JP2001517657A5 - - Google Patents
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- Publication number
- JP2001517657A5 JP2001517657A5 JP2000512815A JP2000512815A JP2001517657A5 JP 2001517657 A5 JP2001517657 A5 JP 2001517657A5 JP 2000512815 A JP2000512815 A JP 2000512815A JP 2000512815 A JP2000512815 A JP 2000512815A JP 2001517657 A5 JP2001517657 A5 JP 2001517657A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alk
- carbon atoms
- hydrogen atom
- saturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atoms Chemical group C* 0.000 description 18
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
- 125000004433 nitrogen atoms Chemical group N* 0.000 description 8
- 125000004430 oxygen atoms Chemical group O* 0.000 description 8
- 125000004434 sulfur atoms Chemical group 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 6
- 125000005842 heteroatoms Chemical group 0.000 description 6
- -1 unsaturated acyclic hydrocarbon Chemical class 0.000 description 6
- 239000004215 Carbon black (E152) Substances 0.000 description 4
- 229910003827 NRaRb Inorganic materials 0.000 description 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 150000008574 D-amino acids Chemical class 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000004423 acyloxy group Chemical group 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000003282 alkyl amino group Chemical group 0.000 description 2
- 125000004414 alkyl thio group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 2
- 125000002837 carbocyclic group Chemical group 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 description 2
- 125000004663 dialkyl amino group Chemical group 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 125000002950 monocyclic group Chemical group 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9711859A FR2768734B1 (fr) | 1997-09-24 | 1997-09-24 | Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| FR97/11859 | 1997-09-24 | ||
| PCT/FR1998/002039 WO1999015507A1 (fr) | 1997-09-24 | 1998-09-23 | Derives d'hydrazono-benzazulene, compositions pharmaceutiques et intermediaires |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001517657A JP2001517657A (ja) | 2001-10-09 |
| JP2001517657A5 true JP2001517657A5 (ru) | 2006-01-05 |
| JP4493839B2 JP4493839B2 (ja) | 2010-06-30 |
Family
ID=9511409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000512815A Expired - Lifetime JP4493839B2 (ja) | 1997-09-24 | 1998-09-23 | ヒドラゾノ−ベンゾアズレン誘導体、製薬組成物及び中間体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6277845B1 (ru) |
| EP (1) | EP1017681B1 (ru) |
| JP (1) | JP4493839B2 (ru) |
| AT (1) | ATE236885T1 (ru) |
| AU (1) | AU9270598A (ru) |
| DE (1) | DE69813263T2 (ru) |
| DK (1) | DK1017681T3 (ru) |
| ES (1) | ES2192789T3 (ru) |
| FR (1) | FR2768734B1 (ru) |
| PT (1) | PT1017681E (ru) |
| WO (1) | WO1999015507A1 (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2768736B1 (fr) * | 1997-09-24 | 2000-05-26 | Roussel Uclaf | Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| US6514964B1 (en) | 1999-09-27 | 2003-02-04 | Amgen Inc. | Fused cycloheptane and fused azacycloheptane compounds and their methods of use |
| RU2316337C2 (ru) | 2001-04-24 | 2008-02-10 | Мерк Патент Гмбх | КОМБИНИРОВАННАЯ ТЕРАПИЯ, ИСПОЛЬЗУЮЩАЯ АНТИАНГИОГЕННЫЕ СРЕДСТВА И TNF-α |
| EP2338518A1 (en) | 2006-01-18 | 2011-06-29 | Merck Patent GmbH | Specific therapy using integrin ligands for treating cancer |
| BRPI0806596A2 (pt) | 2007-01-18 | 2013-07-23 | Merck Patent Ges Mit Berchraenkter Haftung | medicamento e terapia especÍfica usando-se ligantes de integrina para o tratamento de cÂncer |
| WO2010068371A2 (en) * | 2008-12-11 | 2010-06-17 | University Of Georgia Research Foundation, Inc. | Preparation of alkenes by mild thermolysis of sulfoxides |
| MX2011012491A (es) | 2009-05-25 | 2011-12-14 | Merck Patent Gmbh | Administracion continua de cilengitida en tratamientos contra el cancer. |
| BR112016027778A2 (pt) | 2014-05-30 | 2017-08-15 | Pfizer | Usos de derivados de carbonitrila, sua combinação e sua composição farmacêutica |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0777657A1 (en) * | 1994-08-22 | 1997-06-11 | Smithkline Beecham Corporation | Bicyclic compounds |
| FR2731217B1 (fr) * | 1995-03-03 | 1997-06-13 | Roussel Uclaf | Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires |
| DK0888292T3 (da) * | 1996-03-20 | 2002-02-18 | Genentech Inc | Tricykliske forbindelser med virkning over for integriner, især alphavbeta3 integriner, fremgangsmåde til deres fremstilling, mellemprodukter deraf, deres anvendelse som lægemidler og farmaceutiske præparater med indhold deraf |
| DE19629817A1 (de) * | 1996-07-24 | 1998-01-29 | Hoechst Ag | Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten |
-
1997
- 1997-09-24 FR FR9711859A patent/FR2768734B1/fr not_active Expired - Lifetime
-
1998
- 1998-09-23 PT PT98945363T patent/PT1017681E/pt unknown
- 1998-09-23 EP EP98945363A patent/EP1017681B1/fr not_active Expired - Lifetime
- 1998-09-23 WO PCT/FR1998/002039 patent/WO1999015507A1/fr active IP Right Grant
- 1998-09-23 ES ES98945363T patent/ES2192789T3/es not_active Expired - Lifetime
- 1998-09-23 AT AT98945363T patent/ATE236885T1/de not_active IP Right Cessation
- 1998-09-23 US US09/509,263 patent/US6277845B1/en not_active Expired - Lifetime
- 1998-09-23 DK DK98945363T patent/DK1017681T3/da active
- 1998-09-23 JP JP2000512815A patent/JP4493839B2/ja not_active Expired - Lifetime
- 1998-09-23 AU AU92705/98A patent/AU9270598A/en not_active Abandoned
- 1998-09-23 DE DE69813263T patent/DE69813263T2/de not_active Expired - Lifetime
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