JP2001521510A - ガンおよびaidsの処置のための活性化ヨード誘導体 - Google Patents
ガンおよびaidsの処置のための活性化ヨード誘導体Info
- Publication number
- JP2001521510A JP2001521510A JP54254798A JP54254798A JP2001521510A JP 2001521510 A JP2001521510 A JP 2001521510A JP 54254798 A JP54254798 A JP 54254798A JP 54254798 A JP54254798 A JP 54254798A JP 2001521510 A JP2001521510 A JP 2001521510A
- Authority
- JP
- Japan
- Prior art keywords
- group
- iodo
- compounds
- nitro
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
- C07D213/87—Hydrazides; Thio or imino analogues thereof in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.以下の構造式で表される、腫瘍性疾患またはウィルス疾患の処置に使用する ための化合物: ここで、Yは、脂肪族基、芳香族基、ヘテロ環式基、炭水化物基からなる群より 選択されたキレート基であり、YとNとは一緒になってヘテロ環式環を形成し、R1 およびR3は同一かあるいは異なっており、そしてH、NO2またはNH2であり、R2はN O2またはNH2であり、そしてR2がNH2のとき、R1およびR3はHである。 2.以下の構造式で表される、腫瘍性疾患またはウィルス疾患の処置に使用する ための化合物: ここで、R4は、-CH2CH=CH2、-CH2C≡CH、-NHC≡CH、-NHCH=CH2、OH -(CH2)aN(R5)(R6)(ここで、a=1あるいは2であり、そしてR5およびR6は、H、また は低級アルキルである)、 (ここで、R7はHまたはCF3である)(ここで、Xは、H、-NO2、-COOCH2CH3、あるいは-CH3であり、そしてR8はHまた はCH3である) である。 3.以下の式で表される、請求項1に記載の化合物: ここで、Zは、である。 4.以下の式で表される、請求項1に記載の化合物: 5.以下の式で表される、請求項1に記載の化合物: 6.以下の式で表される、請求項1に記載の化合物: 7.請求項1から6のいずれかに記載の化合物ならびに薬学的に受容可能な賦形剤 を含有する薬学的組成物。 8.腫瘍性疾患またはウィルス疾患の処置に使用するための、請求項7に記載の薬 学的組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4336097P | 1997-04-10 | 1997-04-10 | |
US60/043,360 | 1997-04-10 | ||
PCT/IB1998/000768 WO1998045253A1 (en) | 1997-04-10 | 1998-04-10 | Activated iododerivatives for the treatment of cancer and aids |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001521510A true JP2001521510A (ja) | 2001-11-06 |
JP2001521510A5 JP2001521510A5 (ja) | 2004-08-19 |
JP4001636B2 JP4001636B2 (ja) | 2007-10-31 |
Family
ID=21926774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54254798A Expired - Fee Related JP4001636B2 (ja) | 1997-04-10 | 1998-04-10 | ガンおよびaidsの処置のための活性化ヨード誘導体 |
Country Status (8)
Country | Link |
---|---|
US (1) | US6225323B1 (ja) |
EP (1) | EP0973727B8 (ja) |
JP (1) | JP4001636B2 (ja) |
AT (1) | ATE307797T1 (ja) |
AU (1) | AU7074298A (ja) |
CA (1) | CA2286186A1 (ja) |
DE (1) | DE69832051T2 (ja) |
WO (1) | WO1998045253A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
TWI284639B (en) * | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
WO2002089745A2 (en) * | 2001-05-10 | 2002-11-14 | Cytovia, Inc. | Substituted n'-(arylcarbonyl)-benzhydrazides, n'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US20040018983A1 (en) * | 2001-12-21 | 2004-01-29 | Achillion Pharmaceuticals, Inc. | Antifungal compositions |
US7101676B2 (en) * | 2002-01-11 | 2006-09-05 | Douglas Buechter | Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA |
US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
EP1655291B1 (en) * | 2003-08-12 | 2016-08-03 | Shionogi & Co., Ltd. | Compounds having thrombopoietin receptor agonism |
JP5177429B2 (ja) | 2005-07-18 | 2013-04-03 | バイパー サイエンシズ,インコーポレイティド | 癌の治療 |
CN101522609A (zh) | 2006-09-05 | 2009-09-02 | 彼帕科学公司 | 癌症的治疗 |
NZ579098A (en) * | 2007-01-16 | 2012-07-27 | Bipar Sciences Inc | Formulations for cancer treatment |
GB0905525D0 (en) * | 2009-03-31 | 2009-05-13 | Univ Leiden | Compounds and uses |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2637947C2 (de) * | 1976-08-24 | 1985-09-19 | Bayer Ag, 5090 Leverkusen | Tetrafluor-1,3-benzodioxanyl-benzoylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Insektizide |
JPS649978A (en) * | 1987-07-02 | 1989-01-13 | Shionogi & Co | Perfluoroalkylisoxazole derivative |
GB9016581D0 (en) * | 1990-07-27 | 1990-09-12 | Ici Plc | Fungicides |
US5877185A (en) * | 1991-10-22 | 1999-03-02 | Octamer, Inc. | Synergistic compositions useful as anti-tumor agents |
US5516941A (en) | 1991-10-22 | 1996-05-14 | Octamer, Inc. | Specific inactivators of "retroviral" (asymmetric) zinc fingers |
US5464871A (en) | 1993-05-12 | 1995-11-07 | Octamer, Inc. | Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents |
-
1998
- 1998-04-10 AT AT98917555T patent/ATE307797T1/de not_active IP Right Cessation
- 1998-04-10 US US09/125,173 patent/US6225323B1/en not_active Expired - Fee Related
- 1998-04-10 CA CA002286186A patent/CA2286186A1/en not_active Abandoned
- 1998-04-10 EP EP98917555A patent/EP0973727B8/en not_active Expired - Lifetime
- 1998-04-10 WO PCT/IB1998/000768 patent/WO1998045253A1/en active IP Right Grant
- 1998-04-10 AU AU70742/98A patent/AU7074298A/en not_active Abandoned
- 1998-04-10 JP JP54254798A patent/JP4001636B2/ja not_active Expired - Fee Related
- 1998-04-10 DE DE69832051T patent/DE69832051T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4001636B2 (ja) | 2007-10-31 |
CA2286186A1 (en) | 1998-10-15 |
EP0973727B1 (en) | 2005-10-26 |
ATE307797T1 (de) | 2005-11-15 |
AU7074298A (en) | 1998-10-30 |
US6225323B1 (en) | 2001-05-01 |
DE69832051D1 (de) | 2005-12-01 |
WO1998045253A1 (en) | 1998-10-15 |
EP0973727A2 (en) | 2000-01-26 |
EP0973727B8 (en) | 2006-01-18 |
DE69832051T2 (de) | 2006-04-27 |
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