JP2002293987A - Water gel composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a water gel composition easily produced owing to a proper gelation velocity, excellent in shape stability and gel strengths, homogeneous and having little separated water and beautiful in its appearance. SOLUTION: This water gel composition consists of (a) water, (b) a CMC and/or a CMC-Na prepared by blending one or more CMCs and/or CMCs-Na having 0.4-0.9 degree of etherification and 10-5000 mPa.s viscosity in 1% aqueous solution at 25 deg.C and one or more CMCs and/or CMCs-Na having 1.0-2.0 degree of etherification and 100-10000 mPa.s viscosity in 1% aqueous solution at 25 deg.C in a weight ratio of 79:21-50:50, (c) an aluminum hydroxide gel and (d) an organic acid.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an aqueous gel composition. More specifically, it is composed of an aqueous gel formed from carboxymethylcellulose (hereinafter, referred to as “CMC”) and / or its sodium salt (hereinafter, referred to as “CMC-Na”) and an aluminum hydroxide gel, and has an appropriate gelation rate. The present invention relates to an aqueous gel composition which can be easily produced, has excellent shape stability and gel strength, is uniform, has a small amount of water separation, and has a beautiful appearance.

[0002]

2. Description of the Related Art To meet the needs for a more comfortable living space as lifestyles change, toiletries such as various fragrances, deodorants, deodorants, fungicides, fungicides, and repellents have been developed. It has been commercialized. Above all, a solid type using a gelling agent has the advantages of excellent release and sustainability of the contained drug and easy handling. As gel-like toiletry products, an aqueous gel type using water as a solvent and an oily gel type using a terpene-based hydrocarbon as a solvent are known. Things occupy the mainstream.

[0003] Conventionally, as a toiletry product using an aqueous gel, those using various gelling agents are known. For example, what is manufactured by heating and dissolving a gelling agent, such as carrageenan or agar, which is a natural polysaccharide, in water, adding a flavoring agent and a deodorant in an emulsified state, and then cooling it to gel. (JP-B-55-1812, JP-A-50-70532, JP-A-56-57451). However, since carrageenan and agar are raw materials derived from natural products, their prices are unstable, and as a production method, they are heated and dissolved at 60-80 ° C. in the presence of perfume, which means that volatilization and deterioration of perfume There is a problem that liquefaction and water separation tend to occur in an environment of 50 ° C. or higher. Since a cooling operation is required after heating and melting, there are disadvantages such as high energy consumption in the production method.

Further, Japanese Patent Publication No. 5-28259 and Japanese Patent Application Laid-Open No. H11-106561 disclose a method of using microfibril cellulose in combination with CMC as a base for an aqueous gel in order to enhance stability. As a method for producing a gel having a small amount of water, a method of crosslinking CMC with basic aluminum acetate is disclosed. But,
There is a problem that a gel having a gel strength that is satisfactory as a fragrance cannot be obtained, shape stability is poor, and a large amount of water is separated. In addition, when basic aluminum acetate is used as a cross-linking agent, there is a problem in that it cannot be used as an aromatic because of acetic acid odor, and there is a problem in production because the gelation rate is too high. An aqueous gel is obtained by a cross-linking reaction between CMC and / or CMC-Na and a polyvalent metal ion,
For example, promoting an ionic reaction of an inorganic salt containing a polyvalent metal ion such as aluminum with CMC and / or CMC-Na in an aqueous solution to form a three-dimensional network-like cross-linked structure by ionic bonding to form an aqueous gel. Is already known.

In this method, the gelation rate and the gel physical properties (strength, water separation) depend on the solubility of the polyvalent metal salt. For example, the gelation rate of a polyvalent metal salt having high water solubility is extremely high. Crosslinking is also uneven and water cannot be retained in the gel, resulting in increased water separation. On the other hand, in the case of a polyvalent metal salt having low solubility in water, the elution of polyvalent metal ions contributing to cross-linking is small, the gelation rate is extremely slow, and the strength of the generated gel is also poor. That is, in an aqueous gel composition using conventional CMC and / or CMC-Na,
It was not possible to obtain a gel composition having an appropriate gelation rate in the production process, excellent gel strength as a function required as an aqueous gel composition, and a small amount of water separation.

[0006]

The present invention has been made in view of the above circumstances, and has excellent shape stability and gel strength, is uniform, has a small amount of water separation, has a beautiful appearance, and has an appropriate gelation rate. It is an object of the present invention to provide an aqueous gel composition which can be produced efficiently with a gel.

[0007]

Means for Solving the Problems Focusing on such a conventional problem, as a result of diligent research, it has been found that C with low etherification degree
CMC mixed with MC and / or CMC-Na and high etherification degree CMC and / or CMC-Na
The present invention was found to be effective in solving the above-mentioned problems by forming an aluminum hydroxide gel and further an organic acid in addition to CMC-Na and / or CMC-Na, and completed the present invention.

That is, the present invention relates to (a) water, (b) one or more carboxymethyl celluloses having a degree of etherification of 0.4 to 0.9 and a 1% aqueous solution viscosity at 25 ° C. of 10 to 5000 mPa · s. And / or one or more carboxymethylcellulose having a degree of etherification of 1.0 to 2.0 and a 1% aqueous solution viscosity at 25 ° C of 100 to 10,000 mPa · s and / or a sodium salt thereof, and / or a sodium salt thereof. Carboxymethylcellulose and / or its sodium salt mixed at 79:21 to 50:50, (c) aluminum hydroxide gel, and (d)
An aqueous gel composition comprising an organic acid (claim 1); and (e) one or more drugs selected from the group consisting of fragrances, deodorants, deodorants, fungicides, fungicides, and repellents. The aqueous gel composition according to claim 1 (claim 2), an organic acid (d).
Is an at least one selected from aliphatic oxymonocarboxylic acids and aliphatic dicarboxylic acids, the aqueous gel composition according to claim 1 or 2, wherein the pH of the composition is 3.0.
The aqueous gel composition according to claim 1, 2 or 3, wherein the content of carboxymethylcellulose and / or its sodium salt is 1.5 to 6.0.
5.0% by weight, and the mixing ratio of the aluminum hydroxide gel is such that carboxymethyl cellulose and / or its sodium salt and A contained in the aluminum hydroxide gel
The aqueous gel composition according to claim 1, 2, 3 or 4, wherein the weight ratio in terms of l ₂ O ₃ is 95: 5 to 70:30.

[0009]

DETAILED DESCRIPTION OF THE INVENTION CMC and / or CMC-Na (b) used in the present invention have a specific degree of etherification of 1%
It is necessary to mix and use CMC and / or CMC-Na selected from two groups having an aqueous solution viscosity at a specific ratio. CMC-Na is a water-soluble polymer in which the hydroxyl groups of cellulose are etherified with sodium monochloroacetate, and is specified by a matrix of the degree of etherification, which is a numerical value indicating the degree of substitution of the hydrophilic group, and the viscosity of the aqueous solution governed by the degree of polymerization. Various products are manufactured and sold depending on the application.

[0010] CMC and / or CM used in the present invention
C-Na (b) has a degree of etherification of 0.4 to 0.9,
One or more low-etherification CMC and / or C having a 1% aqueous solution viscosity of 5 ° C. of 10 to 5000 mPa · s.
MC-Na, etherification degree 1.0-2.0, 25 ° C
At least one kind of CMC and / or CMC having a high etherification degree of 1% aqueous solution viscosity of 100 to 10000 mPa · s
MC-Na was added in a weight ratio of 79:21 to 50:50 based on anhydride.
Only CMC mixed at 50 is valid. The degree of etherification is 0.4 to 0.9, and the viscosity of a 1% aqueous solution at 25 ° C is 10 to 5
If prepared using only CMC of 000 mPa · s, sufficient gel strength cannot be obtained, shape stability is poor, and the gel composition is not suitable as an aqueous gel composition. However, the low etherification degree of CMC is 79 to 50% by weight, and the higher degree of substitution has a higher etherification degree of 1.0 to 2.0, and a 1% aqueous solution at 25 ° C has a viscosity of 100 to 10,000 mPa · s. 21 to 50% by weight of CMC, preferably 24 to 4%.
When used in a proportion of 0% by weight, the crosslink density with aluminum is uniformly and appropriately increased, so that the gel strength is remarkably increased and an aqueous gel with a small amount of water separation can be obtained.

CMC and / or C with a low degree of etherification
Although the degree of etherification of MC-Na is 0.4 to 0.9,
It is preferably 0.5 to 0.9, and the viscosity of a 1% aqueous solution at 25 ° C. is 10 to 5000 mPa · s.
It is preferably 4000 mPa · s. On the other hand, the degree of etherification of CMC and / or CMC-Na having a high degree of etherification is 1.0 to 2.0, but is preferably 1.2 to 1.8, and the viscosity of a 1% aqueous solution is 10 to 10%. 1000
The pressure is 0 mPa · s, but preferably 50 to 8000 mPa · s.

Low etherification CMC and / or CMC
If the degree of etherification of MC-Na is lower than 0.4, water solubility is insufficient and a uniform gel cannot be obtained,
When the water content exceeds the range, the amount of water separation tends to increase. In addition, the degree of etherification of CMC and / or CMC-Na having a high degree of etherification needs to be 1.0 to 2.0, and if other than that, the amount of water separation is small and the gel strength is excellent. Can not be obtained. On the other hand, if the value exceeds 2.0, the price becomes expensive, which is economically disadvantageous.

Further, CMC having a low degree of etherification and / or
Alternatively, as the viscosity of the aqueous solution of CMC-Na,
% Aqueous solution viscosity (anhydrous equivalent concentration, 25 ° C., measured with a B-type viscometer (rotational speed 60 rpm)) is 10 to 5000 mPa.
S is required, but 50 to 4000 mPa
S is preferred. When the viscosity is lower than 10 mPa · s, the gel strength becomes weak, and when the viscosity exceeds 5000 mPa · s, the viscosity before gelation is too high to be able to be poured into a container. CMC and / or CM used from this
If the C-Na concentration is low, an aqueous gel composition having high gel strength cannot be obtained.

On the other hand, CM having a higher degree of etherification
Similarly, the viscosity of the aqueous solution of C and / or CMC-Na is 1% aqueous solution viscosity at 25 ° C (anhydrous concentration, 25 ° C, B
100 to 10 (measured by viscometer (rotation speed: 60 rpm))
000 mPa · s, but 200 to
It is preferably 8000 mPa · s. CMC and / or CMC-Na with a high degree of etherification require an aqueous solution viscosity of 100 to 10000 mPa · s,
If a material other than the above is used, a material having a small amount of water separation and excellent in gel strength cannot be obtained.

[0015] Both the low etherification degree CMC and / or CMC-Na and the high etherification degree CMC and / or CMC-Na are both within the range specified by the degree of etherification and the 1% aqueous solution viscosity matrix. Can be used in a mixture of two or more. The mixing ratio is 79:21 to 50:50, preferably 76:24 to 60:40 by weight based on anhydride. When the mixing ratio of CMC and / or CMC-Na with a low degree of etherification exceeds 79% by weight, the gel strength is poor, and when the mixing ratio of CMC and / or CMC-Na with a high degree of etherification exceeds 50% by weight. Although it is possible to increase the gel strength, it is difficult to obtain a gel with less water separation.

The content of CMC and / or CMC-Na (b) in the aqueous gel composition is 1.
It is preferably 5 to 5.0% by weight, and 2.0 to 4.0% by weight.
More preferably, it is 0% by weight. If it is lower than 1.5% by weight, sufficient gel strength cannot be obtained, while if it exceeds 5.0% by weight, the viscosity before gelation tends to be extremely high, and it tends to be difficult to inject into a container.

The aluminum hydroxide gel (c) used in the present invention functions as a crosslinking agent that forms an aqueous gel by crosslinking with CMC and / or CMC-Na. The aluminum hydroxide gel is produced, for example, by adding ammonium carbonate or sodium carbonate to an aluminum salt solution, or by passing carbon dioxide gas through a sodium aluminate solution to cause precipitation. A commercially available product is also available as a dried aluminum hydroxide gel produced by washing the precipitate and drying it under appropriate conditions. Hydrar for aluminum hydroxide
The gillite type, Bayerite type, Bohmite type and amorphous type are known, but only the amorphous type aluminum hydroxide gel is effective. The dry aluminum hydroxide gel may have different bulk specific gravity and particle size depending on the production method, but is not particularly limited in use.

When a dry aluminum hydroxide gel is used, the content of Al ₂ O _{3 in} the gel is not particularly limited, but those having a weight of 45 to 70% by weight are commercially available commercially.

In the aqueous gel composition of the present invention, CMC
And / or degree of etherification of CMC-Na (degree of substitution)
Of Aluminum Ions in Aluminum and Aluminum Hydroxide Gel
The mixing ratio affects the degree of cross-linking and the uniformity of cross-linking.
Alcohol used to affect the gel properties of the product
The amount of the minium gel is an important factor. That is,
CMC and / or CMC-Na and aluminum hydroxide
The mixing ratio with mugel is CMC and / or CMC-N
a and Al contained in aluminum hydroxide gel _TwoO_ThreeConversion
95: 5 to 70:30 by weight.
Is preferable, and the ratio is more preferably from 92: 8 to 80:20.
preferable. CMC and / or CMC-Na 95
If it exceeds, the cross-linking becomes insufficient and the gel strength becomes inferior.
On the other hand, if it is less than 70, a strong gel is obtained,
It is not preferable because it becomes easy.

Furthermore, the present inventors have found that it is effective to use a specific organic acid (d) in order to gradually elute aluminum from the aluminum hydroxide gel and to promote uniform and smooth crosslinking. .

The organic acid (d) used in the present invention includes at least one selected from aliphatic oxymonocarboxylic acids and aliphatic dicarboxylic acids. In particular,
Examples of the aliphatic oxymonocarboxylic acid include glycolic acid, lactic acid, oxybutyric acid, glyceric acid, and gluconic acid. Examples of the aliphatic dicarboxylic acid include oxalic acid, malonic acid, succinic acid, glutaric acid, maleic acid, and fumaric acid. These organic acids may be used alone or in combination of two or more.

By adjusting the pH of the system by blending the organic acid, aluminum ions are eluted from the aluminum hydroxide gel, and CMC and / or CMC-Na
Can be crosslinked. The pH range of the system is from 3.0 to
It is preferably adjusted to 6.0, more preferably 3.5 to 5.5. When the pH is lower, the reaction is faster, but when the pH is less than 3.0, the gel strength is inferior. When the pH is more than 6.0, the reaction is very slow, and further the crosslinking is insufficient. It tends not to be obtained.
Although the amount of the organic acid varies depending on the type of the acid, it is usually preferably from 0.3 to 2.0% by weight, and more preferably from 0.5 to 1.5% by weight, based on the entire aqueous gel composition. Is more preferable. When the amount is less than 0.3% by weight, the elution of aluminum ions by the organic acid is small, and the gel strength is insufficient. When the amount exceeds 2.0% by weight, the aqueous gel composition tends to have a large amount of water separation.

The aqueous gel composition of the present invention further comprises a fragrance,
It can contain one or more drugs (e) selected from the group consisting of deodorants, deodorants, fungicides, bactericides, and repellents.

The fragrance is not particularly limited, and any conventionally used fragrance can be used. In addition to various flavors, there are essential oils and the like. For example, for natural flavors, grapefruit oil, Costas oil, citronella oil, jasmine oil, sweet orange oil, spearmint oil, pine oil, patchouli oil, sea shell oil, bitter orange oil, hiba oil, peppermint oil, bergamot oil, mandarin oil , Eucalyptus oil, lavender oil, lemon oil, lemongrass oil, rose oil, rosemary oil, peppermint white oil, plant extractants as deodorants, etc., and α-pinene, β-pinene, limonene as synthetic flavors. Such as terpene hydrocarbons, linalool,
Terpene alcohols such as geraniol and nerol,
Benzyl alcohol, phenethyl alcohol, other alcohols such as γ-phenylpropyl alcohol, phenol derivatives such as diphenyl ether, isosafluoroeugenol, p-methylanisole, heptanal,
Aliphatic aldehydes such as octanal and nonanal, terpene aldehydes such as citral, citronellal, and hydroxycitronellal, aromatic aldehydes such as benzaldehyde, phenylacetaldehyde, and 3-phenylpropionaldehyde, and acetals such as citral dimethyl acetal and citral diethyl acetal. Aliphatic ketones such as, 2-heptanone, 3-octanone and 2-octanone; terpene-based ketones such as carvone, menthone and pulegone; p-methylacetophenone;
Aromatic ketones such as benzophenone and benzylideneacetone; alicyclic ketones such as α-, β-, γ-ionone, theaspirane and jasmine lactone; macrocyclic ketones such as ether, lactone, muscone and ambrettolide;
Synthetic musk such as lactone, musk xylene, musk ketone, musk ambrette, rose oxide, 1,8
-Cineol, cyclic ethers such as bicyclodihydrohomofarnesyl oxide, heterocyclic compounds such as indole, 6-methylquinoline and 2-furylmethanethiol; esters of aliphatic acids such as benzyl formate, ethyl acetate and ethyl propionate; Esters of aromatic acids such as methyl acrylate, ethyl benzoate, ethyl phenylacetate, ethyl cinnamate, and isobutyl salicylate, and so-called aldehydes such as γ-heptylbutyrolactone and allyl hexanoate are used alone or in a suitable mixture.

Examples of the deodorant and deodorant include plant extract, amphoteric surfactants such as alkyldimethylaminoacetate betaine, alkylglycine salts, N-acylaminoethyl-N-2-hydroxyethylglycine salts, glyoxal, and methacrylic acid. Acid esters, unsaturated ester compounds such as maleic acid esters, etc., as fungicides, fungicides, as volatile, for example, thymol, stabilized chlorine dioxide, allyl isothiosionate, etc., as repellents, Examples include natural flavors, plant extracts, and wood vinegar.

The content of these drug components is preferably 0.1 to 15% by weight of the aqueous gel composition, and 1.0 to 1% by weight.
More preferably, it is 0.0% by weight. 0.1% by weight
If less than 15% by weight, sufficient drug effect cannot be obtained.
If the ratio exceeds the above range, the gel strength tends to be weak.

Water (a) is used as a medium of the composition. The amount of water is determined by the amount of the CMC gel base constituting the aqueous gel composition and the components such as a solvent, a surfactant, and various compounding agents described below. And usually 60-95% by weight
Becomes

In addition to water (a) as a medium, if necessary, ethanol, isopropyl alcohol, ethylene glycol, propylene glycol, 1,3-butanediol, hexylene glycol, etc.
Alcohols such as glycerin and glycols are blended.

Further, if necessary, surfactants such as anionic surfactants, amphoteric surfactants and nonionic surfactants are used as emulsifying and solubilizing agents for the drug components. Specifically, examples of the anionic surfactant include an alkylbenzene sulfonate, an alkyl sulfate, an alkyl ether sulfate, and an α-olefin sulfonate. Examples of amphoteric surfactants include alkyl betaines and fatty acid amide propyl betaines, and nonionic surfactants include higher alcohol ethylene oxide adducts, alkylphenol ethylene oxide adducts, fatty acid ethylene oxide adducts, and polyhydric alcohol fatty acid ester ethylenes. Oxide adducts, higher alkylamine ethylene oxide adducts, fatty acid alkanolamide ethylene oxide adducts, oil and fat ethylene oxide adducts, block copolymers of ethylene oxide and propylene oxide, glycerol fatty acid esters, pentaerythritol fatty acid esters, sorbitol And sorbitan fatty acid esters, sucrose fatty acid esters, polyhydric alcohol alkyl ethers, and alkanolamines fatty acid esters. Such as soil and the like.
Of these, alkyl sulfate salts, alkyl betaines, and higher alcohol ethylene oxide adducts are preferred from the viewpoint of emulsification and solubilizing power.

When a surfactant is used, its amount is preferably from 0.2 to 10% by weight, more preferably from 0.5 to 8.0% by weight, based on the whole aqueous gel composition. More preferred.

Further, a coloring agent, an antioxidant, an ultraviolet absorber, and a chelating agent are added to the aqueous gel composition of the present invention, if necessary.

The method for producing the aqueous gel composition of the present invention is not particularly limited. For example, CMC and / or CMC-Na and aluminum hydroxide gel are added to water, and the mixture is mixed and stirred to form a hydroxide. A CMC and / or CMC-Na aqueous solution in which an aluminum gel is dispersed is prepared. Next, a drug and an organic acid are added, mixed and stirred to prepare. The aqueous gel composition can be obtained by injecting the composition thus prepared into a molding container and allowing it to stand. A special advantage of the present invention is that a continuous production method by continuously supplying raw materials can be easily adopted.However, in the case of the present invention, the gelation reaction proceeds by adding an organic acid. Therefore, the steps up to the addition of the organic acid can be prepared in a batch system. The temperature in the production process may be room temperature or, if necessary, the system may be controlled at 5 ° C. to 60 ° C. to control the progress of gelation.
Is adjusted to the range. It is to be noted that a temperature of 60 ° C. or higher is not preferable because a loss of the chemical due to the volatilization of the low-volatile organic matter occurs.

The aqueous gel composition thus obtained can be used, for example, by filling it in the container shown in FIG. The container is composed of an upper lid 3 composed of a lower lid 2, a main body part 5 and a top lid part 6, a cylindrical part 4, and a columnar part 7, and can be filled with the aqueous gel composition of the present invention as a gel layer 1. it can.

[0034]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited to these examples unless it exceeds the gist. The percentages in the examples are on a weight basis.

Examples 1 to 18 and Comparative Examples 1 to 5 (Preparation of Aqueous Gel Composition) Table 1 shows the types of CMC used in the examples and comparative examples.

Aqueous gel compositions were prepared according to the formulations shown in Tables 2 to 5 by the following method. Here, P = 20 and P = 30 in the column of polyoxyethylene lauryl ether shown in Tables 2 to 5 indicate that the average addition mole number of ethylene oxide is 20 and 30, respectively.

CMC-Na and aluminum hydroxide gel were added to water and mixed by stirring to obtain an aluminum hydroxide gel dispersed CMC-Na aqueous solution. A mixed solution of a fragrance and an emulsifier or a deodorant was added with a homomixer while stirring at 4000 rpm, and the mixture was stirred for 2 minutes. Further organic acids,
After adding the preservative Caisson CG / ICP (manufactured by Rohm and Haas), the mixture was stirred for 3 minutes. Sample 14
0 g was filled in the container shown in FIG. 1 and left standing in a thermostat at 25 ° C. to obtain various physical property evaluation samples. In Comparative Example 3, a basic aluminum acetate tetrahydrate was used instead of the aluminum hydroxide gel in the above preparation method, and in Comparative Example 5, citric acid was used as the organic acid.

After filling the container, the inside of the container was observed every 30 minutes to measure the time until the fluidity disappeared, and this time was defined as the gelation time. The samples were prepared by the following methods: (1) syneresis, (2) gel strength, (3) gel uniformity, (4) p
H, (5) Container openability, (6) Volatility test was performed, and physical properties were evaluated.

(1) Amount of Water Separation After the prepared aqueous gel composition in a container was sealed and allowed to stand in a thermostat at 25 ° C. for 7 days, the upper lid 3 was removed, and the water in the gel contact portion, the gel surface and the container bottom was removed by filter paper. And the weight was measured and evaluated according to the following criteria. ：: Water separation amount less than 200 mg ○: 200 mg or more and less than 500 mg △: 500 mg or more and less than 1000 mg ×: 1000 mg or more

(2) Gel strength The sample after measuring the water separation amount of (1) is taken out of the container and
The gel strength was measured using a rheometer manufactured by Sun Kagaku and evaluated according to the following criteria. ◎: 350 g / cm ² or more ○: less than 350 g / cm ² 250 g / cm ² or more △: less than 250 g / cm ² 150 g / cm ² or more ×: less than 150 g / cm ²

(3) Container Opening / Closing Property After the prepared aqueous gel composition in a container was sealed and allowed to stand in a thermostat at 25 ° C. for 7 days, the upper lid 3 of FIG. 1 was opened and closed, and evaluated according to the following criteria. ：: A product that can be opened and closed easily Δ: A product that can be opened and closed ×: A product that cannot be opened and closed

(4) Gel Uniformity The appearance and cut surface of the aqueous gel composition taken out of the container were visually observed to determine the uniformity of the gel, and evaluated according to the following criteria. ：: Smooth and beautiful appearance and cut surface △: Slightly uneven appearance or cut surface (with irregularities) ×: Uneven appearance or cut surface

(5) pH The pH was measured by inserting a pH test paper into the gel.

(6) Volatilization test The upper lid 3 and the lower lid 3 in FIG. 1 are opened by 20 mm so that the fragrance and water of the aqueous gel composition can be volatilized, and the chamber is placed in a room at 20 ± 3 ° C., and after 2 months, the volatilization is performed. The state of the residue after completion was visually evaluated. ：: There is little residue, and there is no problem because the state is not unsightly at all. Δ: There is not much residue, and the state is not unsightly. ×: Many residues, unsightly.

Tables 6 to 8 show the gelation time and the results of evaluation of physical properties.

[0046]

[Table 1]

[0047]

[Table 2]

[0048]

[Table 3]

[0049]

[Table 4]

[0050]

[Table 5]

[0051]

[Table 6]

[0052]

[Table 7]

[0053]

[Table 8]

[0054]

The aqueous gel composition of the present invention is prepared by blending CMC and / or CMC-Na having a specific degree of etherification and an aqueous solution viscosity range, and using a specific crosslinking agent to control the rate of crosslinking to achieve uniformity. Because an aqueous gel can be prepared,
It is excellent in shape stability, gel strength and heat stability, and has a small amount of syneresis and beautiful appearance. Further, since a network structure having an appropriate water retention property is formed by uniformly cross-linking highly hydrophilic CMC and / or CMC-Na, volatilization of water and a drug is appropriately suppressed, and a wide variety of types can be obtained. Shows stable drug volatility with respect to drug components.

Therefore, the aqueous gel composition of the present invention
It can be effectively used as a gel composition for volatilizing a drug in the entrance, living room, indoors such as a toilet, a bathroom, a car, and the like.

[Brief description of the drawings]

FIG. 1 is a container of the aqueous gel composition used in Examples.

[Explanation of symbols]

 Reference Signs List 1 gel layer 2 lower lid 3 upper lid 4 tubular part 5 main body part 6 top lid part 7 columnar part

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) C09K 3/00 103 C09K 3/00 103J (72) Inventor Toshiro Hashizume 1-30-3 Toyokawa, Ibaraki-shi, Osaka Within Kobayashi Pharmaceutical Co., Ltd. (72) Fukushin Mayuzumi 55, Nishi-Shichijo Higashikubocho, Shimogyo-ku, Kyoto, Kyoto Prefecture Within Daiichi Kogyo Pharmaceutical Co., Ltd. Dai-ichi Kogyo Pharmaceutical Co., Ltd. F-term (reference) 4C080 AA04 AA05 BB02 BB04 CC01 HH06 JJ03 JJ09 KK03 KK08 LL05 LL06 MM01 MM03 MM14 MM31 NN24 QQ03 QQ16 QQ18 4J002 AB031 AB032 DE026 DE147 EF038 FD068 EF068 FD068

Claims (5)

[Claims] (A) water, (b) a degree of etherification of 0.4
0.9%, viscosity of 1% aqueous solution at 25 ° C is 10-5000m
At least one carboxymethylcellulose having a Pa · s and / or sodium salt thereof, a degree of etherification of 1.0 to 2.0, and a 1% aqueous solution at 25 ° C having a viscosity of 100 to 1
Carboxymethylcellulose and / or its sodium salt obtained by mixing at least one carboxymethylcellulose of 0000 mPa · s and / or its sodium salt in a weight ratio of 79:21 to 50:50, (c) aluminum hydroxide gel, and ( d) An aqueous gel composition comprising an organic acid. (E) a fragrance, a deodorant, a deodorant, a fungicide,
The aqueous gel composition according to claim 1, comprising one or more drugs selected from the group consisting of a bactericide and a repellent. 3. The aqueous gel composition according to claim 1, wherein the organic acid (d) is at least one selected from aliphatic oxymonocarboxylic acids and aliphatic dicarboxylic acids. 4. The aqueous gel composition according to claim 1, wherein the pH of the composition is from 3.0 to 6.0. 5. The content of carboxymethylcellulose and / or its sodium salt is 1.5 to 5.0% by weight.
Wherein the mixing ratio of the aluminum hydroxide gel is 95: 5 to 70:30 in terms of weight ratio of carboxymethyl cellulose and / or its sodium salt to Al ₂ O ₃ contained in the aluminum hydroxide gel. Terms 1, 2,
5. The aqueous gel composition according to 3 or 4.