JP2008099562A - Skin-beautifying oral composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide food having skin-beautifying effect of improving softness of skin and fixing up skin texture. <P>SOLUTION: The skin-beautifying oral composition contains royal jelly, isoflavone, collagen. The composition further contains one or two kinds of active ingredient selected from a group comprising, coenzyme Q10, hyaluronic acid, vitamins, amino acid and plant extract. For example, the skin-beautifying oral composition is ordinarily applied to an adult (having the body weight of 50 kg) so that intake of the royal jelly per a day is preferably 50-400 mg, intake of the isoflavone per a day is preferably 5-80 mg and intake of the collagen per a day is preferably 50-1,000 mg. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an oral composition for beautifying skin that is excellent in skin beautifying effects and is optimal for improving skin conditions such as skin texture and flexibility.

  In general, it is said that beautiful skin is one that is well-textured, flexible, transparent, and moist. However, these skin conditions are aggravated by aging, seasons, and environmental changes, resulting in an unfavorable appearance.

  In recent years, interest in beauty has increased, and attention has been focused on oral compositions for beautifying skin for improving wrinkles, spots, sagging due to aging, and improving skin conditions such as skin texture and flexibility. As these active ingredients for beautifying skin, various substances such as royal jelly, isoflavone, collagen, coenzyme Q10, hyaluronic acid and various plant extracts have been reported. The present invention relates to a combination of these cosmetic ingredients.

  Royal jelly is a secretion from the pharyngeal gland of honeybees, a substance given to queen bees from the time of larvae. It contains various nutrients such as many vitamins, minerals and amino acids, and is widely used as a nourishing ingredient in health foods. ing. In addition, it is also used in cosmetics, quasi-drugs, etc. in anticipation of beauty effects such as rough skin, acne, whitening, wrinkles and tarmi. Is also shown.

  Isoflavone is 3-phenylchromone and its derivatives, and is contained in many leguminous plants such as soybeans, and is a substance having an estrogen-like action that is a female hormone. Isoflavone is also widely known as a component having an effect of improving osteoporosis and menopause and having a cosmetic effect. For example, as described in Patent Document 3 and Patent Document 4, it is also used as a beauty food.

  Collagen is one of the proteins constituting the dermis, ligaments, cartilage, etc., and these modifications and modifications such as cross-linking are considered to be a cause of skin aging symptoms such as skin elasticity reduction and wrinkle formation. Therefore, many beauty foods for newly supplementing collagen are commercially available.

  In addition, oral compositions in which the above components are combined are also reported as having a cosmetic effect as shown in Patent Document 3 and Patent Document 5.

However, many foods for beauty and skin beautification have been reported with these royal jelly, isoflavone, collagen, or a combination of the two, all of which have sufficient effects on improving skin flexibility and skin texture. Absent.
JP 2004-018446 A JP 2006-8597 A JP 2002-306129 A Japanese Patent Laid-Open No. 11-269066 JP 2001-288073 A

  Therefore, the present inventors diligently studied for the purpose of obtaining a food having an excellent skin beautifying effect that improves skin flexibility and improves skin texture.

  The present inventors have found that an oral composition characterized by containing three kinds of royal jelly, isoflavone, and collagen has a significant skin beautifying effect compared to the use of each alone or a combination of the two. It was. That is, the present invention for achieving the above-mentioned object is an oral composition characterized by containing royal jelly, isoflavone, and collagen.

  INDUSTRIAL APPLICABILITY The present invention can provide an oral composition for beautifying skin capable of obtaining skin beautifying effects such as skin flexibility and improvement of skin texture.

  The royal jelly used in the present invention is a jelly-like substance secreted by female bees and is known to be eaten by the queen bee as the main food. The bee queen bee lays hundreds of thousands of eggs a year and lives nearly ten times as long as worker bees. For this reason, royal jelly is said to be a medicine for longevity, and it is popular as a health food that has the effects of strong, tonic, anti-aging and rejuvenation. Royal jelly contains a good balance of protein, vitamins and minerals that are abundant in pollen. There is no limitation in particular about the royal jelly used for this invention, What is generally distribute | circulating can be used.

  The isoflavone used in the present invention is a compound having an isoflavone skeleton, and examples thereof include daidzein, genistein, etc., those modified in some way such as succinylation and hydroxylation, and analogs and / or metabolites thereof. What is generally distribute | circulated as soybean isoflavone (3 mass% or more as isoflavone content) can also be used.

  Collagen used in the present invention is the main protein of connective tissue of animals, and extracts or hydrolyzes skin, bones and dermis layers of mammals such as cattle and pigs, birds and fish. Soluble collagen and hydrolyzed collagen obtained by the above, or those obtained by further processing such as succinylation. Examples of commercially available products include Marine Matrix (manufactured by Yaizu Suisan Chemical Co., Ltd.), Crotein CAA S. F. (Croda), Promois W (Seiwa Kasei), Atelocollagen SS (Koken).

  When the oral composition for skin beautification of the present invention is applied to, for example, humans, the daily intake of royal jelly in a normal adult (body weight 50 kg) is 10 to 500 mg, preferably 50 mg to 400 mg, particularly preferably 100 to 300 mg. Apply as follows. In addition, it is applied so that the daily intake of isoflavone in a normal adult (body weight 50 kg) is 1 to 100 mg, preferably 5 to 80 mg, particularly preferably 10 to 30 mg. It is applied so that the daily intake of collagen in a normal adult (50 kg) is 1 to 5000 mg, preferably 50 to 1000 mg.

Further, the oral composition for skin beautification according to the present invention includes coenzyme Q10, hyaluronic acid, vitamin A, biotin, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin as long as the effects of the present invention are not impaired as required. Vitamins such as C, vitamin D, vitamin E, vitamin K, vitamin P, folic acid, inositol, pantothenic acid, niacin, nucleic acids, amino acids such as chondroitin sulfate, glucosamine, glycine, alanine, proline, arginine, gluten peptide, casein, Nutritional components such as laminin, mineral components such as calcium, phosphorus, sulfur, potassium, sodium, iron and zinc, plant extracts such as rose extract, carbohydrates such as oligosaccharides, fructose, lactose and new sweeteners, insoluble dietary fiber , Water-soluble dietary fiber, dietary fiber such as chitin and chitosan, Various functional raw materials such as fatty acids such as inic acid, linoleic acid, α-linolenic acid, γ-linolenic acid, araguidonic acid, eicosapentaenoic acid, docosahexaenoic acid, cholesterol, lactic acid bacteria, bifidobacteria, citric acid, polyphenols, etc. Nutritional ingredients can be combined and blended.

  Furthermore, in the oral composition for beautifying skin of the present invention, various components that are usually used can be blended as needed within a range not impairing the effects of the present invention. Examples thereof include an excipient, a binder, a thickener, an emulsifier, a colorant, a fragrance, a food additive, and a seasoning.

  The oral composition for beautifying skin of the present invention is prepared by blending the above-mentioned royal jelly, isoflavone, and collagen as essential components. As an oral composition, if it is taken orally, it can be used without any particular limitation as a specific product, application, property, etc., and it can be used as a liquid, gel or solid food such as an alcoholic beverage, a carbonated beverage, Fruit drinks, coffee drinks, tea drinks, soft drinks such as fruit syrup, lactic acid bacteria drinks such as soups, dressings, jelly, pudding, yogurt and foods, milk drinks and foods, sprinkles, powdered soups and cake mixes , Health foods that are added to frozen desserts such as candy, gum, ice cream, etc., or coated with pills, granules, tablets, gelatin, etc., as appropriate, together with excipients such as dextrin, fragrances and pigments Or processed into dietary supplements.

The present invention will be described in detail below with reference to examples, but the technical scope of the present invention is not limited thereto.
(Example 1)
Tableting and molding were carried out in the usual manner according to the following formulation to prepare tablets for skin care (an average of 300 mg per tablet).
(Unit: mass%)
Soy isoflavone (isoflavone content 40%) 6.0
Collagen (from fish) 8.0
Hyaluronic acid 0.5
Royal Jelly 15.0
Coenzyme Q10 7.0
Vitamin C 5.0
Rose petal extract powder 1.0
Sucrose fatty acid ester 3.0
Maltitol to 100
(Comparative Example 1)
Soft capsules (average of 300 mg per capsule) were prepared in the usual manner according to the following formulation.
<Content liquid>
(Unit: mass%)
Coenzyme Q10 10.0
Hyaluronic acid 1.67
Vitamin E 5.47
Soy isoflavone (isoflavone content 40%) 0.62
Collagen (from fish) 1.67
Beeswax 4.17
Sucrose fatty acid ester 4.17
Wheat germ oil to 100
<Film>
(Unit: mass%)
Gelatin 75.0
Glycerin to 100
(Test method)
Forty-three healthy women (average 54.09 (SD 3.17) years) were treated with the supplement intake group of Example 1 (13 patients), the supplement intake group of Comparative Example 1 (15 patients), and the placebo (no intake) group ( The skin was measured before and after intake for 4 weeks. The measurement was carried out after entering a constant temperature and humidity room with a room temperature of 20 ° C. and a humidity of 50% and acclimatizing to the indoor environment. The measurement site was the same site on the forearm flexion side at 0 weeks and 4 weeks of ingestion. The intake was in accordance with the prescribed amount of each supplement. (The supplement group of Example 1 is 4 tablets each morning and evening, and the supplement intake group of Comparative Example 1 is 2 tablets a day)
1) Skin flexibility The skin flexibility was measured at the measurement site using Cutometer (manufactured by C + K). The degree of skin elongation under a negative pressure load of 300 mbar for 5 seconds was defined as flexibility (mm). Three measurements were taken at the same site, and the average value was taken as the measurement value.
2) Skin surface morphology (texture analysis)
SILFLO (manufactured by Flexico) was used for replicating the skin surface morphology. An analysis sample was prepared by applying SILFLO kneaded with a polymerization agent to a measurement site and peeling off after curing. In the analysis, the depth of skin groove (μm) and the interval of skin groove (μm) were calculated using an image analysis device (Cosmetics Journal, 27, 355, 1993).

  The results are shown in FIGS.

  As is clear from FIGS. 1 to 3, by taking the oral composition according to the present invention, the skin flexibility increased, the skin depth increased, and the skin space decreased.

(Example 2)
Tableting and molding were carried out in the usual manner according to the following formulation to prepare a skin beautifying tablet (average of 250 mg per tablet) and ingested by 4 tablets each morning and evening, a good skin beautifying effect was obtained.
(Unit: mass%)
Soy isoflavone (isoflavone content 40%) 3.0
Royal Jelly 10.0
Collagen (derived from fish) 10.0
Rice extract (containing ceramide) 1.0
Wild Yam (Dioscorea virosa) extract 10.0
Olive water concentrate 4.0
Sucrose fatty acid ester 5.0
Maltitol to 100

(Example 3)
Tableting and molding were carried out in the usual manner according to the following formulation to prepare a skin beautifying tablet (average of 250 mg per tablet) and ingested by 4 tablets each morning and evening. A good skin beautifying effect was obtained.
(Unit: mass%)
Soy isoflavone (isoflavone content 40%) 3.0
Royal Jelly 10.0
Collagen (from fish) 25.0
N-acetylglucosamine 10.0
Glycine 3.0
Proline 2.0
Alanine 1.0
Arginine 3.0
Pearl barley extract 0.5
Sucrose fatty acid ester 5.0
Vitamin B2 0.5
Maltitol to 100

Example 4
Tableting and molding were carried out in the usual manner according to the following formulation to prepare a skin beautifying tablet (average of 250 mg per tablet) and ingested by 4 tablets each morning and evening. A good skin beautifying effect was obtained.
(Unit: mass%)
Soy isoflavone (isoflavone content 40%) 3.0
Royal Jelly 10.0
Collagen (from fish) 25.0
Indigestible dextrin 5.0
Chitosan 1.0
Beat fiber 1.0
Shirako extract (containing DNA) 0.1
Valine 0.2
Leucine 0.2
Isoleucine 0.2
Astaxanthin 0.1
Hyaluronic acid 0.1
Coenzyme Q10 0.1
α-Lipoic acid 0.1
Inositol 0.6
Sake concentrate (containing α-ethyl glucoside) 0.1
Yoriko Extract 0.1
Turmeric extract 0.1
L-carnitine 0.1
Cystine 0.1
Chamomile extract 0.1
Gymnema extract 0.1
Cranberry extract 0.1
β-cryptoxanthin 0.1
Yeast extract 0.1
Coleus Forskori powder 0.1
Chondroitin 0.1
Sazy extract 0.1
Saffron extract 0.1
Hawthorn extract 0.1
Ginger extract 0.1
Ginseng extract 0.1
Ginseng extract 0.1
Theanine 0.1
Sugar beet extract 0.2
Spider web extract 0.1
Cordyceps extract 0.1
Lactic acid bacteria fermentation solution 0.1
Hibiscus extract 0.1
Banaba extract 0.1
Vitamin premix (* 1) 1.0
Multimineral 1.0
Fennel seed extract 0.1
Flax seed extract 0.1
Peppermint extract 0.1
Biotin 0.1
Hihatsu extract 0.1
Fucoidan 0.1
Grape seed extract 0.1
Blueberry extract 0.1
Hesperidin 0.1
β-carotene 0.1
Lychee seed extract 0.1
Raspberry ketone 0.1
Lycopene 0.1
Rooibos tea extract 0.1
Lutein 0.1
Lemongrass extract 0.1
Rosehip extract 0.1
Rose red pedal extract 0.1
Propolis 0.1
Maltitol to 100

* 1: Contains vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, niacin, vitamin B6, folic acid, vitamin B12, pantothenic acid, vitamin C

Comparison results of skin depth after ingestion for 1 month Comparison results of skin gap intervals after ingestion for 1 month Comparison results of skin flexibility after ingestion for 1 month

Claims (2)

An oral composition for beautiful skin, comprising royal jelly, isoflavone, and collagen. The oral composition for beautiful skin according to claim 1, further comprising one or more active ingredients selected from the group consisting of coenzyme Q10, hyaluronic acid, vitamins, amino acids, and plant extracts.

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