JP2002212059A - Bathing composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a bathing composition capable of imparting a moist feeling and smoothness to the skin, ameliorating aging of the skin such as firmness or texture of the skin and having even excellent warming effects on the body. SOLUTION: This bathing composition is characterized as comprising a water-soluble extract of Ribes nigrum (except a seed oil of the Ribes nigrum).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bath composition having an effect of improving skin condition. For more information,
Natural ingredient, Maillard reaction inhibitory effect, whitening effect,
Incorporates a water-soluble cassis extract with excellent anti-inflammatory effects, active oxygen suppression effects, and lipid peroxide production suppression effects to inactivate lipid peroxides on the skin and suppress inflammation due to external stress such as ultraviolet rays And a bath composition for improving the condition of the skin.

[0002]

2. Description of the Related Art Conventionally, as shown in the examples of JP-A-7-165530 and JP-A-8-34722, a preparation containing black currant (seed) oil, which is the Japanese name of cassis, is not known. It is known.

[0003]

However, these publications disclose that the water-soluble cassis extract has excellent Maillard reaction inhibitory effect, whitening effect, anti-inflammatory effect, active oxygen inhibitory effect, and lipid peroxide formation inhibitory effect. No effect is described. Further, it is not described that a bath composition containing a water-soluble cassis extract has an effect of improving skin condition. On the other hand, various bath compositions have been proposed, but few can sufficiently improve skin aging and inflammation.

[0004]

Means for Solving the Problems The present inventors have thought that cassis is a kind of pepper and can expect some physiological activity, and conducted intensive studies on the physiologically active effect of the water-soluble cassis extract. Various excellent effects, such as Maillard reaction inhibitory effect, whitening effect, anti-inflammatory effect,
It has been found that they exhibit excellent performance in suppressing the active oxygen and lipid peroxide production. In particular, it has been found that the Maillard reaction inhibitory effect has performance belonging to the most effective class among known plant extracts. Then, when this water-soluble cassis extract was blended into a bath composition, it was found that the skin was moist and smooth, and a bath composition excellent in touch was obtained, and the present invention was completed.

That is, the present invention is a bath composition characterized by containing a water-soluble cassis extract (provided that black currant seed oil is used).

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION Cassis used in the present invention is a plant represented by the Japanese name black currant and the scientific name Ribes nigrum. In the present invention, any portion of cassis fruit, flowers, seeds, leaves, stems, roots and the like may be used, but it is preferable to use fruits and seeds that are commercially available and easily available. . For example, in the distribution for food, those distributed under the names such as black currant, redcurrant, and blackcurrant are preferable because they are easily available.

The cassis extract used in the present invention is a water-soluble one. Therefore, oily components such as black currant seed oil are excluded. Examples of the cassis extraction solvent include hydrophilic solvents such as water, ethanol, 1,3-butylene glycol, glycerin, and a mixed solvent thereof. Extraction is performed using these solvents, and after extraction, purification treatment with activated carbon or the like is performed. May be applied. In the present invention, a liquid containing the extracted solvent,
Alternatively, it is used as a pure component excluding the solvent, or as a solution in which the pure component is dissolved in a solvent. Production examples of the water-soluble cassis extract used in the present invention are shown below. The dried cassis (black currant) was immersed in a 10-fold volume of 50% by volume butylene glycol, allowed to stand for one week, and then filtered. The evaporation residue of this solution was measured and treated with an equal amount of activated carbon to obtain a cassis extract. The dried cassis (black currant) was immersed in a 10-fold amount of 50% by volume ethyl alcohol, allowed to stand for one week, and then filtered. The evaporation residue of this solution was measured and treated with an equal amount of activated carbon to obtain a cassis extract. The dried cassis (black currant) was immersed in a 10-fold amount of purified water, allowed to stand for one week, filtered, activated carbon treated, and sterilized by a membrane filter to obtain a cassis extract.

The mixing ratio of the water-soluble cassis extract to the bath composition of the present invention is preferably 0.001 to 99 parts by mass per 100 parts by mass of the bath composition (in terms of dry residue), More preferably, it is 0.01 to 30 parts by mass.

[0009] In the bath composition of the present invention, it is preferable to use a physiologically active ingredient together. The term "bioactive component" as used herein means a substance that gives some physiological activity to the skin when applied to the skin. For example, anti-inflammatory agents, anti-aging agents, slimming agents, tightening agents, antioxidants, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, cooling sensation agents, warming sensation agents,
Vitamins, amino acids, wound healing promoters, stimulants,
Examples include an analgesic, a cell activator, an enzyme component, and the like. Among them, natural plant extract components, seaweed extract components, crude drug components, and enzyme components are particularly preferable. In the present invention, it is preferable to mix one or more of these physiologically active ingredients.

Examples of these components include, for example, ashitaba extract, avocado extract, amacha extract, altea extract, arnica extract, aloe extract, apricot extract, apricot nucleus extract, ginkgo extract, fennel extract, turmeric extract, oolong tea extract, and Eijitsu Extracts, Echinashi leaf extract, oak extract, oak extract, spinach extract, barley extract, hypericum extract, scotch extract, Dutch mustard extract, orange extract, seawater dried product, seaweed extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk , Chamomile extract, carrot extract, sagebrush extract, licorice extract, calcade extract, syllium extract, kiwi extract, kina extract, cucumber extract, guanosine,
Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Grapefruit extract, Clematis extract, Chlorella extract, Mulberry extract, Gentian extract,
Black tea extract, yeast extract, burdock extract, rice bran extract, rice germ oil, comfrey extract, collagen,
Cowberry extract, Saishin extract, Psychoextract, Saitai extract, Salvia extract, Sabonso extract, Sasa extract, Hawthorn extract, Sansho extract, Shiitake extract, Jio extract, Shikon extract, Perilla extract, Shinanoki extract, Shimotsukeiso extract, Peony extract, Shobu root extract , Birch extract, horsetail extract, vegetative extract, hawthorn extract,
Western elderberry extract, Achillea millefolium extract, Common mint extract, Sage extract, Genus mallow extract, Senkyu extract, Assembly extract, Soybean extract, Tissou extract, Thyme extract, Tea extract, Clove extract, Chigaya extract, Chimpanzee extract, Touki extract, Calendula extract, Tonin extract , Spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, nobara extract, hibiscus extract, bakkumondou extract, parsley extract, honey, hamamelis extract, Parietaria extract, chickpea extract, bisabolol, loquat extract, coltsfoot extract , Fukinotou extract, kukuroyou extract, butcher bloom extract, grape extract, propolis, loofah extract, safflower Vinegar, peppermint extract, lime extract, button extract, hops extract, pine extract, horse chestnut extract, skunk cabbage extract, Sapindus extract, Melissa extract, peach, cornflower extract, eucalyptus extract, saxifrage extract, Yuzuekisu,
Yokuinin extract, mugwort extract, lavender extract,
Examples include apple extract, lettuce extract, lemon extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract and the like. In addition, lemon peel, seaweed, cypress, hiba, rice bran, shrub, ginger, licorice, chimpanzee, spruce, cypress, carrot, peppermint, cauliflower, scallop, mugwort, dokudami, momonoha, chamomile, aloe, jasmine, rosehip , Lavender, guava, orgon,
Pulverized materials such as wolfberry, reishi, elderberry, ashitaba, ukogi and burdock may be used.

Also, biopolymers such as deoxyribonucleic acid, mucopolysaccharides, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, sarcosine,
Amino acid derivatives such as N-methyl-L-serine, moisturizing components such as sodium lactate, urea, sodium pyrrolidone carboxylate, betaine, whey, oily components such as sphingolipids, ceramides, cholesterol, cholesterol derivatives, phospholipids, and ε-aminocapron Acids, glycyrrhizic acid, β-glycyrrhetinic acid, anti-inflammatory agents such as lysozyme chloride, guaiazulene, hydrocortisone, vitamins A, B2, B6, C, D, E, ascorbic acid glucoside, calcium pantothenate, biotin, nicotinamide, vitamin Vitamins such as C ester, active ingredients such as allantoin, diisopropylamine dichloroacetic acid, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, 4-aminomethylcyclohexanecarboxylic acid, tocopherol, carotenoid, Antioxidants such as labonoids, tannins, lignans, saponins; cell activators such as α-hydroxy acids and β-hydroxy acids; blood circulation promoters such as γ-oryzanol and vitamin E derivatives; wound healing agents such as retinol and retinol derivatives , Hinokitiol, camphor,
l-menthol and the like. Furthermore, examples of the enzyme include a protease and a lipase.

The mixing ratio of these physiologically active components to the bath composition depends on the concentration at which the active component exerts its effect. However, in consideration of the extract or the like, it is generally 0.1% based on 100 parts by mass of the cosmetic. It is preferably from 0.5 to 90 parts by mass, more preferably from 0.1 to 50 parts by mass. In addition, it is preferable to mix | blend 1 type or 2 or more types of biologically active components in combination.

In the bath composition of the present invention, in addition to the above-mentioned components, various components usually used in bath compositions can be used in combination. For example, inorganic salts, inorganic acids, organic acids, fats and oils, polyhydric alcohols, fragrances and the like as shown below are exemplified.

1) Inorganic salts sodium chloride, sodium hydrogen carbonate, sodium carbonate, boric acid, borax, sodium sulfate, sodium sulfide, potassium sulfide, sodium nitrate, calcium nitrate,
Ammonium sulfate, sodium thiosulfate, calcium hydrogen phosphate, potassium chloride, ammonium chloride, sodium phosphate, sodium hyposulfite, calcium thiosulfate,
Sulfur, sodium sesquicarbonate, magnesium sulfate, etc.

2) Inorganic acids Silicic anhydride, metasilicic acid, boric acid and the like.

3) Organic acids Benzoic acid, fumaric acid, salicylic acid and the like.

4) Fats and oils Olive oil, soybean oil, almond oil, castor oil, coconut oil, palm oil, turtle oil, nuka oil, jojoba oil, mink oil, egg yolk oil, squalane, avocado oil, lanolin, liquid paraffin, white Vaseline and the like.

5) Polyhydric alcohols Glycerin, diglycerin, propylene glycol, dipropylene glycol, triethylene glycol, sorbitol, polyethylene glycol, 1,3-butylene glycol, raffinose, maltitol, trehalose and the like.

6) Flavors Lavender oil, jasmine oil, rose oil, lemon oil, orange oil, thyme oil, shobu oil, fennel oil, cedar oil, hiba oil, hinoki oil, rose oil, eucalyptus oil, peppermint oil, spearmint Oil, geraniol, tangerine oil,
Natural and synthetic flavors such as spruce and citronellol.

Further, the bath agent composition of the present invention may further comprise, if necessary, a surfactant, a pharmaceutical, a quasi-drug, a tar dye for cosmetics, etc. Can be blended.

As the dosage form of the bath composition of the present invention, conventionally known dosage forms such as solid, powder, liquid, emulsion, and gel can be used.

[0022]

The present invention will be described in detail below with reference to examples and comparative examples. The method for evaluating the basic performance of the cassis extract and evaluating various properties of the bath agent compositions obtained in Examples and Comparative Examples are described below.

The bathing was evaluated by 10 panelists.
The feeling during bathing, the feeling after bathing, and the condition of the skin after continuous use for one month were evaluated. About 200 l of hot water at 40 ° C. was put into the bath, and 30 g of each of the bath compositions having the compositions of Example 1 and Comparative Example 1 described below were charged, and the bath was bathed for 10 minutes. Each of the evaluation items was evaluated on a 5-point scale, with very good 5 points, good 4 points, normal 3 points, and no change 2
The score of the point and one bad point were entered, and the average was taken. Therefore, the higher the score, the higher the evaluation.

(A) Measurement of Maillard Reaction Inhibitory Effect (Part 1) Preparation of Sample Cassis (dried black currant) was added to 10 times the volume of 50% by volume.
After being immersed in a 1,3-butylene glycol aqueous solution for one week, the sample was sterilized by filtration to obtain a sample. In addition, the evaporation residue was 3.9 mass%. Measurement of Maillard reaction inhibitory activity 100 mM sodium hydrogen phosphate 250
Add 50 μl of 2 M glucose, 100 μl of 4 mg / ml bovine serum albumin, and 50 μl of water.
The reaction was performed for 0 hours. After completion of the reaction, the mixture is cooled at 4 ° C. and stirred, and then 100 μl is placed in a container, and 10 μl of a trichloroacetic acid solution is added thereto. After stirring, 4 ° C, 15000 rpm, 4
The mixture was centrifuged under cooling under the conditions of minutes, and the supernatant was removed by suction, and dissolved in 400 μl of an alkaline phosphate buffer. 200 μl was transferred to a 96-well white plate for fluorescence measurement, and the fluorescence was measured at a fluorescence plate reader excitation wavelength of 360 nm and a fluorescence wavelength of 460 nm. Also, measure the absorption rate of the fluorescence of the sample itself,
The value was corrected to determine the Maillard reaction inhibition rate. The inhibition rate is calculated as 100 − [((sample−blank) / (positive control blank)) × 100] −correction value. Measurement results Table 1 shows the results. This sample showed good Maillard reaction inhibitory activity.

(Table 1) Sample Maillard reaction inhibition rate -------------------------------------- -------------------- Blank 100 Positive control 0 Amiguanidine (1 mM, comparative sample) 58 samples (test concentration 10% by mass) 67 samples (test concentration 5 Mass%) 48

(B) Measurement of Maillard Reaction Inhibitory Effect (Part 2) Measurement of Pentosidine Production Inhibition Activity, One of the Final Products of Maillard Reaction Preparation of Samples
After being immersed in an aqueous ethanol solution for one week, the mixture was filtered (evaporation residue: 3.6% by mass) and treated with the same amount of activated carbon as the evaporation residue. Measurement of Pentosidine Production Inhibitory Activity To 50 μl of the sample solution, 90 μl each of 500 mM ribose, 500 mM lysine, 500 mM arginine, 100 mM sodium hydrogen phosphate (pH 7.4) and purified water was added.
It was kept at 0 ° C. for 24 hours. Then, 400 μl of purified water was added to 100 μl of the reaction solvent, and the activity of inhibiting the formation of pentosidine was measured by high performance liquid chromatography. In addition, a 50 volume% ethanol aqueous solution was used as a positive control. Measurement results Table 2 shows the results. This sample exhibited a very good pentosidine production inhibitory effect.

(Table 2) Sample Pentosidine production inhibition rate -------------------------------------- ----------------------- Positive control 0 Amiguanidine (1 mM, comparative sample) 29 samples (test concentration 10% by mass) 95 samples (test concentration) (5% by mass) 84 Sample (test concentration 1% by mass) 49

(C) Histamine release inhibitory effect (Histamine release inhibitory effect was measured using a sample prepared by measuring the Maillard reaction inhibitory effect according to the article of Kubo et al. (Pharmaceutical Magazine, 110, 1, 1990). Measurement result The histamine release inhibition rate of this sample was 4.5%,
It exhibited a weak histamine release inhibitory effect.

(D) Inhibitory effect on melanin biosynthesis The effect of cultured B16 mouse melanoma cells on melanin production was examined. (Whitening effect) Preparation of sample Cassis (dried black currant) is 50 times the volume of 10 times
After immersing in an aqueous ethanol solution for one week, the sample was filtered to prepare a sample. (Evaporation residue: 3.6% by mass) Measurement of melanin biosynthesis inhibitory effect A test was carried out based on a conventional method. As a control, a 50% by volume aqueous ethanol solution and arbutin were used, and the test concentration was 25 ppm in terms of solid content. The measurement used the absorbance of 420 nm. Measurement results Table 3 shows the results. This sample showed a weak whitening effect. No cell growth inhibitory effect of this sample at the test concentration was observed.

(Table 3) Sample melanin amount ---------------------------------------- ----------------------- 50 volume% ethanol aqueous solution 0.18 This sample 0.14 Arbutin 0.11

(E) Superoxide anion radical inhibitory effect The inhibitory effect of a superoxide anion radical (a kind of active oxygen) generated in a xanthine-xanthine oxidase system was examined. Sample The same sample as that prepared in the measurement of the melanin biosynthesis inhibitory effect was used. Measurement of Superoxide Anion Radical Inhibition Effect The inhibition ratio was measured from the absorbance (OD) at 560 nm of the reaction solution according to a conventional method (NBT method). The following equation was used as a calculation method of the suppression rate. As a control, a sample using a solvent instead of the sample was used. Reduction inhibition rate (%) = (1− (OD value of sample−OD value of blank (sample)) / (OD value of sample−OD value of blank (control)) )) × 100 Measurement Results The superoxide anion radical suppression rate of this sample was 75%, indicating a high suppression effect.

(F) Lipid Peroxide Production Inhibition Effect
It was measured by the BA method. Sample The same sample as that prepared in the measurement of the melanin biosynthesis inhibitory effect was used. Measurement of Lipid Peroxide Production Inhibition Effect 4.9 ml of a 0.8% sodium lauryl sulfate solution in which 0.1% linolenic acid is dissolved is placed in a 9 ml container, 0.1 ml of the sample solution is added, and after stirring, ultraviolet light is irradiated for 1 hour. Irradiated. (The irradiation conditions were FL20SE lamp manufactured by Toshiba and F
The L20SBL lamp was irradiated at a distance of 15 cm. 1) 1 ml of this solution was placed in a centrifuge tube containing 0.02 ml of 4.5% BHT, 1 ml of 0.67% thiobarbituric acid / 15% acetic acid aqueous solution was added, and the mixture was heated at 95 ° C. for 1 hour. 15 after cooling
% Methyl alcohol-containing n-butyl alcohol solution 4m
After shaking well, the mixture was centrifuged at 2000 rpm, and the absorbance at 532 nm of the n-butyl alcohol layer was measured to determine the amount of lipid peroxide. Further, a sample not irradiated with ultraviolet rays was prepared, and a difference from the sample irradiated with ultraviolet rays was defined as a lipid peroxide production amount. The lipid peroxide production inhibition rate was calculated from the ratio to the amount of lipid peroxide produced when the sample was added, with the amount of lipid peroxide produced when only the solvent was added instead of the sample taken as 100. Measurement Results The lipid peroxide production inhibition of this sample was 27%, indicating a slightly weaker inhibitory effect.

From the above results, it can be concluded that the water-soluble cassis extract has excellent performance in inhibiting the Maillard reaction, inhibiting melanin production, anti-inflammatory effect, inhibiting active oxygen, and inhibiting lipid peroxide production. I understand.

Examples 1 and 2 and Comparative Examples 1 and 2 Bath compositions having the compositions shown in Table 4 were prepared. The production method followed the method of the usual bath composition. The unit of the compounding amount in the table is% by mass. As the water-soluble cassis extract, a sample used for measuring the Maillard reaction inhibitory effect was used, which was further spray-dried using a spray dryer.

(Table 4) Composition Example 1 Example 2 Comparative Example 1 Comparative Example 2 ----------------------------------- Dry sodium sulfate 40 40 40 40 Sodium bicarbonate 40 40 40 40 Chloride Sodium 5.55 5 dextrin Remaining Remaining Remaining Remaining Remaining Water-soluble cassis extract 11--Enzyme (protease)-11-Red algae extract-0.7 0.7-PEG6000 0.3 0.3 0.3 0.3 Perfume 0.7 0.7 0.7 0.7 Dye trace trace trace trace trace meter 100 100 100 100

Table 5 shows the evaluation results of each of the examples and comparative examples.

(Table 5) Evaluation Items Example 1 Example 2 Comparative Example 1 Comparative Example 2 ------------------------------------- Feel to the skin while taking a bath 4.3 4.4 3.0 2.7 Moist skin 4.2 4.7 2.7 2.3 Skin tension 3.9 4.4 2.8 2.1 Skin texture 4.0 4.4 3.2 2 4.3 Warm well 4.5 4.7 2.5 1.8 Smooth skin 4.3 4.6 2.3 2.1

From the results shown in Table 5, it can be seen that the examples of the present invention have excellent performance in improving the condition of the skin such that the skin is moist and the skin feels smoother than the comparative example. .

[0039]

As described above, the present invention provides a water-soluble cassis extract which is a natural ingredient and has excellent Maillard reaction inhibitory effect, whitening effect, anti-inflammatory effect, active oxygen inhibitory effect, and lipid peroxide production inhibitory effect. By inactivating lipid peroxide in the skin, improving inflammation due to external stress,
It is apparent that the present invention provides a bath composition which imparts moist feeling and smoothness to skin, improves skin aging such as skin tension and texture, and has an excellent body warming effect.

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Claims (1)

[Claims] 1. A bath composition containing a water-soluble cassis extract (black currant seed oil).