JP2002000198A - Composition for royal jelly preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for a royal jelly preparation preventing quality deterioration. SOLUTION: This composition for a royal jelly preparation, obtained by adding collagen containing at least 5% of mucopolysaccharides in an amount of >=10% to dry powder royal jelly. The composition is mixed with an excipient, a lubricant, and so on and then processed by a conventional method into the preparation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition for royal jelly preparations.

[0002]

2. Description of the Related Art As is well known, royal jelly is completely different from ordinary honey, and is stored in a nest in a birdhouse as bait for a queen bee. The taste has a slightly irritating sourness and the appearance is a white paste-like fluid, and the queen bee can lay eggs of its own weight every day by continuing to eat it alone.

[0003] The queen bee is not born as a queen bee, but a normal bee grows into a large queen bee by eating royal jelly. Therefore, many nutrient sources and special effects are contained in royal jelly. It has been speculated that there is a component having the following.

The components of royal jelly known at present include vitamin B group, pantothenic acid, acetylcholine and the like.
It has been reported that there are 0 kinds of vitamins, minerals such as copper, iron, zinc, magnesium, manganese, and cobalt, 24 kinds of amino acids, decenoic acid, parotin, and specific components called R substances. Not everything is known yet. In particular, the presence of proteins with special physiological activities has been recognized as proteins in royal jelly,
For example, a protein having an estimated molecular weight of 48,200 has been reported to have an inhibitory effect on the vasoconstriction of norepinephrine, and it is expected that many bioactive substances will be discovered in a minute.

[0005] In addition, acetylcholine, which is considered to have the highest content in royal jelly among natural objects, acts on the hypothalamus located in the brain stem, which controls vital activities, and often contributes to maintaining the balance of autonomic nerves. It is known.

[0006] From the above, royal jelly is regarded as useful as a dietary supplement and as a natural medicine without side effects to protect human health, and various dosage forms such as jellies, powders, granules, tablets, capsules and the like. It is commercially available at

[0007] On the other hand, it has been observed that royal jelly has extremely poor stability and is easily oxidized by oxygen in the air depending on the storage condition, discoloring to brown and causing deterioration in quality. In addition, when taken, there is a problem that some of the active ingredients contained in the royal jelly, especially proteins and peptides, are degraded by the strong acid in the gastric juice, and the nutritional value is reduced. Therefore, various devices and proposals have been made to solve these problems. Conventionally, in order to ensure the freshness of royal jelly, first, the royal jelly stored in the nest in the birdhouse was collected within 48 hours after secretion,
Keep cool.

By the freeze-drying method, moisture is evaporated without applying heat to form a powder.

[0009] Dosage forms, such as capsules, granules and tablets, which limit contact with oxygen are employed.

[0010] The surface of the tablet is coated with a protein component extracted from wheat gluten meal with alcohol to give gastric acid a strong enteric property.

[0011] Proposals have been made.

[0012]

However, a product simply granulated or encapsulated has a drawback that it cannot withstand long-term storage because oxidation in the air cannot be completely prevented. In addition, when taken, the active ingredient in the royal jelly is decomposed by stomach acid, and its nutritional value is also reduced.

[0013] Tablets whose dosage form is further coated with an enteric coating on its surface are excellent in that they can withstand long-term storage and prevent degradation by gastric juice. However, there are problems in that the coating is performed over multiple layers, the entire film becomes thick, the amount of the main component is limited, and technically delicate techniques are required.

An object of the present invention is to solve the above-mentioned drawbacks of the prior art, and to propose compositions for various royal jelly preparations which have little loss of quality even after long-term storage and little loss of nutritional value even when taken. is there.

[0015]

Means for Solving the Problems To achieve the above object, the present inventors have developed a composition obtained by mixing a collagen dry powder containing 5% or more of mucopolysaccharide with 10% or more of freeze-dried royal jelly. The inventors have found that they are more stable against oxygen in the air than royal jelly alone and have a function of protecting stomach acid from royal jelly components, and have completed the present invention.

According to the present invention, even if any of granule, capsule, and tablet dosage forms are used as the dosage form of the royal jelly preparation, it is possible to prevent long-term storage by preventing oxidation by oxygen in the air, and further take the medicine. It is also to provide a composition in which the components of the royal jelly are not decomposed by stomach acid.

The collagen containing the acidic mucopolysaccharide used in the present invention is extracted from chicken tosaka (cow crown) or bovine umbilical cord, and the contained mucopolysaccharide is a hyaluronic acid having a molecular weight of 1,000,000 or more. It is mainly composed of acids, and contains small amounts of chondroitin sulfate and dermatan sulfate. Collagen obtained from bovine and porcine skin and bone marrow tissue contains almost no acidic mucopolysaccharide and is not suitable for the purpose of the present invention. That is, not only collagen but also acidic mucopolysaccharides, mainly hyaluronic acid, is essential for the present invention.

Although biohyaluronic acid obtained from lactic acid bacteria culture is inexpensive and has high purity, it is not suitable for the present invention because collagen is not present.

The composition of the present invention has an advantage of preventing deterioration of royal jelly and also has an advantage of having a nutritional effect of collagen and hyaluronic acid on the human body. That is, collagen represents one third of the protein in the body, exists as connective tissue of cells, and is the most important protein distributed in skin, tendon, bone, blood vessel wall, teeth, cornea of eyes, etc. .

On the other hand, mucopolysaccharide containing hyaluronic acid is a polymer having a molecular weight of several million which is formed by polymerizing acetylglucosamine and glucuronic acid in pairs, and has a very large hydration power. It is known that it exists in the form of a complex with proteins, particularly collagen, and has an effect of preventing aging by efficiently performing metabolism and function adjustment of the body by maintaining a tissue structure, lubricating action, water retention action, and the like. In fact, according to a recent study by Professor Takahashi of the College of Pharmacy, Nihon University, it has been reported that feeding a diet rich in collagen-mucopolysaccharide significantly suppresses aging of rats. There is much literature on the nutritional effects of collagen and mucopolysaccharides and they are fairly generalized and will not be described much here, but the following points should be mentioned as examples relating to the present invention.

Mucopolysaccharides are constantly being secreted from the stomach wall so that the stomach wall is not digested by the gastric acid that it secretes. If mental stress or the like continues, mucopolysaccharides are not secreted from the stomach wall due to the action of the sympathetic nerve, and the stomach wall is eroded by its own stomach acid, resulting in a so-called gastric ulcer. In other words, mucopolysaccharide has been found to have a protective effect on the stomach wall from strong stomach acid, but this fact is a hint leading to the present invention.

Hereinafter, embodiments of the present invention will be described.

[0023]

Example 1 100K of crude royal jelly (particle size: 150-200 μm) freeze-dried and stored at low temperature
15 kg of collagen powder (containing 6.8% of hyaluronic acid) extracted from cockscomb and lactose 60 K as an excipient
g, 1 kg of a fatty acid ester as a lubricant, 3 liters of ethyl alcohol was added, and the mixture was granulated with a granulator. This is transferred to a drier and dried by blowing air at 30 to 35 ° C. The granules were sieved with a sieve to obtain granules having a granule diameter of 1000 μm. This product was packaged every 1 g to obtain a granular product. The granules were packed in capsules of 100 mg to give capsule products.

[0024]

Example 2 Freeze-dried coarse royal jelly 10
0 kg, 11 kg of collagen powder obtained from a cockscomb, 50 kg of corn starch as an excipient and 2 kg of hardened soybean oil as a lubricant were mixed with ethyl alcohol 3
Liter is added and granulated using a wet granulator. This is sent to a drier and dried by sending air at 40 ° C. or lower. The net was adjusted in a granulator to obtain granules having a granule diameter of 1500 μm. Next, uncoated tablets of 200 mg / piece were produced using a tableting machine.

Next, sugar coating was carried out using 10 kg of a sugar coating liquid consisting of gelatin and granulated sugar, and carnauba wax was further applied to give a sugar-coated tablet containing royal jelly collagen.

[0026]

Example 3 The granules and tablets obtained in Example 1 and Example 2 were subjected to a stability test and an acid resistance test. The stability test was performed as an accelerated test at 37 ° C. and 70% humidity. As a result, the tablet was stable with a water content of 2.0% at 2.1% after 1 month and 2.1% even after 2 months.
Naturally, the granules were not stable because they absorbed moisture immediately when they were naked, but the ones placed in a packaging seal coated on the inside with aluminum wheel-vinyl were as stable as the tablets. The moisture content was stable at 1.5% after 1 month and 1.6% even after 2 months. When the protein content of all samples was measured by the Kjeldahl method, each showed a value of about 16.0% of the total weight, which was consistent within the measurement error at the start of the measurement and after the start. Since this test is an accelerated test, one year to two years
The year was calculated to be stable.

Next, an acid resistance test was carried out using artificial gastric juice described in the General Tests for Pharmacopoeia. For comparison, a granule containing no collagen powder was produced in the same manner as in Example 1 and used for the test. As an index of acid resistance, a change in the content of 10-hydroxy-8-2-decenoic acid in royal jelly was examined. 10 g of a granule sample was added to 100 ml of artificial gastric juice, and the mixture was allowed to stand with gentle stirring at 37 ° C. for 1 hour. The solution was immediately neutralized with an alkali.
A test solution was used. After the test solution was treated with alcohol to remove proteins, hydroxydecenoic acid was separated by thin-layer chromatography, and quantitatively tested using a spectrophotometer and compared. The decenoic acid content before the acid resistance test was 1.5% in the condyle sample and 1.4% in the comparative sample, respectively.
Met. After one hour of acid resistance test, the decenoic acid content was examined and found to be 0.7% in the granule sample.

As can be seen from the results, it is clear that the collagen containing mucopolysaccharide contributes to preventing the active ingredient in the royal jelly from being decomposed by stomach acid and maintaining stable quality for a long period of time. it is obvious.

[0029]

EFFECT OF THE INVENTION It is not decomposed by gastric juice and can reach the intestine while maintaining the active ingredient of royal jelly. In addition, it can be stored while maintaining stable quality for a long time.

Claims (1)

[Claims] 1. A composition for various royal jelly preparations obtained by mixing a dry powder royal jelly and a collagen containing at least 5% of mucopolysaccharide.