JP2002193737A - Skin care preparation for external use and skin care composition for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new skin bleaching component having greater effect than ever, and to provide a skin care preparation for external use and a skin care composition for external use each formulated therewith. SOLUTION: This skin care preparation for external use contains as the skin bleaching component an extract from the sea algal body of Kappaphycus alvarezii. The other objective skin care composition for external use contains the above extract and medicinal agent(s) selected from among skin bleaching agent, antioxidant, anti-inflammatory agent and ultraviolet inhibitor.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin containing an extract from seaweed alga bodies belonging to the genus Kappaphycus, and more particularly, to a skin pigment containing the extract as a whitening component. The present invention relates to a skin external preparation having an excellent whitening effect on the skin, for example, by preventing the occurrence of deposition, and a skin external preparation composition further containing a pharmaceutically active ingredient.

[0002]

2. Description of the Related Art Conventionally, skin external preparations such as emulsions, creams, lotions, packs, cleansing agents, dispersions, ointments, and external preparations have been treated with various medicinal effects in order to impart predetermined medicinal effects thereto. Ingredients have been added. For example, whitening agents such as ascorbic acid, glutathione, and hydroquinone are often added to skin external preparations in order to prevent phenomena such as darkening of the skin caused by sunburn, pigmentation, and spots and freckles caused by pigmentation.

[0003] However, these known whitening agents may not have the desired whitening effect due to insufficient whitening effect or deterioration in the preparation.
There has been a demand for improvement and provision of a new and more effective whitening component.

[0004]

SUMMARY OF THE INVENTION The present invention has been made under the above circumstances, and has as its object to provide a new and more effective whitening component.

[0005]

Means for Solving the Problems The present inventors have conducted intensive searches for substances that can be used as whitening ingredients in skin external preparations such as cosmetics. And as a result,
Among the alga belonging to the genus Kappaphycus, the algal extract of a specific species has a high melanin production inhibitory effect, and this extract has a better effect by being combined with other medicinal ingredients. And completed the present invention.

That is, the present invention relates to Kappa ficus (Kappa ficus).
aphycus genus Alberettii (Kappaphycus alvarezi)
It is intended to provide an external preparation for skin containing the extract from the seaweed alga body of i) as a whitening component.

The present invention also relates to the following components (A) and (B): (A) an extract from a seaweed algae of the genus Alberetti, of the genus Kappaficus; (B) a whitening agent, an antioxidant, an anti-inflammatory, The present invention provides a skin external preparation composition containing one or two or more pharmaceutically active agents selected from agents.

[0008]

DETAILED DESCRIPTION OF THE INVENTION The genus Kappaficus is a seaweed that mostly grows in the tropics and belongs to the red algae. The seaweed of the genus Kappaficus used in the present invention belongs to the species of the genus Kappaphycus alvarezii (Kappaphycus alvarezii).

In order to obtain the extract used in the present invention from the above-mentioned seaweed algae, the whole seaweed of the seaweed may be dried and then extracted with an appropriate extraction solvent. The extraction method is not particularly limited. For example, the extraction may be performed at a low temperature or at a temperature from room temperature to a heating temperature using a solvent described below.

As the extraction solvent, for example, water, a hydrophilic organic solvent such as a monohydric alcohol and a polyhydric alcohol can be used. Among these, as the monohydric alcohol, lower alcohols such as methyl alcohol and ethyl alcohol are exemplified.
Examples of the polyhydric alcohol include liquid polyhydric alcohols such as glycerin, propylene glycol, and 1,3-butylene glycol. These can be used alone or in combination of two or more.

The method for extracting the seaweed algae extract used in the present invention is not particularly limited.
It is preferable to extract at a temperature of about 100 ° C. for about 2 to 6 hours. For ethyl alcohol having a water content of 0 to 80% by volume, the temperature is about 20 to 60 ° C. for about 1 hour to 2 weeks. For 1,3-butylene glycol having a water content of 0 to 80% by volume, about 20 to 100 ° C. 1 hour to 2 at the temperature of
It is preferable to extract for about a week. It is more preferable that the obtained extract is subjected to filtration to remove insolubles, aged for about one week and aged, and the insolubles generated again are filtered to obtain an extract substantially free of insolubles. .

An extract of the species of the genus Alberetti of the genus Kappaficus of the present invention (hereinafter referred to as “Kappaficus extract”)
Has a high melanin production inhibitory effect by itself,
It can be used as a whitening component of skin external preparations. In this case, the content of the kappa ficus extract is preferably 0.0005 to 5% by mass (hereinafter simply referred to as “%”) as a dry solid content, and more preferably 0.000%.
01 to 2%. When the content is within this range, the seaweed extract can be stably compounded, and a high whitening effect can be exhibited. When an extract is used, the concentration of the extract is not particularly limited as long as the content of the dry solid content as a solute is within the above range.

The kappa ficus extract (component (A)) of the present invention can be combined with other various pharmaceutically active ingredients and incorporated into an external preparation for skin. This medicinal component is not particularly limited, but is further excellent as a skin external preparation composition by being combined with another medicinal component (component (B)) selected from a whitening agent, an antioxidant, an anti-inflammatory agent, and an ultraviolet inhibitor. Can give a whitening effect.

As the medicinal ingredient which is the component (B),
Examples include a whitening agent, an antioxidant, an anti-inflammatory agent, and an ultraviolet inhibitor, and specific examples thereof include those shown below.

(Whitening agent) Examples of the whitening agent include vitamin C and its derivatives, salts thereof, licorice extract and the like.

(Antioxidant) Examples of the antioxidant include vitamin E and its derivatives and salts thereof.

(Anti-inflammatory agent) Examples of the anti-inflammatory agent include glycyrrhizic acid, glycyrrhetinic acid, derivatives thereof, and salts thereof.

(Ultraviolet inhibitor) Examples of the ultraviolet inhibitor include 2-ethylhexyl paramethoxycinnamate, titanium oxide, fine particle titanium oxide, zinc oxide and the like.

The amount of the component (B) in the external preparation for skin combining the component (A) and the component (B) varies depending on the kind of the medicinal agent, but is preferably in the following range. Within this range, a higher whitening effect can be exhibited without affecting the temporal stability of the preparation and the kappa ficus extract (component (A)) in the preparation.

That is, when the whitening agent is compounded as the component (B), the compounding amount is preferably from 0.000001 to 1
0%, and more preferably in the range of 0.0001 to 5%. For example, when the licorice extract is used as a whitening agent as it is as an extract, there is no problem as long as the dry solid content is within this range. Within this range, a skin external preparation exhibiting a more excellent whitening effect and having a good feeling upon use can be obtained.

When the antioxidant is added as the component (B), the amount is preferably 0.0001 to 5%.
%, More preferably 0.001 to 3%. Within this range, a better antioxidant effect can be seen,
In addition, a skin external preparation exhibiting an excellent whitening effect can be obtained.

Further, when the anti-inflammatory agent is compounded as the component (B), the amount is preferably in the range of 0.0001 to 5%, more preferably in the range of 0.01 to 3%. Within this range, an external preparation for skin which exhibits an excellent anti-inflammatory effect and an excellent whitening effect can be obtained.

Further, when the ultraviolet ray inhibitor is blended as the component (B), the amount is preferably 0.00.
The range is from 0.01 to 20%, more preferably from 0.001 to 10%. Within this range, a skin external preparation that exhibits a more excellent ultraviolet ray preventing effect and also has an excellent whitening effect can be obtained.

The component (A) can be added in the above-mentioned amount with respect to the above-mentioned components. In addition, the above-mentioned whitening agents, antioxidants, anti-inflammatory agents, and ultraviolet inhibitors, which are the components (B), can be used alone or in combination of two or more.

The external preparation for skin of the present invention can be prepared according to a conventional method by using a kappa ficus extract (component (A)) which is an essential component alone,
Or combine this with other medicinal ingredients (component (B)),
It can be prepared by blending with various forms of bases known as ordinary skin external preparations.

The form of the external preparation for skin or the external preparation for skin is not particularly limited. For example, cosmetics such as emulsions, creams, lotions, packs, detergents, makeup cosmetics, dispersions, ointments, and external medicines And the like, and the base to be used also depends on the form thereof, and is usually used in an external preparation for skin such as cosmetics and pharmaceuticals, for example, purified water, lower alcohol, polyhydric alcohol, oily component, and powder. , A surfactant, a thickener, a coloring material, a preservative, a humectant, a fragrance and the like can be used.

[0027]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

REFERENCE EXAMPLE 1 Production of an extract from seaweed alga bodies of the genus Alberettii of the genus Kappaficus: 100 mL of purified water was added to 10 g of a dried alga body of the genus Alberettii of the genus Kappaficus, and 95 ° C.
For 2 hours. Next, the insolubles were filtered to obtain a kappa ficus extract. Table 1 shows the dry solid content of the obtained extract.

[0029]

[Table 1]

Reference Example 2 Production of yoquinin extract: 10 g of yoquinin (JP)
100 mL of ethyl alcohol with a water content of 70% by volume
And extracted at room temperature for 3 days. Next, the insolubles were filtered to obtain a yoquinin extract. At this time, the dry solid content of the yokunin extract was 0.8%.

Test Example 1 Inhibition of melanin production and cell viability test by cell culture:
B16 melanoma cultured cells derived from mice were used. 2
An appropriate amount of medium was taken in a 6-well petri dish, B16 melanoma cells were inoculated, and allowed to stand at 37 ° C. in a carbon dioxide concentration of 5%. The next day, the kappa ficus extract obtained in Reference Example 1 was
Final concentrations of 0 (control), 10, 100, 100 respectively
0 μg / mL was added and mixed.

On the fifth day of the culture, the medium was changed, and the same kappa ficus extract was added again. On the next day, the medium was removed, and one petri dish was washed with a phosphate buffer and then collected. The degree of whitening of the cultured B16 melanoma cells was evaluated according to the following criteria.

For comparison, a similar test was carried out using a yoquinin extract which is already known to have a melanin production inhibitory effect.

(Judgment Criteria) <Judgment> <Contents> ++: extremely white with respect to the control. +: Clearly white with respect to the control. ±: slightly white with respect to the control. -: The same black color as the control.

For the remaining one petri dish, the cells were fixed in formalin and then immersed in a 1% crystal violet solution for staining. The viable cell ratio for each sample concentration was measured with a monocerator (Olympus). Table 2 shows the above results.

(Results)

[Table 2]

As is clear from the results in Table 2, the kappa ficus extract has a high melanin production inhibitory activity and
Low toxicity was observed for 16 melanoma cultured cells. Therefore, the skin external preparation of the present invention containing the kappa ficus extract is applied to the skin,
It has an extremely excellent melanin production inhibitory effect and effectively suppresses skin blackening, spots, freckles, etc. due to sunburn.

Example 1 Cream: A cream was prepared according to the formulation shown in Table 3 and the following method. The whitening effect of the obtained cream was examined by the test method described below. The results are also shown in Table 3.

(Prescription and Results)

[Table 3]

(Production method) A. Components (1) to (6) and (9) are mixed and heated to 70 ° C. B. Heat a portion of component (11) and maintain at 70 ° C. C. Add “B.” to “A.” and add components (7), (1)
After mixing the components (8) and (10) dissolved in the remainder of 1), the mixture was cooled to obtain a cream.

(Test method) 2 per test cream
A panel consisting of 15 women aged 7-54 years
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The panel evaluated the whitening effect of the coating according to the following criteria.

(Evaluation Criteria) <Evaluation> <Contents> Effective: The dullness of the skin became less noticeable. Slightly effective: Skin dullness became less noticeable. Ineffective: No change from before use.

As shown in the results in Table 3, the external preparation of the product 1 of the present invention containing the kappa ficus extract prevents and improves the occurrence of "dullness" of the skin by applying them to the skin. It was clear that the skin could be beautiful.

Example 2 Cosmetic lotion: A lotion was prepared according to the following formulation and production method.

(Formulation) Ingredient Mass% (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) 1.2 Sorbitan monolaurate (4 ) Ethyl alcohol 8.0 (5) Kappa ficus extract * 1 1.0 (6) Appropriate amount of preservative (7) Appropriate amount of fragrance (8) Residual amount of purified water * 1: Produced in Reference Example 1.

(Production method) A. Components (3), (4), (6) and (7) are mixed and dissolved. B. Mix and dissolve components (1), (2), (5) and (8). C. "A." and "B." were mixed and made uniform to obtain a lotion.

Example 3 Emulsion: An emulsion was prepared according to the following formulation and production method.

(Formulation) Ingredient Mass% (1) Polyoxyethylene (10EO) 1.0 Sorbitan monostearate (2) Polyoxyethylene (60EO) 0.5 Sorbit tetraoleate (3 ) Glyceryl monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Kappa ficus extract * 1 4.0 (8) Licorice extract * 3 5.0 (9) Preservative 0.1 (10) Carboxyvinyl polymer aqueous solution (1%) 10.0 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Purified water balance ( 14) Appropriate amount of flavor * 1: Produced in Reference Example 1 * 3: Maruzen Pharmaceutical Co., Ltd.

(Preparation method) A. Components (11) to (13) are mixed by heating and maintained at 70 ° C. B. Components (1) to (6) and (9) were mixed by heating.
Keep at ° C. C. Add “A.” to “B.”, mix and emulsify uniformly. D. After cooling “C.”, components (7), (8), (1)
0) and (14) were added and mixed uniformly to obtain an emulsion.

The lotion obtained in Example 2 and Example 3
Each of the emulsions obtained in the above was excellent in stability over time, and was applied to the skin to prevent "dullness" of the skin due to sunburn, spots and freckles, and to give clear and beautiful skin.

Example 4 Ointment: An ointment was prepared according to the following formulation and production method.

(Formulation) Ingredient Mass% (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Kappaficus extract * 1 1.0 (6) Dipotassium glycyrrhizinate * 4 0.5 (7) dl-α-tocopherol acetate * 5 0.2 (8) Remaining purified water * 1: Produced in Reference Example 1 * 4: Maruzen Pharmaceutical * 5: Eisai

(Preparation Method) A. A part of the components (3), (4) and (8) is mixed by heating and kept at 75 ° C. B. Components (1), (2) and (7) are mixed by heating.
Keep at 5 ° C. C. Gradually add "A." to "B." D. While cooling “C.”, components (5) and (6) dissolved in the rest of component (8) were added to obtain an ointment.

The ointment obtained in Example 4 is excellent in stability over time and, when applied to the skin, prevents the skin from dulling, spots and freckles, and gives a clear and beautiful skin. Was.

Example 5 Pack: A pack was prepared according to the following formulation and manufacturing method.

(Formulation) Ingredient) mass% (1) polyvinyl alcohol 20.0 (2) ethyl alcohol 20.0 (3) glycerin 5.0 (4) kaolin 6.0 (5) kappa ficus extract * 1 1.0 (6) Magnesium-L-alkorbyl phosphate * 6 0.1 (7) Preservative 0.2 (8) Fragrance 0.1 (9) Remaining amount of purified water * 1: Produced in Reference Example 1. * 6: Nikko Chemicals Co., Ltd.

(Production Method) A. A part of the components (1), (3), (4) and (9) is mixed, heated to 70 ° C., and stirred. B. Mix components (2) and (7). C. The above “B.” was added to the above “A.”, mixed, cooled, and (6) dissolved in the rest of (5), (8) and (9) was added and uniformly dispersed. Got a pack.

The pack obtained in Example 5 was excellent in stability over time and, when applied to the skin, prevented the skin from becoming dull and blemishes, and gave a beautiful transparent skin.

Example 6 Liquid foundation: A liquid foundation was prepared according to the following formulation and production method.

(Formulation) Ingredient mass% (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Paramethoxycinnamic acid 3.0 -2-Ethylhexyl (6) Glycerin 5.0 (7) Triethanolamine 1.0 (8) Carboxymethylcellulose 0.7 (9) Remaining amount of purified water (10) Titanium oxide 8.0 (11) Fine particle titanium oxide 2 (12) Zinc oxide 5.0 (13) Mica 15.0 (14) Talc 6.0 (15) Color pigment 6.0 (16) Kappa ficus extract * 1 0.01 (17) Yoquinin extract * 2 0.5 (18) Appropriate amount of perfume * 1: Manufactured in Reference Example 1 * 2: Manufactured in Reference Example 2

(Production method) A. Components (1) to (5) are mixed and dissolved. B. Add components (10) to (15) to “A.”, mix uniformly, and keep at 70 ° C. C. Components (6) to (9) are uniformly dissolved and kept at 70 ° C. D. Add “C.” to “B.” and emulsify uniformly. E. After cooling "D.", components (16) to (18) were added to obtain a liquid foundation.

The liquid foundation obtained in Example 6 was excellent in stability over time and, when applied to the skin, prevented blackening of the skin due to sunburn and the like, and spots and freckles.

[0063]

As described above, the kappa ficus extract of the present invention has excellent melanin production inhibitory activity and high safety. Therefore, a skin external preparation and a skin external preparation composition containing the same can exhibit a high inhibitory effect on melanin production and pigmentation, dull skin, darkening of the skin due to sunburn, stains, It is effective for preventing and improving freckles. that's all

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 35/80 A61K 35/80 Z 45/06 45/06 A61P 17/16 A61P 17/16 (72) Invention Akira Inomata 48-18 Sakaemachi, Kita-ku, Tokyo Inside the Kosei Research Division (72) Inventor Masato Izume 5-511 Namiki, Tsuchiura-shi, Ibaraki Chikarin Katakura Inside Tsukuba Research Institute, Inc. (72) Inventor Tajima Michihiro 5551, Namiki, Tsuchiura-shi, Ibaraki Pref., Tsukuba Research Institute, Katakura Chikarin Co., Ltd. (72) Inventor Takahiro Fukuhara 5-511, Namiki, Tsuchiura-shi, Ibaraki Pref. AA082 AA111 AA112 AB032 AB211 AB212 AB241 AB242 AB432 AB442 AC022 AC062 AC072 AC102 AC122 AC242 AC341 AC342 AC422 AC442 AC542 AD092 AD112 AD272 AD512 AD531 AD532 AD641 AD642 AD661 AD662 BB46 CC04 CC05 CC07 CC12 EE12 EE16 4C084 AA19 MA28 MA63 ZA891 4C088 AA14 BA08 MA02 MA28 ZA89

Claims (7)

[Claims] 1. An external preparation for skin containing an extract from a seaweed algae of the genus Kappaphycus alvarezii of the genus Kappaphycus as a whitening component. 2. The extract from seaweed alga bodies of the species Alberettii of the genus Kappaficus is converted to a dry solid content of 0.00.
The external preparation for skin according to claim 1, which contains 0005 to 5% by mass. 3. The following components (A) and (B): (A) an extract from seaweed alga bodies of the genus Alberettii of the genus Kappaficus; (B) selected from whitening agents, antioxidants, anti-inflammatory agents, and ultraviolet inhibitors. An external preparation composition for skin containing one or more of the above-mentioned medicinal agents. 4. The composition for external use on skin according to claim 3, wherein the whitening agent is selected from vitamin C and its derivatives, salts thereof and licorice extract. 5. The composition for external use on skin according to claim 3, wherein the antioxidant is selected from vitamin E and its derivatives and salts thereof. 6. The composition for external use on the skin according to claim 3, wherein the anti-inflammatory agent is selected from glycyrrhizic acid, glycyrrhetinic acid, derivatives thereof, and salts thereof. 7. The composition for external use on the skin according to claim 3, wherein the ultraviolet ray preventing agent is selected from 2-ethylhexyl paramethoxycinnamate, titanium oxide, fine particle titanium oxide, and zinc oxide.