US3728213A - Antibiotic paper - Google Patents

Antibiotic paper Download PDF

Info

Publication number
US3728213A
US3728213A US00172880A US3728213DA US3728213A US 3728213 A US3728213 A US 3728213A US 00172880 A US00172880 A US 00172880A US 3728213D A US3728213D A US 3728213DA US 3728213 A US3728213 A US 3728213A
Authority
US
United States
Prior art keywords
fibers
paper
percent
web
pseudourea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00172880A
Inventor
C Hinz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
Wyeth Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings LLC filed Critical Wyeth Holdings LLC
Priority to US17288071A priority Critical
Application granted granted Critical
Publication of US3728213A publication Critical patent/US3728213A/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • DTEXTILES; PAPER
    • D21PAPER-MAKING; PRODUCTION OF CELLULOSE
    • D21HPULP COMPOSITIONS; PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D; IMPREGNATING OR COATING OF PAPER; TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G; PAPER NOT OTHERWISE PROVIDED FOR
    • D21H21/00Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties
    • D21H21/14Non-fibrous material added to the pulp, characterised by its function, form or properties; Paper-impregnating or coating material, characterised by its function, form or properties characterised by function or properties in or on the paper
    • D21H21/36Biocidal agents, e.g. fungicidal, bactericidal, insecticidal agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/46Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria

Abstract

Cellulose fibers possess strong antibiotic properties (including antiviral properties) when they have a uniform content of a small amount of a 2-(C8-C18 substantially straight chain) pseudourea. The fibers remain antimicrobial when in addition they contain a normally water-soluble thermosetting wet strength resin in thermoset state. Antibiotic bandages, diapers, bed sheets, boxes, surgeons'' gowns, etc. can be prepared from paper composed of these fibers.

Description

United States Patent 1191 Hinz 1 221 Filed:

[ ANTIBIOTIC PAPER [75] Inventor: Charles Frank Hinz, East Norwalk,

Conn.

[73'] Assignee: American Cyanamid Company, Stamford, Conn.

Aug. 18, 1971 [21] Appl. No.: 172,880

Related US. Application Data [63] Continuation-impart of Ser. No. 773,954, Nov. 6, I968, abandoned, and a continuation-in-part of Ser. No. 42,479, June 1, 1970, abandoned.

[52] U.S.-Cl. ..162/l6l, 47/9, 162/158, i 424/28, 424/322 [51] Int. Cl. ..D2lh 5/22, D21h 3/12 [58] Field of Search ..162/158, 161,190; 424/322, 326, 2729 [56] References Cited UNITED STATES PATENTS 2,923,656 2/l960 Hackman ..424/322X 2,980,734 4/1961 Kosmin ..424/322 x 3,060,079 l0/l962 PamnOCh 162/161 3,483,296 12/1969 Martin ..l62/l61 x FOREIGN PATENTS OR APPLICATIONS 618,089 4/1961 Canada 162/161 Primary Examiner-S. Leon Bashore Assistant Examiner'-Wi11iam F. Smith Attorney-Evans Kahn 5 7] ABSTRACT 7 Claims, No Drawings ANTIBIOTIC PAPER This is a continuation-in-part of my copending applications, Serial Nos. 773,954 and 42,749, respectively, filed November 6, 1968 and June 1, 1970, and now both abandoned.

The present invention relates to cellulose fibers and fibrous cellulose structures having antimicrobial properties. More particularly, the invention relates to cellulose fibers, water-laid cellulose webs (including paper) and articles made therefrom having antimicrobial properties resulting from the presence therein of a uniformly adsorbed content of an ionic pseudourea, and to methods for the manufacture of said fibers and webs. For convenience, the term antimicrobial is hereafter used to describe the inhibiting of the life of all microbes including fungi, bacteria, protozoa and viruses.

Antimicrobial paper is paper composed of fibers which have an effective content of an agent which inhibits the growth thereon of some or all of the forms of life just mentioned. In the past, the principal use of such paper has been as mulch paper (paper which is spread on the ground to inhibit the growth of weeds and the evaporation of water), but such paper is coming to find important use for such purposes as handages, boxes for bandages and other surgical equipment, diapers, surgical drape sheets, hospital gowns and bed sheets, and as the base for surgical adhesive tape. Such items are commonly supplied in sterile form, and during their period of use they must resist microbial growth. Paper which possesses antiviral properties is urgently desired, for example in connection with the care of patients with head colds, influenza and mumps.

Because of the long period of time during which it must maintain its integrity in the warmth and humidity of the environment, mulch paper must be highly and comparatively permanently resistant tomicrobial attack. Mulch paper is moist during much of its life at a temperature most favorable to the growth of microorganisms, andis subject to severe tearing forces (e.g., by

t the wind) from time to time. Mulch paperdesirably maintains its identity and strength during the growing season and nevertheless should ultimately succumb to attack by microorganisms, i.e., it should be greatly weakened or disintegrated by them within two to three months after being plowed under ground at the end of the growing season. PaPer used for bandages, hospital outdoor weathering. l have found that in preferred embodiments such as when the paper is sufficiently antimicrobial to strongly resist the growth of microbial life under incubating conditions, the fibers carrying a pseudourea of the type described remain substantially sterile.

The present invention in preferred embodiments provides improvements as follows:

respect to yeasts, bacteria, protozoa, and lipophilic viruses. 2. Paper comprising the aforesaid fibers possesses similar antimicrobial properties and remains substantially sterile when employed as diaper material for babies, surgical drape sheets, hospital gowns bed sheets, etc.

3. The paper strongly resists attack by microorganisms found in agricultural fields, and this activity is not masked when the paper has an effective amount of a normally water-soluble wet strength resin in thermoset state. Moreover, the paper is readily permeable by water, and hence permits rain to penetrate into the ground, and is accordingly well-suited for use as mulch paper. The paper is substantially unaffected by the action of microorganisms when allowed to remain for three to five months on fields under temperature and humidity conditions highly conducive to the rapid growth of microorganisms (temperatures of F. F. and relative humidity in excess of 50 percent).

The microbial life against which the paper of the present invention possesses activity include the bacteria, (including sulfate-reducing bacteria), yeasts, fungi, and green algae, and lipophilio viruses.

The pseduoureas referred to have the formula alkyl substituents include octyl, dodecyl, hexadecyl and 1 octadecyl. The aforesaid pseudoureas dissolve in water containing a stoichiometric excess of hydrochloric acid,'acetic acid, formic acid, trichloroacetic acid,

nitric acid, phosphoric acid or other strong acid. The molecule as awhole is cationic.

The amount of pseudourea present in cellulose fibers and in the paper of the present invention depends upon the specific antimicrobial activity of the pseudourea present, the vitality of the microorganisms present, and the degree of antimicrobial activity which it is desired that the fibers (or paper, paperboard, etc. which have a content thereof) should possess. As a rule of thumb, I have foundthat in most instances, cellulose fibers possess perceptible antimicrobial activity when they contain as little as 0.1 percent of the pseudourea based on the dry weight of the fibers. On the other hand, I have found that the fibers need not contain more than about 3 percent by weight of the pseudourea for them to possess very satisfactory antimicrobial activity. .My results to date indicate that satisfactory results are obtained when the fibers contain between about 0.3 percent and 0.5 percent by weight of the pseudourea as in this range the fibers (and the paper) possess very satisfactory antimicrobial activity yet over-use of the pseudourea. is avoided. The optimum amount of pseudourea that need be present in any instance to procure the desired antimicrobial activity can be readily found by laboratory trial.

The pseudoureas referred to above are most conveniently applied by forming an aqueous suspension of cellulose fibers and adding to the suspension one or more of the aforesaid pseudoureas as a water-soluble salt. The pseudourea component of the salts are rapidly and substantively absorbed by the fibers and the amount of pseudourea which is present in the fibers of the final product can be determined by calculation based on Kjeldahl nitrogen analysis.

Thereafter the suspension is processed into paper or paperboard in any customary manner. The fibers are formed into a web web by flowing the suspension over a foraminous substrate, and the web is dried at an elevated temperature into the desired form.

For the manufacture of cotton wool the fibers in the suspension may be allowed to accumulate on the foraminous substrate so as to form a wet web of substantial thickness which may be dried, and the resulting batt carded so as to separate the fibers into a fluffy wool-like product.

For processing into paper, the suspension is formed into a wet web at some normal basis weight and the wet web is dried over steam-heated rolls.

In many instances when the end product is paper or paperboard, it is desired that such product possess wet strength properties. These properties can be imparted by adding any of the known cationic thermosetting wet strength resins for paper along with the pseudourea, or by applying the wet strength resin subsequently, for exampleat the size press, the paper being subsequently the present invention possess superior dry strength without possessing permanent wet strength (to facilitate disposal of the paper after use). This can be accomplished by adding a water-soluble cationic or non-ionic dry strengthening agent along with pseudourea. Suitable polymers for this purpose are disclosed in Woodberry, U.S. Pat. Nos. 2,959,514 and 3,258,393.

The invention will be further illustrated by the following examples which illustrate embodiments of the invention and are not to be construed as limitations thereon.

EXAMPLE 1 The following illustrates the manufacture of antimicrobial cellulose fibers resulting from the presence thereon of a small amount of water-insoluble pseudourea.

Aliquots are taken from an aqueous neutral suspension of well-beaten cellulose papermaking fibers at a consistency 0.6 percent and to these are respectively added sufficient of 10 percent by weight solutions of:

l n-Decylpseudourea hydrochloride 2. n-Dodecylpseudourea nitrate .3. n-Dodecyl-N,N-dimethylpseudourea acetate 4. n-Hexadecylpseudourea trichloroacetate to provide up to 0.5 'percent of the urea derivative (as the free base), based on the dry weight of the fibers. The pH of the aliquots is then adjusted to 6, and the suspensions are gently stirred for a minute to permit the pseudourea to be adsorbed by the fibers. The pH of the suspension simultaneously decreases.

The resulting suspensions are formed into thick water-laid webs on a laboratory handsheet machine which are oven-dried at 190 F and the resulting webs are hand-carded using a textile carder. Fluffy resilient masses are obtained which resemble surgical cotton wool. I

Samples of the cotton wool are respectively sprayed with suspensions of: g

. Aerobacter aerogenes Bacillus cereals var. mycoides Pseudamonas aefuginosa Chaetamium globosum i Penicillium citrinum Penicillium expdnsum Trichoderma viride Aspergillusflavus Fusarium moniliforme l0. Aspergillus niger in a standard laboratory nutrient medium (agar-agar medium containing protein as source of nitrogen, carbohydrate, and calcium, magnesium, potassium and iron salts of the type normally present in said medium) to provide nutritional requirements for the microbial life thereon. The samples are allowed to stand for three days at 30 C. and 75 percent relative humidity, to permit the fibers to exert their biocidal properties, and then are incubated on sterile agar plates, in comparison with control samples of cotton wool which contain no antimicrobial agent, to determine the extent to which the microbial life has been arrested. At the end of the incubation period the plates carrying the test cotton wool are substantially or completely free from microorganisms, whereas the control plates carry heavy growths of microorganisms.

seepage-m EXAMPLE 2 The following illustrates the manufacture and use of mulch paper according to the present invention.

Into a furnish composed of a50z50 mixture of hard wood and soft wood papermaking fibers at pH 4.5 at a consistency of 0.6 percent, as it passes through the machine chest in a paper mill, is metered a 5 percent by weight solution of n-dodecylpseudourea hydrochloride at a sufficient rate to provide 0.5 1 percent of ndodecylpseudourea (as the free base) based on the dry .weight of the fibers and a solution of the melamine-formaldehyde wet strength acid colloid of Maxwell et al. U.S. Pat. No. 2,345,543 at the same rate. The furnish is processed into paper at a basis weight of 50 lbs. per 25" X 40"/500 ream, and the paper is dried at 190 F.-250 F. for about 1 minute. Kjeldahl nitrogen analyses of the paper show that the dry paper contains 60 percent percent by weight of the dodecylpseudourea which had been added. From experience it is known that most of the remainder was adsorbed by the cellulose fibers, which were lost with the white water.

The resulting paper is transported to a pineapple plantation, and is rolled upon the ground by an automatic pineapple seedling planter. Pineapple seedlings are then planted through approximately 1 inch diameter holes punched through the paper.

The paper largely prevents the growth of weeds around the seedlings, does not support microbiological growth during the period that the pineapples are growing, resists tearing when wet, and shortens the vegetation period of the pineapples. The paper loses virtually all its strength and disintegrates to fibrous state within three months after being ploughed under the ground.

EXAMPLE 3 The procedure of Example 2 is repeated except that the paper is applied as a mulch for watermelons, cauliflower, cabbage, celery, parsnips and tomatoes grown in a Florida soil. Similar results are obtained.

EXAMPLE 4 The following illustrates the remarkable antimicrobial properties possessed by a preferred paper of the present invention.

A sample of the paper of Example 2 is pressed upon a sterile Petri dish of agar upon which has previously rhesus monkey kidney cultures. A control is prepared consisting of 0.5 ml. of the virus in. 4.5 ml. of Earls lactalbumin hydrolysate medium.

The virucidal effectiveness of the solution is determined by the hemadsorption test wherein 3 days after inoculation the cell culture tubes are washed twice with 1.0 ml. of phosphate-buffered saline solution and 1 ml. of 0.4 percent guinea pig erythrocytes is added to each tube. The tubes are incubated for 20 minutes at 4" C. and washed again with 1.0 ml. of the saline solution. The erythrocytes adsorbed the monkey kidney cells that are infected with influenza.

The procedure is repeated except that 2-n-dodecyl- N,N-dimethyl pseudourea dihydro'gen phosphate is used in place of the acetate.

The virus potency (log TCID /ml.) is 5.2 for the control and 2.2 for each of the tests with the pseudou rea salts, where TCID represents Tissue Culture lnfection Dose.

Each of the pseudourea salts is toxic to the virus concentrations at 10'.

Control 1 Percent virus Test number Virus nsvd DPA P DDPITP 3 Test method used DPA 1 DDPHP 3 A Influenza ll 5.2 22 22 llemadsorption 100 100 13.. Adeuovirus type 3. 5. t 4. 7 4. 7 Viral eytopathologv... 80 80 C. Parainfluenza 3 4.2 22 22 d0 5 99.2 99, 2 1). Influenza A l5. 0 2. 2 2. 2 Hornadsorption 100 100 E.. Herpes simplex Vlt 2150 6.9 3. 2 3. 2 Viral cytopathology L 99. 2 99. 2 F U Para inlluenzali 5.7 2.2 llernadsorption 100 1 Log TCID/ /ml. (TCIl)=tissue culture infection (lOSl).

1 2-(n-d0decyl) pseudourea acetate.

3 2-(n-dodecyl)-l,1dimethyl-psoud0nrea dihydrogvn phosphate. 4 In this test the concentration of the dodecylpseudourea is 50 p,p.n1.

5 And hemadsorption.

been sprinkled an aqueous suspension of Aspergillus niger and other fungal spores. The dish is incubated at C. along with a control dish which contains no paper. After 48 hours the control dish carries a heavy growth of fungi, but the paper in the test dish shows no growth whatever. I

EXAMPLE 5 EXAMPLE 6 The following illustrates the virustatic and virucidal efficiency of the pseudoureas against typical lipophilic viruses.

Virus Used: Influenza B (National lnstitute of Health s Massachusetts Strain RMK-3) 80 mg. of 2-n-dodecylpseudourea acetate is dissolved in 200 ml. of warm distilled water giving a solution containing 400 ppm. of the agent. To 4.5 ml. of this solution is added 0.5 of the virus and shaken to form a uniform solution. The solution is maintained at 22C. 'for 10 minutes. Several dilutions are made to below 10 biocide concentration and inoculated into Example 7 The following illustrates the manufactureofan infants diaper according to the present invention.

To an aqueous suspension of cellulose papermaking fibers at pH 4.5 and a consistency of 0.6 percent is added sufficient of an aqueous solution of n (2- decyl)pseudourea acetate to provide 2 percent based on the dry weight of the fibers. The fibers are formed into a web on a screen and the web is allowed to air dry. The web is carded to form cotton wool whichv is formed into a batt about 18 inches X 18 inches X Vi inch. The batt is placed between two sheets of wet strength paper 18 inches l8 inches, one of. which is sized and the other is unsized. The edges of the two sheets are bound together with pressure-sensive adhesive tape.

Example 8 The following illustrates the antimicrobial effect of increasing amounts of a preferred antimicrobial agent as afunction of the kinds of microbial life present.

A water-leaf paper sheet (paper containing no additive) of 40 lb. basis weight per 25" X 40"/500 ream is immersed in a 0.05 percent by weight solution of 2-ndodecyl pseudourea (PU) and removed. Surplus solution is allowed to drain off. The resulting wet web is dried for one minute on a laboratory drum drier having a drum temperature of 240 F. and contains about 0.05 percent of the pseudourea by weight. The procedure is successively repeated with solutions of increasing strength, yielding papers of the psedudourea content shown in the table below.

The papers are then tested for their antimicrobial power against fungus (Aspergillus niger), and on a bacterium (Aerobacter aerogenes).

Results are as follows.

Growth After 48 PU Hours at 80F. No. In Paper Fungus Bacterium Control None Heavy Heavy l 0.05 Mod. Mod. 2 0.1 Do. Slight 3 0.2 Little Little 4 0.3 None None 5 0.5 Do. None 6 1.0 Do. Do.

Since 2-dodecylpseudourea is known to be a virucide, and since the above results show that this compound is adsorbed on paper in strongly biologically active form, it is expected that the paper described possesses strong antiviral properties as well.

Example 9 The following illustrates the manufacture of highly antimicrobial paper of excellent wet strength properties according to the invention.

To an aqueous suspension of unbleached softwood kraft fibers at 0.6 percent consistency and pH 6 in ordinary (non-aseptic) laboratory water is added with gentle stirring sufficient of a 5 percent by weight solution of 2-n-dodecylpseudourea hydrochloride to supply 3/4 percent of this compound based of the dry weight of the fibers. There is then added sufficient of a 1 percent solution of a water-soluble cationic thermosetting glyoxylated 95:5 molar ratio acrylamidezdiallyl dimethyl ammonium chloride copolymer to supply 1 percent of the polymer based of the dry weight of the fibers.

The suspension is then formed into handsheets at 50 lb. basis weight which are dried for one minute on a drying roll having a surface temperature of 220F.

The resulting paper carries about 0.6 percent and 0.8

percent by weight of the respective agents, and has a TAPPl wet tensile of 9 lb. per inch.

A 6" X 6" sheet of the paper is then inoculated with stock laboratory cultures so as to place on the sheet cultures of a bacterium and a fungus, and the sheet is allowed to airdry at 80F. for 30 minutes. The sheet is then rolled in a plastic sheet and allowed to incubate in the dark for 48 hours. The sheet is then incubated and is found to be sterile.

Example l0 An experimental childs diaper (a commercial cloth diaper having pinned to the center a pillow" composed of a batt of cellulose papermaking fibers between two sheets of wet strength paper, the fibers in the batt and the paper containing 1 percent of n-n-dodecylpseudourea by weight) is placed about a baby in approximately customary manner and left in position until soiled. The soiled pillow is removed and a sample incubated at F. No microbial growth develops.

I claim:

1. Cellulose fibers having a uniformly adsorbed effective content within the range of 0.01 percent -3 percent based on the dry weight of the fibers as agent inhibiting the growth of microorganisms thereon of a 2- (Cg-C1 substantially straight chain alkyl) pseudourea.

2. Fibers according to claim 1 wherein the pseudourea is 2-n-dodecylpseudourea.

3. Antimicrobial paper consisting essentially of fibers according to claim 1.

4. lnfants diapers consisting essentially of a substantially square assembly of a batt of fibers according to claim 1 and two sheets of wet strength paper, one of which is sized and the other is unsized, said batt being positioned between said sheets of paper.

5. A process for the manufacture of antimicrobial paper which comprises forming an aqueous suspension of cellulose papermaking fibers, adding thereto a small but effective amount as antimicrobial agent of a salt of a 2-(C C substantially straight chain alkyl) pseudourea, forming said fibers into a wet web, and drying said web at a temperature between about F. to form paper.

6. A process according to claim 5 for the manufacture of paper which comprises forming an aqueous suspension of cellulose papermaking fibers, adding thereto sufficient of an acid solution ofa 2-(C C substantially straight chain alkyl polypseudourea) to deposit on said fibers an effective amount thereof within the range of 0.01 percent 3 percent based on the dry weight of said fibers as antimicrobial agent, adding to said suspension 0.1 percent 3 percent of a water-soluble cationic wet strength resin, forming said fibers into a web, and drying said web at a temperature between about 190 F. and 250 F.

7. A process according to claim 6 wherein the wet strength resin is a thermosetting resin containing amine-reactive substituents.

- UNITED STATES PATENT OFFICE QEE'EEMCATE OF CORRECTION Patent No. 5 7 5 Dated April 7, 97

Inventbflsg CHARLES mum HI m It is certified that error appears in the above-identified patent and that said Letters Patent arehereby corrected as shown below:

Column 1, line 2, !-2,7 +9" should read 423%??? Column 5, line 15, "web web" should read wet web Column L line 16, "i Penicillium oitrinum should read Penioillium citrinum colum 4 line 49, 0.5 1 percent" should read 0.5 percent Column 7 line 52, f the dry weight" should read on the dry weight Columhf 8 line 51 190F. to form" shouldread 190F. and 250F. to form Signed and sealed this 18th day of December 1973.

(SEAL) Attest;

EDWARD l LFLETCI-IERJR. RENE D TEGTMEYER a A ttescing Officer Acting Commissioner of Patents FORM Po-wso (10-69) USCOMM-DC 00376-5 60 9 \LS. GOVIINIINT PIIIUING OFFICE I"! 0--36rlll

Claims (6)

  1. 2. Fibers according to claim 1 wherein the pseudourea is 2-n-dodecylpseudourea.
  2. 3. Antimicrobial paper consisting essentially of fibers according to claim 1.
  3. 4. Infants'' diapers consisting essentially of a substantially square assembly of a batt of fibers according to claim 1 and two sheets of wet strength paper, one of which is sized and the other is unsized, said batt being positioned between said sheets of paper.
  4. 5. A process for the manufacture of antimicrobial paper which comprises forming an aqueous suspension of cellulose papermaking fibers, adding thereto a small but effective amount as antimicrobial agent of a salt of a 2-(C8-C18 substantially straight chain alkyl) pseudourea, forming said fibers into a wet web, and drying said web at a temperature between about 190* F. and 250* F. to form paper.
  5. 6. A process according to claim 5 for the manufacture of paper which comprises forming an aqueous suspension of cellulose papermaking fibers, adding thereto sufficient of an acid solution of a 2-(C8-C18 substantially straight chain alkyl polypseudourea) to deposit on said fibers an effective amount thereof within the range of 0.01 percent - 3 percent based on the dry weight of said fibers as antimicrobial agent, adding to said suspension 0.1 percent - 3 percent of a water-soluble cationic wet strength resin, forming said fibers into a web, and drying said web at a temperature between about 190* F. and 250* F.
  6. 7. A process according to claim 6 wherein the wet strength resin is a thermosetting resin containing amine-reactive substituents.
US00172880A 1971-08-18 1971-08-18 Antibiotic paper Expired - Lifetime US3728213A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17288071A true 1971-08-18 1971-08-18

Publications (1)

Publication Number Publication Date
US3728213A true US3728213A (en) 1973-04-17

Family

ID=22629582

Family Applications (1)

Application Number Title Priority Date Filing Date
US00172880A Expired - Lifetime US3728213A (en) 1971-08-18 1971-08-18 Antibiotic paper

Country Status (1)

Country Link
US (1) US3728213A (en)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4615937A (en) * 1985-09-05 1986-10-07 The James River Corporation Antimicrobially active, non-woven web used in a wet wiper
US4732797A (en) * 1987-02-27 1988-03-22 James River Corporation Wet wiper natural acid preservation system
US4737405A (en) * 1985-09-30 1988-04-12 James River Corporation Binder catalyst for an antimicrobially active, non-woven web
US4740398A (en) * 1985-09-30 1988-04-26 James River Corporation Binder catalyst for an antimicrobially active, non-woven web
US4781974A (en) * 1986-04-23 1988-11-01 James River Corporation Antimicrobially active wet wiper
US4929498A (en) * 1989-01-31 1990-05-29 James River Corporation Of Virginia Engineered-pulp wet wiper fabric
US4948585A (en) * 1989-05-26 1990-08-14 Schlein Allen P Washcloth containing cleansing agent
EP0387586A1 (en) * 1989-02-27 1990-09-19 Sakai Engineering Co., Ltd. Antimicrobial/antibromic processing preparations
US5191734A (en) * 1990-04-24 1993-03-09 Kimberly-Clark Corporation Biodegradable latex web material
US5242052A (en) * 1990-06-14 1993-09-07 Highland Supply Corporation Antimicrobial material and methods
US5558873A (en) * 1994-06-21 1996-09-24 Kimberly-Clark Corporation Soft tissue containing glycerin and quaternary ammonium compounds
US5652049A (en) * 1993-11-15 1997-07-29 Paragon Trade Brands, Inc. Antibacterial composite non-woven fabric
US5666784A (en) * 1984-05-22 1997-09-16 Southpac Trust International, Inc. Floral wrapper utilizing a breathable packaging material
US5743398A (en) * 1984-05-22 1998-04-28 Southpac Trust International, Inc. Floral wrapper utilizing a breathable packaging material
US5783502A (en) * 1995-06-07 1998-07-21 Bsi Corporation Virus inactivating coatings
US6382418B1 (en) 1999-12-23 2002-05-07 Southpac Trust International, Inc. Floral wrapper utilizing a breathable packaging material
EP1291460A1 (en) * 2000-05-30 2003-03-12 Ajinomoto Co., Inc. Fiber product having antibacterial and deodorant function
US20030108761A1 (en) * 2001-09-12 2003-06-12 Tammy Eddlemon Anti-bacterial paper products
US20040038605A1 (en) * 2002-01-24 2004-02-26 Hooper Douglas L. Material and process for self-regulating temperature, wickability, flame- , biological-agent-, and soil-resistant controlled yarn, substrate or fabric
US20040083556A1 (en) * 2000-05-30 2004-05-06 Masahiko Kurauchi Fiber product having antibacterial and deodorant function
EP1576882A1 (en) 2004-03-18 2005-09-21 Biopack Ltd Pest-impervoius packaging material and pest-control composition
US20060105657A1 (en) * 2004-11-12 2006-05-18 Cline Harry B Microbial resistant kraft facing for fiberglass insulation
US7213366B1 (en) * 1998-06-29 2007-05-08 Bentle Products Ag Mixture of a carrier and additives for use in germinating units containing seeds or similar growth-suited parts of a plants as well as a method of producing the mixture
US20120301536A1 (en) * 2010-01-18 2012-11-29 Cascades Canada Ulc Anti-microbial tissue paper and process to manufacture same
US20130197461A1 (en) * 2009-05-28 2013-08-01 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9512563B2 (en) 2009-05-28 2016-12-06 Gp Cellulose Gmbh Surface treated modified cellulose from chemical kraft fiber and methods of making and using same
US9511167B2 (en) 2009-05-28 2016-12-06 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9512237B2 (en) 2009-05-28 2016-12-06 Gp Cellulose Gmbh Method for inhibiting the growth of microbes with a modified cellulose fiber
US9951470B2 (en) 2013-03-15 2018-04-24 Gp Cellulose Gmbh Low viscosity kraft fiber having an enhanced carboxyl content and methods of making and using the same
US10138598B2 (en) 2013-03-14 2018-11-27 Gp Cellulose Gmbh Method of making a highly functional, low viscosity kraft fiber using an acidic bleaching sequence and a fiber made by the process

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2923656A (en) * 1952-01-08 1960-02-02 Shell Dev Acyl thiourea fungicidal and bactericidal compositions and method of protecting plants with the same
CA618089A (en) * 1961-04-11 E.I. Du Pont De Nemours And Company Paper treatment
US2980734A (en) * 1959-03-10 1961-04-18 Monsanto Chemicals Thiopseudourea derivatives
US3060079A (en) * 1960-08-05 1962-10-23 Michigan Res Lab Inc Germicidal paper and method
US3483296A (en) * 1965-03-25 1969-12-09 Ciba Ltd Method of combatting microorganisms with benzylthioureas

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA618089A (en) * 1961-04-11 E.I. Du Pont De Nemours And Company Paper treatment
US2923656A (en) * 1952-01-08 1960-02-02 Shell Dev Acyl thiourea fungicidal and bactericidal compositions and method of protecting plants with the same
US2980734A (en) * 1959-03-10 1961-04-18 Monsanto Chemicals Thiopseudourea derivatives
US3060079A (en) * 1960-08-05 1962-10-23 Michigan Res Lab Inc Germicidal paper and method
US3483296A (en) * 1965-03-25 1969-12-09 Ciba Ltd Method of combatting microorganisms with benzylthioureas

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5921062A (en) * 1984-05-22 1999-07-13 Southpac Trust International, Inc. Method of using a floral wrapper utilizing a breathable packaging material
US5743398A (en) * 1984-05-22 1998-04-28 Southpac Trust International, Inc. Floral wrapper utilizing a breathable packaging material
US5666784A (en) * 1984-05-22 1997-09-16 Southpac Trust International, Inc. Floral wrapper utilizing a breathable packaging material
US5755320A (en) * 1984-05-22 1998-05-26 Southpac Trust International, Inc. Floral wrapper utilizing a breathable packaging material
US4615937A (en) * 1985-09-05 1986-10-07 The James River Corporation Antimicrobially active, non-woven web used in a wet wiper
US4692374A (en) * 1985-09-05 1987-09-08 James River Corporation Antimicrobially active, non-woven web used in a wet wiper
US4740398A (en) * 1985-09-30 1988-04-26 James River Corporation Binder catalyst for an antimicrobially active, non-woven web
US4737405A (en) * 1985-09-30 1988-04-12 James River Corporation Binder catalyst for an antimicrobially active, non-woven web
US4781974A (en) * 1986-04-23 1988-11-01 James River Corporation Antimicrobially active wet wiper
US4732797A (en) * 1987-02-27 1988-03-22 James River Corporation Wet wiper natural acid preservation system
US4929498A (en) * 1989-01-31 1990-05-29 James River Corporation Of Virginia Engineered-pulp wet wiper fabric
EP0387586A1 (en) * 1989-02-27 1990-09-19 Sakai Engineering Co., Ltd. Antimicrobial/antibromic processing preparations
US4948585A (en) * 1989-05-26 1990-08-14 Schlein Allen P Washcloth containing cleansing agent
US5191734A (en) * 1990-04-24 1993-03-09 Kimberly-Clark Corporation Biodegradable latex web material
US5242052A (en) * 1990-06-14 1993-09-07 Highland Supply Corporation Antimicrobial material and methods
US5652049A (en) * 1993-11-15 1997-07-29 Paragon Trade Brands, Inc. Antibacterial composite non-woven fabric
US5558873A (en) * 1994-06-21 1996-09-24 Kimberly-Clark Corporation Soft tissue containing glycerin and quaternary ammonium compounds
US5783502A (en) * 1995-06-07 1998-07-21 Bsi Corporation Virus inactivating coatings
US7213366B1 (en) * 1998-06-29 2007-05-08 Bentle Products Ag Mixture of a carrier and additives for use in germinating units containing seeds or similar growth-suited parts of a plants as well as a method of producing the mixture
US6382418B1 (en) 1999-12-23 2002-05-07 Southpac Trust International, Inc. Floral wrapper utilizing a breathable packaging material
EP1291460A1 (en) * 2000-05-30 2003-03-12 Ajinomoto Co., Inc. Fiber product having antibacterial and deodorant function
EP1291460A4 (en) * 2000-05-30 2004-03-31 Ajinomoto Kk Fiber product having antibacterial and deodorant function
US20040083556A1 (en) * 2000-05-30 2004-05-06 Masahiko Kurauchi Fiber product having antibacterial and deodorant function
US20030108761A1 (en) * 2001-09-12 2003-06-12 Tammy Eddlemon Anti-bacterial paper products
US20040038605A1 (en) * 2002-01-24 2004-02-26 Hooper Douglas L. Material and process for self-regulating temperature, wickability, flame- , biological-agent-, and soil-resistant controlled yarn, substrate or fabric
EP1576882A1 (en) 2004-03-18 2005-09-21 Biopack Ltd Pest-impervoius packaging material and pest-control composition
US7749525B2 (en) 2004-03-18 2010-07-06 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center Pest-impervious packaging material and pest-control composition
US20100236971A1 (en) * 2004-03-18 2010-09-23 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Pest-impervious packaging material and pest-control composition
US8545906B2 (en) 2004-03-18 2013-10-01 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Pest-impervious packaging material and pest-control composition
US20060105657A1 (en) * 2004-11-12 2006-05-18 Cline Harry B Microbial resistant kraft facing for fiberglass insulation
US9926666B2 (en) 2009-05-28 2018-03-27 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US20130197461A1 (en) * 2009-05-28 2013-08-01 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9970158B2 (en) 2009-05-28 2018-05-15 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9512561B2 (en) 2009-05-28 2016-12-06 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9512563B2 (en) 2009-05-28 2016-12-06 Gp Cellulose Gmbh Surface treated modified cellulose from chemical kraft fiber and methods of making and using same
US10106927B2 (en) 2009-05-28 2018-10-23 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9511167B2 (en) 2009-05-28 2016-12-06 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9512237B2 (en) 2009-05-28 2016-12-06 Gp Cellulose Gmbh Method for inhibiting the growth of microbes with a modified cellulose fiber
US9777432B2 (en) 2009-05-28 2017-10-03 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9909257B2 (en) 2009-05-28 2018-03-06 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US9512562B2 (en) * 2009-05-28 2016-12-06 Gp Cellulose Gmbh Modified cellulose from chemical kraft fiber and methods of making and using the same
US8802132B2 (en) * 2010-01-18 2014-08-12 Cascades Canada Ulc Anti-microbial tissue paper and process to manufacture same
US20120301536A1 (en) * 2010-01-18 2012-11-29 Cascades Canada Ulc Anti-microbial tissue paper and process to manufacture same
US10138598B2 (en) 2013-03-14 2018-11-27 Gp Cellulose Gmbh Method of making a highly functional, low viscosity kraft fiber using an acidic bleaching sequence and a fiber made by the process
US10294614B2 (en) 2013-03-15 2019-05-21 Gp Cellulose Gmbh Low viscosity kraft fiber having an enhanced carboxyl content and methods of making and using the same
US10174455B2 (en) 2013-03-15 2019-01-08 Gp Cellulose Gmbh Low viscosity kraft fiber having an enhanced carboxyl content and methods of making and using the same
US9951470B2 (en) 2013-03-15 2018-04-24 Gp Cellulose Gmbh Low viscosity kraft fiber having an enhanced carboxyl content and methods of making and using the same

Similar Documents

Publication Publication Date Title
GB1317156A (en) Babies napkins
JP2857756B2 (en) Method for imparting sterility or antimicrobial
US5104649A (en) Surface-functionalized biocidal polymers
EP0350275B1 (en) Preservative composition for wet wipes
JP2760814B2 (en) Disposable absorbent articles for incontinent persons
US2689809A (en) Self-sterilizing article and its preparation
US8138106B2 (en) Cellulosic fibers with odor control characteristics
US4964894A (en) Plant growth regulators derived from chitin
US7709694B2 (en) Materials with covalently-bonded, nonleachable, polymeric antimicrobial surfaces
US5707736A (en) Products having anti-microbial activity
US3092552A (en) Oligodynamic silver compositions and uses
CA1168975A (en) Germicidal absorbent body
US4655756A (en) Treated non-woven material
US3964486A (en) Disposable diaper containing ammonia inhibitor
US4367609A (en) Use of microorganisms in conjunction with seeds
KR100519551B1 (en) A microbiocidal textile, a textile material, a microbiocidal textile precursor, cotton fabric and a process for prparing them
CA1240316A (en) Copper-modified cellulose fiber
US3804094A (en) Body fluid absorbent material containing periodic acid as deodorizing agent
US3493464A (en) Fungus-resistant paper containing metallic quinolinolate formed in situ and process thereof
US5830526A (en) Light-activated antimicrobial and antiviral materials
US20100291184A1 (en) Wound dressing with apertured cover sheet
US2648165A (en) Seed carrier
US5555674A (en) Sod mats constructed of stable fibers and degradable matrix material and method for propagation
KR100863085B1 (en) Nonwovens Modified with Alkyl Polyglycoside Surfactants
US5344470A (en) Sod mats constructed of stable fibers and a degradable matrix material