JP2001507213A - 核酸の診断検出 - Google Patents
核酸の診断検出Info
- Publication number
- JP2001507213A JP2001507213A JP51690698A JP51690698A JP2001507213A JP 2001507213 A JP2001507213 A JP 2001507213A JP 51690698 A JP51690698 A JP 51690698A JP 51690698 A JP51690698 A JP 51690698A JP 2001507213 A JP2001507213 A JP 2001507213A
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- sequence
- target human
- human nucleic
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 生物サンプルにおける標的ヒト核酸の存在についてスクリーニングするた めの方法であって、 患者からの生物学的サンプルを用意し; 前記サンプルと、標的ヒト核酸配列に対して特異的にハイブリダイズする核酸 とを接触せしめ;そして 前記標的ヒト核酸配列の存在を検出する: ことを含んで成る方法。 2. 前記標的ヒト核酸がヒトゲノムにおける弱い部位(fragile site)からの 配列を含む請求の範囲第1項記載の方法。 3. 前記標的ヒト核酸が反復DNAに由来する配列を含む請求の範囲第1項記載 の方法。 4. 前記標的核酸が保管された(archived)核酸配列を含む請求の範囲第1項 記載の方法。 5. 前記反復DNAがAlu配列を含んで成る請求の範囲第3項記載の方法。 6. 前記標的ヒト核酸が制御配列を含む請求の範囲第1項記載の方法。 7. 前記標的ヒト核酸が少なくとも約100個の長さのヌクレオチドである請求 の範囲第1項記載の方法。 8. 前記標的ヒト核酸が約500〜約1500個の長さのヌクレオチドである請求の 範囲第7項記載の方法。 9. 前記標的ヒト核酸がRNAである請求の範囲第1項記載の方法。 10.前記標的ヒト核酸がDNAである請求の範囲第1項記載の方法。 11.前記生物学的サンプルが血漿である請求の範囲第1項記載の方法。 12.標的ヒト核酸の存在についてのスクリーニングが、疾病の処理をモニター するために使用される請求の範囲第1項記載の方法。 13.ヒト核酸の存在についてのスクリーニングが、疾病を診断するために使用 される請求の範囲第1項記載の方法。 14.前記疾病状態が慢性疾患である請求の範囲第13項記載の方法。 15.前記慢性疾患が癌である請求の範囲第14項記載の方法。 16.前記癌が多発性骨髄腫である請求の範囲第15項記載の方法。 17.前記慢性疾患が自己免疫疾患である請求の範囲第14項記載の方法。 18.前記慢性疾患が神経変性疾患である請求の範囲第14項記載の方法。 19.前記標的ヒト核酸が、配列番号1、配列番号2、又は配列番号3に示され るような配列を有するヒトゲノム配列に由来する請求の範囲第1項記載の方法。 20.前記接触段階が、標的ヒト核酸を増幅する段階を包含する請求の範囲第1 項記載の方法。 21.前記増幅段階が、ポリメラーゼ鎖反応(PCR)を用いて実施される請求の範 囲第20項記載の方法。 22.前記増幅段階が、配列番号1に示されるような配列を有するプライマーに 対して実質的に同一であるプライマーの使用を包含する請求の範囲第21項記載の 方法。 23.前記増幅段階が、配列番号2に示されるような配列を有するプライマーに 対して実質的に同一であるプライマーの使用を包含する請求の範囲第21項記載の 方法。 24.配列番号1、配列番号2又は配列番号3に示されるような配列を有する単 離された核酸分子。 25.異形成細胞を選択的に破壊することを含んで成る、慢性疾患を処理するた めの方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2676296P | 1996-10-04 | 1996-10-04 | |
US60/026,762 | 1996-10-04 | ||
PCT/US1997/017880 WO1998014617A1 (en) | 1996-10-04 | 1997-10-03 | Diagnostic detection of nucleic acids |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001507213A true JP2001507213A (ja) | 2001-06-05 |
JP2001507213A5 JP2001507213A5 (ja) | 2005-06-16 |
JP4044142B2 JP4044142B2 (ja) | 2008-02-06 |
Family
ID=21833653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51690698A Expired - Fee Related JP4044142B2 (ja) | 1996-10-04 | 1997-10-03 | 核酸の診断検出 |
Country Status (6)
Country | Link |
---|---|
US (2) | US6344317B2 (ja) |
EP (1) | EP0960210A4 (ja) |
JP (1) | JP4044142B2 (ja) |
AU (1) | AU4667297A (ja) |
CA (1) | CA2268069A1 (ja) |
WO (1) | WO1998014617A1 (ja) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8043835B1 (en) | 1996-03-26 | 2011-10-25 | Oncomedx, Inc. | Methods for detecting and monitoring cancer using extracellular RNA |
US6329179B1 (en) * | 1996-03-26 | 2001-12-11 | Oncomedx, Inc. | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer |
US7785842B2 (en) | 1996-03-26 | 2010-08-31 | Oncomedx, Inc. | Comparative analysis of extracellular RNA species |
US6759217B2 (en) * | 1996-03-26 | 2004-07-06 | Oncomedx, Inc. | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer |
US8440396B2 (en) | 1997-03-14 | 2013-05-14 | Oncomedx, Inc. | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer |
US20070009934A1 (en) * | 1997-03-14 | 2007-01-11 | Kopreski Michael S | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer |
US8163524B2 (en) * | 1998-09-22 | 2012-04-24 | Oncomedx, Inc. | Comparative analysis of extracellular RNA species |
US20060204989A1 (en) * | 1998-09-22 | 2006-09-14 | Kopreski Michael S | Comparative analysis of extracellular RNA species |
US20080261292A1 (en) * | 1998-09-22 | 2008-10-23 | Oncomedx, Inc. | Method Enabling the Use of Extracellular Ribonucleic Acid (RNA) Extracted from Plasma or Serum to Detect, Monitor or Evaluate Cancer or Premalignant Conditions |
CA2443170A1 (en) * | 2001-03-30 | 2002-10-10 | Chronix Biomedical, Inc. | Diagnostic detection of nucleic acids |
US9777312B2 (en) | 2001-06-30 | 2017-10-03 | Enzo Life Sciences, Inc. | Dual polarity analysis of nucleic acids |
US20040161741A1 (en) | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
DK1421215T3 (da) * | 2001-07-25 | 2011-06-27 | Oncomedx Inc | Fremgangsmåder til evaluering af patologiske tilstande under anvendelse af ekstracellulært RNA |
US20100159464A1 (en) * | 2001-11-05 | 2010-06-24 | Oncomedx, Inc. | Method for Detection of DNA Methyltransferase RNA in Plasma and Serum |
US20030104454A1 (en) * | 2001-11-05 | 2003-06-05 | Kopreski Michael S. | Method for detection of DNA methyltransferase RNA in plasma and serum |
US7767390B2 (en) | 2001-11-20 | 2010-08-03 | Oncomedx, Inc. | Methods for evaluating drug-resistance gene expression in the cancer patient |
US7022478B2 (en) | 2002-05-14 | 2006-04-04 | The Chinese University Of Hong Kong | Methods for evaluating stroke or cardiac ischemia by nucleic acid detection |
US20060099621A1 (en) * | 2004-10-07 | 2006-05-11 | Chronix Biomedical | Detection of nucleic acids to assess risk for Creutzfeldt-Jakob disease |
US7960357B2 (en) | 2005-10-07 | 2011-06-14 | California Institute Of Technology | PKR activation via hybridization chain reaction |
US7798645B2 (en) | 2006-05-16 | 2010-09-21 | Mark Costin Roser | Visual and memory stimulating retina self-monitoring system |
EP2155770B1 (en) | 2007-05-16 | 2013-10-16 | California Institute of Technology | A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
US20090136942A1 (en) * | 2007-09-18 | 2009-05-28 | Oncomedx, Inc. | Analysis of Extracellular RNA |
US9273100B2 (en) | 2007-11-09 | 2016-03-01 | Board Of Trustees Of Michigan State University | Use of Galerina marginata genes and proteins for peptide production |
US9518097B2 (en) * | 2007-11-09 | 2016-12-13 | Board Of Trustees Of Michigan State University | Identification and use of genes encoding amatoxin and phallotoxin |
US20110097704A1 (en) * | 2008-01-29 | 2011-04-28 | Ibis Biosciences, Inc. | Compositions for use in identification of picornaviruses |
US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
US9186128B2 (en) * | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
DE102009004269A1 (de) | 2009-01-07 | 2010-07-08 | Beiersdorf Ag | Diole als antitranspirantwirksames Mittel |
US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
US8962241B2 (en) * | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
WO2013174432A1 (en) | 2012-05-24 | 2013-11-28 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis |
ES2703764T3 (es) * | 2012-12-14 | 2019-03-12 | Chronix Biomedical | Biomarcadores personalizados para el cáncer |
US9856472B2 (en) | 2013-07-01 | 2018-01-02 | California Institute Of Technology | Small conditional RNAs |
US9984201B2 (en) | 2015-01-18 | 2018-05-29 | Youhealth Biotech, Limited | Method and system for determining cancer status |
WO2017210341A1 (en) | 2016-05-31 | 2017-12-07 | The Regents Of The University Of California | Methods for evaluating, monitoring, and modulating aging process |
DK3481843T3 (en) | 2016-07-05 | 2022-02-07 | California Inst Of Techn | Fractional initiator hybridization chain reaction |
US10093986B2 (en) | 2016-07-06 | 2018-10-09 | Youhealth Biotech, Limited | Leukemia methylation markers and uses thereof |
EP3481941A4 (en) | 2016-07-06 | 2020-04-15 | Youhealth Biotech, Limited | BREAST AND OVARY CANCER METHYLATION MARKERS AND USES THEREOF |
EP3481403B1 (en) | 2016-07-06 | 2022-02-09 | Youhealth Biotech, Limited | Solid tumor methylation markers and uses thereof |
US10815519B2 (en) | 2016-08-30 | 2020-10-27 | California Institute Of Technology | Immunohistochemistry via hybridization chain reaction |
EP3589371A4 (en) | 2017-03-02 | 2020-11-25 | Youhealth Oncotech, Limited | METHYLATION MARKERS FOR THE DIAGNOSIS OF HEPER CELL CARCINOMA AND LUNG CANCER |
EP3609586B1 (en) | 2017-04-10 | 2023-12-06 | Ank Partners Inc. | Golf system |
US11873485B2 (en) | 2021-01-26 | 2024-01-16 | California Institute Of Technology | Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4965189A (en) | 1986-07-01 | 1990-10-23 | University Of Massachusetts Medical School | Probes for the determination of the proclivity for development of autoimmune diseases |
WO1993022456A1 (en) * | 1992-04-27 | 1993-11-11 | Trustees Of Dartmouth College | Detection of gene sequences in biological fluids |
US5242657A (en) * | 1992-07-02 | 1993-09-07 | Waukesha Foundry, Inc. | Lead-free corrosion resistant copper-nickel alloy |
CA2092455A1 (en) * | 1993-03-25 | 1994-09-26 | Johanna M. Rommens | Process for isolating genes and the gene causative of huntington disease |
US5352407A (en) * | 1993-04-29 | 1994-10-04 | Seelig Karl F | Lead-free bismuth free tin alloy solder composition |
US5405577A (en) * | 1993-04-29 | 1995-04-11 | Seelig; Karl F. | Lead-free and bismuth-free tin alloy solder composition |
US5455044A (en) * | 1993-05-14 | 1995-10-03 | Depotech Corporation | Method for treating neurological disorders |
US5411703A (en) * | 1993-06-16 | 1995-05-02 | International Business Machines Corporation | Lead-free, tin, antimony, bismtuh, copper solder alloy |
US5393489A (en) * | 1993-06-16 | 1995-02-28 | International Business Machines Corporation | High temperature, lead-free, tin based solder composition |
US5410184A (en) * | 1993-10-04 | 1995-04-25 | Motorola | Microelectronic package comprising tin-copper solder bump interconnections, and method for forming same |
US5435968A (en) * | 1994-01-21 | 1995-07-25 | Touchstone, Inc. | A lead-free solder composition |
US5639600A (en) * | 1994-08-05 | 1997-06-17 | The Regents Of The University Of California | Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement |
JP2805595B2 (ja) * | 1994-11-02 | 1998-09-30 | 三井金属鉱業株式会社 | 鉛無含有半田合金 |
FR2737500B1 (fr) * | 1995-08-03 | 1997-08-29 | Bio Merieux | Materiel viral et fragments nucleotidiques associes a la sclerose en plaques, a des fins de diagnostic, prophylactiques et therapeutiques |
GB9518154D0 (en) * | 1995-09-06 | 1995-11-08 | Lynxvale Ltd | Oligonucleotides and their use |
JPH09155587A (ja) * | 1995-11-30 | 1997-06-17 | Mitsui Mining & Smelting Co Ltd | 錫−亜鉛系無鉛半田合金 |
US6329179B1 (en) * | 1996-03-26 | 2001-12-11 | Oncomedx, Inc. | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer |
US5837191A (en) * | 1996-10-22 | 1998-11-17 | Johnson Manufacturing Company | Lead-free solder |
US5863493A (en) * | 1996-12-16 | 1999-01-26 | Ford Motor Company | Lead-free solder compositions |
-
1997
- 1997-10-03 WO PCT/US1997/017880 patent/WO1998014617A1/en active Application Filing
- 1997-10-03 CA CA002268069A patent/CA2268069A1/en not_active Abandoned
- 1997-10-03 JP JP51690698A patent/JP4044142B2/ja not_active Expired - Fee Related
- 1997-10-03 AU AU46672/97A patent/AU4667297A/en not_active Abandoned
- 1997-10-03 US US08/943,607 patent/US6344317B2/en not_active Expired - Lifetime
- 1997-10-03 EP EP97945474A patent/EP0960210A4/en not_active Withdrawn
-
2001
- 2001-09-19 US US09/957,215 patent/US20030077588A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0960210A4 (en) | 2004-06-09 |
US20010014445A1 (en) | 2001-08-16 |
AU4667297A (en) | 1998-04-24 |
US20030077588A1 (en) | 2003-04-24 |
JP4044142B2 (ja) | 2008-02-06 |
CA2268069A1 (en) | 1998-04-09 |
EP0960210A1 (en) | 1999-12-01 |
US6344317B2 (en) | 2002-02-05 |
WO1998014617A1 (en) | 1998-04-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4044142B2 (ja) | 核酸の診断検出 | |
Muir et al. | Rapid diagnosis of enterovirus infection by magnetic bead extraction and polymerase chain reaction detection of enterovirus RNA in clinical specimens | |
US8574844B2 (en) | Quantitative real-time assay for Noroviruses and Enteroviruses with built in quality control standard | |
JP2014507950A (ja) | 混合個体群における標的dnaを配列決定するためのキットおよび方法 | |
AU2015358251A1 (en) | Methods and reagents for detecting neisseria gonorrhoeae and its antimicrobial resistance determinants | |
EP0932702B1 (en) | Detection and identification of non-polio enteroviruses | |
CN112824535A (zh) | 基因突变多重检测用引物组合物及其试剂盒 | |
WO2010123058A1 (ja) | 塩基変異判別用プローブセットおよび塩基変異の判別方法 | |
WO2023279042A2 (en) | Compositions and methods for detection of severe acute respiratory syndrome coronavirus 2 variants | |
EP4022086A1 (en) | Compositions and methods for amplification and detection of hepatitis b virus rna, including hbv rna transcribed from cccdna | |
CN106148497A (zh) | Braf基因突变检测试剂盒及其应用 | |
Chhabra et al. | Molecular detection methods of foodborne viruses | |
US20020102548A1 (en) | Methods for the preparation and use of internal standards for nucleic acid amplification assays | |
JP5315519B2 (ja) | コイヘルペスウイルス(khv)の検出方法 | |
US9631243B2 (en) | Methods and compositions for identifying JC virus | |
Waku-Kouomou et al. | Genotyping measles virus by real-time amplification refractory mutation system PCR represents a rapid approach for measles outbreak investigations | |
US20030219772A1 (en) | Means and methods for treatment evaluation | |
WO2000058477A1 (fr) | Procede de detection d'une mutation dans le virus de l'hepatite b et kit de detection | |
ŽUsinaite et al. | Hepatitis C virus genotypes in Estonia | |
US20030082644A1 (en) | Diagnostic detection of nucleic acids | |
WO2022258056A1 (en) | Methods and compositions for identifying viral sequences | |
Bishop et al. | The presence and expression of RNA tumor virus genes in normal and infected cells: Detection by molecular hybridization | |
Lute et al. | Multiplex RT Q-PCR assay for simultaneous quantification of three viruses used for validation of virus clearance by biopharmaceutical production | |
Nigatie | Detection of Plasmodium falciparum and P. vivax Mixed Infection Level and Identification of Pfcrt and Pfmdr1 Resistance Mutations in North-West Ethiopia | |
JP6483336B2 (ja) | Hav検出 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041001 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041013 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070529 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070828 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20071016 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20071115 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101122 Year of fee payment: 3 |
|
LAPS | Cancellation because of no payment of annual fees |