JP2024006666A - Alcohol-based gel composition and method for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a highly practical gel composition with good productivity without requiring means such as heating while using an alcohol as a solvent to be gelatinized.

SOLUTION: There are provided: an alcohol-based gel composition comprising 3 to 9 mass% of hydroxyalkylalkyl cellulose, 55 to 70 mass% of a lower monoalcohol having 5 or less carbon atoms and 15 to 40 mass% of water; and a method for producing the same.

SELECTED DRAWING: None

COPYRIGHT: (C)2024,JPO&INPIT

Description

The present invention relates to an alcohol-based gel composition, and more particularly to an alcohol-based gel composition that uses alcohol as a main solvent and can be produced without heating, and a method for producing the same.

BACKGROUND ART Gel compositions prepared by using water or alcohol as a solvent and gelling with a gelling agent have been widely used in various fields. Gels that use alcohol as the main solvent have a lower freezing point than gels that use water as the main solvent, and can be used in freezers and cold regions because they have antifreeze effects in low-temperature environments. A gel composition can be obtained.
It is also useful when using alcohol itself as an active ingredient or when using in environments where water is disliked. However, there are few reports of practical techniques for gelling alcohol compared to water.

In order to obtain a lower alcohol-based gel while eliminating the above-mentioned problems, by adding acid to modified guar gum, which is a chemically modified form of guar gum, which is a polysaccharide, elasticity can be easily obtained at room temperature without any particular heating. A technique for obtaining a certain gel has been reported (Patent Document 1). However, since modified guar gum is derived from natural products, it is difficult to obtain modified guar gum that maintains a constant degree of modification of substituents. It was difficult to keep the physical properties constant. Furthermore, since the availability of guar gum derived from natural products tends to be unstable, there is a problem in that the availability of modified guar gum itself tends to be unstable.

The applicant has also proposed an alcohol gel using a mixture of hydroxyalkylcellulose and hydroxyalkylalkylcellulose (Patent Documents 2 and 3). However, in actual production, there are problems such as complicated handling during mixing and low productivity.

Japanese Patent Application Publication No. 2002-212298 Japanese Patent Application Publication No. 2017-177057 Japanese Patent Application Publication No. 2017-88679

The present invention has been made in view of the above-mentioned circumstances, and is a technology for obtaining a gel-like composition with high productivity and high practicality without requiring means such as heating, even though alcohol is used as a gelling solvent. The objective is to provide the following.

The present inventors have been researching techniques for gelling alcohol, and found that by adding a specific amount of hydroxyalkylcellulose, a water-soluble polymer, and water as a gelling agent, heating, etc. The present invention was completed based on the discovery that an alcohol-based gel composition can be obtained with high productivity at room temperature without performing the above steps, and is also highly practical.

That is, the present invention provides an alcohol-based gel containing 3 to 9% by mass of hydroxyalkylalkylcellulose, 55 to 70% by mass of lower monoalcohol having 5 or less carbon atoms, and 15 to 40% by mass of water. It is a composition.

Further, the present invention provides an alcohol-based gel characterized in that a solution consisting of hydroxyalkylalkyl cellulose and a lower monoalcohol having 5 or less carbon atoms is mixed with an aqueous solution containing a lower monoalcohol having 5 or less carbon atoms at room temperature. This is a method for producing a composition.

According to the present invention, it is possible to obtain an alcohol-based gel composition that has good productivity, is stable even at room temperature, and is practical. This gel-like composition shrinks due to volatilization of alcohol, water, and volatile components, and its end point is clear, so it can be used as a type of composition that volatilizes the components. Furthermore, since this gel-like composition has good powder dispersibility, it can also be used as a powder-containing composition.

a is the position of the upper end of the prepared gel, and b is the position of the top end of the gel surface after 5 minutes had elapsed since the gel was tipped on its side along with the beaker.

The alcohol-based gel composition of the present invention (hereinafter referred to as "the gel composition of the present invention") contains 3 to 9% by mass of hydroxyalkylalkylcellulose and 55 to 70% by mass of lower monoalcohol having 5 or less carbon atoms. , containing 15 to 40% by mass of water.

The gel-like composition of the present invention refers to a composition that uses an alcohol-containing solvent and has a gel-like appearance. In addition, "gel-like" means a state in which it has high viscosity and loses fluidity, and its appearance is generally called a gel.For example, prepare a total amount of 80 g of gel in a 100 ml beaker, and let it stand at room temperature for 20 minutes. The distance from the top of the gel after placing it there to the top of the gel surface after 5 minutes have passed since the gel was tipped sideways with the beaker is 21 mm or more and 25 mm or less, preferably 20 mm or less. .

The hydroxyalkylalkylcellulose (hereinafter abbreviated as "HAAC") used in the present invention is a nonionic water-soluble cellulose obtained by treating cellulose with caustic soda and then reacting it with an etherification agent such as alkyl chloride or alkylene oxide. It is a cellulose ether that has been made water-soluble by replacing some of the hydrogen atoms in the hydroxyl groups of cellulose with alkyl groups or hydroxyalkyl groups to eliminate hydrogen bonds. These HAACs can be used alone or in combination of two or more.

Specific examples of the above-mentioned HAAC include hydroxy _C2-4 alkyl _C1-4 alkyl cellulose such as hydroxyethyl methyl cellulose, hydroxyethyl ethyl cellulose, and hydroxypropyl methyl cellulose. Among these, hydroxypropyl methylcellulose (hereinafter abbreviated as "HPMC") is preferred.

The degree of substitution of HAAC used in the present invention, that is, the average number of hydroxyl groups substituted with alkoxyl groups present per glucose ring unit of cellulose, is not particularly limited, but is preferably 1.0 to 2.5, more preferably 1. It ranges from .5 to 2.5. Further, the number of moles of substitution, that is, the average number of moles of hydroxyalkoxy groups added per glucose ring unit of cellulose, is not particularly limited, but is preferably in the range of 0.05 to 0.40, more preferably 0.10 to 0.30. It is.

Further, the viscosity of the aqueous solution when the HAAC used in the present invention is dissolved in water is preferably 300 to 200,000 mPa·s, more preferably 3,000 to 100,000 mPa·s as a 2% aqueous solution viscosity. Note that the viscosity is a value measured using a B-type viscometer at 20°C.

Examples of the above-mentioned HPMC include Metrose manufactured by Shin-Etsu Chemical Co., Ltd., and the like. Examples of such Metrose include the Metrose SH series. Among the Metrose SH series, the Metrose 65SH series (degree of substitution 1.8, number of substituted moles 0.15, viscosity is plural) is preferred, and among these, Metrose 65SH-75000 is particularly preferred.

The content of HAAC in the gel composition of the present invention is 3 to 9% by mass (hereinafter simply referred to as %), preferably 4 to 6%.

Further, the lower monoalcohol having 5 or less carbon atoms (hereinafter simply referred to as "monoalcohol") used in the present invention is not particularly limited, but includes, for example, methanol, ethanol, propanol, isopropanol, n-butanol, isobutanol, sec. -butanol, tert-butanol, 2-methyl-1-propanol, 2-methyl-2-propanol, and pentanol. Among these, ethanol is preferred. Further, these monoalcohols can be used alone or in combination of two or more.

The content of monoalcohol in the gel composition of the present invention is 55 to 70%, preferably 60 to 65%.

Note that the mass ratio of HAAC to monoalcohol in the gel composition of the present invention is not particularly limited, but for example, HAAC:monoalcohol = 1:9 to 1:25, preferably 1:10 to 1:15. .

The water used in the present invention is not particularly limited, and for example, tap water, ion exchange water, etc. can be used.

The water content in the gel composition of the present invention is 15 to 40%, preferably 20 to 40%, and more preferably 25 to 35%.

The gel composition of the present invention further contains a nonionic surfactant for the purpose of dispersing the active ingredient or improving the releasability from the container wall as the solvent or volatile active ingredient evaporates. It is preferable to include it. Examples of nonionic surfactants include, but are not limited to, polyoxyethylene hydrogenated castor oil ether, polyoxyethylene alkyl ether, polyoxyethylene alkylene alkyl ether, polyoxyethylene de-styrenated phenyl ether, and polyoxyethylene tribenzyl. Examples include phenyl ether. Among these, polyoxyethylene hydrogenated castor oil ether is preferred, and polyoxyethylene (40) hydrogenated castor oil ether is particularly preferred. The HLB of these nonionic surfactants is not particularly limited, but is, for example, 10 to 15, preferably 12 to 14. These nonionic surfactants can be used alone or in combination of two or more.

The content of the nonionic surfactant in the gel composition of the present invention is not particularly limited, but is, for example, 0.05 to 10%, preferably 0.1 to 5%.

The gel-like composition of the present invention may contain glycerin in order to improve the releasability from the container wall due to the volatilization of the solvent or volatile active ingredient, and to suppress cracking of the gel and cause it to shrink into a similar shape. preferable.

The amount of glycerin blended in the gel composition of the present invention is not particularly limited, but is, for example, 0.05 to 10%, preferably 0.1 to 5%.

The gel composition of the present invention preferably contains active ingredients such as aroma ingredients, insecticidal ingredients, insect repellent ingredients, bactericidal ingredients, deodorizing ingredients, and deodorizing ingredients. Aromatic components include, but are not particularly limited to, fragrances, essential oils, and the like. Insecticidal ingredients, insect repellent ingredients, and bactericidal ingredients are not particularly limited, but include, for example, empenthrin, transfluthrin, allethrin, phenothrin, metofluthrin, profluthrin, paradichlorobenzene, naphthalene, camphor, 2-phenoxyethanol, chili pepper, burdock, cumin aldehyde, Examples include benzalkonium chloride and alkyltrimethylammonium chloride. Deodorizing components and deodorizing components are not particularly limited, but include, for example, aluminum sulfate, ammonium chloride, alum, copper sulfate, zinc sulfide, zinc stearate, aluminum stearate, titanium oxide, zinc oxide, flavonoid compounds, catechin, polyphenols, Examples include cyclodextrin, zeolite, layered zinc aluminosilicate, activated carbon, bincho charcoal, and the like. The form of these active ingredients is not particularly limited, but powders are preferred, and powders of chili pepper, layered zinc aluminosilicate, activated carbon, Bincho charcoal, and the like are more preferred. The size of the powder is not particularly limited, but for example, the average particle size (median diameter D50) is 0.1 μm to 500 μm, preferably 1 μm to 350 μm. These active ingredients can be used alone or in combination of two or more.

The content of the active ingredient in the gel composition of the present invention is not particularly limited, but is, for example, 0.01 to 10%, preferably 0.1 to 5%.

Furthermore, the gel composition of the present invention may optionally contain other gelling agents such as hydroxypropylated guar gum and hydroxyalkyl cellulose, and the above-mentioned nonionic surfactants, as long as they do not impede the effects of the present invention. Other emulsifying/dispersing components such as surfactants, pH adjusting components such as acids and alkalis, pigment components such as synthetic pigments and natural pigments, etc. can also be included.

Note that since HAAC is a nonionic compound, it has high selectivity with respect to added surfactants, volatile active ingredients, and the like. In addition, since HAAC has a very low base odor, it is less likely to be affected by perfumes and the like, and it is possible to obtain gel compositions that can be used with a wide range of volatile active ingredients. Further, due to the surfactant action of HAAC, it is possible to obtain a gel composition containing a volatile active ingredient such as a fragrance at a high concentration while suppressing the amount of surfactant added.

The gel composition of the present invention is produced by mixing a solution consisting of hydroxyalkylalkylcellulose and a monoalcohol with an aqueous solution containing a monoalcohol at room temperature (about 25°C) without any particular heating, and then homogenizing the solution. Manufactured by A solution consisting of hydroxyalkylalkyl cellulose and a monoalcohol is a highly fluid dispersion, but by adding an aqueous solution containing a monoalcohol, the entire composition gels.

In addition, the solution consisting of hydroxyalkylalkylcellulose and a monoalcohol or the aqueous solution containing a monoalcohol may optionally contain a nonionic surfactant, glycerin, an active ingredient, another gelling agent, and the nonionic surfactant. Other emulsifying/dispersing components such as surfactants, pH adjusting components such as acids and alkalis, pigment components such as synthetic pigments and natural pigments, etc. may be included. Further, the content of monoalcohol in the aqueous solution containing monoalcohol is preferably lower than the content of monoalcohol in the solution consisting of hydroxyalkylalkylcellulose and monoalcohol.

Preferred embodiments of the gel composition of the present invention include the following. In particular, this gel-like composition can be uniformly stirred, shows good gel-forming properties, and has high productivity, with little water separation from the gel and no gel remaining on the container wall as the solvent evaporates. It shrinks in shape, does not cause cracking of the gel during volatilization, and has excellent powder dispersibility.
Hydroxyalkyl alkylcellulose 4-6%
Lower monoalcohol with carbon number of 5 or less 55-65%
Water 25-35%
Nonionic surfactant 0.5-1%
Glycerin 0.5-1%
Active ingredient (powder) 0.1-2%

The gel composition of the present invention thus obtained is gelled by using HAAC, which can easily handle high-concentration alcohol without heating.

Further, in the process of preparing the gel composition of the present invention, it is also possible to prevent dangers such as explosions and fires due to overheating of alcohol. Furthermore, by blending alcohol at a high concentration of 50% or more, it is possible to have an insect repellent effect and an antifreeze effect in a low-temperature environment. Moreover, since gelation of the composition occurs by adding water during adjustment, a gel-like composition can be obtained safely and easily.

Furthermore, in the manufacturing process of the gel composition of the present invention, the gelation rate can be slowed down for a certain period of time, so there is no inconvenience that gelation occurs immediately after mixing and a uniform gel cannot be formed, and it is easy to handle in actual manufacturing sites. It is.

Due to the above-mentioned properties, the gel composition of the present invention can be used as a deodorizer, deodorizer, insect repellent, insecticide/insect repellent, bactericide, aromatic agent, etc. that volatilizes the ingredients, as well as a powder-containing type. It can be advantageously used as a deodorant, a deodorizing agent, an insect repellent, an insecticide/insect repellent, a bactericidal agent, an aromatic agent, and the like.

EXAMPLES Hereinafter, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited to these Examples in any way.

Implementation example 1
Preparation of gel composition and evaluation of physical properties:
A gel composition was prepared according to the composition (blending ratio) shown in Table 1 by the following manufacturing method. The physical properties of the obtained gel composition were evaluated according to the following evaluation criteria. The results are shown in Table 2.

[Manufacturing method]
At room temperature, pour a mixture of liquid A in the proportions shown in Table 1 below into a 100ml plastic beaker, and while stirring this liquid, add liquid B in the proportions to form a gel, resulting in 80 g. A gel-like composition was obtained.

[Evaluation of physical properties of gel composition]
The physical properties of the above gel composition were evaluated according to the following evaluation criteria.

(1) Gelation After stopping stirring for gel formation, the gel migration distance was measured as shown in FIG. 1 in a 100 ml beaker that was left standing at room temperature for 20 minutes, and gel formation was evaluated from this value. In other words, the distance (moved distance) from the top end of the prepared gel (a in the figure) to the position of the tip of the gel surface (b in the figure) after 5 minutes have passed since the gel was tipped sideways with the beaker. ) was measured and evaluated using the criteria below.
(Evaluation) (Content)
×... Cannot be gelled.
Δ: When the gel is laid down horizontally, the position of the gel tip after 5 minutes is 26 mm or more and 30 mm or less.
〇...The gel tip position after 5 minutes is 21 mm or more and 25 mm or less when laid down.
◎...The gel tip position after 5 minutes is 20 mm or less when laid down.

(2) Productivity The state of gelation during gel production was evaluated using the following criteria.
(Evaluation) (Content)
◎...Can be uniformly gelled even after mixing.
〇…Gelation is somewhat quick, but it can be gelled uniformly.
×... It gels immediately and does not become a uniform gel.

(3) Mold releasability While the gel was shrinking as the solvent evaporated, the releasability of the gel on the wall of the container was evaluated using the following criteria.
(Evaluation) (Content)
◎...The mold was released without leaving any gel from the wall of the container.
〇…Some gel remained on the wall of the container.
x: Gel remained on the wall of the container and the mold was not released.

(4) Gel cracking During gel contraction due to solvent volatilization, gel cracking was evaluated based on the following criteria.
(Evaluation) (Content)
◎…Gel cracking does not occur in all samples until the final stage of volatilization.
〇…Gel cracks may occur slightly during volatilization in some samples, but this does not affect use.
×... Gel cracks occur during volatilization of all samples.

(5) Dispersibility of powder The dispersibility of chili pepper powder in the gel was evaluated according to the following criteria.
(Evaluation) (Content)
○... Uniformly dispersed in the gel.
x: Not dispersed in the gel.

As is clear from the results of the above examples, the gel composition of the present invention has excellent gelation properties, productivity, mold release properties, gel cracking, and dispersibility of powder in the gel. was able to form. Note that for Comparative Products 1 to 3, since gelation was not possible, evaluation of productivity, mold releasability, and gel cracking was not performed. Furthermore, since the productivity of Comparative Products 4 and 5 was rated as x, evaluation of mold releasability and gel cracking was not performed.

Implementation example 2
Preparation example:
A gel insect repellent of the present invention was prepared using the composition shown in Table 3 (numbers in the table are in g) and by the same manufacturing method as in Example 1. All of them can be stirred uniformly, show good gel-forming properties, and have high productivity.As the solvent evaporates, the gel does not remain on the container wall and contracts into a similar shape. No cracking occurred, and the dispersibility of the powder was excellent. Therefore, a preparation with high utility value could be obtained.

Implementation example 3
Preparation example:
A gel fragrance of the present invention was prepared using the composition shown in Table 4 (numbers in the table are in g) and by the same manufacturing method as in Example 1. All of them can be stirred uniformly, show good gel-forming properties, and have high productivity.As the solvent evaporates, the gel does not remain on the container wall and contracts into a similar shape. No cracking occurred. Therefore, a preparation with high utility value could be obtained.

Implementation example 4
Preparation example:
A gel deodorizer of the present invention was prepared by the same method as in Example 1 using the composition shown in Table 5 (numbers in the table are in g). All of them can be stirred uniformly, show good gel-forming properties, and have high productivity.As the solvent evaporates, the gel does not remain on the container wall and contracts into a similar shape. No cracking occurred, and the dispersibility of the powder was excellent. Therefore, a preparation with high utility value could be obtained.

The gel composition of the present invention has high productivity, and the composition shrinks due to the volatilization of alcohol, water, etc., and its end point is clear, so it is highly practical, and is a type of deodorant that volatilizes the ingredients. , Deodorant, insect repellent, insecticide/insect repellent, bactericide, fragrance, powder-containing deodorant, deodorizer, insect repellent, insecticide/insect repellent, bactericide, fragrance, etc. It is something that can be done.

Claims (12)

3 to 9% by mass of hydroxyalkylalkylcellulose,
55 to 70% by mass of lower monoalcohols having 5 or less carbon atoms,
An alcoholic gel composition characterized by containing 15 to 40% by mass of water. The alcoholic gel composition according to claim 1, wherein the _{hydroxyalkylalkylcellulose} is _{hydroxyC2-4alkylC1-4alkylcellulose} . The alcohol-based gel composition according to claim 2, wherein the hydroxy _C2-4 alkyl _C1-4 alkyl cellulose is hydroxypropyl methylcellulose. The alcohol gel composition according to any one of claims 1 to 3, further comprising a nonionic surfactant. The alcoholic gel composition according to claim 4, wherein the content of the nonionic surfactant is 0.05 to 10% by mass. The alcohol-based gel composition according to any one of claims 1 to 3, further comprising glycerin. The alcohol-based gel composition according to claim 6, wherein the content of glycerin is 0.05 to 10% by mass. The composition according to any one of claims 1 to 3 further contains one or more active ingredients selected from the group consisting of an aromatic component, an insecticidal component, an insect repellent component, a bactericidal component, a deodorizing component, and a deodorizing component. The alcoholic gel composition described above. The alcoholic gel composition according to claim 8, wherein the active ingredient is in powder form. The alcoholic gel composition according to claim 8, wherein the content of the active ingredient is 0.01 to 10% by mass. The alcoholic gel composition according to any one of claims 1 to 3, wherein the mass ratio of hydroxyalkylalkylcellulose to lower monoalcohol having 5 or less carbon atoms is 1:9 to 1:25. The alcohol-based gel according to claim 1, characterized in that a solution consisting of hydroxyalkylalkyl cellulose and a lower monoalcohol having 5 or less carbon atoms and an aqueous solution containing a lower monoalcohol having 5 or less carbon atoms are mixed at room temperature. A method for producing a composition.

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