JP2002226383A - Skin care preparation having, long-acting antimicrobial spectrum of wide range - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve the problem that a greater number of kinds of microorganisms are found in atopic dermatitis patients than those in normal healthy subjects and not a dew of them are changed into allergens, i.e., a wide range of microorganisms started from Staphylococcus aureus and fungi such as Candida albicans, Alternaria, Malassezia further to bacteria may be cited, consequently, thus a skin care preparation capable of nonspecifically eliminating the wide range of these microorganisms in order to treat eczematous dermatitises is needed. SOLUTION: This skin care preparation having a long-acting antimicrobial spectrum of wide range is characterized in that the long-acting skin care preparation comprises 0.1 wt.% to 10 wt.% of an antimicrobial sintered ceramic (antimicrobial silver ceramic, for short, containing silver, tricalcium phosphate, zinc oxide and silicon dioxide), 0.01-0.05 wt.% of hinokitiol (β-thujaplicin) and 0.01-0.5 wt.% of an essential oil (tea tree oil) of Melaleuca alternifolia leaf.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention provides an external preparation for skin for removing microorganisms such as Staphylococcus aureus and Candida albicans that exacerbate eczema dermatitis.

[0002]

2. Description of the Related Art Techniques for removing skin microorganisms include:
The main topic is an external preparation containing an antibiotic or a sulfa drug, and an external preparation containing an antiseptic disinfectant such as benzoic acid or a salt thereof, thianthol, biosol, wood vinegar or bamboo vinegar.

[0003]

According to reports, many types of microorganisms have been found in patients with atopic dermatitis as compared with healthy individuals, and many of them have been simultaneously transferred to allergens. The list is wide ranging from fungi to bacteria such as Staphylococcus aureus, Candida albicans, Alternaria, Malassezia fafa etc. Therefore, in order to treat eczema-type dermatitis, a skin external preparation that can remove all of these various microorganisms is desired. There has been an external preparation containing an antibiotic as the most effective means, but due to the narrow antibacterial spectrum and the emergence of resistant bacteria to each antibiotic in recent years, the situation concerning infection with skin microorganisms has become extremely confusing. In particular, the appearance of methicillin-resistant Staphylococcus aureus has made eczema dermatitis refractory. Also, benzoic acid has a problem of causing histamine-releasing dermatitis even at a low concentration of 0.1%, and thiantol and biosol have a problem of skin sensitization, and hinokitiol and Melaleuca alt.
Even if essential oil of ernifolia leaves is applied at a high concentration, there is a problem in safety. In addition, there is also a problem that the durability after external application to the skin is short.

[0004]

[Means for Solving the Problems] Sustained broad spectrum antimicrobial spectrum skin external preparation

The present invention relates to an antibacterial sintered ceramic (hereinafter referred to as antibacterial silver ceramic: containing silver and tricalcium phosphate, zinc oxide and silicon dioxide) of from 0.1% to 10% by weight and 0.01% by weight. To 0.05% by weight of hinokitiol (β-thyaprisin) and 0.01% to 0.5% by weight of Melaleuca alternif
It is a persistent broad-spectrum antimicrobial spectrum skin external preparation characterized by blending essential oils of tea leaves (tea tory oil). Treat the skin. The external preparation is applied to any of cosmetics, quasi-drugs, and pharmaceuticals. The dosage form is applied to various dosage forms such as a gel form, a cream form, a cataplasm, a lotion and the like. In order to assist its effect, humectants such as ethanol, glycerin, and 1,3-butylene glycol are used as bases, and various powders such as zinc white and cellulose powder are used as drying agents, and anti-inflammatory substances such as diphenhydramine and glycyrrhizic acid are used. And a disinfectant such as salicylic acid may be used in combination. It is also useful to add a dust mite repellent substance for atopic dermatitis.

[0006]

EXAMPLE 1 Example 1 is described and details of the present invention are described. The formulation of Example 1 is described in Table 1. Example 1 is applied to the skin by shaking immediately before use.

[0007]

[Table 1]

The antimicrobial effect of Example 1 was examined at the minimum inhibitory concentration. Seven kinds of microorganisms were used, from 10 6 to 7
The test was carried out according to a standard method by adjusting the number of suspensions. In the examples, a test was carried out using a dispersion serially diluted with purified water while shaking other test substances. At the same time, the examples also carried out samples exposed to sunlight for 8 hours. Table 2 shows the results. The examples showed inhibition at even more diluted concentrations, relative to the minimum inhibitory concentration of each test substance alone. The examples showed a broad spectrum of antimicrobial activity from quorum positive and negative bacteria to fungi. Hinokitiol was weak to light and lost its effect after exposure to 8 hours of sunlight in this test, but Example 1 was effective at a lower concentration than the test substance alone under the same conditions. The synergistic effect and persistence of the mixture were confirmed.

[0009]

[Table 2]

[0010]

Using Example 1, a clinical test was conducted on a total of 57 patients with atopic dermatitis or dermatitis due to Staphylococcus aureus infection (hereinafter referred to as Tobii) and scabies.
Among the atopic dermatitis cases, 38 were excellent in 30 cases, effective in 3 cases, slightly effective in 4 cases, and ineffective in 1 case. On the other hand, 1
Among 2 cases, 10 cases were excellent, 1 case was effective, 1 case was fairly effective, and there was no ineffectiveness. In 3 cases of scabies, 1 case was excellent, 1 case was effective, 1 case was somewhat effective, and there was no ineffectiveness. Further, in eczema-type dermatitis of unknown cause, 1 out of 4 cases was excellent, 1 was effective, 1 was slightly effective, and there was no invalid. When all the cases were summarized to be somewhat effective or more effective, about 98% showed an effect, and there were no side effects or worsened cases.

Claims (1)

[Claims] 1. An antibacterial sintered ceramic (hereinafter referred to as antibacterial silver ceramic containing silver and tricalcium phosphate, zinc oxide and silicon dioxide) of from 0.1% to 10% by weight and from 0.01% to 0% by weight. 0.15% by weight of hinokitiol (β-thyaprisin) and 0.01% to 0.5% by weight of essential oil of leaf of Melaleuca alternifolia (tea tree oil). External preparation.