JP2002326920A - Emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an emulsion composition in an emulsified state including a part having an oil phase as an external phase such as a water-in-oil shape and a multiphase emulsified state having excellent touch feeling and stability. SOLUTION: This emulsion composition contains one or more kinds selected from a citric acid ester of glycerol stearate and a skin humectant component. A ceramide, a ceramide derivative, sphingosine, phytosterol, a phytosterol glycoside, a methacryloyloxyethoxyphosphorylcholine polymer, a copolymer of methacryloyloxyethoxyphosphorylcholine and a vinylic monomer or the like is preferably exemplified as the skin humectant component.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an emulsified composition, and more particularly to an emulsified composition useful for cosmetics and external medicine for skin.

[0002]

2. Description of the Prior Art Emulsified compositions can contain both lipophilic and hydrophilic components, which makes them useful dosage forms in areas requiring treatment of both oily and aqueous components. Has become. As such a field, for example, fields such as cosmetics, medicine, and food can be particularly preferably exemplified. Among such emulsifying agent forms, emulsifying forms having a portion having an oil phase in an external phase, such as a water-in-oil emulsifying form and a multi-phase emulsifying form, improve the percutaneous absorbability of the active ingredient or make the active ingredient compatible with the skin. Excellent,
It has been known that it has an effect of improving the skin barrier function and the like, and is particularly useful as a cosmetic or a pharmaceutical preparation for external use on skin.

In the emulsified form having a portion having an oil phase in the external phase, such as a water-in-oil emulsified form or a multi-phase emulsified form, the above-described favorable effects are seen, but the oily component forming the oil phase has a poor feel. Because it appears strongly at the time of use, from the meaning of such a feeling improvement, by increasing the amount of the aqueous phase forming the internal phase to the limit or by taking a multi-phase emulsified form,
Attempts have been made to increase the water content, but in such forms, the stability is often impaired and stable, high in water content, such as water-in-oil emulsified form or multi-phase emulsified form At present, an emulsified form having a portion having an oil phase in the external phase has not yet been obtained.

On the other hand, it contains glycerol stearic acid citrate and one or more skin moisturizing components such as ceramide, ceramide derivatives, sphingosine, phytosterol, phytosterol glycoside, and methacryloyloxyethoxyphosphorylcholine polymer. No emulsified composition having a portion having an oil phase in an external phase such as a water-in-oil emulsified form or a multi-phase emulsified form, which is characterized by the fact that no such emulsified composition is known, However, it was not known at all that it was an emulsion excellent in feel and stability.

[0005]

DISCLOSURE OF THE INVENTION The present invention has been made under such circumstances, and the oil phase such as a water-in-oil emulsified form and a multi-phase emulsified form which is excellent both in feel and stability. It is an object of the present invention to provide an emulsified composition having an emulsified form having a portion having in the external phase.

[0006]

In view of such a situation, the present inventors have developed a part having an oil phase, such as a water-in-oil emulsified form or a multi-phase emulsified form, which is excellent in feel and stability. As a result of diligent research efforts for an emulsified composition having an emulsified form having one or more selected from glycerol stearate citrate and a skin moisturizing component, emulsification is characterized by comprising: The finding of such properties in the composition led to the completion of the invention. That is, the present invention relates to the following technology. (1) An emulsion composition comprising one or more selected from glycerol stearic acid citrate and a skin moisturizing component. (2) The skin moisturizing component is one or more selected from ceramide, ceramide derivative, sphingosine, phytosterol, phytosterol glycoside, and methacryloyloxyethoxyphosphorylcholine polymer. An emulsified composition as described in the above. (3) The emulsified composition according to (1) or (2), which is an emulsified form including a form having an oil phase in an external phase. (4) The emulsion composition according to any one of (1) to (3), which is in a water-in-oil emulsion form or a multi-phase emulsion form. (5) (1) to (4) characterized by being a cosmetic.
An emulsified composition according to any one of the preceding claims. (6) An emulsion composition containing 1) glycerol stearic acid citrate and 2) one or more selected from ceramide, ceramide derivative, sphingosine, phytosterol, phytosterol glycoside, and methacryloyloxyethoxyphosphorylcholine polymer. . Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0007]

DESCRIPTION OF THE PREFERRED EMBODIMENTS (1) Glycerol stearic acid citrate as an essential component of the emulsion composition of the present invention The emulsion composition of the present invention contains glycerol stearic acid citrate as an essential component. Features. Glycerol stearic acid citrate is
Glycerin is a generic term for a complex ester in which at least one of the three hydroxyl groups is substituted with a stearoyloxy group and at least one is substituted with a carboxyl group of citric acid, and the compound is monostearoyloxyglyceryl monocitrate. , Distearoyloxyglyceryl monostearate, disitroyloxyglyceryl monostearate and the like, and are usually used in a mixture thereof. Since such a mixture is already commercially available, such a commercially available product can be used. These glycerol stearic acid citrates have the effect of improving the strength of the emulsified interface in the emulsified composition. The preferred content of the glycerol stearate citrate in the emulsified composition of the present invention is 0.1 to 10% by weight based on the total amount of the emulsified composition, and more preferably 0.5 to 5% by weight. % By weight. This is because if the amount of such components is too small, the effect of imparting strength to the interface may not be obtained, and if the amount is too large, the stability may be impaired.

(2) Essential components of the emulsified composition of the present invention The emulsion of the present invention is characterized in that it contains a skin moisturizing component in addition to the glycerol stearate citrate. The skin moisturizing component refers to a component that is present on the skin and enhances the skin barrier function, and has an effect of enhancing the moisturizing property of the skin.Specifically, ceramide, a ceramide derivative, sphingosine, phytosterol, phytosterol glycoside, Preferable examples include methacryloyloxyethoxyphosphorylcholine polymer (hereinafter, poly-MPC) and copolymers of methacryloyloxyethoxyphosphorylcholine with vinyl monomers (hereinafter, poly-MPC copolymer), and ceramide, ceramide derivative, sphingosine, phytosterol, phytosterol glycoside And methacryloyloxyethoxyphosphorylcholine polymer are particularly preferred. Ceramide has subtypes 1 to 6, and any of these can be used, but ceramide type 6 is particularly preferable due to its effects. Phytosterols are preferably exemplified by campesterol, sitosterol, stigmastanol and the like, and any of these can be used. As the glycoside, glycoside, mannoside, maltoside, rhamnoside, galactoside, xylobioside and the like can be preferably exemplified, and glucoside and maltoside are particularly preferable from the viewpoint of effect. These may contain only one kind or two or more kinds in combination. These are contained in the emulsified composition in combination with the glycerol stearic acid citrate, particularly in an emulsified form including a form having an oil phase in the external phase, the skin moisturizing component has a skin protection function of the emulsified form. Notably, the effect of improving the stability without deteriorating the advantage of good feel of the high-internal-phase water-in-oil emulsion composition or the multi-phase emulsion composition is exerted. The preferable content of the skin moisturizing component in the emulsified composition of the present invention is preferably 0.01 to 10% by weight, preferably 0.05 to 5% by weight, based on the total amount of the emulsified composition.
% By weight is more preferred. This is because if the amount is too small, the effect of further imparting a moisturizing effect may be impaired, and if the amount is too large, the stability and feel may be impaired.

(3) Emulsion composition of the present invention The emulsified composition of the present invention is characterized by containing glycerol stearate citrate, which is an essential component, and a skin moisturizing component. The emulsified form of the emulsified composition of the present invention is not particularly limited as long as it is known. This is because the constitution of the present invention is an oil-in-water emulsified form, a water-in-oil emulsified form, or a multi-phase emulsified form.
This is because the effect of improving the moisturizing effect is exhibited. However, an emulsified form including a form having an oil phase in the external phase, such as a water-in-oil emulsified form or a multi-phase emulsified form, in which such effects are most exhibited is particularly preferable.

[0010] The emulsion composition of the present invention may contain, in addition to the above essential components, optional components usually used in emulsion compositions. Such optional components include, for example, hydrocarbons such as squalane, petrolatum, microcrystalline wax, jojoba oil, carnauba wax,
Esters such as octyldodecyl oleate, triglycerides such as olive oil, tallow, coconut oil, fatty acids such as stearic acid, oleic acid and ritinoleic acid, higher alcohols such as oleyl alcohol, stearyl alcohol and octyldodecanol, sulfosuccinate esters and the like. Anionic surfactants such as polyoxyethylene alkyl sodium sulfate, amphoteric surfactants such as alkyl betaine salts, cationic surfactants such as dialkylammonium salts, sorbitan fatty acid esters, fatty acid monoglycerides, and polyoxyethylene adducts thereof , Polyoxyethylene alkyl ethers, nonionic surfactants such as polyoxyethylene fatty acid esters, isoprene glycol, 1,2-pentanediol, polyethylene glycol, glycerin, 3- polyhydric alcohols such as butanediol, thickening-gelling agents, antioxidants, ultraviolet absorbers, coloring materials, preservatives, powders and the like can be preferably exemplified. It can be produced by treating these essential components and optional components according to a conventional method.

As described above, the emulsified composition of the present invention comprises:
It has an effect of improving the stability as an emulsion, an effect of improving the feel when applied to the skin, and an effect of improving the moisturizing effect of the skin, and is therefore preferably used as a base for external use on the skin. As a base used for such skin external use,
Preferred examples include cosmetics and skin external medicines. In particular, it is particularly preferable to apply the emulsified composition of the present invention to cosmetics because of its gentleness on the skin. More preferably, it can be exemplified to be applied to cosmetics for sensitive skin because of its properties.

[0012]

The present invention will be described in more detail with reference to the following examples, but it goes without saying that the present invention is not limited to these examples.

<Example 1> An emulsified composition of the present invention was obtained according to the following formulation. That is, the components (a) and (b)
, And slowly add the ingredients of (b) to the ingredients of (a) with stirring.
After preparing the emulsified particles with a homogenizer, the mixture was stirred and cooled to obtain an oil-in-water emulsion of the present invention. Comparative Example 1 in which glycerol stearic acid citrate was replaced with glyceryl monostearate and ceramide (type 6)
Was replaced with water, and the feeling of use as a cosmetic was determined by five expert panelists. The evaluation items for the feeling of use were three items: good spreadability, close contact with the skin, and no stickiness. The evaluation criteria were ++: very good, +:
Good, ±: normal,-: somewhat bad,-: bad.
Table 1 shows the results. From this, the emulsified composition of the present invention,
It can be seen that the cosmetic has an extremely good feeling of use. I Squalane 10 parts by weight Jojoba oil 5 parts by weight Microcrystalline wax 2 parts by weight Bacyl alcohol 3 parts by weight Sorbitan sesquistearate 2 parts by weight Polyoxyethylene (100) stearyl ether 1 part by weight Polyoxyethylene (2) stearyl ether 0.5 Parts by weight butyl paraben 0.1 part by weight ceramide (type 6) 0.1 part by weight glycerol stearic acid citrate 3 parts by weight b 1,2-pentanediol 5 parts by weight isoprene glycol 3 parts by weight sucrose 1 part by weight mannan 0 0.5 parts by weight Xanthan gum 0.5 parts by weight Water 63.3 parts by weight

[0014]

[Table 1]

Example 2 A water-in-oil emulsion composition, which is an emulsion composition of the present invention, was prepared according to the following formulation. That is, the components (a) and (b) were heated to 80 ° C. and gradually added to (a). The mixture was added with stirring and cooled with stirring to obtain a water-in-oil emulsion composition, which is an emulsion composition of the present invention. This was prepared in the same manner as in Example 1 except that Comparative Example 3 in which glycerol stearic acid citrate was replaced with glyceryl monostearate and Comparative Example 4 in which ceramide (type 6) was replaced with water were prepared. The feeling of use as a cosmetic was compared by five panelists. Table 2 shows the results. This indicates that the emulsified composition of the present invention has a very good feeling of use as a cosmetic. As for the stability, Comparative Examples 3 and 4 were in the low temperature range (−5 ° C.) and the high temperature range (45 ° C.).
C), the emulsion compositions of the present invention were all stable in one week, whereas the emulsion compositions of the present invention were all stable and excellent in stability. A Squalane 40 parts by weight Jojoba oil 5 parts by weight Microcrystalline wax 2 parts by weight Bacyl alcohol 3 parts by weight Sorbitan sesquistearate 2 parts by weight Sucrose palmitate 1.5 parts by weight Glyceryl monostearate 1.5 parts by weight Butyl paraben 0 0.1 parts by weight Ceramide (type 6) 0.1 parts by weight Glycerol stearic acid citrate 3 parts by weight b 1,2-pentanediol 5 parts by weight isoprene glycol 3 parts by weight sucrose 1 part by weight Mannan 0.5 part by weight Xanthan gum 0.5 parts by weight water 26.7 parts by weight

[0016]

[Table 2]

<Examples 3 to 12> The effect of the water-in-oil emulsion composition of Example 1 on the skin moisturizing component was changed to examine the effect. As effects, the feeling of use and stability were taken up in the same manner as in Examples 1 and 2. The evaluation of feeling of use was carried out by using the emulsified composition of Example 2 as a control for comparison, and was very good as compared with Example 2 (score 5) and good as compared with Example 2 (score 4). (Comparative Example 3), slightly worse than Example 2 (Score 2), poorer than Example 2, but better than the conventional product (Comparative Example 2 or 3) (Score 1). The evaluation was made by five expert panelists based on the criteria of the same as the product or worse than the conventional product (score 0). The results are shown in Table 3 as average scores. This shows that the skin moisturizers, which are essential components of the emulsified composition of the present invention, all show the effect of use and stability. A Squalane 40 parts by weight Jojoba oil 5 parts by weight Microcrystalline wax 2 parts by weight Bacyl alcohol 3 parts by weight Sorbitan sesquistearate 2 parts by weight Sucrose palmitate 1.5 parts by weight Glyceryl monostearate 1.5 parts by weight Butyl paraben 0 0.1 part by weight Skin moisturizing ingredient * 0.1 part by weight Glycerol stearic acid citrate 3 parts by weight b 1,2-pentanediol 5 parts by weight isoprene glycol 3 parts by weight sucrose 1 part by weight Mannan 0.5 part by weight Xanthan gum 0 5.5 parts by weight Water 26.7 parts by weight * Details are shown in Table 3.

[0018]

[Table 3] ** STM: Stigmasteranol maltoside

Example 13 According to the following formulation,
An emulsified composition of the present invention was prepared. That is, (a) and (b) were each heated to 70 ° C., and (b) was gradually added to (a) to obtain an intermediate oil-in-water emulsion 1. Using this, C, D and E are each heated to 80 ° C., D is gradually added to C, and finally E is added and stirred and cooled to obtain an oil-in-water-in-oil emulsified composition of the present invention. A composition (Example 13) was obtained. This product had a smoother spreading property and was suitable as a cosmetic. The product was creamy even after returning to 20 ° C. after 3 days at −10 ° C. Even at 45 ° C for one week or at -5 ° C,
Weekly stable. Comparative Example 5 in which glycerol stearate citrate was replaced with water, poly MP
In Comparative Example 6 in which C was replaced with water, all were slightly separated at −5 ° C. for one week, confirming the stability of the emulsified composition of the present invention. A 10% aqueous potassium hydroxide solution 0.1 parts by weight 1,3-butanediol 3 parts by weight Xanthan gum 0.1 parts by weight Mannan 0.1 parts by weight Sucrose 0.3 parts by weight Water 15 parts by weight Robehenyl alcohol 0.4 parts by weight Part glycerol stearic acid citrate 0.5 part by weight glyceryl monostearate 0.1 part by weight squalane 4.5 parts by weight sucrose palmitate 2 parts by weight phenoxyethanol 0.2 parts by weight mixed fatty acid triglyceride *** 0.1 Parts by weight Behenic acid 0.1 parts by weight Stearic acid 0.5 parts by weight Glycerin 3 parts by weight C methylparaben 0.1 parts by weight 1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Polyethylene glycol 1500 1 part by weight Poly MPC 0. 1 part by weight water 26.88 parts by weight -135 "1 part by weight" Eldew PS-304 "0.1 part by weight Macadamia fatty acid phytosteryl 0.5 part by weight Camellia oil 0.5 part by weight Decamethylcyclopentasiloxane 4 parts by weight Cetyl 2-ethylhexanoate 19 parts by weight" Cropure " OL "1 part by weight Sorbite isostearate 1 part by weight Butyl paraben 0.1 part by weight δ Tocopherol 0.02 part by weight E Intermediate oil-in-water emulsion 1 30 parts by weight Touki extract 1 part by weight Chorei extract 0.7 part by weight Tonin extract 0 0.8 parts by weight Chimpi extract 0.5 parts by weight *** Tri (capric acid / caprylic acid / myristic acid / stearic acid) glyceride

<Example 14> According to the following formulation,
An emulsified composition of the present invention was prepared. That is, (a) and (b) were each heated to 70 ° C., and (b) was gradually added to (a) to obtain an intermediate oil-in-water emulsion 2. Using this, C, D and E are each heated to 80 ° C., D is gradually added to C, and finally E is added and stirred and cooled to obtain an oil-in-water-in-oil emulsified composition of the present invention. A composition (Example 14; pharmaceutical composition) was obtained. This product had a smoother spreading property and was suitable as a cosmetic. This is 20 ° C 3 days after -10 ° C
It was creamy on return. Even at 45 ° C for one week,
It was stable for one week even at -5 ° C. Comparative Example 7 in which glycerol stearic acid citrate was replaced with water and Comparative Example 8 in which poly MPC was replaced with water were all -5.
C., slightly separated after 3 days, confirming the stability of the emulsified composition of the present invention. A 10% aqueous solution of potassium hydroxide 0.1 part by weight 1,3-butanediol 3 parts by weight Xanthan gum 0.1 part by weight Mannan 0.1 part by weight Sucrose 0.3 part by weight Water 14 parts by weight Robehenyl alcohol 0.4 part by weight Part glycerol stearic acid citrate 0.5 part by weight glyceryl monostearate 0.1 part by weight squalane 4.5 parts by weight sucrose palmitate 2 parts by weight phenoxyethanol 0.2 parts by weight mixed fatty acid triglyceride *** 0.1 Parts by weight Behenic acid 0.1 part by weight Stearic acid 0.5 part by weight Glycerin 3 parts by weight Vitamin A acid 1 part by weight C methyl paraben 0.1 part by weight 1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Polyethylene glycol 1500 1 Parts by weight Poly MPC 0.1 parts by weight Water 26.8 Parts by weight D "Aracer P-135" 1 part by weight "Eldew PS-304" 0.1 part by weight Macadamia fatty acid phytosteryl 0.5 part by weight Camellia oil 0.5 part by weight Decamethylcyclopentasiloxane 4 parts by weight 2-ethylhexanoic acid Cetyl 19 parts by weight "CroPure OL" 1 part by weight Sorvite isostearate 1 part by weight Butyl paraben 0.1 part by weight δ Tocopherol 0.02 parts by weight E Intermediate oil-in-water emulsion 230 30 parts by weight 0.7 parts by weight Tonin extract 0.8 parts by weight Chimney extract 0.5 parts by weight

Example 15 According to the following formulation,
An emulsified composition of the present invention was prepared. That is, (a) and (b) were each heated to 70 ° C., and (b) was gradually added to (a) to obtain an intermediate oil-in-water emulsion 3. Using this, C, D and E are each heated to 80 ° C., D is gradually added to C, and finally E is added and stirred and cooled to obtain an oil-in-water-in-oil emulsified composition of the present invention. A composition (Example 15; pharmaceutical composition) was obtained. This product had a smoother spreading property and was suitable as a cosmetic. This is 20 ° C 3 days after -10 ° C
It was creamy on return. Even at 45 ° C for one week,
It was stable for one week even at -5 ° C. Comparative Example 9 in which glycerol stearic acid citrate was replaced with water and Comparative Example 10 in which poly MPC was replaced with water were all −
The emulsion was slightly separated at 5 ° C for one week, confirming the stability of the emulsified composition of the present invention. A 10% aqueous potassium hydroxide solution 0.1 parts by weight 1,3-butanediol 3 parts by weight Xanthan gum 0.1 parts by weight Mannan 0.1 parts by weight Sucrose 0.3 parts by weight Water 15 parts by weight Robehenyl alcohol 0.4 parts by weight Part glycerol stearic acid citrate 0.5 part by weight glyceryl monostearate 0.1 part by weight squalane 4.5 parts by weight sucrose palmitate 2 parts by weight phenoxyethanol 0.2 parts by weight mixed fatty acid triglyceride *** 0.1 Parts by weight behenic acid 0.1 parts by weight stearic acid 0.5 parts by weight glycerin 3 parts by weight fluconazole 1 part by weight c methyl paraben 0.1 parts by weight 1,3-butanediol 5 parts by weight glycerin 5 parts by weight polyethylene glycol 1500 1 part by weight 25. Poly MPC 0.1 part by weight water 8 parts by weight D "Aracel P-135" 1 part by weight "Eldew PS-304" 0.1 part by weight Macadamia fatty acid phytosteryl 0.5 part by weight Camellia oil 0.5 part by weight Decamethylcyclopentasiloxane 4 parts by weight 2-ethylhexane Cetyl acid 19 parts by weight Cropure OL 1 part by weight Sorvitol isostearate 1 part by weight Butyl paraben 0.1 part by weight δ Tocopherol 0.02 parts by weight E Oil-in-water emulsion 3 30 parts by weight Touki extract 1 part by weight Chorei extract 0.7 parts by weight Tonin extract 0.8 parts by weight Chimney extract 0.5 parts by weight

[0022]

According to the present invention, an emulsified composition having a portion having an oil phase in an external phase, such as a water-in-oil emulsified form and a multi-phase emulsified form, which is excellent both in terms of feel and stability, is provided. Can be provided.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 9/107 A61K 9/107 31/133 31/133 31/164 31/164 31/575 31/575 31 / 704 31/704 31/80 31/80 47/14 47/14 A61P 17/16 A61P 17/16 F term (reference) 4C076 AA18 BB31 CC18 DD08 DD34 DD38 DD39 DD45 DD46 DD52 DD67 DD68 EE23 EE30 EE53 FF16 FF43 FF57 GG45 4C083 AA112 AA122 AB032 AB052 AC012 AC022 AC072 AC112 AC122 AC182 AC242 AC352 AC421 AC422 AC442 AC472 AC482 AC541 AC641 AC642 AC852 AD042 AD172 AD202 AD212 AD222 AD491 AD492 AD572 AD622 AD662 BB04 BB13 BB35 BB51 CC05 DD32 EE01 MA05 MA05 NA03 NA14 ZA89 ZC80 4C206 FA03 GA03 GA26 MA02 MA03 MA05 MA21 MA28 MA29 MA30 MA42 MA83 NA03 NA14 ZA89 ZC80

Claims (6)

[Claims] 1. An emulsified composition comprising one or more selected from glycerol stearic acid citrate and a skin moisturizing component. 2. The skin moisturizing component is one or two or more selected from ceramide, ceramide derivatives, sphingosine, phytosterol, phytosterol glycoside, and methacryloyloxyethoxyphosphorylcholine polymer. 2. The emulsion composition according to 1. 3. The emulsified composition according to claim 1, which is in an emulsified form including a form having an oil phase in an external phase. 4. The emulsified composition according to claim 1, wherein the emulsified composition is a water-in-oil emulsified form or a multi-phase emulsified form. 5. The emulsion composition according to claim 1, which is a cosmetic. 6. An emulsion containing 1) glycerol stearic acid citrate and 2) one or more selected from ceramide, ceramide derivative, sphingosine, phytosterol, phytosterol glycoside and methacryloyloxyethoxyphosphorylcholine polymer. Composition.