JP2001340378A - Medical or sanitary article - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medical or sanitary article having excellent antibacterial and safety. SOLUTION: The medical or sanitary article comprises a basic amino acid cellulose partial ester and/or its salt as constituents.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to medical or hygiene articles excellent in antibacterial properties and safety. More particularly, the present invention relates to medical or hygiene products comprising a basic amino acid cellulose partial ester and / or a salt thereof.

[0002]

2. Description of the Related Art In recent years, a number of new antibacterial products have been put on the market in various fields against the background of the social problem of infection by methicillin-resistant Staphylococcus aureus (MRSA) and pathogenic Escherichia coli O-157. Disposable diapers, incontinence pads, sanitary napkins, sanitary tampons, panty sheets, sweat-absorbing pads, breastfeeding pads, medical tampons, cotton swabs, first aid plasters,
Medical or hygiene products such as wet tissues, surgical dressings, medical masks, gauze, bandages, medical sheets, medical towels, medical drapes, surgeon gowns, patient clothing, medical caps, medical aprons, medical covers In these products, these products come into direct contact with the skin, mucous membranes or wounds, and when used, absorb liquids secreted, exuded or discharged from the living body, creating an environment in which microorganisms can easily propagate, or Antibacterial properties are considered to be one of the important functions from the viewpoint of prevention of infectious diseases, considering that they are used in medical sites that extremely dislike bacterial contamination such as surgery.

[0003] As an attempt to impart antibacterial properties to medical or hygiene articles, Japanese Patent Application Laid-Open No. Hei 4-2345 discloses a disposable diaper containing benzalkonium chloride as an antibacterial agent. JP-A-5-212094 discloses a sanitary article in which silver is supported on a strong cation exchange resin comprising a polystyrene resin having a sulfonic acid group introduced therein as an antibacterial agent. Japanese Patent Application Laid-Open No. 9-10296 discloses a body fluid absorbing article containing chlorhexidine hydrochloride or domiphen bromide as an antibacterial agent. JP-A-9-10826
No. 1 public information discloses a sanitary and sanitary product containing phytontide incorporated in cyclodextrin as an antibacterial agent. Japanese Patent Application Laid-Open No. 11-1895 discloses a sanitary article in which carboxymethyl cellulose carries silver as an antibacterial agent. Japanese Patent Application Laid-Open No. 11-220245 discloses an antibacterial sheet containing a plant-derived water-soluble extract containing a rosin aminated compound and a sanitary article comprising the same as a constituent.

[0004] However, a problem common to these disclosed methods is that each of them contains an antibacterial drug or metal in a part of the product,
In addition, since the content of these antimicrobial components is mixed, adhered, or ionically bound, they are allergic due to secretion, exudation from the living body, elution by the exuded liquid, or dropout due to friction with skin, mucous membranes or wounds. May be the cause.

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to provide a medical or hygiene article which does not have the above-mentioned problems and has excellent antibacterial properties and safety.

[0006]

Means for Solving the Problems The present inventors have made a medical or hygiene article or a part thereof from a basic amino acid cellulose partial ester having antibacterial properties by itself and / or a salt thereof. The inventors have found that the above-mentioned objects are achieved, and have completed the present invention. In basic amino acid cellulose partial ester, the carboxyl group of basic amino acid and the hydroxyl group of cellulose are covalently bonded (ester bond).
It is unlikely to be eluted by a liquid secreted, exuded or discharged from a living body, or to fall off due to friction with skin, mucous membranes or wounds. In addition, since the components that are removed even when the ester bond is cleaved are harmless amino acids to the living body, their safety is extremely high.
That is, the present invention is a medical or hygiene article comprising a basic amino acid cellulose partial ester and / or a salt thereof as a constituent.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The basic amino acid cellulose partial ester and / or a salt thereof used in the present invention are those wherein the basic amino acid moiety is a lysine, arginine, ornithine or histidine residue, and the lysine cellulose partial ester and the arginine cellulose, respectively. It becomes a partial ester, an ornithine cellulose partial ester and a histidine cellulose partial ester. In this case, the basic amino acid may be a mixed amino acid. The esterification substitution degree of the basic amino acid cellulose partial ester and / or its salt is preferably 0.0001 or more and less than 3. Also,
Examples of the type of salt include acetate, lactate, malate, tartrate, succinate, citrate, benzoate,
Organic acid salts, such as pyrrolidone carboxylate, or inorganic acid salts, such as hydrochloride, sulfate, phosphate, or Lewis acid salt.

The basic partial amino acid cellulose ester can be produced, for example, by the following method. That is,
First, cellulose is brought into contact with a treating agent solution containing a basic amino acid ester, and then appropriately drained and dried. Next, a heat treatment is performed, and then a post-treatment such as washing is performed to remove unreacted basic amino acid esters and the like. The cellulose used here may be pretreated with an alkali or the like by a usual method. Furthermore, by using an optional acid in the step after the heat treatment, the basic amino acid cellulose partial ester can be converted to a salt of the optional acid.

As the treating agent solution, a solution prepared by dissolving a basic amino acid ester, preferably a lower alkyl ester having 1 to 6 carbon atoms typified by a methyl ester, in water, alcohol or a mixture thereof is used. When the basic amino acid ester is a salt such as hydrochloric acid or sulfuric acid, 10 to 200 mol of the basic amino acid ester may be used as necessary.
% Alkali hydroxide or the like. The content ratio in the treatment agent liquid is arbitrary as long as it is in a range in which it is dissolved and dispersed. Cellulose is immersed in this treating agent solution, and, if necessary, is deliquored and then air-dried or heat-dried for 1 to several hours. 100 to 200 ° C, preferably 120 to 180 ° C
For 1 to 100 minutes, preferably 5 to 60 minutes, followed by washing and drying steps to obtain a product. Washing is performed in the order of water, then an aqueous solution of an alkali such as sodium bicarbonate and the like, and an aqueous solution of an organic acid such as citric acid, and finally water. When washing with an organic acid aqueous solution,
Since the basic amino acid ester-bound to cellulose forms a salt, the product is obtained as a basic amino acid cellulose partial ester organic acid salt when washed with an organic acid aqueous solution.

The present invention is a medical or sanitary article comprising such a basic amino acid cellulose partial ester and / or a salt thereof as a constituent. Specifically, the basic amino acid cellulose partial ester in the form of a cloth or a non-woven fabric and / or a salt thereof is disposed on at least a part of the product, particularly on the contact surface with the skin, mucous membrane or wound. What is necessary is just to employ | adopt a conventionally well-known structure for another part. The purpose of absorbing liquid excreted, exuded or discharged from living bodies, such as disposable diapers, incontinence pads, sanitary napkins, sanitary tampon, panty sheets, sweat-absorbing pads, breast milk pads, medical tampons, cotton swabs, emergency bandages, and surgical dressings In the case of medical or hygiene products having a basic amino acid cellulose partial ester and / or its salt, in addition to the basic amino acid cellulose partial ester and / or its salt, the absorbent or a part of the absorbent is provided with the basic amino acid cellulose partial ester and / or its salt May be used. In this case, the form does not necessarily need to be a cloth or a nonwoven fabric, but may be a fibrous or powdery form.

[0011]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

Production Example 1 <Production of L-Lysine Cellulose Partial Ester Citrate> 2.33 g (10 m) of L-lysine methyl ester dihydrochloride
mol) was dissolved in 15 ml of methanol, and 5 ml of a 2N aqueous sodium hydroxide solution was added thereto to obtain a treating agent liquid. 5.0 g of cotton nonwoven fabric (CX32 manufactured by Hanilon Co., Ltd.)
Was immersed in this treating agent solution and air-dried for 1 hour.
For 20 minutes. This was washed with water, and further washed with 5% by weight aqueous sodium bicarbonate solution and rinsed with water three times, 10 times.
Washing with a weight% citric acid aqueous solution and rinsing with water were repeated three times, followed by dehydration and air drying to obtain a sample. After vacuum-drying a part of this sample at 50 ° C. overnight, about 0.5 g is accurately weighed, and in 50 ml of 0.5N sodium hydroxide,
The mixture was stirred at room temperature for 18 hours to carry out alkali hydrolysis. After filtering the fibers, amino acid analyzer (Hitachi L-8500)
Was used to quantify L-lysine. When the amount of L-lysine bound per 1 g of the sample was calculated from the result, it was found that the amount was 0.1%.
105 mmol (degree of esterification substitution 0.017). The amount of citric acid bound to 1 g of the sample was calculated from the result of quantification of citric acid in the same test solution using HPLC, which was 0.190 mmol.

Production Example 2 <Production of L-arginine cellulose partial ester citrate> In place of L-lysine methyl ester dihydrochloride of Production Example 1, 2.61 g of L-arginine methyl ester dihydrochloride (1)
(0 mmol). Production Example 1
When the amount of L-arginine bound per 1 g of the sample was calculated in the same manner as described above, it was 0.109 mmol (degree of esterification substitution 0.018). Similarly, the binding amount of citric acid was 0.162 mmol.

Example 1 A medical mask was prepared using the nonwoven fabric of L-lysine cellulose partial ester citrate of Production Example 1 and the nonwoven fabric of L-arginine cellulose partial ester citrate of Production Example 2. In addition, a medical mask was similarly prepared using an unprocessed nonwoven fabric as a comparative product.

Test Example 1 Based on sensory evaluations by five professional panels, the feeling of wearing these medical masks when wearing them was as follows: (1) very bad feeling, (2) bad feeling, and (3) ordinary. , (4) good feeling of use, and (5) very good feeling of use. There was no difference in the evaluation points between a medical mask made using a nonwoven fabric of L-lysine and L-arginine cellulose partial ester citrate and a medical mask made using an unprocessed nonwoven fabric.

Test Example 2 A square section of about 18 mm on a side was prepared from these medical masks, and the test was performed as described in "JISL 1902: 1998," Testing method for antibacterial activity of textile products ". The antibacterial activity test was performed according to the procedure described in “Quantitative test”. Staphylococcus aureus (Staphylococcus aureus)
ATCC 6538P) and Klebsiella pneumoniae (Klebsi)
ella pneumoniae ATCC 4352)
It was used. After autoclaving each sample, Nutri
ent Broth medium (about 2.5 ×
10 ⁴ ) was inoculated and cultured at 37 ° C. for 18 hours, and the viable cell count of each was measured. The results are shown in Tables 1 and 2.

Further, JIS L 1902: Formula 1998 _{wherein, F = M b -M a,} S = M b -M c, L = M a -M
_c (where, F: growth value, S: bacteriostatic activity value, L: bactericidal activity value, _{M a:} common logarithm of the number of living bacteria immediately after inoculation of non-processed sample (average of three samples), _{M b:} unprocessed common logarithm of 18 hours viable cell count after culturing of the sample (average of three samples), M _c: proliferation values from logarithm) of viable counts after 18 hours incubation of the processed sample (average of three samples), static Bacterial activity values and bactericidal activity values were calculated. The results are shown in Tables 1 and 2.

[0018]

【table 1】

[0019]

[Table 2]

These tests show that L-lysine and L-lysine
-It was confirmed that the medical mask prepared using the arginine cellulose partial ester citrate nonwoven fabric exhibited sufficient antibacterial properties.

Test Example 3 A section of a medical mask using the non-woven fabric of L-lysine cellulose partial ester citrate prepared in Example 1 0.4
The dissolution test was performed by shaking 22 g at room temperature in 10 ml of water. As a result of analyzing the eluted components using HPLC, 1 hour after 1 hour, 1
098 mmol, 0.0130 mmol L after 5 hours
-Elution of lysine was observed. No eluate other than L-lysine was observed.

[0022]

According to the present invention, a basic amino acid cellulose partial ester and / or a salt thereof is used as a constituent.
It has become possible to provide medical or hygiene articles excellent in antibacterial properties and safety.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61F 5/44 A61F 13/20 321 4L047 13/14 A61L 2/16 Z 13/20 321 D04H 1/42 Z A61L 2/16 A61F 13/18 381 15/58 A61L 15/06 A61F 13/36 A61M 35/00 X D04H 1/42 A41B 13/02 N // A61F 13/49 F term (reference) 3B029 BA12 BD22 4C003 AA19 HA02 4C058 AA03 AA12 BB07 JJ02 4C081 AA03 AA12 BA14 CD021 CD32 CE11 4C098 AA09 CC01 DD10 DD21 4L047 AA08 AB02 CB10 CC03 CC05

Claims (4)

[Claims] 1. A medical or hygiene product comprising a basic amino acid cellulose partial ester and / or a salt thereof as a constituent. 2. The medical or hygiene article according to claim 1, which comprises a basic amino acid cellulose partial ester in which the cellulose is cotton and / or a salt thereof. 3. The medical or sanitary article according to claim 1, wherein the form of the basic amino acid cellulose partial ester and / or its salt is a cloth or a nonwoven fabric. 4. A disposable diaper, an incontinence pad, a sanitary napkin,
Sanitary tampons, panty sheets, sweat pads, breast pads, medical tampons, cotton swabs, first aid plasters, wet tissues, surgical dressings, medical masks, gauze, bandages, medical sheets, medical towels, medical drapes, surgeons Gowns, patient clothing, medical caps,
4. The medical or sanitary article according to claim 1, which is a medical or sanitary article selected from the group consisting of a medical apron and a medical cover.