AU732909B2 - Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold - Google Patents

Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold Download PDF

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Publication number
AU732909B2
AU732909B2 AU71722/98A AU7172298A AU732909B2 AU 732909 B2 AU732909 B2 AU 732909B2 AU 71722/98 A AU71722/98 A AU 71722/98A AU 7172298 A AU7172298 A AU 7172298A AU 732909 B2 AU732909 B2 AU 732909B2
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AU
Australia
Prior art keywords
alkyl
pks
polyketide
compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU71722/98A
Other languages
English (en)
Other versions
AU7172298A (en
Inventor
Gary Ashley
Hong Fu
Camilla M. Kao
Chaitan Khosla
Robert Mcdaniel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
Leland Stanford Junior University
Original Assignee
Kosan Biosciences Inc
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/846,247 external-priority patent/US6391594B1/en
Application filed by Kosan Biosciences Inc, Leland Stanford Junior University filed Critical Kosan Biosciences Inc
Publication of AU7172298A publication Critical patent/AU7172298A/en
Assigned to BOARD OF TRUSTEES FOR THE LELAND STANFORD JUNIOR UNIVERSITY, THE, KOSAN BIOSCIENCES, INC. reassignment BOARD OF TRUSTEES FOR THE LELAND STANFORD JUNIOR UNIVERSITY, THE Amend patent request/document other than specification (104) Assignors: BOARD OF REGENTS OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE, KOSAN BIOSCIENCES, INC.
Application granted granted Critical
Publication of AU732909B2 publication Critical patent/AU732909B2/en
Priority to AU57805/01A priority Critical patent/AU769288B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
AU71722/98A 1997-04-30 1998-04-30 Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold Ceased AU732909B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57805/01A AU769288B2 (en) 1997-04-30 2001-08-03 Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/846,247 US6391594B1 (en) 1993-09-20 1997-04-30 Modified modular PKS with retained scaffold
US08/846247 1997-04-30
US7691998P 1998-03-05 1998-03-05
US60/076919 1998-03-05
PCT/US1998/008792 WO1998049315A2 (en) 1997-04-30 1998-04-30 Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU57805/01A Division AU769288B2 (en) 1997-04-30 2001-08-03 Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold

Publications (2)

Publication Number Publication Date
AU7172298A AU7172298A (en) 1998-11-24
AU732909B2 true AU732909B2 (en) 2001-05-03

Family

ID=26758639

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71722/98A Ceased AU732909B2 (en) 1997-04-30 1998-04-30 Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold

Country Status (7)

Country Link
EP (1) EP0979286B1 (OSRAM)
JP (1) JP2001524829A (OSRAM)
AU (1) AU732909B2 (OSRAM)
CA (1) CA2288030A1 (OSRAM)
IL (1) IL132590A0 (OSRAM)
NZ (1) NZ500693A (OSRAM)
WO (1) WO1998049315A2 (OSRAM)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063561A (en) * 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US6066721A (en) * 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6399789B1 (en) 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
GB9814006D0 (en) 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
US6221641B1 (en) 1998-07-02 2001-04-24 Leland Stanford Junior University Method for making polyketides
NZ510819A (en) 1998-10-02 2004-03-26 Kosan Biosciences Inc Polyketide synthase enzymes and recombinant DNA constructs therefor
CA2347128A1 (en) * 1998-10-28 2000-05-04 Kosan Biosciences, Inc. Library of novel "unnatural" natural products
KR100851418B1 (ko) 1998-11-20 2008-08-08 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
JP2002537762A (ja) 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
EP1754700A3 (en) * 1999-01-27 2007-05-09 Kosan Biosciences, Inc. Synthesis of oligoketides
US6492562B1 (en) * 1999-01-27 2002-12-10 Kosan Biosciences, Inc. Racemic thioesters for production of polyketides
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
EP1153124A2 (en) * 1999-02-09 2001-11-14 The Board Of Trustees Of The Leland Stanford Junior University Methods to mediate polyketide synthase module effectiveness
CA2369633A1 (en) * 1999-04-16 2000-10-26 Kosan Biosciences, Inc. A multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
GB9913694D0 (en) * 1999-06-11 1999-08-11 Simper Adrian M DNA manipulation methods and applications for synthetic enzymes
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
AU1231701A (en) 1999-10-25 2001-05-08 Kosan Biosciences, Inc. Production of polyketides
MXPA02004153A (es) 1999-10-27 2002-10-17 Kosan Biosciences Inc Produccion heterologa de policetidos.
ATE356880T1 (de) 1999-10-29 2007-04-15 Kosan Biosciences Inc Rapamycin analoge
US7141660B2 (en) 2000-02-08 2006-11-28 Sinvent As Genes encoding a nystatin polyketide synthase and their manipulation and utility
CA2405958C (en) * 2000-04-13 2011-08-09 Biotica Technology Limited Hybrid glycosylated products and their production and use
EP1278882A4 (en) 2000-05-02 2004-08-18 Kosan Biosciences Inc OVER PRODUCTION INNOVERS FOR THE BIOSYNTHESIS OF POLYKETIDES
US7680601B1 (en) 2000-05-30 2010-03-16 Kosan Biosciences Design of polyketide synthase genes
WO2002099113A1 (en) * 2001-06-01 2002-12-12 Ajinomoto Co., Inc. Macrolide compounds, antifungal agents using the same, macrolide compound-producing bacterium belonging to the genus sorangium and process for producing macrolide compounds using the same
US7189549B2 (en) * 2002-06-14 2007-03-13 Kosan Biosciences, Inc. Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
KR100549690B1 (ko) 2003-10-23 2006-02-07 상하이 지아오통 대학 에프알-008 폴리케타이드 합성에 관여하는 유전자
US7229814B2 (en) 2004-05-05 2007-06-12 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
US20050272166A1 (en) * 2004-05-06 2005-12-08 Li Jin Methods and systems for detection, identification and quantitation of macrolides and their impurities
US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
US8759031B2 (en) 2007-04-12 2014-06-24 Wisconsin Alumni Research Foundation Type I polyketide synthase extender units
US8569023B2 (en) 2008-03-28 2013-10-29 The Regents Of The University Of California Producing dicarboxylic acids using polyketide synthases
CN102014623A (zh) * 2008-04-29 2011-04-13 加利福尼亚大学董事会 使用聚酮化物合酶制备生物燃料
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
GB201312318D0 (en) * 2013-07-09 2013-08-21 Isomerase Therapeutics Ltd Novel methods and compounds
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
CN112301005B (zh) * 2020-11-09 2023-01-24 浙江大学 一种6-脱氧赤酮酸内酯b合酶复合体3的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040968A1 (en) * 1995-06-07 1996-12-19 The Leland Stanford Junior University Recombinant production of novel polyketides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0910633T3 (da) 1996-07-05 2010-03-29 Biotica Tech Ltd Hybrid polyketidsyntase I-gen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040968A1 (en) * 1995-06-07 1996-12-19 The Leland Stanford Junior University Recombinant production of novel polyketides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCIENCE 22 JULY 1994, 265(5171), PAGES 509-12 *

Also Published As

Publication number Publication date
NZ500693A (en) 2004-01-30
AU7172298A (en) 1998-11-24
JP2001524829A (ja) 2001-12-04
EP0979286A2 (en) 2000-02-16
CA2288030A1 (en) 1998-11-05
IL132590A0 (en) 2001-03-19
WO1998049315A3 (en) 1999-01-14
WO1998049315A2 (en) 1998-11-05
EP0979286B1 (en) 2014-01-29

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TC Change of applicant's name (sec. 104)

Free format text: KOSAN BIOSCIENCES, INC.; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

FGA Letters patent sealed or granted (standard patent)