JP2002193825A - Liquid composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a solubilized liquid composition stably containing a ginsenoside compound also with the passage of time. SOLUTION: This solubilized liquid composition stably containing the ginsenoside compound originated from ginseng, comprises the ginsenoside compound, a polyglycerol fatty acid ester, a polyoxyethylene-based nonionic surfactant, and an oil component.

Description

DETAILED DESCRIPTION OF THE INVENTION

TECHNICAL FIELD The present invention relates to a solubilized liquid composition in which ginsenosides, which are glycosides in carrots, are stably mixed.

2. Description of the Related Art Ginsenosides exert various pharmacological actions by themselves or by interaction with other components.
Therefore, it is often blended in liquids for nutritional tonicity, recovery from fatigue, and the like. However, such ginsenosides have a problem that they are very easily decomposed in an aqueous solution, particularly in an acidic region. Therefore, a method for stabilizing ginsenosides in a carrot even in an aqueous solution has been desired.

SUMMARY OF THE INVENTION An object of the present invention is to provide a solubilized liquid composition containing ginsenosides stably over time.

Investigations for stabilizing ginsenosides have been repeated. When a polyglycerin fatty acid ester is added to a liquid composition containing ginsenosides, the ginsenosides are dissolved. However, the solubility of polyglycerin fatty acid esters decreases when stored at low temperatures,
Precipitates and floats easily occur. Therefore, it is not preferable to mix the polyglycerin fatty acid ester alone in the solubilized liquid composition. Therefore, by blending a polyoxyethylene-based nonionic surfactant and an oil component in a solubilized liquid composition containing ginsenosides and polyglycerin fatty acid ester, without impairing the appearance,
It has been found that the components of ginsenosides can be prevented from lowering and can be stabilized. That is, the present invention is a ginsenoside-containing solubilized liquid composition containing a polyglycerin fatty acid ester, a polyoxyethylene-based nonionic surfactant, and an oil component. The ginsenosides used in the present invention are present in carrots and carrot extracts, and in the present invention, they can be used in the form of carrot dry powder, extracted extract and the like. Ginsenosides may be those synthesized by organic synthesis or biotechnology, or may be used as they are. The amount of ginsenosides in the present invention in the liquid composition is 1.0 × 10 ^{−4 to} 10 w / v%. Polyglycerin fatty acid ester used in the present invention is decaglycerin monomyristate, hexaglycerin monomyristate, decaglycerin monolaurate, hexaglycerin monolaurate, decaglycerin monostearate, hexaglycerin monostearate ,
Preferred are decaglycene monocaprylate, decaglycerin monooleate, hexaglycerin monooleate, decaglycerin monolinolenate and the like, and one or more of these may be blended. Among them, decaglycerin monomyristate, decaglycerin monostearate, and decaglycerin monolaurate are particularly preferred. For example, Decaglyn 1- made by Nikko Chemicals Co., Ltd.
L, Decaglyn 1-M, Decaglyn 1-S, Decaglyn 1-50VS, Q-14S manufactured by Taiyo Kagaku Co., Ltd. and Sakamoto Chemical ML-750. The amount of the polyglycerin fatty acid ester is 1 to 1000 parts by weight based on 1 part by weight of ginsenosides. Examples of the polyoxyethylene-based nonionic surfactant used in the present invention include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester,
And polyoxyethylene glycerin fatty acid esters. The amount of the polyoxyethylene surfactant is 1 / part by weight of the polyglycerin fatty acid ester.
6 to 1 part by weight. Examples of the oil component used in the present invention include vitamin E and its derivatives, vitamin A, vitamin D, vitamin K, γ-oryzanol, and soybean oil, medium-chain fatty acid triglycerides, and triglycerin fatty acid esters such as γ-linolenic acid. Is mentioned. Also,
The amount of the oil component is 1 × 10 ^-2 to 1 part by weight based on 1 part by weight of the polyglycerin fatty acid ester. In the present invention, for the purpose of suppressing precipitation derived from a crude drug extract, a polymer substance such as polyvinylpyrrolidone, polyoxyethylene polyoxypropylene glycol, or polyvinyl alcohol can be blended. Among them, polyvinylpyrrolidone, polyoxyethylene polyoxy Propylene glycol is particularly preferred. In the present invention, lactose, sucrose, fructose, glucose,
Sorbitol, maltitol, erythritol, xylitol, trehalose, stevia extract and the like can be blended as a sweetener or energy source. Although the pH of the solubilized liquid composition of the present invention is not particularly limited, the pH of the solubilized liquid composition of the present invention is 2.5 to 7, preferably, in consideration of the preservability and flavor of a beverage. The pH is about 3 to 6. Further, as other components, vitamins, minerals, amino acids and salts thereof, non-oil components, crude drugs and crude drug extracts, royal jelly, caffeine, sodium chondroitin sulfate, etc. may be blended within a range that does not impair the effects of the present invention. it can. Also, if necessary, other known additives, for example, antioxidants, coloring agents, fragrances,
Substances generally used in pharmaceutical technology such as flavoring agents, preservatives, and pH adjusters can be blended, and oral preparations such as syrups and liquids can be prepared by a conventional method. Further, a surfactant other than polyglycerin fatty acid ester and polyoxyethylene-based surfactant may be added as a solubilizing agent within a range that does not impair the effects of the present invention. Also,
A water-soluble polyhydric alcohol such as glycerin or diglycerin may be blended as a solubilizer. Examples of pH adjusters include lactic acid, citric acid, malic acid, succinic acid,
Fumaric acid, tartaric acid, phosphoric acid and salts thereof. These pH adjusters can be used alone or in combination.

According to the present invention, the polyglycerin fatty acid ester suppresses the decomposition of ginsenoside in carrot in the liquid composition, and the polyoxyethylene surfactant and the oil component are formed at a low temperature of the polyglycerin fatty acid ester. Suppress the formation of suspended matter. Therefore, according to the present invention, a solubilized liquid composition containing ginsenosides stably can be provided without impairing the appearance.

Next, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited to these descriptions.

Example 1 Various surfactants, glycerin and soybean oil shown in Table 1 were mixed with 80
After heating and mixing at 80 ° C., the mixture was dissolved in hot water at 80 ° C. To these aqueous solutions, 0.18 w / v% of carrot extract (9.0 × 10 ⁻³ w / v% as ginsenoside Rb1 concentration), 0.3 w / v% of polyvinylpyrrolidone and 1.0 w / v% of citric acid were mixed, and 1M- NaOH
Adjusted the pH to 4.6. These were filled in a glass bottle, and a cap was provided.

Comparative Examples Various surfactants, glycerin and soybean oil shown in Table 1 were
After heating and mixing at 80 ° C., the mixture was dissolved in hot water at 80 ° C. To these aqueous solutions, 0.18 w / v% of carrot extract (9.0 × 10 ⁻³ w / v% as ginsenoside Rb1 concentration), 0.3 w / v% of polyvinylpyrrolidone and 1.0 w / v% of citric acid were mixed, and 1M- NaOH
Adjusted the pH to 4.6. These were filled in a glass bottle and capped, and Comparative Examples 1 to 3 were obtained.

[Table 1]

(Evaluation method) After the liquid compositions of the present invention obtained in Example 1 and Comparative Example were stored in a thermostat at 65 ° C. for 5 days, the content of ginsenoside Rb1 in the liquid compositions was quantified by liquid chromatography. . The results are shown as the residual ratio (%) after 5 days at 65 ° C. with respect to the ginsenoside Rb1 content immediately after preparation. After storage in a thermostat at 5 ° C. for one month, precipitates and suspended matter in the content liquid were visually observed. The degree of precipitation and suspended matter was determined according to the criteria shown in Table 2. Table 3 shows the results of these experiments.

[Table 2]

[Table 3]

According to the present invention, ginsenosides derived from carrots can be prevented from being decomposed even in a liquid composition and the ginsenosides can be stabilized without impairing the appearance.

Example 2 Peony extract 30 mg (120 mg in terms of crude drug) Carrot extract (4.5 mg of ginsenosides) 90 mg (600) Ogi-ryu extract 0.3 mL (300) Licorice extract 50 mg (200) Geo extract 300 mg (300) Touki Ryu extract 0.4 mL (400) Liqueur tincture 1.08 mL (300) Epimedium extract 100 mg (1000) Ginger tincture 0.6 mL (120) Cauliflower extract 0.3 mL (300) Yokuininru extract 0.6 mL (600) Hampit tincture 1.25 mL (250) Bakryou extract 9.6 mg (300) Taisounan extract 70 mg (230) Sanya cryu extract 0.3 mL (300) Toshishi extract 33 mg (300) 0.3 mL (300) Calyx tincture 500 mg (100) Onji extract 15 mg (150) Sanjuryu extract 0.5 mL (500) Muirapuama extract 15 mg (300) Oysteryll extract 0.6 mL (600) Silkworm extract 0.3 mL (300) Psycho-Ryu extract 0.15 mL (150) Gourmet Ryu extract 0.3 mL (300) Eucommia biloba extract 0.3 mL (300) VB1 10 mg VB2 5 mg VB6 5 mg Caffeine 50 mg Taurine 500 mg Polyoxyethylene hydrogenated castor oil 100 mg Ester 100mg Decaglycerin monostearate 100mg Soybean oil 30mg Polyvinylpyrrolidone 300mg Polyoxyethylene Reoxyhydroperylene glycol 300 mg Xylitol 5000 mg Sucrose 5000 mg Stevia extract 5 mg Citric acid proper amount DL-Sodium malate 200 mg Propyl parahydroxybenzoate 3.3 mg Butyl paraoxybenzoate 3.3 mg Sodium benzoate 3 mg Suitable amount of mixed fruit flavor 50 mg Each component was stirred and dissolved in purified water to make the total volume 50 mL, thereby obtaining a stable ginsenoside-containing preparation (pH 4.
5).

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (reference) A61P 1/14 A61P 1/14 43/00 107 43/00 107 F term (reference) 4C076 AA12 AA16 BB01 CC40 DD08E DD30Z DD38 DD43Z DD46 EE16 EE23 FF15 FF16 FF43 GG46 4C088 AB18 AC11 BA08 BA13 CA03 MA03 MA04 MA17 MA52 NA03 ZA66 ZB21 ZC01

Claims (3)

[Claims] 1. A solubilized liquid composition comprising ginsenosides, polyglycerin fatty acid ester, a polyoxyethylene nonionic surfactant and an oil component. 2. The polyoxyethylene-based nonionic surfactant is polyoxyethylene hydrogenated castor oil.
A solubilized liquid composition as described 3. The solubilized liquid composition according to claim 1, wherein polyvinyl pyrrolidone or polyoxyethylene polyoxypropylene glycol is blended.