JP2002078801A - Liquid infusing instrument - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liquid infusing instrument capable of completing readiness for infusing a liquid such as liquid medicines with simple operation. SOLUTION: The liquid infusing instrument 1 comprises an outer cylinder 3 having a liquid guide portion 4 with an end opening (a liquid guide port) 42 formed at the end, a film 7 for shielding the end opening 42, a film breaking member 13 for breaking the film to open the end opening 42, and a hub (an operating member) 11 having the film breaking member 13 inside for moving the film breaking member 13 relative to the liquid guide portion 4 and giving breaking operation to the film 7. The hub 11 can be moved to a first position, where the film 7 is not broken, and a second position, where the film 7 is to be broken. The film breaking member 13 has a fixed portion 14 to be fixed to the hub 11 and a protruded portion 15 erected on the fixed portion 14 for breaking the film 7, and the fixed portion 4 has a through hole 141 through which the liquid passes.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a liquid injection device.

[0002]

2. Description of the Related Art A prefilled syringe in which a drug solution or the like is stored in advance is known. This prefilled syringe includes an outer cylinder having a discharge port at the tip, a gasket inserted into the outer cylinder, and a plunger (pusher) connected to the gasket, and is surrounded by the outer cylinder and the gasket. The liquid medicine is stored in the space where the liquid is stored.

[0003] Further, in order to leak the chemical solution from the outlet and to maintain the sterility of the chemical solution, a film for sealing the outlet in a liquid-tight manner is attached to the outlet.

In such a prefilled syringe, when administering a drug solution in an outer cylinder to a patient, first, a film for sealing an outlet is peeled off, and then an injection needle having a needle body at the tip of the outer cylinder. Attach. Then, in this state, the needle is punctured into the blood vessel of the patient, and the plunger is pressed toward the distal end of the outer cylinder to inject the drug solution into the blood vessel.

Conventionally, these prefilled syringes and injection needles are separately packaged.

[0006] Therefore, the operation until the preparation for administering the drug solution in the outer cylinder to the patient is completed is complicated and time-consuming. In particular, quick response is indispensable for emergency patients, but it is disadvantageous when a drug solution is administered to such patients.

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a liquid injecting device which can complete the preparation for injecting a liquid such as a chemical solution with a simple operation.

[0008]

This and other objects are achieved by the present invention which is defined below as (1) to (12).

(1) An outer cylinder having a liquid guide portion forming a liquid guide port at a tip, a film for shielding the liquid guide port, and a rupture member for breaking the film to open the liquid guide port. And an operation member that includes the membrane rupture member therein and moves the membrane rupture member relative to the liquid guide portion to perform an operation of breaking the film, and the operation member includes: A liquid injection device configured to be movable to a first position where the film is not broken and a second position where the film is broken.

(2) The liquid injection device according to the above (1), wherein the membrane rupture member has a fixing portion fixed to the operation member, and a projection standing upright on the fixing portion to break the film. Appliances.

(3) The liquid injection device according to the above (2), wherein the fixing portion has at least one hole through which a liquid passes.

(4) The liquid injection device according to the above (3), wherein the projection is formed along a longitudinal direction thereof and has a groove or a hole communicating with the hole.

(5) The liquid injection device according to any one of (2) to (4), wherein the protruding portion has a pointed end opposite to the fixing portion.

(6) Any of (1) to (5) above, further comprising a liquid-tight means for maintaining the liquid-tightness between the liquid guide portion and the operation member when at least the operation member is at the second position. A liquid injection device according to any one of the above.

(7) The thickness of the film is 0.1 to 2.0.
The liquid injection device according to any one of the above (1) to (6), which is mm.

(8) The liquid injection device according to any one of (1) to (7), further including first holding means for holding the operation member at the first position.

(9) The first holding means is detachable with respect to the liquid injection device, and is provided between the operating member and the outer cylinder to prevent a spacer portion from approaching. The liquid injection device according to the above (8), having the liquid injection device.

(10) The liquid injection device according to any one of (1) to (9), further including a second holding means for holding the operation member at the second position.

(11) The liquid injection device according to any one of the above (1) to (10), wherein the operation member holds a needle tube at a distal end thereof.

(12) The liquid injection device according to (11), wherein the operation member also serves as a hub of the needle tube.

[0021]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a liquid injection device according to the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings. In the following description, a liquid injection device in which a liquid is stored in advance will be described as a representative.

<First Embodiment> FIG. 1 is a partial cross-sectional view of a liquid injection device of the present invention, and FIG. 2 is a configuration of a distal end portion of the liquid injection device of the first embodiment (a state in which a hub is at an unruptured position). ), FIG. 3 is a longitudinal sectional view showing the configuration of the distal end portion of the liquid injection device of the first embodiment (in a state where the hub is at a break position), and FIG. 4 is a liquid injection device of the first embodiment. FIG. 5 is a side view of the rupture member provided in the device, and FIG. 5 is a plan view of the rupture member provided in the liquid injection device according to the first embodiment. In the following description, the upper side in FIGS. 1 to 4 is referred to as a “proximal end” and the lower side is referred to as a “distal end”.

The liquid injection device 1 shown in FIG. 1 includes a liquid injection device main body (prefilled syringe) 2 and an injection needle 10 attached to the distal end of the liquid injection device main body 2.
Hereinafter, the configuration of each unit will be described.

The liquid injection device main body 2 includes an outer cylinder (syringe outer cylinder) 3, a liquid guide 4 formed at the distal end of the outer cylinder 3 to form a distal end opening 42, and a liquid guide 4 inside the outer cylinder 3. The gasket 5 includes a gasket 5 that can slide in a liquid-tight manner, a plunger (pusher) 6 that is connected to the gasket 5 and moves the gasket 5 within the outer cylinder 3, and a film 7 that shields the distal end opening 42.

The outer cylinder 3 is formed of a bottomed cylindrical member having a bottom 31. A liquid storage space 33 is formed in a portion surrounded by a gasket 5 described later.

The liquid is stored in the liquid storage space 33. Examples of the liquid include saccharide injections such as glucose, electrolyte correction injections such as sodium chloride and potassium lactate, vitamins, vaccines, antibiotics injections, contrast agents, steroids, protease inhibitors, Examples thereof include various drug solutions such as fat emulsions, anticancer agents, anesthetics, stimulants, and narcotics, or distilled water, disinfectants, liquid foods, alcohols, and the like.

A plate-like flange 3 is provided on the outer periphery of the base end of the outer cylinder 3.
2 are integrally formed. When the plunger 6 is moved relative to the outer cylinder 3, the flange 3
2 can be operated with a finger.

The constituent materials of the outer cylinder 3 and a plunger 6 described later are, for example, cyclic polyolefins (for example, ethylene and tetracyclo [4.4.0.1).
^2.5 . ^17.10 ] -3-dodecene copolymer), polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-
Styrene copolymer, polyester such as polyethylene terephthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6.6, nylon 6
And various resins such as 10, nylon 12), polyethersulfone, and polysulfone. Among them, cyclic polyolefins (e.g., ethylene and tetracyclo [4.4.0.1) are preferable in terms of ease of molding.
^2.5 . ^17.10 ] -3-dodecene copolymer), polypropylene, polyester, poly- (4-methylpentene-
1), resins such as polyethersulfone and polysulfone.

It is preferable that the constituent material of the outer cylinder 3 is substantially transparent in order to secure the visibility of the inside.

A liquid guide portion (diameter-reduced portion) 4 having a diameter smaller than that of the body of the outer cylinder 3 and protruding toward the front end is formed integrally at the front end of the outer cylinder 3 at the center of the bottom 31. Have been.

The liquid guide portion 4 has a liquid guide passage 41 formed therein to communicate with the liquid storage space 33. The liquid passage 41 is substantially constant in the axial direction (longitudinal direction),
It is opened at the tip of the liquid guide part 4 to form a tip end opening (liquid guide port) 42.

The diameter D1 of the tip opening 42 and the length L1 of the liquid guide 4 are not particularly limited, but are preferably set small.

As a result, the amount of liquid remaining in the liquid guide channel 41 of the liquid guide section 4 can be sufficiently reduced.

A membrane (seal member) 7 is fixed (attached) to the leading end of the liquid guide portion 4 so as to close (shield) the leading end opening 42. Thereby, the tip opening 42 is
It is sealed in a liquid-tight manner by the film 7.

As a method of fixing the film 7 to the liquid guide portion 4, for example, fusion (thermal fusion, ultrasonic fusion, high frequency fusion, or the like), adhesion with an adhesive, or the like can be used.

The thickness of the film 7 is not particularly limited, but is, for example, preferably about 0.1 to 2.0 mm, and more preferably about 0.4 to 1.7 mm. By setting the thickness of the film 7 within the above range, the film 7 can be easily and reliably broken by the film rupture member 13 described later.

The constituent material of the membrane 7 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber and silicone rubber, polyurethane-based materials,
Elastic materials such as polyester-based, polyamide-based, olefin-based, and styrene-based thermoplastic elastomers, and mixtures thereof.

A gasket 5 made of an elastic material is housed in the outer cylinder 3. Gasket 5 is hollow 5
The hollow portion 51 has a plunger 6 to be described later.
Head part 63 is fitted.

The gasket 5 slides in the outer cylinder 3 in the axial direction (longitudinal direction) of the outer cylinder 3 by operating the plunger 6.

On the outer peripheral portion of the gasket 5, a pair of ring-shaped protrusions 52 are formed at predetermined intervals in the axial direction. The protrusion 52 slides while being in close contact with the inner peripheral surface 34 of the outer cylinder 3, so that liquid tightness is more reliably maintained and slidability is improved.

As the constituent material of the gasket 5, for example, the same materials as those described for the film 7 can be used.

The outer periphery of the gasket 5 is made of, for example, polytetrafluoroethylene or a copolymer thereof.
Ethylene-tetrafluoroethylene copolymer, ethylene tetrafluoride, PVdE (polyvinylidene fluoride), P
CTFE (polychlorotrifluoroethylene), TFE
(Tetrafluoroethylene), a film composed of a fluorine-based resin such as FEP (fluorinated ethylene propylene),
Alternatively, it may be covered with a film made of a resin such as PE (polyethylene) or HDPE (high-density polyethylene). Thereby, the slidability of the gasket 5 on the inner peripheral surface 34 of the outer cylinder 3 is improved.

A plunger 6 for moving the gasket 5 in the outer cylinder 3 in the axial direction is connected to the gasket 5.

The plunger 6 is mainly composed of a plate piece having a cross-shaped cross section, and a plate member 61 is integrally formed on the tip side. Also, at the base end of the plunger 6,
A plate-like flange 62 is integrally formed. The plunger 6 is operated by putting a finger or the like on the flange 62.

At the tip of the plunger 6, there is formed a mushroom-shaped head (connecting portion) 63 which is inserted and fitted into the hollow portion 51 of the gasket 5.

An injection needle 10 is provided at the distal end of the liquid injection device main body 2 so as to be movable in the axial direction of the liquid injection device main body 2.

The injection needle 10 has a hub 11 and the hub 11
The needle tube 12 fixed (held) at the tip of the hub 1 and the hub 1
1 and a membrane rupture member 13 installed inside.

The membrane rupture member 13 has a function of breaking the membrane 7, and includes a fixing portion 14 fixed to the hub 11, which will be described later, and a projection 15 erected on the fixing portion 14.

The fixing portion 14 is formed of a disk-shaped member.
The hub 11 is installed so as to divide (isolate) the inside of the hub 11 in the vertical direction in FIGS. 2 and 3.

A plurality of holes 141 are formed in the fixing portion 14 so as to pass through the fixing portion 14 as flow paths through which the liquid can pass. In the present embodiment, as shown in FIG. 5, four holes 141 are provided at substantially 90 ° intervals about a central axis (axis) of the fixed portion 14 at a substantially central portion thereof.
Each of the holes 141 has a substantially fan-shaped cross-sectional shape, and has substantially the same dimensions.

Therefore, when the ends of the arcs (outer edges) of the adjacent holes 141 are connected to each other by arcs indicated by a chain line in FIG. 5, an imaginary circle 141a having a diameter D2 can be drawn. The diameter D2 is not particularly limited, but in relation to the diameter D1 of the distal end opening 42, D2 / D1 is, for example,
It is preferably about 0.5 to 1.5, and 0.8 to 1.
More preferably, it is about 2. If the diameter D2 is smaller than the above lower limit, the cross-sectional area of each hole 141 becomes small, so that when the liquid is discharged from the liquid storage space 33, the liquid may not pass through each hole 141 efficiently. If the diameter D2 is too large, the portion occupied by each hole 141 in the fixing portion 14 becomes large, and the fixing portion 14 may have insufficient strength depending on its material.

The number and the shape of the holes 141 are not limited to those shown in the figure, and it is sufficient that at least one hole 141 is provided in the fixing portion 14. For example, a polygon such as a circle, an ellipse, a triangle, a quadrangle, and a rhombus may be used.

Further, a convex portion 142 protruding outward in a ring shape is formed on the outer periphery of the distal end portion of the fixed portion 14. The convex portion 142 is provided with a concave portion 11 of the hub 11 described later.
Engage with 1.

The fixed portion 14 is integrally formed with a flat plate-like projection 15 which stands substantially perpendicularly to the base end surface 143 thereof.

The projecting portion 15 is provided at the front end opening 4 of the liquid guiding portion 4.
The film 7 that shields 2 is broken, and the tip opening 42 is opened.

The cross-sectional area of the projecting portion 15 gradually decreases toward the base end and becomes minimum at the base end (the end opposite to the fixing portion 14) to form the top 151.
That is, the protruding portion 15 has a sharp base end. Thereby, the protrusion 15 can easily and surely break the film 7.

The maximum width (length in the horizontal direction in FIG. 4) of the projection 15 is set slightly smaller than the diameter D1 of the distal end opening 42. Accordingly, when the membrane 7 is broken by the membrane rupture member 13, the protrusion 15 is inserted into the liquid guide passage 41 to the vicinity of the base (almost the whole), and the membrane 7 can be more reliably broken. it can.

The height (length in the vertical direction in FIG. 4) of the projection 15 is not particularly limited, and may be any thickness as long as it is equal to or greater than the thickness of the film 7. Thereby, the projection 15 can suitably exhibit its function.

Examples of the constituent material of the membrane rupture member 13 include various metal materials such as aluminum or aluminum alloy, stainless steel, titanium or titanium alloy, polycarbonate, polymethyl methacrylate, polyimide, polysulfone, polyphenylene sulfide, and polyphenylene sulfide. Examples include various resin materials such as ether ether ketone, polyacetal, liquid crystal polymer, and polybutylene terephthalate, and various ceramic materials such as alumina and hydroxyapatite.

The hub 11 having the membrane rupture member 13 therein,
It is formed of a substantially cylindrical member, and has a tapered shape whose inner and outer diameters gradually increase in the proximal direction.

The hub 11 functions as an operation member for operating the membrane rupture member 13, and as shown in FIG. 2, a first position where the membrane 7 is not broken (hereinafter referred to as an “unruptured position”). 3), and as shown in FIG. 3, the film 7 can be moved to a second position at which the film 7 is broken (hereinafter, referred to as a “break position”).

Thus, the hub 11 can perform an operation of moving the membrane rupture member 13 relative to the liquid guide portion 4 to break the membrane 7.

On the inner periphery of the distal end of the hub 11, there is formed a recess 111 which is recessed in a ring shape. By engaging (fitting) the concave portion 111 and the convex portion 142 of the fixing portion 14, the fixing portion 14, that is, the membrane rupture member 13 is fixed to the hub 11.

The fixing portion 14 may be fixed (attached) to the hub 11 only by an engaging force, but may be, for example, fusion (heat fusion, high frequency fusion, ultrasonic fusion, etc.), adhesive It may be fixed by a method such as bonding with an agent.

In this embodiment, the hub 11 and the rupture member 13 are formed as separate members. However, the hub 11 and the rupture member 13 may be formed integrally.

When the membrane rupture member 13 is fixed (installed) to the hub 11, the distance (the length L 2 in FIG. 2) between the base end of the hub 11 and the base end surface 143 of the fixing portion 14 is equal to the length of the liquid guide 4. Length L1
Is set to be substantially equal to, or slightly smaller than. Accordingly, when the hub 11 is at the break position (see FIG. 3), the distal end surface 43 of the liquid guide portion 4 and the proximal end surface 143 of the fixing portion 14 can be more reliably brought into contact (pressure contact). Therefore, the liquid guide path 41 and each of the holes 141 can be more reliably communicated with each other, so that when the liquid is discharged from the liquid storage space 33, the liquid can pass through each of the holes 141 more efficiently.

In this case, the volume of the internal space of the hub 11 defined by the distal end surface 43 of the liquid guide 4 and the base end surface 143 of the fixing portion 14 can be reduced. The amount of remaining liquid can be reduced. Therefore, especially when an expensive chemical liquid is stored as a liquid in the liquid storage space 33, there is an advantage that the chemical liquid can be effectively used.

A flange 112 protruding in a ring shape is integrally formed on the outer periphery of the base end of the hub 11.
For example, when the hub 11 is moved relative to the liquid guide 4, the operation can be performed by putting a finger or the like on the flange 112.

The hub 11 is preferably made of a transparent (colorless and transparent), colored transparent or translucent resin, and the internal visibility is secured.

The constituent material of the hub 11 is not particularly limited. For example, polyolefin such as polyethylene, polypropylene, polybutadiene, ethylene-vinyl acetate copolymer, polyvinyl chloride, polyurethane, polystyrene, polymethyl methacrylate, polycarbonate, polyamide Polyester, acrylic resin, such as polyethylene terephthalate, polybutylene terephthalate, A
BS resin, AS resin, ionomer, polyacetal,
Various resin materials such as polyphenylene sulfide and polyether ether ketone are exemplified.

A hollow needle tube 12 is fixed (fixed) to the tip of the hub 11, and the lumen 121 of the needle tube 12 is
Communicates with the interior of the

The needle tube 12 is made of, for example, a metal material such as stainless steel, aluminum or an aluminum alloy, titanium or a titanium alloy. A sharp needle tip 122 is formed at the distal end of the needle tube 12. The shape of the needle tip 122 is not particularly limited, and in the present embodiment,
It has a shape having a blade surface inclined at a predetermined angle with respect to the axis of the needle tube 12.

Fixing (fixing) of needle tube 12 to hub 11
Examples of the method include a method of fitting, caulking, fusing, bonding with an adhesive, and the like, or a method using these together.

It is preferable that at least the inside of such a liquid injecting instrument 1 is previously subjected to a sterilization treatment such as high-pressure steam sterilization, gas sterilization or radiation sterilization.

Further, in such a liquid injection device 1, when at least the hub (operation member) 11 is at the breaking position (second position), the liquid-tightness that maintains the liquid-tightness between the liquid guide portion 4 and the hub 11 is maintained. Means 8 are provided. The liquid-tight means 8 will be described below with reference to FIGS.

A liquid-tight portion 81 is formed on the outer periphery of the leading end of the liquid guide 4 so as to protrude outward in a ring shape.

When the hub 11 is moved in the proximal direction with respect to the liquid guide portion 4 to be at the break position (see FIG. 3), the outer peripheral surface of the liquid-tight portion 81 is in close contact with the inner peripheral surface 82 of the hub 11. Further, at this time, the distal end surface 43 of the liquid guide unit 4 is in close contact with the base end surface 143 of the fixing unit 14. Thereby, the adhesion between the liquid guide 4 and the hub 11 is maintained.

That is, in the present embodiment, the liquid-tight portion 81, the inner peripheral surface 82 of the hub 11, and the distal end surface 43 of the liquid guide 4 are provided.
The liquid-tight means 8 is constituted by the base end surface 143 of the fixing portion 14.

The liquid-tight portion 81 is made of, for example, a material having elasticity. The liquid-tight portion 81 is in close contact with the inner peripheral surface 82 of the hub 11 and the hub 11 is moved from an unruptured position (first position). You may make it move to a breaking position (2nd position). In this case, since the liquid in the liquid storage space 33 is more reliably prevented from coming into contact with the atmosphere, it is possible to more reliably prevent foreign substances from being mixed into the liquid and contamination by bacteria and the like.

The liquid-tight portion 81 is not limited to the one shown in the drawing. For example, the liquid-tight portion 81 may be formed along the longitudinal direction of the liquid guide portion 4 so that its outer shape corresponds to the inner shape of the hub 11. Good. In this case, assuming that the hub 11 is located at the breaking position, the liquid-tight portion 81 has substantially the entire outer peripheral surface formed on the inner peripheral surface 82 of the hub 11.
Therefore, the liquid tightness between the liquid guide portion 4 and the hub 11 can be improved.

In such a liquid injection device 1, a stopper S (see FIGS. 1 and 6) and a cap C (see FIG. 1) are mounted when not in use.

The stopper S functions as first holding means for holding the hub 11 at the unbroken position (first position).

The stopper S is made of a substantially C-shaped member that is detachable from the liquid injection device 1 and has a spacer portion S1 and a groove-shaped engaging portion S2. The stopper S has a hole S3 formed in the center thereof. In the liquid injector 1 not used, the proximal end of the liquid guide 4 is inserted into the hole S3, and the stopper S is attached to the liquid injector 1.

The spacer portion S1 is a portion that can be inserted between the hub 11 and the outer cylinder 3 and has a thickness (length in the vertical direction in FIG. 6) that is the base end of the hub 11 at the unbroken position. Is set to be substantially equal to or slightly larger than the distance from the tip of the outer cylinder 3. For this reason, it is possible to prevent the hub 11 at the unruptured position from being reluctantly pushed toward the base end direction and prevent the hub 11 and the outer cylinder 3 from approaching each other (moving the hub 11 to the fractured position). it can. This prevents the membrane 7 from being inadvertently broken by the membrane rupture member 13.

Further, when the stopper S is mounted on the liquid injection device 1, the engagement portion S 2 is provided with the flange 112 of the hub 11.
Engages. This prevents the stopper S from easily detaching (disengaging) from the liquid injection device 1.

The cap C is formed of a bottomed cylindrical member, and is detachably mounted on the distal end side of the hub 11 so as to cover the needle tube 12. This cap C has a function of preventing danger and preventing contamination of the needle tube 12.

As the constituent materials of the stopper S and the cap C, for example, the same constituent materials as those of the outer cylinder 3 and the plunger 6 can be used.

The stopper S and the cap C
Is removed from the liquid injection device 1 when the liquid injection device 1 is used.

The stopper S and the cap C are
It can be omitted as necessary.

Next, an example of a method for using the liquid injection device 1 of the present invention will be described. In the following description, a case where a liquid is injected into a blood vessel of a patient will be described.

[1] First, the liquid injection device 1 housed in a packaging material (not shown) is opened and taken out.
In this state, the stopper S and the cap C are attached to the liquid injection device 1 (see FIG. 1).

By the stopper S, the hub 11 is held at an unruptured position (first position) where the film 7 is not broken (see FIG. 2). As a result, the film 7 is moved to the front end opening 42.
Is sealed in a liquid-tight manner to prevent the liquid in the liquid storage space 33 and the liquid guide channel 41 from leaking out of the liquid injection device main body 2. In addition, the cap C prevents the needle tube 12 from sticking a finger or the like.

[2] Next, the stopper S is removed from the liquid injection device 1. Thereby, the hub 11 is connected to the liquid guide portion 4.
In the proximal direction (upward in FIG. 2).

[3] Next, the outer cylinder 3 of the liquid injection device main body 2 is gripped by hand, and the hub 11 of the injection needle 10 is gripped by the other hand. When gradually moved in the end direction, the membrane rupture member 13 moves in the base end direction with respect to the liquid guide portion 4 with the movement of the hub 11. As a result, the protrusion 151 of the membrane rupture member 13 has the top 151 in contact with the film 7 and further breaks the film 7.

[4] Further, when the hub 11 is moved in the proximal direction with respect to the liquid guide portion 4 and the hub 11 is set at the break position (second position), almost all of the protrusions 15 It is inserted into the channel 41, and the base end surface 143 of the fixed part 14 and the front end surface 43 of the liquid guide part 4 abut (press). Thereby, the liquid guide channel 41 and each hole 141 of the fixing portion 14 are communicated (see FIG. 3).

[5] Next, the cap C is removed from the liquid injection device 1. Thus, the preparation for injecting the liquid in the liquid storage space 33 of the liquid injection device 1 into the blood vessel of the patient is completed.

[6] Then, the needle tube 1 of the liquid injection device 1
2 is punctured into a patient's blood vessel. Thus, the inside of the blood vessel of the patient and the inside of the liquid storage space 33 are separated from each other by the liquid guide channel 41 and each hole 141.
And through the lumen 121 of the needle tube 12 and the like.

[7] When the flange 62 of the plunger 6 is pressed in the distal direction with a finger or the like from the state of the step [5], the gasket 5 moves in the distal direction and the volume of the liquid storage space 33 decreases. . As a result, the liquid sequentially passes through the liquid guide path 41, the distal end opening 42, each hole 141, the space at the distal end of the hub 11, and the lumen 121 of the needle 12, and is administered (injected) into the blood vessel of the patient. .

In this state, the outer peripheral surface of the liquid-tight portion 81 is in close contact with the inner peripheral surface 82 of the hub 11, and the leading end surface 4
3 is in close contact with the base end surface 143 of the fixing portion 14. This prevents the liquid from leaking to the proximal end side of the hub 11.

In such a liquid injection device 1, the stopper S is detached from the liquid injection device 1, and the hub 11 is operated to move the membrane rupture member 13 in the proximal direction with respect to the liquid introduction section 4, and To open the distal end opening 42 to allow the liquid guide channel 41 to communicate with each hole 141.
By just performing the three-stage operation of removing the cap C immediately before puncturing the patient's blood vessel, the preparation for injecting the liquid stored in the liquid storage space 33 of the liquid injection device 1 into the patient's blood vessel is completed. Therefore, the operability is excellent.

<Second Embodiment> Next, a second embodiment of the liquid injection device of the present invention will be described.

FIG. 7 is a side view of a rupture member provided in the liquid injection device of the second embodiment, and FIG. 8 is a plan view of a rupture member provided in the liquid injection device of the second embodiment. Hereinafter, the second embodiment will be described focusing on differences from the first embodiment, and the description of the same items will be omitted.

The second embodiment is the same as the first embodiment except that the shape of the projection 15 of the membrane rupture member 13 is different.

That is, the protruding portion 15 has a conical base end portion and a columnar end portion. In other words, the protrusion 15 has a shape like a pencil as a whole, and its base end is sharp.

With the above configuration,
Functions and effects similar to those of the first embodiment are obtained.

<Third Embodiment> Next, a third embodiment of the liquid injection device of the present invention will be described.

FIG. 9 is a side view of a rupture member provided in the liquid injection device according to the third embodiment. FIG. 10 is a plan view of the rupture member provided in the liquid injection device of the third embodiment. Hereinafter, the third
The embodiment will be described focusing on differences from the first embodiment, and the description of the same items will be omitted.

The third embodiment is the same as the first embodiment except that the shape of the membrane rupture member 13 (fixing portion 14 and protrusion 15) is different.

That is, the fixing portion 14 is formed to be thin. Thereby, the length of each hole 141 (FIG. 1)
1 length in the up-down direction), so that even when the cross-sectional area of each hole 141 is relatively small,
It is possible to pass through each hole 141 efficiently.

On the other hand, the projecting portion 15 is composed of four plate pieces 152 erected radially (at substantially 90 ° intervals) from the central axis (axis) of the fixed portion 14. That is, four grooves 153 are formed between the adjacent plate pieces 152, and the tip of each groove 153 communicates with each hole 141 to form a flow path through which the liquid can pass.

The projecting portion 15 has a cross-sectional shape substantially in the shape of a cross, and is formed continuously with an invariable portion 15a whose cross-sectional shape does not change and a base end side of the invariable portion 15a. Tapered portion 1 whose shape gradually decreases in the proximal direction
5b (see FIG. 11).

The outer diameter (diameter) of the invariable portion 15a is
Is approximately equal to the diameter D1 of the tip opening 42 of
It is set slightly smaller.

The cross-sectional shape of the gradually decreasing portion 15b gradually decreases toward the base end (on the front side in FIG. 12), and is minimized on the central axis of the fixed portion 14. That is, the base of the protrusion 15 (the end opposite to the fixing portion 14) is sharp.

With the above configuration,
Functions and effects similar to those of the first embodiment are obtained. In particular,
The protrusion 15 has a plurality of grooves 153 formed along the longitudinal direction thereof and is configured to communicate each groove 153 with each hole 141. Therefore, when the liquid is discharged from the liquid storage space 33, the liquid becomes It flows along each groove 153, flows into each hole 141, and can pass through each hole 141 more efficiently.

<Fourth Embodiment> FIG. 11 is a sectional view of a membrane rupture member provided in a liquid injection device according to a fourth embodiment.

Hereinafter, the fourth embodiment will be described focusing on the differences from the first embodiment, and the description of the same items will be omitted.

The fourth embodiment is the same as the first embodiment except that the shape of the membrane rupture member 13 (fixing portion 14 and protrusion 15) is different.

That is, the projection 15 is formed of a needle tube having a needle tip 154 whose base end is closed. This needle point 1
Numeral 54 is formed in a substantially conical or shell shape, and a pair of side holes 155 and 155 are formed on the side surfaces thereof so as to face each other.

The lumen (hole) 156 of the projection 15 has a base end opened at each side hole 155, and a tip end thereof communicates with a hole 144 formed at a substantially central portion of the fixing portion 14.

With the above structure,
Functions and effects similar to those of the first embodiment are obtained.

<Fifth Embodiment> FIG. 12 is a longitudinal sectional view showing the configuration of the distal end portion of a liquid injection device according to a fifth embodiment (with the hub at the break position).

Hereinafter, the fifth embodiment will be described focusing on the differences from the first embodiment, and the description of the same items will be omitted.

In the fifth embodiment, the hub (operation member) 11
Is provided at the breaking position (second position), and the other configuration is the same as that of the first embodiment.

That is, the hub 11 has its inner peripheral surface 82
The engagement protrusion 113 protrudes inward in a ring shape.
Are formed. On the other hand, a base corner 811 is formed on the outer periphery of the base end of the liquid-tight portion 81.

When the hub 11 is moved from the unruptured position (first position) toward the base end with respect to the liquid guide portion 4, the engagement projection 113 climbs over the liquid-tight portion 81, and
Reaches the breaking position (second position). At this time, the engaging projection 113 and the base corner 811 of the liquid-tight portion 81 engage (see FIG. 14). This more reliably prevents the hub 11 from returning to the unbroken position once the hub 11 is at the break position.

With the above configuration,
Functions and effects similar to those of the first embodiment are obtained.

The second holding means for holding the hub 11 at the breaking position can be applied to the liquid injection devices of the first to fourth embodiments.

The liquid injection device of the present invention has been described with reference to the illustrated embodiments. However, the present invention is not limited to these embodiments, and the components constituting the liquid injection device exhibit similar functions. It can be replaced with any configuration obtained.

In particular, the rupture member provided in the liquid injection device of the present invention may be a combination of any of the structures shown in the embodiments.

The liquid injection device of the present invention can be used not only for injecting a liquid into a blood vessel of a patient, but also, for example, for transferring a liquid requiring errand adjustment into, for example, an infusion bag or bottle. It can also be used for compounding.

In the liquid injection device of the present invention, what is stored in the liquid storage space is not limited to a liquid, and may be, for example, a solid substance (including a semi-solid substance). In this case, the plunger is moved toward the base end in a state where the liquid guide path and the hole of the fixing portion are in communication with the hub being the break position, thereby increasing the volume of the liquid storage space. Thereby, once a liquid (for example, infusion) capable of dissolving (or dispersing) a solid substance in the liquid storage space is sucked,
After dissolving (or dispersing) the solid substance, the liquid may be injected (discharged).

[0132]

As described above, according to the present invention, the preparation for injecting a liquid such as a chemical can be completed with a simple operation. Therefore, emergency response is advantageous.

In the case where the liquid-tight means is provided, for example, when the liquid is discharged from the inside of the liquid injection device, it is possible to prevent the liquid from leaking out of the liquid injection device from an undesired place.

Further, when the first holding means and the second holding means are provided, it is possible to more reliably prevent liquid leakage or the like due to malfunction.

Further, in the liquid injection device of the present invention, since the residual liquid amount is small, for example, an expensive chemical solution can be injected without waste.

Accordingly, the liquid injection device of the present invention is suitable for application to a prefilled syringe.

[Brief description of the drawings]

FIG. 1 is a partial cross-sectional view of a liquid injection device of the present invention.

FIG. 2 is a vertical cross-sectional view showing a configuration of a distal end portion of the liquid injection device according to the first embodiment (a state in which a hub is at an unbroken position).

FIG. 3 is a longitudinal sectional view showing a configuration (a state in which a hub is at a break position) of a distal end portion of the liquid injection device according to the first embodiment.

FIG. 4 is a side view of a membrane rupture member included in the liquid injection device according to the first embodiment.

FIG. 5 is a plan view of a membrane rupture member included in the liquid injection device according to the first embodiment.

FIG. 6 is a perspective view illustrating a configuration of a stopper.

FIG. 7 is a side view of a membrane rupture member included in the liquid injection device according to the second embodiment.

FIG. 8 is a plan view of a membrane rupture member included in the liquid injection device according to the second embodiment.

FIG. 9 is a side view of a membrane rupture member included in the liquid injection device according to the third embodiment.

FIG. 10 is a plan view of a membrane rupture member included in a liquid injection device according to a third embodiment.

FIG. 11 is a longitudinal sectional view of a membrane rupture member included in a liquid injection device according to a fourth embodiment.

FIG. 12 is a longitudinal sectional view showing a configuration (a state where a hub is at a break position) of a distal end portion of a liquid injection device according to a fifth embodiment.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Liquid injection device 2 Liquid injection device main body 3 Outer cylinder 31 Bottom 32 Flange 33 Liquid storage space 34 Inner peripheral surface 4 Liquid guide part 41 Liquid guide path 42 Tip opening 43 Tip face 5 Gasket 51 Hollow part 52 Projection 6 Plunger 61 Plate Member 62 Flange 63 Head part 7 Membrane 8 Liquid-tight means 81 Liquid-tight part 811 Base end corner part 82 Inner peripheral surface 10 Injection needle 11 Hub 111 Depression 112 Flange 113 Engagement protrusion 12 Needle tube 121 Lumen 122 Needle 13 Breaking film Member 14 Fixing part 141 Hole 141a Virtual circle 142 Convex part 143 Base end face 144 Hole 15 Projection part 151 Top part 152 Plate piece 153 Groove 154 Needle tip 155 Side hole 156 Lumen 15a Invariable part 15b Decreasing part C Cap S spacer S stopper Engagement part S3 hole

Claims (10)

[Claims] 1. An outer cylinder having a liquid guide portion forming a liquid guide port at a tip, a film for shielding the liquid guide port, and a rupture member for breaking the film to open the liquid guide port. An operating member that includes the membrane rupture member therein and moves the membrane rupture member relative to the liquid guide section to perform an operation of breaking the membrane; A liquid injection device configured to be movable between a first position where the membrane is not broken and a second position where the film is broken. 2. The liquid injection device according to claim 1, wherein the membrane rupture member has a fixing portion fixed to the operation member, and a projection standing upright on the fixing portion to break the membrane. 3. The liquid injection device according to claim 2, wherein the fixing portion has at least one hole through which the liquid passes. 4. The projection has a groove or a hole formed along the longitudinal direction thereof and communicating with the hole.
The liquid injection device according to item 1. 5. The liquid injection device according to claim 2, wherein the protrusion has a sharp end opposite to the fixing portion. 6. The liquid injection device according to claim 1, wherein said film has a thickness of 0.1 to 2.0 mm. 7. The liquid injection device according to claim 1, further comprising a first holding unit that holds the operation member at the first position. 8. The first holding means is detachable from the liquid injection device, and has a spacer portion inserted between the operation member and the outer cylinder to prevent them from approaching. The liquid injection device according to claim 7. 9. The liquid injection device according to claim 1, wherein the operation member holds a needle tube at a distal end thereof. 10. The liquid injection device according to claim 9, wherein the operation member doubles as a hub of the needle tube.