ser 215 220 225 ctg cag agg acc agc cct gaa aag aat gag aga gtc cgc cag atg cgc 1435 Leu Gln Arg Thr Ser Pro Glu Lys Asn Glu Arg Val Arg Gln Met Arg 230 235 240 245 ccc gtg tgt gac tgc cag gct cac ctg ctc tgg aac cgg cct cgg ttt 1483 Pro Val Cys Asp Cys Gln Ala His Leu Leu Trp Asn Arg Pro Arg Phe 250 255 260 gga gag atc aat gac cag gac aga act gat cga tac gtc cag gct ctg 1531 Gly Glu Ile Asn Asp Gln Asp Arg Thr Asp Arg Tyr Val Gln Ala Leu 265 270 275 agg acc gtc tct ctc ctc ctg ggc gag ccg ttc ttc act acc agc ctg 1579 Arg Thr Val Ser Leu Leu Leu Gly Glu Pro Phe Phe Thr Thr Ser Leu 280 285 290 ctg ccg tgg cac aac ctc tac ttc tgg tac gtg cgg acc gct gtg gac 1627 Leu Pro Trp His Asn Leu Tyr Phe Trp Tyr Val Arg Thr Ala Val Asp 295 300 305 cag cac ctg ggg cca ggt gcc atg gtg atg ccc cag gca gcc tcg ctg 1675 Gln His Leu Gly Pro Gly Ala Met Val Met Pro Gln Ala Ala Ser Leu 310 315 320 325 cac gct gtg gtt gtg gag ttc agg gac ctg tgg cgg atc cgg agc ccc 1723 His Ala Val Val Val Glu Phe Arg Asp Leu Trp Arg Ile Arg Ser Pro 330 335 340 tgt ggt gac tgc gaa ggc ttc gac gtg cac atc atg gac gac atg att 1771 Cys Gly Asp Cys Glu Gly Phe Asp Val His Ile Met Asp Asp Met Ile 345 350 355 aag cgt gcc ctg gac ttc agg gag agc agg gaa gct gag ccc cac ccg 1819 Lys Arg Ala Leu Asp Phe Arg Glu Ser Arg Glu Ala Glu Pro His Pro 360 365 370 ctg tgg gag tac cca tgc cgc agc ctc tcc gag ccc tgg cag atc ctg 1867 Leu Trp Glu Tyr Pro Cys Arg Ser Leu Ser Glu Pro Trp Gln Ile Leu 375 380 385 acc ttt gac ttc cag cag ccg gtg ccc ctg cag ccc ctg tgt gcc gag 1915 Thr Phe Asp Phe Gln Gln Pro Val Pro Leu Gln Pro Leu Cys Ala Glu 390 395 400 405 ggc acc gtg gag ctc aga agg ccc ggg cag agc cac gca gcg gtg cta 1963 Gly Thr Val Glu Leu Arg Arg Pro Gly Gln Ser His Ala Ala Val Leu 410 415 420 tgg atg gag tac cac ctg acc ccg gag tgc acg ctc agc act ggc ctc 2011 Trp Met Glu Tyr His Leu Thr Pro Glu Cys Thr Leu Ser Thr Gly Leu 425 430 435 ctg gag cct gca gac cct gag ggg ggc tgc tgc tgg aac ccc cac tgc 2059 Leu Glu Pro Ala Asp Pro Glu Gly Gly Cys Cys Trp Asn Pro His Cys 440 445 450 aag cag gcc gtc tac ttc ttc agc cct gcc cca gat ccc aga gca ctg 2107 Lys Gln Ala Val Tyr Phe Phe Ser Pro Ala Pro Asp Pro Arg Ala Leu 455 460 465 ctg ggt ggc cca cgg act gtc agc tat gca gtg gag ttt cac ccc gac 2155 Leu Gly Gly Pro Arg Thr Val Ser Tyr Ala Val Glu Phe His Pro Asp 470 475 480 485 aca ggc gac atc atc atg gag ttc agg cat gca gat acc cca gac 2200 Thr Gly Asp Ile Ile Met Glu Phe Arg His Ala Asp Thr Pro Asp 490 495 500 tgaccactct tgagcaataa agtggcctga gggctggggt tctgagtggc tcatggcttt 2260 ctagggggga aggctgaagg ccctcctctc ctctctggga gctgctcggc ctcagggatg 2320 ggaaagactg cgccgtgttg catcttgttg catctttgca ctgctggcct ctggctccag 2380 ctgtggcagg aagcatgaga gggtgactga atttggagcc ctggaggggc tgggaagacc 2440 cccctgcttg tgcttctgag gtgctgagaa tgctccaaca cagagacatc tctccccagc 2500 tgggaaggga gtggaagcac agggagcttg tggggctggc cggtggggtt gtccacgccg 2560 cccttggcga gcagtccccg tggcgggagc ctgtcctgtc tgtctcactc tcgaggatct 2620 ccgggtccct gctcttctgg cttctgctag gagggtggag atttctggcc ctctagtggg 2680 tggagatgct gagttgtggc tgggtctctg gggcttgaag accctggctg ggcccgggct 2740 gagaggcctg ggttctggcc ctttcacctg acaggtaact tcaagccaca tccataggtg 2800 tctggcctca gtgctgcacc agctggtggc ctgccaggac ctgagactgg acacaaggca 2860 gctgtcccag agcagttcct gagatgcagg cccaggaaag tggctgtcag gggagctggg 2920 aggcagccct gttccctgca cctccctcag attggaaagc ccctcctgca ggtggggtat 2980 ggcagggagc agcccctgcc cagcgccgct tcaccaggaa ggtcagtagg tgccgtggcc 3040 ttgcttctct cacacactaa cccccctttg gttatgtccc agctctcaga ggtaacagca 3100 gacaccacgt gagagaaccc agtggcctct ggctcgcagc ttagaaggtg aggcttgtgc 3160 caggccagcc gagccgcctg tatgagcaga gttccggtgt cctcggattc agggcagact 3220 tgggcagtgc ctgtcctgca gttgggggca ggaactccct cccctgcccc caggcgtgcc 3280 cctgaggcct ggccccaact tgtcgctgaa ataagtggag aacaccagcc ttgagcctca 3340 cagttttatt ttctcctcgt tatccatcct tcctttcagc accagtaagg aaaaagaaca 3400 cctctcttcg caaaatattt tatcaggtgt aaagacttgt ttttcttcta gggaagaacc 3460 gtctggatat atatttgata atgtttttac caaaaccata ggtgtgctta ccatagaaaa 3520 cccctaatgt cccatgaaga tacaatacag aaaaaaatac agaaatt 3567 <210> 31 <211> 3140 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(2107) <400> 31 c tat gac ctc aat gac atg gat gct gca tgg ctg gaa ctg acc aat gaa 49 Tyr Asp Leu Asn Asp Met Asp Ala Ala Trp Leu Glu Leu Thr Asn Glu 1 5 10 15 gaa ttt aag gag atg gga atg cct gaa cta gat gaa tac acc atg gag 97 Glu Phe Lys Glu Met Gly Met Pro Glu Leu Asp Glu Tyr Thr Met Glu 20 25 30 agg gtc cta gag gaa ttt gag cag cga tgc tac gac aat atg aat cat 145 Arg Val Leu Glu Glu Phe Glu Gln Arg Cys Tyr Asp Asn Met Asn His 35 40 45 gcc ata gag act gag gaa ggc ctg ggg atc gaa tat gat gaa gat gtt 193 Ala Ile Glu Thr Glu Glu Gly Leu Gly Ile Glu Tyr Asp Glu Asp Val 50 55 60 gtc tgt gat gtc tgc cag tct cct gat ggt gag gac ggc aat gag atg 241 Val Cys Asp Val Cys Gln Ser Pro Asp Gly Glu Asp Gly Asn Glu Met 65 70 75 80 gtg ttc tgt gac aaa tgc aac atc tgt gtg cac cag gcc tgt tat gga 289 Val Phe Cys Asp Lys Cys Asn Ile Cys Val His Gln Ala Cys Tyr Gly 85 90 95 atc ctc aag gta cca gag ggc agc tgg ctg tgc cgg aca tgt gcc ctg 337 Ile Leu Lys Val Pro Glu Gly Ser Trp Leu Cys Arg Thr Cys Ala Leu 100 105 110 ggg gtt cag cca aaa tgt ctg ctg tgt ccg aag aag ggt gga gct atg 385 Gly Val Gln Pro Lys Cys Leu Leu Cys Pro Lys Lys Gly Gly Ala Met 115 120 125 aag ccc acc cgt agc gga acc aag tgg gtc cac gtt agc tgt gct ctg 433 Lys Pro Thr Arg Ser Gly Thr Lys Trp Val His Val Ser Cys Ala Leu 130 135 140 tgg atc cct gag gtg agc att ggc agc cca gag aag atg gag ccc atc 481 Trp Ile Pro Glu Val Ser Ile Gly Ser Pro Glu Lys Met Glu Pro Ile 145 150 155 160 acc aag gtg tca cac att ccc agc agc cgg tgg gcg cta gtg tgc agc 529 Thr Lys Val Ser His Ile Pro Ser Ser Arg Trp Ala Leu Val Cys Ser 165 170 175 ctc tgc aat gag aag ttt ggg gcc tct ata cag tgc tct gtg aag aac 577 Leu Cys Asn Glu Lys Phe Gly Ala Ser Ile Gln Cys Ser Val Lys Asn 180 185 190 tgc cgc aca gcc ttc cat gtg acc tgt gct ttt gac cgg ggc ctg gag 625 Cys Arg Thr Ala Phe His Val Thr Cys Ala Phe Asp Arg Gly Leu Glu 195 200 205 atg aag acc atc tta gca gag aat gat gaa gtc aag ttc aag tcc tat 673 Met Lys Thr Ile Leu Ala Glu Asn Asp Glu Val Lys Phe Lys Ser Tyr 210 215 220 tgc cca aag cac agc tca cat agg aaa ccc gag gag agt ctt ggc aag 721 Cys Pro Lys His Ser Ser His Arg Lys Pro Glu Glu Ser Leu Gly Lys 225 230 235 240 ggg gct gca cag gag aat ggg gcc cct gag tgt tcc ccc cgg aat ccg 769 Gly Ala Ala Gln Glu Asn Gly Ala Pro Glu Cys Ser Pro Arg Asn Pro 245 250 255 ctg gag ccc ttt gcc agc ctt gag cag aac cgg gag gag gcc cac cgg 817 Leu Glu Pro Phe Ala Ser Leu Glu Gln Asn Arg Glu Glu Ala His Arg 260 265 270 gtg agt gtc cgt aag cag aag ctg cag cag ttg gag gat gag ttc tac 865 Val Ser Val Arg Lys Gln Lys Leu Gln Gln Leu Glu Asp Glu Phe Tyr 275 280 285 acc ttc gtc aac ctg ctg gat gtt gcc agg gct ctg cgg ctg cct gag 913 Thr Phe Val Asn Leu Leu Asp Val Ala Arg Ala Leu Arg Leu Pro Glu 290 295 300 gaa gta gtg gat ttc ctg tac cag tac tgg aag ttg aag agg aag gtc 961 Glu Val Val Asp Phe Leu Tyr Gln Tyr Trp Lys Leu Lys Arg Lys Val 305 310 315 320 aac ttc aac aag ccc ctg atc acc cca aag aaa gat gaa gag gac aat 1009 Asn Phe Asn Lys Pro Leu Ile Thr Pro Lys Lys Asp Glu Glu Asp Asn 325 330 335 cta gcc aag cgg gag cag gat gtc tta ttt agg agg ctg cag ctg ttc 1057 Leu Ala Lys Arg Glu Gln Asp Val Leu Phe Arg Arg Leu Gln Leu Phe 340 345 350 acg cac ctg cgg cag gac ctg gag agg gtt cgg aac ctc act tac atg 1105 Thr His Leu Arg Gln Asp Leu Glu Arg Val Arg Asn Leu Thr Tyr Met 355 360 365 gtg acc cgc agg gaa aag att aaa cgg tct gtg tgc aaa gtc cag gaa 1153 Val Thr Arg Arg Glu Lys Ile Lys Arg Ser Val Cys Lys Val Gln Glu 370 375 380 cag ata ttc aat ctt tac act aag ctt ttg gag caa gaa aga gtt tca 1201 Gln Ile Phe Asn Leu Tyr Thr Lys Leu Leu Glu Gln Glu Arg Val Ser 385 390 395 400 ggt gtg cct tct tcc tgc tcc tcc tcc tca ctg gaa aac atg ctt ttg 1249 Gly Val Pro Ser Ser Cys Ser Ser Ser Ser Leu Glu Asn Met Leu Leu 405 410 415 ttt aac agt cct tct gtt ggc cct gat gct ccc aag ata gag gac ttg 1297 Phe Asn Ser Pro Ser Val Gly Pro Asp Ala Pro Lys Ile Glu Asp Leu 420 425 430 aag tgg cat tct gca ttc ttc aga aaa caa atg ggt act tcc ttg gtt 1345 Lys Trp His Ser Ala Phe Phe Arg Lys Gln Met Gly Thr Ser Leu Val 435 440 445 cat tcg ctg aaa aag ccc cat aag cga gat cct ttg cag aat agc cct 1393 His Ser Leu Lys Lys Pro His Lys Arg Asp Pro Leu Gln Asn Ser Pro 450 455 460 gga agt gaa ggc aaa acc ctg ctg aag cag cca gac ctg tgt ggt aga 1441 Gly Ser Glu Gly Lys Thr Leu Leu Lys Gln Pro Asp Leu Cys Gly Arg 465 470 475 480 agg gag ggg atg gtg gtc cca gag agc ttt ttg ggt tta gaa aag acc 1489 Arg Glu Gly Met Val Val Pro Glu Ser Phe Leu Gly Leu Glu Lys Thr 485 490 495 ttt gca gaa gca cgt ctc ata tca gca caa cag aaa aat ggt gtg gtg 1537 Phe Ala Glu Ala Arg Leu Ile Ser Ala Gln Gln Lys Asn Gly Val Val 500 505 510 atg cca gac cat ggg aaa aga aga gac aat cgt ttt cat tgt gat ctc 1585 Met Pro Asp His Gly Lys Arg Arg Asp Asn Arg Phe His Cys Asp Leu 515 520 525 att aaa gga gac tta aag gac aaa tct ttt aaa cag agt cac aag cct 1633 Ile Lys Gly Asp Leu Lys Asp Lys Ser Phe Lys Gln Ser His Lys Pro 530 535 540 ctc agg tcc aca gat gtg tcc cag agg cat ctg gac aac aca aga gct 1681 Leu Arg Ser Thr Asp Val Ser Gln Arg His Leu Asp Asn Thr Arg Ala 545 550 555 560 gcc acc tcc cct gga gtg ggg cag tca gca cct ggc aca agg aag gag 1729 Ala Thr Ser Pro Gly Val Gly Gln Ser Ala Pro Gly Thr Arg Lys Glu 565 570 575 ata gtg ccc aag tgc aat ggc tcc cta atc aaa gta aac tat aat cag 1777 Ile Val Pro Lys Cys Asn Gly Ser Leu Ile Lys Val Asn Tyr Asn Gln 580 585 590 act gca gtc aaa gtg cct aca aca cct gcc agc cca gtg aaa aac tgg 1825 Thr Ala Val Lys Val Pro Thr Thr Pro Ala Ser Pro Val Lys Asn Trp 595 600 605 gga gga ttc cgg att cca aag aag ggg gaa cgg cag cag cag gga gag 1873 Gly Gly Phe Arg Ile Pro Lys Lys Gly Glu Arg Gln Gln Gln Gly Glu 610 615 620 gcc cac gat ggg gcc tgc cac cag cac tca gac tac cca tat ttg ggc 1921 Ala His Asp Gly Ala Cys His Gln His Ser Asp Tyr Pro Tyr Leu Gly 625 630 635 640 tta ggc cga gtt cca gcc aag gaa agg gca aaa agc aaa tta aaa tcc 1969 Leu Gly Arg Val Pro Ala Lys Glu Arg Ala Lys Ser Lys Leu Lys Ser 645 650 655 gac aat gag aat gac ggg tat gtc ccc gat gtg gaa atg agt gac tca 2017 Asp Asn Glu Asn Asp Gly Tyr Val Pro Asp Val Glu Met Ser Asp Ser 660 665 670 gag agt gag gca tca gaa aag aaa tgt ata cac acc agc agc act atc 2065 Glu Ser Glu Ala Ser Glu Lys Lys Cys Ile His Thr Ser Ser Thr Ile 675 680 685 agc aga agg aca gac att atc agg aga agc atc ttg gct tct 2107 Ser Arg Arg Thr Asp Ile Ile Arg Arg Ser Ile Leu Ala Ser 690 695 700 tgatgcaaca gagatgatgc ggaagccctt tgggctcgtc attgggtttg ctagaggaga 2167 gctctgatgt gggggagaag cagaaaccca ttaatcctga gctacacaaa cacatttact 2227 tgcaattcag attaattttt ttccagagtc atttttaaat catttttgtg agaagtttgt 2287 gttatttgca acttgttgag gaaacagaag agtagattgt aaccataaga cactgctaag 2347 actagaaccc gaactgaaca ctaaaataaa aatgaaatgt tttaaagaag gcaaggctta 2407 aataagcctc atgaattttt atagccctct gcattcttcc caaagcacaa actcatggtt 2467 acctgaatat agggaaccag atatggttct tgagaaaccc tcatggtacc attcacagcc 2527 cataaagttt attttctagg actgtggtag atcttgaaat catatttata tttggccctc 2587 aaggctattt ttgttgcatt atagcatata ggcagcagct ctgaagcttc agtaacacta 2647 agaaatttat gtgtaaatat agcagtcagg gaagagaatt ttaaaaaagg tcattattga 2707 agaagctgag gggacagggt agagctgctg caatatggag atttagggta atatggcaag 2767 gtcctgctgc ttgaagcctg tgagtgggtt gtggatatgg gactggtgga gagtgagact 2827 gttaggaaag ttgtatctat gaataagggc agttgaagta gaatttttac cagtccactt 2887 gaccttcttc ttccctaacc actggctctt gagccagctt gggatttccc tggccattgc 2947 caatacctgg ccatctggct tccaatagta cagtggctac tcaagttcaa gcgaagaact 3007 tccagactct ggtgactgtt acttcccaga gccaaccact agtgcatatg ttagggaatc 3067 tgggcttcca acatgaatgg attccttaag aaaaaggaaa aaaaagaaaa aaagaaaaaa 3127 agaaaaaaaa aag 3140 <210> 32 <211> 3282 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(1618) <400> 32 c gag gtg ctg cgg gtg cag gac aag tac ttc cac atc aag tgc ttc gtc 49 Glu Val Leu Arg Val Gln Asp Lys Tyr Phe His Ile Lys Cys Phe Val 1 5 10 15 tgt aaa gca tgt ggc tgc gac ctg gcc gag ggc ggc ttc ttc gtg cgg 97 Cys Lys Ala Cys Gly Cys Asp Leu Ala Glu Gly Gly Phe Phe Val Arg 20 25 30 cag ggc gag tac atc tgc acg ctg gac tac cag agg ctc tac ggc acc 145 Gln Gly Glu Tyr Ile Cys Thr Leu Asp Tyr Gln Arg Leu Tyr Gly Thr 35 40 45 cgc tgc ttc agc tgc gac cag ttc att gag ggt gag gtg gtg tcg gcg 193 Arg Cys Phe Ser Cys Asp Gln Phe Ile Glu Gly Glu Val Val Ser Ala 50 55 60 ctg ggc aag acc tac cac ccc gac tgc ttc gtg tgt gcc gtc tgc cgg 241 Leu Gly Lys Thr Tyr His Pro Asp Cys Phe Val Cys Ala Val Cys Arg 65 70 75 80 ctg ccc ttc ccc ccc ggg gac cga gtg acc ttc aac ggg aag gaa tgc 289 Leu Pro Phe Pro Pro Gly Asp Arg Val Thr Phe Asn Gly Lys Glu Cys 85 90 95 atg tgc cag aag tgt tcc ctg ccc gta tcg gtg ggc agc agc gcg cac 337 Met Cys Gln Lys Cys Ser Leu Pro Val Ser Val Gly Ser Ser Ala His 100 105 110 ctg tcc cag ggc ctc cga agt tgt ggg ggc tgc ggc aca gaa atc aag 385 Leu Ser Gln Gly Leu Arg Ser Cys Gly Gly Cys Gly Thr Glu Ile Lys 115 120 125 aat ggc cag gcc ctg gta gcc ttg gac aag cac tgg cac ttg ggc tgt 433 Asn Gly Gln Ala Leu Val Ala Leu Asp Lys His Trp His Leu Gly Cys 130 135 140 ttt aag tgc aag agc tgt ggg aag ctc ctg aat gcc gag tac atc agc 481 Phe Lys Cys Lys Ser Cys Gly Lys Leu Leu Asn Ala Glu Tyr Ile Ser 145 150 155 160 aag gat ggg ctg ccc tac tgc gaa gct gac tat cac gcc aag ttc ggc 529 Lys Asp Gly Leu Pro Tyr Cys Glu Ala Asp Tyr His Ala Lys Phe Gly 165 170 175 atc cgc tgt gac agc tgt gag aaa tac atc acg ggg cgc gtg ctg gag 577 Ile Arg Cys Asp Ser Cys Glu Lys Tyr Ile Thr Gly Arg Val Leu Glu 180 185 190 gcc gga gag aag cac tac cac cct tcc tgc gcg cta tgt gtc agg tgc 625 Ala Gly Glu Lys His Tyr His Pro Ser Cys Ala Leu Cys Val Arg Cys 195 200 205 ggc cag atg ttt gca gaa ggc gaa gag atg tat ctt caa ggt tcc tcc 673 Gly Gln Met Phe Ala Glu Gly Glu Glu Met Tyr Leu Gln Gly Ser Ser 210 215 220 atc tgg cat ccg gcg tgt cga caa gca gcc aga act gaa gac aga aac 721 Ile Trp His Pro Ala Cys Arg Gln Ala Ala Arg Thr Glu Asp Arg Asn 225 230 235 240 aag gaa acc aga act tcc tca gag agc atc att tct gtc cct gct tcc 769 Lys Glu Thr Arg Thr Ser Ser Glu Ser Ile Ile Ser Val Pro Ala Ser 245 250 255 agc acc tca ggg tct ccg agc cgt gtg att tat gcc aag ctt ggt ggt 817 Ser Thr Ser Gly Ser Pro Ser Arg Val Ile Tyr Ala Lys Leu Gly Gly 260 265 270 gag atc ctg gac tac agg gac ttg gca gcc ctt cct aaa agt aag gcc 865 Glu Ile Leu Asp Tyr Arg Asp Leu Ala Ala Leu Pro Lys Ser Lys Ala 275 280 285 atc tat gac atc gac cgc ccc gac atg atc tcc tac tca ccc tac atc 913 Ile Tyr Asp Ile Asp Arg Pro Asp Met Ile Ser Tyr Ser Pro Tyr Ile 290 295 300 agc cac tct gca ggg gac agg cag agc tac ggc gag ggg gat cag gat 961 Ser His Ser Ala Gly Asp Arg Gln Ser Tyr Gly Glu Gly Asp Gln Asp 305 310 315 320 gac cgg tcc tac aag cag tgc cgg acc tcc agc cca agc tcc act ggg 1009 Asp Arg Ser Tyr Lys Gln Cys Arg Thr Ser Ser Pro Ser Ser Thr Gly 325 330 335 tcg gtt agc ctc ggg cgc tac act ccg acc tca cgg tca cca cag cac 1057 Ser Val Ser Leu Gly Arg Tyr Thr Pro Thr Ser Arg Ser Pro Gln His 340 345 350 tac agc cgt cca ggc agt gaa agt ggc cgg agc acc ccc agc ctc tcc 1105 Tyr Ser Arg Pro Gly Ser Glu Ser Gly Arg Ser Thr Pro Ser Leu Ser 355 360 365 gtg ctc tct gac agc aag ccg ccc ccc tcc acc tac cag cag gca cct 1153 Val Leu Ser Asp Ser Lys Pro Pro Pro Ser Thr Tyr Gln Gln Ala Pro 370 375 380 cgc cac ttc cac gtc cca gac act ggc gta aaa gat aac atc tat agg 1201 Arg His Phe His Val Pro Asp Thr Gly Val Lys Asp Asn Ile Tyr Arg 385 390 395 400 aaa ccc cct atc tac aga cag cat gct gcc agg cga tcg gat ggg gag 1249 Lys Pro Pro Ile Tyr Arg Gln His Ala Ala Arg Arg Ser Asp Gly Glu 405 410 415 gat gga agc ttg gac cag gat aac agg aag aag agc agc tgg ctg atg 1297 Asp Gly Ser Leu Asp Gln Asp Asn Arg Lys Lys Ser Ser Trp Leu Met 420 425 430 ctc aag ggg gat gca gac aca agg acc aat tct cca gac ctg gac acc 1345 Leu Lys Gly Asp Ala Asp Thr Arg Thr Asn Ser Pro Asp Leu Asp Thr 435 440 445 cag tcc ttg tcc cac agc agc ggg acc gac aga gac cct ctc caa agg 1393 Gln Ser Leu Ser His Ser Ser Gly Thr Asp Arg Asp Pro Leu Gln Arg 450 455 460 atg gca ggg gac agc ttt cac tca caa tac aag atc tat ccg tat gac 1441 Met Ala Gly Asp Ser Phe His Ser Gln Tyr Lys Ile Tyr Pro Tyr Asp 465 470 475 480 tcc ctc atc gtc aca aac cga att cgc gtg aaa ctg ccc aaa gac gtg 1489 Ser Leu Ile Val Thr Asn Arg Ile Arg Val Lys Leu Pro Lys Asp Val 485 490 495 gac cgg acg aga ctg gag aga cac ttg tcg ccc gag gag ttc cag gaa 1537 Asp Arg Thr Arg Leu Glu Arg His Leu Ser Pro Glu Glu Phe Gln Glu 500 505 510 gtg ttt ggg atg agc atc gag gag ttt gac cgc ctg gcc ctc tgg aag 1585 Val Phe Gly Met Ser Ile Glu Glu Phe Asp Arg Leu Ala Leu Trp Lys 515 520 525 agg aat gac ctt aag aag aaa gcc ctt ttg ttc tgacggctgc cagcctgccc 1638 Arg Asn Asp Leu Lys Lys Lys Ala Leu Leu Phe 530 535 cactggtgtg tgccgggcgc cgaggccagg ggcccctggc gagaaccgca cacacccctc 1698 ccacacacct tgctctggct tctctgtgtc catggggtgg gcgggagggg gtcccccagc 1758 aggtgcggcc cctgcacctg ccggcgacac tcctgccggt agtttagggc cgagacggct 1818 agcttcacgc cacccttccc cgctgtggct tggtgtcagg gagaggctgt agagtggctg 1878 tgtcgggcat cagatggagc acacaggtgg ctgcagccca gcccaccttc ccagcgttct 1938 cgaggtgccc tggccccggt gctgggcacg tgggggacag aggtggccgg gacgtgagct 1998 gtgaggcttg ttgatgacgg gtgctgacac catcatcggg ggtgggcaca cggcccttcg 2058 gagcctgggc agcctggcct cacaggcaga ctcgcagacg gggcagtgag cgtctgggac 2118 agtgccaaga gtggggtgtg tgatttttgc aggcgtctgt gatgggtctc tttagggaca 2178 aatgtcaaca agggacaaga cagggcacct tccgccagcg cccctccatg cgctgcgttc 2238 ctcctccaga tcgaccccta gatgcctaca caatatcttt aaagtaacac agaagttttt 2298 attttattaa aaagtatagc ctacttaaac gcgagatgac atatatagag tttaatttta 2358 cggtccctcc gcaggggagc ggcctccagc cttattctcc accgctcgga tctgtgtggt 2418 ttcagtctgt tcttggtgtg gtcctcatac acagagctcc ctgtctagtt tcttttcttt 2478 ttcttttttc tttttctcgt cacacaggta accttaaaga cagacccctc taaagaacgc 2538 tttgtaaata catgtgaggt atagccacca ctgttttcct tgctgttatt tttccaagtc 2598 ttggggagaa aacatcctcc tctgatggcc aaagccctgg aatcaagggt ttccacgtac 2658 cctgcctaat acccgacgta gctcttgatg caccgtcctt gtgctgtggc tggcggtgtc 2718 tcagcctgaa acataaaccc cacatgcccc aggagcgatg tgctccctga aacagacaac 2778 cacacgctgt tggggagaga aggatggaga taggatggag ataggatgga gatgtggctc 2838 ttctcatctt tgaagccagc agggcatccc ggagcaggag gctggccggg ctccccaagc 2898 gaaggcgttg gtgtctgtca ttaggtgtgt gttagggtgc agcaccggcc gtcacaggat 2958 gctgataagc gcgctgagag gtggatgaaa caccaaagtc tgtttccccg tccgcagtgg 3018 gtgttgcctc tttgtgtgtg tcccgatgtt cctgcctgtg agtcggcctt actccgtttc 3078 cttagcgccc atgacacgcc aagtcccgtt tcgcactcgg cttctcaccc gcccagctcg 3138 gctagggagg gggagttttt agcacctaat atgcttcctg ccattgcgca atctgagcct 3198 gagcaactgg aaacccccat ttctcattag tgcaatgtca tatctgatcc caggaagcct 3258 ggaaaataaa agacgatgca ttat 3282 <210> 33 <211> 3072 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1407) <400> 33 tcg acc cac gcg tcc gat aat ttt gat cat gct cca tta ctt cca caa 48 Ser Thr His Ala Ser Asp Asn Phe Asp His Ala Pro Leu Leu Pro Gln 1 5 10 15 gaa cag aaa gca cac att agg gaa aaa gct tat aaa tgt aat gag cac 96 Glu Gln Lys Ala His Ile Arg Glu Lys Ala Tyr Lys Cys Asn Glu His 20 25 30 ggc caa gtc ttt aga gca tct gca agc ctt act aac caa gta atc cat 144 Gly Gln Val Phe Arg Ala Ser Ala Ser Leu Thr Asn Gln Val Ile His 35 40 45 aac gca gat aat cct tac aaa tgc agt gaa tgt ggc aag gtc ttt agt 192 Asn Ala Asp Asn Pro Tyr Lys Cys Ser Glu Cys Gly Lys Val Phe Ser 50 55 60 tgc agt tca aag ctt gtg ata cat cga aga atg cat act gga gag aag 240 Cys Ser Ser Lys Leu Val Ile His Arg Arg Met His Thr Gly Glu Lys 65 70 75 80 cct tac aaa tgt cat gaa tgt ggc aag ctc ttc agt agc aat tca aac 288 Pro Tyr Lys Cys His Glu Cys Gly Lys Leu Phe Ser Ser Asn Ser Asn 85 90 95 ctt tca caa cat caa aga att cat act gga gag aag cct tac aaa tgt 336 Leu Ser Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 100 105 110 cat gaa tgt gac aag gtc ttt cga agc agt tca aag ctt gca caa cat 384 His Glu Cys Asp Lys Val Phe Arg Ser Ser Ser Lys Leu Ala Gln His 115 120 125 caa aga att cat act gga gag aag cct tac aaa tgt cat gaa tgt gac 432 Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys His Glu Cys Asp 130 135 140 aag gtc ttc aat caa att gca cac ctt gta cga cat caa aaa att cat 480 Lys Val Phe Asn Gln Ile Ala His Leu Val Arg His Gln Lys Ile His 145 150 155 160 act gga gag aaa cct tac agt tgt aat aaa tgt ggc aag gtc ttt agt 528 Thr Gly Glu Lys Pro Tyr Ser Cys Asn Lys Cys Gly Lys Val Phe Ser 165 170 175 cgc cat tca tat cta gca gaa cat caa acg gtt cat act ggt gag aaa 576 Arg His Ser Tyr Leu Ala Glu His Gln Thr Val His Thr Gly Glu Lys 180 185 190 cct tac aaa tgt gaa gaa tgt ggc aaa gca ttt tca gtg cgt tcc agc 624 Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Val Arg Ser Ser 195 200 205 ctc ata acc cat cag tta att cac act gga agg aaa cct tac aaa tgt 672 Leu Ile Thr His Gln Leu Ile His Thr Gly Arg Lys Pro Tyr Lys Cys 210 215 220 aaa gaa tgt gac aag gtc ttt ggg cgc aag tgt ttc ctg acc tct cat 720 Lys Glu Cys Asp Lys Val Phe Gly Arg Lys Cys Phe Leu Thr Ser His 225 230 235 240 cag aga att cat act aga gag aga cct tat gga tgc agt cag tgt ggc 768 Gln Arg Ile His Thr Arg Glu Arg Pro Tyr Gly Cys Ser Gln Cys Gly 245 250 255 aag atc ttt agt cag aaa tca gac ctt ata cga cat cga aaa act cat 816 Lys Ile Phe Ser Gln Lys Ser Asp Leu Ile Arg His Arg Lys Thr His 260 265 270 act gat gag aag cct tac aaa tgt aat aaa tgt ggc aca gcg ttt aga 864 Thr Asp Glu Lys Pro Tyr Lys Cys Asn Lys Cys Gly Thr Ala Phe Arg 275 280 285 gag ttt tca gac ctt act gcc cat ttt cta atc cat agt gga gag aaa 912 Glu Phe Ser Asp Leu Thr Ala His Phe Leu Ile His Ser Gly Glu Lys 290 295 300 cct tat gaa tgt aaa gaa tgt ggc aaa gtc ttc agg tac aag tct tct 960 Pro Tyr Glu Cys Lys Glu Cys Gly Lys Val Phe Arg Tyr Lys Ser Ser 305 310 315 320 cta acc agt cat cat aga att cat act gga gag aag cct tac aaa tgt 1008 Leu Thr Ser His His Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 325 330 335 aac aga tgt ggc aag gtc ttc agt cgc agt tca aac ctg gta tgc cat 1056 Asn Arg Cys Gly Lys Val Phe Ser Arg Ser Ser Asn Leu Val Cys His 340 345 350 cag aaa att cat aca gga gaa aag cct tac aaa tgt aat caa tgt ggc 1104 Gln Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Gln Cys Gly 355 360 365 aag gtc ttt aat caa gca tca tac ctt aca aga cat caa ata att cat 1152 Lys Val Phe Asn Gln Ala Ser Tyr Leu Thr Arg His Gln Ile Ile His 370 375 380 act gga gag agg cct tac aga tgt agt aaa tgt ggc aaa gca ttt cga 1200 Thr Gly Glu Arg Pro Tyr Arg Cys Ser Lys Cys Gly Lys Ala Phe Arg 385 390 395 400 ggg tgt tca ggc ctt act gcc cat ctt gca atc cat act gaa aag aaa 1248 Gly Cys Ser Gly Leu Thr Ala His Leu Ala Ile His Thr Glu Lys Lys 405 410 415 tct cat gag tgt aaa gaa tgt ggc aag atc ttc act cag aag tct tcc 1296 Ser His Glu Cys Lys Glu Cys Gly Lys Ile Phe Thr Gln Lys Ser Ser 420 425 430 ctc acc aat cac cat aga att cac att gga gag aaa cct tac aaa tgc 1344 Leu Thr Asn His His Arg Ile His Ile Gly Glu Lys Pro Tyr Lys Cys 435 440 445 acc ctg tgc agt aag gtc ttc agt cac aat tct gac ctt gca cag cat 1392 Thr Leu Cys Ser Lys Val Phe Ser His Asn Ser Asp Leu Ala Gln His 450 455 460 cag aga gtt cat tca tgagagtccc tacaaactgt gtatggcaaa accatcatca 1447 Gln Arg Val His Ser 465 tgagttctag cattaatcaa catcagtgag tccatactaa gtggaaatca tataaatgaa 1507 atgtatgtga cacaggcttt atcaaggcct gccaaatcac tggacatcac cacatcactg 1567 tggaggatga aagcacacag atgaattgtg tgtacttggg ctattattca aggaccattg 1627 ctatagaaca cgataggatt tacacaagaa gtaactctgt ctctggttct ctgatactaa 1687 tctatgatat tgcatgatgc agaataatgc taagtcaaaa tatgttgaat ctcatgacct 1747 gatgtatatc aaaggtgcaa cggcttgtaa atgaccagtt ttattcaggc tataaagcat 1807 tcaattattt ggggcttata gaaaaggcta ctttactctt tgtgacttcg aaatcttttc 1867 atgtgccttc catacaggcc attcactgtg gtccctggga aagaatcagt aggatgacag 1927 ggctgacttc attagctgag gattatttct atccaatttc ctgatgaagg acattgcctt 1987 ttgagattaa atattgtctg atttagagag catggaggtg ggcagagtaa cataaaactg 2047 atgaccgtca tcatactgtt gcagttagca cactttctcc tgacataagt gcacagagct 2107 tcagtgtcca ccaactgacc atgaaataga gtatgctgta atcttaaggc ataggttatt 2167 agtgggaaga gagtaatagg ttgctagtgt ctgattatat ggtagaaata atgcaaggaa 2227 aaaggtagcc accttctcca ttgaacagca gtacctgctg tttagcaaag actgatgaga 2287 agtagacttt tttttttttg gagatagagt ctcactctgt tgcccaggct ggagtgtagt 2347 ggtgtgttct tggctcactg caccctccgc ctcctgggct caagcagtcc ttctgcctta 2407 gcctcctaag tagctgagac tacagacgtg cgccaccaca cccagttcat ttttgtattt 2467 ttagtagagg cagtgtttac catgttggcc aggcaggtct ccaactcctg acctcaagtg 2527 atatgttcac ctcagcctcc caaagtgctg ggattacagg catgaaccat ggtgcccagc 2587 ctcatttttg aaatggaata gagaacagtt atatcacagt tgagagttta atcaaaatga 2647 ccggatcagc atattctttt tttagatgag acggagtttc gcccttgtca cccaggctgt 2707 agtgcggtgg cgcgatctcg gctcactgca acctccgcct cccgggttca agcaatgctc 2767 ctgcctcagc ctcccaagta gctgggatta caggcgtgta ccaccatacc cagctaattt 2827 ttgtattttt agtagagatg gggtttcacc acgttggcca cactggtctc aaactcctga 2887 cctcaggcga tccatctgcc tcagcctgaa agtgctagga ttacaggcgt gagccaccac 2947 acctggccag ctcagcatat tcttaagtag gattcacatt taattcttgg tattataagt 3007 tgcaaccatt tgatttagaa tgtatgcagc tctcatgttt gtagtaataa agtttcattt 3067 ttcct 3072 <210> 34 <211> 2841 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1737) <400> 34 gcg ggc tcg cgg cgc tgg gtt cct ggt ctc cgg gcc agg gca atg ttc 48 Ala Gly Ser Arg Arg Trp Val Pro Gly Leu Arg Ala Arg Ala Met Phe 1 5 10 15 cgc acg gca gtg atg atg gcg gcc agc ctg gcg ctg acc ggg gct gtg 96 Arg Thr Ala Val Met Met Ala Ala Ser Leu Ala Leu Thr Gly Ala Val 20 25 30 gtg gct cac gcc tac tac ctc aaa cac cag ttc tac ccc act gtg gtg 144 Val Ala His Ala Tyr Tyr Leu Lys His Gln Phe Tyr Pro Thr Val Val 35 40 45 tac ctg acc aag tcc agc ccc agc atg gca gtc ctg tac atc cag gcc 192 Tyr Leu Thr Lys Ser Ser Pro Ser Met Ala Val Leu Tyr Ile Gln Ala 50 55 60 ttt gtc ctt gtc ttc ctt ctg ggc aag gtg atg ggc aag gtg ttc ttt 240 Phe Val Leu Val Phe Leu Leu Gly Lys Val Met Gly Lys Val Phe Phe 65 70 75 80 ggg caa ctg agg gca gca gag atg gag cac ctt ctg gaa cgt tcc tgg 288 Gly Gln Leu Arg Ala Ala Glu Met Glu His Leu Leu Glu Arg Ser Trp 85 90 95 tac gcc gtc aca gag act tgt ctg gcc ttc acc gtt ttt cgg gat gac 336 Tyr Ala Val Thr Glu Thr Cys Leu Ala Phe Thr Val Phe Arg Asp Asp 100 105 110 ttc agc ccc cgc ttt gtt gca ctc ttc act ctt ctt ctc ttc ctc aaa 384 Phe Ser Pro Arg Phe Val Ala Leu Phe Thr Leu Leu Leu Phe Leu Lys 115 120 125 tgt ttc cac tgg ctg gct gag gac cgt gtg gac ttt tat gcc atc ctg 432 Cys Phe His Trp Leu Ala Glu Asp Arg Val Asp Phe Tyr Ala Ile Leu 130 135 140 atg acg atg gtg ctc acc atc ttc atc aag tat gtg ctg cac tcc gtg 480 Met Thr Met Val Leu Thr Ile Phe Ile Lys Tyr Val Leu His Ser Val 145 150 155 160 gac ctc cag agt gag aac ccc tgg gac aac aag gct gtg tac atg ctc 528 Asp Leu Gln Ser Glu Asn Pro Trp Asp Asn Lys Ala Val Tyr Met Leu 165 170 175 tac aca gag ctg ttt aca ggc ttc atc aag gtt ctg ctg tac atg gcc 576 Tyr Thr Glu Leu Phe Thr Gly Phe Ile Lys Val Leu Leu Tyr Met Ala 180 185 190 ttc atg acc atc atg atc aag gtg cac acc ttc cca ctc ttt gcc atc 624 Phe Met Thr Ile Met Ile Lys Val His Thr Phe Pro Leu Phe Ala Ile 195 200 205 cgg ccc atg tac ctg gcc atg aga cag ttc aag aaa gct gtg aca gat 672 Arg Pro Met Tyr Leu Ala Met Arg Gln Phe Lys Lys Ala Val Thr Asp 210 215 220 gcc atc atg tct cgc cga gcc atc cgc aac atg aac acc ctg tat cca 720 Ala Ile Met Ser Arg Arg Ala Ile Arg Asn Met Asn Thr Leu Tyr Pro 225 230 235 240 gat gcc acc cca gag gag ctc cag gca atg gac aat gtc tgc atc atc 768 Asp Ala Thr Pro Glu Glu Leu Gln Ala Met Asp Asn Val Cys Ile Ile 245 250 255 tgc cga gaa gag atg gtg act ggt gcc aag aga ctg ccc tgc aac cac 816 Cys Arg Glu Glu Met Val Thr Gly Ala Lys Arg Leu Pro Cys Asn His 260 265 270 att ttc cat acc agc tgc ctg cgc tcc tgg ttc cag cgg cag cag acc 864 Ile Phe His Thr Ser Cys Leu Arg Ser Trp Phe Gln Arg Gln Gln Thr 275 280 285 tgc ccc acc tgc cgt atg gat gtc ctt cgt gca tcg ctg cca gcg cag 912 Cys Pro Thr Cys Arg Met Asp Val Leu Arg Ala Ser Leu Pro Ala Gln 290 295 300 tca cca cca ccc ccg gag cct gcg gat cag ggg cca ccc cct gcc ccc 960 Ser Pro Pro Pro Pro Glu Pro Ala Asp Gln Gly Pro Pro Pro Ala Pro 305 310 315 320 cac ccc cca cca ctc ttg cct cag ccc ccc aac ttc ccc cag ggc ctc 1008 His Pro Pro Pro Leu Leu Pro Gln Pro Pro Asn Phe Pro Gln Gly Leu 325 330 335 ctg cct cct ttt cct cca ggc atg ttc cca ctg tgg ccc ccc atg ggc 1056 Leu Pro Pro Phe Pro Pro Gly Met Phe Pro Leu Trp Pro Pro Met Gly 340 345 350 ccc ttt cca cct gtc ccg cct ccc ccc agc tca gga gag gct gtg gct 1104 Pro Phe Pro Pro Val Pro Pro Pro Pro Ser Ser Gly Glu Ala Val Ala 355 360 365 cct cca tcc acc agt gca gcc ctt tct cgg ccc agt gga gca gct aca 1152 Pro Pro Ser Thr Ser Ala Ala Leu Ser Arg Pro Ser Gly Ala Ala Thr 370 375 380 acc aca gct gct ggc acc agt gct act gct gct tct gcc aca gca tct 1200 Thr Thr Ala Ala Gly Thr Ser Ala Thr Ala Ala Ser Ala Thr Ala Ser 385 390 395 400 ggc cca ggc tct ggc tct gcc cca gag gct ggc cct gcc cct ggt ttc 1248 Gly Pro Gly Ser Gly Ser Ala Pro Glu Ala Gly Pro Ala Pro Gly Phe 405 410 415 ccc ttc cct cct ccc tgg atg ggt atg ccc ctg cct cca ccc ttt gcc 1296 Pro Phe Pro Pro Pro Trp Met Gly Met Pro Leu Pro Pro Pro Phe Ala 420 425 430 ttc ccc cca atg cct gtg ccc cct gcg ggc ttt gct ggg ctg acc cca 1344 Phe Pro Pro Met Pro Val Pro Pro Ala Gly Phe Ala Gly Leu Thr Pro 435 440 445 gag gag cta cga gct ctg gag ggc cat gag cgg cag cac ctg gag gcc 1392 Glu Glu Leu Arg Ala Leu Glu Gly His Glu Arg Gln His Leu Glu Ala 450 455 460 cgg ctg cag agc ctg cgt aac atc cac aca ctg ctg gac gcc gcc atg 1440 Arg Leu Gln Ser Leu Arg Asn Ile His Thr Leu Leu Asp Ala Ala Met 465 470 475 480 ctg cag atc aac cag tac ctc acc gtg ctg gcc tcc ttg ggg ccc ccc 1488 Leu Gln Ile Asn Gln Tyr Leu Thr Val Leu Ala Ser Leu Gly Pro Pro 485 490 495 cgg cct gcc act tca gtc aac tcc act gag gag act gcc act aca gtt 1536 Arg Pro Ala Thr Ser Val Asn Ser Thr Glu Glu Thr Ala Thr Thr Val 500 505 510 gtt gct gct gcc tcc tcc acc agc atc cct agc tca gag gcc acg acc 1584 Val Ala Ala Ala Ser Ser Thr Ser Ile Pro Ser Ser Glu Ala Thr Thr 515 520 525 cca acc cca gga gcc tcc cca cca gcc cct gaa atg gaa agg cct cca 1632 Pro Thr Pro Gly Ala Ser Pro Pro Ala Pro Glu Met Glu Arg Pro Pro 530 535 540 gct cct gag tca gtg ggc aca gag gag atg cct gag gat gga gag ccc 1680 Ala Pro Glu Ser Val Gly Thr Glu Glu Met Pro Glu Asp Gly Glu Pro 545 550 555 560 gat gca gca gag ctc cgc cgg cgc cgc ctg cag aag ctg gag tct cct 1728 Asp Ala Ala Glu Leu Arg Arg Arg Arg Leu Gln Lys Leu Glu Ser Pro 565 570 575 gtt gcc cac tgacactgcc ccagcccagc cccagcctct gctcttttga 1777 Val Ala His gcagccctcg ctggaacatg tcctgccacc aagtgccagc tccctctctg tctgcaccag 1837 ggagtagtac ccccagctct gagaaagagg cggcatcccc taggccaagt ggaaagaggc 1897 tggggttccc atttgactcc agtcccaggc agccatgggg atctcgggtc agttccagcc 1957 ttcctctcca actcttcagc cctgtgttct gctggggcca tgaaggcaga aggtttagcc 2017 tctgagaagc cctcttcttc ccccacccct ttccaggaga aggggctgcc cctccaagcc 2077 ctacttgtat gtgcggagtc acactgcagt gccgaacagt attagctccc gttcccaagt 2137 gtggactcca gaggggctgg aggcaagcta tgaacttgct cgctggccca cccctaagac 2197 tggtacccat ttccttttct taccctgatc tccccagaag cctcttgtgg tggtggctgt 2257 gccccctatg ccctgtggca tttctgcgtc ttactggcaa ccacacaact cagggaaagg 2317 aatgcctggg agtgggggtg caggcgggca gcactgaggg accctgcccc gcccctcccc 2377 ccaggcccct ttcccctgca gcttctcaag tgagactgac ctgtctcacc cagcagccac 2437 tgcccagccg cactccaggc aagggccagt gcgcctgctc ctgaccactg caatcccagc 2497 gcccaaggaa ggccacttct caactggcag aacttctgaa gtttagaatt ggaattactt 2557 ccttactagt gtcttttggc ttaaattttg tcttttgaag ttgaatgctt aatcccggga 2617 aagaggaaca ggagtgccag actcctggtc tttccagttt agaaaaggct ctgtgccaag 2677 gagggaccac aggagctggg acctgcctgc ccctgtcttt tccccttggt tttgtgttac 2737 aagagttgtt ggagacagtt tcagatgatt atttaatttg taaatattgt acaaatttta 2797 atagcttaaa ttgtatatac agccaaataa aaacttgcat taac 2841 <210> 35 <211> 3536 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (31)..(1518) <400> 35 cccgtggggg gctcatccta cccacagtaa gag cat cct ggc gtg acc cca ctg 54 Glu His Pro Gly Val Thr Pro Leu 1 5 agg act tca cct cct ctc cct tgg tgg aca cct atc cag gtg ggc atc 102 Arg Thr Ser Pro Pro Leu Pro Trp Trp Thr Pro Ile Gln Val Gly Ile 10 15 20 gtg ctg cac tat tct aca ctg tcc acc atg ctg tgg ata gga gtg acc 150 Val Leu His Tyr Ser Thr Leu Ser Thr Met Leu Trp Ile Gly Val Thr 25 30 35 40 gcc agg aac atc tac aag cag gtg acc aag aag gcc cct ctg tgc ctg 198 Ala Arg Asn Ile Tyr Lys Gln Val Thr Lys Lys Ala Pro Leu Cys Leu 45 50 55 gac aca gac cag cca ccg tac ccc agg cag ccc ctg ctc agg ttt tac 246 Asp Thr Asp Gln Pro Pro Tyr Pro Arg Gln Pro Leu Leu Arg Phe Tyr 60 65 70 ctc gtc agc gga ggg gtc ccc ttt atc atc tgt ggg gtc acg gct gcc 294 Leu Val Ser Gly Gly Val Pro Phe Ile Ile Cys Gly Val Thr Ala Ala 75 80 85 acg aac atc agg aat tac ggg aca gag gac gag gac acg gcg tac tgc 342 Thr Asn Ile Arg Asn Tyr Gly Thr Glu Asp Glu Asp Thr Ala Tyr Cys 90 95 100 tgg atg gcc tgg gag ccc agc ctg ggc gcc ttc tac ggc cca gcc gcc 390 Trp Met Ala Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro Ala Ala 105 110 115 120 atc atc acc ctg gtc acc tgt gtg tac ttc ctg ggc acc tac gtg cag 438 Ile Ile Thr Leu Val Thr Cys Val Tyr Phe Leu Gly Thr Tyr Val Gln 125 130 135 ctg cgg cgc cac cca ggg cgc agg tac gag ctg cgc aca cag ccc gag 486 Leu Arg Arg His Pro Gly Arg Arg Tyr Glu Leu Arg Thr Gln Pro Glu 140 145 150 gag cag cgg cgg ctg gcg aca ccc gag ggc ggc cgt ggg atc cgg cca 534 Glu Gln Arg Arg Leu Ala Thr Pro Glu Gly Gly Arg Gly Ile Arg Pro 155 160 165 ggc acc cca ccc gca cac gat gcc ccc ggc gcc tcc gtg ctg cag aac 582 Gly Thr Pro Pro Ala His Asp Ala Pro Gly Ala Ser Val Leu Gln Asn 170 175 180 gag cac tca ttc cag gca cag ctg cgc gcc gcc gcc ttc acg ctg ttc 630 Glu His Ser Phe Gln Ala Gln Leu Arg Ala Ala Ala Phe Thr Leu Phe 185 190 195 200 ctg ttc acg gcc acg tgg gcc ttc ggg gcg ctg gcg gtg tca cag ggc 678 Leu Phe Thr Ala Thr Trp Ala Phe Gly Ala Leu Ala Val Ser Gln Gly 205 210 215 cac ttc ctg gac atg gtc ttc agc tgc ctg tac ggc gcc ttc tgc gtg 726 His Phe Leu Asp Met Val Phe Ser Cys Leu Tyr Gly Ala Phe Cys Val 220 225 230 acc ctg gga ctc ttc gtg ctc atc cac cac tgc gcc aag cgt gag gac 774 Thr Leu Gly Leu Phe Val Leu Ile His His Cys Ala Lys Arg Glu Asp 235 240 245 gtg tgg cag tgc tgg tgg gca tgc tgc ccg ccc cgc aag gac gcc cac 822 Val Trp Gln Cys Trp Trp Ala Cys Cys Pro Pro Arg Lys Asp Ala His 250 255 260 ccc gca ctt gac gcc aac ggg gcc gcg ctg ggc cgc gcc gcc tgc ctg 870 Pro Ala Leu Asp Ala Asn Gly Ala Ala Leu Gly Arg Ala Ala Cys Leu 265 270 275 280 cac tcg ccg gga ctg ggc cag cca cgg ggc ttc gcg cac cca ccg ggc 918 His Ser Pro Gly Leu Gly Gln Pro Arg Gly Phe Ala His Pro Pro Gly 285 290 295 ccc tgc aag atg acc aac ctg cag gcc gcg cag ggc cac gcc agt tgc 966 Pro Cys Lys Met Thr Asn Leu Gln Ala Ala Gln Gly His Ala Ser Cys 300 305 310 ctg tca ccg gcc acc ccg tgc tgc gcc aag atg cac tgc gag cca ctg 1014 Leu Ser Pro Ala Thr Pro Cys Cys Ala Lys Met His Cys Glu Pro Leu 315 320 325 acg gcg gac gag gcg cac gtg cac ctg cag gag gag ggc gcc ttc ggg 1062 Thr Ala Asp Glu Ala His Val His Leu Gln Glu Glu Gly Ala Phe Gly 330 335 340 cac gac ccc cac ctg cac ggg tgc ctt cag ggc aga act aag ccg ccc 1110 His Asp Pro His Leu His Gly Cys Leu Gln Gly Arg Thr Lys Pro Pro 345 350 355 360 tac ttt agc cgg cac cca gca gag gag ccc gag tac gcc tac cac atc 1158 Tyr Phe Ser Arg His Pro Ala Glu Glu Pro Glu Tyr Ala Tyr His Ile 365 370 375 cca tcc agc ctg gat ggc agc ccc cgc agc tcg cgc aca gac agc ccc 1206 Pro Ser Ser Leu Asp Gly Ser Pro Arg Ser Ser Arg Thr Asp Ser Pro 380 385 390 ccc agc tct ctg gat ggc ccg gcg ggg aca cac acg ctg gcc tgc tgc 1254 Pro Ser Ser Leu Asp Gly Pro Ala Gly Thr His Thr Leu Ala Cys Cys 395 400 405 acc cag ggc gac ccc ttc ccc atg gtc acc cag ccc gag ggc agt gat 1302 Thr Gln Gly Asp Pro Phe Pro Met Val Thr Gln Pro Glu Gly Ser Asp 410 415 420 ggg agc cct gcc ctc tac agc tgc ccc acg cag ccg ggc agg gag gca 1350 Gly Ser Pro Ala Leu Tyr Ser Cys Pro Thr Gln Pro Gly Arg Glu Ala 425 430 435 440 gcg ctc ggg ccc ggc cac ttg gag atg ctg cgg agg aca cag tcc ctg 1398 Ala Leu Gly Pro Gly His Leu Glu Met Leu Arg Arg Thr Gln Ser Leu 445 450 455 ccc ttt ggt ggc ccc agc cag aac ggg ctg ccc aag ggt aaa ttg cta 1446 Pro Phe Gly Gly Pro Ser Gln Asn Gly Leu Pro Lys Gly Lys Leu Leu 460 465 470 gaa ggc ctg ccg ttt ggc acc gac ggg acc ggc aac atc cga acg gga 1494 Glu Gly Leu Pro Phe Gly Thr Asp Gly Thr Gly Asn Ile Arg Thr Gly 475 480 485 ccc tgg aaa aac gaa act act gtg tagatggggg cagaggacac ggtgttcctg 1548 Pro Trp Lys Asn Glu Thr Thr Val 490 495 gaggagcttc agagcagagt ggggggccca tctgccacat gaggtcactg ggggtaccga 1608 agtgaccccg cctttcagaa gccgttcaca cccctgcccc ttccttgtga tcacacccct 1668 gccccttcct tgtgatcaca cccctgcccc ttccttgtgt tcacacccct gccccttcct 1728 tgtgatcaca cccctgcccc ttccttgtga tcacacccct gccccttcct tgtgttcaca 1788 cccctgcccc ttccttgtga tcacacccct gccccttcct tgtgaaagac ctcagcgggg 1848 aaacgctccg ggccacgccc actcccctta tcccaattcc gcgtgctggt cccgcacacg 1908 gtcatccggt ttctgtcctg tgatctccag tcctggggca ccctagaggc agagcagggg 1968 attccatcaa aggacccact gagaccccag catggccctg cccgagatgc cctgctgccc 2028 acggagtcct ggcttcccct ggtgtggccg ggcagggccg agatcgcagg agggggctgc 2088 cctgaccttt cccagtgttc aatgtgtgtg tcttgcgttc tactccgggg gtggcggcgg 2148 caggtctgtc cccagcattc tcgctctggg cagaaccctc gggaccctcc gctgtcgtgt 2208 gtctgagcca cccctgcagc ttcacagggc ccctgcacac ctctgcccac tcagtgtgcc 2268 ctgtcagccc tgtccttgtc gtagccccag ccctgcaggg ctgagagcac cacagatgct 2328 gggggctgct ctggactttg gggatggctg tcagcctcag agggccaatg gggggctttc 2388 acgggcccaa ggcttgggaa aatgcccaga catcctttag tgaagactcg acttccaaaa 2448 ccagccaccg ctgggactgg attccactcc agtataggca cttagcaaca cgaaggttta 2508 ttccaaaaag aaaaggggct gacagacggg agattctcat ggacaaaatc cctttccctt 2568 tttctcgtct ccatgaacat ctgggtacca agccctgact caaaggacag atgtggatga 2628 cagcaagact tctgtgaaag caagtggccc gtccctaggt gggagggagt ccagagggtc 2688 atgggtgtga aactgtgcac agctttccct ccctccctct tcctccttgt ctgtgacaca 2748 tgtgcacaca cacacacaca caaacacatg tgcatatcac acacatgcac acacacaaac 2808 acatgtgcat atcacacacg cgcacacacc caaacacgtg catatcacac acatgcacac 2868 acacaaacac gtgcatatca cacacatgca cacaaacgtg catatcacac acacgcacac 2928 acacccaaac acgtgcatat cacacacacg cacacacaca aacacgtgca tatcacacac 2988 aaacacacgt gcacacatac ttaacacaca cttgcacctg ctatgcacat gtgcacacac 3048 acgtagtagt gtgttttcca gccacccaca cactgggttt gcattggaga ttgtttcacc 3108 ctgcaaacgt caacgtcagc agactcgtcg gtgcgctgtg ctatccggtt gggaggtctc 3168 accaggagca gagcctccct aacgtgcacc tccgagaaga ggggtgtcgg ggagtgttcc 3228 cagcacctgc tcggtggaag ggctctccgg agactggcac tcagtatctg agtatgagga 3288 gcctcacttc ccggggtgtc ggtaaacttg accgtgactc agtaacccac agcgtgctcc 3348 tcccagcaaa ccccgtgtgt ccttacaggt cgaccagacg ggccgtcgga ggaccaccag 3408 gtggctctgc ctctgcctca ccttctcacc tgcttccata gctgatgtga acccgaatcc 3468 ccacgctgtg ctgtgtacgc actgtaggtg cagaaccgtc cacacaaaaa tacagtcttg 3528 gcattgtt 3536 <210> 36 <211> 6899 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(806) <400> 36 ag aac gca ggt gga ggg gga ttg gag aat gca ctc agt aag gga agg 47 Asn Ala Gly Gly Gly Gly Leu Glu Asn Ala Leu Ser Lys Gly Arg 1 5 10 15 gag aaa tgt agc gct gga tcg cag aaa gca ggc agc ggg gaa ggt cct 95 Glu Lys Cys Ser Ala Gly Ser Gln Lys Ala Gly Ser Gly Glu Gly Pro 20 25 30 ggg aaa gct ggc agc gag ggt ttg cag cag gtt gtc ggc atg aag aaa 143 Gly Lys Ala Gly Ser Glu Gly Leu Gln Gln Val Val Gly Met Lys Lys 35 40 45 tca ggt ggt ggc gac tca gag cgg gcc gct gcg tta agc ccg gag gac 191 Ser Gly Gly Gly Asp Ser Glu Arg Ala Ala Ala Leu Ser Pro Glu Asp 50 55 60 gag acg tgg gag gtg ctg gag gag gcg ccg ccg cca gtg ttc ccc ctg 239 Glu Thr Trp Glu Val Leu Glu Glu Ala Pro Pro Pro Val Phe Pro Leu 65 70 75 cgg cct ggc gga ctc cca ggg cta tgc gaa tgg ctg cgg cga gcg ctc 287 Arg Pro Gly Gly Leu Pro Gly Leu Cys Glu Trp Leu Arg Arg Ala Leu 80 85 90 95 ccc cca gcc cag gca ggg gca ctg ctg ctg gcg ttg cca cca gca tct 335 Pro Pro Ala Gln Ala Gly Ala Leu Leu Leu Ala Leu Pro Pro Ala Ser 100 105 110 ccc agc gct gcc cga acc aag gct gcg gcg ttg cga gcc ggg gcg tgg 383 Pro Ser Ala Ala Arg Thr Lys Ala Ala Ala Leu Arg Ala Gly Ala Trp 115 120 125 agg cca gct ctg ctg gct agt ctg gcg gcg gcg gcg gca cca ctc cca 431 Arg Pro Ala Leu Leu Ala Ser Leu Ala Ala Ala Ala Ala Pro Leu Pro 130 135 140 ggg ctg ggc tgg gca tgc gac gtg gca ctt ctg cgg ggt cag ctg gcg 479 Gly Leu Gly Trp Ala Cys Asp Val Ala Leu Leu Arg Gly Gln Leu Ala 145 150 155 gag tgg cga cgg ggc ctg ggg ctg gaa ccc acg gca ctg gct cga cgt 527 Glu Trp Arg Arg Gly Leu Gly Leu Glu Pro Thr Ala Leu Ala Arg Arg 160 165 170 175 gag cgt gcc ctg ggc ctg gct tct gga gag ctg gca gcg cgc gct cat 575 Glu Arg Ala Leu Gly Leu Ala Ser Gly Glu Leu Ala Ala Arg Ala His 180 185 190 ttc cca ggc ccg gtg acg cgc gcc gag gtg gaa gca aga ctg ggc gcc 623 Phe Pro Gly Pro Val Thr Arg Ala Glu Val Glu Ala Arg Leu Gly Ala 195 200 205 tgg gcg ggc gag ggc act gct ggg ggc gca gca ctg ggg gct ctc tcc 671 Trp Ala Gly Glu Gly Thr Ala Gly Gly Ala Ala Leu Gly Ala Leu Ser 210 215 220 ttc ctg tgg cct gcg ggt ggt gca gcg gcg aca ggt ggc ctg ggc tac 719 Phe Leu Trp Pro Ala Gly Gly Ala Ala Ala Thr Gly Gly Leu Gly Tyr 225 230 235 cga gcg gct cac ggc gtc ctg ctg cag gct ctc gat gag atg cgg gct 767 Arg Ala Ala His Gly Val Leu Leu Gln Ala Leu Asp Glu Met Arg Ala 240 245 250 255 gat gct gag gct gtg ctg gca ccc cct gag cct gcc cag tgaggagtgg 816 Asp Ala Glu Ala Val Leu Ala Pro Pro Glu Pro Ala Gln 260 265 gagggggctt gggagtccag actctgacag gggatgcctg ggcttaatcc tgggtgcttg 876 aaggggatgt ggactcttga cttccagctg ggatgtgtga cttcttatca cctggattca 936 gagagtctgg gggacaggaa tcctgatttt tttttttttt tttttctttt ttttgtgaga 996 cgaagtctct tgttgcccag gctggagtgc aatggcgcga cctcggctca ctgcaacctc 1056 cgcctcccgg gttcaagcga ttctcctgcc tcagcgtccg gagtagctgg gattacaggt 1116 gcctgccacc acacctggct aatttttgta tttttagtag agacggggtt tcaccatgtt 1176 ggccaggctg gcctcgaact cctgacctca ggcgatcgac ccgctccggc ctcccaaagt 1236 gctaggatta caggcgtgag ccaccgcccc tggccaggaa tcctgatacc tttgggaacc 1296 atggtgaatg acatctagac ccttctgtcc tgaagggagt tggtggccca gactctagca 1356 gggactatgt ctttgtctcc tagggagtag aaactggagt tactggatgt ttagtcctcc 1416 agggaggctg gtagaagtcc tgtttcctaa ttggtgggga ggtgtccatg actgggacct 1476 gaactccagt ataggggagg gagacctgag cgccccaggg agctggaact cttgggcttc 1536 agagcctcag agggaaacag ggtctacatt tctctgggag aaaaagcctg cacacaggtc 1596 cccaaggagc agtgggcttt gaatcttgat ggggtggcgg aggcccctgg ggtctgagac 1656 ttccggggtt ctaagatggc tgtggacctt ggttcctaaa tattgggtaa ggggaggtct 1716 gcatctggag gagggatcgg gggcttgtgc gagaaagctg gagacttctt gatctctcct 1776 ggggagtgga tgggtttcta taattgccct ccaaaagcat gtagggaggg tggtcccaca 1836 aaaatgaggt gaggtgggta agaggtctgg gcatggtggg ctctgggagt agccagggac 1896 caggaatgag gtcttttggg tgtggaaggg cagtaaagca tacctcagag acagctcctc 1956 caaaccttgt attgggatcc cggcaactgc ctctgtgagt gtgactggga agggatatga 2016 ctgccttcat cttctaggtg ctgagcaatt caggtgatct ctggggagtc tgtttctctg 2076 tctcttttct ttaggagttt ctatcttttt ttggcctttt tctcctggta tttaaccata 2136 accctttatg gccttggtgt tttgtgcacc ttccttttca gaagagcagc tgtactgctg 2196 cactggtcca aacacttctg tatggacacc tcgggtatcc ccaagaggct ctgctttctg 2256 atgtacatag agggtgctgc attgagccag gggcccacca aatgggtggt caggcacttg 2316 agaccatggg aatatgccag gagtgaatga agcaaaggca gaaaccacag tgcctggaat 2376 gttctaggct gctagccaca tgtgggggaa aagttgcagg ttacagaatt cttcagtgtc 2436 aaaaacagaa aaggaggatc tgagaatcca agcgatagaa tcccttttgt cgtagacaga 2496 aagagcaaag tccagagagg gcaggcttga ggcccaacag cacacagtaa ggccctgtgg 2556 gtctggccct tgcctattct cattcactgc cccttcccac tcctgtccag cctgatagac 2616 tttccttctt tttttttttg aaatggagtc tcaccttgtc acccagtctg gagtacaggg 2676 atgtgatgac tgtagctgag atgacaggca tgtgccacca cacctggcta atttttgtag 2736 tttagtagag aagggatttc accctgttgg tcaggctggt ctcgaactcc tgacctcagg 2796 tgatccaccc gactcagact cccaaagtgc tgggattaca ggtgtgagcc atcatggccg 2856 cctgactctt tctgatgcct gagtggctac cttgagtcct gcctggggac ccatgcacct 2916 gctgttctct ttccttcaag gctctactca caacttcctg ttctactctc aaaccttcct 2976 gtgacgggct cagtcagatc tcagctcacg tatcccctca gagaggactt cccctccctg 3036 accaccctat ctgaagtagc tcacattccc ccactattca tttcggccag ttgagtttcc 3096 ttgtagcaat tattactgtc aaaaatgatc ttatttattt acctgtttat tggcttttga 3156 cccgttgcct gtcctgttct ctgttgtttc cccagcatct agaacaatag gtgcctgaca 3216 caataggtgc ttcgtaaata tttattatta ttattattat tttagagaca gggtcttgct 3276 ctgttgcccc ggctggaata cagtgggatg atcatggctc actgccatct ccaactcctg 3336 ggctcaaacg atcctcccac ctccgcctac agagtagctg ggactatagg tacacagcac 3396 caaattttct gtagagacgg gggtcttgct ttgtagccca cactagtgtt gaactcctgg 3456 cctcaagtga tcctcctgcc ttgatgggat tacaggtgtg agccaccaca cccagcctaa 3516 atgtttattt cattggtcag tgtcagaact aggattggaa tttagattgt taatctcttg 3576 ccacaagata ggaaaatgga gcaagatgag gagaaaaaag catttaatgg gagagaacac 3636 ccttgtctga ggtcagggac ctgggaagca agcacgactt tgccactgtc actgtgtgtt 3696 acttggacag tgccttattt tcccatctgt gaaataaaag agctggataa gaaccttagt 3756 tttgagatcc tgtctccctt aaaagctgaa gacaaaggta actgatccaa gggcagacaa 3816 gggatggtac catcatctcc agcttggact cccactgctg acaaaatttg tcccttcaaa 3876 gttgagatag ctaccatggg gaagagcact tagttctata ctgaatggct ccaggcattt 3936 tcatgaaagc tctttcagct ttggggaaga atattcatcc atatctttac cccatcatat 3996 tagtgtctaa gccctgcaat caggcatgtc agccacgtga tggaatggga gggctgcagg 4056 gcagcactgt ccagtagaaa cgaaatgcaa gccacatatg tcattttaag ttttcttttt 4116 ttgagatgga gtttcactcc atcacccagg ctggagtgca gtggcacgat ctcgcctcac 4176 tgcaacctcc gcctcccagg ttcatgtgat tctcctgcct cagcctcctg agtagctggg 4236 attacaggca tatgccacca tgcctggcta atttttgtat ttttagtaga gatggggttt 4296 caccatgttg atcaggctgg tctggaacta ctgacctcag gccacccgcc ttggcctccc 4356 aaagtgctgg gattacaggc atgagccacc gcgcccagct aatttttgta tttttatttt 4416 atttatttat ttattttttg ggagacggag tcttgctctg tcacccaggc tggagtgcag 4476 ttgtgcgatc ttggctcact gcaacctcag cctcccaagt agctgggatt acaggcatgc 4536 accatcatgc ccagctaatt tttgtatttt tagtagagat ggggtttcac tgtgttggcc 4596 aggctggtct tgaactcctg acctcaggtg atccaccggc ctcagcctcc caaagtgctg 4656 ggattatagg cgtgagccac tgcacccgtc ctaatttttg tatttttagt agagatgggg 4716 tttcaccatg ttggctaagc tggtctggaa ctcatggcct caagttatct gcccacctca 4776 gcctcccaaa gtgctgagta agccaagttt tctaatagcc acattagaca agtaaaagga 4836 aacaggttaa attcatttta acatgtttta cttaacccaa tgtatccaaa atagcatttc 4896 aacatgtcat cggtttttta gttttttttt tttttgagat agtgcttcgc tttgttgccc 4956 aggctggagt gcagtggcac aatctcggct cactgcaacc tccaccttcc aggttcaagt 5016 gattctcctg cctcagcctc ccgagtagct gggattacag gcacccgcca ccatgcccac 5076 taatttttgt atttttggtt agagatgggg tttcgccatg ttggccaggc tagtctcaaa 5136 ctcctgacct caggtgatcc acccacctcg gcctcccaaa gtgctaggat tacaggcgtg 5196 aggcaccgtg cctggcgtca tcggtattat ttaaatgaat tatgttacgt tcttttgtgc 5256 tgtcttcaaa atctgttata tattttacac ttacaccaaa tctcaattac catggtacat 5316 ttttatctga aatgcttgac ctttattttg atttcataaa attcatagtt ggagaagtag 5376 attcacatat ccaagttgtt ccaattatat aatagttttc caaaaactga gatgggtgtc 5436 catttttttt ttaagtaaag atgcaggtct ggttatgttg accaagttgc tgggttgttt 5496 tgttttgttt tgagacagag tctcactttg tcacccaggc tggagtgcag tggcatgacc 5556 tcagctcact gcaacctctg cctcccaggt tcaactgatt ctcttgcatc atcctcctga 5616 gtagctggga ctacaggtgt atgccaccat gcctggctaa ttttggtatt tttctcagag 5676 acggggtttc accatgttgg gcatgctggt cttgaactgc tgacctcagg tgatccgccc 5736 acctcggcct cccaaagtgc tggtattaca ggcatgggcc accacacctg gcctcagctg 5796 ttcaattaaa agtaaataca acttaaaatt ctatgtttca ttggcagtag tgcaacatta 5856 atactgagta gccacatgtg ttagtggcta tggtattgga cagggaaggt acagaatact 5916 tccatcaaca tagaaaattc tatcagtcta gctctagggg cagatagtcc ttccactgac 5976 ttgggcaagt cactctacaa atggcatcta cctcacatgg ttatggtgag aattcagcgt 6036 atgtatgtac atgcaggcac acaatatgca cacagacaca taacatagta caccctttcc 6096 tgaaaagcct gacacatgga gctcaaacat gagtgccacc cacccctggg cagcaccaag 6156 atggctctag tctgggtgcc tttgtctcac ccccatgcct ttgctcggag tgtgctcctc 6216 atttttctgc cactttgacc ctgtctctga tttggtcctg tctgacatca ctgctatatg 6276 ctttgctcct ctcaatttcc tctgccctca tgccagcagg agtcatgcca gagatcatat 6336 ctgagaaagc aagacaattt tgtgtgtgtg tctgtgccca tagaggagtg ctggttgtgt 6396 tgatatagtt gtagattggt tgtgtttaca cagttgtata tattgacacc cttgagtgtt 6456 atgacttctt ttgggggtgg tcgcctttta aatcataact tttaatggga ttccatttta 6516 gtctttgtga agacataagg ttgttggcag gcatctgtcc ctgggagcat ccaagcagaa 6576 aagactaaga ctcccttgta gacagatcac tggccgccac tgaagtgtgt ctgcatggca 6636 ccacagggct ggaagaccct tgaaggcagg aattcaagga aatgtatgat gaattttggc 6696 attgccatca aaagcagaac aggcatggaa aacttgggtg agtgggcgag acaacctcct 6756 caccacagca gagttccatc catgcctgga taatgaggga gggatttgtg tccactgcag 6816 tggggaacca tgaaggacac atcaagggtg tggttggcct gtggtgctct ttggaggaat 6876 gaataaaaat gaatagaaat cct 6899 <210> 37 <211> 3375 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(1141) <400> 37 g cgg ccg ctt ccc ggg tac ccc gac gcc gag gcc ccg gag cct tcc tcc 49 Arg Pro Leu Pro Gly Tyr Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser 1 5 10 15 gct ggg gct cag gca gcg gag gag ccg tcg ggg gcc ggc tca gaa gag 97 Ala Gly Ala Gln Ala Ala Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu 20 25 30 ctg atc aag tcg gac cag gtg aac ggc gtg ctg gtg ctg agc ctc ctg 145 Leu Ile Lys Ser Asp Gln Val Asn Gly Val Leu Val Leu Ser Leu Leu 35 40 45 gac aaa atc atc ggg gcc gta gac cag atc cag ctg act caa gca cag 193 Asp Lys Ile Ile Gly Ala Val Asp Gln Ile Gln Leu Thr Gln Ala Gln 50 55 60 ctg gag gag cgg cag gcg gag atg gag ggc gca gtg cag agc atc cag 241 Leu Glu Glu Arg Gln Ala Glu Met Glu Gly Ala Val Gln Ser Ile Gln 65 70 75 80 ggc gag ctg agc aag ctg ggc aag gcg cac gcc acc acg agc aat acg 289 Gly Glu Leu Ser Lys Leu Gly Lys Ala His Ala Thr Thr Ser Asn Thr 85 90 95 gtg agc aag ctg ctg gag aag gtg cgc aag gtc agc gtc aac gtg aag 337 Val Ser Lys Leu Leu Glu Lys Val Arg Lys Val Ser Val Asn Val Lys 100 105 110 acc gtg cgc ggc agc ctg gag cgc cag gcg ggg cag atc aag aag ctg 385 Thr Val Arg Gly Ser Leu Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu 115 120 125 gag gtc aac gag gcc gag ctg ctg cgg cgc cgc aac ttt aaa gtc atg 433 Glu Val Asn Glu Ala Glu Leu Leu Arg Arg Arg Asn Phe Lys Val Met 130 135 140 atc tac cag gat gaa gtg aag ctg ccg gcc aaa ctg agc atc agc aaa 481 Ile Tyr Gln Asp Glu Val Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys 145 150 155 160 tcg ctg aaa gag tcg gag gcg ctg cca gag aag gag ggc gag gag ctg 529 Ser Leu Lys Glu Ser Glu Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu 165 170 175 ggc gag ggc gag cgg ccc gag gag gac gca gcg gcg ctg gag ctt tcg 577 Gly Glu Gly Glu Arg Pro Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser 180 185 190 tcg gac gag gcg gtg gag gtt gag gag gtt att gag gag tcc cgc gca 625 Ser Asp Glu Ala Val Glu Val Glu Glu Val Ile Glu Glu Ser Arg Ala 195 200 205 gag cgt atc aag cgc agc ggc ctg cgg cgc gtg gac gac ttc aag aag 673 Glu Arg Ile Lys Arg Ser Gly Leu Arg Arg Val Asp Asp Phe Lys Lys 210 215 220 gcc ttc tcc aag gag aag atg gag aag acc aag gtg cgt acc cgc gag 721 Ala Phe Ser Lys Glu Lys Met Glu Lys Thr Lys Val Arg Thr Arg Glu 225 230 235 240 aac ctg gag aag acg cgc ctc aag acc aag gaa aac ctg gag aag acg 769 Asn Leu Glu Lys Thr Arg Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr 245 250 255 cgg cac acc ctg gag aag cgc atg aac aag ctg ggc acg cgc ctg gtg 817 Arg His Thr Leu Glu Lys Arg Met Asn Lys Leu Gly Thr Arg Leu Val 260 265 270 ccc gcc gag cgg cgc gag aaa ctg aag acg tcg cgg gac aag ttg cgc 865 Pro Ala Glu Arg Arg Glu Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg 275 280 285 aaa tcc ttc acg ccc gac cac gtg gtg tac gcg cgc tcc aag acc gcg 913 Lys Ser Phe Thr Pro Asp His Val Val Tyr Ala Arg Ser Lys Thr Ala 290 295 300 gtc tac aag gtg cca ccc ttc acc ttc cac gtc aag aag atc cgc gag 961 Val Tyr Lys Val Pro Pro Phe Thr Phe His Val Lys Lys Ile Arg Glu 305 310 315 320 ggc cag gtg gaa gtg ctc aag gcc acc gag atg gtg gag gtg ggc gcc 1009 Gly Gln Val Glu Val Leu Lys Ala Thr Glu Met Val Glu Val Gly Ala 325 330 335 gac gac gac gag ggc ggc gcg gag cgc ggg gag gcc ggc gac ctg cgg 1057 Asp Asp Asp Glu Gly Gly Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg 340 345 350 cgc ggg agc agc ccc gac gtg cac gcg ctg ctg gag atc acc gag gag 1105 Arg Gly Ser Ser Pro Asp Val His Ala Leu Leu Glu Ile Thr Glu Glu 355 360 365 tcg gac gcc gtg ctg gtg gac aag agc gac agc gac tgagccgccc 1151 Ser Asp Ala Val Leu Val Asp Lys Ser Asp Ser Asp 370 375 380 ccgctgccac ccaccccatt cctcgctcct tccgaacttc ctctttcgca ttctctctcg 1211 gctcgagctg gctgagattt ttctaaattg aaaacacgcc cccctcccca cacctccagg 1271 aactccactc ccagtcttag agctgttagg acccgatggg gaggcagccc ccgcagtgga 1331 cagcccccgc ttggacacag tccgagtgga atgggaaggg aatggtcaat ccctgtcctg 1391 gttgtccaag tcgggatctc agaggaaatt gcagtgattc cacggttagg cccccctggg 1451 ggggctgcct tcccctcagc ctctccccac accacccacc cagctgctgt cattccgctc 1511 actgagctct tcttcattct caccctgatc cctgggggac tcaaagccaa aactgcccaa 1571 agaggaaaga ttgaatccta aaggggatcc ttgcccccat gggaggcccc ctactagaag 1631 gacgtgaaag cagcttttgg gggaaactga ggcagtgggg aagacagagc agaatgagcc 1691 ctcaccctgg ctgggggtcc agcacaggct gtatctgcag agggtcccag aggaacgctg 1751 gagccaagag aagccctggg aaggaggggt ggggaacgac atgcatgtga gggatggcac 1811 actgatgtgt ttatgcacct gtacacagga gcgcatggcc atggctttgg aaaggagaat 1871 ggaaaaatag aagaaggtcg gccgggcttg gtggcttaag cctgtaaccc cagcactttg 1931 ggaggccgag gtgggcggat cacctgaggt caggagttcg ggaccagcct ggcaaacacc 1991 ccatctctac taagcgaaaa cccatctcta ctaaaattac aaaaattagc tgggcatggt 2051 tgcgcatgcc tgtaatccca gctactttgg aggctgaggt ggggagaatt gcttgaacct 2111 gggaggtgga ggttgcagtg agccaaggtc gcgacactgc actccagcct gggtgacaga 2171 gtgagactcc atctcaacag aaggaaaaaa aaggaaaata ggagaaggtg gaaatgggtg 2231 aagagagaag tcccctcact agctgcatga gaaatctatc ttactgtggt tctccatggg 2291 cagcaggacc atttttcaga atcaagaggg aggacagtgt gagaaggcga tgatccaaag 2351 aagacagaga ggtcagcccc acccgatccc tcaaatgggc tcttggaggc acccccaggg 2411 gcagcccatt tctcaaagtc cagaaaatta gggtcccaga agggggcagc agcaggctgg 2471 gagttaggag ggagagcagg gtgccggccc tgccaccaag ttgagagctg gaggggaggt 2531 ggggagagaa catcacagag cagccagccc tggttcactc ctggcagttt cttctcaagc 2591 tccttcccta ggagcatggt ggcacgtgcc tgtggtctca gctacttggg aggctgaggc 2651 gggaggatcg ccagagccca ggagtttgag gctgcagtga gctatgaggg tgcctctgtg 2711 ctccatccta ggcaacagag tgagacgctg tttaaaaagg aaaaaatcct tccctagagc 2771 tagtatccta aagctgcaga gctagcccag acctcattgg tttccttgtc cttggggtgc 2831 ttttcctgaa tctttggggg tgaagggagt gttgctccca gtccagaggc ctgattctgt 2891 tcggactggg ttctcaagac acgaccaggt tctcaagaca cgagtcccct tgttcctccc 2951 cattaaaggg ggtttgtcag aagcaagaac agcccctctc cccagtcaca gcctgaaggg 3011 aggccccgag agcttcctcc ttccccccac ctgctcctta ccttctctgc cctgcttttt 3071 agaactgcag ttcattgttt taagggattg ggggagggag cctggggaca caaacctttt 3131 atacaataca aagctttgct tttttttttt ttttcttcct tttccctttc tcggttctct 3191 tctctcctct gaatggctga agacccctct gccgagggag gttggggatt gtgggacaag 3251 gtcccttggt gctgatggcc tgaaggggcc tgagctgtgg gcagatgcag ttttctgtgg 3311 gcttggggaa cctctcacgt tgctgtgtcc tggtgagcag cccgaccaat aaacctgctt 3371 ttct 3375 <210> 38 <211> 2812 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (166)..(1236) <400> 38 gcggccgccc ctgtccagcc tcggcgcccg ggaccgagcg cgtcgctcgc cgccgcggag 60 cgcgtagccg gagcgcctgg ggaaggcgga gatgaagacc acgccgccgc gcgccgggag 120 ctgctgagcc taccgccgcc agagtccagt tgacacttac tttga caa agg caa att 177 Gln Arg Gln Ile 1 tgg aag caa tta ctt gag gac agt tca tat agc atc tgg aca gtc aac 225 Trp Lys Gln Leu Leu Glu Asp Ser Ser Tyr Ser Ile Trp Thr Val Asn 5 10 15 20 acg ggc acc atg aag cac ttc ctg aga atg ttg atc cag gta tgc ctg 273 Thr Gly Thr Met Lys His Phe Leu Arg Met Leu Ile Gln Val Cys Leu 25 30 35 tat ttt tac tgt aaa ttt ctg tgg cgc tgc ctg aaa ttt gta atg agg 321 Tyr Phe Tyr Cys Lys Phe Leu Trp Arg Cys Leu Lys Phe Val Met Arg 40 45 50 aag cta act gga aga tgt gaa cta caa cgg atc tgt tat aat acc aag 369 Lys Leu Thr Gly Arg Cys Glu Leu Gln Arg Ile Cys Tyr Asn Thr Lys 55 60 65 ccg gga gct tct aga acc atg aaa atc gaa aca tca ctg agg gat tct 417 Pro Gly Ala Ser Arg Thr Met Lys Ile Glu Thr Ser Leu Arg Asp Ser 70 75 80 aaa agt aag ctg ttg cag act tct gtg agt gtt cac ccc gac gct att 465 Lys Ser Lys Leu Leu Gln Thr Ser Val Ser Val His Pro Asp Ala Ile 85 90 95 100 gaa aaa act ata gaa gat atc atg gaa ctg aaa aaa att aat cct gac 513 Glu Lys Thr Ile Glu Asp Ile Met Glu Leu Lys Lys Ile Asn Pro Asp 105 110 115 gta aat cca cag ctg gga atc tct ctt cag gct tgc ctt ctg caa atc 561 Val Asn Pro Gln Leu Gly Ile Ser Leu Gln Ala Cys Leu Leu Gln Ile 120 125 130 gtt ggg tac agg aac ctt att gca gat gtg gaa aaa ctg cgt aga gag 609 Val Gly Tyr Arg Asn Leu Ile Ala Asp Val Glu Lys Leu Arg Arg Glu 135 140 145 gcc tat gat tct gat aat ccc caa cat gaa gaa atg ctt ttg aag tta 657 Ala Tyr Asp Ser Asp Asn Pro Gln His Glu Glu Met Leu Leu Lys Leu 150 155 160 tgg aaa ttc ttg aag ccc aat act cca ctg gaa tct cgg att tct aag 705 Trp Lys Phe Leu Lys Pro Asn Thr Pro Leu Glu Ser Arg Ile Ser Lys 165 170 175 180 cag tgg tgt gaa att ggt ttc caa ggt gat gat cct aaa aca gac ttt 753 Gln Trp Cys Glu Ile Gly Phe Gln Gly Asp Asp Pro Lys Thr Asp Phe 185 190 195 cga gga atg gga ctt ctg gga ctg tac aat ttg cag tat ttc gcg gaa 801 Arg Gly Met Gly Leu Leu Gly Leu Tyr Asn Leu Gln Tyr Phe Ala Glu 200 205 210 agg gat gcc aca gca gct cag cag gtc ctg tct gac tct ctt cat ccg 849 Arg Asp Ala Thr Ala Ala Gln Gln Val Leu Ser Asp Ser Leu His Pro 215 220 225 aaa tgc agg gat atc act aaa gaa gaa ata agc aaa ttc agc aaa gca 897 Lys Cys Arg Asp Ile Thr Lys Glu Glu Ile Ser Lys Phe Ser Lys Ala 230 235 240 gaa tgg gag aag aaa agg atg gat aag gca att ggg tac tca ttt gca 945 Glu Trp Glu Lys Lys Arg Met Asp Lys Ala Ile Gly Tyr Ser Phe Ala 245 250 255 260 att gtg ggc atc aat ata act gac ctg gca tat aat cta ctg gtc agc 993 Ile Val Gly Ile Asn Ile Thr Asp Leu Ala Tyr Asn Leu Leu Val Ser 265 270 275 gga gct cta aaa acc cat ttc tac aat atc gcc cca gaa gct cca aca 1041 Gly Ala Leu Lys Thr His Phe Tyr Asn Ile Ala Pro Glu Ala Pro Thr 280 285 290 ttg tct cac ttt cag caa aca ttc tgc tat ttg atg cat gaa ttt cat 1089 Leu Ser His Phe Gln Gln Thr Phe Cys Tyr Leu Met His Glu Phe His 295 300 305 aag ttt tgg atc gaa gag gac ccc atg gac ata atg gaa ttt aat cgt 1137 Lys Phe Trp Ile Glu Glu Asp Pro Met Asp Ile Met Glu Phe Asn Arg 310 315 320 gtg agg gag aaa ttc cgc aag agg atc atc aaa cag ctg cag aac cca 1185 Val Arg Glu Lys Phe Arg Lys Arg Ile Ile Lys Gln Leu Gln Asn Pro 325 330 335 340 gac atg gcg ctg tgc cca cat ttt gct gcc tcg gaa ggt tta atc aac 1233 Asp Met Ala Leu Cys Pro His Phe Ala Ala Ser Glu Gly Leu Ile Asn 345 350 355 atg tagttgccca cgccggtttt aatggatacc ctggaacact gcctcattgt 1286 Met cttgttagat ctctgcttag gtcgcagctc acgcattgaa tgcacacagt gattgtatgc 1346 atgccttttg gtacagtgtt ttcatctctt ggtcataatt ccgagatccc cagagaccac 1406 tgtttctgga gtatctgtca tccagtgact gctcatattg tggcattatg cagtgttaca 1466 tcttgccttg atacccaggt atggagagag ttttctattt ttttagactt tttttcctct 1526 ccctcataat tcagcattaa agaattgtat ttctctagct gtattttgta tgtaagaggt 1586 ttagctgaat ctcattctgt gaaagccttt taatttattg aaatgtttca tgactactgc 1646 tgctagctct tcaagccagg ttcatgcttg gacctcattc tgataaagta taagacttta 1706 aaataataca aaacagggcc gggcgcagtg gctcacacct gtaatcccag cactttgggg 1766 agctgaggcg ggcggatcac gaggtcaaga gatcgagacc atcctggcca acatggtgaa 1826 accccgtctc tactaaaaat aacaaaaatt agctgggcgt ggtggtgggt gcctgtaatc 1886 ccagctactc gggaggctga ggcaggagaa tcgcttgaac ccgggaggtg gaggttacag 1946 tgagccgaga tcataccact gcactccagc ctggcgacag agcaagactc catctcaaaa 2006 ataattaaat aaataaataa ataaataaat aaataaataa ataaaatagt acagacagac 2066 acatgataag ccaaactgtt cctgcaaaca tagctatgct tcatgaggct tacaagaagt 2126 aactttaggt aggagctgtt tttgtttgaa gtactgcaga attatattgt aacttcccct 2186 caccccagtt gcaattgtgt catagtcatc tgtatatcaa actattttat tcccataact 2246 tcattggctt ggatgcctaa gtgtatgatg cttgaagcct cagaaaagaa ataagcatat 2306 ttcaaaagct gcaaaaggtt tttcactgcc tgcctcttgc ggaactgggt tacaccctgg 2366 cactgttctg atccaagcat atttgcttgg ggaactaagt gctgactagt ttgttttcta 2426 tgtcaagggg caatattaaa aaacaatttg caagaaaatg tgtttcaaga gagcaaccta 2486 agctaagtca ctctgcgata tttcttgaaa ataacgacct tgtcttgtat cagtggaaga 2546 agtaagttgc ttagaaaggg aaaagtcaaa ttgttccaga actgctaaaa atcattttaa 2606 aaaccatgat ttagtttgga attatgattg tagtctgttg aatagtattt accatggcat 2666 ttcataccca tggtatttta taccttctga ctatcaattt tagtattatt agatgtttgt 2726 gtaaccactt gcttatttaa atgaattttg agtactgcct aattgtcagt tatatgaata 2786 aattacatgt cattctactg taacgt 2812 <210> 39 <211> 5486 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(1081) <400> 39 a gct gtg tgt gtc att gac atg tcc tct ttc aca aag ttt gag ata aca 49 Ala Val Cys Val Ile Asp Met Ser Ser Phe Thr Lys Phe Glu Ile Thr 1 5 10 15 tcc act ggg gat cag gca tta gaa gtt cta cag tac ctc ttc tcc aat 97 Ser Thr Gly Asp Gln Ala Leu Glu Val Leu Gln Tyr Leu Phe Ser Asn 20 25 30 gac ctg gat gtg cct gtg ggc cac att gtg cat act ggc atg ctc aac 145 Asp Leu Asp Val Pro Val Gly His Ile Val His Thr Gly Met Leu Asn 35 40 45 gag ggt gga ggg tat gaa aat gac tgc agc ata gca cga ctg aac aag 193 Glu Gly Gly Gly Tyr Glu Asn Asp Cys Ser Ile Ala Arg Leu Asn Lys 50 55 60 cgc agt ttc ttc atg atc tct cca acc gac cag cag gtc cac tgt tgg 241 Arg Ser Phe Phe Met Ile Ser Pro Thr Asp Gln Gln Val His Cys Trp 65 70 75 80 gcc tgg ctt aag aaa cac atg ccg aaa gac agc aac ctg ctc ctg gag 289 Ala Trp Leu Lys Lys His Met Pro Lys Asp Ser Asn Leu Leu Leu Glu 85 90 95 gac gtc acc tgg aag tac aca gcc ctc aat ctg att ggc cct cga gct 337 Asp Val Thr Trp Lys Tyr Thr Ala Leu Asn Leu Ile Gly Pro Arg Ala 100 105 110 gtg gat gtg ctg tct gag ttg tcc tat gcc cct atg act cca gac cac 385 Val Asp Val Leu Ser Glu Leu Ser Tyr Ala Pro Met Thr Pro Asp His 115 120 125 ttc cca agc ctc ttt tgc aag gag atg agt gtg ggc tat gca aat ggg 433 Phe Pro Ser Leu Phe Cys Lys Glu Met Ser Val Gly Tyr Ala Asn Gly 130 135 140 atc cgg gtg atg agc atg acg cac aca gga gag cca gga ttc atg ctc 481 Ile Arg Val Met Ser Met Thr His Thr Gly Glu Pro Gly Phe Met Leu 145 150 155 160 tac atc ccc ata gag tac gcc ctg cat gta tac aat gaa gtg atg agt 529 Tyr Ile Pro Ile Glu Tyr Ala Leu His Val Tyr Asn Glu Val Met Ser 165 170 175 gtt ggc cag aaa tac gga atc cgg aat gct ggg tat tac gct ctt cgc 577 Val Gly Gln Lys Tyr Gly Ile Arg Asn Ala Gly Tyr Tyr Ala Leu Arg 180 185 190 agt ctc cga att gag aag ttt ttt gcc ttc tgg ggt cag gat ata aat 625 Ser Leu Arg Ile Glu Lys Phe Phe Ala Phe Trp Gly Gln Asp Ile Asn 195 200 205 aac ctc acc acg ccc ctg gaa tgt gga cga gag tct cgg gtg aaa tta 673 Asn Leu Thr Thr Pro Leu Glu Cys Gly Arg Glu Ser Arg Val Lys Leu 210 215 220 gag aag ggc atg gat ttc att ggt cgc gac gcc ctc ctg cag cag aag 721 Glu Lys Gly Met Asp Phe Ile Gly Arg Asp Ala Leu Leu Gln Gln Lys 225 230 235 240 cag aat gga gtg tat aaa cgc ctc acc atg ttc atc ctg gac gac cat 769 Gln Asn Gly Val Tyr Lys Arg Leu Thr Met Phe Ile Leu Asp Asp His 245 250 255 gat tca gac cta gac ctt tgg cct tgg tgg gga gag ccc att tac cgg 817 Asp Ser Asp Leu Asp Leu Trp Pro Trp Trp Gly Glu Pro Ile Tyr Arg 260 265 270 aat ggg cag tat gtt ggc aag acc acc agc agt gcc tac agc tac agc 865 Asn Gly Gln Tyr Val Gly Lys Thr Thr Ser Ser Ala Tyr Ser Tyr Ser 275 280 285 ctg gag cgc cac gtt tgc ctg ggc ttt gtg cac aat ttt tct gag gac 913 Leu Glu Arg His Val Cys Leu Gly Phe Val His Asn Phe Ser Glu Asp 290 295 300 acg ggg gaa gag caa gtg gtg aca gca gat ttc atc aac cgg gga gag 961 Thr Gly Glu Glu Gln Val Val Thr Ala Asp Phe Ile Asn Arg Gly Glu 305 310 315 320 tat gag att gac atc gcg gga tac cgc ttc cag gcc aag gcc aag ctc 1009 Tyr Glu Ile Asp Ile Ala Gly Tyr Arg Phe Gln Ala Lys Ala Lys Leu 325 330 335 tac cct gtc gcc tcc ctc ttc acc cag aag cgc cga aag gat gac atg 1057 Tyr Pro Val Ala Ser Leu Phe Thr Gln Lys Arg Arg Lys Asp Asp Met 340 345 350 gag ctg agt gac tta cat ggg aag tgatgccacc agggcagcct cacctcctcc 1111 Glu Leu Ser Asp Leu His Gly Lys 355 360 ccatcatctt gtcctagagt gggcgtcacc ttggagcttc tcttccttcc gcctctgttc 1171 ctcttctgga gcctttgcct cccatctctt atctccttga tataattttg aacttgacct 1231 actttaaact tttttgctct gcagccttcc ttgcccttcc acctcctcct cctaatattc 1291 actctgggct cttcttccct tcccacccct cactcagctt ctcgtggtgg caggaggtat 1351 gtctgacagg acagaagcaa gctccactgt ggacatgagt gatggtgaca gctgctttca 1411 aattctgcat ctcaaggcag ggcaagccgg ggtggtgcag gtctcagggc acgagtccct 1471 ctcccttggg ttccattttc ttggagcagc ctattagttc tggtggggtt gccgtgtgtc 1531 ggatgcagcc ctgaggggca gctcgtgcct gcagcccggc agctcgttct cctgttctgc 1591 tgtgctgtgg gctggcactc gatacctctg gcaagaggat gattatctac ctcactgata 1651 agaggcatcg catggacgtt ctctggtctg tagtggagac aagcagttaa cctagcacca 1711 tcctcatcct ccctgcagaa gccattagca gacctttggg ccagggcagc ctccctataa 1771 ttttcttcat ctcttgctaa tctctataat aaggttgctt tttctttctt agttgagtaa 1831 acaagtaagc cacagtgttt gaaagggaaa aaccatattg ccttgtgtgt tgcttttccc 1891 agtcaaaagg gtctgacctt agaaagtccc caccagtgat gctgagtgtt ctgctatgga 1951 aacaatgctg cttttctctc agctgtccaa agttcagccg ttcctccttc cccttctccc 2011 agtgcgtttg actttgtcag gtcagcctca cttgtccctt tcacagttgg cccataaagt 2071 catgtttctc tccctttaga atagggaggg gaagggatca ggtgtgttgt cctgggcctt 2131 tcaaccttgc gggctgtgct gagttccaga gagctgccgg aattccaggt ttgactctcc 2191 agcacagagc agagctacac agaggtgacc cacgttagtc cactgagagt tctgagtcca 2251 aagggtgtac gttgcataag gctagagacc gcttttcctc ctttcccccc aggctctttg 2311 tttccctcca cccacccttc catatcctct ggagcaggag acaatgtggg tgcccagaag 2371 tgccctgcgc tttcaggcag tgtctctgtt ttcccaaggt gaaacttaga tatcatggac 2431 tgttgtccag cctcaatgct tcattttccc cttgcatatc aactgcccta atctgacttt 2491 ttttaagtgc aaataaactg ctataagaca ttttggttag taaaactcta gcctttggcg 2551 tgttggtatc ttggaagcat tagctctgat aggtctataa gtgtattaag ggacatcctt 2611 ccatttcatt agagcagctt aaaatgctca ggtgtctgcc ttctctggtg tttctttggg 2671 atctctgttt acccacttac gctggctcct tctagacatt tcttgccact tccccaacta 2731 gaccactcct agtgattact gactttagtg cctaaacctt tttggaaggt tctggttggc 2791 ttgttagagg agcatatgat tagaattctg tttgggggtc tagttgtctt ggagcaagta 2851 tgtacttaac tagccgagag atgctgcctc taggcagaga ggaggagagg tgttgccggc 2911 tggagggcca accagtgaac accagctgtg aaggccttgg gagaggagga acaggccctt 2971 gggcagatgc aggcattacc agcagggagc agacttacct ccgaagatgg agacaggtga 3031 ctgagagctg caggcctcct ctgctcttcc aaacacgtag catttgcacc cctccaaagc 3091 catctttgta aaggaaaacg tatttgtaat tgaatccaga agaatttagt tacacataga 3151 cataactctt caaccttaac tatggcaata catttgtgct ttaactgtta catagcagta 3211 tcaccactta ccaggatcca aatcgaaata ataaaagctg tctccatagt ttaaaatcga 3271 atagtgccat catcacagta tattagtcaa atagaagctt catcagaaat gtatcccaca 3331 tagagtttta agacttggat tctcttctgc ccttgttaat ctccaactaa ttactacaga 3391 ttgacacgtt tttaattagc tgtcctttgt aagaagtcag gaaatctgat gctgtgtcca 3451 aaattatgca ctgtttgttg aagtagaacc agaaatcctg acctcctgtt aaatgacatc 3511 agtttccccc tctgagcaac agactgcttg tcttgctagg agaggaggat ggggggctga 3571 gcactcaggc tgtccattga aaccccttgt ccatgaatag ggtcatactc ctaagactga 3631 tggggtgttg atcttctagg acatcacttg tttattcagt gccccaaaca cagatttctc 3691 ttctagcact ttagagttga tccttgaagt ctctcctggt tcattcaaat acaagctgtg 3751 tgagtctggt ggttttctgt gattggtcta atgtgagctc tttgaacaga cagatctgac 3811 agtgaatgac tctcccctgc ttctggcata actgctttgc ctctgtctag tgtccaagca 3871 tcttagctgt tcaagaggag agggcagcat aacttcctga ccaccggtgt cagatatcag 3931 agcattctgg actcctgaga ggcagtggcc tcttgagtga acaggggagg ccagtagatg 3991 ccccagatcc agagccgtgg ctgcaaatcc agcaggaata aggagggaca accacagcct 4051 cctcatccat gtgtcatttc caagggtttg ccttgtgtct cagctcattc tgggcagcac 4111 gtttgtcttc tgtccctaga gatttgaagg attttggact cttgtgaatg ggtgactgga 4171 cttggcttta cagagttggg tgcttttttc tctctgcaat tacctgtcat agcattttgt 4231 gctcaccacg aaggatggtc tctgccttct cttgtcggtg tatgccatct gaacctagga 4291 acacaaagta tattggcctc aaacggagac ccagggttgc cagttttccg tgggccttcc 4351 cctcccttga aatgtcttta attacctccc cttcatcgtc aggccacgtg tgacttctgt 4411 tcttagcact gccagggtca ttgacttcca tctaagcttg catcaggaag atgttccttc 4471 tgtgatcatt ggtactgaag ccagaaaagc tctcattcag gaactctgaa gagcaaaaag 4531 ggacaaacac taactgctga gctgggccat ttgatctcct ttcaccttgc attgctgtca 4591 cagcaccttg tatgatggca ggacaggctc cagcagagag aactgcacag tgaccactgt 4651 atttttcacg ctcttccagg gatccctgtc ccccgacatt gaagagatct cattcaggcc 4711 agagacacag agaccacata gcccagtgat taaaccccgg tttcactctg gccccaggag 4771 tggagcctgg ccactcctgt ttggttctca ctgggaggcc cactggcctt ggatcatctc 4831 ctcatgcaca cccggagttt tacctgcttg cttgctttcc tggactgctg tttgcaagaa 4891 agtaactaaa acatgaaaag taaacctcca gcttccacag tatattacct gccgttgcat 4951 gcatttgaaa gttagcctcc tcccttgcca ccgtcttggt ggcagtagcg atgcaagaat 5011 gatgggagct ttccgagagc gttcagtgtt tcactgaaga caggacccat agccttcatt 5071 tctggctctg tgtctcctct ggcatatgga cacatttcct ggcatttgcc tgagtctaca 5131 ccactttttg agaacctgaa atagaaggga atcttctgtg gcccacagtc tccatattgg 5191 cactagaaga ctggcctggc ggaggaattt gcgttggctt gctttcaggg gttagctaca 5251 agattcagct ttatatctct gttgcttctt ggccagtgta gtcaataagg gtcttcttta 5311 acatctaaga tagaggtttg gttggccggg cgtggtcgct tactcctgta atcccagcac 5371 tttgggaggc ccagtgaggt gggagaattg cttgaaccca ggaggcagag gttgcagtga 5431 gctgagattg caccactgca ctccagcctg ggtaacagag tgagactctt gtctc 5486 <210> 40 <211> 4863 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1671) <400> 40 aca gga ctc tcc att tct aag ccc aac atg atc tcc tta ctg gag caa 48 Thr Gly Leu Ser Ile Ser Lys Pro Asn Met Ile Ser Leu Leu Glu Gln 1 5 10 15 ggg aag gaa ccg tgg atg gtg gag aga aag atg tca cag ggt cac tgt 96 Gly Lys Glu Pro Trp Met Val Glu Arg Lys Met Ser Gln Gly His Cys 20 25 30 gca gac tgg gag tct tgg tgt gaa att gag gaa tta tct cca aaa tgg 144 Ala Asp Trp Glu Ser Trp Cys Glu Ile Glu Glu Leu Ser Pro Lys Trp 35 40 45 ttc att gat gaa gat gaa ata tcc cag gag atg gta atg gaa agg cta 192 Phe Ile Asp Glu Asp Glu Ile Ser Gln Glu Met Val Met Glu Arg Leu 50 55 60 gca agt cat ggc ctt gaa tgc tcc agt ttc aga gaa gcc tgg aaa tat 240 Ala Ser His Gly Leu Glu Cys Ser Ser Phe Arg Glu Ala Trp Lys Tyr 65 70 75 80 aag ggt gaa ttt gag cta cat cag gga aat gcg gag agg cat ttc atg 288 Lys Gly Glu Phe Glu Leu His Gln Gly Asn Ala Glu Arg His Phe Met 85 90 95 caa gtg aca gct gtt aag gaa atc tct act ggg aaa aga gac aat gaa 336 Gln Val Thr Ala Val Lys Glu Ile Ser Thr Gly Lys Arg Asp Asn Glu 100 105 110 ttt agt aat tct ggg aga agc ata ccc ctg aaa tca gta ttt tta aca 384 Phe Ser Asn Ser Gly Arg Ser Ile Pro Leu Lys Ser Val Phe Leu Thr 115 120 125 caa cag aaa gtt cct acc ata cag caa gta cat aaa ttt gat att tat 432 Gln Gln Lys Val Pro Thr Ile Gln Gln Val His Lys Phe Asp Ile Tyr 130 135 140 gat aaa ctc ttc ccc caa aat tca gtc ata att gaa tat aaa aga ctc 480 Asp Lys Leu Phe Pro Gln Asn Ser Val Ile Ile Glu Tyr Lys Arg Leu 145 150 155 160 cat gct gag aag gaa tct ttg ata ggt aat gaa tgt gaa gaa ttc aac 528 His Ala Glu Lys Glu Ser Leu Ile Gly Asn Glu Cys Glu Glu Phe Asn 165 170 175 cag agt acg tac ctt agt aaa gat ata gga att cct cct ggg gag aaa 576 Gln Ser Thr Tyr Leu Ser Lys Asp Ile Gly Ile Pro Pro Gly Glu Lys 180 185 190 cct tat gaa agt cat gat ttt tca aag ctc tta agt ttc cac tca tta 624 Pro Tyr Glu Ser His Asp Phe Ser Lys Leu Leu Ser Phe His Ser Leu 195 200 205 ttt act caa cat cag acc act cat ttt gga aaa tta ccc cat gga tac 672 Phe Thr Gln His Gln Thr Thr His Phe Gly Lys Leu Pro His Gly Tyr 210 215 220 gat gaa tgt ggt gat gcc ttt agc tgt tac tca ttc ttt act caa cct 720 Asp Glu Cys Gly Asp Ala Phe Ser Cys Tyr Ser Phe Phe Thr Gln Pro 225 230 235 240 cag aga att cac agt gga gaa aaa cca tat gca tgc aat gac tgt gga 768 Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Ala Cys Asn Asp Cys Gly 245 250 255 aaa gcc ttt agc cac gac ttc ttt ctc agt gaa cat caa aga act cat 816 Lys Ala Phe Ser His Asp Phe Phe Leu Ser Glu His Gln Arg Thr His 260 265 270 att ggg gag aaa cct tat gaa tgt aag gaa tgt aac aaa gct ttc aga 864 Ile Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Asn Lys Ala Phe Arg 275 280 285 cag agt gct cac ctt gct caa cat cag agg atc cac act gga gag aaa 912 Gln Ser Ala His Leu Ala Gln His Gln Arg Ile His Thr Gly Glu Lys 290 295 300 ccg ttt gcg tgc aat gaa tgt ggg aag gcc ttt agc cgt tat gcc ttc 960 Pro Phe Ala Cys Asn Glu Cys Gly Lys Ala Phe Ser Arg Tyr Ala Phe 305 310 315 320 ctt gtt gaa cat cag aga att cac aca ggt gag aaa cca tat gaa tgt 1008 Leu Val Glu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 325 330 335 aaa gaa tgt aat aaa gcc ttc aga cag agt gct cac ctt aat caa cat 1056 Lys Glu Cys Asn Lys Ala Phe Arg Gln Ser Ala His Leu Asn Gln His 340 345 350 cag agg att cac act gga gag aaa ccc tat gaa tgt aat cag tgt gga 1104 Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Gln Cys Gly 355 360 365 aaa gcc ttc agc aga cgc ata gcc ctt act cta cat caa aga att cac 1152 Lys Ala Phe Ser Arg Arg Ile Ala Leu Thr Leu His Gln Arg Ile His 370 375 380 aca gga gag aaa ccc ttc aaa tgt agt gaa tgt ggg aag acc ttt ggc 1200 Thr Gly Glu Lys Pro Phe Lys Cys Ser Glu Cys Gly Lys Thr Phe Gly 385 390 395 400 tat cgc tca cac ctg aat caa cat cag aga att cat acc gga gaa aag 1248 Tyr Arg Ser His Leu Asn Gln His Gln Arg Ile His Thr Gly Glu Lys 405 410 415 ccc tat gaa tgc atc aaa tgt ggg aag ttt ttt agg act gac tca caa 1296 Pro Tyr Glu Cys Ile Lys Cys Gly Lys Phe Phe Arg Thr Asp Ser Gln 420 425 430 ctt aat cga cat cat aga att cac act gga gag aga cca ttt gaa tgc 1344 Leu Asn Arg His His Arg Ile His Thr Gly Glu Arg Pro Phe Glu Cys 435 440 445 agt aaa tgt ggg aaa gcc ttc agt gat gct tta gtt cta att cac cat 1392 Ser Lys Cys Gly Lys Ala Phe Ser Asp Ala Leu Val Leu Ile His His 450 455 460 aag aga agt cat gca gga gag aaa ccc tat gaa tgt aac aaa tgt gga 1440 Lys Arg Ser His Ala Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Gly 465 470 475 480 aag gcc ttc agt tgt ggc tca tat ctt aat caa cat caa aga att cat 1488 Lys Ala Phe Ser Cys Gly Ser Tyr Leu Asn Gln His Gln Arg Ile His 485 490 495 act gga gag aaa ccc tat gaa tgt agt gaa tgt ggg aag gct ttt cat 1536 Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe His 500 505 510 cag atc ttg tcc cta aga cta cac cag aga att cac gct gga gaa aaa 1584 Gln Ile Leu Ser Leu Arg Leu His Gln Arg Ile His Ala Gly Glu Lys 515 520 525 cct tat aaa tgt aac gaa tgt ggg aat aat ttt agc tgt gtc tca gcc 1632 Pro Tyr Lys Cys Asn Glu Cys Gly Asn Asn Phe Ser Cys Val Ser Ala 530 535 540 ctt aga cga cat cag aga att cat aat aga gaa acg ctc tgattataac 1681 Leu Arg Arg His Gln Arg Ile His Asn Arg Glu Thr Leu 545 550 555 aagtatagga aagaaaacat gtggttacca ctcaatcctt attaaatatt agtgagttct 1741 ttttggttag taattctttg aatgtagttc atatttcagt tcatgagtat ccgttatttg 1801 aagtagctca gtagtagaca tctgttactt tttttttttt cagacagagt ctcgctctgt 1861 tgcccaggct ggagtgcagt ggtgtagtct tggctcactg cagcctctgc ctcctgggtt 1921 caagcaatcc tcctgcctca gcctcctgag tagctgggat tacaggtgcc tgccaccata 1981 cctggctaat ttttgtattt ttagtagaga cggggtttca ccacattggt caggctgatc 2041 tcgaactcct gactttaggt gatccacacg cctcagactc ccaaagtgct gggattatgg 2101 gcgtgagcca ccgcgcctgg ccacatctgt tactttttga tctgttctat acctggctta 2161 gcccaccctc aatgcatatg attcagatga aactgttaat cagggacagc agtggactgg 2221 tcacaggctg gccaattatt tcccccaacc tagtgataag ggattggcaa atggccctgt 2281 ctggatcaat gaagtccttt gcgggtattc ctatgggcag taagagaggt tttattctgg 2341 aactgcaagt ttcaaggatt taataagatt aaaaactcac cagtagcctt tttgccactc 2401 atgaggaaag ctttcccaaa gagaaatcta acagaggaaa atggagatga gagacagaaa 2461 tatgatgata cagcttgatc tcctggatcc agtcattcct gacagctaca ccatcaccat 2521 cctttttcat tttttgtgat ccaataaatt tccttttttt gcttaatttg gattatattt 2581 ttgcctcatg gaattagagt gctgattcac acattctatg tttgctatac ataaaagaaa 2641 gccttaattt tttacgtggc ataattattt atcctgagga gcaaccttct gatataacaa 2701 gtttatgaag gttgaataca cagccttcat aaaactgaga taattgttac attttatttg 2761 tcgataaaac tattttagtg tttcttagtt tttttcacat tatggctgaa tattttaaaa 2821 ttcaccaagt aaaattcttt aacaggcttc cccttaagga gttaaaatca tttgtcacag 2881 tgactcacca tttgcctgta aagagagaat ggaaagctaa gagaataata ctttcatttg 2941 tttaatgaat ggctcttcat cttcaaggaa ttacttgatt ttcttctttc agtatgggtc 3001 taaacatatt ctgtggcaga atataataac aattaaattg taaatgaggt cttttgtggg 3061 tgggctctaa atttggttta agacccagtg cggtggctca cgcctgtagt ccgagcactt 3121 tgggaggccg aggtgggcag atcacctgag gtcaggagtt cgagaccagc ctgaccagca 3181 tggagaaacc ccgtctctac taaaaataca gaattagccg ggtgtggtgg tgcgtgcttg 3241 tagtcccagc tactcaggag ggtggggcgg gagggtcgct tgagcctggg aagtggaggt 3301 tgcagtgagc ggagatcgcg ccattgtact ccagcctggg caacaagagc gaaactcctt 3361 ctcaaaaaaa aaaaaaaaat aaataaataa ataaataaat aaataaataa atttggttta 3421 agaagtgtat ggataacttc tttgcagcta gagatatcaa acaaagatat tgctggcaga 3481 aagaatgagt catttttaac aaatggtaaa agtaaagcag ttaatgccta aaatttttag 3541 agactaaatc atttccatta ttgggagtaa tgaggaagat gaaggtgtag ggcaatacgt 3601 ttctttttta tctgagtgga tatagggaaa taaactggtg atatggcagc tgggccatct 3661 tgaatagtga gaaccagtaa gaatattggg tattgcctga agagcatctg taaaaacata 3721 tcagaacaaa tgaaagagga aagaatgaag gatttatatg tgtgcataga gtgaatatat 3781 gtgtgcatag agtgaaatat tcaacttata cttatttcta ataaaatctg aaaattattt 3841 ttcataaata ttcaaattcc ctttaaacag cttaaaatac agatttagtg actcagtact 3901 tcaaaccttg aatagaaaca aatatgatta taaaatattt ccaaacttat gttacatcta 3961 atctgaaaca tattaatatt ataagcttaa ttcatgtcat catttcttta ttttttatta 4021 tatttcctgg aggtataagg atatttattt ttataatttc caagcactga gtaataattt 4081 atttcagaaa gtttcagaag gttacagtaa actttaccaa acttgaagaa gaatgactca 4141 gatcagtaag aagagtctga gttactcact aattgatttt tattttattt atttattttt 4201 tttgagacgg ggtctcgctc tgttatccag gctggagtgc ggtgacacaa tcatggctcg 4261 ctgcggcctc aacttcccag gctcgggcgg ccctcccgcc tcggcctcct gagtggctgg 4321 gactgcgggt gtgctctacc acgcctggct gagtttcgcg tttttctgta gagatggggt 4381 ttcgcgagtt gcccaggctg gtctccaact cttggcctgg agtgatttgc ccatctcggc 4441 ttcccaaagt gctgggatta tagggatgag tcactgtgca cagctactaa ttgatttttg 4501 atctatgtat ggcacctgat ttcatcctcg agagtgacgt aaacctaagc tactggttca 4561 ttctctgttt atatagttaa acttcacttg taatgttgat aaaatctttt gtacccatgt 4621 gtttagcttc agtgtatttt acaatctgat gtttctcctc acaatgaagt actaaatttt 4681 gtttcttttc aactgtacaa cccattgtct tgtgatatat tgacctgatc tcttaggatt 4741 agtgaaaatt tatgctttat taatatttga ttgttattag gaccatctag agatttctgt 4801 ttatgtgtgt gtatgtgcat ctgaagatgt gtattttatt taaatttttt gtattaagtg 4861 cc 4863 <210> 41 <211> 4702 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(1459) <400> 41 g tcg gct ccg ttt ccc ttt ccg ggc ggg cag gcg gcg gac ccc agt gtc 49 Ser Ala Pro Phe Pro Phe Pro Gly Gly Gln Ala Ala Asp Pro Ser Val 1 5 10 15 ttt atc cct ctt ttg cac agt cag ctt ctg cag ctc tcc cgg gct agc 97 Phe Ile Pro Leu Leu His Ser Gln Leu Leu Gln Leu Ser Arg Ala Ser 20 25 30 atg gca gcg tgg aag agt tgg acg gcc ctg cgg ctc tgc gcc aca gtt 145 Met Ala Ala Trp Lys Ser Trp Thr Ala Leu Arg Leu Cys Ala Thr Val 35 40 45 gtt gta ctt gat atg gtc gtc tgt aaa gga ttt gta gaa gat tta gat 193 Val Val Leu Asp Met Val Val Cys Lys Gly Phe Val Glu Asp Leu Asp 50 55 60 gaa tcg ttt aaa gaa aat cga aat gat gac att tgg ctt gta gat ttt 241 Glu Ser Phe Lys Glu Asn Arg Asn Asp Asp Ile Trp Leu Val Asp Phe 65 70 75 80 tat gcg cca tgg tgt ggc cat tgt aaa aag ctg gaa cca att tgg aat 289 Tyr Ala Pro Trp Cys Gly His Cys Lys Lys Leu Glu Pro Ile Trp Asn 85 90 95 gaa gtt ggt ctt gag atg aaa agc att ggt tct cca gtt aag gtt gga 337 Glu Val Gly Leu Glu Met Lys Ser Ile Gly Ser Pro Val Lys Val Gly 100 105 110 aag atg gat gct act tcc tat tct agc att gct tca gag ttt gga gtt 385 Lys Met Asp Ala Thr Ser Tyr Ser Ser Ile Ala Ser Glu Phe Gly Val 115 120 125 cga ggt tat cca aca att aag cta tta aaa ggg gac ttg gca tat aat 433 Arg Gly Tyr Pro Thr Ile Lys Leu Leu Lys Gly Asp Leu Ala Tyr Asn 130 135 140 tat aga gga cca cga aca aaa gat gat att att gag ttt gct cac aga 481 Tyr Arg Gly Pro Arg Thr Lys Asp Asp Ile Ile Glu Phe Ala His Arg 145 150 155 160 gta tct ggg gct cta att cgg cca ctt cca agt caa caa atg ttt gaa 529 Val Ser Gly Ala Leu Ile Arg Pro Leu Pro Ser Gln Gln Met Phe Glu 165 170 175 cat atg cag aag aga cac cgt gta ttt ttc gtt tat gta ggt gga gaa 577 His Met Gln Lys Arg His Arg Val Phe Phe Val Tyr Val Gly Gly Glu 180 185 190 tca cct ttg aaa gag aaa tac ata gat gct gct tca gaa ttg att gta 625 Ser Pro Leu Lys Glu Lys Tyr Ile Asp Ala Ala Ser Glu Leu Ile Val 195 200 205 tat aca tac ttc ttt tct gcc tca gaa gaa gtg gtt cct gag tat gtg 673 Tyr Thr Tyr Phe Phe Ser Ala Ser Glu Glu Val Val Pro Glu Tyr Val 210 215 220 aca cta aaa gag atg cca gct gtg ctt gtt ttc aaa gat gaa act tac 721 Thr Leu Lys Glu Met Pro Ala Val Leu Val Phe Lys Asp Glu Thr Tyr 225 230 235 240 ttt gtt tat gat gag tat gaa gat ggt gat ctg tca tca tgg atc aac 769 Phe Val Tyr Asp Glu Tyr Glu Asp Gly Asp Leu Ser Ser Trp Ile Asn 245 250 255 agg gaa agg ttt cag aat tac ctt gct atg gat ggc ttc ctc ttg tat 817 Arg Glu Arg Phe Gln Asn Tyr Leu Ala Met Asp Gly Phe Leu Leu Tyr 260 265 270 gaa ctt gga gac aca gga aag ctt gtg gct ctt gca gtt att gat gag 865 Glu Leu Gly Asp Thr Gly Lys Leu Val Ala Leu Ala Val Ile Asp Glu 275 280 285 aaa aat aca tca gtt gaa cat acc aga ttg aag tca att att cag gaa 913 Lys Asn Thr Ser Val Glu His Thr Arg Leu Lys Ser Ile Ile Gln Glu 290 295 300 gtt gca aga gat tac aga gac ctc ttc cat agg gat ttt cag ttt ggc 961 Val Ala Arg Asp Tyr Arg Asp Leu Phe His Arg Asp Phe Gln Phe Gly 305 310 315 320 cac atg gat gga aat gac tac ata aat acc ttg ctg atg gat gaa ttg 1009 His Met Asp Gly Asn Asp Tyr Ile Asn Thr Leu Leu Met Asp Glu Leu 325 330 335 aca gtc cca act gta gtt gta ctg aat act tca aac cag caa tat ttc 1057 Thr Val Pro Thr Val Val Val Leu Asn Thr Ser Asn Gln Gln Tyr Phe 340 345 350 ttg cta gat aga cag att aag aat gtt gaa gac atg gtc cag ttt att 1105 Leu Leu Asp Arg Gln Ile Lys Asn Val Glu Asp Met Val Gln Phe Ile 355 360 365 aat aac att ttg gat ggc aca gta gaa gcc caa gga ggt gat agc att 1153 Asn Asn Ile Leu Asp Gly Thr Val Glu Ala Gln Gly Gly Asp Ser Ile 370 375 380 ttg cag aga ttg aaa aga ata gta ttt gat gcc aaa tct act att gtg 1201 Leu Gln Arg Leu Lys Arg Ile Val Phe Asp Ala Lys Ser Thr Ile Val 385 390 395 400 tct ata ttc aag agc tca cca ctg atg ggc tgc ttt ctc ttt ggc ctg 1249 Ser Ile Phe Lys Ser Ser Pro Leu Met Gly Cys Phe Leu Phe Gly Leu 405 410 415 cca ctg ggt gtc atc agt atc atg tgc tat gga atc tac aca gcc gac 1297 Pro Leu Gly Val Ile Ser Ile Met Cys Tyr Gly Ile Tyr Thr Ala Asp 420 425 430 aca gat gga ggt tat ata gaa gaa cga tat gaa gtg tct aaa agt gaa 1345 Thr Asp Gly Gly Tyr Ile Glu Glu Arg Tyr Glu Val Ser Lys Ser Glu 435 440 445 aat gaa aac caa gaa cag ata gaa gag agc aaa gaa cag cag gag ccc 1393 Asn Glu Asn Gln Glu Gln Ile Glu Glu Ser Lys Glu Gln Gln Glu Pro 450 455 460 agc agt gga gga tct gta gtg cct aca gtg cag gag ccc aag gat gta 1441 Ser Ser Gly Gly Ser Val Val Pro Thr Val Gln Glu Pro Lys Asp Val 465 470 475 480 tta gaa aag aag aaa gat tgagacttga tgactataaa atatttgtta 1489 Leu Glu Lys Lys Lys Asp 485 ggacttcaaa ttattaaaga gtctatttat tgaatttaga catttaatca tgatctttac 1549 agaaaagaac atgttattcg tattttgcta atatcaactg catggattaa agtagtccct 1609 ccatacatgg ggaagtgttt ggagcaaaga gatgaacagt ttgtctgaaa caaacacaga 1669 gcactccatc aaaatttacc tgatctttgt gattagaaca gaacaattct atttgcatgt 1729 ttctctatct gaatattctg tgacaaaaag ttaagattct tgggcagaat atttaaattg 1789 gtcagtcagg tagaagatac atgtgtgata tagaaaaata atgcctctcc tgctgccatc 1849 cgtttccctc atatattttg gacaagattt atatggacaa aattaagtct ttaaaattta 1909 ggcactttaa ggagaactaa taactttttc catgtatcaa gattatgagg ttaaaaataa 1969 tgtggtttta tatagcatag tggttttatt ttgttagtta tttttaaagg agaagaaatg 2029 ttacttttta actttatact cagttgcatt atcataaaat tttcatatat gcctagataa 2089 tggggaaaaa aagtcttgtg attgactttc gcaaaataaa caggatttac tgagtagagg 2149 tttcagccca ttccttggaa tactaacagg tatttcatca gtcattgtag gttgggaagg 2209 gtctctgtta atcctactct gctttagcca gaatagccta gtattttatt tctattttat 2269 atattgagat ttcttctaac atttcctttg ataaaaatct tctgcttttt gaaaagtggt 2329 atgtatcata tttttatgtt tctggtgtgt gaactttatg gtaacttcta ctctagaata 2389 cgtacgtatg cacccacaga cacacacagt ttattgacac atctattatg taatgctgta 2449 gacctgtccg tgtctgcttc ataaggagta acgactgaca ttagcatgtc cagtgacaag 2509 tcacatccgg tgtaaaaaaa agagatcagc cagttacctt ctccattgtc ttagttctgt 2569 cacccatttc gtcaagtgac ctctcatctt ctataaacta atacaggaat tctttccaaa 2629 gcaatgtcta aaaactcttt ttttaaaagt aacagtttgg tatgtttatt gtagataaat 2689 tatttttgag gccttcattt tagctaagtt tagaatttat attaggcaac tatgatttga 2749 gtggttattc attgagtaat tttccactat aaagaatttt attgaacatt tattaaaaaa 2809 taatgtaatg catggtcaaa aaatatgtaa ttcatggtct ggacactgac gttgtttagg 2869 gatttagtca tcaaggacag ccctctgttg tttctaatgc catactaatc aagactgtat 2929 ggacacttgc atcttaagta ctaaggaatt actagtgatt gttttatttt atccatgtac 2989 tcttttagta tttaataatt aaatacctat tcttagtgtt tgacactcca tatttctttt 3049 ttttggaaat gaaacaaata tgcagtccaa aattcaggaa ctactagagt gaaatgatat 3109 taagtggaaa ccagagataa atgctgttaa tttaacaagt agattcttct ccaaagaatg 3169 atgagtgatt cttgggaaga taaatgttaa tgttcccaat agtcaagctt gttttgcagt 3229 agtgaaaagc ttagatgagt acggatacct catttgaaac tcagcctagt aaggaagtga 3289 aaacttagca gtcagtgaca tggggaaata gttatagaaa atgtcactga attttttcat 3349 atttataatt agtcatttac atatttttgt cttgttgatc attacctgta aatgaaagac 3409 cttaatagga aaaaaagagt aaagctcagt gtgaatgcaa acatccacaa aatatgatct 3469 tcgtttatat tctgtgatgt tgtttataaa tgaatgcctc agttctctgc tacccttttc 3529 acagctttgt actgtttgcc ttatattcta tttgtgcttt taaagtgtgt ctgttgggaa 3589 aacaaaatgt gtaggtggtt tgtaagtgaa taatttttat ttcttcttgt attaaaattt 3649 tgtttttttc tctactttgg gagatgttta tttacattgt cagactattc acaaaacaga 3709 ttctaaaatt tgtttgctcg tatgctgttc ccttcaatgt gatatcagag attactatga 3769 atgttagttt cattccgtga aacattactt ccatataaag acagatctct taataagtga 3829 atctagtgga agaacatagg tatcattcta attccatggt aaattttgtc atgattctat 3889 atgaataatg gggtccttca ggaagttgga atttttgcct tctcttaatt gcagtgaagt 3949 tctctttata acttctaaaa tttggaattc tagatccttg cttttgcaga atttggtgct 4009 cagacaatat ttaaggacat ttcagcgaga caaagtgcat gtttttatcg agtaccctgt 4069 gcaccacatt atatctggca attctttttg tttcattatg tgcatcaata tttttctcag 4129 ctactattac ctgaaacttg tttaacatgt attagaccta gaattttcat tttctttctc 4189 acatagttgc ttcctggtat ctgatttaga aataacattt aaatgccaag tatctggggg 4249 attgaaggaa gggtctatat gagcaggtga attagcagta ctgtttttgt ttagtggata 4309 ttgttagtga ctttttgtgt gtgttttgct ttgggacctt tttattttgg tgttgcaaaa 4369 agtaacatat tttcatcatt gcttcatacg acatggagtt aggacaggga aaaatcattc 4429 aacactcctt atgcattaaa tgatcaaata aaccagtgta ggatattaag actatcaatt 4489 ggtgggatta ggcttgacat tttattttta taaatatata ttttttctga atgtgtctga 4549 gtccaagagt gggcaaaaaa taattttcta ctttggacta atctatagag gtttttgaaa 4609 gtctgcatta ctaacttgtt gaattcatga tattctgcct atggcacaaa ttgtaaacct 4669 ttgtttttct aaaataaagt aattgaaaac ctg 4702 <210> 42 <211> 4278 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (688)..(2676) <400> 42 tgggggtctc agtgcatctc cttctcctct ctgcctgcct cctccctcac cgaagggtta 60 gcggacaccc atccttttct gcttggggac cccaccacca cccgcaacac tgccgctgtc 120 tcttcttcac cgtatccttc tctacccacc ctcttctctc ttctcttctc cctgcccctt 180 taaatctgcc tggcccagcc tcccccgtga tgctgggatg gagcaaacat tgatttgtgc 240 tgggatggaa tcggaatttt gatttatttt tcctctccca accataagaa gaaaaaaata 300 ataaaaacac cccctcttga gagccccctc cccctttgca tccagctccc agctcttctt 360 ccctatctcc atccaaggca gattttttcc cctacactat tctcatcttc ccccaccctt 420 gccactacct cgccccccca cccagcctgc tcctccagct ggggagagag gggactctcc 480 ggactccccc acctttcctc tctgggttgg agcagtctct ccggaagggg agggggcttg 540 gcttgtccgg gcgaggtggg agtggaggta tcctgccatg gatgctgtgc cggggaggca 600 gcctgagccc cagcccacat gccactcagg atgagggtcc ggccctgcct gccctcgctg 660 gggccccccc gcccggcccc ggtctaa ctg ccc ccg ccc cga ggc ctc gcc cgg 714 Leu Pro Pro Pro Arg Gly Leu Ala Arg 1 5 ctc caa ggc ccc cag cag gct ctc cag tcc cag gat gcg ctg agc cgc 762 Leu Gln Gly Pro Gln Gln Ala Leu Gln Ser Gln Asp Ala Leu Ser Arg 10 15 20 25 cgg ggg gct gag gcc gcg cca act aca tgc atg tcc ccc ggg ggc aag 810 Arg Gly Ala Glu Ala Ala Pro Thr Thr Cys Met Ser Pro Gly Gly Lys 30 35 40 ttc gac ttt gac gac ggg ggc tgc tac gtg ggg ggc tgg gag gcg ggg 858 Phe Asp Phe Asp Asp Gly Gly Cys Tyr Val Gly Gly Trp Glu Ala Gly 45 50 55 cgg gca cat ggc tac ggc gtg tgc acg ggc ccc ggc gcc cag ggc gag 906 Arg Ala His Gly Tyr Gly Val Cys Thr Gly Pro Gly Ala Gln Gly Glu 60 65 70 tac agc ggc tgc tgg gca cac ggc ttc gag tca ctg ggc gtc ttc acg 954 Tyr Ser Gly Cys Trp Ala His Gly Phe Glu Ser Leu Gly Val Phe Thr 75 80 85 ggg ccc ggc gga cac agc tac cag ggc cac tgg cag cag ggc aag cgc 1002 Gly Pro Gly Gly His Ser Tyr Gln Gly His Trp Gln Gln Gly Lys Arg 90 95 100 105 gaa ggg ctg ggc gtg gag cgc aag agc cgc tgg acg tac cgc ggc gag 1050 Glu Gly Leu Gly Val Glu Arg Lys Ser Arg Trp Thr Tyr Arg Gly Glu 110 115 120 tgg ctg ggc ggg ctg aag ggg cgc agc ggc gtg tgg gaa agc gtg tcc 1098 Trp Leu Gly Gly Leu Lys Gly Arg Ser Gly Val Trp Glu Ser Val Ser 125 130 135 ggc ctg cgc tac gcc ggg ctc tgg aag gac ggt ttc cag gac ggc tac 1146 Gly Leu Arg Tyr Ala Gly Leu Trp Lys Asp Gly Phe Gln Asp Gly Tyr 140 145 150 ggc act gag acc tac tcc gac gga ggc acc tac cag ggc cag tgg cag 1194 Gly Thr Glu Thr Tyr Ser Asp Gly Gly Thr Tyr Gln Gly Gln Trp Gln 155 160 165 gcc ggg aag cgc cac ggc tac ggg gta cgc cag agt gtg ccc tac cat 1242 Ala Gly Lys Arg His Gly Tyr Gly Val Arg Gln Ser Val Pro Tyr His 170 175 180 185 cag gcg gcg ctg ctg cgc tcg ccc cgc cgc acc tcc ctg gat tcc ggc 1290 Gln Ala Ala Leu Leu Arg Ser Pro Arg Arg Thr Ser Leu Asp Ser Gly 190 195 200 cac agc gac ccc ccg acg cca ccc ccg ccc ctg ccc ttg ccg ggc gac 1338 His Ser Asp Pro Pro Thr Pro Pro Pro Pro Leu Pro Leu Pro Gly Asp 205 210 215 gag gga ggc agc ccc gcc tcg ggc tcc cgg ggc ggc ttc gtg ctg gcc 1386 Glu Gly Gly Ser Pro Ala Ser Gly Ser Arg Gly Gly Phe Val Leu Ala 220 225 230 ggg ccc ggg gac gcc gac ggc gcg tcg tcc cga aag cgc act ccg gcg 1434 Gly Pro Gly Asp Ala Asp Gly Ala Ser Ser Arg Lys Arg Thr Pro Ala 235 240 245 gcc ggc gga ttc ttt cgc cgt tcg ctg ctg ctc agc ggg ctc cga gcg 1482 Ala Gly Gly Phe Phe Arg Arg Ser Leu Leu Leu Ser Gly Leu Arg Ala 250 255 260 265 ggc gga cgt cgc agc tcc ctg ggc agc aag cga ggc tcc ctg cgc agc 1530 Gly Gly Arg Arg Ser Ser Leu Gly Ser Lys Arg Gly Ser Leu Arg Ser 270 275 280 gag gtg agc agc gag gtg ggc agc acc gga ccg ccc ggc tcg gag gcc 1578 Glu Val Ser Ser Glu Val Gly Ser Thr Gly Pro Pro Gly Ser Glu Ala 285 290 295 agc ggg ccc ccg gcc gca gcg ccg ccc gcc ctc atc gag ggc tcg gcc 1626 Ser Gly Pro Pro Ala Ala Ala Pro Pro Ala Leu Ile Glu Gly Ser Ala 300 305 310 aca gag gtg tac gcg ggc gag tgg cgc gca gat cgg cgc agc ggc ttc 1674 Thr Glu Val Tyr Ala Gly Glu Trp Arg Ala Asp Arg Arg Ser Gly Phe 315 320 325 ggc gtc agc cag cgc tcc aac ggg ctg cgc tac gag ggc gag tgg ctg 1722 Gly Val Ser Gln Arg Ser Asn Gly Leu Arg Tyr Glu Gly Glu Trp Leu 330 335 340 345 ggc aac cgg cgg cac ggc tac ggg cgc acc acc cgc ccc gac ggc tcc 1770 Gly Asn Arg Arg His Gly Tyr Gly Arg Thr Thr Arg Pro Asp Gly Ser 350 355 360 cgc gag gag ggc aag tac aag cgc aac cgg ctg gtg cac ggc ggg cgc 1818 Arg Glu Glu Gly Lys Tyr Lys Arg Asn Arg Leu Val His Gly Gly Arg 365 370 375 gtc cgc agt ctc ctg cct ctg gcc ctt cgg cgg ggc aag gtt aag gag 1866 Val Arg Ser Leu Leu Pro Leu Ala Leu Arg Arg Gly Lys Val Lys Glu 380 385 390 aag gtg gac agg gct gtc gag ggc gcc cgt cga gcc gtg agt gct gcc 1914 Lys Val Asp Arg Ala Val Glu Gly Ala Arg Arg Ala Val Ser Ala Ala 395 400 405 cgt cag cgc cag gag atc gcc gct gcc agg gca gca gac gcc ctc cta 1962 Arg Gln Arg Gln Glu Ile Ala Ala Ala Arg Ala Ala Asp Ala Leu Leu 410 415 420 425 aag gca gtg gca gcc agc agt gtc gct gag aag gcc gtg gag gca gct 2010 Lys Ala Val Ala Ala Ser Ser Val Ala Glu Lys Ala Val Glu Ala Ala 430 435 440 cga atg gcc aaa ctg ata gcc cag gac ctg cag ccc atg cta gag gcc 2058 Arg Met Ala Lys Leu Ile Ala Gln Asp Leu Gln Pro Met Leu Glu Ala 445 450 455 cca ggc cgc aga ccc agg cag gac tca gaa ggt tcc gac acg gag ccc 2106 Pro Gly Arg Arg Pro Arg Gln Asp Ser Glu Gly Ser Asp Thr Glu Pro 460 465 470 ctg gat gag gac agc cct ggg gta tat gag aac gga ctg acc ccc tca 2154 Leu Asp Glu Asp Ser Pro Gly Val Tyr Glu Asn Gly Leu Thr Pro Ser 475 480 485 gag gga tcc cct gaa ctg ccc agc agt cct gcc tcc tcc cgc caa ccc 2202 Glu Gly Ser Pro Glu Leu Pro Ser Ser Pro Ala Ser Ser Arg Gln Pro 490 495 500 505 tgg cga ccc cct gcc tgc cgg agc cca ctg cct cct gga ggg gac cag 2250 Trp Arg Pro Pro Ala Cys Arg Ser Pro Leu Pro Pro Gly Gly Asp Gln 510 515 520 ggt ccc ttc tcc agc ccc aaa gct tgg cct gag gag tgg ggg ggg gca 2298 Gly Pro Phe Ser Ser Pro Lys Ala Trp Pro Glu Glu Trp Gly Gly Ala 525 530 535 ggc gca cag gca gag gaa cta gct ggc tat gag gct gag gat gag gct 2346 Gly Ala Gln Ala Glu Glu Leu Ala Gly Tyr Glu Ala Glu Asp Glu Ala 540 545 550 ggg atg caa ggg cca ggg ccc aga gac ggt tcc cca ctc ctc gga ggc 2394 Gly Met Gln Gly Pro Gly Pro Arg Asp Gly Ser Pro Leu Leu Gly Gly 555 560 565 tgc agc gac agt tca gga agt ctt cga gag gag gag ggg gag gat gaa 2442 Cys Ser Asp Ser Ser Gly Ser Leu Arg Glu Glu Glu Gly Glu Asp Glu 570 575 580 585 gag ccc ctg ccc ccg ctg agg gcc cca gca ggc acg gag cct gag ccc 2490 Glu Pro Leu Pro Pro Leu Arg Ala Pro Ala Gly Thr Glu Pro Glu Pro 590 595 600 atc gcc atg ctg gtc ctg agg ggc tcg tcc tcg agg ggt cct gat gct 2538 Ile Ala Met Leu Val Leu Arg Gly Ser Ser Ser Arg Gly Pro Asp Ala 605 610 615 ggg tgc ctg aca gaa gag ctc ggg gag ccc gct gca acc gag agg cct 2586 Gly Cys Leu Thr Glu Glu Leu Gly Glu Pro Ala Ala Thr Glu Arg Pro 620 625 630 gcc cag ccg gga gct gcc aac ccc ctg gtg gtg gga gcc gtg gcc ctc 2634 Ala Gln Pro Gly Ala Ala Asn Pro Leu Val Val Gly Ala Val Ala Leu 635 640 645 ctg gac ctc agc ctg gca ttc ctg ttc tcc cag ctc ctc acc 2676 Leu Asp Leu Ser Leu Ala Phe Leu Phe Ser Gln Leu Leu Thr 650 655 660 tgaggctact tcctggcctg gttctggctt tggttgcgtg cctcttcacc cctttgacct 2736 gccttttttc tcttctcctc ttcctggctg tgttttctcc tatctttctt tctcttcttc 2796 ctttcttttc tgtgctcctt tgtttttttc tctcgctttt tctttccctg tcttctttca 2856 gattatctca tttcttctgg atctgtctct gtattcctca ctcccttccc catcccaacc 2916 ccttctttct ctagattgtt tacatatgaa gggcttttct ctctcagagt tgctgtcttc 2976 tctgagacac acaaatctaa gtcagaccat tgctccacgc cctcccacct tttctttaga 3036 cctcaacttc gctgcgggtg ggggtttggt gtcctaagga gactcctgga agctgaatgg 3096 agaggaggaa gaaaatgaag aaggagtgat tgaatgtcgg gcaaggcact ggctgagctg 3156 ctgtggctcc ctagcctaag gggcctgctg tccctctgag gcctagtgaa aaagctgcag 3216 gaggtgcatc ctccacctct aatcttggag gctattatct tacctccaag cactgagctg 3276 ggttactgcc caattccatc cttccctgaa ggagagaagg gaagtgaaaa gtagagtaac 3336 tccccagcat ttccctcttt ttctcctcat cggccagccc ctcctccagc cccctctggt 3396 ggcatgccat gccaagagca acgtgtaaag gaacagagaa tatccaatgc agtcaagtcc 3456 accctgccca gactttgcca ctgacttctc ccacccttct gtctccccca taatagttta 3516 tttggttggt ctggactcac ttgtggcctt tgattaaatt cctaaggggc ctgaagaaga 3576 catttctact gcagagggtt agaggcactt gagcaaggcc cccacatccc aactctggga 3636 gttgtggtgg gaggaggcac ttctggggga taggaccaga caagataaca ggagctcaca 3696 tggaagcaga agctgtgaca agtttagtag tcccaaaatg ggttatatcc cttccccctt 3756 tacatcagaa tcttgtgaaa tgggaaaaca acagaaggag gggatcaaag atagctgatc 3816 tcacatgctt cccaggcagg gcagaggtgg gagtcaaacc cgggtgacag gtgggtggag 3876 agccctgttt gaggttgtgg ctgatccctc tctggtatta gtttttcccc tgggagcagg 3936 aagccctagg aagaggggac tgcagggtcc ccaggggatc tttcctccct cccctgcatg 3996 aggcagaggc aagctgcctg ccaaccccct ccctcaagga atggccttgc ccaggaatgc 4056 ccaccacaca taccctcttc tttttttcta gtcaaactct tgtttattcc ttggcttgcc 4116 tccctccttc ctcccctctc aacctttact tctgatttct atttcatgga atttgggatt 4176 gaagttaaac tacaacagtg ccgccaacac caagtcttgc aggaaaaaaa tacaaagaaa 4236 tttaacaaaa aaaatatatt aataaaaaag ttcaaaaaag gg 4278 <210> 43 <211> 3848 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(235) <400> 43 g ccg gaa ccg cgc ggg tcg tcg cag ctg cgg gtg aac gcg gcg ttt gcc 49 Pro Glu Pro Arg Gly Ser Ser Gln Leu Arg Val Asn Ala Ala Phe Ala 1 5 10 15 gcg cgg tac aac cgc tac cgg gag cgc gag gaa ctg cag cgg ctg aag 97 Ala Arg Tyr Asn Arg Tyr Arg Glu Arg Glu Glu Leu Gln Arg Leu Lys 20 25 30 gat cgc tac ggg gac cga gac agc agc agc gac tcc agt tcc gag tcg 145 Asp Arg Tyr Gly Asp Arg Asp Ser Ser Ser Asp Ser Ser Ser Glu Ser 35 40 45 gac tca agc gac gag cgc gtg gtg cgc gtc ccc gcc ccg tcc tgg acg 193 Asp Ser Ser Asp Glu Arg Val Val Arg Val Pro Ala Pro Ser Trp Thr 50 55 60 tgc gga ggc gtc caa gcc ccc cac tgc acc ccg acc ccg atg 235 Cys Gly Gly Val Gln Ala Pro His Cys Thr Pro Thr Pro Met 65 70 75 tagacggggg ggaaccccca accccagagc gccctgcggg agcgtcccat cctccgctcc 295 ccatcccatg agggacagac agtgcccccc ctctccccag gggagccaaa tccccgttat 355 tttctctccc ctgccacgat ccccacctgc ccactctgat gtgtggggcg actctgtccc 415 ccaagaaccc cccctttcct ctttcatcct caagagtcta gccatttttt agtgtactcc 475 ttgcgccacg tggggcgccc aacttctcac atcagccctg atcctggccc cactgtgcgg 535 cctggcccag cccctccccg ctgtctctct tgtgccctca gcccacctgc cccttgtcaa 595 gtctttgtct tccccaggaa ttaccttctc cttgcccctc accttcctct acccatatcc 655 tgtacctacc tgtggcctgc ccctgcccac cccaagaggg cccctctccc tcctgctgtt 715 tgaccacctg tttgacctcc ccagccagat ccacccccct ccatcctaat ccctacgctg 775 agctcacctg ctggcgccag ggctcttatt atctcccttc tgaaatctat ccccaaccct 835 tttcctgccc taggaatttg atccccagca ggagcgggac ttttacaaaa cgctctcctt 895 gttgaagaag aaggaccccc gcatttatca gaaagatgcc accttctata acagaacagg 955 tccggggcca ctcctgtcta aacctctcct tcctctggag cagaatccgg ggtcctttcc 1015 tgactgtgga ttcagagaag tgacttgact tctctgagcc tcttttcctg tctgtaaagt 1075 atatctaacg gtagcatctc ccctcagggc tgttttaagg atagattggg atttacccag 1135 tttacacagt tcatctgttt tgactattga atgaattgct tcacaagtca caagtcctta 1195 gcagagccta ggttattacc tggtggtggg gttaatgact gtgtccttgg cactattcaa 1255 ggtgggaatt gctgactgaa tgattccaac tccaccaggc tgggcaggtg gttcaagcat 1315 ctaatcccag cactttggga ggctgaggtg ggagggtcaa ttgaggccag gagtttgaga 1375 ccagtttggc caacatagca agaccccatt tctctttttt ttttttgaaa tggagtttca 1435 ctcttgttgc ccaggctggg ttgcaatggg acgatctcgg ctcactgcag cctccgtctc 1495 ccaggttcaa gcgattctcc tgcctcagcc tcctgagtag ctggaattac aggcacgcgc 1555 caccacgccc agctaatttg ggatttttag tagagacagg gtttctccat gttggccagg 1615 ctggtctcga actcccaact tcaggtgatc cgcccaccct ggcctcccaa agtgctggga 1675 ttacaggcgt gagccactgc gcccagccag cctttctttc ttttttcttt tttttttttg 1735 agacggagtt ttgctcttgt tgcccaagct ggagtgcaat ggcgtgatct gggctcgctg 1795 cagcctccgc ctccccggtt caaccgattc tcctgcctca gcctcctgag tggctgggat 1855 tgcgggtgcg tgccaccacg cccagctact ttttgttatt tttagtagag atggggtttc 1915 accatgttgg ccaggctggt ctcgaactcc tgacctcagg taatccatcc gccttggcct 1975 cccaaagtgc taggattgca ggtgtgagcc actgtgcctg gcggcaagac cccatctcta 2035 caaaagattc agaactcagc tgagcatgct ggtgtgcgct tatagtccca ggtatttggg 2095 aggctgaagt gggaggattg cttaagccca tgagttcaag gctgcagtga gctgtgggct 2155 aggatgttga cactgcactc cagcctgagc aagagtaaga ctccaactct caaaaaaatt 2215 aattataata attaatcagg ctgggcatgg tggctcatgc ctgtaatcct ggcactttgg 2275 gaggttgagg cgggaggatc acttgaggtc aggagttcga gaccagcctg gccaacatgg 2335 tggaacccca tctctactaa aaataacaaa aattagctgg gcgtggtggt gcacacccgt 2395 gatcccagct actcaggagg ctgaggcagg ggaatcgctt gaacctggga ggcggaggtt 2455 gcagtgagcc aagatcacgc catgcactgg gcaacggagt gagactctgt ctcaaaaaaa 2515 taataataat ggccgggtgc ggtggctcac gcctgtaatc tcagcacttt gggaggccga 2575 tgcaggcaaa tcacctgagg tcaggagttc gagaccaacc tgaccaacat ggagaaaccc 2635 catctctact aaaaatataa aaattagccg ggcgcggtgg tgggcacctg taatcccagc 2695 tgcttgggag gctgagacat gagaacggct tgaacccggg aggcagaggt tgcagtgagc 2755 cgagatcgtg ccattgcact ccagcctggg caacagaatg agactccacc tcaaaaaaaa 2815 ataagtaaat aaataataac aacaataata ataatcaaag caggaattac tgactgaatg 2875 accccaaccc caccagatgg tgacaagcac aatactcttg gacagctggg aattggtgga 2935 tttgggattt gaatcctctg tctaaccctg gccctgccct gtgggattct ctgccacggc 2995 aaagaagggg gttgtgggtg atggcaggtg tctttggtgg gttaacagca tcgtcatcag 3055 acagtgagga ggacccagaa gccttggaga agcagaagaa agtgcggccc atgtacctga 3115 aggactacga gaggaaggtt atcttggaga aggcagggta tggagaaggc ctacatcccc 3175 accccctggt tcccagccct gtcaggtcta tgggggtctt aggggcagga gagggaaaaa 3235 agctggcagc ctgggccggg catggtggct catgcccata atcccagcac tttggtaggc 3295 tgaggcaata ggatcgcttg aggacagaag tttgagacca ggctgggcaa cataccccgc 3355 ctctacaaaa aaattaaaaa ttagctgggc atgatgatgt gtacctgtag tcccagctac 3415 tcaggaggct gaggcaggag gattgagcca ggagatggag gctgcagtga gctatgatca 3475 ggccactgca ctccagcctg ggcaacagaa taagaccctg tctcaaaaag aaaaaaggcc 3535 gggcatggtg gctcatgcct gtaataccag caccttggga ggctgaggcg ggcagatcac 3595 ctgaggtcaa gagtttgaga ccaccctggc caacatggtg aaaccccgtc tctactaaaa 3655 atacaaaaat tagccagatg tggtggtggg cgcctgtagt cccagctacg tggggaggct 3715 gaggcaggag aatcgcttga atctgggagg tggaggttgc agttttccga gatcatgcca 3775 ctgccctcca gcctgaggga tagagcgaga ccctggctca aaaaagaaat gctgtcaccc 3835 atgattggaa aag 3848 <210> 44 <211> 6777 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (4776)..(5177) <400> 44 tgtgcactga gggcccacca cgcattggca gaggggctgg gctaggggag ctgcctgggt 60 ggctgcatgg gctcagctgt ccttttgatt ttcagattcg tctgcggtgc caaaagggca 120 tcccgccttc tctgcggggc cgtgcttggc agtacctgtc aggaggcaag gtgaagttac 180 agcagaaccc tggaaagttt gacgtaagtt tcccttcctt tgccctgccc tcccttccgc 240 atctcttgtg tcctccccat ggcggcaatc ctccatgtgc tcgcctgaac ctcacaggat 300 gagcagtcca tgaaacctcc agtcatgtgc ccaactgccc aggccccagc aggccagacc 360 ggcccagtcc tgggtacctg tgtctcctgg agggtctgta caactgaggc tccagccctg 420 agcagccctc agtggaatgg ccagatttgg taccccctat tccagctctt tctcttgatg 480 accactcagg ttttgctttc ctgggctcag taggctacct ccctgctctt ggtcatcagg 540 aggggacact cagaccattt ccctgactgc cttgggccct gtgccctggg cctatggggg 600 cttgactagc aggaccacag gtccttcagt gtctcccggc ctcccatcct ctactttctc 660 ctgccttgtc caagcctggc cagcacagcc cacctgtgtg tcttgtgggg tcatcagccc 720 taggagtagc agagccaaac ccaagggggc tgaagggaac tgcccaagta gctcaagggg 780 tcagacgcca gtcagtggcc agagagggtg ccctctgttg ttatccctcc tcctgtcccg 840 atatccctcc tgctgctccc tgccccatgg ctggccagag taaaatacct ctccattcag 900 agctgggcgg ctcctccagc ctgctccccc agggaactat ggggaagcag ttggattccc 960 tggggttgcc ccggcttacc tgccagatct ggccgcaggc atcggggttt ctcgcaggcc 1020 cttgggactg gtgacaggca gacagtgaga cagagcagag ctgcctgcca ccagctcttt 1080 gttgacatat ctcatgcttc ttcattgaac actccagtct tgccaaacct gttccttgag 1140 atgactgggc aggagcaggg caaggtagcc tagagtttct gctgttgacc tggagagggc 1200 gagagccttt tgctggcaac acgtggactt gcaggggcag ggaagctggt agagtgtctg 1260 gctggggtag gtctgaatct ggctgattgg attattcccc agagcaccaa taccaggcca 1320 cactggagca gcctcttgac tccagagtct tcctcctagt ggctacatct cttccatttc 1380 gaggggccgc atcctgggca aagtgggagg ctcaggggtg ggaacctcag tccaagtcca 1440 tagttaaaat caggctgcca gagccaggca tgagagccaa gagcgtgggc agcctggtca 1500 gcctcttggc tgtgtggttc agcaagcatg agtgtgtgtg cagcagaaca cagagctgtg 1560 tgcatgtgtg tgtagagctg tgcttccaga gaagaatcag ccacccccca gggggtctgg 1620 aaagttgctt gtgtgaggag gtggatttgc agagagggcc ttcttgatgc accgaagctg 1680 agtgacgggt tcctgcatgg ttctgggggc tggaagaatg gtttgtgagc acacctggaa 1740 agactttgcc tgtgggtgac ccagaggaag catgaggagc ttcccctggt tgctgcgggt 1800 cctgtgccga ggcagggcac agtgggggtc tggtgatggc agcatgcacc tgtttctgtg 1860 ctctctcccc acagggccct ccattcaata cccagtccag gtggcccatc ccaacctcag 1920 cattcagggc aggctctgca ggtgctggtg gctccttctc ctgcacgtgc tatttcttcc 1980 tccttccttg ggcaggcagg acctcctgtc cttttttacc tggctttctt ctctggcttc 2040 accttatgat ggcaccagta cccctcaggc tggtggaggc tacaggcccc atgaccatgg 2100 tacctgcttg tctgccggtg ccctttcgat ctgcagctac cctcttttcc tttctcacca 2160 accatgtgtg gccaagtgcc ttaggctgct gaagtgccag atgaacacat cctaggaact 2220 gacttccggg gttttcgggt tcctacctca tgggaactgc taggagaatt tgtggggccc 2280 tcttccccat tctgacaaaa gcaaacctgc actgcgctca gacagtactt agaggtgcac 2340 agtacacaga cccccatcac aagggtgtgt ggggccccag aggcacgcat ccaccgctcc 2400 gctatgtgcc tgctctgggg ctctgtgtgg aggccccagc ccctccctgt cccctccagc 2460 cctgaacact ctgtcagccg ctcctctcag tccttaccct ctagtcaagt tcctggcacc 2520 ctaggttctt gagcttaatg ctaggacact cccactgagg gccagagagg gaaaggggct 2580 tgtatgaagt cacctgctcg tcagggcagg gcctgtgtct gcgcccactg ggtatgtttg 2640 ctgaggacct ggcctccctc ctgagggcct tccctgatgc tgcccctgcc ctgcaggcaa 2700 cttgtactta aaccaacact cccatgaagg tgcctgggcc acacctttca gcacattctg 2760 gttcctctgg tgaatactct gcttccctgc tcagccctct gggcttcctc cttatttatt 2820 ttttctttct tttttaaaaa ttgaggtatg aatttacata cagtaaaatg catagatctt 2880 gaatgtgcat gcagttcagt gagttttgat aaataataca catccatgta accaacatgc 2940 agatcaaggt agagaacatt tcaaatgacc aagaaaagat tttccttttt gtaatggctt 3000 tgttgttttg taaaggtgca catactgaag cgttcacaga agttcaaaga aaagagtaaa 3060 actttgttga aacctcggca cccagagaag tatctgaggt taatggtttg acagatgtca 3120 tgtccttcca gaaagagctc tgtgcagatc tcacacacac ctggcttcct ggatagttga 3180 cgccacctgc acagggaggc atgtagctga ggagctggga tggacggctt tgagtcagac 3240 ctggcttcca gtcccagctc caccattttt ctagccagag taaaatacct tgacatgagg 3300 ccttgacatt cagttttctc atctgcgaac aggatgtaat gataggtcct atctctggag 3360 gttggggagc aggatcagta aggcccacag gtaccctgtg cccagcttag cgcctggctc 3420 agagaagtgg gaacagctgg tagctattgc tcagagaagc agccttctgt cttaaggatg 3480 tgacataatg tatctgactc ccgaatgaaa tgtctagagg tccttccagc cgcagctgga 3540 gtggacactc ttgccctcat cggtcttcct agagccaggt ttaaggtttc cagggccctt 3600 ccctccttgc ccctttgccc ctgcccaggc attccttacc tgagcttctc ttcctgtcct 3660 tgggaaggcc cagtctgtga tgggcttggg tgggcactgc ccctggtgga gggccccctc 3720 ccctaatccc tgggcagccg tgtcctgtca gcaaagccca cctccatcct ccccagcccc 3780 taatttgtgc ccttgcttct aggagctgga catgtcccct ggggacccca agtggctgga 3840 cgtgattgag cgtgacctgc accggcagtt cccattccat gagatgtttg tgtcccgggg 3900 gggccacggc cagcaggacc tattccgtgt gctgaaggcc tacacgctgt accggcccga 3960 ggagggctac tgccaggccc aggcgcccat tgccgctgtc ttgctcatgc atatgcctgc 4020 tgagcaagcc ttctggtgcc tggtacagat ctgtgagaag tacctgcccg gctactacag 4080 cgagaaactg gtgagtgtcg cctggcctgg gacttgccct gggctggaca ccctctgtgg 4140 cccctccagg cccttctctc atagtaactc ctgcccaggt taaaaacttt ccggccttct 4200 gttgccttga ggctgaagtc ccaaggcctg ccagggttag gtctcctggg ttacaatgtt 4260 atcccttcta cactgacttt catctcagcc tctagctgct ctggtcactt tgcagaattg 4320 aagttcttcc agggcaccaa gttcttccct cccttcgcct tggccttgtc ctaggctaaa 4380 atctgcttgg aagctccctt ccccgtgctg tcccctaaaa acttctcttg tccttcagct 4440 tttagccctc agggagcttc cttgaccctg acaggcgaga ccctccagca catgcttgag 4500 agcagtcctg ctccagcctt gttaggggca ttcagcctcc tccccctccc ctagcctctt 4560 ttgctcatgt gcccttctca ggataagctc cctccagggg accagctggc tccgctttgc 4620 tcatcattgt atcctagcac ctggcagagg cagacaccct gcaggcggta gctgcctgag 4680 cctgctgggt gctgggtgct gggtgctggg gtgtagtctc tgccctggct cctgcagccc 4740 acggtcatgg tcccgtggcc tcgatgtctc cctag gag gcg atc cag ctg gac 4793 Glu Ala Ile Gln Leu Asp 1 5 ggg gag atc ctt ttc tcg ctg ttg cag aag gtg tcg ccg gtg gcc cac 4841 Gly Glu Ile Leu Phe Ser Leu Leu Gln Lys Val Ser Pro Val Ala His 10 15 20 aag cac ctc agc cgt cag aag atc gac ccg ctc ctc tat atg aca gaa 4889 Lys His Leu Ser Arg Gln Lys Ile Asp Pro Leu Leu Tyr Met Thr Glu 25 30 35 tgg ttc atg tgc gcc ttc tcc cga acc ttg ccc tgg agc tct gtg ctg 4937 Trp Phe Met Cys Ala Phe Ser Arg Thr Leu Pro Trp Ser Ser Val Leu 40 45 50 cgt gtc tgg gac atg ttc ttc tgt gaa ggg gtc aag atc atc ttc cgg 4985 Arg Val Trp Asp Met Phe Phe Cys Glu Gly Val Lys Ile Ile Phe Arg 55 60 65 70 gtg ggg ctg gtg ctg ctg aag cac gcg ctg ggc tcc cct gag aag gtc 5033 Val Gly Leu Val Leu Leu Lys His Ala Leu Gly Ser Pro Glu Lys Val 75 80 85 aaa gcc tgc cag ggc cag tac gag acc atc gag cga ctg cgg agc ctc 5081 Lys Ala Cys Gln Gly Gln Tyr Glu Thr Ile Glu Arg Leu Arg Ser Leu 90 95 100 agc ccc aag atc atg cag gag gcc ttt ctg gtc cag gag gta cag ccc 5129 Ser Pro Lys Ile Met Gln Glu Ala Phe Leu Val Gln Glu Val Gln Pro 105 110 115 atg cct gcc cct tat cat ggg gag gga gga aga cag gtg ggg gtc ctt 5177 Met Pro Ala Pro Tyr His Gly Glu Gly Gly Arg Gln Val Gly Val Leu 120 125 130 tgaagggggt cccgctaacc ctcagcccct gagggtggat cctatgccag gaccattgct 5237 aggcaacaca gaacatgtgg gtggacctca tccttctgtc tggtgaagag catggggcac 5297 agagaggctt ggctctgcag ggccttctgg atccgagccg cttgggaatg aagaagaatg 5357 ttgacccacg gccccgtctt cctccctggt accccattcg cagccttggc tcttatttct 5417 ctttgttctt tctttatgga tacttgtctc tcaggggcaa ttaggtggaa catgcgtgac 5477 cagcttttac acatgaggaa atggaggctc acagaggcag aatcactaag caactcccct 5537 taaagtcacc cacccaggtg gagctggaat ttgagcctaa gcagccaggc tgccctgggc 5597 agcggtgggt gacaggttgg cagagagcag gtttttgtct gtctgggtct taccccttta 5657 gccccatagt caggcaggtg gactcgtgaa gctgtgggca gctttatcct ctgaggcggt 5717 gggtctcaag tgtccagctc acctggcact cagctgtggg gctcgtgact gcagcttggg 5777 actagaccct catccttcct ggggtcagtg tttagtggcc aaggctgggg gatgctgagg 5837 aagactgggg gcccaggctg ggaggcagaa ggggaaggtc cttcttcttg gtgtccactt 5897 gcctgtgtca ctgcccctgc aggtggtgga gttgcccgtg acagagcgcc agattgagcg 5957 cgaacacctc attcagctgc ggcgctggca ggagacccgg ggtgagctgc agtgccgctc 6017 cccgcccagg ctgcatggtg ccaaggctat cttggatgca gaacctggtc cccggcctgc 6077 cctacaacct tcaccatcca tccacctgcc cctagatgcc cccctccctg gtccaaagcc 6137 aagcccaagc cacccaagca ggcccagaag gagcagcgga aacagatgaa ggggagaggg 6197 cagctggaga agcccccagc cccaaatcaa gccatggtgg tggccgctgc aggagatgca 6257 tgtcccccac agcatgtgcc cccgaaggac tcagccccca aggactcagc ccctcaggat 6317 ttggctcccc aggtctcagc ccaccaccgc tcccaggaga gcttgacgtc ccaagagagt 6377 gaggacacct acttgtaacc ctggcagcta aggcctccag ggcggggtct ccatataact 6437 acacggttca tgaactgaca ttccacatcc tgcccaccct ctgagggcca agctgcctgg 6497 ccactgggct gggctggagt ctggctggtc caacacagat tctgcctggt ccaacacaga 6557 ttctgcctga gcctccttat ttattttctt tacagtggca ctcaggctgg cccagccagg 6617 gcaggcagaa gctagggcct ggggggtggg gcctccttca gccccctcct cctgggggat 6677 gctccccagg gttagggtgc tggtgtgagg ggaaagggtg gggtgttctt tgtgtaaaat 6737 agaaacatgg ttttgtacag aaataaacag ccttgtatag 6777 <210> 45 <211> 7119 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2329)..(5094) <400> 45 gggctctggg accgcagttg ctgaaatgga ggcagaggtg tgggaggcag aaggctacaa 60 cctagttctg gactcggacc tgtatgatgc ggatggctat gatgtcccag accctgggct 120 gctcaccgaa aagaatgagt tgactttcac ggagccgtcg caggtcctgc cctttttgac 180 cagcagccaa cagtggcaaa gcctgacccc gcgcgcccgc gcccgccggc tgtggctgct 240 tctgcgcacc agcctccacg aagtcgtgga aaaggagaag agagccgagc tgcgcgcggc 300 gcgcctgacg catgggctgg aaccactgcg ccgcctggag gtggcagccg ggctgcgctc 360 ggtggcgcag gacccggtgg gtggacgctt cgtggtgctg gacggcgcgg gccgcctgca 420 cctgcacaag gaagacggct gggcacagga gacgctgctg gcgcctgtcg ggcttacggg 480 gctggtgacc gtgctgggcc cgctgggtgc cgtgggccgt tttgtaggct ggggccccgc 540 ggggctggca attctgaggc ccaacctcag cctgctgtgg ctgagcgagc agggggtggg 600 cagggccccg ggttgggcgc ccacctgctg cctgccggtt cccgacctca ggctgctgct 660 cgttgcggag atgaacagca gcctggcgct ctggcagttc cgctcaggtg gtcgccgcct 720 ggtgctgcga gggtcagcac tgcacccgcc cccgagccca acaggcaggc tcatgcgtct 780 ggctgtggcg ccggttcctc cccaccacgt cctgcgctgc ttcgcggcct atggctcggc 840 cgtgctcacc ttcgatctgc atgcctggac tctcgtagat gtgcgccggg atttgcacaa 900 aaccaccatc tcggacctgg cttactgcga ggaagtagag gcaatggtga cagcttcccg 960 ggacagcacc gtgaaggtgt gggaggctga ctggcagatc cggatggtgt tcgtgggcca 1020 cacaggcccg gtgacggcta tgactgtgct cccgaacacg accctggtgt tgtcggcctc 1080 gcaggacggg acgctacgca cctgggacct gcaggcggcg gcgcaggtgg gcgaggtagc 1140 gctgggcttc tggggccagg acaagctgtc ccggcgcgtg ggccgtctgc tggcgccggt 1200 gcgcccgggc tggccggtgc tgtccctgtg cgcgagcagc atgcagctgt ggcgcgtacg 1260 cgagctctac tcgccgttgg cgcaactgcc cgccaaggtg ctccacgtgc agttggcgcc 1320 cgcgttgccc gcgcctgcgc accagtcgct gcctacgcgc ctcgtgtgcg cgtgcgccga 1380 cggctcggtc tacctcctgt cggctgccac cgggcgcata gtgagctcac tgctgctgga 1440 gccggaggac tgcgcggcag ccgtggccta ctgcctgccg cgcgaggcgc tgtggctgct 1500 gaccagggct gggcacctgg tccgcgccaa cgcggcgcgc tgccccatga gcgtgctgca 1560 ccgcgtgtgc ccgccgccgc cccctgcgcc gcagccttgc tgtctgcacc tgtacagcca 1620 cctcacggat ctcggaggcg ccttctcctc ctgggagatc gtgcgccagc actggggcga 1680 gttgcgctgc agctctgtgg cctgcgcctg gaagaacaag aaccggtacc tgccagtggt 1740 ggggcacacg gacggcacgc tgtcggtgct ggagtggctc tcgtcgaaga ctgtcttcca 1800 aacggaggcg cacagcccgg gcccggttgt cgccatcgca tccacctgga acagcattgt 1860 gtcttcgggt ggggacctga cggtgaagat gtggcgcgtc ttcccctatg ccgaagagag 1920 cctgagcctg ctgcgcacct tctcctgctg ctacccggcc gtggcgctct gtgcgctagg 1980 cagacgcgtc accgcgggct ttgaggaccc agacagcgct acctacggcc tggtgcagtt 2040 tggcctgggc gacagtccgc gattagacca ccggccccag gacgacccca cggaccacat 2100 cactggcctg tgctgctgcc ccacgctcaa actgtatgcc tgctccagcc tggactgcac 2160 cgttcgcatc tggactgctg agaaccgcct cctgcggctc ctgcagctga atggtgcccc 2220 tcaggccctg gctttctgca gcaacagtgg agacctggtg ctggcgctgg gatcccgcct 2280 ctgcctggtg tcccacaggc tctacctgcc tacatcctac ctagttaa gaa gat gtg 2337 Glu Asp Val 1 ccg gaa ggc ccc aga cgt ggt gga cga ccc tcc gct gcc act gat gag 2385 Pro Glu Gly Pro Arg Arg Gly Gly Arg Pro Ser Ala Ala Thr Asp Glu 5 10 15 cca gga gtc act gac ttc cgc cca act gca gag gct cac caa cct cca 2433 Pro Gly Val Thr Asp Phe Arg Pro Thr Ala Glu Ala His Gln Pro Pro 20 25 30 35 tgg ggc agc cag cct cag gtc cca tgg agg cct gct cag ccc tcc tgg 2481 Trp Gly Ser Gln Pro Gln Val Pro Trp Arg Pro Ala Gln Pro Ser Trp 40 45 50 agg ccc tcc ttt ccc act ctg ggt ggg ggc ctg gcg gtg tgg ggc cct 2529 Arg Pro Ser Phe Pro Thr Leu Gly Gly Gly Leu Ala Val Trp Gly Pro 55 60 65 ctg gag ttg ata caa gcc tgc ctg agc cct ggc aca ccc gtt tgg ggt 2577 Leu Glu Leu Ile Gln Ala Cys Leu Ser Pro Gly Thr Pro Val Trp Gly 70 75 80 tgg tcc ttg tcc cag cct ctg ccc cag ccc act ggc atg cca ccc agc 2625 Trp Ser Leu Ser Gln Pro Leu Pro Gln Pro Thr Gly Met Pro Pro Ser 85 90 95 atc cca cct gtg cct gtc cct gtt tgc agc gag gcc ttg tct ctc atc 2673 Ile Pro Pro Val Pro Val Pro Val Cys Ser Glu Ala Leu Ser Leu Ile 100 105 110 115 cat cgt cgg agg gca aca tct cag cac ctg gtg ccg aag gag gac ttg 2721 His Arg Arg Arg Ala Thr Ser Gln His Leu Val Pro Lys Glu Asp Leu 120 125 130 gac gcc ata gtg gcc cgg gac cga gac ctt cag cag ttg agg ctg ggg 2769 Asp Ala Ile Val Ala Arg Asp Arg Asp Leu Gln Gln Leu Arg Leu Gly 135 140 145 cta gtg gtc cca gca gcc cag ccc cca ccc tcc tgg cag cag cgc cag 2817 Leu Val Val Pro Ala Ala Gln Pro Pro Pro Ser Trp Gln Gln Arg Gln 150 155 160 gaa ggc ttt gac aat tac ctc cgt ctg atc tac ggc tct ggc ctg ctg 2865 Glu Gly Phe Asp Asn Tyr Leu Arg Leu Ile Tyr Gly Ser Gly Leu Leu 165 170 175 ggc atg cag tct gga agg ggg tcc cag cag tgg agt gcc ggg acc ctc 2913 Gly Met Gln Ser Gly Arg Gly Ser Gln Gln Trp Ser Ala Gly Thr Leu 180 185 190 195 aga gtg gag aga gag acc cgg gat gtg tgt gct gta ccc caa gct gcc 2961 Arg Val Glu Arg Glu Thr Arg Asp Val Cys Ala Val Pro Gln Ala Ala 200 205 210 cac tgt ctt gcc cgg gct gag gtc agc act gca gcc caa aca gtg cca 3009 His Cys Leu Ala Arg Ala Glu Val Ser Thr Ala Ala Gln Thr Val Pro 215 220 225 aca gcc ctg tcc cca cag gac ctg gga gcc ctg ggc cag cac ttc tcc 3057 Thr Ala Leu Ser Pro Gln Asp Leu Gly Ala Leu Gly Gln His Phe Ser 230 235 240 cag tct ccc cga gtc aca gtg ccg atc cca ccc acc cac cgt agg gtg 3105 Gln Ser Pro Arg Val Thr Val Pro Ile Pro Pro Thr His Arg Arg Val 245 250 255 cac agc aag gca tcc cag ctt ctg gcc cgc tcc tca ctg agc cac tac 3153 His Ser Lys Ala Ser Gln Leu Leu Ala Arg Ser Ser Leu Ser His Tyr 260 265 270 275 ctg ggc atc agt ctg gat ctg cag ctg cag ttg gag cag ctc cga ggg 3201 Leu Gly Ile Ser Leu Asp Leu Gln Leu Gln Leu Glu Gln Leu Arg Gly 280 285 290 agg acg acc atg gcc ctg gac ctg cca tcc tcc cac ttg cag tgc agg 3249 Arg Thr Thr Met Ala Leu Asp Leu Pro Ser Ser His Leu Gln Cys Arg 295 300 305 atc cca ctg ctg cca aag aga tgg gac aag gaa cct ctc tct agc ctc 3297 Ile Pro Leu Leu Pro Lys Arg Trp Asp Lys Glu Pro Leu Ser Ser Leu 310 315 320 agg ggc ttc ttt cct gcc acc gtg cag ccc cac aag cac tgc ctg agg 3345 Arg Gly Phe Phe Pro Ala Thr Val Gln Pro His Lys His Cys Leu Arg 325 330 335 ccc atc tgc ttc ccc ggc tat gtg ccc aac tcc gcg gtg cta cag cag 3393 Pro Ile Cys Phe Pro Gly Tyr Val Pro Asn Ser Ala Val Leu Gln Gln 340 345 350 355 atg tgg cta aat gcg gag cca ggg gca agc cag gat gcc ctg tgg ttg 3441 Met Trp Leu Asn Ala Glu Pro Gly Ala Ser Gln Asp Ala Leu Trp Leu 360 365 370 tgg cgc ccc agg cca tcc caa gcc cag tgg cag agg aag ctg ctc caa 3489 Trp Arg Pro Arg Pro Ser Gln Ala Gln Trp Gln Arg Lys Leu Leu Gln 375 380 385 tgg atg ggg gag aag cct ggg gag gag ggg gag gaa gac aag aag gaa 3537 Trp Met Gly Glu Lys Pro Gly Glu Glu Gly Glu Glu Asp Lys Lys Glu 390 395 400 gag gag gag gag aag gaa gac gag gag ctg gac tgg gcc ttg gct tcc 3585 Glu Glu Glu Glu Lys Glu Asp Glu Glu Leu Asp Trp Ala Leu Ala Ser 405 410 415 ctg agc ccg cac tcc aac cag cag ctg gat tcc tgg gaa ctg gag gat 3633 Leu Ser Pro His Ser Asn Gln Gln Leu Asp Ser Trp Glu Leu Glu Asp 420 425 430 435 cag agt gct gtg gac tgg acc cag gag ccc cgg cgg cgc agc tgc aag 3681 Gln Ser Ala Val Asp Trp Thr Gln Glu Pro Arg Arg Arg Ser Cys Lys 440 445 450 gtt gcc agg acc cac cct cat ccc tgg cac cgt cat ggg agt ttg ctc 3729 Val Ala Arg Thr His Pro His Pro Trp His Arg His Gly Ser Leu Leu 455 460 465 ttg gat gag cat tac ggg cat ctg ccc aag ttt ctg cat ttc ttc atc 3777 Leu Asp Glu His Tyr Gly His Leu Pro Lys Phe Leu His Phe Phe Ile 470 475 480 tac cag acc tgg ttc aaa aag ttg ttc ccc atc ttc agc ctg cag gca 3825 Tyr Gln Thr Trp Phe Lys Lys Leu Phe Pro Ile Phe Ser Leu Gln Ala 485 490 495 tac ccg gag gcg ggc acg atc gag ggc ctg gcc tcg ctg ttg gtg gcc 3873 Tyr Pro Glu Ala Gly Thr Ile Glu Gly Leu Ala Ser Leu Leu Val Ala 500 505 510 515 ctg ctg gag aag acc acg tgg gtc gac cgt gtg cac atc ctg cag gtg 3921 Leu Leu Glu Lys Thr Thr Trp Val Asp Arg Val His Ile Leu Gln Val 520 525 530 cta ctg aga ctg ctg ccc aac atg agc agt gat ctc caa ggc cag ctg 3969 Leu Leu Arg Leu Leu Pro Asn Met Ser Ser Asp Leu Gln Gly Gln Leu 535 540 545 cag ggc ctg ctc gta cac ttg ctc aac ctg gac cag ccc ccc agc ctc 4017 Gln Gly Leu Leu Val His Leu Leu Asn Leu Asp Gln Pro Pro Ser Leu 550 555 560 cag gac cag aca cag aag aag ttc gtg ata ctg gcg ctg cag ctg ctc 4065 Gln Asp Gln Thr Gln Lys Lys Phe Val Ile Leu Ala Leu Gln Leu Leu 565 570 575 ctg gcc tgc tcc ctg gag tcc cgg gat gtg gtg ctg gag ctc atg tcc 4113 Leu Ala Cys Ser Leu Glu Ser Arg Asp Val Val Leu Glu Leu Met Ser 580 585 590 595 tac ttc ctc tac tct ccc gtg cac tgc cgg cca gag ctc aag aag ctg 4161 Tyr Phe Leu Tyr Ser Pro Val His Cys Arg Pro Glu Leu Lys Lys Leu 600 605 610 ctg cac ggg ctg ggc ctt cag gac cca gag ggc ttc cta ttc aag gag 4209 Leu His Gly Leu Gly Leu Gln Asp Pro Glu Gly Phe Leu Phe Lys Glu 615 620 625 atg atg acc tgg gtc cag ggc cca gac ctg gac tcc aag gcc ggc ctg 4257 Met Met Thr Trp Val Gln Gly Pro Asp Leu Asp Ser Lys Ala Gly Leu 630 635 640 cgc act tgc tgc cac cag aaa ctg gag gac atg atc cag gag ctt cag 4305 Arg Thr Cys Cys His Gln Lys Leu Glu Asp Met Ile Gln Glu Leu Gln 645 650 655 gag acc cca tcg cag acg tca gtg gtc tct ggg gca ccc aca cgc gcc 4353 Glu Thr Pro Ser Gln Thr Ser Val Val Ser Gly Ala Pro Thr Arg Ala 660 665 670 675 tcc gtg ata ccc tcg ggc acc tcc tgg tcg gcc tcc ggc atc ttc ggg 4401 Ser Val Ile Pro Ser Gly Thr Ser Trp Ser Ala Ser Gly Ile Phe Gly 680 685 690 agg ctc tcg cag gtc tca gag gtg cct ttg atg gtg gtc tca cct gcg 4449 Arg Leu Ser Gln Val Ser Glu Val Pro Leu Met Val Val Ser Pro Ala 695 700 705 gag ccg cac tct tta gcc ccg gag ctc cag gcc cag cgg atg ctg gca 4497 Glu Pro His Ser Leu Ala Pro Glu Leu Gln Ala Gln Arg Met Leu Ala 710 715 720 ccc acg cgc agc tgg ggg acc cct cag ctc cgt ctc aga gtg ctc tcc 4545 Pro Thr Arg Ser Trp Gly Thr Pro Gln Leu Arg Leu Arg Val Leu Ser 725 730 735 gag acg ctg aag agc ttc tgc ctg gag ccc gag gcc cgc ctg cac cct 4593 Glu Thr Leu Lys Ser Phe Cys Leu Glu Pro Glu Ala Arg Leu His Pro 740 745 750 755 gcc ggg cct gct cag ctg ccc gga gag ccg ccg ccg ctg gag gag acc 4641 Ala Gly Pro Ala Gln Leu Pro Gly Glu Pro Pro Pro Leu Glu Glu Thr 760 765 770 gac tgg tcg cac tcg cag ctg ctg gac ttg ggc ccc atc gac gcg ctc 4689 Asp Trp Ser His Ser Gln Leu Leu Asp Leu Gly Pro Ile Asp Ala Leu 775 780 785 aac ttc ttc tgt gag cag ctg cgg gcg cag cag cgg agt tcg ctc cag 4737 Asn Phe Phe Cys Glu Gln Leu Arg Ala Gln Gln Arg Ser Ser Leu Gln 790 795 800 gag aag gct gcg cac cca cac ccg cca gtg ccc tac acg gtg gcg ccg 4785 Glu Lys Ala Ala His Pro His Pro Pro Val Pro Tyr Thr Val Ala Pro 805 810 815 gtg ccc gac atg gtg gtg cca cct ccg cgg gag cac tgg tac cac ccc 4833 Val Pro Asp Met Val Val Pro Pro Pro Arg Glu His Trp Tyr His Pro 820 825 830 835 atc ctc cgg ctg cag gag gcc aag ccg cag agg tcc gcg agg tcc gcg 4881 Ile Leu Arg Leu Gln Glu Ala Lys Pro Gln Arg Ser Ala Arg Ser Ala 840 845 850 atg aga ctg agg ggc ccc atg ccg tcc cgg ctc tgt gcg ggc cgc acc 4929 Met Arg Leu Arg Gly Pro Met Pro Ser Arg Leu Cys Ala Gly Arg Thr 855 860 865 ctg gac ggc ccc atc cgg acg ctg aag ctg ccg ttg ccg cgt gtg gag 4977 Leu Asp Gly Pro Ile Arg Thr Leu Lys Leu Pro Leu Pro Arg Val Glu 870 875 880 ccg cag cct ttc ccc ctg gac tgg cct atg ccc ccg cgc ccg ctg ccc 5025 Pro Gln Pro Phe Pro Leu Asp Trp Pro Met Pro Pro Arg Pro Leu Pro 885 890 895 ccg cgg ctc ctg cag ccg gcc ctg cag cgc tac ttt ctg cca gcg gac 5073 Pro Arg Leu Leu Gln Pro Ala Leu Gln Arg Tyr Phe Leu Pro Ala Asp 900 905 910 915 gcg gac cct gac acc tac agc tgaccgggct ggtggcctca gcccgcctgg 5124 Ala Asp Pro Asp Thr Tyr Ser 920 ctctggggcc tgtcattggt atttggccaa ggcctgcatc gggaataaag tccagagaat 5184 ttctttctgc aggatgccgc ctgctttgga gggccccggg gtgcgcacgg cgtgtgggcg 5244 tgcggcctga acccacagtg gcggcggaag gcaggagccg gaggcctggc ggaggtggcc 5304 atcgtgggca ccagcgttcc cggaggggtg gccggcctag ggcagaggag acccatagcg 5364 gggtaccatc cgctgggcac tgagcaaacg ttttctgctc aagtactagg tgttgagatg 5424 cgggctgacc ttagagaacg tgtcctgggc cagcccacag cctggtgtgg aggggagtcc 5484 gggagggcct gggcggtccc aggatgagcc ttccgggtcg atgcaggtga gaccaggagt 5544 ttgcagacct tgctttcgtt acttttattc tggaaaagag aagaattgac aaaggcacca 5604 ggagcttttt tctgagcggc aacgcagagc atcctctgac ccctttagcc tgaaagtccc 5664 taggggaggg gcttggtccg gaagggctcg gcctctgggc cgggctcctc tgccctgtgt 5724 ggcctggcag ggcgcaagac ctgtgcacag agttcttggg gcagctctgg ggggaatccc 5784 cggcttttac acctgtcttt tgtgttgtct gagcagtgat ttccctcctg tatctgtagc 5844 ctctgacttt actagtttct tcttgatggc tctggttaga atcgcttctc cacaccttcc 5904 ctgtcacccc aaactgtgcg gtggctcttg ttatggggcc accaaatggc tgctctttcc 5964 caggccggtg cttgacacag tggtgccacc atcccaagag catgggtgcg caggaccgtg 6024 cgggacagcc aagttgctgg gcccagctga acctgcctct tcacctccag gcactaccgc 6084 atcctcccac tgcagaaggc caaggttcac aggtgtgcga tgagactgag gactgagtct 6144 gtcactagag gacttgacac tttttataaa aaaaatgagt aaacctagat acctcgatca 6204 gtgtctagcg atgtcaaggc ccccagtttg ggttcaagcc tgctgggaca gtcctgcagc 6264 tgctgggtca cagagtggcc aaggccctct gatttttggt caggacacag aaagatagca 6324 gggggcaggg ggggatctga gggaccccac atgacttaca atcagacaag gtaggtcaga 6384 ggatttcttt atggctatct gttttgtttt gttttgtttt gttttgtttt ttgggatgga 6444 gtttcggtct tgttgcccag gctggagtgc agtggcgtga tctcggctca ctgcaacctc 6504 tgcctcccgg attcgggcga ttctccttcc tcagcctcct gagtggctgg gattgcaggc 6564 gtgtgccgcc acgcccggct aattttgtgt ttttggtgga gatggggttt cgtcacgttg 6624 accaggctgg tctcgaactc ctggcctcag gtggtccgcc tgcctcagcc tctcaaagtg 6684 ctgggattac aagcgtgagc cactgtgccc agccttcttt atggctatct ccaagacagc 6744 aaaggcaggg gaaagtcctg ccttggggag aaaaaggagg gtgggaaaag gtcaaagaga 6804 aagatgctgt tgtctgagtc ttgcctctga ggcctaagtt ccccaacatt ataacaaggg 6864 atatgggagt tataagccag gaactgtgga tggaaaccaa tgacagatat cataatatca 6924 cacccacaca tcaggcaaga gacttgttcc ttaaaaatta tctagtttag ccgagcgtgg 6984 tggctcacgc ctgtggtccc agctgcttgg gaggctgagg caggagaatc acttgaaccc 7044 aggaggtgga ggttgcagca ggcagggatc acaccactgc actacagcct cggcaataga 7104 gcgagactct gtgtc 7119

───────────────────────────────────────────────────── フロントページの続き (72)発明者 中島 大輔 千葉県木更津市矢那1532番３号 財団法人 かずさディー・エヌ・エー研究所内

Claims (5)

【特許請求の範囲】
1. 【請求項１】 以下の（ａ）又は（ｂ）のポリペプチド
   をコードする塩基配列を含むＤＮＡ： （ａ）配列番号：１乃至４５（但し、配列番号７、１６
   及び２６は除く）のいずれか一つで示されるアミノ酸配
   列と同一又は実質的に同一のアミノ酸配列から成るポリ
   ペプチド、 （ｂ）配列番号：１乃至４５（但し、配列番号７、１６
   及び２６は除く）のいずれか一つで示されるアミノ酸配
   列において、一部のアミノ酸が欠失、置換又は付加され
   たアミノ酸配列から成り、（ａ）のポリペプチドの機能
   と実質的に同質の生物学的活性を有するポリペプチド。
2. 【請求項２】 以下の（ａ）又は（ｂ）のＤＮＡ： （ａ）配列番号：１乃至４５（但し、配列番号７、１６
   及び２６は除く）のいずれか一つで示される塩基配列に
   おいて、夫々の配列で示されるアミノ酸配列をコードす
   る塩基配列を含むＤＮＡ、 (ｂ）（ａ）のＤＮＡとストリンジェントな条件下でハ
   イブリダイズし、（ａ）のポリペプチドの機能と実質的
   に同質の生物学的活性を有する蛋白質をコードするＤＮ
   Ａ。
3. 【請求項３】 請求項１又は２記載のヒトＤＮＡを含む
   遺伝子。
4. 【請求項４】 以下の（ａ）又は（ｂ）の組換えポリペ
   プチド： （ａ）配列番号：１乃至４５（但し、配列番号７、１６
   及び２６は除く）のいずれか一つで示されるアミノ酸配
   列と同一又は実質的に同一のアミノ酸配列から成るポリ
   ペプチド、 (ｂ）配列番号：１乃至４５（但し、配列番号７、１６
   及び２６は除く）のいずれか一つで示されるアミノ酸配
   列において、一部のアミノ酸が欠失、置換又は付加され
   たアミノ酸配列から成り、（ａ）のポリペプチドの機能
   と実質的に同質の生物学的活性を有するポリペプチド。
5. 【請求項５】 請求項３に記載の遺伝子にコードされる
   組換え蛋白質。