JP2001524829A5 - - Google Patents

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Publication number
JP2001524829A5
JP2001524829A5 JP1998547413A JP54741398A JP2001524829A5 JP 2001524829 A5 JP2001524829 A5 JP 2001524829A5 JP 1998547413 A JP1998547413 A JP 1998547413A JP 54741398 A JP54741398 A JP 54741398A JP 2001524829 A5 JP2001524829 A5 JP 2001524829A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1998547413A
Other languages
English (en)
Japanese (ja)
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JP2001524829A (ja
Filing date
Publication date
Priority claimed from US08/846,247 external-priority patent/US6391594B1/en
Application filed filed Critical
Priority claimed from PCT/US1998/008792 external-priority patent/WO1998049315A2/en
Publication of JP2001524829A publication Critical patent/JP2001524829A/ja
Publication of JP2001524829A5 publication Critical patent/JP2001524829A5/ja
Withdrawn legal-status Critical Current

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JP54741398A 1997-04-30 1998-04-30 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー Withdrawn JP2001524829A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/846,247 1997-04-30
US08/846,247 US6391594B1 (en) 1993-09-20 1997-04-30 Modified modular PKS with retained scaffold
US7691998P 1998-03-05 1998-03-05
US60/076,919 1998-03-05
PCT/US1998/008792 WO1998049315A2 (en) 1997-04-30 1998-04-30 Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008061922A Division JP2008169226A (ja) 1997-04-30 2008-03-11 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー

Publications (2)

Publication Number Publication Date
JP2001524829A JP2001524829A (ja) 2001-12-04
JP2001524829A5 true JP2001524829A5 (OSRAM) 2005-12-02

Family

ID=26758639

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54741398A Withdrawn JP2001524829A (ja) 1997-04-30 1998-04-30 足場としてモジュラー性pks遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー

Country Status (7)

Country Link
EP (1) EP0979286B1 (OSRAM)
JP (1) JP2001524829A (OSRAM)
AU (1) AU732909B2 (OSRAM)
CA (1) CA2288030A1 (OSRAM)
IL (1) IL132590A0 (OSRAM)
NZ (1) NZ500693A (OSRAM)
WO (1) WO1998049315A2 (OSRAM)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
GB9814006D0 (en) 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
US6221641B1 (en) 1998-07-02 2001-04-24 Leland Stanford Junior University Method for making polyketides
NZ510819A (en) 1998-10-02 2004-03-26 Kosan Biosciences Inc Polyketide synthase enzymes and recombinant DNA constructs therefor
CA2347128A1 (en) * 1998-10-28 2000-05-04 Kosan Biosciences, Inc. Library of novel "unnatural" natural products
KR100851418B1 (ko) 1998-11-20 2008-08-08 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
JP2002537762A (ja) 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
EP1754700A3 (en) * 1999-01-27 2007-05-09 Kosan Biosciences, Inc. Synthesis of oligoketides
US6492562B1 (en) * 1999-01-27 2002-12-10 Kosan Biosciences, Inc. Racemic thioesters for production of polyketides
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
EP1153124A2 (en) * 1999-02-09 2001-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
CA2369633A1 (en) * 1999-04-16 2000-10-26 Kosan Biosciences, Inc. A multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
GB9913694D0 (en) * 1999-06-11 1999-08-11 Simper Adrian M DNA manipulation methods and applications for synthetic enzymes
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
AU1231701A (en) 1999-10-25 2001-05-08 Kosan Biosciences, Inc. Production of polyketides
MXPA02004153A (es) 1999-10-27 2002-10-17 Kosan Biosciences Inc Produccion heterologa de policetidos.
ATE356880T1 (de) 1999-10-29 2007-04-15 Kosan Biosciences Inc Rapamycin analoge
US7141660B2 (en) 2000-02-08 2006-11-28 Sinvent As Genes encoding a nystatin polyketide synthase and their manipulation and utility
CA2405958C (en) * 2000-04-13 2011-08-09 Biotica Technology Limited Hybrid glycosylated products and their production and use
EP1278882A4 (en) 2000-05-02 2004-08-18 Kosan Biosciences Inc OVER PRODUCTION INNOVERS FOR THE BIOSYNTHESIS OF POLYKETIDES
US7680601B1 (en) 2000-05-30 2010-03-16 Kosan Biosciences Design of polyketide synthase genes
WO2002099113A1 (en) * 2001-06-01 2002-12-12 Ajinomoto Co., Inc. Macrolide compounds, antifungal agents using the same, macrolide compound-producing bacterium belonging to the genus sorangium and process for producing macrolide compounds using the same
US7189549B2 (en) * 2002-06-14 2007-03-13 Kosan Biosciences, Inc. Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
KR100549690B1 (ko) 2003-10-23 2006-02-07 상하이 지아오통 대학 에프알-008 폴리케타이드 합성에 관여하는 유전자
US7229814B2 (en) 2004-05-05 2007-06-12 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
US20050272166A1 (en) * 2004-05-06 2005-12-08 Li Jin Methods and systems for detection, identification and quantitation of macrolides and their impurities
US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
US8759031B2 (en) 2007-04-12 2014-06-24 Wisconsin Alumni Research Foundation Type I polyketide synthase extender units
US8569023B2 (en) 2008-03-28 2013-10-29 The Regents Of The University Of California Producing dicarboxylic acids using polyketide synthases
CN102014623A (zh) * 2008-04-29 2011-04-13 加利福尼亚大学董事会 使用聚酮化物合酶制备生物燃料
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
GB201312318D0 (en) * 2013-07-09 2013-08-21 Isomerase Therapeutics Ltd Novel methods and compounds
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN112301005B (zh) * 2020-11-09 2023-01-24 浙江大学 一种6-脱氧赤酮酸内酯b合酶复合体3的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
DK0910633T3 (da) 1996-07-05 2010-03-29 Biotica Tech Ltd Hybrid polyketidsyntase I-gen

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