JP2001352938A - Health food - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a health food capable of ameliorating a symptom such as a chapped skin, shrink of the skin, etc., by the intake of the health food and alleviating a symptom of general malaise such as a daily irritating feeling, etc. SOLUTION: This health food is characterized by comprising Oenanthe javanica and/or its extract.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to health foods, and more particularly to health foods containing seri (Oenanthe javanica (Bl.) DC.). The purpose of the present invention is to provide symptoms such as rough and dull skin due to ingestion. It is an object of the present invention to provide a health food that can improve symptoms and alleviate symptoms of indefinite complaints such as daily frustration.

[0002]

[Prior Art] Seri (Oena) is one of the seven spring herbs
nthe javanica (Bl.) DC.) is one of the plants that has been used and eaten since ancient times, as its name appears in Kojiki and Manyoshu. Seri is used as an ingredient for spices and the like because of its aroma, and is also used as a crude drug. Seri's crude drug name is "Suikin",
It is known to have effects such as appetite enhancement, fever relief, diuresis, and laxity.

[0003] Another function of the auction is disclosed in
As disclosed in JP-A-13726, it is known to have a skin-beautifying effect for preventing roughening and dullness of the skin or alleviating symptoms. Also, Japanese Unexamined Patent Publication No.
As disclosed in Japanese Patent Publication No. 06277, a water or alcohol extract of a plant containing serica has a skin activating action that increases the luster of the skin, reduces the sagging and the soaking of the skin, and improves the cosmetic paste. It is known.

[0004]

DISCLOSURE OF THE INVENTION The inventors of the present invention have conducted intensive studies focusing on the excellent action of auction, and found that in addition to the action of stimulating the skin and the skin, in addition to the symptoms of indeterminate complaints such as daily irritation. It has been found that the active ingredient is a saikosaponin, a kind of saponins, and the present invention has been completed.

[0005]

Means for Solving the Problems The invention according to claim 1 relates to a health food characterized by containing saliva (Oenanthe javanica (Bl.) DC.) And / or an extract thereof. The invention according to claim 2 relates to a health food characterized by containing a saikosaponin. The invention according to claim 3 is characterized in that the saikosaponins are: saikosaponin a, saikosaponin b1, saikosaponin b2,
The health food according to claim 2, comprising at least one selected from saikosaponin c, saikosaponin d, and saikosaponin h.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The health food according to the present invention is characterized in that it contains seri (Oenanthe javanica (Bl.) DC.) Or an extract thereof. The reason for this is that the seri or its extract is effective in activating beautiful skin and skin, and can alleviate the symptoms of indefinite complaints such as daily frustration.

Seri (Oenanthe javanica (Bl.) DC.)
Is a dicotyledonous plant belonging to the Umbelliferae family, and is one of the special plants of Japan growing in swamps. In the present invention, all parts of the above-ground part and the underground part of the seri (Oenanthe javanica (Bl.) DC.) Can be used, and the whole plant can be used or its seeds, fruits, flowers, leaves, Each part, such as a root part and a stem part, may be used alone or in combination as appropriate. In the present invention, it is preferable to use leaves or roots.

[0008] The form of use of seri (Oenanthe javanica (Bl.) DC.) Is not particularly limited, and it may be used as it is as a powder or as an extract. The extraction solvent used when obtaining the extract is not particularly limited, and a hydrophilic organic solvent such as water or alcohol, or a mixture thereof can be suitably used. In addition, as a hydrophilic organic solvent, monohydric alcohols, such as methanol and ethanol, polyhydric alcohols, acetone, etc. can be illustrated. Examples of the extraction method include a cold immersion method and a hot immersion method, and furthermore, a purification treatment can be performed, but there is no particular limitation. Among the extracts obtained by the method,
When using an extraction solvent that is highly safe for the human body such as water or ethanol, it can be used as it is, or it can be concentrated and used as a soft extract, or it can be dried by freeze drying or spray drying and used as a dry extract It does not matter. When extraction is performed using another extraction solvent, it is preferable that the extract be dried by freeze drying or spray drying and used as a dry extract.

[0009] The above-mentioned seri (Oenanthe javanica (Bl.)
DC.), Especially in its leaves and roots, including essential oil components,
It contains vitamins such as vitamin A and vitamin C, minerals such as iron and calcium, and saikosaponins. Of these, psychosaponins are one of the main active ingredients that relieve symptoms such as rough and dull skin.
It is also one of the main active ingredients that alleviate the symptoms of indefinite complaints such as daily irritation.

[0010] Psychosaponins are a kind of saponins contained in a perennial plant of the Umbelliferae family, Bupleurum falcatum L., and have a serum cholesterol level reduction, anti-inflammatory and anti-allergic effects. It has been known. Specifically, as the saikosaponins, a saikosaponin a represented by the following formula 1 (formula 1), a saikosaponin b1 represented by the following formula 2 (formula 2), and a saikosaponin represented by the following formula 3 (formula 3) b2, saikosaponin c represented by the following formula 4 (formula 4), saikosaponin d represented by the following formula 5 (formula 5), and saikosaponin h represented by the following formula 6 (formula 6).

[0011]

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[0012]

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[0013]

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[0014]

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[0015]

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[0016]

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In the case of using an extract of seri, when used as a mixture without purification treatment, it contains various components as described above in addition to the saikosaponins which are the main active ingredients. The synergistic effect of each component is exhibited. In addition, when subjected to a purification treatment and used as an extract containing a large amount of saikosaponins or an extract containing substantially only saikosaponins, the effect of saikosaponins alone, which is a main active ingredient, is exhibited. Is done.

The following is an example of a purification method using an extract containing a large amount of saikosaponins or an extract consisting essentially of saikosaponins. As a first method for obtaining an extract containing substantially only saikosaponins, first, the plant is heated to reflux with about 2 to 5 times by weight of water or a lower alcohol such as methanol or ethanol, and then filtered. To obtain an extract. Note that this extraction operation may be repeated as needed. next,
The solvent of the extract is distilled off under reduced pressure to obtain an extract. After the extracted extract is partitioned between n-butanol and water by a usual method, the solvent is distilled off from the n-butanol layer under reduced pressure, whereby an extract consisting essentially of saikosaponins can be obtained.

As a second method, first, the above-mentioned plant is
The mixture is heated to reflux with a water or a lower alcohol such as methanol or ethanol in an amount of about 5 times by weight, and then filtered to obtain an extract. Note that this extraction operation may be repeated as needed. Next, the solvent of the extract was distilled off under reduced pressure and concentrated.
The concentrate is dissolved in water or water containing less than about 30% lower alcohol. The obtained solution is adsorbed on a polystyrene resin adsorbent (for example, Amberlite XAD-1 or Amberlite XAD-2). In addition, these adsorbents are used 20 to 300 times by weight, preferably 40 to 150 times by weight of the contained saikosaponins. Finally, after washing the adsorbent with water or water containing about 30% or less of lower alcohol, eluting with water containing about 30% or more of lower alcohol, and then distilling off the solvent under reduced pressure to substantially remove saikosaponins. It is possible to obtain an extract containing only the above.

As a third method, first, the above-mentioned plant is
The mixture is heated to reflux with a water or a lower alcohol such as methanol or ethanol in an amount of about 5 times by weight, and then filtered to obtain an extract. Note that this extraction operation may be repeated as needed. Next, the solvent of the extract was distilled off under reduced pressure and concentrated.
Dissolve the concentrate in n-butanol, then add water and shake to stand. The extract containing substantially only saikosaponins can be obtained by concentrating the obtained n-butanol layer.

Each of the saikosaponins can be isolated by purifying the extract obtained by the above-described first to third methods by silica gel column chromatography or high performance liquid chromatography.

In the health food according to the present invention,
The amount of nanthe javanica (Bl.) DC.) is not particularly limited, but is 0.005% by weight or more, preferably 0.005% to 20% by weight, more preferably 0.01% to It may be adjusted to be 10% by weight. This is because if the amount is less than 0.005% by weight, the effect of the compounding cannot be sufficiently exhibited.

The daily intake of the health food according to the present invention is not particularly limited, but the intake of the active ingredient is 20 to 3000.
It is advisable to take 2 or 3 times a day so as to obtain mg. This means that if your daily intake is less than 20 mg,
This is because a sufficient effect cannot be obtained, and even if the dose exceeds 3000 mg, no further effect can be expected, and any case is not preferable.

Further, in the health food according to the present invention, preservatives, coloring agents, sweeteners, antioxidants, thickening stabilizers, gum bases, bittering agents, enzymes, and gloss, which are components usually added to foods, are included. Food additives such as agents, acidulants, seasonings, emulsifiers, enhancers, manufacturing agents, preservatives, excipients, and surfactants can be appropriately added as appropriate. Further, both synthetic additives and natural additives can be suitably used.

The form of the health food according to the present invention is not particularly limited, and may be a drink, a tablet, a powder, a granule or the like, or may be a jam, a candy, a jelly, a soft drink or the like.

[0026]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail based on embodiments. However, the present invention is not limited at all by the following examples. (Example 1) A dried pulverized leaf of a leaf of Oenanthe javanica (Bl.) DC. Was used as a sample of Example 1.

(Example 2) Seri (Oenanthe javanica (B
l.) The dried and ground whole plant of DC.) was used as a sample of Example 2.

Example 3 Oenanthe javanica (B
l.) To 2.5 kg of the dried and ground whole plant of DC.), 10 L of methanol was added, and the mixture was heated under reflux for 5 hours. The methanol was distilled off under reduced pressure to obtain 0.4 kg of a cell extract. next,
0.4 kg of the seri extract was mixed with n-butanol and water (1: 1,
(4 liters), the n-butanol layer was distilled off under reduced pressure, and 14 g of saikosaponins obtained as a sample of Example 3.

(Test Example 1) Three kinds of powders were prepared from the samples of Examples 1 to 3 according to the compositions shown in Table 1.

[Table 1]

[0030] Thirty women, usually suffering from irritation, were divided into three groups of ten. Each of the three groups was divided into the three powders prepared above (1 packet 2.1).
g) was taken as a group to take one pack per morning and evening. Interviews were conducted every two weeks to determine the degree of irritation. The degree of decrease in irritability after 10 weeks was scored in four stages shown in Table 2. At the same time, a questionnaire was given at the same time regarding the presence or absence of symptoms that could be considered as side effects such as drowsiness and drowsiness during the administration period.

[Table 2]

Table 3 shows the result of calculating the average value of the points of 10 persons.
Shown in

[Table 3]

As can be seen from the results shown in Table 3, the health food according to the present invention can improve daily irritability by ingestion. In addition, none of the subjects confirmed any symptoms that could be a side effect of taking the drug.

(Test Example 2) Twenty women aged 24 to 53 years were divided into two groups of 10 women. One of the two groups is a group for observing the degree of improvement of dullness of the skin, and the other is a group for observing the degree of improvement of dullness of the skin. I let it.
The degree of skin roughness and dullness of the skin before taking it and the degree of dullness and dullness of the skin four weeks after taking it were rated on a five-point scale shown in Table 4.

[Table 4]

Table 5 shows the results. In the table, “Excellent effect” means that the evaluation increased by three or more levels, and
The effect was graded up, the effect was slightly increased when the evaluation increased by one stage, the ineffective was an evaluation that did not increase at all, and the improvement rate was the sum of the significant effect and the effective (effective group). This is the percentage of the total.

[Table 5]

As can be seen from the results shown in Table 5, the health food according to the present invention can improve rough and dull skin by ingestion.

Hereinafter, examples of the composition of the health food according to the present invention will be described. (Formulation Example 1)

[Table 6]

(Formulation Example 2)

[Table 7]

[0038]

As described above, the health food according to the present invention is
he javanica (Bl.) DC.) or an extract thereof, so that ingestion can alleviate skin troubles such as rough and dull skin, as well as alleviate the symptoms of indefinite complaints such as frustration. Seri, which is an active ingredient, has been conventionally used for food and is therefore a health food highly safe for the human body.

Claims (3)

[Claims] 1. Seri (Oenanthe javanica (Bl.) DC.)
And / or an extract thereof. 2. A health food comprising a saikosaponin. 3. The saikosaponins comprising at least one selected from saikosaponin a, saikosaponin b1, saikosaponin b2, saikosaponin c, saikosaponin d, and saikosaponin h. 3. The health food according to 2.