JP2001500126A - アルキル化ラパマイシン誘導体 - Google Patents
アルキル化ラパマイシン誘導体Info
- Publication number
- JP2001500126A JP2001500126A JP10512815A JP51281598A JP2001500126A JP 2001500126 A JP2001500126 A JP 2001500126A JP 10512815 A JP10512815 A JP 10512815A JP 51281598 A JP51281598 A JP 51281598A JP 2001500126 A JP2001500126 A JP 2001500126A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- alkenyl
- phenyl
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70959196A | 1996-09-09 | 1996-09-09 | |
| US08/709,591 | 1996-09-09 | ||
| PCT/US1997/015439 WO1998009970A2 (en) | 1996-09-09 | 1997-09-03 | Alkylated rapamycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001500126A true JP2001500126A (ja) | 2001-01-09 |
Family
ID=24850507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10512815A Pending JP2001500126A (ja) | 1996-09-09 | 1997-09-03 | アルキル化ラパマイシン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0927182A2 (de) |
| JP (1) | JP2001500126A (de) |
| CN (1) | CN1235608A (de) |
| AU (1) | AU4176897A (de) |
| CA (1) | CA2266039A1 (de) |
| WO (1) | WO1998009970A2 (de) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005281296A (ja) * | 2004-03-01 | 2005-10-13 | Terumo Corp | Ｏ−アルキル化ラパマイシン誘導体の製造法 |
| JP2016523246A (ja) * | 2013-06-20 | 2016-08-08 | ノバルティス アーゲー | アルキルフルオロアルキルスルホネートによるアルキル化 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| US6890546B2 (en) | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
| TW557297B (en) * | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
| US7455853B2 (en) | 1998-09-24 | 2008-11-25 | Abbott Cardiovascular Systems Inc. | Medical devices containing rapamycin analogs |
| LT3351246T (lt) | 2001-02-19 | 2019-07-10 | Novartis Pharma Ag | Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui |
| EP1419153A1 (de) * | 2001-08-22 | 2004-05-19 | Wyeth | Rapamycindialdehyde |
| EP1419154B1 (de) * | 2001-08-22 | 2005-10-05 | Wyeth | Rapanycin29-enole |
| KR100956195B1 (ko) | 2002-02-01 | 2010-05-06 | 어리어드 파마슈티칼스, 인코포레이티드 | 인 함유 화합물 및 이의 용도 |
| WO2004060283A2 (en) | 2002-12-16 | 2004-07-22 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| WO2014082286A1 (en) * | 2012-11-30 | 2014-06-05 | Hangzhou Zylox Pharma Co., Ltd. | Rafamycin analogs and methods for making same |
| DK3813946T3 (da) | 2018-06-15 | 2024-08-19 | Janssen Pharmaceutica Nv | Rapamycin-analoger og anvendelser deraf |
| JP2023506410A (ja) | 2019-12-05 | 2023-02-16 | アナクリア セラピューティクス， インコーポレイテッド | ラパマイシン類似体及びその使用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5151413A (en) * | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| ZA935111B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
| ZA935112B (en) * | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5258389A (en) * | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| GB9307491D0 (en) * | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
-
1997
- 1997-09-03 CN CN97199423A patent/CN1235608A/zh active Pending
- 1997-09-03 EP EP97939749A patent/EP0927182A2/de not_active Withdrawn
- 1997-09-03 JP JP10512815A patent/JP2001500126A/ja active Pending
- 1997-09-03 AU AU41768/97A patent/AU4176897A/en not_active Abandoned
- 1997-09-03 WO PCT/US1997/015439 patent/WO1998009970A2/en not_active Application Discontinuation
- 1997-09-03 CA CA002266039A patent/CA2266039A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005281296A (ja) * | 2004-03-01 | 2005-10-13 | Terumo Corp | Ｏ−アルキル化ラパマイシン誘導体の製造法 |
| JP4716280B2 (ja) * | 2004-03-01 | 2011-07-06 | テルモ株式会社 | Ｏ−アルキル化ラパマイシン誘導体の製造法 |
| JP2016523246A (ja) * | 2013-06-20 | 2016-08-08 | ノバルティス アーゲー | アルキルフルオロアルキルスルホネートによるアルキル化 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998009970A2 (en) | 1998-03-12 |
| WO1998009970A3 (en) | 1998-04-16 |
| CN1235608A (zh) | 1999-11-17 |
| AU4176897A (en) | 1998-03-26 |
| EP0927182A2 (de) | 1999-07-07 |
| CA2266039A1 (en) | 1998-03-12 |
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