JP2001302535A - Composition for medicament - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for medicament for health and for disease, in particular including extracts of Agaricus, Cordyceps sinensis and Ganoderma lucidum. SOLUTION: This composition concurrently including extracts of Agaricus, Cordyceps sinensis and Ganoderma lucidum effective and excellent in storage stability of properties, is obtained by adjusting pH of an aqueous solution/water dispersion of the composition in solution state or solid state article at pH 1.5-9.5.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical composition containing Agaricus mushroom, Cordyceps sinensis and Reishi, or an extract thereof for the purpose of maintaining health and treating diseases.

[0002]

2. Description of the Related Art Agaricus mushroom, Cordyceps sinensis and Reishi are different in their health maintenance and disease treatment effects. Therefore, they must be used together to obtain an overall effect or a synergistic effect. At present, each herbal medicine is taken as a drink, granule or tablet with each aqueous extract, but when taking each of the three existing preparations at the same time, a large amount such as 30 mL or 10 g as a whole is taken. The weight or volume must be taken at one time.

[0003]

SUMMARY OF THE INVENTION Accordingly, the present inventors
A product of a medical composition containing an extract of each of the herbal medicines of Agaricus mushroom, Cordyceps sinensis or Reishi, and having an appropriate dose or volume within 10 mL or 2 g, for example, which can comprehensively expect the effects of maintaining health and treating diseases. We studied diligently to obtain. At this time, in the solution or solid composition containing the three agents simultaneously, unlike the individual existing crude drug products, at the time of preparation,
It was also found that the appearance and taste of aqueous solutions and aqueous dispersions of solution products or solid products were easily affected by pH, and it was recognized that selection of the pH range of the composition was necessary for commercialization.

[0004]

First, as a method for preparing a solution or solid composition simultaneously containing three agents of Agaricus mushroom, Cordyceps sinensis or Reishi, an extract extract is obtained by hot water extraction, and the extract is prepared. We decided to use it as a raw material in the form of a liquid or solid product. At this time, the extracted extract solution
Each of the crude drug itself or the crushed product of the drug is extracted with hot water, and a mixture of the obtained individual extract extracts is used as a raw material, or a water extract from a simultaneous mixture of these three crude drugs is used as a raw material. . Next, the pH of the extract solution prepared as a raw material and the pH of the final product were variously adjusted, and their properties and storage stability were examined. As a result, it was confirmed that when the pH was adjusted to 1.5 to 9.5, the taste, odor and appearance were practically usable and the storage stability was high. That is, when the pH of the extract during extraction with hot water is acidic at 1.5 or less or basic at 9.5 or more, the color of the extract becomes dark during the extraction process,
There was a tendency that black precipitates were generated and an unpleasant odor such as resin odor was generated, and a similar deterioration tendency was observed with the lapse of time during storage. On the other hand, when the pH range is adjusted to 1.5 to 9.5, such alteration tendency is suppressed, and
At ~ 7.5, the suppression was more excellent, and further within the range of 3.5-5.5, the suppression was very good. Furthermore, patients who have been diagnosed with gastrointestinal cancers such as gastric cancer and colon cancer are allowed to take the medical composition of the present invention, and various symptoms associated with cancer such as general malaise, lethargy,
The effects of improving shortness of breath, anorexia, nausea, vomiting and back pain were examined by questioning of subjective symptoms. As a result, it was found that the three-drug combination example of the present invention was superior in the effect of improving various symptoms associated with cancer, as compared with the case where each crude drug as a control was used alone or in combination. The present invention has been completed based on the above findings.

[0005] As described above, the pH adjustment range of the medical composition of the present invention is 1.5 to 9.5, more preferably 2.
The range is from 5 to 6.5, more preferably from 3.5 to 5.5.

[0006] Agaricus mushroom of crude drug used in the present invention
(Scientific name: Agaricus blazei Limulus) is an edible mushroom belonging to the same genus as mushrooms, and its production area is not particularly limited and may be either artificially cultivated or natural products.

[0007] Cordyceps, a crude drug used in the present invention,
About 350 species have been found in the world, but their origin and type are not particularly limited.

[0008] The crude drug used in the present invention, Reishi (scientific name:
Mannentake) is a kind of mushroom belonging to the family Sarcophaga and its production place is not limited, and may be either artificial cultivation or natural product.

The preparation of the composition of the present invention is carried out as follows. That is, each of agaricus mushrooms, cordyceps sinensis or reishi herbal medicines or their crushed products, or a mixture of these three agents at an arbitrary ratio is immersed in hot water, and various buffers such as hydrochloric acid or sodium hydroxide and a pH stabilizer are used. To adjust the pH to 1.5 to 9.5.
And extract it by leaving it for a certain period of time. On this occasion,
When each crude drug is used alone, a mixed liquid of each extract is prepared and used as a raw material, and an extract extracted by mixing and simultaneously extracting three agents is directly used as a raw material. Next, a water-soluble polymer is added to the raw extract liquid to prepare a jelly-like composition, or the extract liquid is dried as is or by adding a bulking agent such as a saccharide and freeze-dried or spray-dried to obtain a powder. The composition is made into a state, and an excipient is added thereto to prepare a solid composition such as granules and tablets. Further, a dry or roasted pulverized powder of a medicinal or edible plant with good flavor is mixed with the above-mentioned dry powder or granules to be filled into a tea bag to obtain a composition in the form of tea.

As a more specific method of preparing the above-mentioned extract extract as a raw material, an extract extract and a dry bulk powder can be obtained, for example, under the following conditions. Each of 0.5 to 1 kg of dried agaricus, 0.5 to 1 kg of ground powder of dried Reishi, and 0.5 to 1 kg of ground powder of dried cordyceps each had a pH of 1.
3 to 6 L of hot water at 100 ° C. adjusted to the range of 5 to 9.5
The extract is immersed four times for 1 hour each, and the extracts of the four times are combined and concentrated to 1-2 L to obtain an extract extract. These three types of extracts are mixed at various ratios to obtain a raw material extract. Or a mixture of three agents 1-3 kg (dry agaricus 0.2-1.5 kg, dry reishi ground powder 0.02-0.4)
kg, dry caterpillar pulverized 0.2 ~ 0.5kg)
100 ° C. hot water 3 to 6 adjusted to the range of 1.5 to 9.5
L for 1 hour each for 4 extractions, and the combined extracts from the 4 extractions are combined and concentrated to 1 to 2 L to obtain the raw material extract. Further, 0.5 to 1 kg of soluble starch or dextrin is added to 2 L of the extract extract of the raw material, and freeze-dried or spray-dried to make a powder.

The pH adjuster at the time of extracting the extract extract of the raw material of the composition of the present invention is not particularly limited. However, citric acid, tartaric acid,
It is preferable to use various organic acids such as malic acid, and polybasic inorganic acids such as phosphoric acid and boric acid.

There are no particular restrictions on the extender added when powdering the extract extract of the raw material of the composition of the present invention and the excipient used when forming the granules or tablets, for example, starches,
Soluble starch, sucrose, fructose, maltose, reduced maltose syrup, xylitol, erythritol, mannitol, oligosaccharide, kaolin, hydrous silicon dioxide, light anhydrous silicic acid, synthetic aluminum silicate, crystalline cellulose, hardened oil, aluminum hydroxide gel, diatomaceous earth, oxidation Aluminum, magnesium carbonate, precipitated calcium carbonate, light calcium carbonate, dextrin, composite aluminum potassium silicate granules,
Examples include bentonite, ground powder of plant tissue, cyclodextrins, magnesium silicate, magnesium aluminate metasilicate, corn powder, glyceryl stearate, calcium phosphate, and the like.

In the composition of the present invention, as a method for preparing a jelly form by using a water-soluble polymer in combination with a raw extract solution, a water dilution of the extract solution is heated to a temperature of about 80 ° C. Then, a mixture of water-soluble polymer locust bean gum and carrageenan is added to make a uniform solution, which is then filled in an arbitrary packaging container and cooled.
At this time, the grade and amount of locust bean gum and carrageenan are not particularly limited.

The thickener used in the liquid composition of the present invention is not particularly limited. Examples thereof include hyaluronic acid and salts thereof, chondroitin sulfate and alkali metal salts thereof, heparin-like substances, collagen, gelatin, dextone, and methylcellulose. And neutral polymers such as hydroxypropylcellulose, hydroxypropylmethylcellulose and polyethylene glycol; and natural polymers such as sodium carboxymethylcellulose and sodium alginate.

The water used for preparing the extract extract of the raw material of the present invention is not particularly limited as long as it is sanitary, such as distilled water, tap water, groundwater, and purified water, but water having a low content of heavy metals and chlorine. It is more preferable to use

Dry tea powder of the raw material extract extract of the present invention or granules prepared using the same is mixed with a pulverized powder obtained by drying or roasting a medicinal or edible plant having good flavor and filling into a tea bag to form tea. As a plant when making the composition of,
For example, ginseng, andes ginseng, ginseng, deer mushroom, toki, blueberry, kidachi aloe, pomegranate, sesamin, stone lotus flower, garcinia, citrus, tochuha, dokudami, hama leaf, achachazul, gymnema, wolfberry, wolfberry, yamako, licorice , Lotus leaf, kumazasa, oolong, loquat leaf, barley, cinnamon, winter aoi, red bud, garland, oyster leaf, hub leaf, moloheiya, turmeric, sweet tea, ginkgo leaf, maitake, saw palmetto extract, apricot, azuki, akamegashiwa, Safflower, loquat, button, maitake, soybean, engju, butterbur, dandelion, gennoshoko, burdock, haw sow, mentha, hanamyoga, honoki, kakinoha, karin, kasiwa, mugwort, ginkgo, keihi, kihada, kikyo, kinkacha, kuchinashi, kochinashi Kunugi, Mulberry, Kudzu, Kumistin, Kang , Magnolia, peach, jujube, yam, elderberry, wild rose, pokera, psyllium, panax ginseng, rakkyo, forsythia, honey locust, cherry blossom, sanshuyu, sasa, senkyu, peonies, ginger, honeysuckle, plum, bamboo shoot, cha, oolongcha, yulongcha Touki, Udo, Fennel, Plum,
Waremokou, pokeweed, bayberry, lily, nanten,
Saxifraga, persimmon, mugwort, psyllium, twigweed, thistle, amacha, nadesico, hagi, mint, chamomile, garlic, ashitaba, amachazur, ibisgussa, taiyouto, oyster, kanzo, gimnema sylvestia, garcinia kanbobo. Murikata (barbet reed), assembly, tahibo, dokudami,
Nanana, Adlay, Hiba, Spinach, Moloheiya,
Each of the perilla is used alone or in combination of two or more.

[0017]

【The invention's effect】

Experimental example. 1. Changes in pH during preparation or storage of properties of an aqueous product containing Agaricus mushroom, Cordyceps and Reishi. (1). Sample and observation method. Agaricus extract powder 1.2kg, Reishi extract powder 0.3k
g, Cordyceps sinensis extract powder (0.4 kg) in hot water at 100 ° C.
Each was immersed 4 times in 5 L for 1 hour each, and 16 L of extract liquid was concentrated to 2 L. 20 g of this extracted sodium benzoate and 200 g of citric acid are added, and the mixture is divided into eight equal portions, and each of them is adjusted to pH 1. using 1N hydrochloric acid or sodium hydroxide.
0, 1.5, 3.0, 5.5, 7.5, 9.5, 10.
Adjusted to 0 and 10.5, filled in a colorless transparent glass bottle, sealed and stored at room temperature, pH at the time of preparation and 12 months after storage,
Observations were made on color, smell, taste, and whether or not it could be taken. (3) Observation results Tables 1 and 2 show the results. Agaricus mushroom, Cordyceps sinensis or Ganoderma herbs or a mixture of these three crude drugs, when preparing a water-extracted extract from 1.5 to 9.5, the taste, smell and Both appearances have good storage stability, and the pH of the extract when mixing the agaricus mushrooms, Cordyceps sinensis and Ganoderma herbs and extracting with hot water is 1.5 or less acidic or 9.5 or more basic. Is
During the extraction process, the color of the extract becomes dark, black precipitates are formed, and an unusual odor such as resin odor is generated. When each crude drug was extracted alone under the same conditions, such a phenomenon was not observed. However, when each extract was mixed and stored, the same tendency of deterioration was observed with the passage of time. Table 1 Table 2

Experimental example. 2. Administration test in patients diagnosed with gastric cancer (1). sample. The liquid beverage prepared in Example 1 of the present invention, one bottle at a time. (2). Administration / Observation method Take 7 doses before meals 3 times a day for 7 patients diagnosed with gastric cancer.
Monthly administration. Patients' subjective symptoms during and after administration were observed by interview. The patient was asked about various symptoms associated with cancer, such as general malaise, lethargy, shortness of breath, anorexia, nausea and vomiting, sweating and back pain. (3) Observation results Table 3 shows the number of patients who showed improvement in symptoms. The three-drug combination example of the present invention, compared with the case where the herbal medicine is used alone or in combination with two drugs, systemic malaise, lethargy, shortness of breath, anorexia,
It is excellent in improving various symptoms associated with cancer such as nausea and vomiting, sweating and back pain. Table 3

[0020]

EXAMPLES Next, the formulation and therapeutic effect of the composition for cancer treatment of the present invention will be described in detail with reference to examples.

[0021]

Example 1 Liquid drink of water extract Agaricus extract powder 1.2 kg, Reishi extract powder 0.3 k
g, Cordyceps sinensis extract powder (0.4 kg) in hot water at 100 ° C.
Each was immersed 4 times in 5 L for 1 hour each, and 16 L of extract liquid was concentrated to 2 L. 0.5 kg of soluble starch was added to this extract and spray-dried to obtain an extract powder. 1 kg of the extract powder, 20 g of sodium benzoate, 1 kg of erythritol, 0.8 kg of citric acid, 0.2 kg of oligosaccharide, and 6.98 L of purified water were mixed and dissolved at 60 ° C. for 2 hours to adjust the pH to 3.8 to 4.2. The product was adjusted, sterilized by heating three times at 90 ° C. for 30 minutes, and filled into bottles in 10 mL portions to obtain a product.

[0022]

Example 2 Granules 10 parts by mass of the spray-dried extract powder obtained in Example 1,
60 parts by weight of lactose, 28 parts by weight of corn starch and 2 parts by weight of polyvinylpyrrolidone K30 are mixed well,
% Ethanol as a granulating solvent and granulated and dried by a granulator to prepare granules having a particle size of 20 to 50 Messi.
g of each product was packaged on both sides of the metal SP package.

[0023]

Example 3 Tea 20 parts by mass of the granules obtained in Example 2, 30 parts by mass of ground pulverized powder of pearl barley, 30 parts by mass of Tonaka leaf powder and 20 parts by mass of wolfberry leaf are mixed uniformly. 10 g of this mixed powder is filled into a tea bag to make a tea product.

[0024]

Example 4 Jelly product Water liter was added to the extract solution obtained in the example, 1 part by mass of locust bean gum and 0.5 part by mass of carrageenan were added to 97 parts by mass of the extract solution, and the mixture was heated to 80 ° C. A 20 ml of each solution was filled into a polyethylene pochette container and cooled to obtain a jelly product.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61P 35/00 A61P 35/00

Claims (3)

[Claims] 1. An aqueous solution of a liquid product or a solid product which simultaneously contains an extract of Agaricus mushroom, Cordyceps and Reishi.
The medical composition wherein the pH of the aqueous dispersion is 1.5 to 9.5. 2. The medical composition according to claim 1, which is in the form of an aqueous solution or a jelly, a granule or a tablet. 3. The medical composition according to claim 1, wherein the composition is tea to which a pulverized powder obtained by drying or roasting a medicinal or edible plant is added.