CA2290459A1 - Substantially pure zonulin, a physiological modulator of mammalian tight junctions - Google Patents
Substantially pure zonulin, a physiological modulator of mammalian tight junctions Download PDFInfo
- Publication number
- CA2290459A1 CA2290459A1 CA002290459A CA2290459A CA2290459A1 CA 2290459 A1 CA2290459 A1 CA 2290459A1 CA 002290459 A CA002290459 A CA 002290459A CA 2290459 A CA2290459 A CA 2290459A CA 2290459 A1 CA2290459 A1 CA 2290459A1
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- Prior art keywords
- zonulin
- therapeutic agent
- pharmaceutical composition
- composition
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4716—Muscle proteins, e.g. myosin, actin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/844—Stomach; intestine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Electrotherapy Devices (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Particle Accelerators (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/859,931 | 1997-05-21 | ||
| US08/859,931 US5945510A (en) | 1997-05-21 | 1997-05-21 | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
| PCT/US1998/007636 WO1998052415A1 (en) | 1997-05-21 | 1998-04-28 | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2290459A1 true CA2290459A1 (en) | 1998-11-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002290459A Abandoned CA2290459A1 (en) | 1997-05-21 | 1998-04-28 | Substantially pure zonulin, a physiological modulator of mammalian tight junctions |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5945510A (enExample) |
| EP (1) | EP0982988B1 (enExample) |
| JP (2) | JP2001527572A (enExample) |
| AT (1) | ATE250625T1 (enExample) |
| AU (1) | AU7249198A (enExample) |
| CA (1) | CA2290459A1 (enExample) |
| DE (1) | DE69818450T2 (enExample) |
| DK (1) | DK0982988T3 (enExample) |
| ES (1) | ES2209133T3 (enExample) |
| WO (1) | WO1998052415A1 (enExample) |
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| US5908825A (en) * | 1997-01-09 | 1999-06-01 | University Of Maryland At Baltimore | Dosage composition for nasal delivery and method of use of the same |
| US6458925B1 (en) * | 1998-08-03 | 2002-10-01 | University Of Maryland, Baltimore | Peptide antagonists of zonulin and methods for use of the same |
| AU759641B2 (en) | 1998-08-19 | 2003-04-17 | Skyepharma Canada Inc. | Injectable aqueous dispersions of propofol |
| US6733762B1 (en) | 1998-09-14 | 2004-05-11 | University Of Maryland, Baltimore | Method of using Zot to inhibit lymphocyte proliferation in an antigen-specific manner |
| MXPA01002600A (es) * | 1998-09-14 | 2002-04-08 | Univ Maryland | Metodo de usar zot o zonulina para inhibir la proliferacion linfocito en una manera antigeno-especifico. |
| AU782298B2 (en) | 1999-10-04 | 2005-07-14 | Nektar Therapeutics | Polymer stabilized neuropeptides |
| AU2001249067A1 (en) * | 2000-05-19 | 2001-12-03 | University Of Maryland, Baltimore | Method of use of peptide antagonists of zonulin to prevent or delay the onset ofdiabetes |
| US7034036B2 (en) * | 2000-10-30 | 2006-04-25 | Pain Therapeutics, Inc. | Inhibitors of ABC drug transporters at the blood-brain barrier |
| EP1384469A1 (de) * | 2002-07-25 | 2004-01-28 | Cognis France S.A. | Verfahren zum Schutz und zur Modulation von Tight Junctions |
| EP1384468A1 (de) * | 2002-07-25 | 2004-01-28 | Cognis France S.A. | Verfahren zum Schutz und zur Modulation von Tight Junctions |
| AU2004259705B2 (en) * | 2003-07-15 | 2009-04-23 | University Of Maryland, Baltimore | Agonist polypeptide of receptor for zot and zonulin |
| US20080038843A1 (en) * | 2006-08-11 | 2008-02-14 | University Of Maryland - Baltimore | Method of diagnosing celiac disease |
| TW200637573A (en) * | 2005-01-14 | 2006-11-01 | Univ Maryland | Peptide for delivery of mucosal vaccines |
| AR057058A1 (es) * | 2005-06-09 | 2007-11-14 | Alba Therapeutics Corp | Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas |
| CN103301070A (zh) * | 2006-02-09 | 2013-09-18 | 阿尔巴医疗公司 | 紧密连接效应子的制剂 |
| US20070239520A1 (en) * | 2006-03-31 | 2007-10-11 | Devin Collins | Motivational apparatus and method of motivation |
| US20090069247A1 (en) * | 2006-10-06 | 2009-03-12 | Blake Paterson | Use of tight junction antagonists to treat inflammatory bowel disease |
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| US20100144646A1 (en) * | 2006-11-03 | 2010-06-10 | Blake Paterson | Method of diagnosing and treating asthma |
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| US8198233B2 (en) | 2007-07-26 | 2012-06-12 | Alba Therapeutics Corporation | Synthetic peptides that enhance tight junction permeability |
| WO2013142279A1 (en) | 2012-03-19 | 2013-09-26 | Seachaid Pharmaceuticals, Inc. | Dosing regimens for echinocandin class compounds |
| WO2016190310A1 (ja) * | 2015-05-26 | 2016-12-01 | 国立大学法人名古屋大学 | タイトジャンクションの緩和剤、該緩和剤を含む薬剤吸収補助剤、及び該緩和剤を含む医薬組成物 |
| US20190358288A1 (en) | 2017-02-10 | 2019-11-28 | Innovate Biopharmaceuticals, Inc. | Compositions and methods for treating or preventing environmental enteropathy |
| US11608359B2 (en) | 2018-02-23 | 2023-03-21 | 9 Meters Biopharma, Inc. | Compounds and methods for treating tight junction permeabtility |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665389A (en) * | 1995-05-24 | 1997-09-09 | University Of Maryland At Baltimore | Oral dosage composition for intestinal delivery and method of treating diabetes |
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1997
- 1997-05-21 US US08/859,931 patent/US5945510A/en not_active Expired - Lifetime
-
1998
- 1998-04-28 CA CA002290459A patent/CA2290459A1/en not_active Abandoned
- 1998-04-28 EP EP98919778A patent/EP0982988B1/en not_active Expired - Lifetime
- 1998-04-28 DE DE69818450T patent/DE69818450T2/de not_active Expired - Lifetime
- 1998-04-28 DK DK98919778T patent/DK0982988T3/da active
- 1998-04-28 WO PCT/US1998/007636 patent/WO1998052415A1/en not_active Ceased
- 1998-04-28 AT AT98919778T patent/ATE250625T1/de not_active IP Right Cessation
- 1998-04-28 AU AU72491/98A patent/AU7249198A/en not_active Abandoned
- 1998-04-28 ES ES98919778T patent/ES2209133T3/es not_active Expired - Lifetime
- 1998-04-28 JP JP55036098A patent/JP2001527572A/ja not_active Ceased
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2005
- 2005-04-27 JP JP2005130614A patent/JP2005290008A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU7249198A (en) | 1998-12-11 |
| ATE250625T1 (de) | 2003-10-15 |
| EP0982988B1 (en) | 2003-09-24 |
| JP2005290008A (ja) | 2005-10-20 |
| US5945510A (en) | 1999-08-31 |
| DE69818450D1 (de) | 2003-10-30 |
| DE69818450T2 (de) | 2004-07-08 |
| EP0982988A4 (en) | 2000-04-05 |
| ES2209133T3 (es) | 2004-06-16 |
| WO1998052415A1 (en) | 1998-11-26 |
| JP2001527572A (ja) | 2001-12-25 |
| EP0982988A1 (en) | 2000-03-08 |
| DK0982988T3 (da) | 2004-01-19 |
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| FZDE | Discontinued |