JP2002087959A5 - - Google Patents
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- Publication number
- JP2002087959A5 JP2002087959A5 JP2000278154A JP2000278154A JP2002087959A5 JP 2002087959 A5 JP2002087959 A5 JP 2002087959A5 JP 2000278154 A JP2000278154 A JP 2000278154A JP 2000278154 A JP2000278154 A JP 2000278154A JP 2002087959 A5 JP2002087959 A5 JP 2002087959A5
- Authority
- JP
- Japan
- Prior art keywords
- nilvadipine
- tablet
- easily absorbable
- organic solvent
- fluidized bed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FAIIFDPAEUKBEP-UHFFFAOYSA-N Nilvadipine Chemical compound COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC([N+]([O-])=O)=C1 FAIIFDPAEUKBEP-UHFFFAOYSA-N 0.000 claims description 8
- 229960005366 nilvadipine Drugs 0.000 claims description 8
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000000654 additive Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000278154A JP3968687B2 (ja) | 2000-09-13 | 2000-09-13 | 易吸収性ニルバジピン錠 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000278154A JP3968687B2 (ja) | 2000-09-13 | 2000-09-13 | 易吸収性ニルバジピン錠 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003281585A Division JP2004002460A (ja) | 2003-07-29 | 2003-07-29 | 易吸収性ニルバジピン錠の製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002087959A JP2002087959A (ja) | 2002-03-27 |
| JP2002087959A5 true JP2002087959A5 (https=) | 2004-08-12 |
| JP3968687B2 JP3968687B2 (ja) | 2007-08-29 |
Family
ID=18763360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000278154A Expired - Fee Related JP3968687B2 (ja) | 2000-09-13 | 2000-09-13 | 易吸収性ニルバジピン錠 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3968687B2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003146878A (ja) * | 2002-11-22 | 2003-05-21 | Sawai Pharmaceutical Co Ltd | ニルバジピン含有易溶性固形製剤およびその製造法 |
| CA2525970C (en) | 2003-05-15 | 2011-03-22 | Roskamp Research, Llc | Use of nilvadipine for reducing amyloid deposition, amyloid neurotoxicity and microgliosis |
| TWI500422B (zh) | 2007-10-05 | 2015-09-21 | Alzheimer S Inst Of America Inc | 以（－）－尼代地平（ｎｉｌｖａｄｉｐｉｎｅ）對映異構物減低類澱粉沉積、類澱粉神經毒性及微神經膠細胞增生之方法 |
-
2000
- 2000-09-13 JP JP2000278154A patent/JP3968687B2/ja not_active Expired - Fee Related
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