JP2001340378A - Medical or sanitary article - Google Patents
Medical or sanitary articleInfo
- Publication number
- JP2001340378A JP2001340378A JP2000159774A JP2000159774A JP2001340378A JP 2001340378 A JP2001340378 A JP 2001340378A JP 2000159774 A JP2000159774 A JP 2000159774A JP 2000159774 A JP2000159774 A JP 2000159774A JP 2001340378 A JP2001340378 A JP 2001340378A
- Authority
- JP
- Japan
- Prior art keywords
- medical
- amino acid
- basic amino
- partial ester
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920002678 cellulose Polymers 0.000 claims abstract description 36
- 239000001913 cellulose Substances 0.000 claims abstract description 35
- 150000001413 amino acids Chemical class 0.000 claims abstract description 25
- 150000002148 esters Chemical class 0.000 claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 239000000470 constituent Substances 0.000 claims abstract description 6
- 239000004745 nonwoven fabric Substances 0.000 claims description 11
- 229920000742 Cotton Polymers 0.000 claims description 5
- 206010021639 Incontinence Diseases 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 210000000481 breast Anatomy 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 14
- 235000001014 amino acid Nutrition 0.000 description 26
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 21
- -1 Organic acid salts Chemical class 0.000 description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
- 239000004472 Lysine Substances 0.000 description 12
- 235000019766 L-Lysine Nutrition 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- XQYZOBNLCUAXLF-XRIGFGBMSA-N [(2s)-5-[[amino(azaniumyl)methylidene]amino]-1-methoxy-1-oxopentan-2-yl]azanium;dichloride Chemical compound Cl.Cl.COC(=O)[C@@H](N)CCCN=C(N)N XQYZOBNLCUAXLF-XRIGFGBMSA-N 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 4
- 229930064664 L-arginine Natural products 0.000 description 4
- 235000014852 L-arginine Nutrition 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 235000009697 arginine Nutrition 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- 230000032050 esterification Effects 0.000 description 3
- 238000005886 esterification reaction Methods 0.000 description 3
- 235000018977 lysine Nutrition 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- SXZCBVCQHOJXDR-ILKKLZGPSA-N hydron;methyl (2s)-2,6-diaminohexanoate;dichloride Chemical compound Cl.Cl.COC(=O)[C@@H](N)CCCCN SXZCBVCQHOJXDR-ILKKLZGPSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229960003104 ornithine Drugs 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- ODHCTXKNWHHXJC-VKHMYHEASA-M 5-oxo-L-prolinate Chemical compound [O-]C(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-M 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 101100441312 Arabidopsis thaliana CST gene Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 101000795655 Canis lupus familiaris Thymic stromal cotransporter homolog Proteins 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241001333951 Escherichia coli O157 Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102100037260 Gap junction beta-1 protein Human genes 0.000 description 1
- 101100276172 Homo sapiens GJB1 gene Proteins 0.000 description 1
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 description 1
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 239000002841 Lewis acid Substances 0.000 description 1
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 229960001859 domiphen bromide Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940096118 ella Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- BHQQXAOBIZQEGI-UHFFFAOYSA-N methyl 2-chlorobutanoate Chemical compound CCC(Cl)C(=O)OC BHQQXAOBIZQEGI-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229940071139 pyrrolidone carboxylate Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000012607 strong cation exchange resin Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Classifications
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/224—Esters of carboxylic acids; Esters of carbonic acid
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
- D06M13/325—Amines
- D06M13/342—Amino-carboxylic acids; Betaines; Aminosulfonic acids; Sulfo-betaines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/02—Natural fibres, other than mineral fibres
- D06M2101/04—Vegetal fibres
- D06M2101/06—Vegetal fibres cellulosic
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Textile Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Nonwoven Fabrics (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、抗菌性、安全性に
優れた医療または衛生用品に関する。より詳細には、本
発明は塩基性アミノ酸セルロース部分エステル及び/ま
たはその塩を構成成分とする医療または衛生用品に関す
る。[0001] The present invention relates to medical or hygiene articles excellent in antibacterial properties and safety. More particularly, the present invention relates to medical or hygiene products comprising a basic amino acid cellulose partial ester and / or a salt thereof.
【0002】[0002]
【従来の技術】近年、メチシリン耐性黄色ブドウ球菌
(MRSA)や病原性大腸菌O−157による感染の社
会問題化を背景に様々な分野で新規な抗菌製品が数多く
市場に出されてきた。紙おむつ、失禁パッド、生理用ナ
プキン、生理用タンポン、パンティシート、汗取りパッ
ド、母乳パッド、医療用タンポン、綿棒、救急絆創膏、
ウエットティッシュー、サージカルドレッシング、医療
用マスク、ガーゼ、包帯、医療用シーツ、医療用タオ
ル、医療用ドレープ、術者用ガウン、患者衣、医療用キ
ャップ、医療用エプロン、医療用カバーといった医療ま
たは衛生用品に於いても、これらの製品が直接皮膚、粘
膜または傷口に接触し、使用時には生体から分泌、滲出
あるいは排出された液体を吸収することで微生物の繁殖
し易い環境となるものであったり、また、手術等の細菌
汚染を極度に嫌う医療現場で使用されるものであること
を考えると、感染症予防の観点から抗菌性は重要な機能
の一つと考えられる。2. Description of the Related Art In recent years, a number of new antibacterial products have been put on the market in various fields against the background of the social problem of infection by methicillin-resistant Staphylococcus aureus (MRSA) and pathogenic Escherichia coli O-157. Disposable diapers, incontinence pads, sanitary napkins, sanitary tampons, panty sheets, sweat-absorbing pads, breastfeeding pads, medical tampons, cotton swabs, first aid plasters,
Medical or hygiene products such as wet tissues, surgical dressings, medical masks, gauze, bandages, medical sheets, medical towels, medical drapes, surgeon gowns, patient clothing, medical caps, medical aprons, medical covers In these products, these products come into direct contact with the skin, mucous membranes or wounds, and when used, absorb liquids secreted, exuded or discharged from the living body, creating an environment in which microorganisms can easily propagate, or Antibacterial properties are considered to be one of the important functions from the viewpoint of prevention of infectious diseases, considering that they are used in medical sites that extremely dislike bacterial contamination such as surgery.
【0003】医療または衛生用品に抗菌性を付与する試
みとして、特開平4−2345号広報には抗菌剤として
塩化ベンザルコニウムを含有する紙おむつが開示されて
いる。特開平5−212094号広報には抗菌剤として
スルホン酸基を導入したポリスチレン樹脂からなる強カ
チオン交換樹脂に銀を担持させた衛生用品が開示されて
いる。特開平9−10296号広報には抗菌剤として塩
酸クロルヘキシジンまたは臭化ドミフェンを含有させた
体液吸収用品が開示されている。特開平9−10826
1号広報には抗菌剤としてシクロデキストリンに包摂し
たフィトンチッドを含有させた衛生生理用品が開示され
ている。特開平11−1895号広報には抗菌剤として
カルボキシメチルセルロースに銀を担持させた衛生用品
が開示されている。特開平11−200245号広報に
はロジンアミン化物を含む植物由来水溶性抽出物を含有
する抗菌シートとそれを構成成分とする衛生用品が開示
されている。[0003] As an attempt to impart antibacterial properties to medical or hygiene articles, Japanese Patent Application Laid-Open No. Hei 4-2345 discloses a disposable diaper containing benzalkonium chloride as an antibacterial agent. JP-A-5-212094 discloses a sanitary article in which silver is supported on a strong cation exchange resin comprising a polystyrene resin having a sulfonic acid group introduced therein as an antibacterial agent. Japanese Patent Application Laid-Open No. 9-10296 discloses a body fluid absorbing article containing chlorhexidine hydrochloride or domiphen bromide as an antibacterial agent. JP-A-9-10826
No. 1 public information discloses a sanitary and sanitary product containing phytontide incorporated in cyclodextrin as an antibacterial agent. Japanese Patent Application Laid-Open No. 11-1895 discloses a sanitary article in which carboxymethyl cellulose carries silver as an antibacterial agent. Japanese Patent Application Laid-Open No. 11-220245 discloses an antibacterial sheet containing a plant-derived water-soluble extract containing a rosin aminated compound and a sanitary article comprising the same as a constituent.
【0004】しかしながら、開示されたこれらの方法に
共通する問題点として、これらが何れも製品の一部に抗
菌性を有する薬剤または金属を含有させたものであり、
またこれらの抗菌成分の含有の様態が混合、付着あるい
はイオン性の結合であるため、生体から分泌、滲出ある
いは排出された液体による溶出、あるいは皮膚、粘膜ま
たは傷口との摩擦による脱落により、アレルギー等の原
因となる可能性が考えられる。[0004] However, a problem common to these disclosed methods is that each of them contains an antibacterial drug or metal in a part of the product,
In addition, since the content of these antimicrobial components is mixed, adhered, or ionically bound, they are allergic due to secretion, exudation from the living body, elution by the exuded liquid, or dropout due to friction with skin, mucous membranes or wounds. May be the cause.
【0005】[0005]
【発明が解決しようとする課題】本発明は、上記の問題
点を有さない抗菌性、安全性に優れた医療または衛生用
品を提供することを目的とする。SUMMARY OF THE INVENTION An object of the present invention is to provide a medical or hygiene article which does not have the above-mentioned problems and has excellent antibacterial properties and safety.
【0006】[0006]
【課題を解決するための手段】本発明者らは、医療また
は衛生用品またはそれらの一部を、それ自体が抗菌性を
持つ塩基性アミノ酸セルロース部分エステル及び/また
はその塩で構成することにより、上記の目的が達成され
ることを見出し、本発明を完成させた。塩基性アミノ酸
セルロース部分エステルは塩基性アミノ酸のカルボキシ
ル基とセルロースの水酸基が共有結合(エステル結合)
した構造になっており、生体から分泌、滲出あるいは排
出された液体による溶出、あるいは皮膚、粘膜または傷
口との摩擦による脱落の可能性は低い。また、エステル
結合が切断された場合にも脱落する成分は生体に対して
無害のアミノ酸であるため、その安全性は極めて高い。
すなわち、本発明は、塩基性アミノ酸セルロース部分エ
ステル及び/またはその塩を構成成分とする医療または
衛生用品である。Means for Solving the Problems The present inventors have made a medical or hygiene article or a part thereof from a basic amino acid cellulose partial ester having antibacterial properties by itself and / or a salt thereof. The inventors have found that the above-mentioned objects are achieved, and have completed the present invention. In basic amino acid cellulose partial ester, the carboxyl group of basic amino acid and the hydroxyl group of cellulose are covalently bonded (ester bond).
It is unlikely to be eluted by a liquid secreted, exuded or discharged from a living body, or to fall off due to friction with skin, mucous membranes or wounds. In addition, since the components that are removed even when the ester bond is cleaved are harmless amino acids to the living body, their safety is extremely high.
That is, the present invention is a medical or hygiene article comprising a basic amino acid cellulose partial ester and / or a salt thereof as a constituent.
【0007】[0007]
【発明の実施の形態】本発明に用いる塩基性アミノ酸セ
ルロース部分エステル及び/またはその塩は、塩基性ア
ミノ酸部分がリジン、アルギニン、オルニチンまたはヒ
スチジン残基であって、それぞれリジンセルロース部分
エステル、アルギニンセルロース部分エステル、オルニ
チンセルロース部分エステルおよびヒスチジンセルロー
ス部分エステルとなる。この場合、塩基性アミノ酸は混
合アミノ酸であっても良い。塩基性アミノ酸セルロース
部分エステル及び/またはその塩のエステル化置換度
は、好ましくは0.0001以上3未満である。また、
塩の種類としては、例えば酢酸塩、乳酸塩、リンゴ酸
塩、酒石酸塩、コハク酸塩、クエン酸塩、安息香酸塩、
ピロリドンカルボン酸塩のような有機酸塩、または塩酸
塩、硫酸塩、リン酸塩のような無機酸塩、またはルイス
酸塩が挙げられる。BEST MODE FOR CARRYING OUT THE INVENTION The basic amino acid cellulose partial ester and / or a salt thereof used in the present invention are those wherein the basic amino acid moiety is a lysine, arginine, ornithine or histidine residue, and the lysine cellulose partial ester and the arginine cellulose, respectively. It becomes a partial ester, an ornithine cellulose partial ester and a histidine cellulose partial ester. In this case, the basic amino acid may be a mixed amino acid. The esterification substitution degree of the basic amino acid cellulose partial ester and / or its salt is preferably 0.0001 or more and less than 3. Also,
Examples of the type of salt include acetate, lactate, malate, tartrate, succinate, citrate, benzoate,
Organic acid salts, such as pyrrolidone carboxylate, or inorganic acid salts, such as hydrochloride, sulfate, phosphate, or Lewis acid salt.
【0008】塩基性アミノ酸セルロース部分エステルは
例えば以下の方法で製造することができる。すなわち、
先ず、セルロースを塩基性アミノ酸エステルを含有する
処理剤液と接触させ、適宜脱液、乾燥する。次いで加熱
処理を行い、その後、未反応の塩基性アミノ酸エステル
等を除くため、洗浄等の後処理を行う。ここで使用され
るセルロースは通常の方法でアルカリ等で前処理されて
いても差し支えない。さらに、加熱処理後の工程に於い
て、任意の酸を用いることにより、塩基性アミノ酸セル
ロース部分エステルを任意の酸の塩とすることができ
る。The basic partial amino acid cellulose ester can be produced, for example, by the following method. That is,
First, cellulose is brought into contact with a treating agent solution containing a basic amino acid ester, and then appropriately drained and dried. Next, a heat treatment is performed, and then a post-treatment such as washing is performed to remove unreacted basic amino acid esters and the like. The cellulose used here may be pretreated with an alkali or the like by a usual method. Furthermore, by using an optional acid in the step after the heat treatment, the basic amino acid cellulose partial ester can be converted to a salt of the optional acid.
【0009】処理剤液としては塩基性アミノ酸エステ
ル、好ましくはメチルエステルに代表される炭素数1乃
至6の低級アルキルエステルを水、アルコールまたはこ
れらの混合物に溶解したものを使用する。塩基性アミノ
酸エステルが塩酸、硫酸等の塩である場合には、必要に
応じて塩基性アミノ酸エステルの10乃至200mol
%の水酸化アルカリ等で中和してもよい。処理剤液中の
含有割合は溶解、分散する範囲であれば任意である。こ
の処理剤液にセルロースを浸漬し、必要に応じて適宜脱
液した後、1乃至数時間風乾または加熱乾燥する。これ
を100乃至200℃、好ましくは120乃至180℃
で1乃至100分間、好ましくは5乃至60分間加熱加
工した後、洗浄、乾燥工程を経て生成物を得る。洗浄は
初めに水、次いで重曹等のアルカリ水溶液およびクエン
酸等の有機酸水溶液、最後に水の順で行うが、一部を適
宜省略することもできる。有機酸水溶液での洗浄時に、
セルロースにエステル結合した塩基性アミノ酸は塩を形
成するため、有機酸水溶液での洗浄を行った場合、製品
は塩基性アミノ酸セルロース部分エステル有機酸塩とし
て得られる。As the treating agent solution, a solution prepared by dissolving a basic amino acid ester, preferably a lower alkyl ester having 1 to 6 carbon atoms typified by a methyl ester, in water, alcohol or a mixture thereof is used. When the basic amino acid ester is a salt such as hydrochloric acid or sulfuric acid, 10 to 200 mol of the basic amino acid ester may be used as necessary.
% Alkali hydroxide or the like. The content ratio in the treatment agent liquid is arbitrary as long as it is in a range in which it is dissolved and dispersed. Cellulose is immersed in this treating agent solution, and, if necessary, is deliquored and then air-dried or heat-dried for 1 to several hours. 100 to 200 ° C, preferably 120 to 180 ° C
For 1 to 100 minutes, preferably 5 to 60 minutes, followed by washing and drying steps to obtain a product. Washing is performed in the order of water, then an aqueous solution of an alkali such as sodium bicarbonate and the like, and an aqueous solution of an organic acid such as citric acid, and finally water. When washing with an organic acid aqueous solution,
Since the basic amino acid ester-bound to cellulose forms a salt, the product is obtained as a basic amino acid cellulose partial ester organic acid salt when washed with an organic acid aqueous solution.
【0010】本発明はかかる塩基性アミノ酸セルロース
部分エステル及び/またはその塩を構成成分とした医療
または衛生用品である。具体的には、その形態が布ある
いは不織布である塩基性アミノ酸セルロース部分エステ
ル及び/またはその塩を、少なくとも製品の一部、特に
皮膚、粘膜または傷口への接触面に配してなるものであ
ればよく、他の部分は従来公知の構造を採用することも
できる。紙おむつ、失禁パッド、生理用ナプキン、生理
用タンポン、パンティシート、汗取りパッド、母乳パッ
ド、医療用タンポン、綿棒、救急絆創膏、サージカルド
レッシングのように生体から分泌、滲出あるいは排出さ
れた液体を吸収する目的を持つ医療または衛生用品の場
合は、塩基性アミノ酸セルロース部分エステル及び/ま
たはその塩に加えて吸収体またはその吸収体の一部に塩
基性アミノ酸セルロース部分エステル及び/またはその
塩を配したものを用いてもよい。この場合、その形態は
必ずしも布あるいは不織布である必要はなく、繊維状ま
たは粉末状であってもよい。The present invention is a medical or sanitary article comprising such a basic amino acid cellulose partial ester and / or a salt thereof as a constituent. Specifically, the basic amino acid cellulose partial ester in the form of a cloth or a non-woven fabric and / or a salt thereof is disposed on at least a part of the product, particularly on the contact surface with the skin, mucous membrane or wound. What is necessary is just to employ | adopt a conventionally well-known structure for another part. The purpose of absorbing liquid excreted, exuded or discharged from living bodies, such as disposable diapers, incontinence pads, sanitary napkins, sanitary tampon, panty sheets, sweat-absorbing pads, breast milk pads, medical tampons, cotton swabs, emergency bandages, and surgical dressings In the case of medical or hygiene products having a basic amino acid cellulose partial ester and / or its salt, in addition to the basic amino acid cellulose partial ester and / or its salt, the absorbent or a part of the absorbent is provided with the basic amino acid cellulose partial ester and / or its salt May be used. In this case, the form does not necessarily need to be a cloth or a nonwoven fabric, but may be a fibrous or powdery form.
【0011】[0011]
【実施例】以下に本発明を実施例により更に詳細に説明
するが、本発明はこれらの例に限定されるものではな
い。EXAMPLES The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.
【0012】製造例1<L−リジンセルロース部分エス
テルクエン酸塩の製造> L−リジンメチルエステル2塩酸塩2.33g(10m
mol)、をメタノール15mlに溶解し、これに2規
定水酸化ナトリウム水溶液5mlを加え処理剤液とし
た。綿不織布(ハニロン株式会社製CX32)5.0g
をこの処理剤液に浸漬し、1時間風乾した後、140℃
で20分間加熱処理した。これを水洗し、さらに5重量
%の重曹水による洗浄および水による濯ぎを3回、10
重量%のクエン酸水溶液による洗浄および水による濯ぎ
を3回繰り返した後、脱水、風乾し試料とした。この試
料の一部を50℃で一夜真空乾燥した後、約0.5gを
正確に秤量し、0.5N水酸化ナトリウム50ml中、
室温で18時間攪拌しアルカリ加水分解した。繊維を濾
別した後、アミノ酸分析機(日立製作所L−8500)
を用いてL−リジンの定量を行った。その結果から試料
1g当たりのL-リジンの結合量を算出したところ、0.
105mmol(エステル化置換度0.017)であっ
た。また、同じ検液中のクエン酸の定量をHPLCを用
いて行った結果から試料1g当たりのクエン酸の結合量
を算出したところ、0.190mmolであった。Production Example 1 <Production of L-Lysine Cellulose Partial Ester Citrate> 2.33 g (10 m) of L-lysine methyl ester dihydrochloride
mol) was dissolved in 15 ml of methanol, and 5 ml of a 2N aqueous sodium hydroxide solution was added thereto to obtain a treating agent liquid. 5.0 g of cotton nonwoven fabric (CX32 manufactured by Hanilon Co., Ltd.)
Was immersed in this treating agent solution and air-dried for 1 hour.
For 20 minutes. This was washed with water, and further washed with 5% by weight aqueous sodium bicarbonate solution and rinsed with water three times, 10 times.
Washing with a weight% citric acid aqueous solution and rinsing with water were repeated three times, followed by dehydration and air drying to obtain a sample. After vacuum-drying a part of this sample at 50 ° C. overnight, about 0.5 g is accurately weighed, and in 50 ml of 0.5N sodium hydroxide,
The mixture was stirred at room temperature for 18 hours to carry out alkali hydrolysis. After filtering the fibers, amino acid analyzer (Hitachi L-8500)
Was used to quantify L-lysine. When the amount of L-lysine bound per 1 g of the sample was calculated from the result, it was found that the amount was 0.1%.
105 mmol (degree of esterification substitution 0.017). The amount of citric acid bound to 1 g of the sample was calculated from the result of quantification of citric acid in the same test solution using HPLC, which was 0.190 mmol.
【0013】製造例2 <L−アルギニンセルロース部
分エステルクエン酸塩の製造> 製造例1のL−リジンメチルエステル2塩酸塩に代えて
L−アルギニンメチルエステル2塩酸塩2.61g(1
0mmol)を使用して同様の実験を行った。製造例1
と同様の方法で試料1g当たりのL−アルギニンの結合
量を算出したところ、0.109mmol(エステル化
置換度0.018)であった。また同様に、クエン酸の
結合量は0.162mmolであった。Production Example 2 <Production of L-arginine cellulose partial ester citrate> In place of L-lysine methyl ester dihydrochloride of Production Example 1, 2.61 g of L-arginine methyl ester dihydrochloride (1)
(0 mmol). Production Example 1
When the amount of L-arginine bound per 1 g of the sample was calculated in the same manner as described above, it was 0.109 mmol (degree of esterification substitution 0.018). Similarly, the binding amount of citric acid was 0.162 mmol.
【0014】実施例1 製造例1のL−リジンセルロース部分エステルクエン酸
塩の不織布、製造例2のL−アルギニンセルロース部分
エステルクエン酸塩の不織布を用いて医療用マスクを作
成した。また、比較品として未加工の不織布を用いて同
様に医療用マスクを作成した。Example 1 A medical mask was prepared using the nonwoven fabric of L-lysine cellulose partial ester citrate of Production Example 1 and the nonwoven fabric of L-arginine cellulose partial ester citrate of Production Example 2. In addition, a medical mask was similarly prepared using an unprocessed nonwoven fabric as a comparative product.
【0015】試験例1 専門パネル5名による官能評価により、これらの医療用
マスクの着装時の使用感を、(1)使用感が非常に悪
い、(2)使用感が悪い、(3)ふつう、(4)使用感
がよい、(5)使用感が非常によい、の5段階にて評価
した。L−リジンおよびL−アルギニンセルロース部分
エステルクエン酸塩の不織布を用いて作成した医療用マ
スクと未加工の不織布を用いて作成した医療用マスクと
の間に、評価点の差はなかった。Test Example 1 Based on sensory evaluations by five professional panels, the feeling of wearing these medical masks when wearing them was as follows: (1) very bad feeling, (2) bad feeling, and (3) ordinary. , (4) good feeling of use, and (5) very good feeling of use. There was no difference in the evaluation points between a medical mask made using a nonwoven fabric of L-lysine and L-arginine cellulose partial ester citrate and a medical mask made using an unprocessed nonwoven fabric.
【0016】試験例2 これらの医療用マスクから一辺約18mmの正方形の切
片を作り、「JISL 1902:1998「繊維製品
の抗菌力試験方法」8.定量試験」に記載された手順に
準じて、抗菌力試験を実施した。試験菌として黄色ブド
ウ球菌(Staphylococcus aureus
ATCC 6538P)および肺炎桿菌(Klebsi
ella pneumoniae ATCC 4352)
を使用した。各検体を高圧蒸気滅菌した後、Nutri
ent Broth培地に懸濁した一定量(約2.5×
104)の菌を接種し、37℃にて18時間培養を行っ
た後、それぞれの生菌数を測定した。結果を表1、表2に
示す。Test Example 2 A square section of about 18 mm on a side was prepared from these medical masks, and the test was performed as described in "JISL 1902: 1998," Testing method for antibacterial activity of textile products ". The antibacterial activity test was performed according to the procedure described in “Quantitative test”. Staphylococcus aureus (Staphylococcus aureus)
ATCC 6538P) and Klebsiella pneumoniae (Klebsi)
ella pneumoniae ATCC 4352)
It was used. After autoclaving each sample, Nutri
ent Broth medium (about 2.5 ×
10 4 ) was inoculated and cultured at 37 ° C. for 18 hours, and the viable cell count of each was measured. The results are shown in Tables 1 and 2.
【0017】また、JIS L 1902:1998記載
の式、F=Mb−Ma、S=Mb−Mc、L=Ma−M
c(但し、F:増殖値、S:静菌活性値、L:殺菌活性
値、Ma:無加工試料の接種直後の生菌数(3試料の平
均)の常用対数、Mb:無加工試料の18時間培養後の
生菌数(3試料の平均)の常用対数値、Mc:加工試料
の18時間培養後の生菌数(3試料の平均)の常用対
数)から増殖値、静菌活性値および殺菌活性値を算出し
た。結果を表1、表2にあわせて示す。Further, JIS L 1902: Formula 1998 wherein, F = M b -M a, S = M b -M c, L = M a -M
c (where, F: growth value, S: bacteriostatic activity value, L: bactericidal activity value, M a: common logarithm of the number of living bacteria immediately after inoculation of non-processed sample (average of three samples), M b: unprocessed common logarithm of 18 hours viable cell count after culturing of the sample (average of three samples), M c: proliferation values from logarithm) of viable counts after 18 hours incubation of the processed sample (average of three samples), static Bacterial activity values and bactericidal activity values were calculated. The results are shown in Tables 1 and 2.
【0018】[0018]
【表1】 【table 1】
【0019】[0019]
【表2】 [Table 2]
【0020】これらの試験により、L−リジンおよびL
−アルギニンセルロース部分エステルクエン酸塩不織布
を用いて作成した医療用マスクが充分な抗菌性を示すこ
とが確認された。These tests show that L-lysine and L-lysine
-It was confirmed that the medical mask prepared using the arginine cellulose partial ester citrate nonwoven fabric exhibited sufficient antibacterial properties.
【0021】試験例3 実施例1で作成したL−リジンセルロース部分エステル
クエン酸塩の不織布を用いた医療用マスクの切片0.4
22gを10mlの水中、室温にて震盪することによ
り、溶出試験を行った。HPLCを用いて溶出された成
分を分析した結果、切片1gに付いて1時間後に0.0
098mmol、5時間後に0.0130mmolのL
−リジンの溶出が認められた。L−リジン以外の溶出物
は認められなかった。Test Example 3 A section of a medical mask using the non-woven fabric of L-lysine cellulose partial ester citrate prepared in Example 1 0.4
The dissolution test was performed by shaking 22 g at room temperature in 10 ml of water. As a result of analyzing the eluted components using HPLC, 1 hour after 1 hour, 1
098 mmol, 0.0130 mmol L after 5 hours
-Elution of lysine was observed. No eluate other than L-lysine was observed.
【0022】[0022]
【発明の効果】本発明により、塩基性アミノ酸セルロー
ス部分エステル及び/またはその塩を構成成分とする、
抗菌性、安全性に優れた医療または衛生用品を提供する
ことが可能となった。According to the present invention, a basic amino acid cellulose partial ester and / or a salt thereof is used as a constituent.
It has become possible to provide medical or hygiene articles excellent in antibacterial properties and safety.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 FI テーマコート゛(参考) A61F 5/44 A61F 13/20 321 4L047 13/14 A61L 2/16 Z 13/20 321 D04H 1/42 Z A61L 2/16 A61F 13/18 381 15/58 A61L 15/06 A61F 13/36 A61M 35/00 X D04H 1/42 A41B 13/02 N // A61F 13/49 Fターム(参考) 3B029 BA12 BD22 4C003 AA19 HA02 4C058 AA03 AA12 BB07 JJ02 4C081 AA03 AA12 BA14 CD021 CD32 CE11 4C098 AA09 CC01 DD10 DD21 4L047 AA08 AB02 CB10 CC03 CC05──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A61F 5/44 A61F 13/20 321 4L047 13/14 A61L 2/16 Z 13/20 321 D04H 1/42 Z A61L 2/16 A61F 13/18 381 15/58 A61L 15/06 A61F 13/36 A61M 35/00 X D04H 1/42 A41B 13/02 N // A61F 13/49 F term (reference) 3B029 BA12 BD22 4C003 AA19 HA02 4C058 AA03 AA12 BB07 JJ02 4C081 AA03 AA12 BA14 CD021 CD32 CE11 4C098 AA09 CC01 DD10 DD21 4L047 AA08 AB02 CB10 CC03 CC05
Claims (4)
び/またはその塩を構成成分とする医療または衛生用
品。1. A medical or hygiene product comprising a basic amino acid cellulose partial ester and / or a salt thereof as a constituent.
ロース部分エステル及び/またはその塩を構成成分とす
る請求項1記載の医療または衛生用品。2. The medical or hygiene article according to claim 1, which comprises a basic amino acid cellulose partial ester in which the cellulose is cotton and / or a salt thereof.
び/またはその塩の形態が布あるいは不織布である請求
項1または2記載の医療または衛生用品。3. The medical or sanitary article according to claim 1, wherein the form of the basic amino acid cellulose partial ester and / or its salt is a cloth or a nonwoven fabric.
生理用タンポン、パンティシート、汗取りパッド、母乳
パッド、医療用タンポン、綿棒、救急絆創膏、ウエット
ティッシュー、サージカルドレッシング、医療用マス
ク、ガーゼ、包帯、医療用シーツ、医療用タオル、医療
用ドレープ、術者用ガウン、患者衣、医療用キャップ、
医療用エプロン、医療用カバーからなる群から選択され
る医療または衛生用品である請求項1乃至3記載の医療
または衛生用品。4. A disposable diaper, an incontinence pad, a sanitary napkin,
Sanitary tampons, panty sheets, sweat pads, breast pads, medical tampons, cotton swabs, first aid plasters, wet tissues, surgical dressings, medical masks, gauze, bandages, medical sheets, medical towels, medical drapes, surgeons Gowns, patient clothing, medical caps,
4. The medical or sanitary article according to claim 1, which is a medical or sanitary article selected from the group consisting of a medical apron and a medical cover.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000159774A JP2001340378A (en) | 2000-05-30 | 2000-05-30 | Medical or sanitary article |
US10/296,217 US20040083556A1 (en) | 2000-05-30 | 2001-05-29 | Fiber product having antibacterial and deodorant function |
KR1020027016238A KR20030005433A (en) | 2000-05-30 | 2001-05-29 | Fiber product having antibacterial and deodorant function |
EP01932316A EP1291460A4 (en) | 2000-05-30 | 2001-05-29 | Fiber product having antibacterial and deodorant function |
CN01810541A CN1432085A (en) | 2000-05-30 | 2001-05-29 | Fiber product having antibacterial and deodorant function |
PCT/JP2001/004493 WO2001092632A1 (en) | 2000-05-30 | 2001-05-29 | Fiber product having antibacterial and deodorant function |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000159774A JP2001340378A (en) | 2000-05-30 | 2000-05-30 | Medical or sanitary article |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001340378A true JP2001340378A (en) | 2001-12-11 |
Family
ID=18664057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000159774A Pending JP2001340378A (en) | 2000-05-30 | 2000-05-30 | Medical or sanitary article |
Country Status (2)
Country | Link |
---|---|
US (1) | US20040083556A1 (en) |
JP (1) | JP2001340378A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003007702A1 (en) * | 2001-07-10 | 2003-01-30 | Ajinomoto Co., Inc. | Materials for feeding animals |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040048532A1 (en) * | 2002-08-14 | 2004-03-11 | Tharreau Industries | Nonwoven substrate which can give off an aroma and/or a flavor |
CA2684150C (en) * | 2007-05-14 | 2016-10-04 | Research Foundation Of State University Of New York | Decenoic acid dispersion inducers in the treatment of biofilms |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3728213A (en) * | 1971-08-18 | 1973-04-17 | American Cyanamid Co | Antibiotic paper |
JPS5212396A (en) * | 1975-07-16 | 1977-01-29 | Toyo Boseki | Treating method of fiber article |
JPH0787587B2 (en) * | 1990-02-16 | 1995-09-20 | 松下電器産業株式会社 | Gradation correction device |
IL113534A0 (en) * | 1995-04-28 | 1995-07-31 | Shenkar College Textile Tech | Microbistatic and deodorizing of cellulose fibers |
AU729836B2 (en) * | 1995-12-29 | 2001-02-08 | University Of Arkansas, The | Peanut allergens and methods |
AU1894901A (en) * | 1999-12-21 | 2001-07-03 | Ajinomoto Co., Inc. | Partial ester of cellulose with nitrogenous carboxylic acid and process for producing the same |
JP3637892B2 (en) * | 2001-11-16 | 2005-04-13 | 味の素株式会社 | Antibacterial packaging material |
-
2000
- 2000-05-30 JP JP2000159774A patent/JP2001340378A/en active Pending
-
2001
- 2001-05-29 US US10/296,217 patent/US20040083556A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003007702A1 (en) * | 2001-07-10 | 2003-01-30 | Ajinomoto Co., Inc. | Materials for feeding animals |
Also Published As
Publication number | Publication date |
---|---|
US20040083556A1 (en) | 2004-05-06 |
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