JP2001520634A5 - - Google Patents

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Publication number
JP2001520634A5
JP2001520634A5 JP1997509507A JP50950797A JP2001520634A5 JP 2001520634 A5 JP2001520634 A5 JP 2001520634A5 JP 1997509507 A JP1997509507 A JP 1997509507A JP 50950797 A JP50950797 A JP 50950797A JP 2001520634 A5 JP2001520634 A5 JP 2001520634A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997509507A
Other languages
English (en)
Japanese (ja)
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JP2001520634A (ja
JP3868494B2 (ja
Filing date
Publication date
Priority claimed from US08/514,451 external-priority patent/US5837809A/en
Priority claimed from US08/553,058 external-priority patent/US5821219A/en
Application filed filed Critical
Publication of JP2001520634A publication Critical patent/JP2001520634A/ja
Publication of JP2001520634A5 publication Critical patent/JP2001520634A5/ja
Application granted granted Critical
Publication of JP3868494B2 publication Critical patent/JP3868494B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP50950797A 1995-08-11 1996-08-12 オピオイドアンタゴニストおよびそれらの使用方法 Expired - Lifetime JP3868494B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/514,451 1995-08-11
US08/514,451 US5837809A (en) 1995-08-11 1995-08-11 Mammalian opioid receptor ligand and uses
US08/553,058 US5821219A (en) 1995-08-11 1995-11-03 Opioid antagonists and methods of their use
US08/553,058 1995-11-03
PCT/US1996/013305 WO1997007212A1 (en) 1995-08-11 1996-08-12 Opioid antagonists and methods of their use

Publications (3)

Publication Number Publication Date
JP2001520634A JP2001520634A (ja) 2001-10-30
JP2001520634A5 true JP2001520634A5 (https=) 2004-09-09
JP3868494B2 JP3868494B2 (ja) 2007-01-17

Family

ID=27058205

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50950797A Expired - Lifetime JP3868494B2 (ja) 1995-08-11 1996-08-12 オピオイドアンタゴニストおよびそれらの使用方法

Country Status (8)

Country Link
US (1) US5821219A (https=)
EP (1) EP0843726B1 (https=)
JP (1) JP3868494B2 (https=)
AT (1) ATE323160T1 (https=)
AU (1) AU728001B2 (https=)
CA (1) CA2229126A1 (https=)
DE (1) DE69636037D1 (https=)
WO (1) WO1997007212A1 (https=)

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CA2206192A1 (en) 1996-06-13 1997-12-13 F. Hoffmann-La Roche Ag Modulation of lc132 (opioid-like) receptor function
EP0813065A3 (en) * 1996-06-13 1998-07-22 F. Hoffmann-La Roche Ag Modulation of LC132 (opioid-like) receptor function
AU8333998A (en) * 1997-07-15 1999-02-10 Novo Nordisk A/S New use of nociceptin
WO1999003880A1 (en) * 1997-07-15 1999-01-28 Novo Nordisk A/S Nociceptin analogues
US5929035A (en) * 1998-04-14 1999-07-27 Regents Of The University Of Michigan Methods of treating intestinal disorders
GB9815618D0 (en) * 1998-07-18 1998-09-16 Univ Manchester Treatment of dyskinesia
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
US6582457B2 (en) * 2001-02-15 2003-06-24 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering
US6849449B2 (en) * 2001-03-01 2005-02-01 Regents Of The University Of Michigan Orphanin FQ receptor nucleic acids
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター1アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
WO2003030828A2 (en) * 2001-10-09 2003-04-17 Synvax, Inc. Nociceptin-based analgesics
WO2003093294A2 (en) * 2002-04-29 2003-11-13 Euro-Celtique S.A. Conformationally constrained peptides that bind the orl-1 receptor
AU2003257111A1 (en) * 2002-08-02 2004-02-23 Incyte Corporation Extracellular messengers
JP4712384B2 (ja) 2002-09-09 2011-06-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Orl−1受容体介在障害の治療に有用なヒドロキシアルキル置換1,3,8−トリアザスピロ[4.5]デカン−4−オン誘導体
CA2811272C (en) 2003-04-08 2016-12-20 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
US7173010B2 (en) * 2003-05-19 2007-02-06 Regents Of The University Of Michigan Orphanin FQ receptor
ES2714198T3 (es) 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
WO2006130416A2 (en) 2005-06-02 2006-12-07 Janssen Pharmaceutica, N.V. Novel 3-spirocyclic indolyl derivatives useful as orl-1 receptor modulators
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
US8703948B2 (en) 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
EP2565195B1 (en) 2007-03-29 2015-05-06 Wyeth LLC Peripheral opioid receptor and antagonists and uses thereof
PL2137191T3 (pl) 2007-03-29 2016-12-30 Antagoniści obwodowego receptora opioidowego i ich zastosowania
JP2010522756A (ja) 2007-03-29 2010-07-08 プロジェニックス ファーマシューティカルズ,インコーポレーテッド 結晶形およびその使用
CA2683598C (en) 2007-04-09 2015-11-17 Janssen Pharmaceutica Nv 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
WO2008142454A1 (en) 2007-05-22 2008-11-27 Prosidion Limited Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders
WO2009030962A1 (en) 2007-09-07 2009-03-12 Prosidion Limited Bicyclic aryl and heteroaryl receptor modulators
AU2008349873B2 (en) 2008-02-06 2014-02-13 Progenics Pharmaceuticals, Inc. Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
CA2719134C (en) 2008-03-21 2015-06-30 The University Of Chicago Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
RU2492482C1 (ru) * 2012-10-08 2013-09-10 Игорь Петрович Папышев Способ диагностики причины смерти от интоксикации наркотическими веществами группы опиатов

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US4582820A (en) * 1982-12-23 1986-04-15 Research Corporation Orally administered biologically active peptides and proteins
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5017689A (en) * 1989-07-06 1991-05-21 Arizona Technology Development Corporation Dynorphin analogs specific for kappa opioid receptors
US5512578A (en) * 1992-09-21 1996-04-30 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists
US6235496B1 (en) * 1993-03-08 2001-05-22 Advanced Research & Technology Institute Nucleic acid encoding mammalian mu opioid receptor

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