JP2001516591A - 質量分析法による核酸の分析方法 - Google Patents

質量分析法による核酸の分析方法

Info

Publication number
JP2001516591A
JP2001516591A JP2000511900A JP2000511900A JP2001516591A JP 2001516591 A JP2001516591 A JP 2001516591A JP 2000511900 A JP2000511900 A JP 2000511900A JP 2000511900 A JP2000511900 A JP 2000511900A JP 2001516591 A JP2001516591 A JP 2001516591A
Authority
JP
Japan
Prior art keywords
nucleic acid
mass
analysis method
label
labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000511900A
Other languages
English (en)
Japanese (ja)
Inventor
シュミット、グンテル
ヒュージン トムソン、アンドリュー
Original Assignee
ブラックス グループ リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719638.0A external-priority patent/GB9719638D0/en
Priority claimed from GBGB9725630.9A external-priority patent/GB9725630D0/en
Application filed by ブラックス グループ リミテッド filed Critical ブラックス グループ リミテッド
Publication of JP2001516591A publication Critical patent/JP2001516591A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000511900A 1997-09-15 1998-09-15 質量分析法による核酸の分析方法 Pending JP2001516591A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9719638.0A GB9719638D0 (en) 1997-09-15 1997-09-15 High throughput analysis of sanger dna ladders by tandem mass spectrometry
GB9719638.0 1997-09-15
GB9725630.9 1997-12-03
GBGB9725630.9A GB9725630D0 (en) 1997-12-03 1997-12-03 Charecterising nucleic acid
PCT/GB1998/002789 WO1999014362A1 (fr) 1997-09-15 1998-09-15 Caracterisation d'acide nucleique par spectrometrie de masse

Publications (1)

Publication Number Publication Date
JP2001516591A true JP2001516591A (ja) 2001-10-02

Family

ID=26312254

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000511900A Pending JP2001516591A (ja) 1997-09-15 1998-09-15 質量分析法による核酸の分析方法

Country Status (6)

Country Link
EP (1) EP1015632A1 (fr)
JP (1) JP2001516591A (fr)
AU (1) AU746443B2 (fr)
CA (1) CA2303790A1 (fr)
NZ (1) NZ503289A (fr)
WO (1) WO1999014362A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19824280B4 (de) * 1998-05-29 2004-08-19 Bruker Daltonik Gmbh Mutationsanalyse mittels Massenspektrometrie
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
WO2001096607A2 (fr) * 2000-06-13 2001-12-20 The Trustees Of Boston University Utilisation d'analogues nucleotidiques dans l'analyse de melanges d'oligonucleotides et le sequençage hautement multiplexe d'acides nucleiques
JP4290003B2 (ja) 2001-09-14 2009-07-01 エレクトロフォレティクス リミテッド 質量標識体
ATE515702T1 (de) 2003-01-30 2011-07-15 Life Technologies Corp Verfahren, mixturen, kits und zusammensetzungen bezüglich der analytbestimmung
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1262564A3 (fr) * 1993-01-07 2004-03-31 Sequenom, Inc. Séquençage d'adn par spectrométrie de masse
WO1994021822A1 (fr) * 1993-03-19 1994-09-29 Sequenom, Inc. Sequençage de l'adn au moyen de la spectrometrie de masse par degradation a l'exonuclease
GB9504598D0 (en) * 1995-03-03 1995-04-26 Imp Cancer Res Tech Method of nucleic acid analysis
CN1163619C (zh) * 1996-01-23 2004-08-25 佳根基因组学公司 测定核酸分子序列的方法和组合物
EP0886681A1 (fr) * 1996-03-04 1998-12-30 Genetrace Systems, Inc. Methodes de criblage des acides nucleiques par spectrometrie de masse
WO1997037041A2 (fr) * 1996-03-18 1997-10-09 Sequenom, Inc. Sequençage d'adn par spectrometrie de masse
US5803916A (en) * 1996-03-19 1998-09-08 Vital-Tech Ltd. Body and joints massage device
GB9620769D0 (en) * 1996-10-04 1996-11-20 Brax Genomics Ltd Nucleic acid sequencing
WO1998026095A1 (fr) * 1996-12-10 1998-06-18 Genetrace Systems Inc. Molecules d'etiquetage massique, non volatiles et liberables
ATE374836T1 (de) * 1997-01-15 2007-10-15 Xzillion Gmbh & Co Kg Massenmarkierte hybridisierungssonden
AU5974498A (en) * 1997-02-18 1998-09-09 Kinetic Limited Control arrangement for vehicle suspension system

Also Published As

Publication number Publication date
CA2303790A1 (fr) 1999-03-25
AU746443B2 (en) 2002-05-02
NZ503289A (en) 2002-11-26
AU9088798A (en) 1999-04-05
EP1015632A1 (fr) 2000-07-05
WO1999014362A1 (fr) 1999-03-25

Similar Documents

Publication Publication Date Title
US9051608B2 (en) Detection and quantification of biomolecules using mass spectrometry
US8133701B2 (en) Detection and quantification of biomolecules using mass spectrometry
US6750022B2 (en) Mutation analysis by PCR and mass spectrometry
US6270976B1 (en) Characterizing nucleic acid by mass spectrometry
Murray DNA sequencing by mass spectrometry
EP1400599B1 (fr) Sondes d'hybridation couplées à des marqueurs de masse
US6428955B1 (en) DNA diagnostics based on mass spectrometry
EP2099934B1 (fr) Détection et quantification de biomolécules à l'aide de la spectrométrie de masse
Hofstadler et al. Analysis of nucleic acids by FTICR MS
US20020162622A1 (en) Mutation analysis using mass spectrometry
US20050042625A1 (en) Mass label linked hybridisation probes
EP2011884A1 (fr) Diagnostics ADN basés sur une spectrométrie de masse
US7056659B1 (en) Characterizing nucleic acids
JP2001516591A (ja) 質量分析法による核酸の分析方法
US6699668B1 (en) Mass label linked hybridisation probes
van den Boom et al. Analysis of nucleic acids by mass spectrometry
Fei Single nucleotide polymorphism analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050914

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080507

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20081014