JP2001527572A - 実質的に純粋なゾヌリン（ｚｏｎｕｌｉｎ）、哺乳動物密着結合の生理学的な調節因子 - Google Patents
実質的に純粋なゾヌリン（ｚｏｎｕｌｉｎ）、哺乳動物密着結合の生理学的な調節因子Info
- Publication number
- JP2001527572A JP2001527572A JP55036098A JP55036098A JP2001527572A JP 2001527572 A JP2001527572 A JP 2001527572A JP 55036098 A JP55036098 A JP 55036098A JP 55036098 A JP55036098 A JP 55036098A JP 2001527572 A JP2001527572 A JP 2001527572A
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- Prior art keywords
- zonulin
- therapeutic agent
- pharmaceutical composition
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4716—Muscle proteins, e.g. myosin, actin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/844—Stomach; intestine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Electrotherapy Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Particle Accelerators (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/859,931 | 1997-05-21 | ||
| US08/859,931 US5945510A (en) | 1997-05-21 | 1997-05-21 | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
| PCT/US1998/007636 WO1998052415A1 (en) | 1997-05-21 | 1998-04-28 | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005130614A Division JP2005290008A (ja) | 1997-05-21 | 2005-04-27 | 実質的に純粋なゾヌリン（ｚｏｎｕｌｉｎ）、哺乳動物密着結合の生理学的な調節因子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001527572A true JP2001527572A (ja) | 2001-12-25 |
| JP2001527572A5 JP2001527572A5 (enExample) | 2005-12-08 |
Family
ID=25332088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55036098A Ceased JP2001527572A (ja) | 1997-05-21 | 1998-04-28 | 実質的に純粋なゾヌリン（ｚｏｎｕｌｉｎ）、哺乳動物密着結合の生理学的な調節因子 |
| JP2005130614A Withdrawn JP2005290008A (ja) | 1997-05-21 | 2005-04-27 | 実質的に純粋なゾヌリン（ｚｏｎｕｌｉｎ）、哺乳動物密着結合の生理学的な調節因子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005130614A Withdrawn JP2005290008A (ja) | 1997-05-21 | 2005-04-27 | 実質的に純粋なゾヌリン（ｚｏｎｕｌｉｎ）、哺乳動物密着結合の生理学的な調節因子 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5945510A (enExample) |
| EP (1) | EP0982988B1 (enExample) |
| JP (2) | JP2001527572A (enExample) |
| AT (1) | ATE250625T1 (enExample) |
| AU (1) | AU7249198A (enExample) |
| CA (1) | CA2290459A1 (enExample) |
| DE (1) | DE69818450T2 (enExample) |
| DK (1) | DK0982988T3 (enExample) |
| ES (1) | ES2209133T3 (enExample) |
| WO (1) | WO1998052415A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009527468A (ja) * | 2006-02-09 | 2009-07-30 | アルバ セラピューティクス コーポレーション | タイトジャンクション・エフェクター用製剤 |
| WO2016190310A1 (ja) * | 2015-05-26 | 2016-12-01 | 国立大学法人名古屋大学 | タイトジャンクションの緩和剤、該緩和剤を含む薬剤吸収補助剤、及び該緩和剤を含む医薬組成物 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908825A (en) * | 1997-01-09 | 1999-06-01 | University Of Maryland At Baltimore | Dosage composition for nasal delivery and method of use of the same |
| US6458925B1 (en) * | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| ATE252889T1 (de) | 1998-08-19 | 2003-11-15 | Skyepharma Canada Inc | Injizierbare wässerige propofoldispersionen |
| RU2214271C2 (ru) * | 1998-09-14 | 2003-10-20 | Юниверсити Оф Мэриленд, Балтимор | Способ применения zot или зонулина для ингибирования антиген-специфической пролиферации лимфоцитов |
| US6733762B1 (en) | 1998-09-14 | 2004-05-11 | University Of Maryland, Baltimore | Method of using Zot to inhibit lymphocyte proliferation in an antigen-specific manner |
| EP1221975B1 (en) | 1999-10-04 | 2006-12-06 | Nektar Therapeutics Al, Corporation | Polymer stabilized neuropeptides |
| JP2003534287A (ja) * | 2000-05-19 | 2003-11-18 | ユニバーシティ・オブ・メリーランド， ボルティモア | 糖尿病発症を予防または遅延させるためのゾヌリンのペプチドアンタゴニストの使用方法 |
| US7034036B2 (en) * | 2000-10-30 | 2006-04-25 | Pain Therapeutics, Inc. | Inhibitors of ABC drug transporters at the blood-brain barrier |
| EP1384469A1 (de) * | 2002-07-25 | 2004-01-28 | Cognis France S.A. | Verfahren zum Schutz und zur Modulation von Tight Junctions |
| EP1384468A1 (de) * | 2002-07-25 | 2004-01-28 | Cognis France S.A. | Verfahren zum Schutz und zur Modulation von Tight Junctions |
| CA2531491A1 (en) * | 2003-07-15 | 2005-02-03 | University Of Maryland, Baltimore | Agonist polypeptide of receptor for zot and zonulin |
| US20080038843A1 (en) * | 2006-08-11 | 2008-02-14 | University Of Maryland - Baltimore | Method of diagnosing celiac disease |
| TW200637573A (en) * | 2005-01-14 | 2006-11-01 | Univ Maryland | Peptide for delivery of mucosal vaccines |
| TW200716159A (en) * | 2005-06-09 | 2007-05-01 | Univ Maryland | Method of use of antagonists of zonulin to prevent the loss of or to regenerate pancreatic cells |
| US20070239520A1 (en) * | 2006-03-31 | 2007-10-11 | Devin Collins | Motivational apparatus and method of motivation |
| US20090069247A1 (en) * | 2006-10-06 | 2009-03-12 | Blake Paterson | Use of tight junction antagonists to treat inflammatory bowel disease |
| US8034776B2 (en) * | 2006-10-26 | 2011-10-11 | Alba Therapeutics Corporation | Materials and methods for the treatment of celiac disease |
| EP2091551B1 (en) | 2006-11-03 | 2020-01-15 | Alba Therapeutics Corporation | Method of treating asthma |
| US8728491B2 (en) * | 2007-05-07 | 2014-05-20 | Alba Therapeutics Corporation | Transcutaneous delivery of therapeutic agents |
| WO2009006246A1 (en) * | 2007-06-29 | 2009-01-08 | Alea Therapeutics Corp. | Use of tight junction antagonists in the treatment of acute long injury and acute respiratory distress syndrome |
| WO2009015382A2 (en) | 2007-07-26 | 2009-01-29 | Alba Therapeutics Corporation | Novel peptides that enhance tight junction permeability |
| SI3677252T1 (sl) | 2012-03-19 | 2024-02-29 | Cidara Therapeutics, Inc. | Sheme odmerjanja za spojine iz razreda ehinokandinov |
| KR20190121785A (ko) | 2017-02-10 | 2019-10-28 | 이노베이트 바이오파마슈티컬스, 인코포레이티드 | 장 상피의 투과성과 관련된 질환을 치료하기 위한 조성물 및 방법 |
| WO2019165346A1 (en) | 2018-02-23 | 2019-08-29 | Innovate Biopharmaceuticals, Inc. | Compounds and methods for treating tight junction permeability |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665389A (en) * | 1995-05-24 | 1997-09-09 | University Of Maryland At Baltimore | Oral dosage composition for intestinal delivery and method of treating diabetes |
-
1997
- 1997-05-21 US US08/859,931 patent/US5945510A/en not_active Expired - Lifetime
-
1998
- 1998-04-28 CA CA002290459A patent/CA2290459A1/en not_active Abandoned
- 1998-04-28 JP JP55036098A patent/JP2001527572A/ja not_active Ceased
- 1998-04-28 AU AU72491/98A patent/AU7249198A/en not_active Abandoned
- 1998-04-28 WO PCT/US1998/007636 patent/WO1998052415A1/en not_active Ceased
- 1998-04-28 DE DE69818450T patent/DE69818450T2/de not_active Expired - Lifetime
- 1998-04-28 EP EP98919778A patent/EP0982988B1/en not_active Expired - Lifetime
- 1998-04-28 DK DK98919778T patent/DK0982988T3/da active
- 1998-04-28 AT AT98919778T patent/ATE250625T1/de not_active IP Right Cessation
- 1998-04-28 ES ES98919778T patent/ES2209133T3/es not_active Expired - Lifetime
-
2005
- 2005-04-27 JP JP2005130614A patent/JP2005290008A/ja not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009527468A (ja) * | 2006-02-09 | 2009-07-30 | アルバ セラピューティクス コーポレーション | タイトジャンクション・エフェクター用製剤 |
| WO2016190310A1 (ja) * | 2015-05-26 | 2016-12-01 | 国立大学法人名古屋大学 | タイトジャンクションの緩和剤、該緩和剤を含む薬剤吸収補助剤、及び該緩和剤を含む医薬組成物 |
| JPWO2016190310A1 (ja) * | 2015-05-26 | 2018-03-15 | 国立大学法人名古屋大学 | タイトジャンクションの緩和剤、該緩和剤を含む薬剤吸収補助剤、及び該緩和剤を含む医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005290008A (ja) | 2005-10-20 |
| EP0982988B1 (en) | 2003-09-24 |
| EP0982988A1 (en) | 2000-03-08 |
| ATE250625T1 (de) | 2003-10-15 |
| US5945510A (en) | 1999-08-31 |
| WO1998052415A1 (en) | 1998-11-26 |
| AU7249198A (en) | 1998-12-11 |
| DK0982988T3 (da) | 2004-01-19 |
| DE69818450T2 (de) | 2004-07-08 |
| ES2209133T3 (es) | 2004-06-16 |
| DE69818450D1 (de) | 2003-10-30 |
| EP0982988A4 (en) | 2000-04-05 |
| CA2290459A1 (en) | 1998-11-26 |
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