JP2001503784A - グリコペプチド抗生物質の還元的アルキル化のための還元剤 - Google Patents
グリコペプチド抗生物質の還元的アルキル化のための還元剤Info
- Publication number
- JP2001503784A JP2001503784A JP52383898A JP52383898A JP2001503784A JP 2001503784 A JP2001503784 A JP 2001503784A JP 52383898 A JP52383898 A JP 52383898A JP 52383898 A JP52383898 A JP 52383898A JP 2001503784 A JP2001503784 A JP 2001503784A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- glycopeptide
- alkoxy
- copper
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.アミンを含むグリコペプチド抗生物質を還元的にアルキル化する方法におい て、そのグリコペプチド抗生物質を還元剤の存在下にアルデヒドまたはケトンと 反応させることを含んでなる方法であって、その改良点がピリジン・ボランを還 元剤として使用することを含んでなる方法。 2.メタノール中、58−63℃の温度で行う、請求項1に記載の方法。 3.グリコペプチド抗生物質、アルデヒドまたはケトン、および還元剤の一部を 同時一緒に混合して、その後、還元剤の1以上の追加部分を加える、請求項1ま たは2に記載の方法。 4.可溶性銅をさらに加える、請求項1−3のいずれかに記載の方法。 5.グリコペプチド抗生物質がバンコマイシン、A82846A、A82846 B、A82846C、またはオリエンティシンAである、請求項1−4のいずれ かに記載の方法。 6.グリコペプチド抗生物質がA82846Bである、請求項1−5のいずれか に記載の方法。 7.ケトンまたはアルデヒドが4'−クロロ−4−ビフェニルカルボギシアルデ ヒドである、請求項1−6のいずれかに記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3159596P | 1996-11-21 | 1996-11-21 | |
US60/031,595 | 1996-11-21 | ||
PCT/US1997/021126 WO1998021952A1 (en) | 1996-11-21 | 1997-11-20 | Reducing agent for reductive alkylation of glycopeptide antibiotics |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001503784A true JP2001503784A (ja) | 2001-03-21 |
Family
ID=21860365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52383898A Ceased JP2001503784A (ja) | 1996-11-21 | 1997-11-20 | グリコペプチド抗生物質の還元的アルキル化のための還元剤 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5939382A (ja) |
EP (1) | EP0845477B1 (ja) |
JP (1) | JP2001503784A (ja) |
AR (1) | AR010622A1 (ja) |
AT (1) | ATE296834T1 (ja) |
AU (1) | AU5358598A (ja) |
CA (1) | CA2272261C (ja) |
CO (1) | CO4930279A1 (ja) |
DE (1) | DE69733401T2 (ja) |
HK (1) | HK1011543A1 (ja) |
ID (1) | ID19281A (ja) |
MY (1) | MY122001A (ja) |
PE (1) | PE37199A1 (ja) |
WO (1) | WO1998021952A1 (ja) |
ZA (1) | ZA9710427B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017521443A (ja) * | 2014-07-17 | 2017-08-03 | ザ メディシンズ カンパニー | 高純度のオリタバンシン及びその製造方法 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6518242B1 (en) | 1998-02-20 | 2003-02-11 | Theravance, Inc. | Derivatives of glycopeptide antibacterial agents |
SI1140993T1 (en) | 1998-12-23 | 2003-12-31 | Theravance, Inc. | Glycopeptide derivatives and pharmaceutical compositions containing the same |
US6831150B2 (en) | 2000-05-02 | 2004-12-14 | Theravance, Inc. | Reductive alkylation process |
TWI312785B (en) | 2001-08-24 | 2009-08-01 | Theravance Inc | Process for preparing vancomycin derivatives |
TWI275594B (en) | 2001-08-24 | 2007-03-11 | Theravance Inc | Process for preparing vancomycin phosphonate derivatives |
CA2904387C (en) | 2013-03-15 | 2021-12-07 | Melinta Therapeutics, Inc. | Methods of treating infections in overweight and obese patients using antibiotics |
CN106188243B (zh) * | 2015-05-05 | 2020-06-26 | 博瑞生物医药(苏州)股份有限公司 | 一种奥利万星的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4698327A (en) * | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
US4877450A (en) * | 1989-02-23 | 1989-10-31 | Learonal, Inc. | Formaldehyde-free electroless copper plating solutions |
CA2031803C (en) * | 1989-12-13 | 2001-05-29 | Ramakrishnan Nagarajan | Improvements in or relating to glycopeptide deriveratives |
JPH05310772A (ja) * | 1992-05-07 | 1993-11-22 | Microbial Chem Res Found | アントラサイクリン抗生物質の製造方法 |
TW457248B (en) * | 1994-01-28 | 2001-10-01 | Lilly Co Eli | Glycopeptide antibiotic derivatives |
-
1997
- 1997-11-12 US US08/968,320 patent/US5939382A/en not_active Expired - Fee Related
- 1997-11-19 AR ARP970105412A patent/AR010622A1/es active IP Right Grant
- 1997-11-19 DE DE69733401T patent/DE69733401T2/de not_active Expired - Fee Related
- 1997-11-19 PE PE1997001053A patent/PE37199A1/es not_active Application Discontinuation
- 1997-11-19 MY MYPI97005547A patent/MY122001A/en unknown
- 1997-11-19 AT AT97309297T patent/ATE296834T1/de not_active IP Right Cessation
- 1997-11-19 EP EP97309297A patent/EP0845477B1/en not_active Expired - Lifetime
- 1997-11-19 ZA ZA9710427A patent/ZA9710427B/xx unknown
- 1997-11-19 CO CO97067570A patent/CO4930279A1/es unknown
- 1997-11-20 JP JP52383898A patent/JP2001503784A/ja not_active Ceased
- 1997-11-20 ID IDP973720A patent/ID19281A/id unknown
- 1997-11-20 CA CA002272261A patent/CA2272261C/en not_active Expired - Fee Related
- 1997-11-20 WO PCT/US1997/021126 patent/WO1998021952A1/en active Search and Examination
- 1997-11-20 AU AU53585/98A patent/AU5358598A/en not_active Abandoned
-
1998
- 1998-12-03 HK HK98112781A patent/HK1011543A1/xx not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017521443A (ja) * | 2014-07-17 | 2017-08-03 | ザ メディシンズ カンパニー | 高純度のオリタバンシン及びその製造方法 |
US10328118B2 (en) | 2014-07-17 | 2019-06-25 | Melinta Therapeutics, Inc. | High purity oritavancin and method of producing same |
US10864249B2 (en) | 2014-07-17 | 2020-12-15 | Melinta Therapeutics, Inc. | High purity oritavancin and method of producing same |
Also Published As
Publication number | Publication date |
---|---|
ATE296834T1 (de) | 2005-06-15 |
DE69733401T2 (de) | 2006-04-27 |
WO1998021952A1 (en) | 1998-05-28 |
AR010622A1 (es) | 2000-06-28 |
DE69733401D1 (de) | 2005-07-07 |
CA2272261C (en) | 2008-01-08 |
HK1011543A1 (en) | 1999-07-16 |
ZA9710427B (en) | 1999-05-19 |
AU5358598A (en) | 1998-06-10 |
ID19281A (id) | 1998-06-28 |
CO4930279A1 (es) | 2000-06-27 |
PE37199A1 (es) | 1999-04-14 |
CA2272261A1 (en) | 1998-05-28 |
MY122001A (en) | 2006-03-31 |
US5939382A (en) | 1999-08-17 |
EP0845477B1 (en) | 2005-06-01 |
EP0845477A1 (en) | 1998-06-03 |
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Legal Events
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