JP2002125619A - Lycopene composition, method of producing the same and use thereof - Google Patents
Lycopene composition, method of producing the same and use thereofInfo
- Publication number
- JP2002125619A JP2002125619A JP2000331960A JP2000331960A JP2002125619A JP 2002125619 A JP2002125619 A JP 2002125619A JP 2000331960 A JP2000331960 A JP 2000331960A JP 2000331960 A JP2000331960 A JP 2000331960A JP 2002125619 A JP2002125619 A JP 2002125619A
- Authority
- JP
- Japan
- Prior art keywords
- lycopene
- ethanol
- composition
- food
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、安全で且つリコペ
ン含有量が９％以上のリコペン組成物、その製造法およ
び用途に関する。さらに詳しくはトマト由来リコペン含
有液を乾燥後、エタノールを用いて洗浄する製造法、並
びに健康食品、食品、食品添加物、医薬品、化粧品又は
動物用飼料への用途に関する。TECHNICAL FIELD The present invention relates to a lycopene composition which is safe and has a lycopene content of 9% or more, a method for producing the same and a use thereof. More specifically, the present invention relates to a production method of drying a tomato-derived lycopene-containing liquid and then washing the liquid with ethanol, and use of the liquid in health foods, foods, food additives, pharmaceuticals, cosmetics, and animal feeds.
【０００２】[0002]
【従来の技術】リコペンは分子式Ｃ40Ｈ56、分子量５３
６．８８の脂溶性天然カロチノイドであり、例えば、ト
マト果実からリコペンを抽出する場合、ヘキサンや酢酸
エチル、ジクロロメタン、石油エーテルなどの有機溶媒
を用いることが多いが（特開平１０−２２６６５４、特
表平１０−５０９５９０、特開２０００−１０３７３
３）、これらの溶媒は安全衛生上、製造工程で使用する
ことは望ましくなく、従って、精製リコペン製剤の食品
分野等への使用が限られていた。また、安全衛生上望ま
しい溶媒のみの使用から製造されたリコペン組成物はリ
コペンとしての含量が低かった。例えば、特開平９−１
８３９１４、特開平１０−３２４８１６や米国特許５，
８７１，５７４の実施例にはトマト処理物からトマト色
素（ペースト状リコペン組成物）を製造する方法が開示
されているが、これらのペースト状リコペン組成物中の
リコペン含量は約０．５〜１．０％である。含有量が低
いために用途や加工特性が限られ、十分には利用されに
くかった。一方、エタノール以外の有機溶媒により精製
したリコペンは、リコペン含量は高いが、残留溶媒の問
題など安全衛生上好ましくない点があり、又、法的な問
題もあり、例えば食品に利用することは制限を受けてい
る。さらに、通常この類の精製リコペンは脂溶性で水に
溶けない性質があるため、水系の健康食品、食品、食品
添加物、医薬品、化粧品、動物用飼料への利用が容易で
なかった。2. Description of the Related Art Lycopene has a molecular formula of C 40 H 56 and a molecular weight of 53.
6.88 is a fat-soluble natural carotenoid. For example, when lycopene is extracted from tomato fruit, an organic solvent such as hexane, ethyl acetate, dichloromethane, or petroleum ether is often used. Hei 10-509590, JP-A-2000-10373
3) In terms of safety and health, it is not desirable to use these solvents in the production process, and thus, the use of the purified lycopene formulation in the food field has been limited. Also, the lycopene composition prepared from the use of only a solvent that is desirable for safety and health had a low content as lycopene. For example, Japanese Patent Laid-Open No. 9-1
83914, JP-A-10-324816 and U.S. Pat.
The examples 871 and 574 disclose a method for producing a tomato pigment (pasty lycopene composition) from a processed tomato product, and the lycopene content in these pasty lycopene compositions is about 0.5-1. 0.0%. Because of its low content, its use and processing characteristics were limited, making it difficult to use it satisfactorily. On the other hand, lycopene purified with an organic solvent other than ethanol has a high lycopene content, but there is a problem in terms of safety and hygiene such as a problem of a residual solvent, and there are also legal problems. Is receiving. Furthermore, since purified lycopene of this type is generally fat-soluble and insoluble in water, it has not been easy to use it in water-based health foods, foods, food additives, pharmaceuticals, cosmetics, and animal feeds.
【０００３】[0003]
【本発明が解決しようとする課題】本発明は、安全衛生
上好ましくない有機溶媒（例えばヘキサンや酢酸エチ
ル、ジクロロメタン、石油エーテル等）を使用すること
なく安全に、水分散性と安定性に良い高純度リコペン組
成物の製造法を提供し、ならびに健康食品、食品、食品
添加物、医薬品、化粧品、動物用飼料への用途を提供し
ようとするものである。DISCLOSURE OF THE INVENTION The present invention has a good water dispersibility and stability without using an organic solvent (for example, hexane, ethyl acetate, dichloromethane, petroleum ether, etc.) which is not preferable for safety and health. An object of the present invention is to provide a method for producing a high-purity lycopene composition, and to provide uses for health foods, foods, food additives, pharmaceuticals, cosmetics, and animal feeds.
【０００４】[0004]
【課題を解決するための手段】本発明者らは従来技術の
欠点を改善するため鋭意研究を重ねた結果、トマト処理
物を従来法（特開平９−１８３９１４、特開平１０−３
２４８１６に記載された手法）により処理して得られた
リコペン含有液（リコペン含有量約０．５〜１．０％）
を、乾燥した後、エタノールを用い洗浄、部分精製し、
溶媒を除去することにより、安全衛生上好ましくない有
機溶媒を使用することなくリコペン含有量を大幅に向上
させることができることを見出し、本発明を完成した。Means for Solving the Problems The inventors of the present invention have conducted intensive studies in order to improve the disadvantages of the prior art, and as a result, the processed tomato products have been obtained by the conventional methods (Japanese Patent Laid-Open Nos. 9-183914 and 10-3).
Lycopene-containing liquid (lycopene content: about 0.5 to 1.0%) obtained by treatment according to the method described in 24816)
Is dried, washed with ethanol, partially purified,
It has been found that by removing the solvent, the content of lycopene can be significantly improved without using an organic solvent that is not preferable for safety and health, and thus completed the present invention.
【０００５】[0005]
【発明の実施の形態】本発明に用いるトマト処理物は、
トマト果実が原料であれば何でもよく、例えば、生のト
マト果実を常法により洗浄後、破砕し、６５℃に加熱
後、０．５ｍｍスクリーンを備えたフィニッシャーで搾
汁して得られるトマトジュース。またはトマトペース
ト。この時、用いるトマトは品種改良によりリコペン含
量が強化されているものがより望ましい。BEST MODE FOR CARRYING OUT THE INVENTION The processed tomato product used in the present invention is
Any material may be used as long as the tomato fruit is a raw material. For example, a tomato juice obtained by washing a fresh tomato fruit by a conventional method, crushing, heating to 65 ° C., and squeezing with a finisher equipped with a 0.5 mm screen. Or tomato paste. At this time, it is more preferable that the lycopene content of the tomato used is enhanced by breeding.
【０００６】本発明に用いるリコペン液は、トマト処理
物をさらに処理してできるリコペン含量が増えたもので
ある。例えば、ペクトリアーゼなどの酵素活性によりト
マト処理物中の植物組織を崩壊させることにより粘度を
低下せしめた後、精密濾過を行い保持液側に得られる液
である。この液はリコペンを０．５〜１．０重量％含有
しているリコペン液である。The lycopene liquid used in the present invention has an increased lycopene content obtained by further processing the processed tomato product. For example, a liquid obtained by reducing the viscosity by disintegrating the plant tissue in the processed tomato product by enzymatic activity such as pectolyase and then performing microfiltration on the retentate side. This liquid is a lycopene liquid containing 0.5 to 1.0% by weight of lycopene.
【０００７】本発明に用いる乾燥方法は、リコペン液を
乾燥できれば何でも良く、例えば、ロータリーエバポレ
ータによる乾燥法、噴霧乾燥、凍結乾燥等の常法の他、
マイクロ波を照射した乾燥方法、遠赤外線による加熱乾
燥方法も用いることができる。しかし、乾燥する時の温
度や時間、乾燥粉末の形状がリコペンに与える影響、乾
燥粉末の形状そのもの、色調、安定性などの観点から、
マイクロ波照射乾燥法と遠赤外線加熱乾燥法がより望ま
しい。The drying method used in the present invention is not particularly limited as long as the lycopene liquid can be dried. For example, a drying method using a rotary evaporator, a spray drying method, a freeze drying method, etc.
A drying method using microwave irradiation and a heating drying method using far infrared rays can also be used. However, from the viewpoint of the temperature and time of drying, the effect of the shape of the dry powder on lycopene, the shape of the dry powder itself, color tone, stability, etc.
Microwave irradiation drying and far infrared heating drying are more desirable.
【０００８】本発明に於けるエタノール洗浄、部分精製
で用いるエタノールの濃度は、１０〜１００容量％の範
囲内で使用することができ、特に５０〜９０容量％がリ
コペン純度を向上させる点から望ましい。エタノール使
用量は、乾燥粉末重量に対して０．５倍以上用いて行う
が、特に２〜５０倍の範囲がリコペン純度向上とコスト
面から望ましい。洗浄温度は、エタノール溶液が凍結ま
たは沸騰しない範囲であれば何度でも良い。洗浄時間
は、洗浄温度等の条件によっても異なるが、総じて１秒
〜２４時間の範囲内で行う。洗浄方法としては、エタノ
ールを入れたタンク内にリコペン粉末を投入し攪拌する
バッチ式で洗浄してもよく、カラム内又はフィルター上
にセットしたリコペン粉末にエタノール溶液を連続的に
投入、接触させ通過させる洗浄法を用いてもよく、エタ
ノール溶液中でリコペン粉末を瞬間的に通過させる洗浄
法を用いても良い。洗浄回数は、必要に応じ１回から何
回でも行うことができるが、１０回以上にわたりエタノ
ール溶液にて洗浄を繰返すと逆にリコペン含量が低下す
ることがあるため、望ましくは１〜３回がリコペン純度
向上の点から良い。[0008] The concentration of ethanol used in the washing and partial purification of ethanol in the present invention can be used within a range of 10 to 100% by volume, and particularly preferably 50 to 90% by volume from the viewpoint of improving the lycopene purity. . The amount of ethanol used is 0.5 times or more based on the weight of the dry powder, and a range of 2 to 50 times is particularly desirable from the viewpoint of improving lycopene purity and cost. The washing temperature may be any number as long as the ethanol solution does not freeze or boil. The cleaning time varies depending on conditions such as the cleaning temperature, but is generally in the range of 1 second to 24 hours. As a washing method, lycopene powder may be put into a tank containing ethanol and washed by a batch method in which stirring is performed, and an ethanol solution is continuously put into, contacted with, and passed through a lycopene powder set in a column or on a filter. Or a washing method in which lycopene powder is allowed to pass instantaneously in an ethanol solution. The number of washings can be as many as one to as many times as necessary. However, if washing with an ethanol solution is repeated more than ten times, the content of lycopene may be reduced. Good for improving lycopene purity.
【０００９】洗浄後のリコペン組成物は残留するエタノ
ールおよび水分を除去する。その方法として、自然乾
燥、減圧乾燥、乾燥剤による方法などが挙げられるがそ
れらを組合わせても良い。その結果得られたリコペン組
成物は必要に応じ破砕することができる。用途別に微粉
末状から粗い粉末状までに調製することができる。得ら
れた粉末状の高含有リコペン組成物は、劣化を防ぎ、流
通させる目的として遮光密封包装し、脱酸素剤を同封す
ることもできる。The lycopene composition after washing removes residual ethanol and moisture. Examples of the method include natural drying, drying under reduced pressure, and a method using a desiccant, and these may be combined. The resulting lycopene composition can be crushed as needed. It can be prepared from fine powder to coarse powder for each application. The obtained powdery high-content lycopene composition may be sealed in a light-tight seal for the purpose of preventing deterioration and distributing, and may be enclosed with an oxygen scavenger.
【００１０】本発明で得られたリコペン組成物の使用形
態はカプセル状、タブレット状、直接添加物としてなど
が挙げられる。また、このリコペン組成物は良好な水溶
性を有しており（リコペン組成物１ｇは１０ｍｌの水に
分散する）、水と混合して得た水分散液は健康食品、食
品、食品添加物、医薬品、化粧品、又は動物用飼料に使
用することができる。The use form of the lycopene composition obtained in the present invention includes a capsule form, a tablet form and a direct additive. The lycopene composition has good water solubility (1 g of the lycopene composition is dispersed in 10 ml of water), and an aqueous dispersion obtained by mixing with water is used for health foods, foods, food additives, It can be used for pharmaceuticals, cosmetics, or animal feed.
【００１１】[0011]
【実施例】以下、実施例により本発明を更に具体的に説
明する。 実施例１（リコペン組成物及びその製造） （１）リコペン液の調製：特開平１０−３２４８１６に
記載された手法に準じ、リコペン１．８重量％のリコペ
ン液を調製した。すなわち、トマトペーストを原料とし
た時のリコペン液の製造を示す。トマトペースト２３０
ｋｇに水を加えて希釈し、Ｂｒｉｘを７に調整した。こ
の希釈液１１５０ｋｇを乳化機（荏原製作所社製、マイ
ルダー、ＭＤＮ３０３Ｖ−Ｃ型）を用い、１０００ｒｐ
ｍで破砕処理を行った。続いて、遠心分離機（ウエスト
ファリア社製、セパレーター、ＳＢ７−０６−１７６
型）で６０００ｒｐｍ、４分間の条件で脱パルプ処理を
行った。次いで、パルプの断片を完全に除去するため、
遠心上澄液を３００メッシュ節に通した。この液中のリ
コペン含量は０．０１重量％であった。The present invention will be described more specifically with reference to the following examples. Example 1 (Lycopene composition and production thereof) (1) Preparation of lycopene solution: A 1.8% by weight lycopene lycopene solution was prepared according to the method described in JP-A-10-324816. That is, production of lycopene liquid using tomato paste as a raw material is shown. Tomato paste 230
The kg was diluted by adding water to adjust Brix to 7. Using an emulsifying machine (manufactured by Ebara Seisakusho Co., Ltd., Milder, MDN303V-C type), 1150 kg of this diluted solution was subjected to 1000 rpm.
The crushing process was performed at m. Subsequently, a centrifuge (Separator, SB7-06-176, manufactured by Westphalia Co., Ltd.)
(Pulverized mold) at 6000 rpm for 4 minutes. Then, to completely remove the pulp fragments,
The centrifuged supernatant was passed through a 300 mesh node. The lycopene content in this liquid was 0.01% by weight.
【００１２】この上澄液を０．２μｍの排除径の精密濾
過機（Ｃｅｒａｍｅｍ社製、ＳＡ−０２００型、膜面積
１１．５ｍ2）に供給し、温度５０℃、圧力４ｋｇ／ｃ
ｍ2の条件で処理して透過液部を分離し、リコペンを含
有する濃縮液を装置保持液部に非透過物として濃縮し
た。この濃縮液中のリコペン含量は０．２５重量％であ
った。The supernatant is supplied to a 0.2 μm-exclusion-diameter microfiltration machine (SA-0200, manufactured by Ceramem, membrane area 11.5 m 2 ), and the temperature is 50 ° C., the pressure is 4 kg / c.
The mixture was treated under the conditions of m 2 to separate the permeate, and the concentrated liquid containing lycopene was concentrated as a non-permeate in the liquid retained in the device. The lycopene content in this concentrate was 0.25% by weight.
【００１３】この液を再度０．２μｍの排除径の精密濾
過機（日本ガイシ社製、ＮＧＫ−Ｃｅｆｉｌｔ．０．３
５ｍ2）で、５０℃、入口圧力２ｋｇ／ｃｍ2の条件で処
理し、保持液側にリコペンを１．０重量％含有するリコ
ペン液を得た。このリコペン液を採取し、これに食品添
加用エタノールを最終濃度７５％になるように常温で添
加混合し、３０分攪拌してアルコール洗浄した後、５０
００ｒｐｍ、１５分の遠心分離条件で沈降物をエタノー
ル部から分離した。得られた沈降物に活性炭処理水を添
加して明赤色を呈した色調の良い、リコペン１．８重量
％を含有するリコペン液（トマト色素液：ペースト状）
１０ｋｇを得た。本リコペン液を対照品１とした。This solution was again filtered with a 0.2 μm exclusion diameter microfilter (NGK-Cefilt. 0.3, manufactured by NGK Insulators, Ltd.).
5 m 2 ) at 50 ° C. under an inlet pressure of 2 kg / cm 2 to obtain a lycopene solution containing 1.0% by weight of lycopene on the retentate side. This lycopene solution was collected, and ethanol for food addition was added and mixed at room temperature to a final concentration of 75%, and the mixture was stirred for 30 minutes and washed with alcohol.
The precipitate was separated from the ethanol part under the conditions of centrifugation at 00 rpm for 15 minutes. A lycopene solution containing 1.8% by weight of lycopene (tomato pigment solution: paste-like) having a bright red color by adding activated carbon treated water to the obtained precipitate and having a good color tone.
10 kg were obtained. This lycopene liquid was used as a control product 1.
【００１４】（２）リコペン液の乾燥：リコペン液５４
０ｇに遠赤外線を照射し、１３５分間、減圧下（７〜１
３ｔｏｒｒ）で乾燥したところ８８ｇのリコペン粉末を
得た。乾燥時の温度は０〜１５℃に制御した。得られた
リコペン粉末は、９．７重量％であった。(2) Drying of lycopene liquid: lycopene liquid 54
Irradiate 0 g with far-infrared ray and reduce the pressure for 135 minutes (7-1-1).
Drying at 3 torr gave 88 g of lycopene powder. The temperature during drying was controlled at 0 to 15 ° C. The obtained lycopene powder was 9.7% by weight.
【００１５】（３）エタノール洗浄による部分精製なら
びにリコペン組成物の製造：次にこのリコペン粉末１０
ｇ（リコペン含量９．７重量％）に８０容量％エタノー
ル溶液２５０ｍｌ加え、超音波をかけて懸濁させた。こ
れを直ちにメンブランフィルターで濾過し、真空ポンプ
にて乾燥させ、粉砕粉末化し、リコペン組成物８．０ｇ
を得た。そのリコペン含量は１２．７重量％であった。
本リコペン組成物は本発明品である。なお、リコペン含
量の測定は、上記いずれの場合も、石油エーテル中の吸
光度法（４７２ｎｍ、分子吸光係数３４５０、Ｍｅｒｃ
ｋ Ｉｎｄｅｘ記載）によって行った。(3) Partial purification by washing with ethanol and production of a lycopene composition:
g (lycopene content: 9.7% by weight) was added to 250 ml of an 80% by volume ethanol solution, and suspended by applying ultrasonic waves. This was immediately filtered through a membrane filter, dried with a vacuum pump, pulverized and powdered, and 8.0 g of a lycopene composition.
Got. Its lycopene content was 12.7% by weight.
The present lycopene composition is the product of the present invention. In all cases, the lycopene content was measured by the absorbance method in petroleum ether (472 nm, molecular extinction coefficient 3450, Merc
k Index).
【００１６】対照品１について噴霧乾燥したものを調製
し、対照品２とした。以上得られた結果をまとめて、表
１とした。この表１から判るように、本発明品は従来法
で得られるものよりも、リコペン含有量が向上している
ことが判る。The control product 1 was prepared by spray-drying and used as a control product 2. Table 1 summarizes the results obtained above. As can be seen from Table 1, the lycopene content of the product of the present invention is higher than that obtained by the conventional method.
【００１７】[0017]
【表１】 [Table 1]
【００１８】実験例１（リコペン液の乾燥法の比較） （１）噴霧乾燥法による乾燥： 実施例１で調製したリ
コペン液５００ｇを常法により噴霧乾燥したところ６１
ｇのリコペン粉末を得た。 （２）凍結乾燥法による乾燥：リコペン液５００ｇを常
法により凍結乾燥したところ７４ｇのリコペン粉末を得
た。Experimental Example 1 (Comparison of Lycopene Liquid Drying Methods) (1) Drying by Spray Drying Method: 500 g of the lycopene liquid prepared in Example 1 was spray-dried by a conventional method.
g of lycopene powder was obtained. (2) Drying by freeze-drying method: When 500 g of lycopene solution was freeze-dried by a conventional method, 74 g of lycopene powder was obtained.
【００１９】（３）遠赤外線加熱法による乾燥：リコペ
ン液５００ｇに遠赤外線を照射し、１３５分間、減圧下
（７〜１３ｔｏｒｒ）乾燥温度０〜１５℃で乾燥したと
ころ８１ｇのリコペン粉末を得た。 （４）マイクロ波照射法による乾燥：リコペン液５００
ｇにマイクロ波（０．３ｋｗ）を照射し、６８分間、減
圧下（７〜１３ｔｏｒｒ）温度７〜１５℃で乾燥したと
ころリコペン粉末８２ｇを得た。(3) Drying by far-infrared heating method: 500 g of the lycopene liquid was irradiated with far-infrared rays, and dried under a reduced pressure (7-13 torr) at a drying temperature of 0 to 15 ° C. for 135 minutes to obtain 81 g of lycopene powder. . (4) Drying by microwave irradiation method: Lycopene liquid 500
g was irradiated with microwaves (0.3 kw) and dried at a temperature of 7 to 15 ° C. under reduced pressure (7-13 torr) for 68 minutes to obtain 82 g of lycopene powder.
【００２０】以上得られた４種のリコペン粉末中のリコ
ペン含量を実施例１記載の方法で測定し,結果をまと
め、表２に示した。この表２から、リコペン含量の点か
ら、遠赤外線加熱乾燥法とマイクロ波照射乾燥法が、噴
霧乾燥法や凍結乾燥法よりも乾燥法として望ましいこと
が判る。The content of lycopene in the four lycopene powders obtained as described above was measured by the method described in Example 1, and the results are summarized in Table 2. From Table 2, it can be seen that the far-infrared heat drying method and the microwave irradiation drying method are more preferable than the spray drying method and the freeze drying method in terms of the content of lycopene.
【００２１】[0021]
【表２】 [Table 2]
【００２２】実験例２（リコペン粉末の保存安定性試
験） 実験例１で製造したリコペン粉末の保存安定性試験を下
記の４条件下において実施した。 遮光、密封、４０℃、６ヶ月間、脱酸素剤封入 遮光、密封、４０℃、６ヶ月間 非遮光、密封、４０℃、６ヶ月間 遮光、大量の空気と共に密封、４０℃、６ヶ月間 その結果は、表３に示しとおり、保存条件の場合、リ
コペンは全く安定であったが、、、の場合では、
リコペン含量が低下し粉末の品質が劣化した。この結果
より、本発明によるリコペン組成物の保存には遮光密封
の上、脱酸素剤の同封が望ましいことが判る。Experimental Example 2 (Storage stability test of lycopene powder) A storage stability test of the lycopene powder produced in Experimental Example 1 was performed under the following four conditions. Shading, sealed, 40 ° C, 6 months, encapsulating oxygen absorber Shading, sealed, 40 ° C, 6 months Non-shading, sealed, 40 ° C, 6 months Shading, sealed with large amount of air, 40 ° C, 6 months As shown in Table 3, the results showed that lycopene was quite stable under the storage conditions,
The lycopene content decreased and the quality of the powder deteriorated. From these results, it can be seen that it is desirable to seal the light-shielding and enclose an oxygen scavenger for storage of the lycopene composition according to the present invention.
【００２３】[0023]
【表３】 [Table 3]
【００２４】実施例２（健康食品への利用） リコペン粉末（リコペン含量１０％）５０ｇ、バレイシ
ョデンプン５０ｇ、乳糖５０ｇ及び結晶セルロース１０
ｇをよく混和し、カプセルに充填し、１カプセル中にリ
コペン１０ｍｇを含有する健康食品とした。Example 2 (Use for Health Food) 50 g of lycopene powder (lycopene content 10%), 50 g of potato starch, 50 g of lactose and 10 g of crystalline cellulose
g was mixed well and filled into capsules to give a health food containing 10 mg of lycopene in one capsule.
【００２５】実施例３（健康食品への利用） 下記原料を水に混合溶解して１０００ｇとし、加熱殺菌
（９８℃、３分）し、冷却後、無菌濾過し、５０ｇずつ
ガラズ瓶に無菌充填し、リコペンを０．０６％含有する
ドリンク剤タイプの健康食品とした。 リコペン組成物（リコペン含量１０％） ６．０ｇ ブドウ糖 ３００．０ｇ クエン酸 １０．０ｇ ビタミンＣ １．０ｇ 無水カフェイン ０．３ｇ ニコチン酸アミド ０．２ｇ 水 ６８２．５ｇExample 3 (Utilization for health food) The following ingredients were mixed and dissolved in water to make 1000 g, sterilized by heating (98 ° C., 3 minutes), cooled, sterile-filtered, and aseptically filled into glass bottles in 50 g portions. Then, a drink-type health food containing 0.06% lycopene was prepared. Lycopene composition (lycopene content 10%) 6.0 g glucose 300.0 g citric acid 10.0 g vitamin C 1.0 g anhydrous caffeine 0.3 g nicotinamide 0.2 g water 682.5 g
【００２６】実施例４（健康志向食品への利用） リコペン組成物（リコペン含量１０％） ３０ｇ オレンジジュース ４００ｇ キャロットジュース ３７０ｇ クランベリージュース ２００ｇ 上記原料をミキサーにて均一混合し、ドリンクタイプの
健康志向食品とした。Example 4 (Utilization for health-conscious food) Lycopene composition (lycopene content: 10%) 30 g Orange juice 400 g Carrot juice 370 g Cranberry juice 200 g The above ingredients are uniformly mixed with a mixer to obtain a drink-type health-conscious food. did.
【００２７】実施例５（健康志向食品への利用） 砂糖 ４５０ｇ 水飴 ４２８ｇ 水 ５０ｇ 果汁 ２０ｇ 増粘剤 ２０ｇ アスコルビン酸 １０ｇ リコペン組成物（リコペン含量１０％） １００ｇ 香料 １ｇ β−カロチン １ｇ 上記原料を常法に従い５ｇ／個のキャンディーを製造し
た。得られたキャンディーは１００ｇ当たり０．１ｇの
リコペンを含有するキャンディータイプの健康志向食品
とした。Example 5 (Use for health-oriented foods) Sugar 450 g Sugar beet 428 g Water 50 g Fruit juice 20 g Thickener 20 g Ascorbic acid 10 g Lycopene composition (lycopene content 10%) 100 g Flavor 1 g Beta-carotene 1 g To produce 5 g / candy. The obtained candy was a candy-type health-conscious food containing 0.1 g of lycopene per 100 g.
【００２８】実施例６（医薬組成物への利用） 配合原料： （１）リコペン組成物（リコペン含量１０％） ６０ｇ （２）マンニット ２００ｇ （３）バレイショデンプン ４７ｇ （４）ステアリン酸マグネシウム ３ｇ 上記（１）と（２）を混合し、これに（３）を１０％デ
ンプン糊として加え、粒状化し、これをＮｏ．６０メッ
シュ（Ｂ．Ｓ．）のふるいを通し、更にＮｏ．１６メッ
シュ（Ｂ．Ｓ．）のふるいで選別し、この粒子を（４）
と混合した後、打錠機で直径１０ｍｍ、１錠当りの重量
が５００ｍｇの錠剤（リコペン２％含有）とし、医薬組
成物とした。Example 6 (Utilization for pharmaceutical composition) Ingredients: (1) Lycopene composition (Lycopene content 10%) 60 g (2) Mannit 200 g (3) Potato starch 47 g (4) Magnesium stearate 3 g (1) and (2) were mixed, and (3) was added as a 10% starch paste, and granulated. Through a 60 mesh (BS) sieve. A 16 mesh (BS) sieve is used to separate the particles, and the particles are separated into (4)
After that, tablets having a diameter of 10 mm and a weight per tablet of 500 mg (containing 2% of lycopene) were obtained using a tableting machine to obtain a pharmaceutical composition.
【００２９】実施例７ （化粧品への利用） 以下の配合割合（重量％）で混合し全量を１００ｋｇと
し、リコペンを０．１％含有する化粧水とした。 リコペン組成物（リコペン含量１０％） １ エタノール ９ 乳酸 ０．２ クエン酸 ０．９ ソルビット ４ パラオキシ安息香酸メチル ０．１ 香料 適量 精製水 残余Example 7 (Utilization in cosmetics) The following mixture ratio (% by weight) was mixed to make the total amount 100 kg, and a lotion containing 0.1% of lycopene was prepared. Lycopene composition (lycopene content 10%) 1 Ethanol 9 Lactic acid 0.2 Citric acid 0.9 Sorbit 4 Methyl parahydroxybenzoate 0.1 Perfume Appropriate amount Purified water residue
【００３０】実施例８ （動物用飼料への利用） ペットフード配合割合（重量％）小麦粉６６、大豆蛋白
質１６、チーズ６、脂肪３、炭酸カルシウム３、フマー
ル酸１、食塩２、ミネラル類１、リコペン組成物（リコ
ペン含量１０％）２、上記配合により混合した後、常法
により造粒しリコペン０．２％を含有する粒状組成物と
し、動物用飼料とした。Example 8 (Use in animal feed) Pet food blending ratio (% by weight) Flour 66, soy protein 16, cheese 6, fat 3, calcium carbonate 3, fumaric acid 1, salt 2, minerals 1, After mixing the lycopene composition (lycopene content 10%) 2 and the above mixture, the mixture was granulated by a conventional method to obtain a granular composition containing 0.2% lycopene, which was used as animal feed.
【００３１】[0031]
【発明の効果】本発明によれば、安全衛生上好ましくな
い有機溶媒（例えばヘキサンや酢酸エチル、ジクロロメ
タン、石油エーテル等）を使用することなく安全に、か
つ、高い水分散性性を有した、安定で、高純度のリコペ
ン組成物、およびその製造法、並びに健康食品、食品、
食品添加物、医薬品、化粧品、又は動物用飼料への用途
を提供することができる。According to the present invention, high water dispersibility can be obtained safely without using an organic solvent (for example, hexane, ethyl acetate, dichloromethane, petroleum ether, etc.) which is not preferable for safety and health. Stable, high-purity lycopene composition, and its production method, and health food, food,
Uses for food additives, pharmaceuticals, cosmetics, or animal feeds can be provided.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ２３Ｌ 1/212 Ａ２３Ｌ 1/212 Ｚ ４Ｃ０８３ 1/303 1/303 ４Ｃ２０６ 2/52 Ａ６１Ｋ 7/00 Ｍ Ａ６１Ｋ 7/00 Ｃ 31/01 31/01 Ａ６１Ｐ 3/02 Ａ６１Ｐ 3/02 Ａ２３Ｌ 2/02 Ｚ // Ａ２３Ｌ 2/02 2/00 Ｆ (72)発明者 戸邉 光一朗 千葉県野田市野田250番地キッコ−マン株 式会社内 (72)発明者 河原木 正次 東京都中央区日本橋小網町４番13号 日本 デルモンテ株式会社 (72)発明者 若山 忠明 東京都中央区日本橋小網町４番13号 日本 デルモンテ株式会社 (72)発明者 石村 英二 東京都中央区日本橋小網町４番13号 日本 デルモンテ株式会社 Ｆターム(参考） 2B150 AA06 DA02 DD31 DD57 4B014 GB06 GK06 GL03 GP01 4B016 LC07 LG11 LK03 LP02 LP08 4B017 LC03 LG02 LG04 LG06 LG07 LK06 LK07 LK16 LP01 4B018 LB01 LB08 LE02 LE05 MD07 MD08 MD24 MD53 MF01 MF06 4C083 AC011 AC102 AC132 AC302 AC482 CC04 DD23 EE12 FF01 4C206 BA02 MA01 MA04 MA72 ZC21──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI theme coat ゛ (Reference) A23L 1/212 A23L 1/212 Z 4C083 1/303 1/303 4C206 2/52 A61K 7/00 M A61K 7 / 00 C 31/01 31/01 A61P 3/02 A61P 3/02 A23L 2/02 Z // A23L 2/02 2/00 F (72) Inventor Koichiro Tobe 250 Noda, Noda, Chiba, Japan (72) Inventor Shoji Kawaharaki 4-13 Nihonbashi Koamicho, Chuo-ku, Tokyo Japan Del Monte Co., Ltd. (72) Inventor Tadaaki Wakayama 4-13 Nihonbashi Koamicho, Chuo-ku, Tokyo Japan Del Monte Co., Ltd. (72) Inventor Eiji Ishimura 4-13 Nihonbashi Koamicho, Chuo-ku, Tokyo Japan Del Monte F-term (reference) 2B150 AA06 DA02 DD31 DD57 4B014 GB06 GK06 GL03 GP01 4B016 LC07 LG11 LK03 LP02 LP08 4B017 LC03 LG02 LG04 LG06 LG07 LK06 LK07 LK16 LP01 4B018 LB01 LB08 LE02 LE05 MD07 MD08 MD24 MD53 MF01 MF06 4C083 AC011 AC102 AC132 AC302 AC482 CC04 DD23 EE12 FF01 4C206 MA02 MA01 MA01
Claims (6)
で、且つエタノール以外の製造用有機溶媒の残留が皆無
で安全なリコペン組成物。1. A safe lycopene composition having a lycopene content of 9% by weight or more in terms of anhydrous content and having no residual organic solvent for production other than ethanol.
請求項１記載のリコペン組成物。2. The lycopene composition according to claim 1, wherein the lycopene composition is water-dispersible and stable.
ノール分別することにより調製したリコペン液を、乾燥
後、エタノール洗浄し、次いで溶媒を除去することを特
徴とする請求項１又は２記載のリコペン組成物の製造
法。3. The method according to claim 1, wherein the lycopene solution prepared by centrifuging, microfiltration and ethanol fractionation of the processed tomato product is dried, washed with ethanol, and then the solvent is removed. A method for producing a lycopene composition.
外線加熱乾燥である請求項３記載のリコペン組成物の製
造法。4. The method for producing a lycopene composition according to claim 3, wherein the drying method is microwave irradiation drying or far infrared heating drying.
が３０〜１００容量％である請求項３記載のリコペン組
成物の製造法。5. The method for producing a lycopene composition according to claim 3, wherein the concentration of ethanol used for washing with ethanol is 30 to 100% by volume.
有する健康食品、食品、食品添加物、医薬品、化粧品又
は動物用飼料。6. A health food, food, food additive, pharmaceutical, cosmetic or animal feed containing the lycopene composition according to claim 1 or 2.
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| JP2004059518A (en) * | 2002-07-30 | 2004-02-26 | Enkaku Iryo Kenkyusho:Kk | Muscle protein degradation inhibitor and functional food and drink |
| ES2241503A1 (en) * | 2005-04-19 | 2005-10-16 | Eduardo Sabio Rey | Method of preparing lycopene-enriched formulations that are free of organic solvents, formulations thus obtained, compositions comprising said formulations and use of same |
| JP2007502800A (en) * | 2003-08-21 | 2007-02-15 | ネステク ソシエテ アノニム | Natural lycopene concentrate and production method |
| KR100718346B1 (en) * | 2005-04-27 | 2007-05-14 | 계명대학교 산학협력단 | An antimicrobial composition comprising lycopene having antimicrobial activity |
| KR100903840B1 (en) | 2007-08-14 | 2009-06-25 | 진주산업대학교 산학협력단 | Preparation method for High Concentration Lycopene of Tomato and Use Thereof |
| JP2012211169A (en) * | 2004-02-10 | 2012-11-01 | Nestec Sa | Composition containing cis-isomer of carotenoid compound and process |
| WO2013125281A1 (en) | 2012-02-24 | 2013-08-29 | 富士フイルム株式会社 | Lycopene-containing composition |
| KR101379116B1 (en) | 2011-12-16 | 2014-04-01 | 한국식품연구원 | Preparation method of rice starch syrup comprising lycopene |
| US9044407B2 (en) | 2006-04-03 | 2015-06-02 | Health Ever Bio-Tech Co., Ltd. | Multi-carotenoids compositions and uses therefor |
| CN112618426A (en) * | 2020-06-29 | 2021-04-09 | 昆仑技术研究(广州)有限公司 | Preparation method and application of water-in-oil type white tomato freeze-dried powder |
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| JP2004059518A (en) * | 2002-07-30 | 2004-02-26 | Enkaku Iryo Kenkyusho:Kk | Muscle protein degradation inhibitor and functional food and drink |
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| US9044407B2 (en) | 2006-04-03 | 2015-06-02 | Health Ever Bio-Tech Co., Ltd. | Multi-carotenoids compositions and uses therefor |
| US10022414B2 (en) | 2006-04-03 | 2018-07-17 | Health Ever Bio-Tech Co., Ltd. | Multi-carotenoids compositions and methods |
| KR100903840B1 (en) | 2007-08-14 | 2009-06-25 | 진주산업대학교 산학협력단 | Preparation method for High Concentration Lycopene of Tomato and Use Thereof |
| KR101379116B1 (en) | 2011-12-16 | 2014-04-01 | 한국식품연구원 | Preparation method of rice starch syrup comprising lycopene |
| WO2013125281A1 (en) | 2012-02-24 | 2013-08-29 | 富士フイルム株式会社 | Lycopene-containing composition |
| KR20140123080A (en) | 2012-02-24 | 2014-10-21 | 후지필름 가부시키가이샤 | Lycopene-containing composition |
| CN112618426A (en) * | 2020-06-29 | 2021-04-09 | 昆仑技术研究(广州)有限公司 | Preparation method and application of water-in-oil type white tomato freeze-dried powder |
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