JP4679854B2 - Sterilized bamboo fiber gauze - Google Patents

Sterilized bamboo fiber gauze Download PDF

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JP4679854B2
JP4679854B2 JP2004249338A JP2004249338A JP4679854B2 JP 4679854 B2 JP4679854 B2 JP 4679854B2 JP 2004249338 A JP2004249338 A JP 2004249338A JP 2004249338 A JP2004249338 A JP 2004249338A JP 4679854 B2 JP4679854 B2 JP 4679854B2
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bamboo fiber
sterilized
fiber gauze
gauze
polyethylene glycol
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JP2006043370A (en
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雅彦 相田
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株式会社ナファ生活研究所
上海高科生物工程有限公司
上海天竹紡績繊維有限公司
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Description

本発明は竹繊維を原料として作られたガーゼ(すなわち、竹繊維ガーゼに関するものであり、具体的には殺菌溶解液を含有する殺菌性を有する竹繊維ガーゼに関するものである。 The invention gauze (i.e., bamboo fiber gauze) made of bamboo fiber as raw material all SANYO relates, specifically, to a bamboo fiber gauze with a bactericidal containing sterilizing solution.

現在、臨床上皮膚科、外科、救急診療室等でよく使われているガーゼとしては一般的に以下のものがある
(1)普通の医薬用滅菌ガーゼしかしそのもの自体には抗菌性がなく抗癒着性もない
(2)竹繊維を原料として作られた抗癒着性ガーゼ。傷口の癒着が防止できるが、あらゆる細菌に対し殺菌作用がある訳ではない。(特許文献1(CN 1461827A『天然抗菌材料及びその用途』)、特許文献2(特開2003−310721号公報『竹繊維製抗菌性布帛』)参照。)
(3)従来の抗菌性ガーゼ。このものは抗菌物質を含有しているため、殺菌効果があり、傷口の治療または創傷面の感染防止ができるが、傷口または創傷面の抗癒着性の問題は解決できない。(特許文献3(CN 1360949A)『溶解ブドウ球菌複合酵素殺菌ガーゼ』)参照。)この殺菌ガーゼは非常に優れた殺菌効果があるが、創傷面での癒着問題があるので、患者に苦痛をもたらす可能性がある。
Currently, clinical dermatology, surgical, general, there are the following ones as gauze, which is often used in the emergency department room or the like.
(1) Ordinary pharmaceutical sterilized gauze . However , it itself has no antibacterial properties and no anti-adhesion properties .
(2) Anti-adhesive gauze made from bamboo fiber . Wound adhesion can be prevented, but not all bacteria are bactericidal . (Patent Document 1 (CN 1461827A "natural antimicrobial material and use thereof"), Patent Document 2 (JP 2003-310721 JP "bamboo textile antibacterial fabric") reference.)
(3) Conventional antibacterial gauze . Since it contains an antibacterial substance, it has a bactericidal effect and can treat the wound or prevent infection of the wound surface, but cannot solve the problem of anti-adhesion of the wound or wound surface . ( Patent Document 3 (CN 1360949A) “dissolved staphylococcal complex enzyme bactericidal gauze” ). ) This bactericidal gauze has a very good bactericidal effect, but it can cause pain to the patient due to adhesion problems on the wound surface.

CN 1461827ACN 1461827A 特開2003−310721号公報JP 2003-310721 A CN 1360949ACN 1360949A

本発明は殺菌竹繊維ガーゼ及びその製造方法と応用を提供して、従来の殺菌ガーゼに付随していた創傷面での癒着問題を解決することを技術的課題とする。 An object of the present invention is to provide a sterilized bamboo fiber gauze and a manufacturing method and application thereof, and to solve the problem of adhesion on a wound surface associated with a conventional sterilized gauze .

本発明は、殺菌原液の組成分及びその重量パーセンテージが、
溶解ブドウ球菌酵素 0.001−1%
溶解菌酵素 0.1−20%
タンパク質安定剤 0.2−50%
イオン化合物 0.5−10%
水 他
からなり、
前記タンパク質安定剤は、キトサン、ポリエチレングリコール400、ポリエチレングリコール1000、ポリエチレングリコール4000或いはポリエチレングリコール6000の中の一種或いは二種以上であり、
前記イオン化合物は塩化ナトリウム、塩化カリウム、リン酸カリウム或いはリン酸ナトリウムの中の一種或いは二種以上であり、
竹繊維ガーゼが前記殺菌原液を含有していることを特徴とする殺菌竹繊維ガーゼにより上述の課題を達成する。
In the present invention, the composition of the sterilization stock solution and its weight percentage are
Dissolved staphylococcal enzyme 0.001-1%
Lysis enzyme 0.1-20%
Protein stabilizer 0.2-50%
Ionic compounds 0.5-10%
Water and others
Consists of
The protein stabilizer is one or more of chitosan, polyethylene glycol 400, polyethylene glycol 1000, polyethylene glycol 4000 or polyethylene glycol 6000,
The ionic compound is one or more of sodium chloride, potassium chloride, potassium phosphate or sodium phosphate,
The above-mentioned problem is achieved by a sterilized bamboo fiber gauze characterized in that the bamboo fiber gauze contains the sterilized stock solution.

本発明に係る殺菌竹繊維ガーゼによれば、創傷面での抗癒着性を発現し、患者には癒着による苦痛を与えず、創傷面の治癒時間の大幅短縮ができる。 According to the sterilized bamboo fiber gauze according to the present invention , the anti-adhesion property on the wound surface is expressed, the patient is not caused by the adhesion pain, and the healing time of the wound surface can be greatly shortened.

本発明における殺菌原液の最適な浸し量は、4枚あわせ竹繊維ガーゼ100cm 当たり4−6mlである
本発明における殺菌原液の組成分及び重量パーセンテージは以下の通である
溶解ブドウ球菌酵素 0.001−1%
溶解菌酵素 0.1−20%
タンパク質安定剤 0.2−50%
イオン化合物 0.5−10%
水 他
より好ましくは、本発明の殺菌原液の組成分及び重量パーセンテージは以下の通りである
溶解ブドウ球菌酵素 0.01−0.1%
溶解菌酵素 2−10%
タンパク質安定剤 5−40%
イオン化合物 0.5−1%
水 他
上記タンパク質安定剤はキトサン、ポリエチレングリコール400、ポリエチレングリコール1000、ポリエチレングリコール4000或いはポリエチレングリコール6000の中の一種或いは種以上である。
また、上記イオン化合物は塩化ナトリウム、塩化カリウム、リン酸カリウム或いはリン酸ナトリウムの中の一種或いは種以上である。
The optimal amount of sterilization stock solution in the present invention is 4-6 ml per 100 cm 2 of bamboo fiber gauze .
The composition fraction and weight percentage of sterilizing concentrate of the present invention is Ri following passage.
Dissolved staphylococcal enzyme 0.001-1%
Lysis enzyme 0.1-20%
Protein stabilizer 0.2-50%
Ionic compounds 0.5-10%
Water and others .
More preferably, the composition and weight percentage of the sterilization stock solution of the present invention are as follows .
Dissolved staphylococcal enzyme 0.01-0.1%
Lysis enzyme 2-10%
Protein stabilizer 5-40%
Ionic compounds 0.5-1%
Water and others .
The protein stabilizers, chitosan, polyethylene glycol 400, polyethylene glycol 1000, is one or two or more of the polyethylene glycol 4000 or polyethylene glycol 6000.
Further, the ionic compound is sodium chloride, potassium chloride, one of: potassium phosphate or sodium phosphate, or two or more kinds.

本発明の殺菌竹繊維ガーゼの製造に際しては、竹繊維ガーゼを上記殺菌原液の中に浸す。4枚あわせの竹繊維ガーゼ100cm 当たり1−10mlの殺菌原液を含有させる。 The production of the sterilizing bamboo fiber gauze of the present invention, soaking the bamboo fiber gauze into the sterilization stock. 1-10 ml of sterilization stock solution is contained per 100 cm 2 of 4 pieces of bamboo fiber gauze .

本発明の殺菌竹繊維ガーゼは、創傷面傷当て材、またはベビー用または大人用紙オムツ、ナプキン、マスクなどの衛生材料全般に活用できるものであり、竹繊維ガーゼは織物編物、不織布として作ることができる。 Sterilization bamboo fiber gauze of the present invention, the wound surface scratches against material, or a baby or adult for Kamio diaper, napkin, which can be utilized for sanitary materials in general, such as a mask, bamboo fiber gauze fabric, knitted fabric, as non-woven fabric Can be made.

本発明に使用される竹繊維ガーゼは日本の株式会社ナファ生活研究所または中国上海天竹紡績繊維有限公司が生産する竹繊維ガーゼによるものである。 Bamboo fiber gauze to be used in the present invention is, Japan Co., Ltd. Nafa living laboratory or China Shanghai guinea Textile Textile Co., Ltd is due to bamboo fiber gauze to produce.

本発明に使用される溶解ブドウ球菌酵素は中国上海高科生物工程有限公司が生産したものまたは米国SIGMA社から購入する溶解ブドウ球菌酵素によるものである。 The lytic staphylococcal enzyme used in the present invention is one produced by Shanghai High Science Biological Process Co., Ltd. , China, or by lytic staphylococcal enzyme purchased from SIGMA, USA.

本発明による殺菌竹繊維ガーゼには非常に優れた殺菌効果を持っており、体外でよく見かける細菌菌株を使って5分間の実験をした(実験方法は2002年第四版《消毒技術規範》を参照)、実験結果は以下の通である
The sterilized bamboo fiber gauze according to the present invention has a very excellent sterilizing effect, and a five-minute experiment was conducted using bacterial strains often found outside the body. reference), the experimental results are Ri following through.

そのほか臨床で採集した2種類の良く見かける耐薬性菌菌株(黄色ブドウ球菌と緑膿菌)を使って上述と同じように5分間の殺菌実験を行い、殺菌率はそれぞれ99.95%と99.96%であった。
また、中国上海長海医院やけど科で20例の創傷面細菌感染の患者に対して、臨床テストを行い、殺菌竹繊維ガーゼが創傷面感染菌に対する殺菌効果と殺菌竹繊維ガーゼが創傷面傷口に対する癒着性を観察した、結果は以下の通である
やけど創傷面に多く存在する菌株はメチシリン耐性黄色ブドウ球菌(MRSA)、緑膿菌、肺炎桿菌、アシネトバクター菌、Citro Bacter菌とカンジタ菌であり、普通の医薬用ガーゼに5%のSulfamylon溶解液に浸して対照テストとし、実験前とガーゼを使用後72時間後創傷面にてサンプルを採集して、細菌を培養し、実験前後の殺菌率を比較し、結果は以下の通りである。
上記の結果から判るように、本発明の殺菌竹繊維ガーゼは従来のやけど科で使われているSulfamylonガーゼより優れた殺菌効果をもっている。
In addition, sterilization experiments were conducted for 5 minutes in the same manner as described above using two types of commonly observed drug-resistant strains (Staphylococcus aureus and Pseudomonas aeruginosa) collected clinically, and the sterilization rates were 99.95% and 99.95 respectively. It was 96%.
In addition, a clinical test was conducted on 20 wound surface bacterial infection patients in Changhai Clinic, Shanghai, China. Bactericidal bamboo fiber gauze was effective against bacterial wound infection bacteria and bactericidal bamboo fiber gauze was effective against wound wounds. was observed adhesion results are Ri following passage.
The most common strains on burn wounds are methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter, Citro Bacter and Candida. As a control test, the sample was collected on the wound surface before the experiment and 72 hours after using the gauze, the bacteria were cultured, and the sterilization rate before and after the experiment was compared. The results are as follows.
As can be seen from the above results, the sterilized bamboo fiber gauze of the present invention has a sterilizing effect superior to the Sulfamylon gauze used in the conventional burn family.

図1および図2に示すように、竹繊維と綿繊維とでは構造上異なっている。綿繊維は中空状であるのに対し、図2に示すように、竹繊維は表面は溝状であり、竹繊維の表面には多数の凹凸がある。綿繊維はその中空部分で水分を吸収するに対し、竹繊維は表面の溝の部分で水分を吸収すると同時に、竹繊維表面の凹凸が皮膚とガーゼの間の『クッション材』となる。したがって、竹繊維は傷口に対して抗癒着の働きがあり、本発明の殺菌竹繊維ガーゼはガーゼを取り替える際の患者の苦痛を和らげる効果があり、傷口の回復にも有利である。
本発明普通の医薬用綿ガーゼと本発明の殺菌竹繊維ガーゼを使って創傷面に対する癒着性の比較臨床テストを行った
普通の医薬用綿ガーゼ創傷面に使っている場合には、ガーゼを取り替える際患者に苦痛を与え、治りかけの傷口またはその一部は再び開き、傷口の治癒には本来の治癒以上の時間を要した。
これに対して、本発明の殺菌竹繊維ガーゼは竹繊維の特殊性能により、ガーゼは創傷面と癒着せず、患者には苦痛を与えることなく、創傷面の治癒時間の大幅短縮ができる。
臨床観察の中で、いかなる不良反応なかったことから、本発明の殺菌竹繊維ガーゼは治療の効果が良く、患者に対し刺激性等の毒性副作用がなく、臨床で幅広く応用できることが立証された。以下はその実施例である。
As shown in FIGS. 1 and 2, bamboo fiber and cotton fiber are structurally different. The cotton fiber is hollow , whereas the bamboo fiber has a groove shape as shown in FIG. 2 , and the surface of the bamboo fiber has a number of irregularities . Cotton fibers whereas absorbs water in its hollow portion, bamboo fiber and simultaneously absorbs moisture in the groove of the surface irregularities of the bamboo fiber surface becomes "cushion material" between the skin and the gauze. Therefore, bamboo fiber has an anti-adhesion action on the wound, and the sterilized bamboo fiber gauze of the present invention has an effect of relieving the patient's pain when replacing the gauze, and is advantageous for recovery of the wound.
The present inventor uses the usual sterilization bamboo fiber gauze pharmaceutical cotton gauze and the present invention was performed adhesion of controlled clinical tests on wound surface.
In the case where an ordinary pharmaceutical cotton gauze are using the wound surface, the pain and distress to the patient when to replace the gauze, of over a period of healing open wound, or a portion thereof again, the wound healing more than the original healing It took time.
In contrast, the sterilized bamboo fiber gauze special performance of bamboo fiber of the present invention, gauze without adhesion with the wound surface, without Rukoto the pain and distress to the patient, can considerably shorten the healing time of the wound surface.
Among the clinical observations, since there was no any adverse reactions, sterilized bamboo fiber gauze present invention has good effects of treatment, without any toxic side effects, such as irritation to the patient, is established that can be widely applied in clinical It was . The following is an example.

実施例1
溶解ブドウ球菌酵素 0.001グラム
溶解菌酵素 3グラム
キトサン 10グラム
塩化ナトリウム 0.9グラム
水 他
100mlの殺菌原液を作り、14cm×7cmの4枚あわせの竹繊維ガーゼを5mlの殺菌原液の中に浸し、これを皮膚科、外科、産婦人科等身体表面の創傷面の診療科で、創傷面の細菌と真菌の感染の予防または治療に使った。創傷面の治癒を促進し、治療時間を短縮する効果が認められた
Example 1
Dissolved Staphylococcus aureus enzyme 0.001 g dissolved bacteria enzyme 3 g chitosan 10 g sodium chloride 0.9 g Water other.
Make 100ml sterilization stock solution, immerse 4cm bamboo fiber gauze of 14cm x 7cm in 5ml sterilization stock solution, and use this for dermatology, surgery, gynecology, etc. was Tsu used in the prevention or treatment of infection of the surface of bacteria and fungi. The effect of promoting healing of the wound surface and shortening the treatment time was observed .

実施例2
溶解ブドウ球菌酵素 0.1グラム
溶解菌酵素 10グラム
キトサン 5グラム
ポリエチレングリコール1000 2グラム
塩化カリウム 1グラム
水 他。
100mlの殺菌原液を作り、14cm×7cmの4枚あわせの竹繊維ガーゼを2mlの殺菌原液の中に浸し、これをベビー及び大人用紙オムツの中に使った。幼児や介護老人の細菌と真菌の感染の予防できる効果が認められた
Example 2
Dissolved staphylococcal enzyme 0.1 grams Dissolved bacterial enzyme 10 grams Chitosan 5 grams Polyethylene glycol 1000 2 grams Potassium chloride 1 gram Water, etc.
Create a sterilization stock solution of 100ml, soak the bamboo fiber gauze of 4-ply of 14cm × 7cm in the sterilization stock solution of 2ml, which was Tsu used in the baby and adult paper diapers. Effect that can prevent the infection of bacteria and fungi of infants and nursing old man was found.

実施例3
溶解ブドウ球菌酵素 0.01グラム
溶解菌酵素 8グラム
ポリエチレングリコール1000 6グラム
リン酸カリウム 0.7グラム
水 他
100mlの殺菌原液を作り、14cm×7cmの4枚あわせの竹繊維ガーゼを4mlの殺菌原液の中に浸し、これを女性用ナプキンの中に使った。膣感染の予防ができる効果が認められた
Example 3
Dissolved staphylococcal enzyme 0.01 gram Dissolved bacterium enzyme 8 gram Polyethylene glycol 1000 6 gram Potassium phosphate 0.7 gram Water, etc. Make 100 ml of sterilized stock solution, and 4 ml of 14 cm x 7 cm bamboo fiber gauze together with 4 ml of sterilized stock solution dip them in, which was Tsu used in a feminine napkin. The effect which can prevent vaginal infection was recognized .

綿繊維の顕微鏡写真である。 It is a microscope picture of cotton fiber . 竹繊維の顕微鏡写真である。 It is a microscope picture of bamboo fiber .

Claims (6)

殺菌原液の組成分及びその重量パーセンテージが、
溶解ブドウ球菌酵素 0.001−1%
溶解菌酵素 0.1−20%
タンパク質安定剤 0.2−50%
イオン化合物 0.5−10%
水 他
からなり、
前記タンパク質安定剤は、キトサン、ポリエチレングリコール400、ポリエチレングリコール1000、ポリエチレングリコール4000或いはポリエチレングリコール6000の中の一種或いは二種以上であり、
前記イオン化合物は塩化ナトリウム、塩化カリウム、リン酸カリウム或いはリン酸ナトリウムの中の一種或いは二種以上であり、
竹繊維ガーゼが前記殺菌原液を含有していることを特徴とする殺菌竹繊維ガーゼ。
The composition of the sterilization stock solution and its weight percentage are
Dissolved staphylococcal enzyme 0.001-1%
Lysis enzyme 0.1-20%
Protein stabilizer 0.2-50%
Ionic compounds 0.5-10%
Water and others
Consists of
The protein stabilizer is one or more of chitosan, polyethylene glycol 400, polyethylene glycol 1000, polyethylene glycol 4000 or polyethylene glycol 6000,
The ionic compound is one or more of sodium chloride, potassium chloride, potassium phosphate or sodium phosphate,
Bactericidal bamboo fiber gauze characterized in that the bamboo fiber gauze contains the sterilizing stock solution.
前記殺菌原液の組成分及び重量パーセンテージが、
溶解ブドウ球菌酵素 0.01−0.1%
溶解菌酵素 2−10%
タンパク質安定剤 5−40%
イオン化合物 0.5−1%
水 他
からなり、竹繊維ガーゼが前記殺菌原液を含有をしていることを特徴とする請求項1に記載の殺菌竹繊維ガーゼ。
The composition fraction and weight percentage of the sterilizing stock solution,
Dissolved staphylococcal enzyme 0.01-0.1%
Lysis enzyme 2-10%
Protein stabilizer 5-40%
Ionic compounds 0.5-1%
Water and others
The sterilized bamboo fiber gauze according to claim 1, characterized in that the bamboo fiber gauze contains the sterilized stock solution.
前記殺菌原液を4枚あわせの竹繊維ガーゼ100cm 当たり1−10ml含有していることを特徴とする請求項1または2に記載の殺菌竹繊維ガーゼ。 The sterilized bamboo fiber gauze according to claim 1 or 2, wherein the sterilized undiluted solution contains 1-10 ml per 100 cm 2 of bamboo fiber gauze of 4 sheets . 前記殺菌原液を4枚あわせの竹繊維ガーゼ100cm 当たり4−6ml含有していることを特徴とする請求項3に記載の殺菌竹繊維ガーゼ。 4. The sterilized bamboo fiber gauze according to claim 3, wherein the sterilized undiluted solution contains 4-6 ml per 100 cm < 2 > of bamboo fiber gauze. 創傷面傷当て材として用いられることを特徴とする請求項1〜4の何れか1項に記載の殺菌竹繊維ガーゼ。 The sterilized bamboo fiber gauze according to any one of claims 1 to 4, which is used as a wound surface scratching material . 前記殺菌竹繊維ガーゼは織物、編物または不織布からなり、ベビー用或いは大人用紙オムツ、ナプキン或いはマスクとして用いられることを特徴とする請求項1〜4の何れか1項に記載の殺菌竹繊維ガーゼ。 The sterilized bamboo fiber gauze according to any one of claims 1 to 4, wherein the sterilized bamboo fiber gauze is made of a woven fabric, a knitted fabric, or a non-woven fabric, and is used as a baby or adult paper diaper, napkin, or mask .
JP2004249338A 2004-08-03 2004-08-03 Sterilized bamboo fiber gauze Expired - Lifetime JP4679854B2 (en)

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CN1360949A (en) * 2000-12-28 2002-07-31 上海高科生物工程有限公司 Bactericidal gauze with lysostaphin complex enzyme
JP2003310721A (en) * 2002-04-25 2003-11-05 Miyo Kk Antibacterial cloth made of bamboo fibers
CN1461827A (en) * 2002-05-31 2003-12-17 余钢纲 Natural antibacterial material and its use

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1360949A (en) * 2000-12-28 2002-07-31 上海高科生物工程有限公司 Bactericidal gauze with lysostaphin complex enzyme
JP2003310721A (en) * 2002-04-25 2003-11-05 Miyo Kk Antibacterial cloth made of bamboo fibers
CN1461827A (en) * 2002-05-31 2003-12-17 余钢纲 Natural antibacterial material and its use

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