CN101324029A - Antibiotic and hydrophilic nonwoven, preparation and use thereof - Google Patents

Abstract

The invention discloses an antisepsis and hydrophilous non-woven fabric that is coated and covered with fibroin and chitin; the invention further discloses a preparation method of the non-woven fabric, which comprises following steps: the non-woven fabric is doubly dipped and doubly rolled in a finishing solution that contains the fibroin and the chitin at the temperature of 20 to 40 DEG C, and then baked and fixed at the temperature less than 160 DEG C. By coating and covering the fibroin and the chitin onto the surface of the non-woven fabric, the non-woven fabric of the invention is provided with hydrophilous, bacteriostasis and sterilization effects without obvious influence to the appearance. The produced non-woven fabric can be used for disposable medical and health materials.

Description

A kind of have antibiotic and hydrophilic non-weaving cloth and its production and application

Technical field

The invention belongs to the functional material field, particularly a kind of have antibiotic and hydrophilic non-weaving cloth and its production and application.

Background technology

Some medical and health use non-weaving cloths as terylene, polypropylene fibre, cause the hydrophilicity of product poor because aspects such as processing characteristic and product cost adopt synthetic fiber for a long time mostly; Simultaneously, this class material has very high antibiotic requirement to it from be worked into use.Therefore, it is imperative that exploitation has hydrophilic and medical and health use non-weaving cloth anti-microbial property.

Improving the hydrophilic and anti-microbial property of non-weaving cloth and fiber can be undertaken by method physics, chemistry, as precursor modification, surface graft modification, functional treatment (as padding method or infusion process) etc.Wherein, the functional treatment method is easy, with low cost, can increase its hygroscopicity and antibiotic property on the basis of basic maintenance non-weaving cloth primary characteristic, thereby become the comparatively general a kind of method of application.But there is the problem of poor durability in functional treatment.

The medical and health use non-weaving cloth comprises pasteurization towelette, wound dressing, hemostasis subsides, bandage, gauze ball, ointment cloth, imbibition pad etc., and with promptly abandoning material, as baby diaper, sanltary towel, adult incontinent pads etc.Wherein, not high with promptly abandoning non-weaving cloth to life requirement.

Silk is that the matured silkworm time secretion silk liquid of cocooing solidifies and forms, and it is made up of two kinds of protein: i.e. the fibroin of core and surround its silk gum on every side.When being applied to the dress material material,, in concise process, remove most of silk gum in the past, mainly utilize fibroin in order to produce the unique gloss and the feel of silk; Stably isolate silk gum from scouring waste, and refining to it, this technology is ripe and reach industrialization at present.The fibroin fiber good permeability, hygroscopicity is splendid, contains 18 seed amino acids that human body had nutritive value, is applied in the clinical treatment, can be made into artificial blood vessel; Application in the non-weaving cloth field has medical dressing, is used for the burn wound clad can, helps wound healing, is also referred to as " artificial skin ".The main component of silk gum is a serine, also has asparatate, the acid of paddy oxygen, alanine, glycine in addition.Serine is the composition of natural moisturizing factor in the skin, and skin is had good affinity interaction, has to suppress the effect that wrinkle of skin generates; The medical worker of dept. of dermatology of Japan handles the brassiere test with highly purified sericin, proves that sericin has good curative effect to characteristic dermatitis.

Shitosan claims chitan, poly glucosamine, soluble chitin again, is to transform the large biological molecule that becomes through deacetylated reaction by chitin.And chitin has another name called chitin, chitin, crab shell chitosan, chitin etc., is a kind of linear glycosaminoglycan of keeping and protecting crustacean and microorganism body, extensively is present in the wing or shell of the sufficient animal class of joint (Araneae, shell-fish).Shitosan and derivative thereof have excellent broad spectrum antibacterial, shitosan has good hygroscopicity, biocompatibility and biological degradability simultaneously, and catabolite generally has no side effect to human body, does not put aside in vivo, non-immunogenicity, thereby utmost point wide prospect is arranged at biomedical sector.Developed with potential application example and comprised artificial skin (wound dressing), operation suture thread and bone renovating material, anticoagulant and hemodialysis's film, pharmaceutical preparation and drug agent etc.

Summary of the invention

The objective of the invention is to overcome deficiency of the prior art, a kind of antibiotic and hydrophilic non-weaving cloth that has is provided, be coated with fibroin and chitin on the described non-weaving cloth.

Described fibroin is fibroin albumen or sericin.

Described chitin is the chitin of deacetylation＞90%.

Described non-weaving cloth is polypropylene spunbond non-weaving cloth, terylene hydro-entangled non-woven fabric, terylene spun-bonded non-weaving cloth or viscose glue/terylene hydro-entangled non-woven fabric.

The present invention also provides a kind of method for preparing aforesaid non-weaving cloth, may further comprise the steps: under 20 ℃～40 ℃ temperature, with non-weaving cloth in the dressing liquid that contains fibroin and chitin two soak two roll after, under＜160 ℃ condition, bake set.

Described dressing liquid also contains formaldehyde binder, and its each component reaches and is by weight percentage:

Fibroin 0.5～5%

Chitin 0.5～5%

Formaldehyde binder 5～20%

Its surplus is a water.

Described chitin is to be dissolved in＜chitin in 1% the aqueous acetic acid.

Non-weaving cloth of the present invention is used for promptly abandoning medical and health.

The present invention has following beneficial effect: non-weaving cloth of the present invention by fibroin and chitin being coated to the surface of non-weaving cloth, makes non-weaving cloth have hydrophilic, restraining and sterilizing bacteria effect, and the non-weaving cloth outward appearance is not had obvious influence.The non-weaving cloth that makes can be used for promptly abandoning medical and health.

The specific embodiment

Below in conjunction with embodiment technical scheme of the present invention is described:

A kind of antibiotic and hydrophilic non-weaving cloth that has of the present invention is coated with fibroin and chitin on the non-weaving cloth.Fibroin is fibroin albumen or sericin.Chitin is the chitin of deacetylation＞90%.

Embodiment 1,

The pad groove of polypropylene spunbond non-weaving cloth by dressing liquid carried out two and soak two and roll, and the content of chitin and fibroin albumen is 1% in the dressing liquid, and the WH adhesive is 5%; bath raio is 1: 50, and temperature is 25 ℃, pick-up 100%; preliminary drying (70 ℃) then, bakes (130 ℃).This non-weaving cloth can effectively kill 83.4% Escherichia coli E.coli and 80.6% Staphylococcus aureus S.aureus, and hydrophily has increased by 4.6 times.

The antibiotic property method of testing:

Cut-off directly is non-weaving cloth and the untrimmed non-weaving cloth behind 1 centimetre the functional treatment, ultraviolet irradiation sterilization (irradiation time is 30 minutes), and sterilized water soaks into; Sample is put respectively to aseptic Tissue Culture Dish, respectively added 50 microlitre inoculums (10 subsequently ⁶The CFU/ milliliter), and in 37 ℃ of insulating boxs cultivated 2 hours; In culture dish, respectively add 1 milliliter of phosphate buffer, and clean (64kHz with ultrasonic wave, 2 minutes), respectively get 50 microlitre gradient dilutions then, the different dilution bacterium buffer solutions of 50 microlitres are added in the culture dish, with spreading rod bacterium liquid is uniformly coated on the solid agar medium, and places 37 ℃ of insulating boxs to cultivate 24 hours; Come the antibacterial ability of calculation sample according to the number of bacterium colony on the solid agar medium.

The hydrophily method of testing:

According to " People's Republic of China's professional standard textiles capillary effect test method (FZ/T01071-1999) ", non-weaving cloth and the untrimmed non-weaving cloth sample of clip behind functional treatment, long 30cm, wide 3cm.Is after 20 ± 2 ℃, relative humidity are to place 24h under 65% ± 3% the standard atmosphere condition with sample in temperature, vertically be placed in the fabric capillary effect instrument, 27 ℃ ± 2 ℃ of water temperatures, sample entry length 30mm, measure the sepage height of every sample bar behind the 30min at once, calculating hydrophily increases degree.Test is that 20 ± 2 ℃, relative humidity are to carry out under 65% ± 3% the standard atmosphere condition in temperature.

Embodiment 2:

The pad groove of terylene hydro-entangled non-woven fabric by dressing liquid carried out two and soak two and roll, and chitin content is 2% in the dressing liquid, and sericin content is 5%, the WH adhesive is 10%, and bath raio is 1: 50, and temperature is 20 ℃, pick-up 100%, preliminary drying (70 ℃) bakes (125 ℃) then.This non-weaving cloth can effectively kill 85.7% Escherichia coli E.coli and 82.3% Staphylococcus aureus S.aureus, and hydrophily has increased by 6.9 times.

Embodiment 3:

The pad groove of 70/30 viscose glue/terylene hydro-entangled non-woven fabric by dressing liquid carried out two and soak two and roll, chitin content is 5% in the dressing liquid, fibroin albumen content is 3%, the WH adhesive is 10%; bath raio is 1: 50, and temperature is 40 ℃, pick-up 100%; preliminary drying (70 ℃) then, bakes (155 ℃).This non-weaving cloth can effectively kill 88.1% Escherichia coli E.coli and 86.3% Staphylococcus aureus S.aureus, and hydrophily has increased by 4.2 times.

Embodiment 4:

The pad groove of terylene spun-bonded non-weaving cloth by dressing liquid carried out two and soak two and roll, and chitin content is 5% in the dressing liquid, and sericin content is 5%, the WH adhesive is 20%, and bath raio is 1: 50, and temperature is 30 ℃, pick-up 100%, preliminary drying (70 ℃) bakes (140 ℃) then.This non-weaving cloth can effectively kill 87.2% Escherichia coli E.coli and 86.5% Staphylococcus aureus S.aureus, and hydrophily has increased by 7.6 times.

At last, it is also to be noted that what more than enumerate only is specific embodiments of the invention.Obviously, the invention is not restricted to above examples of implementation, many distortion can also be arranged.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.

Claims (8)

1, a kind of have an antibiotic and hydrophilic non-weaving cloth, it is characterized in that: be coated with fibroin and chitin on the described non-weaving cloth.

2, non-weaving cloth according to claim 1 is characterized in that: described fibroin is fibroin albumen or sericin.

3, non-weaving cloth according to claim 1 is characterized in that: described chitin is the chitin of deacetylation＞90%.

4, non-weaving cloth according to claim 1 is characterized in that: described non-weaving cloth is polypropylene spunbond non-weaving cloth, terylene hydro-entangled non-woven fabric, terylene spun-bonded non-weaving cloth or viscose glue/terylene hydro-entangled non-woven fabric.

5, a kind of method for preparing the described non-weaving cloth of claim 1, it is characterized in that may further comprise the steps: under 20 ℃～40 ℃ temperature, with non-weaving cloth in the dressing liquid that contains fibroin and chitin two soak two roll after, under＜160 ℃ condition, bake set.

6, the preparation method of non-weaving cloth according to claim 5 is characterized in that: described dressing liquid also contains formaldehyde binder, and its each component reaches and is by weight percentage:

Fibroin 0.5～5%

Chitin 0.5～5%

Formaldehyde binder 5～20%

Its surplus is a water.

7, according to the preparation method of claim 5 or 6 described non-weaving cloths, it is characterized in that: described chitin is to be dissolved in＜chitin in 1% the aqueous acetic acid.

8, the described non-weaving cloth of claim 1 is used for promptly abandoning medical and health.