JP2002249665A - Emulsified composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an emulsified composition being formulated with urea and/or a glycoside of ascorbic acid, the composition having an excellent stability and refreshed feeling without stickiness in case of use. SOLUTION: In the emulsified composition being formulated with 0.05 to 50.0 wt.% of urea and/or the glycoside of ascorbic acid, the composition is formulated with (A) 0.01 to 5.0 wt.% of a polysiloxane-polyoxyalkylene copolymer and (B) 0.05 to 1.0 wt.% of a non-ionic surfactant or 0.05 to 5.0 wt.% of a higher fatty acid having at least 12 carbon atoms. Further, the composition is formulated with (C) 0.01 to 1.0 wt.% of a chelating agent, and also (D) 10.0 to 30.0 wt.% of a humectant.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an emulsion composition,
In particular, the present invention relates to an emulsion composition containing a glycoside of urea and / or ascorbic acid, which is excellent in stability, has no sticky feeling, and has a refreshing use feeling.

[0002]

2. Description of the Related Art Skin care cosmetics and skin external preparations maintain a beautiful skin condition,
In order to prevent and improve rough skin, use natural moisturizing factors (NM
F: natural moisturing factor) or a humectant is used. Among the natural moisturizing factors, urea is a component well-known as having a keratin layer softening effect and a skin roughness improving effect.

However, a system containing urea has a problem that it sometimes causes skin irritation such as tingling. In such a case, there is a method of suppressing the sticking due to urea by adding a lot of humectants. However, when the humectant is blended in a large amount, the cosmetic is highly sticky when applied to the skin due to the high viscosity and moisturizing properties of the humectant itself, and the usability is reduced. Also, since urea itself is sticky, there is a disadvantage that even when urea is blended in a large amount, the stickiness is high and the usability is poor.

On the other hand, glycosides of ascorbic acid are blended in an emulsified composition as a whitening component or a component for preventing rough skin. This ascorbic acid glycoside is itself a sticky drug, and the composition containing ascorbic acid glycosides also has the drawback of poor usability similarly to the composition containing urea.

Further, it is known that glucosides of urea and ascorbic acid and the like are decomposed with the passage of time, which causes coloring and unpleasant odor of the preparation. As a method for solving this, it is conceivable to add a chelating agent such as EDTA. However, in the case of an emulsion-based preparation, there has been a problem that the addition of the chelating agent deteriorates the stability of the preparation. On the other hand, it is known to stabilize the preparation by blending a water-soluble polymer such as carboxyvinyl polymer or xanthan gum or a clay mineral, but in many cases, a sufficient effect cannot be obtained. Even when the stabilizer is added, there is a peculiar feeling of sliminess and stickiness, and there is a problem in usability.

On the other hand, in emulsifying cosmetics, a surfactant is used as an emulsifier, but it is desired to use a surfactant in the lowest possible amount for safety.

Under such circumstances, a composition containing urea and ascorbic acid glycosides has excellent emulsifying power even when the amount of surfactant is reduced, and is stable and sticky. There has been a demand for an emulsion preparation having good usability.

The present invention has been made in view of the above-mentioned conventional circumstances, and is an emulsion composition containing a urea and / or ascorbic acid glycoside, which is excellent in stability and usability. An object is to provide a good emulsion composition.

[0009]

Means for Solving the Problems The present inventors have made intensive studies to solve the above problems, and as a result, have found that a polysiloxane-polyoxyalkylene copolymer and a nonionic surfactant or a higher fatty acid are used. It has been found that the emulsified composition obtained by containing a specific amount has excellent stability and good usability even when a glucoside of urea and / or ascorbic acid is blended. It was completed.

That is, the present invention relates to an emulsion composition containing 0.05 to 50.0% by mass of a glycoside of urea and / or ascorbic acid. 0.01 to 5.0% by mass
And (B) 0.05 to 1.0% by mass of a nonionic surfactant
Or 0.05 to higher fatty acids having 12 or more carbon atoms
An emulsified composition characterized by being blended with 5.0% by mass.

Hereinafter, the present invention will be described in detail. The urea used in the present invention is represented by the chemical formula: H ₂ CONH ₂ and may be arbitrarily used as long as it can be used in the cosmetics and pharmaceutical fields. Examples of ascorbic acid glycoside include ascorbic acid glucoside, ascorbic acid diglucoside, and ascorbic acid triglucoside.

The compounding amount of urea or ascorbic acid glycoside in the composition of the present invention is suitably 0.05 to 50.0% by mass, particularly 1.0 to 50.0% by mass, preferably 2 to 50.0% by mass. 0.0 to 20.0% by mass.

In the present invention, by blending a polysiloxane-polyoxyalkylene copolymer with a preparation containing urea or ascorbic acid glycosides, it is possible to greatly reduce the amount of the surfactant, In addition, the tackiness of urea or ascorbic acid glycosides per se can be significantly reduced. Accordingly, an emulsified composition having good usability without stickiness can be prepared even if a large amount of humectant is blended.

As the polysiloxane-polyoxyalkylene copolymer as the component (A) contained in the emulsion composition of the present invention, a copolymer represented by the following general formula (1) is preferably used.

[0015]

Embedded image

Wherein A represents an alkyl group having 1 to 6 carbon atoms, a phenyl group or B described below, and B represents a general formula:
_{-C 3 H 6 O (C 2} H 4 O) a (C 3 H 6 O) bR '( where, R' is selected from hydrogen atom, an acyl group, and the group consisting of alkyl group having 1 to 6 carbon atoms A is 0
And b is an integer of 0 to 50. However, a and b do not become 0 at the same time. And R is each independently an alkyl group having 1 to 6 carbon atoms or a phenyl group;
Is an integer of 50 to 1000, and n is an integer of 0 to 50. However, at least one has a polyoxyalkylene group in the molecule. ]

In the above, n is preferably at least 1. R preferably represents a methyl group.

The component (A) is produced by reacting a polyoxyalkylene compound having a double bond group at a terminal with a siloxane compound having a hydrosilyl group terminal which reacts with a reactive terminal group of the polyoxyalkylene compound. However, the present invention is not limited to this. The component (A) is, for example, “Silicone KF601”
7 "(manufactured by Shin-Etsu Chemical Co., Ltd.) and the like, and are commercially available.

The amount of component (A) in the composition of the present invention
0.01 to 5.0% by mass, preferably 0.1 to 5.0% by mass.
1.0% by mass. If the amount is less than 0.01% by mass, the emulsion stability is poor, and if the amount is more than 5.0% by mass, problems arise in usability such as poor elongation.

As the component (B), a nonionic surfactant and / or a higher fatty acid having 12 or more carbon atoms is used. The higher fatty acids preferably have 12 carbon atoms.
As described above, the number of carbon atoms is 35 or less. All of these components are used together with the component (A) to assist emulsification and increase the stability of the system.

The nonionic surfactant as the component (B) is generally used in cosmetics, and a hydrophilic nonionic surfactant is preferably used. In the present invention, these surfactants preferably have an HLB of 9 or more.

Examples of the hydrophilic nonionic surfactant include PO
E sorbitan monooleate, POE sorbitan monostearate, POE sorbitan monolaurate, POE
POE sorbitan fatty acid esters such as sorbitan tetraoleate, POE sorbit monolaurate, POE
P such as E sorbit monooleate, POE sorbit pentaoleate, POE sorbit monostearate
OE sorbit fatty acid esters, POE glycerin fatty acid esters such as POE glycerin monostearate, POE glycerin triisostearate, POE fatty acid esters such as POE monooleate, POE alkyl ethers such as POE lauryl ether, POE octyl phenyl ether, etc. POE such as POE alkyl phenyl ethers and POE / POP cetyl ether
OP alkyl ethers, tetra POE, tetra POE
Ethylenediamine condensates, POE castor oil or hydrogenated castor oil derivatives, POE beeswax lanolin derivatives, alkanolamides such as lauric acid monoethanolamide, POE propylene glycol fatty acid ester, POE
E alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, trioleyl phosphoric acid, polyglycerin fatty acid ester and the like.

The compounding amount of the nonionic surfactant is 0.05 to 1.0% by mass, preferably 0.1 to 0.5% by mass in the composition of the present invention. In the present invention, an excellent emulsifying effect can be obtained even when the component (B) is used in such a low amount.

As the higher fatty acid having 12 or more carbon atoms as the component (B), for example, lauric acid, myristic acid, palmitic acid, stearic acid, behen (behenin)
Acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA),
Docosahexaenoic acid (DHA), capric acid, lanolin fatty acid and the like.

The compounding amount of the higher fatty acid having 12 or more carbon atoms is 0.05 to 5.0% by mass, preferably 0.1 to 3.0% by mass in the composition of the present invention. 0.05
If the amount is less than 5% by mass, the emulsion stability is poor. If the amount exceeds 5.0% by mass, problems such as irritation occur.

The chelating agent of the component (C) is an optional component. As described above, the chelating agent is preferably added in order to prevent urea, ascorbic acid or a derivative thereof from decomposing over time, and to prevent coloring and unpleasant odor of the preparation.

Examples of such chelating agents include edetate, hexametaphosphate and the like. (C) A preferable compounding amount of the chelating agent is 0.01 to 1.0% by mass.

The humectant as the component (D) is an optional component, and may include everything that can be usually blended in cosmetics. Specific examples include polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, chitosan, and the like. Of course, it is not limited. One or more humectants can be selected and used.

(D) The compounding amount of the humectant in the composition of the present invention is suitably 10.0 to 30.0% by mass, and preferably 10.0 to 15.0% by mass. In the present invention, even when the humectant is used in such a high content, there is no sticky feeling and an excellent feeling of use (freshness). Therefore, it is possible to prepare an emulsified preparation having an excellent use feeling (freshness, moistness) even when a large amount of a humectant is blended in order to reduce the burning and irritation of urea.

The emulsion composition of the present invention contains an oil component, and preferably at least 70.0% by mass of the total oil component is silicone oil. 70.0% by mass of total oil
By using silicone oil as the above, it is possible to have a lighter feeling of use.

The silicone may be a nonvolatile silicone oil or a volatile silicone oil. For example, chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, decamethylpolysiloxane, dodecamethyl Examples thereof include cyclic polysiloxanes such as polysiloxane and tetramethyltetrahydrogenpolysiloxane.

Other oils include, for example, hydrocarbons such as liquid paraffin, squalane and petrolatum; fats and oils such as avocado oil, camellia oil, macadamia nut oil, olive oil and lanolin; waxes such as jojoba oil, carnauba wax and candelilla wax. And higher alcohols such as caprylic alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, phytosterol; ester oils such as cetyl isooctanoate, isopropyl myristate, myristyl myristate, diethyl sebacate, isopropyl adipate; medium chain fatty acids Examples include esters and triglycerides such as glycerin triisooctanoate.

The emulsified composition of the present invention can be used for basic cosmetics such as lotion, milky lotion, cream, pack, etc., makeup cosmetics such as lipstick, foundation, etc., hair products such as shampoo, rinse and hair dye, suntan. It covers many kinds of cosmetics, such as special cosmetics such as stop.

The emulsion composition of the present invention contains, besides the above-mentioned essential components, other components which are usually used in external preparations such as cosmetics and pharmaceuticals, such as wetting agents, oxidizing agents, etc., so long as the effects of the present invention are not impaired. Inhibitors, other surfactants, preservatives, amino acids, fragrances, alcohols, coloring agents, powders, drugs and the like can be appropriately compounded as required.

Specifically, lower alcohols such as ethanol: antioxidants such as butylhydroxytoluene, tocopherol, and phytin; benzoic acid, salicylic acid,
Antibacterial agents such as sorbic acid, alkyl paraoxybenzoate, and hexachlorophene, and powders such as nylon powder, polyethylene powder, and silica can be blended.

Further, for example, a paraaminobenzoic acid-based ultraviolet absorber, an anthranilic acid-based ultraviolet absorber, a salicylic acid-based ultraviolet absorber, a cinnamic acid-based ultraviolet absorber, a benzophenone-based ultraviolet absorber, a sugar-based ultraviolet absorber, 3- ( 4'-methylbenzylidene) -d-camphor, 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methyl Phenylbenzotriazole, 2- (2′-hydroxy-5′-t
-Octylphenyl) benzotriazole, 2- (2 ′
-Hydroxy-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,
An ultraviolet absorber such as 3-dimethyl-2-norbornylidene) -3-bentan-2-one can be blended.

Also, for example, amino acids such as glycine, alanine, valine, leucine, threonine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, arginine, histidine and the like, and alkali metal salts and hydrochlorides thereof; acyl sarcosine acids (eg, Organic acids such as glutathione, citric acid, malic acid, tartaric acid, and lactic acid; vitamin A and its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B12 ,
Vitamin B such as vitamin B15 and its derivatives, α-
Vitamin E such as tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, vitamins such as pantothenic acid, pantethine; nicotinamide, benzyl nicotinate, γ
-Oryzanol, allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, bisabolol, eucalptone, thymol,
Saponins such as inositol, saikosaponin, carrot saponin, hemimasaponin, muclodisaponin, pantothenyl ethyl ether, ethinyl estradiol,
Various drugs such as tranexamic acid, arbutin, cepharanthin, placenta extract and the like can be added.

Also, for example, Rumex, Clara, Kouhone, Orange, Sage, Yarrow, Zeniaoi, Assembly, Thyme, Touki, Spruce, Birch, Japanese horsetail, Loofah, Malonier, Yukinoshita, Arnica, Yuri, Artemisia, Peony, Aloe, Gardenia, Plant extracts, pigments, neutralizing agents, antioxidants, etc.
Perfume, purified water and the like can be blended.

[0039]

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto. In addition, the compounding amount is mass%.

Examples 1 to 17, Comparative Examples 1 to 18 Creams or emulsions having the compositions shown in Tables 1 to 8 below were obtained by a conventional method. Using this, an actual use test (moist feeling, dry feeling, tingling feeling) was performed. The skin conductance value, emulsion stability, and discoloration or odor were also evaluated. The results are shown in Tables 1 to 8.

In Tables 1 to 8, "Polysiloxane-
"Polyoxyalkylene copolymer" is manufactured by Shin-Etsu Chemical Co., Ltd.
6017 (molecular weight about 6000).

(1) Actual use test A sample was actually applied to the skin by ten women-only panels, and the samples were evaluated for moistness, dryness (non-stickiness), and tingling according to the following criteria.

Moist feeling (Evaluation criteria) ：: Eight or more people evaluated moist feeling Δ: 3 to 7 people evaluated moist feeling ×: Two or less evaluated moist feeling

Dry feeling (non-stickiness) (Evaluation criteria) ：: Eight or more people evaluated that there was a dry feeling (not sticky) Δ: Three to seven people evaluated that there was a dry feeling (non-sticky) × : 2 or less people felt that there was a feeling of smoothness (not sticky)

Severing feeling (Evaluation criteria) ：: Eight or more persons evaluated that there was no feeling of swelling Δ: 3 to 7 persons evaluated that there was no feeling of swelling ×: Two or less persons showed the feeling of swelling Not rated

(2) Skin conductance value Each sample was applied to a specific part of the skin once a day, left for 3 minutes, washed with purified water, and wiped with absorbent cotton. This operation was repeated for two weeks, and the skin conductance at the application site was measured.

(3) Emulsion stability After each sample was stored at 50 ° C. for one month, the state of emulsification was visually observed. (Evaluation criteria) ：: No separation was observed at all, and the emulsion was in a good emulsified state. X: Separation was observed.

(4) Discoloration or Odor After each sample was stored at 50 ° C. for one month, the state of discoloration or odor was visually observed. (Evaluation criteria) ：: No discoloration or odor. ×: Discoloration or odor is present.

[0049]

[Table 1]

[0050]

[Table 2]

[0051]

[Table 3]

[0052]

[Table 4]

[0053]

[Table 5]

[0054]

[Table 6]

[0055]

[Table 7]

[0056]

[Table 8]

Examples 18 to 25 and Comparative Examples 19 to 26 Creams or emulsions having the compositions shown in Tables 9 to 12 below were obtained by a conventional method. Using this, practical use tests (no stickiness) and emulsion stability were evaluated. The results are shown in Tables 9 to 12.

In Tables 9 to 12, "dimethylpolysiloxane (polyoxyethylene) copolymer" used was KF6017 manufactured by Shin-Etsu Chemical Co. (molecular weight: about 6,000).

(1) Actual Use Test A sample was actually applied to the skin by 10 women-only panels, and the non-stickiness was evaluated according to the following criteria.

Non-stickiness (Evaluation criteria) ○: Two or less people feel sticky ×: Half or more people feel sticky

(2) Emulsion Stability After each sample was stored at 50 ° C. for one month, the state of emulsification was visually observed. (Evaluation criteria) ○: No abnormality ×: Separation or water separation was observed

[0062]

[Table 9]

[0063]

[Table 10]

[0064]

[Table 11]

[0065]

[Table 12]

[0066]

As described above in detail, according to the present invention, in an emulsified composition containing urea or ascorbic acid glycoside, excellent emulsifying power can be obtained without adding or using a low surfactant. An emulsified composition having good usability and having no stickiness even when a humectant is blended in a large amount is provided.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification code FI Theme coat ゛ (Reference) A61K 7/48 A61K 7/48 C08K 5/09 C08K 5/09 5/1535 5/1535 5/21 5 / 21 C08L 71/02 C08L 71/02 F term (reference) 4C083 AB032 AB172 AB442 AC012 AC022 AC072 AC122 AC242 AC302 AC352 AC432 AC442 AC472 AC482 AC532 AC681 AC682 AD022 AD092 AD151 AD152 AD161 AD162 AD352 AD641 AD642 BB04 CC05 DD31 EE01 EE06 EE06 CH012 CH05Z CP031 CP18Y EC058 EH057 EL066 EP017 ER026 FD202 FD208 FD31Z FD317 GB00 GB01

Claims (5)

[Claims] 1. An emulsified composition containing 0.05 to 50.0% by mass of a glycoside of urea and / or ascorbic acid, wherein (A) a polysiloxane-polyoxyalkylene copolymer 0.01 to 5 0.0% by mass and (B) 0.05 to 1.0% by mass of a nonionic surfactant or 0.05 to 5.0% by mass of a higher fatty acid having 12 or more carbon atoms. An emulsified composition characterized by the following: 2. The emulsion composition according to claim 1, further comprising (C) 0.01 to 1.0% by mass of a chelating agent. 3. The emulsion composition according to claim 1, further comprising (D) 10.0 to 30.0% by mass of a humectant. 4. The emulsion composition according to claim 1, wherein the component (A) is a copolymer represented by the following general formula (1). Embedded image [In the formula, A represents an alkyl group having 1 to 6 carbon atoms, a phenyl group or a later-described B, B has the general _formula: -C _{3 H} 6 O
_{(C 2 H 4 O) a} (C 3 H 6 O) bR '( where, R' is hydrogen atom, an acyl group, and a group selected from the group consisting of alkyl group having 1 to 6 carbon atoms, a is an integer of 0 to 50, b is an integer of 0 to 50, provided that a and b are not simultaneously 0.), and R is each independently a carbon atom 1 to 6 atoms
M is 50 to 10
00 is an integer, and n is an integer of 0 to 50. However, at least one has a polyoxyalkylene group in the molecule. ] 5. The emulsion composition according to claim 1, wherein one or more silicone oils are blended in an amount of 70.0% by mass or more based on the total oil content.