JP2002029954A - Composition for suppressing body smell - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for suppressing body smell capable of suppressing the emission of the body smell and having deodorant effects even on the emitted body smell. SOLUTION: This composition for suppressing the body smell comprises (a) a compound represented by general formula (I) (wherein, R1 and R2 denote each the same or different hydrogen atom or methyl group) or its salt and (b) a plant extracted ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for preventing body odor, which can prevent various odors generated from the human body, or deodorize the generated odor.

[0002]

2. Description of the Related Art Body odors include foot odor, armpit odor, and sweat odor. Many researches have been conducted on these odors, and the main components of the odor have been elucidated and many countermeasures have been found. Have been. These odors are known to be created by "sweat" and "skins resident in the skin".

[0003] Sweat is secreted from the sweat glands.
There are apocrine glands distributed mainly in specific sites and eccrine glands distributed throughout the body.

[0004] Apocrine sweat secreted from the apocrine glands contains a large amount of organic substances (fatty acids and proteins), and the sweat immediately after secretion is odorless. Decomposes into odorous substance. Body odor is mainly caused by this odor, and as the decomposition products, capric acid, caproic acid,
Fatty acids such as isovaleric acid, butyric acid, propionic acid, enanthic acid, pelargonic acid, and isomers of valeric acid such as ethylmethylacetic acid, trimethylacetic acid, and lactic acid are specifically detected, and further, mercaptans, amines, and ammonia. Etc. have been confirmed.

[0005] Ecrine sweat, which is secreted from eccrine glands, is also decomposed and odorized by indigenous bacteria of the skin, but is essentially different from unpleasant odor due to the low content of organic substances.
However, water, which is a main component, plays an indirect role in the generation and emission of body odor, such as promoting the growth of bacteria and increasing the emission of unpleasant odors when the water evaporates.

[0006] Furthermore, foot odor, armpit odor and sweat odor are completely different odors, and one of the odors that are particularly disliked at present is the "aging odor" peculiar to middle-aged and elderly people.

The odor-causing substance is a higher unsaturated fatty acid such as palmitoleic acid (9-hexadenic acid) in sebum, and an unsaturated aldehyde such as octenal and nonenal due to bacteria indigenous to the skin. That's why. 20s,
From the body odor of a person in his thirties, nonenal was hardly detected, but in the age of forties, the frequency and amount of detection of nonenal for both men and women increase. this is,
The amount of higher unsaturated fatty acid palmitoleic acid (9-hexadenic acid), which hardly exists in sebum of young people,
This is attributable to the fact that the amount of lipid peroxide in sebum increases at the same time as in a young person after the age of 40s. The aging odor is an odor that is qualitatively different from the odors such as the axillary odor, foot odor, and sweat odor. However, the discomfort of the odor and the effect on humans are the same for all odors.

[0008] At present, as a means of preventing these body odors,
Suppression of perspiration (antiperspirant that suppresses perspiration that causes odor), inhibition of bacterial growth (antibacterial agent that inhibits the growth of resident bacteria), prevention of sebum oxidation (antioxidant that suppresses sebum oxidation) Oxidizing agents), deodorants with deodorants (deodorants for suppressing generated body odor), fragrances (masking agents for masking body odor with other scents) and the like are used.

[0009]

SUMMARY OF THE INVENTION An object of the present invention is to provide a composition for suppressing body odor, which suppresses the occurrence of the above-mentioned body odor and has a deodorizing effect on the generated body odor.

[0010]

A compound represented by the following general formula (1), which has an antibacterial and antioxidant action to suppress the generation of offensive odor caused by indigenous skin bacteria, which is a main cause of body odor, The present inventors have found that the above-mentioned problems can be solved by combining a plant extract component to enhance the antibacterial activity and deodorize the generated bad odor, and have reached the present invention.

[0011]

Embedded image (Wherein R1 and R2 are the same or different and each represent a hydrogen atom or a methyl group) or a salt thereof.

Examples of the salts of the phosphoric diester represented by the general formula (1) include alkali metal salts such as sodium salt and potassium salt, and alkaline earth metal salts such as calcium salt and magnesium. Particularly, a potassium salt is desirable.

The production method of the phosphoric diester represented by the general formula (1) and a salt thereof is described in JP-A-8-157488. In addition, it is known that it has an anti-inflammatory action, an antioxidant action, a moisturizing action (JP-A-8-12568) and the like, and is a useful and safe compound for the skin.

The amount of the phosphoric diester and its salt used in the composition for suppressing body odor of the present invention is 0.01 to 1%.
% By weight is preferred. If the content is less than 0.01% by weight, the effect is not exhibited. No improvement in the effect is observed even when 1% by weight or more is added.

[0015] The plant extract is prepared by adding a crude drug to a solvent such as water, an organic solvent, or the like by a generally known method for preparing a crude drug extract.
An extract obtained by extracting with an aqueous organic solvent or the like is used as it is or a concentrated extract is used, or the extract is subjected to an adsorption method, for example, a method in which impurities are removed by a purification method using an ion-exchange resin, or by adsorption and desorption using a column. Concentrated extracts can also be used. An extract extracted with water / ethyl acetate can also be used. Further, commercial products of these crude drug extracts can be blended with the composition for suppressing body odor of the present invention.

[0016] For example, Japanese gourd extract, pearl mugwort extract, acacia extract, sage extract, tea extract,
Rosmari extract, fennel extract, thyme extract, aloe extract, ginkgo extract, turmeric extract, oak extract, oulone extract, perilla extract, clove extract, turmeric extract , Vanilla extract, paprika extract, yokunin extract, psycho extract, cucumber extract, suhou extract, curen extract, Jung lab extract, etc. Extract, black tea extract, urong tea extract and the like.

The amount of these plant extracts in the composition for suppressing body odor of the present invention should be appropriately selected according to the type of plant extract to be selected, the relationship with other components, and the like. Although not required, it may be added in a range of generally 0.0001% by weight or more and 10.0% by weight or less, preferably 0.01% by weight or more and 1.0% by weight or less of the composition.

If the amount is less than 0.0001% by weight, it is difficult to sufficiently exhibit the desired deodorizing effect, so that it is not preferable. However, there is a strong tendency that the deodorizing effect commensurate with the increase in the blending amount is not recognized, and depending on the type of the plant extract component to be selected, there may be a problem in the formulation, which is not preferable. In addition, one of the above-mentioned plant extract components can be blended in the composition for suppressing body odor of the present invention, but it can also be blended in combination of two or more. Thus, there is provided a composition for suppressing body odor, which suppresses the generation of body odor and deodorizes the generated body odor.

In the composition for suppressing body odor of the present invention, oils, powders (pigments, dyes), resins, surfactants, tackifiers, preservatives, fragrances, ultraviolet absorbers (organic substances) conventionally used in cosmetics are used. , A humectant, a physiologically active ingredient, a salt, a solvent, an antioxidant, a chelating agent, a neutralizing agent, a pH regulator and the like.

Examples of the oils include those which can be used in cosmetics, such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, octyldodecanol and the like. Fatty acids such as higher alcohols, isostearic acid, undecylenic acid and oleic acid; glycerin, sorbitol, polyhydric alcohols such as ethylene glycol, propylene glycol and polyethylene glycol, myristyl myristate, lauryl Esters such as hexyl acid, decyl oleate, isopropyl myristate, hexyldecyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, liquid paraffin, petrolatum, squalane, etc. The hydrocarbon , Lanolin, reduced lanolin, waxes such as carnauba wax, mink oil, cacao butter, coconut oil, Pa - beam kernel oil, camellia oil, sesame oil, castor oil, Ori - fats and oils of the probe oil.

Examples of other forms of oils include dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, polyether, and the like.
Ter-modified organopolysiloxane, alkyl-modified organopolysiloxane, sugar-modified silicone, glyceryl-modified silicone, amodimethylcone, amino-modified organopolysiloxane, silicone gel, acrylic silicone
And silicone compounds such as trimethylsiloxysilicic acid and silicone RTV rubber.

Examples of the fluorinated oils include fluorocarbons such as perfluorodecalin, alcohols such as perfluoropolyether, fluorinated pitch and fluoroalcohol having a perfluoroalkyl chain. , Perfluoroalkyl phosphate esters such as triethanolamine salts, carboxylic acids having a fluoroalkyl chain, fluoroalkyl modified silicones, fluorine / polyether co-modified silicones, fluorinated silicones Resin.

Examples of the powders include those which can be used in cosmetics, such as nylon beads, silicone powders and the like.
Resin powder such as benz, Teflon (registered trademark), silicone elastomer, yellow iron oxide, red iron oxide, black iron oxide,
Chromium oxide, cobalt oxide, carbon black, ultramarine,
Navy blue, zinc oxide, titanium oxide, zirconium oxide, silicon oxide, aluminum oxide, cerium oxide, titanium mica,
Barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, magnesium silicate, silicon carbide, organic dyes, lakes, fine titanium oxide, fine zinc oxide, fine iron oxide, sericite, mica, talc, plate barium sulfate, etc. Silicone treatment, fluorine compound treatment, silane coupling agent treatment, silane treatment, organic titanate treatment, acylated lysine treatment, fatty acid treatment, metal soap treatment, oil agent treatment, amino acid treatment, wax treatment, metal Surface treatment such as oxide treatment may be performed.

Examples of the surfactant include those which can be used in cosmetics, such as anionic surfactants, cationic surfactants, nonionic surfactants, betaine surfactants and the like. Can be used.

Examples of preservatives include benzoic acid, benzoates, trichlorocarbanide, sorbic acid or salts thereof.

Examples of fragrances include known fragrances such as α
Hydrocarbons such as pinene, limonene and cedrene, aliphatic saturated or unsaturated alcohols such as 1-octene-3-ol and nonanol, myrcenol, tetrahydrolinalol, nerol Cyclic terpene alcohols such as saturated or unsaturated chain terpene alcohols, α-terpineol and bornylmethoxycyclohexanol;
, Sesquiterpene alcohols such as farnesol, aliphatic aldehydes, terpene aldehydes, aromatic aldehydes, iso-i-super (7-acetyl-1,2,2,
3,4,5,6,7,8-octahydro-1,1,6
Aliphatic ketones such as 7-tetramethylnaphthalene), terpene-based cyclic ketones, aliphatic esters, acetates, propionates, enanthates, benzoates, phenylacetates, salicylates, and anthranilates. . The amount of these known fragrances in the body odor suppressant of the present invention should be appropriately selected depending on the kind and purpose of the fragrances to be mixed, and is not particularly limited.

Examples of ultraviolet absorbers include para-amino acid ultraviolet absorbers such as para-aminobenzoic acid, anthranilic acid ultraviolet absorbers such as methyl anthranilate, and salicylic acid ultraviolet absorbers such as octyl salicylate, phenyl salicylate, and homomenthyl salicylate. Isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate,
"4-bis (trimethylsiloxy) methylsilyl-3-
Cinnamic acid-based ultraviolet absorbers such as methylbutyl "-3,4,5-trimethoxycinnamate, 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy Benzophenone ultraviolet absorbers such as benzophenone-5-sulfonic acid and sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate; urocanic acid, ethyl urocanate, 2-phenyl-5-methylbenzoxazo-
, 2- (2'-hydroxy-5'-methylphenyl)
An ultraviolet absorber such as benzotriazole or 4-tert-butyl-4'-methoxydibenzoylmethane can be incorporated into the composition for suppressing body odor of the present invention as a skin external preparation.

Examples of humectants include polyethylene glycol, propylene glycol and dipropylene glycol.
1,3-butylene glycol, hexylene glyco-
, Glycerin, diglycerin, xylitol, maltitol, maltose, D-mannitol, starch syrup, glucose, fructose, lactose, sodium chondroitin sulfate, sodium hyaluronate, sodium adenosine phosphate, sodium lactate, bile acid A humectant such as a salt, pyrrolidone carboxylic acid, glucosamine, cyclodextrin or the like can be incorporated into the composition for suppressing body odor of the present invention as a skin external preparation.

Examples of the antioxidant include butylhydroxyanisole, dibutylhydroxytoluene, tocopherol and the like.

Examples of the solvent include those which can be used for cosmetics, such as purified water, methanol, ethanol, isopropyl alcohol, ether, LPG, and the like.
Volatile silicones, light liquid isoparaffin, alternative chlorofluorocarbons, and the like. It is also possible to use mineral water instead of purified water.

The dosage forms are also aqueous, solubilizing, emulsifying, powder, oil-liquid, gel, ointment, aerosol,
Water-oil two-layer system, water-oil-powder three-layer system, a wide range of dosage forms can be adopted. When the composition for suppressing body odor of the present invention is used as an external preparation for the skin, a known base component or the like is usually added depending on the desired form or dosage form so long as the intended effect of the present invention is not impaired. It can be widely used.

That is, oils such as liquid fats and oils, liquid or solid fats and oils, solid fats and oils, waxes and the like can be incorporated into the composition for suppressing body odor of the present invention as a skin external preparation. Further, an ester oil, a hydrocarbon oil or a silicone can be incorporated into the composition for suppressing body odor of the present invention as an external preparation for skin.

[0033]

Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples. still,
In the examples and comparative examples, parts and% are all based on weight.

Example 1 L-ascorbic acid, DL-α-tocopherol phosphate diester (a compound in which R1 and R2 in formula (1) are methyl groups) potassium salt (hereinafter abbreviated as EPC-KM) 0.2 parts Tea extraction component (green tea liquid: Ichimaru Falcos Co., Ltd.) 1.0 parts Purified water 98.8 parts

Example 2 EPC-KM 0.2 parts Wollong tea extract component (Falco Rex Woolon E: Ichimaru Falcos Co., Ltd.) 1.0 part Purified water 98.8 parts

Comparative Example 1 EPC-KM 0.2 parts Purified water 99.8 parts

Comparative Example 2 Tea extraction component (green tea liquid: Ichimaru Falcos Co., Ltd.) 1.0 part Purified water 99.0 parts

COMPARATIVE EXAMPLE 3 Ingredients for extracting Wurong tea (Falco Rex Wuron E: Ichimaru Falcos Co., Ltd.) 1.0 part Purified water 99.0 parts

To confirm the effects of the present invention, a deodorizing test for ammonia, a deodorizing test for isovaleric acid, and a deodorizing test for propionaldehyde were conducted.

(Deodorizing ability evaluation test) A sample was sealed in a 2 L glass desiccator, and a certain amount of malodor was injected with a micro syringe. The change in the concentration of offensive odors after a certain time is measured using a detector tube. At the same time, as a blank test, the same operation was performed on a desiccator in which no sample was sealed, and the difference in concentration from the blank test was expressed as a percentage and was regarded as a deodorization rate. Deodorization rate = (value of blank test−value of sample inclusion test) × 100 /
The value of the blank test, that is, the larger the value, the greater the deodorizing ability. Ammonia, isovaleric acid, and propionaldehyde were selected as typical odor sources, and 2 μl, 0.2 μl,
0.2 µl was injected to evaluate the bad smell. Specific examples of the composition for suppressing body odor of the present invention are Examples 1 and 2, Comparative Examples are 1 to 3, and evaluation results of Examples and Comparative Examples are shown in Table 1.

[0041]

[Table 1] From the above results, the composition for suppressing body odor of the present invention showed an odor eliminating effect on various odors generated as body odor.

[0042]

As described above, according to the present invention, there is provided a body odor suppressing composition for preventing various malodors generated from the human body or for eliminating the generated malodors.

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Hisayuki Nakayama 9-37, Hirota-cho, Nishinomiya-shi, Hyogo Prefecture Hill House 107 F-term (reference) 4C083 AA111 AA112 AC901 AC902 AD641 AD642 AD661 AD662 CC17 DD23 EE18

Claims (5)

[Claims] 1. a) The following general formula (1): (Wherein, R1 and R2 are the same or different and each represent a hydrogen atom or a methyl group.) A composition for suppressing body odor, comprising: b) a plant extract component; 2. The composition for suppressing body odor according to claim 1, wherein R1 and R2 in the general formula (1) are methyl groups. 3. The compounding amount of a) is 0.01% by weight to 1% by weight.
The composition for suppressing body odor according to claim 1 or 2, wherein 4. The composition for suppressing body odor according to claim 1, wherein the plant extract contains at least one selected from green tea, oolong tea and black tea. 5. The composition for suppressing body odor according to claim 1, wherein the amount of b) is 0.01 to 10% by weight based on a).